Volume 63 Issue 8 | IOVS

Biochemistry and Molecular Biology

Hypoxia-Induced Scleral HIF-2α Upregulation Contributes to Rises in MMP-2 Expression and Myopia Development in Mice Open Access

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Wenjing Wu; Yongchao Su; Changxi Hu; Huixin Tao; Ying Jiang; Guandong Zhu; Jiadi Zhu; Ying Zhai; Jia Qu; Xiangtian Zhou; Fei Zhao

Tags: gelatinase a, hypoxia, mice, myopia, sclera

Investigative Ophthalmology & Visual Science July 2022, Vol.63, 2. doi:https://doi.org/10.1167/iovs.63.8.2

High Glucose Aggravates Retinal Endothelial Cell Dysfunction by Activating the RhoA/ROCK1/pMLC/Connexin43 Signaling Pathway Open Access

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Hongran Zhao; Hui Kong; Wenjuan Wang; Tianran Chen; Yuting Zhang; Jing Zhu; Dandan Feng; Yan Cui

Tags: connexin 43, endothelial cells, glucose, pathophysiology, rhoa gtp-binding protein

Investigative Ophthalmology & Visual Science July 2022, Vol.63, 22. doi:https://doi.org/10.1167/iovs.63.8.22

Clinical and Epidemiologic Research

Peripheral Refraction With Toric Orthokeratology and Soft Toric Multifocal Contact Lenses in Myopic Astigmatic Eyes Open Access

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Erin S. Tomiyama; David A. Berntsen; Kathryn Richdale

Tags: astigmatism, contact lenses, eye, lens (device), lens, crystalline

Investigative Ophthalmology & Visual Science July 2022, Vol.63, 10. doi:https://doi.org/10.1167/iovs.63.8.10

Foveal Curvature and Its Associations in UK Biobank Participants Open Access

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Abraham Olvera-Barrios; Yuka Kihara; Yue Wu; Alasdair N. Warwick; Philipp L. Müller; Katie M. Williams; Alicja R. Rudnicka; Christopher G. Owen; Aaron Y. Lee; Catherine Egan; Adnan Tufail; on behalf of the UK Biobank Eyes and Vision Consortium

Tags: biobanks, ethnic group, income, eye, astigmatism

Investigative Ophthalmology & Visual Science July 2022, Vol.63, 26. doi:https://doi.org/10.1167/iovs.63.8.26

Cornea

Integrated Stress Response Regulation of Corneal Epithelial Cell Motility and Cytokine Production Open Access

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Hsiao-Sang Chu; Cornelia Peterson; Xitiz Chamling; Cynthia Berlinicke; Donald Zack; Albert S. Jun; James Foster

Tags: agonists, cell lines, cell motility, corneal epithelial cells, corneal epithelium

Investigative Ophthalmology & Visual Science July 2022, Vol.63, 1. doi:https://doi.org/10.1167/iovs.63.8.1

Altered Regulation of mRNA and miRNA Expression in Epithelial and Stromal Tissue of Keratoconus Corneas Open Access

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Tanja Stachon; Mahsa Nastaranpour; Berthold Seitz; Eckart Meese; Lorenz Latta; Suphi Taneri; Navid Ardjomand; Nóra Szentmáry; Nicole Ludwig

Tags: cornea, epithelium, micrornas, rna, messenger, keratoconus

Investigative Ophthalmology & Visual Science July 2022, Vol.63, 7. doi:https://doi.org/10.1167/iovs.63.8.7

The NLRP3 Activation in Infiltrating Macrophages Contributes to Corneal Fibrosis by Inducing TGF-β1 Expression in the Corneal Epithelium Open Access

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Jing Xu; Peng Chen; Xiaoyu Luan; Xinying Yuan; Susu Wei; Yaxin Li; Chuanlong Guo; Xianggen Wu; Guohu Di

Tags: cicatrix, cornea, fibrosis, macrophages, nlr family, pyrin domain-containing 3 protein

Investigative Ophthalmology & Visual Science July 2022, Vol.63, 15. doi:https://doi.org/10.1167/iovs.63.8.15

Labial Mucosa Stem Cells: Isolation, Characterization, and Their Potential for Corneal Epithelial Reconstruction Open Access

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Kirill E. Zhurenkov; Elga I. Alexander-Sinkler; Ilya O. Gavrilyik; Natalia M. Yartseva; Svetlana A. Aleksandrova; Tatiana V. Mashel; Julia I. Khorolskaya; Miralda I. Blinova; Alexei N. Kulikov; Sergei V. Churashov; Valery F. Chernysh; Natalia A. Mikhailova

Tags: cornea, epithelium, lip, mucous membrane, oryctolagus cuniculus

Investigative Ophthalmology & Visual Science July 2022, Vol.63, 16. doi:https://doi.org/10.1167/iovs.63.8.16

Genetics

Genomewide Association Study of Retinal Traits in the Amish Reveals Loci Influencing Drusen Development and Link to Age-Related Macular Degeneration Open Access

