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Biochemistry and Molecular Biology

Declines in Arrestin and Rhodopsin in the Macula with Progression of Age-Related Macular Degeneration Free
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Cheryl M. Ethen; Xiao Feng; Timothy W. Olsen; Deborah A. Ferrington
Tags: age-related macular degeneration, arrestin, macula densa, macula lutea, proteins
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 769-775. doi:https://doi.org/10.1167/iovs.04-0810
Effect of UV-A and UV-B Irradiation on the Metabolic Profile of Aqueous Humor in Rabbits Analyzed by 1H NMR Spectroscopy Free
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May-Britt Tessem; Tone F. Bathen; Jitka Čejková; Anna Midelfart
Tags: aqueous humor, oryctolagus cuniculus, spectrum analysis, ultraviolet a radiation, ultraviolet b radiation
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 776-781. doi:https://doi.org/10.1167/iovs.04-0787
Cyclosporin A Inhibits Calcineurin/Nuclear Factor of Activated T-Cells Signaling and Induces Apoptosis in Retinoblastoma Cells Free
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Lauren A. Eckstein; Kurtis R. Van Quill; Steven K. Bui; Marita S. Uusitalo; Joan M. O’Brien
Tags: apoptosis, calcineurin, cyclosporine, nuclear factor of activated t-cells, retinoblastoma
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 782-790. doi:https://doi.org/10.1167/iovs.04-1022
Deleted in Polyposis 1-like 1 Gene (Dp1l1): A Novel Gene Richly Expressed in Retinal Ganglion Cells Free
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Hajime Sato; Hiroshi Tomita; Toru Nakazawa; Shigeharu Wakana; Makoto Tamai
Tags: dna, complementary, genes, mice, multiple polyps, proteins
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 791-796. doi:https://doi.org/10.1167/iovs.04-0867

Cornea

Protection of Human Conjunctival Fibroblasts from NO-Induced Apoptosis by Interleukin-4 or Interleukin-13 Free
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Youichiro Fujitsu; Ken Fukuda; Kazuhiro Kimura; Keisuke Seki; Naoki Kumagai; Teruo Nishida
Tags: apoptosis, conjunctiva, fibroblasts, interleukin-13, interleukin-4
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 797-802. doi:https://doi.org/10.1167/iovs.04-1016
Survival of Donor Epithelial Cells after Limbal Stem Cell Transplantation Free
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Ali R. Djalilian; Sankaranarayana P. Mahesh; Christian A. Koch; Robert B. Nussenblatt; DeFen Shen; Zhengpin Zhuang; Edward J. Holland; Chi-Chao Chan
Tags: cornea, dna, donors, epithelial cells, hematopoietic stem cell transplantation
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 803-807. doi:https://doi.org/10.1167/iovs.04-0575
Role of Matrix Metalloproteinase-9 in Ex Vivo Expansion of Human Limbal Epithelial Cells Cultured on Human Amniotic Membrane Free
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Chi-Chin Sun; Ching-Yi Cheng; Chin-Sung Chien; Jong-Hwei Su Pang; Wan-Chen Ku; Phil Yeong-Fong Chen; Chuen-Mao Yang
Tags: epithelial cells, gelatinase b, amnion
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 808-815. doi:https://doi.org/10.1167/iovs.04-0370
Animal Compound–Free Medium and Poloxamer for Human Corneal Organ Culture and Deswelling Free
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Gilles Thuret; Chloe Manissolle; Lydia Campos-Guyotat; Denis Guyotat; Philippe Gain
Tags: cornea, dextran, endothelium, organ culture techniques, poloxamer
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 816-822. doi:https://doi.org/10.1167/iovs.04-1078
Increased Levels of Catalase and Cathepsin V/L2 but Decreased TIMP-1 in Keratoconus Corneas: Evidence that Oxidative Stress Plays a Role in This Disorder Free
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M. Cristina Kenney; Marilyn Chwa; Shari R. Atilano; Annie Tran; Marilee Carballo; Mehrnoosh Saghizadeh; Vasilis Vasiliou; Wakako Adachi; Donald J. Brown
Tags: catalase, cathepsins, cornea, keratoconus, oxidative stress
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 823-832. doi:https://doi.org/10.1167/iovs.04-0549
Sensitizing Effect of Substance P on Corneal Epithelial Migration Induced by IGF-1, Fibronectin, or Interleukin-6 Free
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Naoyuki Yamada; Ryoji Yanai; Makoto Inui; Teruo Nishida
Tags: amides, cornea, epithelium, fibronectins, insulin-like growth factor i
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 833-839. doi:https://doi.org/10.1167/iovs.04-0775
Doxycycline Inhibits TGF-β1–Induced MMP-9 via Smad and MAPK Pathways in Human Corneal Epithelial Cells Free
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Hyun-Seung Kim; Lihui Luo; Stephen C. Pflugfelder; De-Quan Li
Tags: corneal epithelial cells, doxycycline, gelatinase b, mitogen-activated protein kinases
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 840-848. doi:https://doi.org/10.1167/iovs.04-0929
Detection and Subcellular Localization of Two 15S-Lipoxygenases in Human Cornea Free
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Min S. Chang; Claus Schneider; Richard L. Roberts; Scott B. Shappell; Fredrick R. Haselton; William E. Boeglin; Alan R. Brash
Tags: arachidonate 15-lipoxygenase, arachidonic acid, cornea, hydroxyeicosatetraenoic acids, lipoxygenase
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 849-856. doi:https://doi.org/10.1167/iovs.04-1166

