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Anatomy and Pathology/Oncology

Microcirculation and Tumor-Infiltrating Macrophages in Choroidal and Ciliary Body Melanoma and Corresponding Metastases Free
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Päivi Toivonen; Teemu Mäkitie; Emma Kujala; Tero Kivelä
Tags: ciliary body melanoma, macrophages, microcirculation, neoplasm metastasis, neoplasms
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 1-6. doi:https://doi.org/10.1167/iovs.03-0622
VEGF and KDR Gene Expression during Human Embryonic and Fetal Eye Development Free
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Karïn Gogat; Laurence Le Gat; Loïc Van Den Berghe; Dominique Marchant; Alexandra Kobetz; Stéphanie Gadin; Bernard Gasser; Isabelle Quéré; Marc Abitbol; Maurice Menasche
Tags: fetus, vascular endothelial growth factor a, embryo, rna, messenger, gene expression
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 7-14. doi:https://doi.org/10.1167/iovs.02-1096

Biochemistry and Molecular Biology

Absence of Functional and Structural Abnormalities Associated with Expression of EGFP in the Retina Free
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May Nour; Alexander B. Quiambao; Muayyad R. Al-Ubaidi; Muna I. Naash
Tags: electroretinography, mice, retina, language morphology, morphology
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 15-22. doi:https://doi.org/10.1167/iovs.03-0663
Catalase and Peroxiredoxin 5 Protect Xenopus Embryos against Alcohol-Induced Ocular Anomalies Free
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Ying Peng; Pai-Hao Yang; Yan Guo; Samuel S. M. Ng; Jie Liu; P. C. W. Fung; David Tay; Jian Ge; Ming-Liang He; Hsiang-fu Kung; Marie C. Lin
Tags: catalase, embryo, ethanol, xenopus, eye
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 23-29. doi:https://doi.org/10.1167/iovs.03-0550
The Benign Concentric Annular Macular Dystrophy Locus Maps to 6p12.3-q16 Free
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Janneke J. C. van Lith-Verhoeven; Carel B. Hoyng; Bellinda van den Helm; August F. Deutman; Hendrik M. A. Brink; Martijn H. Kemperman; Wendy H. M. de Jong; Hannie Kremer; Frans P. M. Cremers
Tags: genetic linkage analysis, macular dystrophy, maps, family, mutation
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 30-35. doi:https://doi.org/10.1167/iovs.03-0392
Dominant, Gain-of-Function Mutant Produced by Truncation of RPGR Free
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Dong-Hyun Hong; Basil S. Pawlyk; Michael Adamian; Tiansen Li
Tags: antibodies, exons, fluorescent antibody technique, immunoblotting, mice
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 36-41. doi:https://doi.org/10.1167/iovs.03-0787
Transgenic Mice Expressing Cre-Recombinase Specifically in M- or S-Cone Photoreceptors Free
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Masayuki Akimoto; Elena Filippova; Philip J. Gage; Xuemei Zhu; Cheryl M. Craft; Anand Swaroop
Tags: mice, mice, transgenic, photoreceptors, retinal cone, opsin
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 42-47. doi:https://doi.org/10.1167/iovs.03-0804
Requirement of NeuroD for Photoreceptor Formation in the Chick Retina Free
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Run-Tao Yan; Shu-Zhen Wang
Tags: photoreceptors, retina, antibodies, rna, small interfering, antisense oligonucleotides
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 48-58. doi:https://doi.org/10.1167/iovs.03-0774

