Abstract
Presentation Description :
ZIKV infection encompasses a broad and intricate spectrum of ocular pathologies including conjunctivitis, uveitis, maculopathy, macular edema, chorioretinal atrophy, along with changes in the retinal vasculature, and optic neuropathy. However, the molecular and cellular basis of these ocular complications of ZIKV remains elusive. To study ZIKV pathogenesis in the eye, our laboratory has developed in vitro, in vivo, and retinal organoid models. Our most recent transcriptomic studies of ZIKV-infected RPE cells revealed an important role of cellular metabolism (e.g., lipids, and energy) in regulating ZIKV replication and the modulation of antiviral response. The ocular manifestations of ZIKV not only underscore the impact of systemic infection with several other emerging and re-emerging RNA virus infections, like SARS-CoV-2, emphasizing the need for comprehensive strategies to prevent, diagnose, and manage these emerging infections.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.