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Upper and Lower Eyelid Saccades Describe a Harmonic Oscillator Function Free
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Jorge M. C. Malbouisson; Antonio Augusto Velasco e Cruz; André Messias; Lívio V. O. Leite; Gilmasa D. Rios
Tags: eyelid, harmonics, saccades, velocity
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 857-862. doi:https://doi.org/10.1167/iovs.04-1086

Glaucoma

SELDI-TOF-MS ProteinChip Array Profiling of Tears from Patients with Dry Eye Free
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Franz H. Grus; Vladimir N. Podust; Kai Bruns; Karl Lackner; Siyu Fu; Enrique A. Dalmasso; Anton Wirthlin; Norbert Pfeiffer
Tags: dry eye syndromes, proteins, biological markers, peptides, lasers
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 863-876. doi:https://doi.org/10.1167/iovs.04-0448
Systemic Reduction in Glutathione Levels Occurs in Patients with Primary Open-Angle Glaucoma Free
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Doina Gherghel; Helen Rosemary Griffiths; Emma Jane Hilton; Ian Andrew Cunliffe; Sarah Louise Hosking
Tags: glaucoma, glutathione, glutathione disulfide, open-angle glaucoma
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 877-883. doi:https://doi.org/10.1167/iovs.04-0777
Effect of Glatiramer Acetate on Primary and Secondary Degeneration of Retinal Ganglion Cells in the Rat Free
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Michael Blair; Mary Ellen Pease; John Hammond; Danielle Valenta; Jennifer Kielczewski; Hana Levkovitch-Verbin; Harry Quigley
Tags: glatiramer acetate, optic nerve, retina, retinal ganglion cells, wallerian degeneration
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 884-890. doi:https://doi.org/10.1167/iovs.04-0731
Analysis of Retinal Nerve Fiber Layer and Optic Nerve Head in Glaucoma with Different Reference Plane Offsets, Using Optical Coherence Tomography Free
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Christopher Kai-shun Leung; Wai-man Chan; Yung-lam Hui; Wing-ho Yung; Jackson Woo; Moon-kwong Tsang; Kwok-kay Tse
Tags: glaucoma, optic disk, optical coherence tomography, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 891-899. doi:https://doi.org/10.1167/iovs.04-1107

