Current Issue | IOVS | ARVO Journals

Nicotinamide N-Methyltransferase in the Inflammatory Pathogenesis of Graves’ Orbitopathy Open Access

Dayoon Cho; Soo Hyun Choi; Jin Sook Yoon; JaeSang Ko

Tags: cytokine, fibroblasts, inflammation, methyltransferase, niacinamide

Investigative Ophthalmology & Visual Science May 2025, Vol.66, 3. doi:https://doi.org/10.1167/iovs.66.5.3

Regulatory Effects of the Wnt7b/β-Catenin/MMP-2 Signaling Pathway on Scleral Stiffness in Guinea Pigs With Form-Deprivation Myopia Open Access

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Binyu Wen; Hangyu Li; Hui Tao; Hong Ren; Bosheng Ma; Mengdi Shi; Shen Chen; Jiaqi Du; Ziyi Cai; Jing Zhang; Dongshi Guan; Zhihong Deng

Tags: caviidae, collagen, gelatinase a, myopia, sclera

Investigative Ophthalmology & Visual Science May 2025, Vol.66, 19. doi:https://doi.org/10.1167/iovs.66.5.19

Canonical and Truncated Transglutaminase-2 Drive TGF-β1 Autocrine Loop to Induce Fibrosis in Graves’ Orbitopathy Open Access

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Xiaoli Bao; Zhihui Xu; Xi Wang; Te Zhang; Xiaotong Sha; Anqi Sun; Huijing Ye; Huasheng Yang

Tags: fibrosis, protein glutamine gamma glutamyltransferase 2, autocrine, genes

Investigative Ophthalmology & Visual Science May 2025, Vol.66, 22. doi:https://doi.org/10.1167/iovs.66.5.22

Clinical and Epidemiologic Research

Three-Year Change in Subfoveal Choroidal Thickness and Area With Multifocal Contact Lens Wear in the Bifocal Lenses in Nearsighted Kids (BLINK) Study Open Access

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Maria K. Walker; David A. Berntsen; Matt L. Robich; Rachel L. Fenton; Anita Ticak; Justina R. Assaad; Hope M. Queener; Stephanie J. Chiu; Sina Farsiu; Donald O. Mutti; Lisa A. Jones-Jordan; Jeffrey J. Walline; for the BLINK Study Group

Tags: child, choroid, contact lenses, lens (device), lens, crystalline

Investigative Ophthalmology & Visual Science May 2025, Vol.66, 5. doi:https://doi.org/10.1167/iovs.66.5.5

Spatial and Temporal Changes in Choroid Morphology Associated With Long-Duration Spaceflight Open Access

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Charles Bélanger Nzakimuena; Marissé Masís Solano; Rémy Marcotte-Collard; Mark Richard Lesk; Santiago Costantino

Tags: choroid, space flight, language morphology, morphology

Investigative Ophthalmology & Visual Science May 2025, Vol.66, 17. doi:https://doi.org/10.1167/iovs.66.5.17

Cornea

Retinoic Acid Receptor Alpha- and Beta-Mediated Signaling Regulates Conjunctival Epithelial Cell Keratinization Open Access

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Hokoru Yoshioka; Mayumi Ueta; Seiichi Yokoo; Norihiko Yokoi; Katsura Mizushima; Yuji Naito; Shigeru Kinoshita; Chie Sotozono

Tags: conjunctival epithelial cells, keratinization, retinoic acid receptor, retinoic acid receptor alpha, signal transduction

Investigative Ophthalmology & Visual Science May 2025, Vol.66, 6. doi:https://doi.org/10.1167/iovs.66.5.6

Targeting α7 Nicotinic Acetylcholine Receptor for Modulating the Neuroinflammation of Dry Eye Disease Via Macrophages Open Access

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Xujiao Zhou; Yuqing Wu; Yirou Zhang; Binbin Chu; Kan Yang; Jiaxu Hong; Yao He

Tags: agonists, cornea, dry eye syndromes, inflammation, macrophages

Investigative Ophthalmology & Visual Science May 2025, Vol.66, 13. doi:https://doi.org/10.1167/iovs.66.5.13

Autophagy Impairment-Derived SQSTM1 Accumulation Promotes Ferroptosis in Corneal Epithelial Cells Through ACSL4 in Dry Eye Open Access

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Runze Zhang; Lihong Liang; Kai Liao; Hao Zeng; Xue Yang; Xiaoran Wang; Bowen Wang; Jin Yuan

Tags: corneal epithelial cells, dry eye syndromes, ferroptosis, stress, autophagy

Investigative Ophthalmology & Visual Science May 2025, Vol.66, 23. doi:https://doi.org/10.1167/iovs.66.5.23