Clinical and Epidemiologic Research

Heritability of Risk Factors for Primary Open-Angle Glaucoma: The Beaver Dam Eye Study Free
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Barbara E. K. Klein; Ronald Klein; Kristine E. Lee
Tags: eye, open-angle glaucoma, risk factors, intraocular pressure
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 59-62. doi:https://doi.org/10.1167/iovs.03-0516
Diurnal Axial Length Fluctuations in Human Eyes Free
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Richard A. Stone; Graham E. Quinn; Ellie L. Francis; Gui-shuang Ying; D. Ian Flitcroft; Parag Parekh; Jamin Brown; Joshua Orlow; Gregor Schmid
Tags: eye, protein c inhibitor, percutaneous coronary intervention
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 63-70. doi:https://doi.org/10.1167/iovs.03-0294
Impact of Bilateral Visual Impairment on Health-Related Quality of Life: the Blue Mountains Eye Study Free
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Ee-Munn Chia; Jie Jin Wang; Elena Rochtchina; Wayne Smith; Robert R. Cumming; Paul Mitchell
Tags: eye, health-related quality of life, visual impairment
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 71-76. doi:https://doi.org/10.1167/iovs.03-0661
Importance of Vitreous Liquefaction in Age-Related Cataract Free
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George J. Harocopos; Ying-Bo Shui; Megan McKinnon; Nancy M. Holekamp; Mae O. Gordon; David C. Beebe
Tags: cataract, senile, eye, lens (device), lens, crystalline, liquefaction
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 77-85. doi:https://doi.org/10.1167/iovs.03-0820

Cornea

Evaluation for Safety of Cultured Corneal Fibroblasts with Cotreatment of Alcohol and Mitomycin C Free
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Tae-im Kim; Hungwon Tchah; Eun Hee Cho; Michael S. Kook
Tags: cornea, ethanol, fibroblasts, mitomycin, combined modality therapy
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 86-92. doi:https://doi.org/10.1167/iovs.03-0520
Sterilized, Freeze-Dried Amniotic Membrane: A Useful Substrate for Ocular Surface Reconstruction Free
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Takahiro Nakamura; Makoto Yoshitani; Helen Rigby; Nigel J. Fullwood; Wakana Ito; Tsutomu Inatomi; Chie Sotozono; Tatsuo Nakamura; Yasuhiko Shimizu; Shigeru Kinoshita
Tags: amnion, cornea, corneal epithelial cells, cryopreservation, epithelium
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 93-99. doi:https://doi.org/10.1167/iovs.03-0752
Role of p38 MAP Kinase in Regulation of Cell Migration and Proliferation in Healing Corneal Epithelium Free
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Shizuya Saika; Yuka Okada; Takeshi Miyamoto; Osamu Yamanaka; Yoshitaka Ohnishi; Akira Ooshima; Chia-Yang Liu; Daniel Weng; Winston W.-Y. Kao
Tags: antibodies, cell motility, corneal epithelium, epithelium, mitogen-activated protein kinase p38
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 100-109. doi:https://doi.org/10.1167/iovs.03-0700
Proliferative Effects of Heparin-Binding Epidermal Growth Factor–like Growth Factor on Pterygium Epithelial Cells and Fibroblasts Free
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Timothy M. Nolan; Nick Di Girolamo; Minas T. Coroneo; Denis Wakefield
Tags: epithelial cells, fibroblasts, growth factor, heparin-binding egf-like growth factor, pterygium
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 110-113. doi:https://doi.org/10.1167/iovs.03-0046
Differential Regulation of Membrane-Associated Mucins in the Human Ocular Surface Epithelium Free
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Yuichi Hori; Sandra Spurr-Michaud; Cindy Leigh Russo; Pablo Argüeso; Ilene K. Gipson
Tags: mucins, rna, messenger, tissue membrane, regulation, proteins
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 114-122. doi:https://doi.org/10.1167/iovs.03-0903

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Eye Position Specificity of Saccadic Adaptation Free
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Nadia Alahyane; Denis Pélisson
Tags: eye, saccades, specificity of diagnostic test
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 123-130. doi:https://doi.org/10.1167/iovs.03-0570
Influence of Orientation of Exiting Wire of Search Coil Annulus on Torsion after Saccades Free
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Oliver Bergamin; Stefano Ramat; Dominik Straumann; David S. Zee
Tags: eye, musculoskeletal torsion, function, saccades, torsion
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 131-137. doi:https://doi.org/10.1167/iovs.03-0615
Myosin Light Chain 1 Isoforms in Slow Fibers from Global and Orbital Layers of Canine Rectus Muscles Free
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Sabahattin Bicer; Peter J. Reiser
Tags: dog, domestic, extra-ocular rectus muscles, myosin light chains, protein isoforms, gel
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 138-143. doi:https://doi.org/10.1167/iovs.03-0716

