Abstract
Purpose :
The anterior uveitis associated with herpes zoster virus (VZV-AU) is classified into two types: those with associated ocular herpes zoster (Herpes Opthalmicus : HO) and those without (Zoster Sine Herpete : ZSH). In this study, we investigated the association between patient backgrounds and ocular findings in VZVAU, including a comparison between HO and ZSH.
Methods :
We retrospectively investigated the medical records of 47 patients (47 eyes) with VZVAU who were diagnosed and treated at our hospital. Patient demographics, visual acuity, intraocular pressure (IOP), history of ocular herpes zoster (OS) and ocular hypertension (OH), mutton-fat keratoprecipitates (Kp), Descemet's fold (DF), anterior chamber inflammation (AC), iris atrophy, cataract, antiviral medication use, VZVAU recurrence, secondary glaucoma, cataract surgery, and glaucoma surgery were reviewed.
Results :
The mean age was 66.9 ± 15.5 years, with a male-to-female ratio of 21:26. The mean follow-up period was 16.9 ± 26.0 months. The prevalence of OS was 55.3%, OH was 55.3%, Kp was 66.0%, DF was 27.1%, AC was 89.6%, iris atrophy was 14.6%, cataract was 73.0%, antiviral drug use was 83.3%, recurrence rate was 20.8%, secondary glaucoma was 36.2%, cataract surgery was 26.5%, and glaucoma surgery was 8.2%. In a multivariate regression analysis with OS as the outcome variable, only mutton-fat Kp was associated as a negative factor (OR 0.197; 95% CI 0.04 – 0.92). In a subsequent comparison of HO (n = 26) and ZSH (n = 21) patients, frequency of mutton-fat Kp was significantly higher in ZSH patients than in HO patients, but no significant difference was found in the final visit LogMAR VA and IOP.
Conclusions :
VZV-AU was more severe in the ZSH group than in the HO group, but the visual prognosis after treatment was similar in both groups.
This abstract was presented at the 2024 ARVO Annual Meeting, held in Seattle, WA, May 5-9, 2024.