Abstract
Purpose :
We aimed to investigate the imaging and clinical features of polypoidal choroidal vasculopathy (PCV) with or without the pulsation of polyp.
Methods :
All the PCV eyes were classified into pulsatile and non-pulsatile PCV groups according to the pulsation of the polyp on indocyanine green angiography (ICGA). On ICGA video, the initial and complete dye filling time of the polyp was evaluated. On the optical coherence tomography (OCT) images, maximal pigment epithelial detachment (PED) height, central retinal thickness, subfoveal Haller layer thickness, and subfoveal choroidal thickness were measured. Clinical features including best-corrected visual acuity, subretinal hemorrhage, and intravitreal injection number were evaluated.
Results :
A total of 75 eyes were classified into the pulsatile PCV (30 eyes) or the non-pulsatile PCV (45 eyes) groups based on the ICGA video. The initial and complete filling times of the polyp in the pulsatile PCV group (2.59 ± 0.93 and 8.33 ± 3.42 seconds) were shorter than those in the non-pulsatile PCV group (4.11 ± 1.87 and 10.63 ± 3.81 seconds, p < 0.001 and p = 0.010, respectively). The maximal PED height in the pulsatile PCV group (414.90 ± 377.15 µm) was greater than that in the non-pulsatile PCV group (247.81 ± 164.07 µm, p = 0.030). The pulsatile PCV group showed a higher prevalence of subretinal hemorrhage (43.33%) after intravitreal injection than the non-pulsatile PCV group (13.95%, p = 0.005) during 12 months. The mean injection number during 12 months of the pulsatile PCV group (5.48 ± 1.46) was greater than that of the non-pulsatile PCV group (4.09 ± 1.21, p < 0.001).
Conclusions :
Eyes with pulsatile PCV showed shorter filling time of the polyp, greater PED height, higher prevalence of subretinal hemorrhage, and needed more intravitreal injection numbers during 12 months. These might suggest that PCV has distinct imaging and clinical features according to the polyp pulsation.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.