Immunology and Microbiology

Immunosuppressive Factors Secreted by Human Amniotic Epithelial Cells Free
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Haochuan Li; Jerry Y. Niederkorn; Sudha Neelam; Elizabeth Mayhew; R. Ann Word; James P. McCulley; Hassan Alizadeh
Tags: amnion, apoptosis, epithelial cells, hay-wells syndrome, immunosuppressive agents
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 900-907. doi:https://doi.org/10.1167/iovs.04-0495
Thrombospondin Plays a Vital Role in the Immune Privilege of the Eye Free
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Parisa Zamiri; Sharmila Masli; Nobuyoshi Kitaichi; Andrew W. Taylor; J. Wayne Streilein
Tags: eye, mice, mice, inbred c57bl, t-cell activation, thrombospondin 1
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 908-919. doi:https://doi.org/10.1167/iovs.04-0362

Lens

The Effect of Cataract Surgery on Postural Control Free
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Shulamit Schwartz; Ori Segal; Yaniv Barkana; Rene Schwesig; Isaac Avni; Yair Morad
Tags: cataract surgery, regulation of posture, surgical procedures, operative, eye
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 920-924. doi:https://doi.org/10.1167/iovs.04-0543
Characterization and Functional Activity of Thrombin Receptors in the Human Lens Free
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Colin James; David J. Collison; George Duncan
Tags: lens, crystalline, receptor, par-1, thrombin, thrombin receptor, proto-oncogene proteins c-akt
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 925-932. doi:https://doi.org/10.1167/iovs.04-0523

Physiology and Pharmacology

The Peptides ADNF-9 and NAP Increase Survival and Neurite Outgrowth of Rat Retinal Ganglion Cells In Vitro Free
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Wolf A. Lagrèze; Amelie Pielen; Ruth Steingart; Günther Schlunck; Hans-Dieter Hofmann; Illana Gozes; Matthias Kirsch
Tags: neurites, peptides, retinal ganglion cells, brain-derived neurotrophic factor, ciliary neurotrophic factor
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 933-938. doi:https://doi.org/10.1167/iovs.04-0766
Spontaneous Fluid Transport across Isolated Rabbit and Bovine Ciliary Body Preparations Free
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Oscar A. Candia; Chi-Ho To; Rosana M. Gerometta; Aldo C. Zamudio
Tags: bathing, body tissue, cattle, ciliary body, ciliary epithelium
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 939-947. doi:https://doi.org/10.1167/iovs.04-0950
Inhibition of Swelling-Activated Cl− Currents by Functional Anti-ClC-3 Antibody in Native Bovine Non-Pigmented Ciliary Epithelial Cells Free
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Chi Wai Do; Wennan Lu; Claire H. Mitchell; Mortimer M. Civan
Tags: antibodies, cattle, edema, epithelial cells, hypotonicity
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 948-955. doi:https://doi.org/10.1167/iovs.04-1004
Light-Induced Retinal Vascular Damage by Pd-porphyrin Luminescent Oxygen Probes Free
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Thomas K. Stepinac; Stephane R. Chamot; Elisabeth Rungger-Brändle; Pierre Ferrez; Jean-Luc Munoz; Hubert van den Bergh; Claude E. Riva; Constantin J. Pournaras; Georges A. Wagnières
Tags: body tissue, dyes, eye, optic disk, oxygen
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 956-966. doi:https://doi.org/10.1167/iovs.04-0500