Genetics

Systematic Ocular Phenotyping of Knockout Mouse Lines Identifies Genes Associated With Age-Related Corneal Dystrophies Open Access

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Andrew Briere; Peter Vo; Benjamin Yang; David Adams; Takanori Amano; Oana Amarie; Zorana Berberovic; Lynette Bower; Steve D. M. Brown; Samantha Burrill; Soo Young Cho; Sharon Clementson-Mobbs; Abigail D'souza; Mohammad Eskandarian; Ann M. Flenniken; Helmut Fuchs; Valerie Gailus-Durner; Yann Hérault; Martin Hrabe de Angelis; Shundan Jin; Russell Joynson; Yeon Kyung Kang; Haerim Kim; Hiroshi Masuya; Hamid Meziane; Ki-Hoan Nam; Hyuna Noh; Lauryl M. J. Nutter; Marcela Palkova; Jan Prochazka; Miles Joseph Raishbrook; Fabrice Riet; Jason Salazar; Radislav Sedlacek; Mohammed Selloum; Kyoung Yul Seo; Je Kyung Seong; Hae-Sol Shin; Toshihiko Shiroishi; Michelle Stewart; Karen Svenson; Masaru Tamura; Heather Tolentino; Sara Wells; Wolfgang Wurst; Atsushi Yoshiki; Louise Lanoue; K. C. Kent Lloyd; Brian C. Leonard; Michel J. Roux; Colin McKerlie; Ala Moshiri; for The International Mouse Phenotyping Consortium

Tags: genes, hereditary corneal dystrophy, mice, knockout, phenotype determination, proteins

Investigative Ophthalmology & Visual Science May 2025, Vol.66, 7. doi:https://doi.org/10.1167/iovs.66.5.7

Immunology and Microbiology

Comparative Efficacy of Interleukin-7 and -15 Blockade in Alleviating Experimental Chronic Uveitis and Suppressing Pathogenic Memory CD4⁺ T Cells Open Access

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Qiurong Zhu; Maryam Shayan; Rachel M. Huckfeldt; Yihe Chen

Tags: interleukin-15, interleukin-7, memory, t-lymphocytes, uveitis

Investigative Ophthalmology & Visual Science May 2025, Vol.66, 9. doi:https://doi.org/10.1167/iovs.66.5.9

Contribution of Leukocidin ED to the Pathogenesis of Staphylococcus aureus Endophthalmitis Open Access

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Luis Longoria-Gonzalez; Phillip S. Coburn; Roger Astley; Yan Chen; Michelle C. Callegan

Tags: endophthalmitis, eye, infections, mice, pathogenesis

Investigative Ophthalmology & Visual Science May 2025, Vol.66, 11. doi:https://doi.org/10.1167/iovs.66.5.11

Lens

RNA-Seq Study of Human Lens Epithelial Cells: Differentially Expressed Genes and Pathways in Steroid, Uveitic, Post-Vitrectomy, and Senile Cataracts Open Access

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Carrie Fei; Michael R. Dong; Sean Byars; Jaynish S. Shah; Anthony J. Hall; Lyndell L. Lim

Tags: after-cataract, cataract, cataract, senile, epithelial cells, genes

Investigative Ophthalmology & Visual Science May 2025, Vol.66, 4. doi:https://doi.org/10.1167/iovs.66.5.4

Cholesterol and Q147E Deamidation Modulates αA-Crystallin Membrane Binding Elucidating Protective Role of Lens Membrane Composition Changes With Aging Open Access

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Preston Hazen; Nawal K. Khadka; Laxman Mainali

Tags: crystallins, lens (device), lens, crystalline, tissue membrane, cholesterol

Investigative Ophthalmology & Visual Science May 2025, Vol.66, 8. doi:https://doi.org/10.1167/iovs.66.5.8

LncRNA HOTAIR Interaction With WTAP Promotes m⁶A Methyltransferase Complex Assembly and Posterior Capsule Opacification Formation by Increasing THBS1 Open Access

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Xi Chen; Chenshuang Li; Jiankui Li; Zaoxia Guo; Siqi Zhang; Chenjun Guo; Hong Yan

Tags: after-cataract, epithelial to mesenchymal transition, methyltransferase, proteins, rna

Investigative Ophthalmology & Visual Science May 2025, Vol.66, 20. doi:https://doi.org/10.1167/iovs.66.5.20

Retina

Complement C3/C3aR Signaling Pathway Inhibition Ameliorates Retinal Damage in Experimental Retinal Vein Occlusion Open Access

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Yanying Zhao; Zhengwei Ge; Tingting Guo; Hengwei Liu; Yufan Zhou; Juan Chen; Heping Xu; Zhongping Chen

