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Editorial

What IOVS Authors Should Know Free
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Tags: color, eye, helsinki declaration, science, vision
Investigative Ophthalmology & Visual Science July 2000, Vol.41, i-vi. doi:

Anatomy and Pathology/Oncology

Cone Properties of Retinal Margin Cells in the Monkey (Macaca mulatta) Free
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Xiaoming Chen; Kenneth C. Wikler; Peter R. MacLeish
Tags: antibodies, cercopithecidae, macaca mulatta, retinal cone
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2019-2022. doi:
Expression of Epidermal Growth Factor Receptor: Risk Factor in Uveal Melanoma Free
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H. Monique H. Hurks; Jessica A. W. Metzelaar-Blok; Ed R. Barthen; Aeilko H. Zwinderman; Didi De Wolff-Rouendaal; Jan E. E. Keunen; Martine J. Jager
Tags: epidermal growth factor receptors, uveal melanoma, risk factors, neoplasms, histopathology tests
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2023-2027. doi:
Induced Myopia Associated with Increased Scleral Creep in Chick and Tree Shrew Eyes Free
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John R. Phillips; Mohammad Khalaj; Neville A. McBrien
Tags: eye, myopia, sclera, tupaiidae
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2028-2034. doi:
Ultrastructural Changes in Bruch’s Membrane of Apolipoprotein E–Deficient Mice Free
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Stefan Dithmar; Christine A. Curcio; Ngoc-Anh Le; Stephanie Brown; Hans E. Grossniklaus
Tags: apolipoprotein e, bruch's basal membrane, mice
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2035-2042. doi:
Form Deprivation Myopia in Mature Common Marmosets (Callithrix jacchus) Free
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David Troilo; Debora L. Nickla; Christine F. Wildsoet
Tags: callithrix, myopia, eye
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2043-2049. doi:

Biochemistry and Molecular Biology

Decreased Proteoglycan Synthesis Associated with Form Deprivation Myopia in Mature Primate Eyes Free
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Jody A. Rada; Debora L. Nickla; David Troilo
Tags: eye, myopia, proteoglycan, sclera, primates
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2050-2058. doi:
Isolation of a Novel Iris-Specific and Leucine-Rich Repeat Protein (Oculoglycan) Using Differential Selection Free
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James S. Friedman; Ron Ducharme; Vincent Raymond; Michael A. Walter
Tags: dna, complementary, immune reconstitution inflammatory syndrome, iris, leucine, patient isolation
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2059-2066. doi:
UV Absorption by Uric Acid in Diurnal Bird Aqueous Humor Free
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Amund Ringvold; Erlend Anderssen; Inge Kjønniksen
Tags: aqueous humor, aves, process of absorption, ultraviolet rays, uric acid
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2067-2069. doi:
Molecular Cloning of the Bovine MYOC and Induction of Its Expression in Trabecular Meshwork Cells Free
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Fumiko Taniguchi; Yasuyuki Suzuki; Hiroki Kurihara; Yukiko Kurihara; Hiroyoshi Kasai; Shiroaki Shirato; Makoto Araie
Tags: cattle, myoc gene, trabecular meshwork, molecular cloning, rna, messenger
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2070-2075. doi:
A CRX Null Mutation Is Associated with Both Leber Congenital Amaurosis and a Normal Ocular Phenotype Free
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Eduardo Silva; Jun-Ming Yang; Yingying Li; Sharola Dharmaraj; Olof H. Sundin; Irene H. Maumenee
Tags: leber's amaurosis, mutation, phenotype
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2076-2079. doi:
Evidence for a New Locus for X-Linked Retinitis Pigmentosa (RP23) Free
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Alison J. Hardcastle; Dawn L. Thiselton; Ilaria Zito; Neil Ebenezer; Tammy S. Mah; Michael B. Gorin; Shomi S. Bhattacharya
Tags: family, genetic linkage analysis, haplotypes, retinitis pigmentosa, x-linked inheritance
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2080-2086. doi:
Retinal Fascin: Functional Nature, Subcellular Distribution, and Chromosomal Localization Free
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Yoshitsugu Saishin; Ryoki Ishikawa; Shinya Ugawa; Wei Guo; Takashi Ueda; Hiroyuki Morimura; Kazuhiro Kohama; Hideo Shimizu; Yasuo Tano; Shoichi Shimada
Tags: actins, chromosomes, dna, complementary, proteins, immunohistochemistry
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2087-2095. doi:

Clinical and Epidemiologic Research

PCR Assessment of HSV-1 Corneal Infection in Animals Treated with Rose Bengal and Lissamine Green B Free
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William G. Stroop; Tsuey Ming Chen; James Chodosh; Thomas E. Kienzle; Janice L. Stroop; Jeng-Yang Ling; Dorothy A. Miles
Tags: corneal infections, eye, human herpesvirus 1, polymerase chain reaction, rose bengal
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2096-2102. doi:
Age-Related Decreases in the Prevalence of Myopia: Longitudinal Change or Cohort Effect? Free
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Donald O. Mutti; Karla Zadnik
Tags: cohort effect, myopia, prevalence, national health and nutrition examination survey
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2103-2107. doi:
Congenital and Infantile Cataract in the United Kingdom: Underlying or Associated Factors Free
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Jugnoo S. Rahi; Carol Dezateux; the British Congenital Cataract Interest Group
Tags: cataract
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2108-2114. doi:
Plasma VEGF and Soluble VEGF Receptor FLT-1 in Proliferative Retinopathy: Relationship to Endothelial Dysfunction and Laser Treatment Free
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Peck Lin Lip; Funmi Belgore; Andrew D. Blann; Monique W. Hope-Ross; Jonathan M. Gibson; Gregory Y. H. Lip
Tags: diabetic retinopathy, endothelial dysfunction, laser therapy, plasma, proliferative diabetic retinopathy
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2115-2119. doi:

Cornea

Autosomal Recessive Cornea Plana: In Vivo Corneal Morphology and Corneal Sensitivity Free
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Minna H. Vesaluoma; Eeva–Marja Sankila; Juana Gallar; Linda J. Müller; W. Matthew Petroll; Jukka A. O. Moilanen; Henrik Forsius; Timo M. T. Tervo
Tags: autosomal recessive inheritance, cornea, language morphology, morphology, sensory perception
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2120-2126. doi:
Development of Conjunctival Goblet Cells and Their Neuroreceptor Subtype Expression Free
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José D. Ríos; Keisha Forde; Yolanda Diebold; Jessica Lightman; James D. Zieske; Darlene A. Dartt
Tags: conjunctiva, goblet cells, receptors, sensory
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2127-2137. doi:
Effects of Oleoresin Capsicum Pepper Spray on Human Corneal Morphology and Sensitivity Free
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Minna Vesaluoma; Linda Müller; Juana Gallar; Alessandro Lambiase; Jukka Moilanen; Tapani Hack; Carlos Belmonte; Timo Tervo
Tags: cornea, language morphology, morphology, oleoresin capsicum, eye
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2138-2147. doi:
Fine Needle Diathermy Occlusion of Corneal Vessels Free
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Chidambara T. Pillai; Harminder S. Dua; Parwez Hossain
Tags: cornea, diathermy, needles, corneal neovascularization, lipids
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2148-2153. doi:
Regulation of Collagenase, Stromelysin, and Urokinase-Type Plasminogen Activator in Primary Pterygium Body Fibroblasts by Inflammatory Cytokines Free
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Abraham Solomon; De-Quan Li; Sao-Bing Lee; Scheffer C. G. Tseng
Tags: cytokine, fibroblasts, interstitial collagenase, proteins, pterygium
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2154-2163. doi:
Inhibitory Effect of PGE2 on EGF-Induced MAP Kinase Activity and Rabbit Corneal Epithelial Proliferation Free
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Sylvia S. Kang; Tie Li; Dazhong Xu; Peter S. Reinach; Luo Lu
Tags: cornea, epithelium, mitogen-activated protein kinases, oryctolagus cuniculus, phosphotransferases
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2164-2169. doi:
The Effect of Hypoxia on Endogenous Corneal Epithelial Eicosanoids Free
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Paul A. Mieyal; Albino Bonazzi; Houli Jiang; Michael W. Dunn; Michal Laniado Schwartzman
Tags: 12-hydroxy-5,8,10,14-eicosatetraenoic acid, cornea, eicosanoids, epithelium, hypoxia
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2170-2176. doi:

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Eye Movements in Parkinson’s Disease: Before and After Pallidotomy Free
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Tanya Blekher; Eric Siemers; Larry A. Abel; Robert D. Yee
Tags: eye movement, pallidotomy, parkinson disease, saccades
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2177-2183. doi:

Glaucoma

Efferent and Afferent Innervation of Primate Trabecular Meshwork and Scleral Spur Free
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J. Michael Selbach; Johannes Gottanka; Markus Wittmann; Elke Lütjen–Drecoll
Tags: calcitonin gene-related peptide, cercopithecidae, eye, nerve supply, neuropeptide y
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2184-2191. doi:
Simulation of Longitudinal Threshold Visual Field Data Free
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Paul G. D. Spry; Alex B. Bates; Chris A. Johnson; Balwantray C. Chauhan
Tags: visual fields, glaucoma, glaucomatous visual field defect, linear regression
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2192-2200. doi:
False-Negative Responses in Glaucoma Perimetry: Indicators of Patient Performance or Test Reliability? Free
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Boel Bengtsson; Anders Heijl
Tags: false-negative results, glaucoma, perimetry, reliability, test, eye
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2201-2204. doi:
Photopic Negative Response of the Human ERG: Losses Associated with Glaucomatous Damage Free
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Alberto Colotto; Benedetto Falsini; Tommaso Salgarello; Giancarlo Iarossi; Maria Elena Galan; Luigi Scullica
Tags: electroretinography, erg protein, human, glaucoma
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2205-2211. doi:
Predicting Binocular Visual Field Sensitivity from Monocular Visual Field Results Free
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Jacqueline M. Nelson-Quigg; Kimberly Cello; Chris A. Johnson
Tags: visual fields, eye, summation
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2212-2221. doi:
Regulation of Connexin Phosphorylation and Cell–Cell Coupling in Trabecular Meshwork Cells Free
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Shinji Kimura; Katsuyoshi Suzuki; Takeshi Sagara; Teruo Nishida; Tetsuya Yamamoto; Yoshiaki Kitazawa
Tags: cattle, connexin 43, dyes, gap junction protein, immunoblotting
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2222-2228. doi:
Induction of Tissue Transglutaminase in the Trabecular Meshwork by TGF-β1 and TGF-β2 Free
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Ulrich Welge-Lüßen; Chr. Albrecht May; Elke Lütjen-Drecoll
Tags: body tissue, fibronectins, transglutaminases, western blotting, trabecular meshwork
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2229-2238. doi:

Immunology and Microbiology

Effect of Macrophage Depletion on Immune Effector Mechanisms during Corneal Allograft Rejection in Rats Free
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Tanja P. A. M. Slegers; Paulo F. Torres; Lidy Broersma; Nico van Rooijen; Gabriel van Rij; Ruth van der Gaag
Tags: allografting, antigens, clodronate, cornea, did not receive therapy or drug
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2239-2247. doi:
Murine Cytomegalovirus Infection Causes Apoptosis of Uninfected Retinal Cells Free
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John E. Bigger; Minoru Tanigawa; Ming Zhang; Sally S. Atherton
Tags: apoptosis, cytomegalovirus infections, mice, t-lymphocytes, infections
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2248-2254. doi:

Lens

A Human Lens Model of Cortical Cataract: Ca2+-Induced Protein Loss, Vimentin Cleavage and Opacification Free
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Julie Sanderson; Julia M. Marcantonio; George Duncan
Tags: cortical cataract, lens (device), lens, crystalline, opacification, proteins
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2255-2261. doi:
Polymorphic Glutathione S-Transferases as Genetic Risk Factors for Senile Cortical Cataract in Estonians Free
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Erkki Juronen; Gunnar Tasa; Siiri Veromann; Lii Parts; Anne Tiidla; Riina Pulges; Aleksei Panov; Leili Soovere; Külle Koka; Aavo-Valdur Mikelsaar
Tags: cataract, cortical cataract, genetic risk, glutathione, transferase
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2262-2267. doi:

Physiology and Pharmacology

Effect of Brimonidine on Rabbit Trabecular Meshwork Hyaluronidase Activity Free
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Jorge Benozzi; Carolina O. Jaliffa; Francisco Firpo Lacoste; Diego Weinberg Llomovatte; María I. Keller Sarmiento; Ruth E. Rosenstein
Tags: brimonidine, hyaluronidase, oryctolagus cuniculus, trabecular meshwork, cyclic amp
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2268-2272. doi:
Protective Effect of Bradykinin against Glutamate Neurotoxicity in Cultured Rat Retinal Neurons Free
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Hiroki Yasuyoshi; Satoshi Kashii; Shen Zhang; Akihiro Nishida; Tomofusa Yamauchi; Yoshihito Honda; Yukiyasu Asano; Sachi Sato; Akinori Akaike
Tags: bradykinin, glutamate, glutamates, neurons, neurotoxicity syndromes
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2273-2278. doi:
Transient Ca2+-Activated Cl− Currents with Endothelin in Isolated Arteriolar Smooth Muscle Cells of the Choroid Free
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Tim M. Curtis; C. Norman Scholfield
Tags: choroid, endothelin-1, endothelins, myocytes, smooth muscle, voltage
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2279-2285. doi:

Retina

Computer-Assisted Quantitation of Choroidal Neovascularization for Clinical Trials Free
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Jeffrey W. Berger; Jonathan Yoken
Tags: choroidal neovascularization, computers
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2286-2295. doi:
Plasminogen Activator Inhibitor (PAI)-1 Overexpression in Retinal Microvessels of PAI-1 Transgenic Mice Free
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Maria B. Grant; Polyxenie E. Spoerri; Denifield W. Player; David M. Bush; E. Ann Ellis; Sergio Caballero; W. Gerald Robison
Tags: mice, transgenic, plasminogen activator inhibitor, plasminogen activator inhibitor 1, protein overexpression, microvessels
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2296-2302. doi:
Photodamage to Human RPE Cells by A2-E, a Retinoid Component of Lipofuscin Free
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Florian Schütt; Sallyanne Davies; Jürgen Kopitz; Frank G. Holz; Michael E. Boulton
Tags: lipofuscin, photodamaged skin, retinal pigment cell, retinoids
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2303-2308. doi:
Peroxisome Proliferator-Activated Receptor-γ Ligands Inhibit Choroidal Neovascularization Free
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Toshinori Murata; Shikun He; Masanori Hangai; Tatsuro Ishibashi; Xiao-Ping Xi; Sarah Kim; Willa A. Hsueh; Stephen J. Ryan; Ronald E. Law; David R. Hinton
Tags: choroidal neovascularization, chronic exertional compartment syndrome, ligands, peroxisome proliferator-activated receptors, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2309-2317. doi:
Photoreceptor Degeneration in the RCS Rat Attenuates Dendritic Transport and Axonal Regeneration of Ganglion Cells Free
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Mitrofanis Pavlidis; Dietmar Fischer; Solon Thanos
Tags: axon, biological transport, dendrites, ganglia, photoreceptors
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2318-2328. doi:
Somatostatin Receptor 2A Expression in Choroidal Neovascularization Secondary to Age-Related Macular Degeneration Free
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Antoinette C. Lambooij; Robert W. A. M. Kuijpers; Elgin G. R. van Lichtenauer–Kaligis; Mike Kliffen; G. Seerp Baarsma; P. Martin van Hagen; Cornelia M. Mooy
Tags: age-related macular degeneration, choroidal neovascularization, somatostatin receptor, reverse transcriptase polymerase chain reaction, somatostatin
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2329-2335. doi:
TGF-β1, TGF-β Receptor II and ED-A Fibronectin Expression in Myofibroblast of Vitreoretinopathy Free
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Marie-Luce Bochaton-Piallat; Anastasios D. Kapetanios; Guy Donati; Mireille Redard; Giulio Gabbiani; Constantin J. Pournaras
Tags: actins, fibronectins, myofibroblasts, antibodies, immunohistochemistry
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2336-2342. doi:

Retinal Cell Biology

Iron, Ferritin, Transferrin, and Transferrin Receptor in the Adult Rat Retina Free
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Marina G. Yefimova; Jean-Claude Jeanny; Xavier Guillonneau; Nicole Keller; Jeanine Nguyen–Legros; Claire Sergeant; Florian Guillou; Yves Courtois
Tags: adult, ferritin, iron, retina, transferrin
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2343-2351. doi:
Localization of Tubby-like Protein 1 in Developing and Adult Human Retinas Free
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Ann H. Milam; Anita E. Hendrickson; Ming Xiao; Julie E. Smith; Daniel E. Possin; Sinoj K. John; Patsy M. Nishina
Tags: adult, proteins, retina
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2352-2356. doi:
Expression and Splicing of FGF Receptor mRNAs during ARPE-19 Cell Differentiation In Vitro Free
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Mitra Alizadeh; Claire M. Gelfman; Shellie R. Bench; Leonard M. Hjelmeland
Tags: cell differentiation, fibroblast growth factor receptors, protein isoforms, rna splicing, rna, messenger
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2357-2362. doi:
Expression of Integrin α5β1 and MMPs Associated with Epithelioid Morphology and Malignancy of Uveal Melanoma Free
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Alain Béliveau; Mélanie Bérubé; Alain Rousseau; Guy Pelletier; Sylvain L. Guérin
Tags: cell lines, integrins, matrix metalloproteinases, uveal melanoma, cancer
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2363-2372. doi:
Effects of Brain-Derived Neurotrophic Factor and Neurotrophin-4 on Isolated Cultured Retinal Ganglion Cells: Evaluation by Flow Cytometry Free
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Fumiko Kashiwagi; Kenji Kashiwagi; Yoko Iizuka; Shigeo Tsukahara
Tags: brain-derived neurotrophic factor, flow cytometry, ntf5 gene, retinal ganglion cells
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2373-2377. doi:
Inhibition of Retinal Angiogenesis by Peptides Derived from Thrombospondin-1 Free
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Afshin Shafiee; John S. Penn; Henry C. Krutzsch; John K. Inman; David D. Roberts; Diane A. Blake
Tags: angiogenesis, peptides, thrombospondin 1
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2378-2388. doi:
Selective Killing of RPE with a Vascular Endothelial Growth Factor Chimeric Toxin Free
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Stephan Hoffmann; Rizwan Masood; Ya Zhang; Shikun He; Stephen J. Ryan; Parkash Gill; David R. Hinton
Tags: retinal pigment cell, toxins, vascular endothelial growth factor a, killing, chimera organism
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2389-2393. doi:

New Developments in Vision Research

Spare the Rods, Save the Cones in Aging and Age-related Maculopathy Free
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Christine A. Curcio; Cynthia Owsley; Gregory R. Jackson
Tags: age-related macular degeneration, aging, retinal cone, rod photoreceptors
Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2015-2018. doi:

Erratum

Erratum Free
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Investigative Ophthalmology & Visual Science July 2000, Vol.41, 2027. doi:

In-Brief

Growth Factors, Receptors, and Extracellular Matrix Molecules: Key Factors in Controlling Normal and Abnormal Growth of Ocular Tissues Free
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Tags: body tissue, choroidal neovascularization, extracellular matrix, growth factor receptors, molecule
Investigative Ophthalmology & Visual Science July 2000, Vol.41, f4-f5. doi:
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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