Investigative Ophthalmology & Visual Science Cover Image for Volume 65, Issue 7
June 2024
Volume 65, Issue 7
Open Access
ARVO Annual Meeting Abstract  |   June 2024
Importance of baseline fluorescein angiography for uveitis patients presenting to tertiary uveitis clinic
Irmak Karaca; Albert John Bromeo; Hashem Ghoraba; Zheng Xian Thng; Amir Akhavanrezayat; Azadeh Mobasserian; Cigdem Yasar; Negin Yavari; Anh Ngoc Tram Tran; Ngoc Than; Ankur Sudhir Gupta; Anadi Khatri; S. Saeed Mohammadi; Chris Or; Diana V Do; Quan Dong Nguyen
Author Affiliations & Notes
  • Irmak Karaca
    Ophthalmology, University of Utah Health, Salt Lake City, Utah, United States
    Ophthalmology, Stanford University School of Medicine, Palo Alto, California, United States
  • Albert John Bromeo
    Ophthalmology, Stanford University School of Medicine, Palo Alto, California, United States
  • Hashem Ghoraba
    Ophthalmology, Stanford University School of Medicine, Palo Alto, California, United States
  • Zheng Xian Thng
    Ophthalmology, Stanford University School of Medicine, Palo Alto, California, United States
  • Amir Akhavanrezayat
    Ophthalmology, Stanford University School of Medicine, Palo Alto, California, United States
  • Azadeh Mobasserian
    Ophthalmology, Stanford University School of Medicine, Palo Alto, California, United States
  • Cigdem Yasar
    Ophthalmology, Stanford University School of Medicine, Palo Alto, California, United States
  • Negin Yavari
    Ophthalmology, Stanford University School of Medicine, Palo Alto, California, United States
  • Anh Ngoc Tram Tran
    Ophthalmology, Stanford University School of Medicine, Palo Alto, California, United States
  • Ngoc Than
    Ophthalmology, Stanford University School of Medicine, Palo Alto, California, United States
  • Ankur Sudhir Gupta
    Ophthalmology, Stanford University School of Medicine, Palo Alto, California, United States
  • Anadi Khatri
    Ophthalmology, Stanford University School of Medicine, Palo Alto, California, United States
  • S. Saeed Mohammadi
    Ophthalmology, Stanford University School of Medicine, Palo Alto, California, United States
  • Chris Or
    Ophthalmology, Stanford University School of Medicine, Palo Alto, California, United States
  • Diana V Do
    Ophthalmology, Stanford University School of Medicine, Palo Alto, California, United States
  • Quan Dong Nguyen
    Ophthalmology, Stanford University School of Medicine, Palo Alto, California, United States
  • Footnotes
    Commercial Relationships   Irmak Karaca None; Albert John Bromeo None; Hashem Ghoraba None; Zheng Thng None; Amir Akhavanrezayat None; Azadeh Mobasserian None; Cigdem Yasar None; Negin Yavari None; Anh Tran None; Ngoc Than None; Ankur Gupta None; Anadi Khatri None; S. Saeed Mohammadi None; Chris Or None; Diana Do Alimera Sciences, Code C (Consultant/Contractor), Apellis Pharmaceuticals, Code C (Consultant/Contractor), Belite Bio, Code C (Consultant/Contractor), Boehringer-Ingelheim, Code C (Consultant/Contractor), Genentech, Code C (Consultant/Contractor), Iveric Bio, Code C (Consultant/Contractor), Kodiak Sciences, Code C (Consultant/Contractor), Regeneron, Code C (Consultant/Contractor); Quan Nguyen Regeneron, Code C (Consultant/Contractor), Genentech, Code C (Consultant/Contractor), Boehringer-Ingelheim, Code C (Consultant/Contractor), Resolute, Code C (Consultant/Contractor), Acelyrin, Code F (Financial Support), Priovant, Code F (Financial Support), Belite Bio, Code F (Financial Support), Oculis, Code F (Financial Support)
  • Footnotes
    Support  None
Investigative Ophthalmology & Visual Science June 2024, Vol.65, 6652. doi:
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      Irmak Karaca, Albert John Bromeo, Hashem Ghoraba, Zheng Xian Thng, Amir Akhavanrezayat, Azadeh Mobasserian, Cigdem Yasar, Negin Yavari, Anh Ngoc Tram Tran, Ngoc Than, Ankur Sudhir Gupta, Anadi Khatri, S. Saeed Mohammadi, Chris Or, Diana V Do, Quan Dong Nguyen; Importance of baseline fluorescein angiography for uveitis patients presenting to tertiary uveitis clinic. Invest. Ophthalmol. Vis. Sci. 2024;65(7):6652.

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      © ARVO (1962-2015); The Authors (2016-present)

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Abstract

Purpose : This retrospective observational study aims to ascertain the role of ultra-wide-field fluorescein angiography (UWFFA) at initial (baseline) visit of uveitis patients.

Methods : Baseline visits of 158 patients who presented to Uveitis Clinic at Byers Eye Institute at Stanford between 2017 and 2022 were evaluated by 3 masked uveitis-trained ophthalmologists. Investigators were asked to successively determine disease activity, localization (anterior, posterior or anterior + posterior), and management decisions based on clinical examination, ultra-wide-field fundus photography (UWFFP) and SD-OCT (Set 1), and then Set 1 plus UWFFA (Set 2). The primary outcome was the percentage of eyes whose management changed based on the availability of UWFFA, compared with Set 1.

Results : A total of 248 eyes of 158 patients were included in the study. The mean age of the patients was 46.9±22.4 (range, 7-96) and 91 were female (57.6%). In Set 1, 138 (55.2%) eyes had active uveitis; the localization was anterior in 58 (42.0%), posterior in 53 (38.4%), and anterior + posterior in 27 (19.6%) eyes. In Set 2, 169 eyes of 107 patients had active anterior, posterior or pan-uveitis. The localization was anterior in 27 (16%) eyes, posterior in 84 (49.7%) eyes and anterior + posterior in 58 (34.3%) eyes. Assessment with Set 2 identified additional 31 (18.3%) eyes with active disease (p=0.006), and additional 31 (18.3%) eyes having disease in both anterior+posterior segments (p<0.001). Fleiss’ kappa statistics demonstrated good inter-grader agreement within both Set 1 and Set 2. Management was changed in 68 (27.4%) eyes in Set 2, compared with Set 1.

Conclusions : Baseline UWFFA may alter the assessment of disease activity, localization, and management decisions compared to clinical examination with only UWFFP and SD-OCT. Thus, baseline UWFFA may serve as essential tool in the evaluation of uveitis patients.

This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
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Copyright © 2025 Association for Research in Vision and Ophthalmology.
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