Tags: complement 3, lasers, mice, retinal vein occlusion, signal pathway

Investigative Ophthalmology & Visual Science May 2025, Vol.66, 2. doi:https://doi.org/10.1167/iovs.66.5.2

Aqueous Humor Levels of Vascular Endothelial Growth Factor in Patients With Dry Age-Related Macular Degeneration and Subretinal Drusenoid Deposits Open Access

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Eun Gyu Yoon; Ki Tae Nam; Mihyun Choi; Kwang-Eon Choi; Cheolmin Yun

Tags: age-related macular degeneration, aqueous humor, vascular endothelial growth factor a, drusen

Investigative Ophthalmology & Visual Science May 2025, Vol.66, 10. doi:https://doi.org/10.1167/iovs.66.5.10

Endoplasmic Reticulum Stress Drives Neuroinflammation Through Lipocalin 2 Upregulation in Retinal Microglia After Optic Nerve Injury Open Access

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Weifeng Huang; Yaoming Liu; Jinmiao Li; Yang Gao; Junjie Tang; Siuhang Yip; Xinyue Wang; Hongwei Zhang; Yujun Ma; Shicai Su; Jiahe Nie; Rong Lu

Tags: endoplasmic reticulum stress, lipocalin-2 protein, microglia, neuroinflammatory diseases, optic nerve injuries

Investigative Ophthalmology & Visual Science May 2025, Vol.66, 12. doi:https://doi.org/10.1167/iovs.66.5.12

Chemokine System Changes Drive Age-Related Macular Degeneration and Influence Treatment Outcomes Open Access

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Alexander Kai Thomsen; Maria Abildgaard Steffensen; Amalie Thomsen Nielsen; Henrik Vorum; Bent Honoré; Mogens Holst Nissen; Torben Lykke Sørensen

Tags: age-related macular degeneration, chemokines, treatment outcome, chemokine receptors

Investigative Ophthalmology & Visual Science May 2025, Vol.66, 14. doi:https://doi.org/10.1167/iovs.66.5.14

Glucagon-Like Peptide 1 Receptor Agonist Stimulation Inhibits Laser-Induced Choroidal Neovascularization by Suppressing Intraocular Inflammation Open Access

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Akira Machida; Keiji Suzuki; Takafumi Nakayama; Sugao Miyagi; Yuki Maekawa; Ryuya Murakami; Masafumi Uematsu; Takashi Kitaoka; Akio Oishi

Tags: choroidal neovascularization, lasers, inflammation, nlr family, pyrin domain-containing 3 protein, agonists

Investigative Ophthalmology & Visual Science May 2025, Vol.66, 15. doi:https://doi.org/10.1167/iovs.66.5.15

High Resolution Imaging and Fixation Analysis of Eccentric Preferred Retinal Loci in Macular Diseases Open Access

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Olubayo U. Kolawole; Ethan Bensinger; Jessica Wong; Nicholas Rinella; Katharina G. Foote; Hao Zhou; Ruikang K. Wang; Jacque L. Duncan; Austin Roorda

Tags: diagnostic imaging, eye, macular disorders, atrophoderma maculatum, retinal cone

Investigative Ophthalmology & Visual Science May 2025, Vol.66, 18. doi:https://doi.org/10.1167/iovs.66.5.18

Muscone Attenuates Uveitis Through the PI3K/AKT Signaling Pathway Open Access

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Xianyang Liu; Hangjia Zuo; Chao Wu; Na Li; Qian Zhou; Fan Cao; Baorui Chu; Shuhao Zeng; Hui Feng; Yakun Wang; Fengyang Lei; Ke Hu; Shengping Hou

Tags: akt signaling pathway, mice, phosphoinositide 3-kinase, proteins, uveitis

Investigative Ophthalmology & Visual Science May 2025, Vol.66, 21. doi:https://doi.org/10.1167/iovs.66.5.21

Visual Neuroscience

Comparison of Physiological Brain Responses Evoked by Visual and Electrical Stimulation Open Access

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Katarzyna Kordecka; Ewa Kublik; Andrzej T. Foik

Tags: brain, electric stimulation, rats, visual system, evoked potentials

Investigative Ophthalmology & Visual Science May 2025, Vol.66, 1. doi:https://doi.org/10.1167/iovs.66.5.1

Erratum

Erratum in: Enlarged Blind Spot Linked to Gamma Zone and Peripapillary Hyperreflective Ovoid Mass-Like Structures in Non-Pathological Highly Myopic Eyes Open Access

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Investigative Ophthalmology & Visual Science May 2025, Vol.66, 16. doi:https://doi.org/10.1167/iovs.66.5.16

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