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Michael D. Osterman; Yeunjoo E. Song; Muneeswar Nittala; SriniVas R. Sadda; William K. Scott; Dwight Stambolian; Margaret A. Pericak-Vance; Jonathan L. Haines

Tags: age-related macular degeneration, drusen, genetics, genome-wide association study, genetic risk

Investigative Ophthalmology & Visual Science July 2022, Vol.63, 17. doi:https://doi.org/10.1167/iovs.63.8.17

Glaucoma

Crystallins Play a Crucial Role in Glaucoma and Promote Neuronal Cell Survival in an In Vitro Model Through Modulating Müller Cell Secretion Open Access

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Hanhan Liu; Katharina Bell; Anja Herrmann; Stefan Arnhold; Karl Mercieca; Fabian Anders; Kerstin Nagel-Wolfrum; Solon Thanos; Verena Prokosch

Tags: crystallins, glaucoma, alpha-crystallin b chain

Investigative Ophthalmology & Visual Science July 2022, Vol.63, 3. doi:https://doi.org/10.1167/iovs.63.8.3

Immunology and Microbiology

Apolipoprotein A1 Modulates Teff/Treg Balance Through Scavenger Receptor Class B Type I-Dependent Mechanisms in Experimental Autoimmune Uveitis Open Access

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Haixiang Huang; Zhuang Li; Jun Huang; Yanyan Xie; Zhiqiang Xiao; Yunwei Hu; Guanyu Chen; Minzhen Wang; Zuoyi Li; Qian Chen; Wenjie Zhu; Wenru Su; Yan Luo; Xiaoqing Chen; Dan Liang

Tags: apolipoprotein a-i, autoimmunity, balance, device, equilibrium, immune response

Investigative Ophthalmology & Visual Science July 2022, Vol.63, 23. doi:https://doi.org/10.1167/iovs.63.8.23

Lens

Lens Aquaporin-5 Inserts Into Bovine Fiber Cell Plasma Membranes Via Unconventional Protein Secretion Open Access

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Romell B. Gletten; Lee S. Cantrell; Sujoy Bhattacharya; Kevin L. Schey

Tags: cattle, cell membrane, lens (device), lens, crystalline, water channels

Investigative Ophthalmology & Visual Science July 2022, Vol.63, 5. doi:https://doi.org/10.1167/iovs.63.8.5

Multidisciplinary Ophthalmic Imaging

Functional Changes Within the Rod Inner Segment Ellipsoid in Wildtype Mice: An Optical Coherence Tomography and Electron Microscopy Study Open Access

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Bruce A. Berkowitz; Robert H. Podolsky; Karen Lins Childers; Tom Burgoyne; Giulia De Rossi; Haohua Qian; Robin Roberts; Ryan Katz; Rida Waseem; Cole Goodman

Tags: mice, mitochondria, optical coherence tomography, rod photoreceptors, shape

Investigative Ophthalmology & Visual Science July 2022, Vol.63, 8. doi:https://doi.org/10.1167/iovs.63.8.8

Photoreceptor and Retinal Pigment Epithelium Relationships in Eyes With Vitelliform Macular Dystrophy Revealed by Multimodal Adaptive Optics Imaging Open Access

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Tao Liu; Nancy Aguilera; Andrew J. Bower; Joanne Li; Ehsan Ullah; Alfredo Dubra; Catherine Cukras; Brian P. Brooks; Brett G. Jeffrey; Robert B. Hufnagel; Laryssa A. Huryn; Wadih M. Zein; Johnny Tam

Tags: diagnostic imaging, eye, retinal cone, vitelliform dystrophy, optics

Investigative Ophthalmology & Visual Science July 2022, Vol.63, 27. doi:https://doi.org/10.1167/iovs.63.8.27

Retina

Choroideremia Carriers: Dark-Adapted Perimetry and Retinal Structures Open Access

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Rait Parmann; Vivienne C. Greenstein; Stephen H. Tsang; Janet R. Sparrow

Tags: choroideremia, perimetry, eye, mosaicism, diagnostic imaging

Investigative Ophthalmology & Visual Science July 2022, Vol.63, 4. doi:https://doi.org/10.1167/iovs.63.8.4

Effects of Monocular Light Deprivation on the Diurnal Rhythms in Retinal and Choroidal Thickness Open Access

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Linjiang Lou; Lisa A. Ostrin

Tags: circadian rhythms, eye, photoreceptors, light exposure

Investigative Ophthalmology & Visual Science July 2022, Vol.63, 6. doi:https://doi.org/10.1167/iovs.63.8.6

Interleukin-19 Promotes Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy Open Access

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Jingling Zou; Wei Tan; Bingyan Li; Zicong Wang; Yun Li; Jun Zeng; Bing Jiang; Shigeo Yoshida; Yedi Zhou