Glaucoma

Model of Endothelin-1–Induced Chronic Optic Neuropathy in Rat Free
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Balwantray C. Chauhan; Terry L. LeVatte; Christine A. Jollimore; Paula K. Yu; Herbert A. Reitsamer; Melanie E. M. Kelly; Dao-Yi Yu; François Tremblay; Michele L. Archibald
Tags: endothelin-1, optic nerve disorders, optic disk, eye, vascular flow
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 144-152. doi:https://doi.org/10.1167/iovs.03-0687
Effects of TGF-β2 in Perfused Human Eyes Free
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Johannes Gottanka; Darren Chan; Michael Eichhorn; Elke Lütjen-Drecoll; C. Ross Ethier
Tags: eye, perfusion
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 153-158. doi:https://doi.org/10.1167/iovs.03-0796

Immunology and Microbiology

Inhibition of Endotoxin-Induced Uveitis and Potentiation of Cyclooxygenase-2 Protein Expression by α-Melanocyte–Stimulating Hormone Free
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Kenji Shiratori; Kazuhiro Ohgami; Iliyana Bozhidarova Ilieva; Yoshikazu Koyama; Kazuhiko Yoshida; Shigeaki Ohno
Tags: cyclooxygenase-2, endotoxins, hormones, mass or substance concentration per volume, melanocytes
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 159-164. doi:https://doi.org/10.1167/iovs.03-0492
Acanthamoeba Keratitis: The Role of Domestic Tap Water Contamination in the United Kingdom Free
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Simon Kilvington; Trevor Gray; John Dart; Nigel Morlet; John R. Beeching; David G. Frazer; Melville Matheson
Tags: acanthamoeba keratitis, water, water pollution, acanthamoeba, dna, mitochondrial
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 165-169. doi:https://doi.org/10.1167/iovs.03-0559
Anti-TNFα Therapy Modulates the Phenotype of Peripheral Blood CD4+ T Cells in Patients with Posterior Segment Intraocular Inflammation Free
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Kathrin Greiner; Conor C. Murphy; Francois Willermain; Linda Duncan; Jarka Plskova; Geoff Hale; John D. Isaacs; John V. Forrester; Andrew D. Dick
Tags: phenotype, t-lymphocytes, uveitis, immunoglobulins, tumor necrosis factor receptor
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 170-176. doi:https://doi.org/10.1167/iovs.03-0659
Vulnerability of Allogeneic Retinal Pigment Epithelium to Immune T-Cell–Mediated Damage In Vivo and In Vitro Free
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Parisa Zamiri; Qiang Zhang; J. Wayne Streilein
Tags: emotional vulnerability, eye, mandibulofacial dysostosis, mice, mice, inbred c57bl
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 177-184. doi:https://doi.org/10.1167/iovs.03-0211
Chemokines in Autoimmune Lacrimal Gland Disease in MRL/MpJ Mice Free
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Esen Karamursel Akpek; Douglas A. Jabs; Hervé C. Gérard; Robert A. Prendergast; Alan P. Hudson; Bella Lee; Judith A. Whittum-Hudson
Tags: autoimmune diseases, autoimmunity, chemokines, lacrimal gland, mice
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 185-190. doi:https://doi.org/10.1167/iovs.03-0812

