Abstract
Purpose :
To develop various imaging techniques to uncover the full mechanism of accommodation, the pathophysiology of presbyopia, the potential links to glaucoma and to test various presbyopia therapies.
Methods :
To develop various imaging techniques to uncover the full mechanism of accommodation, the pathophysiology of presbyopia, the potential links to glaucoma and to test various presbyopia therapies. Methods. We studied the entire globe of the eye at rest and during pharmacological (human and rhesus monkey) and central-electrical stimulation (monkey), inducing accommodative responses to discern function of the various intraocular structures and their age related decline (presbyopia). Contrast agents were utilized (Triamcinolone) to visualize the vitreous strands in monkeys. Accommodative movements of the lens, ciliary muscle, zonula and intravitreal structures were measured by ultrasound biomicroscopy (UBM; 50, 20 MHz) and choroidal movements in the region of the optic nerve were measured by OCT. Goniovideography and Scheimpflug imaging were also used to image the movements of the ciliary muscle and the lens. Accommodative amplitude was measured by Hartinger coincidence refractometry.
Results :
These imaging techniques can be used to measure and quantify the accommodative movements of the lens, ciliary muscle, intravitreal strands, zonula and structures (i.e. Cloquet’s Canal) and choroid. Resulting images will be presented.
Conclusions :
Dynamic movements of the accommodative apparatus in the anterior and posterior segments provide transformative information to the field of accommodation and presbyopia. Accommodative movements of the lens, ciliary muscle, choroid, and vitreous can be related to accommodative amplitude. These techniques can be used to test various therapeutic interventions to restore accommodation in presbyopia (ie. IOLs, drug treatment). These studies provide insights into the mechanisms of accommodation, and perhaps glaucomatous optic neuropathy.
This abstract was presented at the 2024 ARVO Imaging in the Eye Conference, held in Seattle, WA, May 4, 2024.