Select a back issue
Select a back issue
  • Alerts
    User Alerts
    You are adding an alert for:
    Investigative Ophthalmology & Visual Science
    You will receive an email whenever new content is published in the Investigative Ophthalmology & Visual Science. You can manage this and all other alerts in My Account
    The alert will be sent to:
    ×
    This feature is available to authenticated users only.
    Sign In or Create an Account ×

Anatomy and Pathology/Oncology

Modulation of Sub-RPE Deposits In Vitro: A Potential Model for Age-Related Macular Degeneration Free
PDF
Sepideh Amin; N. H. Victor Chong; Tracey A. Bailey; Jinjun Zhang; Carlo Knupp; Michael E. Cheetham; John Greenwood; Philip J. Luthert
Tags: age-related macular degeneration, gelatinase a, tumor necrosis factors, albumins, tissue culture
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1281-1288. doi:https://doi.org/10.1167/iovs.03-0671

Biochemistry and Molecular Biology

Inhibition of Ocular Angiogenesis by an Adenovirus Carrying the Human von Hippel-Lindau Tumor-Suppressor Gene In Vivo Free
PDF
Hideo Akiyama; Toru Tanaka; Hirotaka Itakura; Hiroyoshi Kanai; Tositaka Maeno; Hiroshi Doi; Miki Yamazaki; Kyoichi Takahashi; Yasutaka Kimura; Shoji Kishi; Masahiko Kurabayashi
Tags: adenovirus infections, adenoviruses, angiogenesis, carrying, genes
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1289-1296. doi:https://doi.org/10.1167/iovs.03-0282
Prosaposin Gene Expression in Normal and Dystrophic RCS Rat Retina Free
PDF
Loïc Van Den Berghe; Karine Sainton; Karïn Gogat; Dominique Marchant; Eric Dufour; Sébastien Bonnel; Stéphanie Gadin; Maurice Menasche; Marc Abitbol
Tags: dna, complementary, gene expression, proteins, retina, rna, messenger
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1297-1305. doi:https://doi.org/10.1167/iovs.03-1048
Association of Apolipoprotein E Alleles with Susceptibility to Age-Related Macular Degeneration in a Large Cohort from a Single Center Free
PDF
Sepideh Zareparsi; Adam C. Reddick; Kari E. H. Branham; Kathryn B. Moore; Laurie Jessup; Susan Thoms; Michael Smith-Wheelock; Beverly M. Yashar; Anand Swaroop
Tags: age-related macular degeneration, alleles, apolipoprotein e, cohort studies, disease susceptibility
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1306-1310. doi:https://doi.org/10.1167/iovs.03-1253

Clinical and Epidemiologic Research

The ε2 and ε4 Alleles of the Apolipoprotein Gene Are Associated with Age-Related Macular Degeneration Free
PDF
Paul N. Baird; Elizabeth Guida; Diep T. Chu; Hien T. V. Vu; Robyn H. Guymer
Tags: age-related macular degeneration, alleles, apolipoprotein e, apolipoproteins, atrophic condition of skin
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1311-1315. doi:https://doi.org/10.1167/iovs.03-1121
Incidence and Cumulative Risk of Childhood Cataract in a Cohort of 2.6 Million Danish Children Free
PDF
Birgitte Haargaard; Jan Wohlfahrt; Hans Callø Fledelius; Thomas Rosenberg; Mads Melbye
Tags: cataract, cataract, childhood, child, cohort studies, danish
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1316-1320. doi:https://doi.org/10.1167/iovs.03-0635
Significant Nonsurgical Risk Factors for Endophthalmitis after Cataract Surgery: EPSWA Fourth Report Free
PDF
Jianghong Li; Nigel Morlet; Jonathon Q. Ng; James B. Semmens; Matthew W. Knuiman
Tags: cataract surgery, endophthalmitis, risk factors, surgical procedures, operative, postoperative care
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1321-1328. doi:https://doi.org/10.1167/iovs.03-1000