Lens

Gap Junction Processing and Redistribution Revealed by Quantitative Optical Measurements of Connexin46 Epitopes in the Lens Free
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Marc D. Jacobs; Christian Soeller; Aran M. G. Sisley; Mark B. Cannell; Paul J. Donaldson
Tags: epitopes, gap junction protein, lens (device), lens, crystalline, optics
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 191-199. doi:https://doi.org/10.1167/iovs.03-0148
Spatial Characteristics of Receptor-Induced Calcium Signaling in Human Lens Capsular Bags Free
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David J. Collison; Lixin Wang; I. Michael Wormstone; George Duncan
Tags: acetylcholine, calcium signaling, lens, crystalline, lens (device), donors
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 200-205. doi:https://doi.org/10.1167/iovs.03-0694
Effect of Deamidation of Asparagine 146 on Functional and Structural Properties of Human Lens αB-Crystallin Free
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Ratna Gupta; Om P. Srivastava
Tags: crystallins, molecular chaperones, proteins, lens, crystalline, asparagine
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 206-214. doi:https://doi.org/10.1167/iovs.03-0720
The Effects of Phenylephrine on Pupil Diameter and Accommodation in Rhesus Monkeys Free
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Lisa A. Ostrin; Adrian Glasser
Tags: phenylephrine, visual accommodation, pupil, diameter, macaca mulatta
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 215-221. doi:https://doi.org/10.1167/iovs.03-0704
Interferon-γ Induces Apoptosis of Lens αTN4–1 Cells and Proteasome Inhibition Has an Antiapoptotic Effect Free
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Niranjan Awasthi; B. J. Wagner
Tags: antiapoptotic agents, apoptosis, human leukocyte interferon, interferons, lens (device)
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 222-229. doi:https://doi.org/10.1167/iovs.03-0571
Thioltranferase Mediated Ascorbate Recycling in Human Lens Epithelial Cells Free
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M. Rohan Fernando; Makoto Satake; Vincent M. Monnier; Marjorie F. Lou
Tags: antibodies, lens, crystalline, lysate, oxidoreductase, epithelial cells
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 230-237. doi:https://doi.org/10.1167/iovs.03-0545

Physiology and Pharmacology

Feasibility of Drug Delivery to the Posterior Pole of the Rabbit Eye with an Episcleral Implant Free
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Aki Kato; Hideya Kimura; Komei Okabe; Junko Okabe; Noriyuki Kunou; Yuichiro Ogura
Tags: implants, eye, implantation procedure, drug delivery systems, oryctolagus cuniculus
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 238-244. doi:https://doi.org/10.1167/iovs.02-1258
Purification, Molecular Cloning, and Expression of a Novel Growth-Promoting Factor for Retinal Pigment Epithelial Cells, REF-1/TFPI-2 Free
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Yasuhiko Tanaka; Jun Utsumi; Mizuo Matsui; Tetsuo Sudo; Noriko Nakamura; Masato Mutoh; Akemi Kajita; Saburo Sone; Kazuteru Kigasawa; Masahiko Shibuya; Venkat N. Reddy; Qiang Zhang; Takeshi Iwata
Tags: molecular cloning, retinal pigment cell, tissue factor pathway inhibitor
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 245-252. doi:https://doi.org/10.1167/iovs.03-0230
Myogenic Tone and Reactivity of the Rat Ophthalmic Artery Free
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Yagna P. R. Jarajapu; Maria B. Grant; Harm J. Knot
Tags: ophthalmic artery, diameter
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 253-259. doi:https://doi.org/10.1167/iovs.03-0546

