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Anatomy and Pathology/Oncology

Astrocytes and Blood Vessels Define the Foveal Rim during Primate Retinal Development Free
PDF
Jan M. Provis; Trent Sandercoe; Anita E. Hendrickson
Tags: astrocytes, blood capillaries, fovea centralis, primates, retina
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 2827-2836. doi:
Cyclin-Dependent Kinase Inhibitory Protein Expression in Human Choroidal Melanoma Tumors Free
PDF
Frédéric Mouriaux; Claude-Alain Maurage; Pierre Labalette; Bernard Sablonnière; François Malecaze; Jean-Marie Darbon
Tags: cyclin-dependent kinases, malignant melanoma of choroid, neoplasms, proteins, ki-67 antigen
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 2837-2843. doi:
Evaluation of Leukocyte Dynamics in Choroidal Circulation with Indocyanine Green–Stained Leukocytes Free
PDF
Ippei Takasu; Fumio Shiraga; Toshio Okanouchi; Yozo Tsuchida; Hiroshi Ohtsuki
Tags: choroidal circulation, indocyanine green, leukocytes, cercopithecidae, oryctolagus cuniculus
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 2844-2848. doi:

Biochemistry and Molecular Biology

Nuclear Trafficking of Photoreceptor Protein Crx: The Targeting Sequence and Pathologic Implications Free
PDF
Yijian Fei; Thomas E. Hughes
Tags: proteins, fusion proteins, photoreceptors
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 2849-2856. doi:
Heat Shock Cognate-70 Gene Expression Declines during Normal Aging of the Primate Retina Free
PDF
Steven L. Bernstein; Anna M.-H. Liu; Barbara C. Hansen; Richard Idem Somiari
Tags: aging, gene expression, heat-shock response, primates, retina
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 2857-2862. doi:
Ribozyme-Based Therapeutic Approaches for Autosomal Dominant Retinitis Pigmentosa Free
PDF
Brian O’Neill; Sophia Millington–Ward; Mary O’Reilly; Gearóid Tuohy; Anna–Sophia Kiang; Paul F. Kenna; Peter Humphries; G. Jane Farrar
Tags: catalytic rna, retinitis pigmentosa, cytokinesis, kinetics
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 2863-2869. doi:

Clinical and Epidemiologic Research

Component Perimetry: A Fast Method to Detect Visual Field Defects Caused by Brain Lesions Free
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Gudrun Bachmann; Manfred Fahle
Tags: perimetry, scotoma, visual field defects, visual fields
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 2870-2886. doi:

Cornea

Apoptosis in the Endothelium of Human Corneas for Transplantation Free
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Julie Albon; Andrew B. Tullo; Saeed Aktar; Michael E. Boulton
Tags: apoptosis, cornea, endothelium, in situ nick-end labeling, organ culture techniques
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 2887-2893. doi:
Differential Expression of MT1-MMP (MMP-14) and Collagenase III (MMP-13) Genes in Normal and Wounded Rat Corneas Free
PDF
Hongqing Q. Ye; Masaharu Maeda; Fu–Shin X. Yu; Dimitri T. Azar
Tags: collagenase, cornea, genes, polymerase chain reaction, in situ hybridization
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 2894-2899. doi:
Human Uroplakin Ib in Ocular Surface Epithelium Free
PDF
Wakako Adachi; Kousaku Okubo; Shigeru Kinoshita
Tags: dna, complementary, epithelium, proteins, corneal epithelium, fluorescent antibody technique
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 2900-2905. doi:
Modulation of Acute Inflammation and Keratocyte Death by Suturing, Blood, and Amniotic Membrane in PRK Free
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Woo Chan Park; Scheffer C. G. Tseng
Tags: amnion, in situ nick-end labeling, inflammation, acute, keratocytes, sutures
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 2906-2914. doi:
Corneal Structure and Sensitivity in Type 1 Diabetes Mellitus Free
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Maria E. Rosenberg; Timo M. T. Tervo; Ilkka J. Immonen; Linda J. Müller; Carola Grönhagen–Riska; Minna H. Vesaluoma
Tags: cornea, diabetes mellitus, diabetes mellitus, type 1, neuropathy, diabetes mellitus, type 2
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 2915-2921. doi:
Regulation of Collagenase, Stromelysin, and Gelatinase B in Human Conjunctival and Conjunctivochalasis Fibroblasts by Interleukin-1β and Tumor Necrosis Factor-α Free
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Daniel Meller; De–Quan Li; Scheffer C. G. Tseng
Tags: conjunctiva, conjunctivochalasis, fibroblasts, gelatinase b, interleukins
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 2922-2929. doi:
EDTA: A Promoter of Proliferation in Human Corneal Endothelium Free
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Tadashi Senoo; Yoshitaka Obara; Nancy C. Joyce
Tags: cornea, corneal endothelium, edetate disodium, edetic acid, ki-67 antigen
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 2930-2935. doi:
Molecular Cloning and Expression of an Inwardly Rectifying K+ Channel from Bovine Corneal Endothelial Cells Free
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Dongli Yang; Fang Sun; Lorie L. Thomas; James Offord; Donald K. MacCallum; David C. Dawson; Bret A. Hughes; Stephen A. Ernst
Tags: cattle, cornea, endothelial cells, molecular cloning, oocytes
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 2936-2944. doi:
On-Line 3-Dimensional Confocal Imaging In Vivo Free
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Jie Li; James V. Jester; H. Dwight Cavanagh; Truman D. Black; W. Matthew Petroll
Tags: cornea, diagnostic imaging, reconstructive surgical procedures, software, lens (device)
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 2945-2953. doi:

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Effects of a Fixation Target on Torsional Optokinetic Nystagmus Free
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Yasuo Suzuki; Yasuhiro Shinmei; Hiroyuki Nara; Tohru Ifukube
Tags: eye, nystagmus, optokinetic, velocity, calibration
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 2954-2959. doi:
Ultrasonographic Evaluation of Optic Disc Swelling: Comparison with CSLO in Idiopathic Intracranial Hypertension Free
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Ciro Tamburrelli; Tommaso Salgarello; Carmela Grazia Caputo; Andrea Giudiceandrea; Luigi Scullica
Tags: cupping therapy, papilledema, pseudotumor cerebri, ultrasonography, edema
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 2960-2966. doi:

Glaucoma

The Combined Effect of Brain-Derived Neurotrophic Factor and a Free Radical Scavenger in Experimental Glaucoma Free
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Mei–Lan Ko; Dan–Ning Hu; Robert Ritch; Sansar C. Sharma
Tags: brain-derived neurotrophic factor, free radical scavengers, glaucoma, intraocular pressure, eye
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 2967-2971. doi:
Influence of Experimental Chronic High-Pressure Glaucoma on Age-Related Macular Degeneration in Rhesus Monkeys Free
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Jost B. Jonas; Sohan Singh Hayreh
Tags: age-related macular degeneration, glaucoma, macaca mulatta, drusen
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 2972-2977. doi:
Ophthalmoscopic Appearance of the Normal Optic Nerve Head in Rhesus Monkeys Free
PDF
Jost B. Jonas; Sohan Singh Hayreh
Tags: macaca mulatta, ophthalmoscopy, optic disk, retinal nerve fiber layer, neuroretinal rim
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 2978-2983. doi:
Giant Vacuoles Are Found Preferentially near Collector Channels Free
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Christine E. Parc; Douglas H. Johnson; Harilaos S. Brilakis
Tags: vacuole
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 2984-2990. doi:
The Optic Nerve Head as a Biomechanical Structure: Initial Finite Element Modeling Free
PDF
Anthony J. Bellezza; Richard T. Hart; Claude F. Burgoyne
Tags: intraocular pressure, optic disk, sclera, stress
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 2991-3000. doi:

Immunology and Microbiology

Analysis of the Cellular Infiltrate in the Iris during Experimental Autoimmune Encephalomyelitis Free
PDF
Alex F. de Vos; Andrew D. Dick; Jan Klooster; Lidy Broersma; Paul G. McMenamin; Aize Kijlstra
Tags: experimental autoimmune encephalomyelitis, immune reconstitution inflammatory syndrome, iris, infiltrates, immunization
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3001-3010. doi:
The Role of Apoptosis within the Retina of Coronavirus-Infected Mice Free
PDF
Yun Wang; Barbara Detrick; Zu-Xi Yu; Jun Zhang; Laura Chesky; John J. Hooks
Tags: apoptosis, mice, retina, viruses, coronavirus
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3011-3018. doi:
Aging and PMN Response to P. aeruginosa Infection Free
PDF
Karen A. Kernacki; Ronald P. Barrett; Sharon A. McClellan; Linda D. Hazlett
Tags: cornea, infections, mice, aging
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3019-3025. doi:
Expression of Human Beta-Defensins in Intraocular Tissues Free
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Richard John Haynes; Jane Elizabeth McElveen; Harminder Singh Dua; Patrick Jason Tighe; Janet Liversidge
Tags: beta-defensins, body tissue, cytokine, defb4 gene, defensins
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3026-3031. doi:
Immune Privilege and Immunogenicity Reside among Different Layers of the Mouse Cornea Free
PDF
Junko Hori; Nancy C. Joyce; J. Wayne Streilein
Tags: allografting, cornea, mice, tissue transplants, endothelium
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3032-3042. doi:
Optimal Methods for Preparation and Immunostaining of Iris, Ciliary Body, and Choroidal Wholemounts Free
PDF
Paul G. McMenamin
Tags: body tissue, ciliary body, immune reconstitution inflammatory syndrome, immunohistochemistry, iris
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3043-3048. doi:

Lens

Blocking Chloride Channels in the Rat Lens: Localized Changes in Tissue Hydration Support the Existence of a Circulating Chloride Flux Free
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Miriam A. Young; Mark J. Tunstall; Joerg Kistler; Paul J. Donaldson
Tags: body tissue, chloride channels, chlorides, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3049-3055. doi:
Expression of βB2-Crystallin mRNA and Protein in Retina, Brain, and Testis Free
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Kristine S. Magabo; Joseph Horwitz; Joram Piatigorsky; Marc Kantorow
Tags: brain, crystallins, proteins, retina, rna, messenger
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3056-3060. doi:
Impact of Aging and Hyperbaric Oxygen In Vivo on Guinea Pig Lens Lipids and Nuclear Light Scatter Free
PDF
Douglas Borchman; Frank J. Giblin; Victor R. Leverenz; Venkat N. Reddy; Li-Ren Lin; Marta Cecilia Yappert; Daxin Tang; Li Li
Tags: lens (device), lens, crystalline, lipids, guinea, oxidation
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3061-3073. doi:
Retroillumination versus Reflected-Light Images in the Photographic Assessment of Posterior Capsule Opacification Free
PDF
Monica Camparini; Claudio Macaluso; Luca Reggiani; Giovanni Maraini
Tags: after-cataract, slit lamps, photography
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3074-3079. doi:

Physiology and Pharmacology

Effects of Systemic NO Synthase Inhibition on Choroidal and Optic Nerve Head Blood Flow in Healthy Subjects Free
PDF
Alexandra Luksch; Kaija Polak; Carolin Beier; Elzbieta Polska; Michael Wolzt; Guido T. Dorner; Hans–Georg Eichler; Leopold Schmetterer
Tags: nitric oxide synthase, omega-n-methylarginine, optic disk, vascular flow, laser-doppler flowmetry
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3080-3084. doi:

Retina

Active Scatter Factor (HGF/SF) in Proliferative Vitreoretinal Disease Free
PDF
Michael C. Briggs; Ian Grierson; Paul Hiscott; John A. Hunt
Tags: enzyme-linked immunosorbent assay, epiretinal membrane, hepatocyte growth factor, magnetic resonance cholangiography, met gene
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3085-3094. doi:
Dexamethasone and Critical Effect of Timing on Retinopathy Free
PDF
Panitan Yossuck; Yun Yan; Misrak Tadesse; Rosemary D. Higgins
Tags: dexamethasone, retinal diseases, oxygen
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3095-3099. doi:
Human Neural Retinal Transplantation Free
PDF
Mark S. Humayun; Eugene de Juan, Jr; Manuel del Cerro; Gislin Dagnelie; Wolfgang Radner; Srinivas R. Sadda; Constancia del Cerro
Tags: transplantation, vision, electroretinography, body tissue
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3100-3106. doi:
Attenuation of Experimental Proliferative Vitreoretinopathy by Inhibiting the Platelet-Derived Growth Factor Receptor Free
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Yasushi Ikuno; Fee–Lai Leong; Andrius Kazlauskas
Tags: attenuation, phosphotransferases, platelet-derived growth factor, platelet-derived growth factor receptor, vitreoretinopathy, proliferative
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3107-3116. doi:
Metabolic Dependence of Photoreceptors on the Choroid in the Normal and Detached Retina Free
PDF
Robert A. Linsenmeier; Lissa Padnick–Silver
Tags: choroid, photoreceptors, retinal detachment, hyperoxia, retina
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3117-3123. doi:
Novel Rhodopsin Mutations Gly114Val and Gln184Pro in Dominant Retinitis Pigmentosa Free
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Thaddeus P. Dryja; Jennifer A. McEvoy; Terri L. McGee; Eliot L. Berson
Tags: mutation, retinitis pigmentosa, rhodopsin
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3124-3127. doi:
Retinal Dysfunction in Basigin Deficiency Free
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Kenji Hori; Naomi Katayama; Shu Kachi; Mineo Kondo; Kenji Kadomatsu; Jiro Usukura; Takashi Muramatsu; Shigeo Mori; Yozo Miyake
Tags: electroretinography, mice, pathophysiology, retina
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3128-3133. doi:
Local Immunosuppression Prolongs Survival of RPE Xenografts Labeled by Retroviral Gene Transfer Free
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Chi–Chun Lai; Peter Gouras; Kentaro Doi; Stephen H. Tsang; Stephen P. Goff; Paul Ashton
Tags: cyclosporine, eye, gene transfer techniques, natural immunosuppression, retroviridae
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3134-3141. doi:
Histologic Correlation of Human Neural Retinal Transplantation Free
PDF
Manuel del Cerro; Mark S. Humayun; Srinivas R. Sadda; Jingtai Cao; Nobutsugu Hayashi; W. Richard Green; Constancia del Cerro; Eugene de Juan, Jr
Tags: transplantation, fetus
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3142-3148. doi:
Retinal Degeneration 6 (rd6): A New Mouse Model for Human Retinitis Punctata Albescens Free
PDF
Norman L. Hawes; Bo Chang; Gregory S. Hageman; Steven Nusinowitz; Patsy M. Nishina; Bobbie S. Schneider; Richard S. Smith; Thomas H. Roderick; Muriel T. Davisson; John R. Heckenlively
Tags: mice, retinal degeneration, retinitis, phenotype, electroretinography
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3149-3157. doi:

Retinal Cell Biology

VEGF Is Major Stimulator in Model of Choroidal Neovascularization Free
PDF
Nohoon Kwak; Naoyuki Okamoto; Jeanette M. Wood; Peter A. Campochiaro
Tags: choroidal neovascularization, copy number polymorphism, vascular endothelial growth factor a, kinase inhibitors, mice
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3158-3164. doi:
Axonal Regeneration of Retinal Ganglion Cells Depending on the Distance of Axotomy in Adult Hamsters Free
PDF
Si–Wei You; Kwok–Fai So; Henry K. Yip
Tags: adult, axotomy, cricetinae, retinal ganglion cells, tissue transplants
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3165-3170. doi:
Cone Differentiation with No Photopigment Coexpression Free
PDF
Zsuzsanna Szepessy; Ákos Lukáts; Tibor Fekete; Árpád Barsi; Pál Röhlich; Ágoston Szél
Tags: retinal cone, retina
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3171-3175. doi:
Differential Susceptibility of Retinal Ganglion Cells to Reactive Oxygen Species Free
PDF
Kim Kortuem; Lynette K. Geiger; Leonard A. Levin
Tags: catalase, disease susceptibility, oxidative stress, peroxidase, peroxides
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3176-3182. doi:
Energy Metabolism in Human Retinal Müller Cells Free
PDF
Barry S. Winkler; Matthew J. Arnold; Melissa A. Brassell; Donald G. Puro
Tags: energy metabolism, glucose, lactates, mitochondria, neuroglia
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3183-3190. doi:
Expression of Somatostatin Subtype 1 Receptor in the Rabbit Retina Free
PDF
Rosella Cristiani; Gigliola Fontanesi; Giovanni Casini; Cristina Petrucci; Cecile Viollet; Paola Bagnoli
Tags: oryctolagus cuniculus, retina, somatostatin, reverse transcriptase polymerase chain reaction, amacrine cells
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3191-3199. doi:
P23H Rhodopsin Transgenic Rat: Correlation of Retinal Function with Histopathology Free
PDF
Shigeki Machida; Mineo Kondo; Jeffrey A. Jamison; Naheed W. Khan; Laureen T. Kononen; Takeshi Sugawara; Ronald A. Bush; Paul A. Sieving
Tags: animals, transgenic, electroretinography, erg protein, human, histopathology tests, rats
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3200-3209. doi:
Post-Treatment at 12 or 18 Hours with 3-Aminobenzamide Ameliorates Retinal Ischemia–Reperfusion Damage Free
PDF
Samuel K. S. Chiang; Tim T. Lam
Tags: poly(adp-ribose) polymerases, reperfusion injury, retinal ischemia, reperfusion therapy, physiologic reperfusion
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3210-3214. doi:
Time at Confluence for Human RPE Cells: Effects on the Adherens Junction and In Vitro Wound Closure Free
PDF
Mayumi Kaida; Feng Cao; Christine M. B. Skumatz; Pamela E. Irving; Janice M. Burke
Tags: actins, adherens junction, antibodies, cadherins, calcium
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3215-3224. doi:

Visual Neuroscience

Large Phase Differences between L-Cone– and M-Cone–Driven Electroretinograms in Retinitis Pigmentosa Free
PDF
Hendrik P. N. Scholl; Jan Kremers
Tags: electroretinography, retinal cone, retinitis pigmentosa
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3225-3233. doi:
Multifocal Oscillatory Potentials in Type 1 Diabetes without Retinopathy Free
PDF
Anne Kurtenbach; Hana Langrova; Eberhart Zrenner
Tags: diabetes mellitus, diabetes mellitus, type 1, eye, retinal diseases, retina
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 3234-3241. doi:

New Developments in Vision Research

Ocular Gene Therapy: Quo Vadis? Free
PDF
William W. Hauswirth; Laurent Beaufrere
Tags: gene therapy, genes, toxic effect
Investigative Ophthalmology & Visual Science September 2000, Vol.41, 2821-2826. doi:

In-Brief

Techniques, Tools, and Models in Vision Research Free
Tags: microscopy, confocal, vision research, catalytic rna, papilledema
Investigative Ophthalmology & Visual Science September 2000, Vol.41, F4-F5. doi:
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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