Tags: interleukin-19, mice, retinal neovascularization, oxygen, macrophages

Investigative Ophthalmology & Visual Science July 2022, Vol.63, 9. doi:https://doi.org/10.1167/iovs.63.8.9

Efficacy of an Anti-Semaphorin 3A Neutralizing Antibody in a Male Experimental Retinal Vein Occlusion Mouse Model Open Access

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Shinsuke Nakamura; Anri Nishinaka; Yae Hidaka; Masamitsu Shimazawa; Leo Thomas; Remko A. Bakker; Hideaki Hara

Tags: mice, neutralizing antibodies, semaphorin-3a, semaphorins, antibodies

Investigative Ophthalmology & Visual Science July 2022, Vol.63, 14. doi:https://doi.org/10.1167/iovs.63.8.14

Delineating the Clinical Phenotype of Patients With the c.629C>G, p.Pro210Arg Mutation in Peripherin-2 Open Access

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Shannon M. Conley; Cynthia K. McClard; Maggie L. Mwoyosvi; Niyaf Alkadhem; Bojana Radojevic; Martin Klein; David Birch; Ashley Ellis; Sonny W. Icks; Tejesh Guddanti; Lea D. Bennett

Tags: mutation, phenotype, proteins, retina

Investigative Ophthalmology & Visual Science July 2022, Vol.63, 19. doi:https://doi.org/10.1167/iovs.63.8.19

Quantitative Evaluations of Posterior Staphylomas in Highly Myopic Eyes by Ultra-Widefield Optical Coherence Tomography Open Access

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Noriko Nakao; Tae Igarashi-Yokoi; Hiroyuki Takahashi; Shiqi Xie; Kosei Shinohara; Kyoko Ohno-Matsui

Tags: eye, optical coherence tomography, staphyloma, shape

Investigative Ophthalmology & Visual Science July 2022, Vol.63, 20. doi:https://doi.org/10.1167/iovs.63.8.20

EGF Receptor Signaling Modulates YAP Activation and Promotes Experimental Proliferative Vitreoretinopathy Open Access

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Wei Zhang; Jing Li

Tags: epidermal growth factor receptors, signal transduction, vitreoretinopathy, proliferative

Investigative Ophthalmology & Visual Science July 2022, Vol.63, 24. doi:https://doi.org/10.1167/iovs.63.8.24

LGALS3BP in Microglia Promotes Retinal Angiogenesis Through PI3K/AKT Pathway During Hypoxia Open Access

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Chenyang Zhao; Yusen Liu; Jiayu Meng; Xiaotang Wang; Xianyang Liu; Wanqian Li; Qian Zhou; Junjie Xiang; Na Li; Shengping Hou

Tags: 1-phosphatidylinositol 3-kinase, akt signaling pathway, angiogenesis, hypoxia, microglia

Investigative Ophthalmology & Visual Science July 2022, Vol.63, 25. doi:https://doi.org/10.1167/iovs.63.8.25

Retinal Cell Biology

Multiple Invagination Patterns and Synaptic Efficacy in Primate and Mouse Rod Synaptic Terminals Open Access

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Yoshihiko Tsukamoto; Naoko Omi

Tags: invagination, macaca, mice, rod photoreceptors, dendrites

Investigative Ophthalmology & Visual Science July 2022, Vol.63, 11. doi:https://doi.org/10.1167/iovs.63.8.11

Visual Neuroscience

Deletion of Protein Phosphatase 2A Accelerates Retinal Degeneration in GRK1- and Arr1-Deficient Mice Open Access

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Alexander V. Kolesnikov; Jennings Luu; Hui Jin; Krzysztof Palczewski; Vladimir J. Kefalov

Tags: mice, retinal degeneration, protein phosphatase, retina, rod photoreceptors

Investigative Ophthalmology & Visual Science July 2022, Vol.63, 18. doi:https://doi.org/10.1167/iovs.63.8.18

Review

Evidence Suggesting the Role of Gut Dysbiosis in Diabetic Retinopathy Open Access

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Pratima Singh Thakur; David Aggarwal; Brijesh Takkar; Sisinthy Shivaji; Taraprasad Das

Tags: diabetic retinopathy, dysbiosis, intestinal bacteria, retina

Investigative Ophthalmology & Visual Science July 2022, Vol.63, 21. doi:https://doi.org/10.1167/iovs.63.8.21

Erratum

Erratum in: Cortical Atrophy Predicts Visual Performance in Long-Term Central Retinal Disease; GCL, pRNFL and Cortical Thickness Are Key Biomarkers Open Access

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Investigative Ophthalmology & Visual Science July 2022, Vol.63, 12. doi:https://doi.org/10.1167/iovs.63.8.12

Erratum in: Sleep Loss Causes Dysfunction in Murine Extraorbital Lacrimal Glands Open Access

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Investigative Ophthalmology & Visual Science July 2022, Vol.63, 13. doi:https://doi.org/10.1167/iovs.63.8.13

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