Retina

Cyclic AMP Prevents Retraction of Axon Terminals in Photoreceptors Prepared for Transplantation: An In Vitro Study Free
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Mohamad A. Khodair; Marco A. Zarbin; Ellen Townes-Anderson
Tags: cyclic amp, photoreceptors, presynaptic terminals, transplantation
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 967-973. doi:https://doi.org/10.1167/iovs.04-0579
Use of Optical Coherence Tomography to Assess Variations in Macular Retinal Thickness in Myopia Free
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Marcus C. C. Lim; Sek-Tien Hoh; Paul J. Foster; Tock-Han Lim; Sek-Jin Chew; Steve K. L. Seah; Tin Aung
Tags: myopia, optical coherence tomography
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 974-978. doi:https://doi.org/10.1167/iovs.04-0828
Sulforaphane Induces Thioredoxin through the Antioxidant-Responsive Element and Attenuates Retinal Light Damage in Mice Free
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Masaki Tanito; Hiroshi Masutani; Yong-Chul Kim; Mai Nishikawa; Akihiro Ohira; Junji Yodoi
Tags: antioxidants, mice, sulforaphane, thioredoxin, retinal pigment cell
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 979-987. doi:https://doi.org/10.1167/iovs.04-1120
Laser-Induced Changes in Intraretinal Oxygen Distribution in Pigmented Rabbits Free
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Dao-Yi Yu; Stephen J. Cringle; Erning Su; Paula K. Yu; Mark S. Humayun; Giorgio Dorin
Tags: lasers, oxygen, retina, oryctolagus cuniculus
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 988-999. doi:https://doi.org/10.1167/iovs.04-0767
Basement Membrane–Dependent Survival of Retinal Ganglion Cells Free
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Willi Halfter; Michael Willem; Ulrike Mayer
Tags: basement membrane, embryo, eye, glasgow coma scale, laminin
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 1000-1009. doi:https://doi.org/10.1167/iovs.04-1185
Retinal Disease in Mice Lacking Hypoxia-Inducible Transcription Factor-2α Free
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Kan Ding; Marzia Scortegagna; Robyn Seaman; David G. Birch; Joseph A. Garcia
Tags: hypoxia, mice, retinal diseases
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 1010-1016. doi:https://doi.org/10.1167/iovs.04-0788
Objective Signs of Photoreceptor Displacement by Binocular Correspondence Perimetry: A Study of Epiretinal Membranes Free
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Kristian Krøyer; Ole Mark Jensen; Michael Larsen
Tags: epiretinal membrane, perimetry, photoreceptors, metamorphopsias
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 1017-1022. doi:https://doi.org/10.1167/iovs.04-0952
Measurement of Macular Pigment: Raman Spectroscopy versus Heterochromatic Flicker Photometry Free
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Kumari Neelam; Nicholas O’Gorman; John Nolan; Orla O’Donovan; Hwee Bee Wong; Kah Guan Au Eong; Stephen Beatty
Tags: eye, photometry, photopsia, pigment, reading (activity)
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 1023-1032. doi:https://doi.org/10.1167/iovs.04-1032
Reduced Foveolar Choroidal Blood Flow in Eyes with Increasing AMD Severity Free
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Juan E. Grunwald; Tatyana I. Metelitsina; Joan C. DuPont; Gui-Shuang Ying; Maureen G. Maguire
Tags: choroidal neovascularization, eye, vascular flow, drusen
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 1033-1038. doi:https://doi.org/10.1167/iovs.04-1050