Cornea

Urokinase-Type Plasminogen Activator to Prevent Haze after Photorefractive Keratectomy, and Pregnancy as a Risk Factor for Haze in Rabbits Free
PDF
Adrienne Csutak; David M. Silver; József Tözsér; Ziad Hassan; András Berta
Tags: corneal opacity, oryctolagus cuniculus, pregnancy, risk factors, urokinase
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1329-1333. doi:https://doi.org/10.1167/iovs.03-0881
Corneal Healing after Uncomplicated LASIK and Its Relationship to Refractive Changes: A Six-Month Prospective Confocal Study Free
PDF
Avni Murat Avunduk; Carl Joseph Senft; Sherif Emerah; Emily D. Varnell; Herbert E. Kaufman
Tags: cornea, keratomileusis, laser in situ, healing process, wound healing, surgical flaps
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1334-1339. doi:https://doi.org/10.1167/iovs.03-1025
Effect of Overexpressing the Transcription Factor E2F2 on Cell Cycle Progression in Rabbit Corneal Endothelial Cells Free
PDF
Nancy C. Joyce; Deshea L. Harris; James C. Mc Alister; Robin R. Ali; Daniel F. P. Larkin
Tags: cell cycle, cornea, endothelial cells, oryctolagus cuniculus, protein overexpression
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1340-1348. doi:https://doi.org/10.1167/iovs.03-0335
Corneal Asphericity Change after Excimer Laser Hyperopic Surgery: Theoretical Effects on Corneal Profiles and Corresponding Zernike Expansions Free
PDF
Damien Gatinel; Jacques Malet; Thanh Hoang-Xuan; Dimitri T. Azar
Tags: ablation, cornea, hyperopia, postoperative care, excimer lasers
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1349-1359. doi:https://doi.org/10.1167/iovs.03-0753
Conjunctival Proinflammatory and Proapoptotic Effects of Latanoprost and Preserved and Unpreserved Timolol: An Ex Vivo and In Vitro Study Free
PDF
Pierre-Jean Pisella; Caroline Debbasch; Pascale Hamard; Catherine Creuzot-Garcher; Patrice Rat; Françoise Brignole; Christophe Baudouin
Tags: bronchioloalveolar carcinoma, conjunctiva, latanoprost, timolol, flow cytometry
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1360-1368. doi:https://doi.org/10.1167/iovs.03-1067
A New Noninvasive Tear Stability Analysis System for the Assessment of Dry Eyes Free
PDF
Takashi Kojima; Reiko Ishida; Murat Dogru; Eiki Goto; Yoji Takano; Yukihiro Matsumoto; Minako Kaido; Yuichi Ohashi; Kazuo Tsubota
Tags: dry eye syndromes, serotonin uptake inhibitors
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1369-1374. doi:https://doi.org/10.1167/iovs.03-0712
Prophylactic Effect of IL-10 Gene Transfer on Induced Autoimmune Dacryoadenitis Free
PDF
Zejin Zhu; Douglas Stevenson; Joel E. Schechter; Austin K. Mircheff; Thomas Ritter; Laurie Labree; Melvin D. Trousdale
Tags: autoimmune diseases, autoimmunity, dacryoadenitis, gene transfer techniques, interleukin-10
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1375-1381. doi:https://doi.org/10.1167/iovs.03-0755
Two Mutations in the TGFBI (BIGH3) Gene Associated with Lattice Corneal Dystrophy in an Extensively Studied Family Free
PDF
Gordon K. Klintworth; Wenjun Bao; Natalie A. Afshari
Tags: family, genes, meretoja syndrome, mutation, cornea
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1382-1388. doi:https://doi.org/10.1167/iovs.03-1228

Glaucoma

Expression Analysis of the Matrix GLA Protein and VE-Cadherin Gene Promoters in the Outflow Pathway Free
PDF
Pedro Gonzalez; Montserrat Caballero; Paloma B. Liton; W. Daniel Stamer; David L. Epstein
Tags: cadherins, eye, galactosidase, genes, oncogenes
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1389-1395. doi:https://doi.org/10.1167/iovs.03-0537
Optimizing and Validating an Approach for Identifying Glaucomatous Change in Optic Nerve Topography Free
PDF
James C. H. Tan; Roger A. Hitchings
Tags: eye, optic nerve, glaucoma, optic disk
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1396-1403. doi:https://doi.org/10.1167/iovs.03-0025
Quantifying Retinal Nerve Fiber Layer Thickness Histologically: A Novel Approach to Sectioning of the Retina Free
PDF
Eytan Z. Blumenthal
Tags: eye, retina, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1404-1409. doi:https://doi.org/10.1167/iovs.03-0744
Increased Expression of Iron-Regulating Genes in Monkey and Human Glaucoma Free
PDF
Ronald H. Farkas; Itay Chowers; Abigail S. Hackam; Masaki Kageyama; Robert W. Nickells; Deborah C. Otteson; Elia J. Duh; Chenwei Wang; Danielle F. Valenta; Tushara L. Gunatilaka; Mary E. Pease; Harry A. Quigley; Donald J. Zack
Tags: cercopithecidae, genes, glaucoma, immunohistochemistry, iron
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1410-1417. doi:https://doi.org/10.1167/iovs.03-0872

