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Anatomy and Pathology/Oncology

Adipogenesis in Thyroid Eye Disease Free
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Michele Crisp; Kerry Jo Starkey; Carol Lane; Jack Ham; Marian Ludgate
Tags: adipocytes, graves' ophthalmopathy, thyrotropin receptor, thyrotropin, cyclic amp
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3249-3255. doi:
MRI Dynamic Color Mapping: A New Quantitative Technique for Imaging Soft Tissue Motion in the Orbit Free
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Michael D. Abràmoff; Ad P. G. Van Gils; Gerard H. Jansen; Maarten P. Mourits
Tags: color, diagnostic imaging, magnetic resonance imaging, motion, orbit
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3256-3260. doi:

Biochemistry and Molecular Biology

Expression Regulation of Hyaluronan Synthase in Corneal Endothelial Cells Free
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Tomohiko Usui; Shiro Amano; Tetsuro Oshika; Kaori Suzuki; Kazunori Miyata; Makoto Araie; Paraskevi Heldin; Hidetoshi Yamashita
Tags: cornea, dna, complementary, endothelial cells, family, hyaluronan
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3261-3267. doi:
HRG4 (UNC119) Mutation Found in Cone–Rod Dystrophy Causes Retinal Degeneration in a Transgenic Model Free
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Akira Kobayashi; Tomomi Higashide; Duco Hamasaki; Shinya Kubota; Hitoshi Sakuma; Weijun An; Takuro Fujimaki; Margaret J. McLaren; Richard G. Weleber; George Inana
Tags: animals, transgenic, electroretinography, mice, transgenic, mutation, retinal degeneration
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3268-3277. doi:
A New βA1-Crystallin Splice Junction Mutation in Autosomal Dominant Cataract Free
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J. Bronwyn Bateman; David D. Geyer; Pamela Flodman; Meriam Johannes; James Sikela; Nicole Walter; Ana Teresa Moreira; Kevin Clancy; M. Anne Spence
Tags: cataract, crystallins, mutation, family
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3278-3285. doi:
Ultrastructural and Molecular Analysis of Bowman’s Layer Corneal Dystrophies: An Epithelial Origin? Free
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Alan E. A. Ridgway; Saeed Akhtar; Francis L. Munier; Daniel F. Schorderet; Helen Stewart; Ramat Perveen; Richard E. Bonshek; Monica T. P. Odenthal; Michael Dixon; Rafael Barraquer; Remberto Escoto; Graeme C. M. Black
Tags: bowman's layer, epithelium, family, hereditary corneal dystrophy
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3286-3292. doi:
Ascorbic Acid Concentration and Total Antioxidant Activity of Human Tear Fluid Measured Using the FRASC Assay Free
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Camus Kar Man Choy; Iris Frances Forster Benzie; Pauline Cho
Tags: antioxidants, ascorbic acid, mass or substance concentration per volume, uric acid
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3293-3298. doi:
Elevated Levels of Proteolytic Enzymes in the Aging Human Vitreous Free
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Anne Vaughan–Thomas; Sophie J. Gilbert; Victor C. Duance
Tags: plasmin, vitreous body, peptide hydrolases, aging, gelatin
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3299-3304. doi:
A Novel Resource for the Study of Genes Expressed in the Adult Human Retina Free
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Stefania Bortoluzzi; Fabio d’Alessi; Gian Antonio Danieli
Tags: adult, genes, retina
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3305-3308. doi:

Clinical and Epidemiologic Research

Changing Views on Open-Angle Glaucoma: Definitions and Prevalences—The Rotterdam Study Free
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Roger C. W. Wolfs; Petra H. Borger; Raan S. Ramrattan; Caroline C. W. Klaver; Caroline A. A. Hulsman; Albert Hofman; Johannes R. Vingerling; Roger A. Hitchings; Paulus T. V. M. de Jong
Tags: eye, open-angle glaucoma, optic disk, prevalence, glaucoma
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3309-3321. doi:
Influence of Lutein Supplementation on Macular Pigment, Assessed with Two Objective Techniques Free
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Tos T. J. M. Berendschot; R. Alexandra Goldbohm; Wilhelmina A. A. Klöpping; Jan van de Kraats; Jeannette van Norel; Dirk van Norren
Tags: lutein, pigment, maps
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3322-3326. doi:
Monocular versus Binocular Visual Acuity as Measures of Vision Impairment and Predictors of Visual Disability Free
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Gary S. Rubin; Beatriz Muñoz; Karen Bandeen–Roche; Sheila K. West
Tags: disability, eye, visual acuity, visual impairment, vision
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3327-3334. doi:

Cornea

Photochemical Keratodesmos for Repair of Lamellar Corneal Incisions Free
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Louise Mulroy; June Kim; Irene Wu; Philip Scharper; Samir A. Melki; Dimitri T. Azar; Robert W. Redmond; Irene E. Kochevar
Tags: cornea, intraocular pressure, photosensitizing agents, sutures, lasers
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3335-3340. doi:
The Role of Cytotoxic T Lymphocytes in Corneal Allograft Rejection Free
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Sushma Hegde; Jerry Y. Niederkorn
Tags: allografting, cornea, perforin, rejection (psychology), t-lymphocytes, cytotoxic
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3341-3347. doi:
The Thickness of the Human Precorneal Tear Film: Evidence from Reflection Spectra Free
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P. Ewen King-Smith; Barbara A. Fink; Nick Fogt; Kelly K. Nichols; Richard M. Hill; Graeme S. Wilson
Tags: cornea, tear film finding, eye
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3348-3359. doi:
Apoptosis in Shed Human Corneal Cells Free
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Svein Estil; Earl J. Primo; Graeme Wilson
Tags: annexin a5, apoptosis, cornea, in situ nick-end labeling, acridine orange
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3360-3364. doi:
Corneal Opacity in Lumican-Null Mice: Defects in Collagen Fibril Structure and Packing in the Posterior Stroma Free
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Shukti Chakravarti; W. Matthew Petroll; John R. Hassell; James V. Jester; Jonathan H. Lass; Jennifer Paul; David E. Birk
Tags: collagen, cornea, corneal opacity, fibril, mice
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3365-3373. doi:
Erk and PI-3 Kinase Are Necessary for Collagen Binding and Actin Reorganization in Corneal Epithelia Free
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Chia Lin Chu; Wende R. Reenstra; Daniel L. Orlow; Kathy Kay Hartford Svoboda
Tags: 1-phosphatidylinositol 3-kinase, actins, collagen, corneal epithelium, mitogen-activated protein kinases
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3374-3382. doi:
Localization of Thrombomodulin in the Anterior Segment of the Human Eye Free
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Tomohiro Ikeda; Hidemi Ishii; Toshiyuki Higuchi; Keiko Sato; Yasuhito Hayashi; Kozo Ikeda; Yoshifumi Hirabayashi
Tags: eye, thrombomodulin, oryctolagus cuniculus, immunoglobulin g, cornea
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3383-3390. doi:

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

The Distribution of Myosin Heavy Chain Isoforms among Rat Extraocular Muscle Fiber Types Free
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Neal A. Rubinstein; Joseph Foon Yoong Hoh
Tags: antibodies, muscle of orbit, myosin heavy chains, protein isoforms, embryo
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3391-3398. doi:
Histologic Effect of Mitomycin C on Strabismus Surgery in the Rabbit Free
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Nilza Minguini; Keila M. Monteiro de Carvalho; Patrícia M. S. Akaishi; Iara M. S. De Luca
Tags: inflammatory response, mitomycin, oryctolagus cuniculus, strabismus, surgery specialty
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3399-3401. doi:
Acute Effects of the Skeletal Muscle-Specific Immunotoxin Ricin-mAb 35 on Extraocular Muscles of Rabbits Free
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Stephen P. Christiansen; Amy Sandnas; Robert Prill; Richard J. Youle; Linda K. McLoon
Tags: immunotoxins, monoclonal antibodies, muscle, muscle of orbit, oryctolagus cuniculus
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3402-3409. doi:
Infant Hyperacuity for Radial Deformation Free
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Eileen E. Birch; William H. Swanson; Yi-Zhong Wang
Tags: infant, adult
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3410-3414. doi:

Glaucoma

Effect of General Anesthetics on IOP in Rats with Experimental Aqueous Outflow Obstruction Free
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Lijun Jia; William O. Cepurna; Elaine C. Johnson; John C. Morrison
Tags: anesthetics, general, eye, intraocular pressure, rats, ketamine
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3415-3419. doi:
Localization of MYOC Transcripts in Human Eye and Optic Nerve by In Situ Hybridization Free
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Ruth E. Swiderski; Jean L. Ross; John H. Fingert; Abbot F. Clark; Wallace L. M. Alward; Edwin M. Stone; Val C. Sheffield
Tags: eye, in situ hybridization, myoc gene, optic nerve
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3420-3428. doi:
The Long-Term Fluctuation of the Visual Field in Stable Glaucoma Free
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Natalie Hutchings; John M. Wild; Michael K. Hussey; John G. Flanagan; Graham E. Trope
Tags: follow-up, glaucoma, visual fields, heterogeneity of variance
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3429-3436. doi:
Modulation of Pre-mRNA Splicing and Protein Production of Fibronectin by TGF-β2 in Porcine Trabecular Cells Free
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Junping Li; Brenda J. Tripathi; Ramesh C. Tripathi
Tags: fibronectins, heterogeneous nuclear rna, proteins, suidae
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3437-3443. doi:
Müller Cell Protection of Rat Retinal Ganglion Cells from Glutamate and Nitric Oxide Neurotoxicity Free
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Atsushi Kawasaki; Yasumasa Otori; Colin J. Barnstable
Tags: glutamate, glutamates, neurotoxicity syndromes, nitric oxide, retinal ganglion cells
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3444-3450. doi:
Retinal Damage after 3 to 4 Months of Elevated Intraocular Pressure in a Rat Glaucoma Model Free
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Thom W. Mittag; John Danias; Geralyn Pohorenec; Hong–Mei Yuan; Evren Burakgazi; Ruth Chalmers–Redman; Steven M. Podos; William G. Tatton
Tags: glaucoma, raised intraocular pressure, eye, retina, intraocular pressure
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3451-3459. doi:
Retrograde Axonal Transport of BDNF in Retinal Ganglion Cells Is Blocked by Acute IOP Elevation in Rats Free
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Harry A. Quigley; Stuart J. McKinnon; Donald J. Zack; Mary Ellen Pease; Lisa A. Kerrigan–Baumrind; Danielle F. Kerrigan; Rebecca S. Mitchell
Tags: axonal transport, brain-derived neurotrophic factor, eye, intraocular pressure, rats
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3460-3466. doi:

Immunology and Microbiology

Evidence that Retinal Pigment Epithelium Functions as an Immune-Privileged Tissue Free
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Hartmut Wenkel; J. Wayne Streilein
Tags: body tissue, kidney, newborn, retinal pigment cell, retinal pigment epithelium
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3467-3473. doi:
PCR-Based Evidence of Bacterial Involvement in Eyes with Suspected Intraocular Infection Free
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Narciss Okhravi; Peter Adamson; Nora Carroll; Anthony Dunlop; Melville M. Matheson; Hamish M. A. Towler; Susan Lightman
Tags: eye, eye infections, polymerase chain reaction
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3474-3479. doi:
Prospective Determination of T-Cell Responses to S-Antigen in Behçet’s Disease Patients and Controls Free
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Marc D. de Smet; Molly Dayan
Tags: antigens, behcet syndrome, t-lymphocytes, lymphocytes
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3480-3484. doi:
Role and Expression of CD40 on Human Retinal Pigment Epithelial Cells Free
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François Willermain; Laure Caspers–Velu; Nathalie Baudson; Christine Dubois; Malika Hamdane; Fabienne Willems; Thierry Velu; Catherine Bruyns
Tags: cd40 antigens, t-lymphocytes, retinal pigment cell, ligation
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3485-3491. doi:
Chronic Low Level Complement Activation within the Eye Is Controlled by Intraocular Complement Regulatory Proteins Free
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Jeong-Hyeon Sohn; Henry J. Kaplan; Hye-Jung Suk; Puran S. Bora; Nalini S. Bora
Tags: antibodies, complement activation, complement system proteins, eye, regulatory protein
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3492-3502. doi:

Lens

Differential Expression of N- and B-Cadherin during Lens Development Free
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Lilley Leong; A. Sue Menko; Gerald B. Grunwald
Tags: cadherins, lens (device), lens, crystalline, lens cell, n-cadherins
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3503-3510. doi:
A Nonsense Mutation (W9X) in CRYAA Causes Autosomal Recessive Cataract in an Inbred Jewish Persian Family Free
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Eran Pras; Moshe Frydman; Etgar Levy–Nissenbaum; Tengiz Bakhan; Judith Raz; Ehud I. Assia; Boleslaw Goldman; Elon Pras
Tags: autosomal recessive inheritance, cataract, family, judaism, mutation, nonsense
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3511-3515. doi:
Effects of Experimentally Induced Ametropia on the Morphology and Optical Quality of the Avian Crystalline Lens Free
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Sandra Priolo; Jacob G. Sivak; Jer R. Kuszak; Elizabeth L. Irving
Tags: language morphology, lens (device), lens, crystalline, morphology, optics
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3516-3522. doi:
ΔFosB-Induced Cataract Free
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Max B. Kelz; Jer R. Kuszak; Yinqing Yang; Wanchao Ma; Cathy Steffen; Kirsten Al-Ghoul; Ya-Jun Zhang; Jingshan Chen; Eric J. Nestler; Abraham Spector
Tags: cataract, lens (device), lens, crystalline, mice, proteins
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3523-3538. doi:
Influence of Exposure Time for UV Radiation–Induced Cataract Free
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Marcelo N. Ayala; Ralph Michael; Per G. Söderberg
Tags: cataract, lens (device), lens, crystalline, ultraviolet rays
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3539-3543. doi:
Susceptibility to TGFβ2-Induced Cataract Increases with Aging in the Rat Free
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Angela M. Hales; Coral G. Chamberlain; John W. McAvoy
Tags: aging, cataract, disease susceptibility, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3544-3551. doi:

Physiology and Pharmacology

Methazolamide 1% in Cyclodextrin Solution Lowers IOP in Human Ocular Hypertension Free
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Elínborg Guđmundsdóttir; Einar Stefánsson; Gyđa Bjarnadóttir; Jóhanna F. Sigurjónsdóttir; Guđrún Guđmundsdóttir; Mar Masson; Thorsteinn Loftsson
Tags: cyclodextrins, intraocular pressure, methazolamide, ocular hypertension, eyedrops
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3552-3554. doi:
A Retinal-Derived Relaxing Factor Mediates the Hypoxic Vasodilation of Retinal Arteries Free
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Christophe Delaey; Koen Boussery; Johan Van de Voorde
Tags: central retinal artery, hypoxia, body tissue, vasodilation
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3555-3560. doi:

Retina

Altered Expression of Retinal Occludin and Glial Fibrillary Acidic Protein in Experimental Diabetes Free
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Alistair J. Barber; David A. Antonetti; Thomas W. Gardner; The Penn State Retina Research Group
Tags: diabetes mellitus, glial fibrillary acidic protein, retina, streptozocin, rats
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3561-3568. doi:
Safety and Pharmacokinetics of an Intraocular Fluocinolone Acetonide Sustained Delivery Device Free
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Glenn J. Jaffe; Chang Hao Yang; Hong Guo; John P. Denny; Cristiana Lima; Paul Ashton
Tags: fluocinolone acetonide, pharmacokinetics, safety, eye
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3569-3575. doi:
Elevation of Vitreous Leptin in Diabetic Retinopathy and Retinal Detachment Free
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Ray F. Gariano; Anjali K. Nath; Donald J. D’Amico; Thomas Lee; M. Rocio Sierra–Honigmann
Tags: diabetic retinopathy, leptin, retinal detachment, vitreous body
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3576-3581. doi:

Retinal Cell Biology

Choroidal Neovascularization in the Rat Induced by Adenovirus Mediated Expression of Vascular Endothelial Growth Factor Free
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Judit Baffi; Gordon Byrnes; Chi–Chao Chan; Karl G. Csaky
Tags: adenoviruses, choroidal neovascularization, vascular endothelial growth factor a, eye
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3582-3589. doi:
Coordination between Production and Turnover of Interphotoreceptor Retinoid-Binding Protein in Zebrafish Free
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Lisa L. Cunningham; Federico Gonzalez–Fernandez
Tags: proteins, retinoids, zebrafish, eye, retina
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3590-3599. doi:
Distribution and Developmental Regulation of AMPA Receptor Subunit Proteins in Rat Retina Free
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Tatiana Gründer; Konrad Kohler; Elke Guenther
Tags: ampa receptors, proteins, regulation, retina, alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3600-3606. doi:
Lipid Peroxidation and Peroxynitrite in Retinal Ischemia–Reperfusion Injury Free
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Hiroto Shibuki; Naomichi Katai; Junji Yodoi; Koji Uchida; Nagahisa Yoshimura
Tags: lipid peroxidation, lipid peroxides, peroxynitrite, reperfusion injury, reperfusion therapy
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3607-3614. doi:
Depression of Retinal Glutamate Transporter Function Leads to Elevated Intravitreal Glutamate Levels and Ganglion Cell Death Free
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Christian K. Vorwerk; Rita Naskar; Frank Schuettauf; Kristine Quinto; David Zurakowski; Gordon Gochenauer; Michael B. Robinson; Scott A. Mackler; Evan B. Dreyer
Tags: depressive disorders, ganglia, glutamate, glutamates, membrane transport proteins
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3615-3621. doi:
Retinal Degeneration Is Slowed in Transgenic Rats by AAV-Mediated Delivery of FGF-2 Free
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Dana Lau; Laura H. McGee; Shangzhen Zhou; Katherine G. Rendahl; William C. Manning; Jaime A. Escobedo; John G. Flannery
Tags: fibroblast growth factor 2, retinal degeneration, rats, photoreceptors, retina
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3622-3633. doi:

Visual Neuroscience

Effects of Hypoxemia on the a- and b-Waves of the Electroretinogram in the Cat Retina Free
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Jennifer Kang Derwent; Robert A. Linsenmeier
Tags: adaptive testing, cats, hypoxemia, electroretinography, retina
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3634-3642. doi:
The Nature and Extent of Retinal Dysfunction Associated with Diabetic Macular Edema Free
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Vivienne C. Greenstein; Karen Holopigian; Donald C. Hood; William Seiple; Ronald E. Carr
Tags: diabetic macular edema, electroretinography, pathophysiology, visual fields
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3643-3654. doi:
Retinal Function in Diabetic Macular Edema after Focal Laser Photocoagulation Free
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Vivienne C. Greenstein; Haifan Chen; Donald C. Hood; Karen Holopigian; William Seiple; Ronald E. Carr
Tags: diabetic macular edema, electroretinography, lasers, light coagulation, visual fields
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3655-3664. doi:

Lecture

The Double-Edged Ocular Immune ResponseThe Cogan Lecture Free
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Scott M. Whitcup
Tags: immune response, uveitis, cytomegalovirus retinitis, pathogenesis, antiretroviral therapy, highly active
Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3243-3248. doi:

Erratum

Erratum Free
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Investigative Ophthalmology & Visual Science October 2000, Vol.41, 3260. doi:

In-Brief

Defining Ocular Diseases Free
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Tags: cataract, diabetic retinopathy, eye diseases, glaucoma, mutation
Investigative Ophthalmology & Visual Science October 2000, Vol.41, F4-F6. doi:
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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