Retina

Basal Laminar Deposit Formation in APO B100 Transgenic Mice: Complex Interactions between Dietary Fat, Blue Light, and Vitamin E Free
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Diego G. Espinosa-Heidmann; John Sall; Eleut P. Hernandez; Scott W. Cousins
Tags: biological response modifiers, blue light, cholesterol, diet, dietary fats
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 260-266. doi:https://doi.org/10.1167/iovs.03-0910
Transplantation of Schwann Cell Line Clones Secreting GDNF or BDNF into the Retinas of Dystrophic Royal College of Surgeons Rats Free
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Jean M. Lawrence; David J. Keegan; Elizabeth M. Muir; Peter J. Coffey; John H. Rogers; Martin J. Wilby; James W. Fawcett; Ray D. Lund
Tags: brain-derived neurotrophic factor, glial cell-line derived neurotrophic factor, rats, retina, schwann cells
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 267-274. doi:https://doi.org/10.1167/iovs.03-0093
Rod and Cone Photoreceptor Function in Patients with Cone Dystrophy Free
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Karen Holopigian; Vivienne C. Greenstein; William Seiple; Donald C. Hood; Ronald E. Carr
Tags: cone dystrophy, retinal cone, rod photoreceptors, electroretinography, erg protein, human
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 275-281. doi:https://doi.org/10.1167/iovs.03-0627
Histological Findings in Experimental Macular Surgery with Indocyanine Green Free
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Salvatore Grisanti; Peter Szurman; Faik Gelisken; Sabin Aisenbrey; Jolanta Oficjalska-Mlynczak; Karl Ulrich Bartz-Schmidt
Tags: indocyanine green, surgical procedures, operative, eye, retina
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 282-286. doi:https://doi.org/10.1167/iovs.03-0797
Oncofetal Fibronectin in Diabetic Retinopathy Free
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Zia A. Khan; Mark Cukiernik; John R. Gonder; Subrata Chakrabarti
Tags: diabetes mellitus, diabetic retinopathy, endothelial cells, endothelin-1, fibronectins
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 287-295. doi:https://doi.org/10.1167/iovs.03-0540
Retinal Function in Normal and Diabetic Eyes Mapped with the Slow Flash Multifocal Electroretinogram Free
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Marcus A. Bearse, Jr; Ying Han; Marilyn E. Schneck; Anthony J. Adams
Tags: diabetes mellitus, electroretinography, eye, retinal diseases, nonproliferative diabetic retinopathy
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 296-304. doi:https://doi.org/10.1167/iovs.03-0424
Contrast-Processing Deficits in Melanoma-Associated Retinopathy Free
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Kenneth R. Alexander; Claire S. Barnes; Gerald A. Fishman; Joel Pokorny; Vivianne C. Smith
Tags: contrast sensitivity, melanoma-associated retinopathy, spatial frequency, visual acuity
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 305-310. doi:https://doi.org/10.1167/iovs.03-0840
Nicotine Increases Size and Severity of Experimental Choroidal Neovascularization Free
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Ivan J. Suñer; Diego G. Espinosa-Heidmann; Maria E. Marin-Castano; Eleut P. Hernandez; Simone Pereira-Simon; Scott W. Cousins
Tags: choroidal neovascularization, nicotine, mice
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 311-317. doi:https://doi.org/10.1167/iovs.03-0733
Delayed Regeneration of Foveal Cone Photopigments in Vogt-Koyanagi-Harada Disease at the Convalescent Stage Free
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Yoko Okamoto; Yozo Miyake; Naoichi Horio; Hideo Takakuwa; Etsuko Yamamoto; Hiroko Terasaki
Tags: retinal cone, uveomeningoencephalitic syndrome, eye, perimetry, densitometry
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 318-322. doi:https://doi.org/10.1167/iovs.03-0381

Retinal Cell Biology

Hepatocyte Growth Factor and its Role in the Pathogenesis of Retinal Detachment Free
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Manlin Jin; Youxin Chen; Shikun He; Stephen J. Ryan; David R. Hinton
Tags: eye, hepatocyte growth factor, pathogenesis, retina, retinal detachment
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 323-329. doi:https://doi.org/10.1167/iovs.03-0355
Ischemia-Induced Changes of AMPA-Type Glutamate Receptor Subunit Expression Pattern in the Rat Retina: A Real-Time Quantitative PCR Study Free
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Frederike Dijk; Elza Kraal-Muller; Willem Kamphuis
Tags: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid, glutamate receptors, ischemia, physiologic reperfusion, quantitative real-time polymerase chain reaction
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 330-341. doi:https://doi.org/10.1167/iovs.03-0285

Visual Psychophysics and Physiological Optics

The Effect of Attention on Conventional Automated Perimetry and Luminance Size Threshold Perimetry Free
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Michael Wall; Kimberly R. Woodward; Caridad F. Brito
Tags: attention, luminance, perimetry
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 342-350. doi:https://doi.org/10.1167/iovs.03-0594
Test–Retest Reliability of Clinical Shack-Hartmann Measurements Free
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Xu Cheng; Nikole L. Himebaugh; Pete S. Kollbaum; Larry N. Thibos; Arthur Bradley
Tags: eye, reliability, weight measurement scales, image quality, astigmatism
Investigative Ophthalmology & Visual Science January 2004, Vol.45, 351-360. doi:https://doi.org/10.1167/iovs.03-0265
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