Immunology and Microbiology

Laboratory Investigation of Acanthamoeba lugdunensis from Patients with Keratitis Free
PDF
Hak-Sun Yu; Hyun-Hee Kong; So-Youl Kim; Young-Ho Hahn; Tae-Won Hahn; Dong-Il Chung
Tags: acanthamoeba, dna, mitochondrial, dna, ribosomal, keratitis, restriction fragment length polymorphism
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1418-1426. doi:https://doi.org/10.1167/iovs.03-0433

Lens

Regional Differences in Tyrosine Kinase Receptor Signaling Components Determine Differential Growth Patterns in the Human Lens Free
PDF
Jill M. Maidment; George Duncan; Shigeo Tamiya; David J. Collison; Lixin Wang; I. Michael Wormstone
Tags: epidermal growth factor receptors, epithelium, geographic difference, lens (device), protein tyrosine kinase
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1427-1435. doi:https://doi.org/10.1167/iovs.03-1187
CRYBA3/A1 Gene Mutation Associated with Suture-Sparing Autosomal Dominant Congenital Nuclear Cataract: A Novel Phenotype Free
PDF
Walter Ferrini; Daniel F. Schorderet; Philippe Othenin-Girard; Sylvie Uffer; Elise Héon; Francis L. Munier
Tags: cataract, nuclear, mutation, phenotype, sutures, genetic linkage analysis
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1436-1441. doi:https://doi.org/10.1167/iovs.03-0760

Physiology and Pharmacology

Retinal Colocalization and In Vitro Interaction of the Glutamate Receptor EAAT3 and the Serum- and Glucocorticoid-Inducible Kinase SGK1 Free
PDF
Roman Schniepp; Konrad Kohler; Thomas Ladewig; Elke Guenther; Guido Henke; Monica Palmada; Christoph Boehmer; Jeffrey D. Rothstein; Stefan Bröer; Florian Lang
Tags: glucocorticoids, glutamate, glutamate receptors, glutamates, phosphotransferases
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1442-1449. doi:https://doi.org/10.1167/iovs.03-0062

Retina

Comparison of Objective Retinal Thickness Analysis and Subjective Stereo Fundus Photography in Diabetic Macular Edema Free
PDF
Charlotte Strøm; Birgit Sander
Tags: diabetic macular edema, fundus photography, eye
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1450-1455. doi:https://doi.org/10.1167/iovs.03-0780
MERTK Arginine-844-Cysteine in a Patient with Severe Rod–Cone Dystrophy: Loss of Mutant Protein Function in Transfected Cells Free
PDF
Christina L. McHenry; Yuhui Liu; Wei Feng; Anita R. Nair; Kecia L. Feathers; Xiaoling Ding; Andreas Gal; Douglas Vollrath; Paul A. Sieving; Debra A. Thompson
Tags: cysteine, mertk gene, retinitis pigmentosa, arginine, mutant proteins
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1456-1463. doi:https://doi.org/10.1167/iovs.03-0909
Hyperspectral Imaging for Measurement of Oxygen Saturation in the Optic Nerve Head Free
PDF
Bahram Khoobehi; James M. Beach; Hiroyuki Kawano
Tags: diagnostic imaging, intraocular pressure, optic disk, oxygen, oxygen saturation measurement
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1464-1472. doi:https://doi.org/10.1167/iovs.03-1069
Apoptosis in Proliferative Vitreoretinopathy Free
PDF
Ibraheem El Ghrably; Des G. Powe; Gavin Orr; David Fischer; Richard McIntosh; Harminder S. Dua; Patrick J. Tighe
Tags: apoptosis, proteins, rna, messenger, tumor necrosis factor ligand superfamily member 6, vitreoretinopathy, proliferative
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1473-1479. doi:https://doi.org/10.1167/iovs.03-0060
Novel Complex GUCY2D Mutation in Japanese Family with Cone-Rod Dystrophy Free
PDF
Sei Ito; Makoto Nakamura; Yoshihisa Nuno; Yoshitaka Ohnishi; Teruo Nishida; Yozo Miyake
Tags: family, japanese, mutation, progressive cone-rod dystrophy, retinitis pigmentosa
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1480-1485. doi:https://doi.org/10.1167/iovs.03-0315
Age, Blood Pressure, and Vessel Diameter as Factors Influencing the Arterial Retinal Flicker Response Free
PDF
Edgar Nagel; Walthard Vilser; Ines Lanzl
Tags: diameter, photopsia, blood pressure
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1486-1492. doi:https://doi.org/10.1167/iovs.03-0667
The Influence of Path Length and Matrix Components on Ageing Characteristics of Transport between the Choroid and the Outer Retina Free
PDF
Jost Hillenkamp; Ali A. Hussain; Timothy L. Jackson; Joanna R. Cunningham; John Marshall
Tags: biological transport, bruch's basal membrane, choroid, retina, taurine
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1493-1498. doi:https://doi.org/10.1167/iovs.03-0765
Effect of Somatostatin on Nitric Oxide Production in Human Retinal Pigment Epithelium Cell Cultures Free
PDF
Anna Vasilaki; Thekla Papadaki; George Notas; George Kolios; Niki Mastrodimou; Daniel Hoyer; Miltiadis Tsilimbaris; Elias Kouroumalis; Ioannis Pallikaris; Kyriaki Thermos
Tags: cell culture techniques, nitric oxide, somatostatin, retinal pigment epithelium, retinal pigment cell
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1499-1506. doi:https://doi.org/10.1167/iovs.03-0835

