Comparison between the Nidek MP-3 and CenterVue MAIA microperimetry devices in healthy and diseased eyes

Abstract

Purpose : To compare and correlate mean sensitivities obtained with the Nidek MP-3 and CenterVue MAIA microperimetry devices.

Methods : A prospective comparative cross-sectional study was conducted by enrolling subjects with normal eyes as well as diseased eyes of patients having Diabetes (DM) without Diabetic Retinopathy (DR), DR (varying in severity from mild non-proliferative DR to proliferative DR), and non-exudative Age-related Macular Degeneration (AMD). Patients underwent testing on both the Nidek MP-3 and the MAIA microperimetry devices, alternating the testing sequence using a pre-programmed 10-2 macular grid with 68 stimuli and other consistent parameters. To understand the relationship between the two devices, Bland-Altman repeatability analysis was conducted. Conversion formulas from MP-3 to MAIA were identified using both a shift method and a simple regression method. The coefficient of Repeatability (CoR) between MAIA and converted values from MP-3 were calculated to quantify absolute reliability and define the requirement for a clinically significant change that is beyond natural variability.

Results : 111 eyes from 80 subjects were enrolled with a mean age of 57.2 + 20.3 years. This cohort included 43 healthy eyes, 14 eyes with DM without DR, 32 eyes with DR, and 22 eyes with AMD. Two conversion formulas were developed. Using the shift and regression methods, MAIA_shift and MAIA_Reg values were derived, respectively. On Bland-Altman analysis, the majority of measured mean sensitivities for the healthy, DR, and AMD groups fell between the upper and lower limits of agreement. The healthy group data points closely follow the regression line, indicating a strong positive correlation between the measurements. In contrast, diseased eyes displayed variability, deviating from the regression line. The CoRs were 2.78 for MAIA vs. MAIA_shift and 2.71 for MAIA vs. MAIA_reg. The comparisons between each patient group and the healthy subjects remained consistent across all parameters (MAIA, MAIA converted from MP-3 using the shift method, MAIA converted from MP-3 using the simple regression method, and MP-3).

Conclusions : Retinal sensitivity measurements were consistently higher for MAIA than MP-3. Despite this, there was a stable correlation between the two devices. Limitations included a lack of randomization.

This abstract was presented at the 2024 ARVO Imaging in the Eye Conference, held in Seattle, WA, May 4, 2024.