Retinal Cell Biology

Mechanisms of Apoptosis in Human Retinal Pigment Epithelium Induced by TNF-α in Conditions of Heavy Metal Ion Deficiency Free
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Jun-Hai Yang; Wei-Dong Le; Scott F. Basinger; Samuel M. Wu; Chao-yuh Yang
Tags: apoptosis, caspases, metals, heavy, tumor necrosis factors, cyclosporine
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 1039-1046. doi:https://doi.org/10.1167/iovs.04-0325
Functional Characterization and Comparison of the Outer Blood–Retina Barrier and the Blood–Brain Barrier Free
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Heiko Steuer; Andreas Jaworski; Bernd Elger; Martin Kaussmann; Jörg Keldenich; Herbert Schneider; Dieter Stoll; Burkhard Schlosshauer
Tags: blood-brain barrier, body tissue, brain, permeability, p-glycoprotein
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 1047-1053. doi:https://doi.org/10.1167/iovs.04-0925
Oxidant-Induced Apoptosis in Human Retinal Pigment Epithelial Cells: Dependence on Extracellular Redox State Free
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Shunai Jiang; Siobhan E. Moriarty-Craige; Michael Orr; Jiyang Cai; Paul Sternberg, Jr; Dean P. Jones
Tags: apoptosis, oxidants, oxidation-reduction, retinal pigment cell, tumor necrosis factor ligand superfamily member 6
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 1054-1061. doi:https://doi.org/10.1167/iovs.04-0949
Vascular Endothelial Growth Factor Reduced and Connective Tissue Growth Factor Induced by Triamcinolone in ARPE19 Cells under Oxidative Stress Free
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Satoshi Matsuda; Fumi Gomi; Yusuke Oshima; Masaya Tohyama; Yasuo Tano
Tags: connective tissue growth factor, oxidative stress, vascular endothelial growth factor a, triamcinolone, retinal pigment cell
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 1062-1068. doi:https://doi.org/10.1167/iovs.04-0761
The Renin-Angiotensin System and the Developing Retinal Vasculature Free
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Stella Sarlos; Jennifer L. Wilkinson-Berka
Tags: angiotensin ii, rats, renin-angiotensin system, retina, retinal vasculature
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 1069-1077. doi:https://doi.org/10.1167/iovs.04-0885
Selective Suppression of Pathologic, but Not Physiologic, Retinal Neovascularization by Blocking the Angiotensin II Type 1 Receptor Free
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Norihiro Nagai; Kousuke Noda; Takashi Urano; Yoshiaki Kubota; Hajime Shinoda; Takashi Koto; Kei Shinoda; Makoto Inoue; Takayuki Shiomi; Eiji Ikeda; Kazuo Tsubota; Toshio Suda; Yuichi Oike; Susumu Ishida
Tags: intercellular adhesion molecule 1, ischemia, receptor, angiotensin, type 1, retinal diseases, retinal neovascularization
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 1078-1084. doi:https://doi.org/10.1167/iovs.04-1101
Heat Shock Protein 27 Delays Ca2+-Induced Cell Death in a Caspase-Dependent and -Independent Manner in Rat Retinal Ganglion Cells Free
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N. Andrew Whitlock; Kristie Lindsey; Neeraj Agarwal; Craig E. Crosson; Jian-Xing Ma
Tags: caspase-3, caspases, cell death, cell survival, heat-shock proteins
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 1085-1091. doi:https://doi.org/10.1167/iovs.04-0042
Hsp27 Upregulation by HIF-1 Signaling Offers Protection against Retinal Ischemia in Rats Free
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N. Andrew Whitlock; Neeraj Agarwal; Jian-Xing Ma; Craig E. Crosson
Tags: introns, ischemia, proteins, rats, retinal ischemia
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 1092-1098. doi:https://doi.org/10.1167/iovs.04-0043

Visual Psychophysics and Physiological Optics

Improved Contrast of Peripapillary Hyperpigmentation Using Polarization Analysis Free
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Mariane B. Mellem-Kairala; Ann E. Elsner; Anke Weber; Ruthanne B. Simmons; Stephen A. Burns
Tags: hyperpigmentation, fundus photography, color
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 1099-1106. doi:https://doi.org/10.1167/iovs.04-0574
Critical Flicker Frequency as a Potential Vision Technique in the Presence of Cataracts Free
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Guillermo Bueno del Romo; William A. Douthwaite; David B. Elliott
Tags: cataract, photopsia, vision
Investigative Ophthalmology & Visual Science March 2005, Vol.46, 1107-1112. doi:https://doi.org/10.1167/iovs.04-1138

Erratum

January 2005 Cover Legend Free
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Investigative Ophthalmology & Visual Science March 2005, Vol.46, 775. doi:
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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