Retinal Cell Biology

Adrenomedullin Affects Two Signal Transduction Pathways and the Migration in Retinal Pigment Epithelial Cells Free
PDF
Wei Huang; Lin Wang; Ming Yuan; Jixian Ma; Yannian Hui
Tags: adrenomedullin, cyclic amp, cyclic gmp, retinal pigment cell, signal transduction pathways
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1507-1513. doi:https://doi.org/10.1167/iovs.03-0731
Effect of Erythropoietin Axotomy-Induced Apoptosis in Rat Retinal Ganglion Cells Free
PDF
Jochen H. Weishaupt; Gundula Rohde; Esther Pölking; Anna-Leena Siren; Hannelore Ehrenreich; Mathias Bähr
Tags: apoptosis, axotomy, erythropoietin, proto-oncogene proteins c-akt, caspase-3
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1514-1522. doi:https://doi.org/10.1167/iovs.03-1039
Protection by Pyruvate of Rat Retinal Cells against Zinc Toxicity In Vitro, and Pressure-Induced Ischemia In Vivo Free
PDF
Min Heui Yoo; Joo-Yong Lee; Song Eun Lee; Jae-Young Koh; Young Hee Yoon
Tags: cell culture techniques, ischemia, pyruvates, zinc, zinc phosphide toxicity
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1523-1530. doi:https://doi.org/10.1167/iovs.03-1315
Acetylcholine Protection of Adult Pig Retinal Ganglion Cells from Glutamate-Induced Excitotoxicity Free
PDF
Erica Wehrwein; Sean A. Thompson; Sylvie F. Coulibaly; David M. Linn; Cindy L. Linn
Tags: acetylcholine, adult, excitotoxicity, glutamate, retinal ganglion cells
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1531-1543. doi:https://doi.org/10.1167/iovs.03-0406
Localization of Collagen XVIII and the Endostatin Portion of Collagen XVIII in Aged Human Control Eyes and Eyes with Age-Related Macular Degeneration Free
PDF
Imran A. Bhutto; Sahng Y. Kim; D. Scott McLeod; Carol Merges; Naomi Fukai; Bjorn R. Olsen; Gerard A. Lutty
Tags: age-related macular degeneration, endostatins, eye, choroid, retina
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1544-1552. doi:https://doi.org/10.1167/iovs.03-0862
Nuclear Translocation of Glyceraldehyde-3-Phosphate Dehydrogenase: A Role in High Glucose-Induced Apoptosis in Retinal Müller Cells Free
PDF
Linda L. Kusner; Vijay P. Sarthy; Susanne Mohr
Tags: apoptosis, deprenyl, glucose, glyceraldehyde-3-phosphate dehydrogenases, nuclear translocation
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1553-1561. doi:https://doi.org/10.1167/iovs.03-1294
Topographic and Age-Dependent Expression of Heme Oxygenase-1 and Catalase in the Human Retinal Pigment Epithelium Free
PDF
Noritake Miyamura; Tsukihiko Ogawa; Sharon Boylan; Lawrence S. Morse; James T. Handa; Leonard M. Hjelmeland
Tags: catalase, heme, in situ hybridization, oxygenases, retinal pigment epithelium
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1562-1565. doi:https://doi.org/10.1167/iovs.02-0761

Visual Psychophysics and Physiological Optics

Spatial Vision Deficits in Infants and Children with Down Syndrome Free
PDF
Ffion M. John; Nathan R. Bromham; J. Margaret Woodhouse; T. Rowan Candy
Tags: child, down syndrome, evoked potentials, visual, infant, spatial vision
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1566-1572. doi:https://doi.org/10.1167/iovs.03-0951

Erratum

Erratum Free
PDF
Investigative Ophthalmology & Visual Science May 2004, Vol.45, 1296. doi:
Copyright © 2025 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×