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Anatomy and Pathology/Oncology

Human Extraocular Muscles: Unique Pattern of Myosin Heavy Chain Expression during Myotube Formation Free
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Fatima Pedrosa–Domellöf; Ylva Holmgren; Christine Angela Lucas; Joseph Foon Yoon Hoh; Lars-Eric Thornell
Tags: limb, muscle, muscle fibers, muscle of orbit, myosin heavy chains
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1608-1616. doi:
Immunohistochemical Localization of NQO1 in Epithelial Dysplasia and Neoplasia and in Donor Eyes Free
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Lee P. Schelonka; David Siegel; Matthew W. Wilson; Alex Meininger; David Ross
Tags: body tissue, donors, eye, intraepithelial neoplasia, neoplasms
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1617-1622. doi:

Biochemistry and Molecular Biology

Changes in Retinal and Choroidal Gene Expression during Development of Refractive Errors in Chicks Free
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Marita P. Feldkaemper; Hong-Yan Wang; Frank Schaeffel
Tags: differential display technique, gene expression, lens (device), lens, crystalline, northern blotting
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1623-1628. doi:
Distribution of Glucocorticoid and Mineralocorticoid Receptors and 11β-Hydroxysteroid Dehydrogenases in Human and Rat Ocular Tissues Free
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John Stokes; June Noble; Lawrence Brett; Calbert Phillips; Jonathan R. Seckl; Colm O’Brien; Ruth Andrew
Tags: body tissue, eye, glucocorticoids, hydroxysteroids, in situ hybridization
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1629-1638. doi:
Proteoglycan Composition in the Human Sclera During Growth and Aging Free
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Jody A. Rada; Virginia R. Achen; Sudhir Penugonda; Robb W. Schmidt; Bobbie A. Mount
Tags: proteoglycan, sclera, aging
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1639-1648. doi:
Coexpression of VEGF Receptors VEGF-R2 and Neuropilin-1 in Proliferative Diabetic Retinopathy Free
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Susumu Ishida; Kei Shinoda; Shinichi Kawashima; Yoshihisa Oguchi; Yasunori Okada; Eiji Ikeda
Tags: coefficient of determination, neuropilin-1, proliferative diabetic retinopathy, transverse spin relaxation rate, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1649-1656. doi:
Retinal Ganglion Cells Recognized by Serum Autoantibody against γ-Enolase Found in Glaucoma Patients Free
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Ikuyo Maruyama; Hiroshi Ohguro; Yoko Ikeda
Tags: antibodies, autoantibodies, enolase, glaucoma, retinal ganglion cells
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1657-1665. doi:

Cornea

Mikulicz’s Disease and Sjögren’s Syndrome Free
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Kazuo Tsubota; Hiromi Fujita; Kensei Tsuzaka; Tsutomu Takeuchi
Tags: biopsy, lacrimal gland, mikulicz disease, sjogren's syndrome, lymphocytes
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1666-1673. doi:
Epithelialization of a Synthetic Polymer in the Feline Cornea: a Preliminary Study Free
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Margaret D. M. Evans; Ruo Zhong Xie; Mirella Fabbri; Michele C. Madigan; Hassan Chaouk; Gerrit J. Beumer; Gordon F. Meijs; Hans J. Griesser; John G. Steele; Deborah F. Sweeney
Tags: cats, cornea, epithelialization, epithelium, polymers
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1674-1680. doi:
Ascorbic Acid Content of Human Corneal Epithelium Free
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Richard F. Brubaker; William M. Bourne; Lori A. Bachman; Jay W. McLaren
Tags: ascorbic acid, corneal epithelium, mass or substance concentration per volume
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1681-1683. doi:
Flow Cytometry Measurements of DNA Content in Primary and Recurrent Pterygia Free
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Donald Tiang-Hwee Tan; Yan-Ping Liu; Li Sun
Tags: flow cytometry, ploidies, pterygium, recurrence, conjunctiva
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1684-1686. doi:
Hydrogel Lens Monomer Constituents Modulate Protein Sorption Free
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Qian Garrett; Bronwyn Laycock; R. Wayne Garrett
Tags: hydrogel, hydrogels, lens (device), lens, crystalline, proteins
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1687-1695. doi:
Increased Platelet-Activating Factor Receptor Gene Expression by Corneal Epithelial Wound Healing Free
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Xiang Ma; Haydee E. P. Bazan
Tags: cornea, epithelium, gene expression, oryctolagus cuniculus, platelet activating factor
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1696-1702. doi:
Regulation of MMP-9 Activity in Human Tear Fluid and Corneal Epithelial Culture Supernatant Free
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Lucia Sobrin; Zuguo Liu; Dagoberto C. Monroy; Abraham Solomon; Marie G. Selzer; Balakrishna L. Lokeshwar; Stephen C. Pflugfelder
Tags: cornea, epithelium, gelatinase b, stromelysin 1, tissue-inhibitor of metalloproteinase-1
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1703-1709. doi:

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Clinical Significance of Saccade Analysis in Early Active Graves’ Ophthalmopathy Free
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Hermann Dieter Schworm; Armin Ernst Heufelder; Andrea Kunze; Esther Welge; Klaus–Peter Boergen
Tags: graves' ophthalmopathy, saccades, eye movement, fatigue
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1710-1718. doi:
Co-Development of VEP Motion Response and Binocular Vision in Normal Infants and Infantile Esotropes Free
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Eileen E. Birch; Sherry Fawcett; David Stager
Tags: evoked potentials, visual, infant, motion, vision, binocular, infantile esotropia
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1719-1723. doi:

Glaucoma

mRNA In Situ Hybridization of TIGR/MYOC in Human Trabecular Meshwork Free
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Xiaofang Wang; Douglas H. Johnson
Tags: body tissue, eye, in situ hybridization, myoc gene, paraffin
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1724-1729. doi:
Automated Analysis of Normal and Glaucomatous Optic Nerve Head Topography Images Free
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Nicholas V. Swindale; Gordana Stjepanovic; Adeline Chin; Frederick S. Mikelberg
Tags: glaucoma, optic disk
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1730-1742. doi:
Direct Effects of Muscarinic Agents on the Outflow Pathways in Human Eyes Free
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Kristine A. Erickson; Alison Schroeder
Tags: eye, pilocarpine
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1743-1748. doi:
Latrunculins’ Effects on Intraocular Pressure, Aqueous Humor Flow, and Corneal Endothelium Free
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Jennifer A. Peterson; Baohe Tian; Jay W. McLaren; William C. Hubbard; Benjamin Geiger; Paul L. Kaufman
Tags: aqueous humor, cornea, corneal endothelium, eye, fluid flow
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1749-1758. doi:
NO/cGMP Pathway Activation and Membrane Potential Depolarization in Pig Ciliary Epithelium Free
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Johannes C. Fleischhauer; Jean-Louis Bény; Josef Flammer; Ivan O. Haefliger
Tags: ciliary epithelium, current good manufacturing practice, cyclic gmp, depolarization, membrane potentials
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1759-1763. doi:
Ranking of Optic Disc Variables for Detection of Glaucomatous Optic Nerve Damage Free
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Jost B. Jonas; Antonio Bergua; Paul Schmitz–Valckenberg; Konstantinos I. Papastathopoulos; Wido M. Budde
Tags: glaucoma, optic disk, optic nerve, neuroretinal rim, atrophy
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1764-1773. doi:
Scaling the Hill of Vision: The Physiological Relationship between Light Sensitivity and Ganglion Cell Numbers Free
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David F. Garway–Heath; Joseph Caprioli; Fred W. Fitzke; Roger A. Hitchings
Tags: cell count, ganglia, photophobia, vision
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1774-1782. doi:
Visual Function–Specific Perimetry for Indirect Comparison of Different Ganglion Cell Populations in Glaucoma Free
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Pamela A. Sample; Charles F. Bosworth; Eytan Z. Blumenthal; Christopher Girkin; Robert N. Weinreb
Tags: eye, ganglia, glaucoma, perimetry, vision
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1783-1790. doi:
Glaucoma in Primates: Cytochrome Oxidase Reactivity in Parvo- and Magnocellular Pathways Free
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Morris L. J. Crawford; Ronald S. Harwerth; Earl L. Smith, III; Fran Shen; Louvenia Carter–Dawson
Tags: glaucoma, cercopithecidae, cytochrome c oxidase, primary visual cortex
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1791-1802. doi:

Immunology and Microbiology

In Vitro Generation of Regulatory CD8+ T Cells Similar to those Found in Mice with Anterior Chamber–Associated Immune Deviation Free
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Takeshi Kezuka; J. Wayne Streilein
Tags: mice, ovum, picture exchange communication system, t-lymphocytes, anterior chamber of eye
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1803-1811. doi:
Reduced Leukocyte Migration, but Normal Rolling and Arrest, in Interleukin-8 Receptor Homologue Knockout Mice Free
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Matthias D. Becker; Leslie M. O’Rourke; Whitney S. Blackman; Stephen R. Planck; James T. Rosenbaum
Tags: immune reconstitution inflammatory syndrome, interleukin-8, leukocyte trafficking, leukocytes, mice, knockout
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1812-1817. doi:
Multiplex Polymerase Chain Reaction for Diagnosis of Viral and Chlamydial Keratoconjunctivitis Free
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Elfath M. Elnifro; Robert J. Cooper; Paul E. Klapper; Adrian C. Yeo; Andrew B. Tullo
Tags: chlamydia, keratoconjunctivitis, polymerase chain reaction, adenovirus infections, adenoviruses
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1818-1822. doi:
Recurrent Intraocular Inflammation in Endotoxin-Induced Uveitis Free
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Alexander T. Kozhich; Chi-Chao Chan; Igal Gery; Scott M. Whitcup
Tags: endotoxins, recurrence, uveitis, mice
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1823-1826. doi:
Xenoreactive CD4+ T Cells and Acute Rejection of Orthotopic Guinea Pig Corneas in Mice Free
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Kazumi Tanaka; Jun Yamada; J. Wayne Streilein
Tags: cornea, eye, guinea, mice, rejection (psychology)
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1827-1832. doi:

Lens

Inhibition of FGF-Induced αA-Crystallin Promoter Activity in Lens Epithelial Explants by TGFβ Free
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Yasuji Ueda; Coral G. Chamberlain; Kenshi Satoh; John W. McAvoy
Tags: crystallins, epithelium, lens (device), lens, crystalline, luciferases
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1833-1839. doi:
Overexpression of the Transforming Growth Factor-β–Inducible Gene βig-h3 in Anterior Polar Cataracts Free
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Eunjoo H. Lee; Young Seomun; Kyung–Hoon Hwang; Jung–Eun Kim; In–San Kim; Jae Ho Kim; Choun–Ki Joo
Tags: genes, polar cataract, protein overexpression, proteins, rna, messenger
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1840-1845. doi:
Steroid-Induced Short Term Diabetes in Chick Embryo: Reversible Effects of Insulin on Metabolic Changes and Cataract Formation Free
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Hiroshi Watanabe; Hiroshi Kosano; Hideo Nishigori
Tags: cataract, chick embryo, insulin, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1846-1852. doi:

Physiology and Pharmacology

Chloride Secretion by Bovine Ciliary Epithelium: a Model of Aqueous Humor Formation Free
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Chi-Wai Do; Chi-Ho To
Tags: aqueous humor, biological transport, bodily secretions, cattle, chlorides
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1853-1860. doi:
Mechanisms Mediating Substance P–Induced Contraction in the Rat Iris In Vitro Free
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Astor Grumann-Júnior; Marcos Antônio Dias; Ricardo Vieira Alves; Joel E. Boteon; João Batista Calixto
Tags: immune reconstitution inflammatory syndrome, iris, antagonists, substance p, mass or substance concentration per volume
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1861-1870. doi:
Pressure-Induced Myogenic Responses in Isolated Bovine Retinal Arteries Free
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Christophe Delaey; Johan Van de Voorde
Tags: cattle, central retinal artery, diameter, nifedipine, calcium
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1871-1875. doi:

Retina

Enhancement of Glucose Transport by Vascular Endothelial Growth Factor in Retinal Endothelial Cells Free
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Hirohito Sone; Baljit K. Deo; Arno K. Kumagai
Tags: endothelial cells, glucose transport, vascular endothelial growth factor a, tissue membrane
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1876-1884. doi:
Mechanisms of Hepatocyte Growth Factor–Induced Retinal Endothelial Cell Migration and Growth Free
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Wenyi Cai; Susan L. Rook; Zhen Y. Jiang; Noriko Takahara; Lloyd Paul Aiello
Tags: 1-phosphatidylinositol 3-kinase, endothelial cells, hepatocyte growth factor, mitogen-activated protein kinases, phosphorylation
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1885-1893. doi:
A Frequent 1085delC/insGAAG Mutation in the RDH5 Gene in Japanese Patients with Fundus Albipunctatus Free
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Yuko Wada; Toshiaki Abe; Nobuo Fuse; Makoto Tamai
Tags: genes, japanese, mutation, pigmentary retinal dystrophy
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1894-1897. doi:
Disease Expression of RP1 Mutations Causing Autosomal Dominant Retinitis Pigmentosa Free
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Samuel G. Jacobson; Artur V. Cideciyan; Alessandro Iannaccone; Richard G. Weleber; Gerald A. Fishman; Albert M. Maguire; Louisa M. Affatigato; Jean Bennett; Eric A. Pierce; Michael Danciger; Debora B. Farber; Edwin M. Stone
Tags: mutation, retinitis pigmentosa, retinal cone, rod photoreceptors, phenotype
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1898-1908. doi:
Hemangioblastomas of the Retina: Impact of von Hippel–Lindau Disease Free
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Mika Niemelä; Sebsebe Lemeta; Markku Sainio; Sirpa Rauma; Eero Pukkala; Juha Kere; Tom Böhling; Leila Laatikainen; Juha Jääskeläinen; Paula Summanen
Tags: follow-up, retinal hemangioblastoma, von hippel-lindau syndrome, family, cysts
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1909-1915. doi:
Methods and Limits of Digital Image Compression of Retinal Images for Telemedicine Free
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Robert H. Eikelboom; Kanagasingam Yogesan; Chris J. Barry; Ian J. Constable; Mei–Ling Tay–Kearney; Ludmila Jitskaia; Philip H. House
Tags: compression, eye, image compression, image quality, telemedicine
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1916-1924. doi:
Significant Reduction of the Panretinal Oxygenation Response after 28% Supplemental Oxygen Recovery in Experimental ROP Free
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Bruce A. Berkowitz; Wei Zhang
Tags: alveolar ventilation function, cell respiration, magnetic resonance imaging, oxygen, recovery of function
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1925-1931. doi:

Retinal Cell Biology

An Abnormal Response of Retinoblastoma Cells (Y-79) to Neurotrophins Free
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Nicole Wagner; Kay D. Wagner; Mark Sefton; Alfredo Rodríguez–Tébar; Rosemarie Grantyn
Tags: nerve growth factors, retinoblastoma
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1932-1939. doi:
Concurrent Downregulation of a Glutamate Transporter and Receptor in Glaucoma Free
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Rita Naskar; Christian K. Vorwerk; Evan B. Dreyer
Tags: down-regulation, glaucoma, glutamate, glutamates, membrane transport proteins
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1940-1944. doi:
High Levels of E-/P-Cadherin: Correlation with Decreased Apical Polarity of Na/K ATPase in Bovine RPE Cells In Situ Free
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Janice M. Burke; Feng Cao; Pamela E. Irving
Tags: cadherins, cattle, na(+)-k(+)-exchanging atpase, retinal pigment cell, ankyrins
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1945-1952. doi:
Synergistic Effect of Bcl-2 and BAG-1 on the Prevention of Photoreceptor Cell Death Free
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Pamela Eversole–Cire; Francis A. Concepcion; Melvin I. Simon; Shinichi Takayama; John C. Reed; Jeannie Chen
Tags: bcl2 gene, photoreceptors, prevention, animals, transgenic, retina
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1953-1961. doi:
Adrenomedullin in Cultured Human Retinal Pigment Epithelial Cells Free
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Tetsuo Udono; Kazuhiro Takahashi; Masaharu Nakayama; Osamu Murakami; Yusuf K. Durlu; Makoto Tamai; Shigeki Shibahara
Tags: adrenomedullin, retinal pigment cell, cytokine, rna, messenger, peptides
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1962-1970. doi:
Glial Reactivity, an Early Feature of Diabetic Retinopathy Free
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Elisabeth Rungger–Brändle; André A. Dosso; Peter M. Leuenberger
Tags: astrocytes, diabetes mellitus, diabetic retinopathy, glial fibrillary acidic protein, microglia
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1971-1980. doi:
The Lipofuscin Fluorophore A2E Mediates Blue Light–Induced Damage to Retinal Pigmented Epithelial Cells Free
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Janet R. Sparrow; Koji Nakanishi; Craig A. Parish
Tags: blue light, epithelial cells, lipofuscin, retinal pigment cell, cell nucleus
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1981-1989. doi:
Spatiotemporal Expression Patterns of 6B4 Proteoglycan/Phosphacan in the Developing Rat Retina Free
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Masaru Inatani; Hidenobu Tanihara; Atsuhiko Oohira; Megumi Honjo; Noriaki Kido; Yoshihito Honda
Tags: proteoglycan, retina, immunoblotting
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1990-1997. doi:

Visual Neuroscience

Functional Assessment of the Regional Distribution of Disease in a Cat Model of Hereditary Retinal Degeneration Free
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Mathias W. Seeliger; Kristina Narfström
Tags: adaptive testing, cats, lasers, retinal degeneration, electroretinography
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1998-2005. doi:

Visual Psychophysics and Physiological Optics

Effect of Instructions on Conventional Automated Perimetry Free
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Kim E. Kutzko; Caridad F. Brito; Michael Wall
Tags: perimetry, questionnaires, teaching
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 2006-2013. doi:

New Developments in Vision Research

Recent Developments in Circadian Photoreception: More Than Meets the Eye Free
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Malcolm von Schantz; Ignacio Provencio; Russell G. Foster
Tags: eye, mammals
Investigative Ophthalmology & Visual Science June 2000, Vol.41, 1605-1607. doi:

In-Brief

Specialized Proteins and Specialized Functions in Ocular Tissues Free
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Tags: body tissue, proteins, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science June 2000, Vol.41, f4-F5. doi:
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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