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Anatomy and Pathology/Oncology

Ocular Rigidity in Living Human Eyes Free
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Ioannis G. Pallikaris; George D. Kymionis; Harilaos S. Ginis; George A. Kounis; Miltiadis K. Tsilimbaris
Tags: eye, muscle rigidity
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 409-414. doi:https://doi.org/10.1167/iovs.04-0162
Murine Model of Primary Intraocular Lymphoma Free
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Chi-Chao Chan; Maria Fischette; DeFen Shen; Sankaranarayana P. Mahesh; Robert B. Nussenblatt; Jacob Hochman
Tags: eye, interleukin-10, lymphoma, lymphoma, intraocular, mice
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 415-419. doi:https://doi.org/10.1167/iovs.04-0869

Biochemistry and Molecular Biology

Congenital Stromal Dystrophy of the Cornea Caused by a Mutation in the Decorin Gene Free
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Cecilie Bredrup; Per M. Knappskog; Jacek Majewski; Eyvind Rødahl; Helge Boman
Tags: cornea, genes, mutation, family, eye
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 420-426. doi:https://doi.org/10.1167/iovs.04-0804
Mechanism of Protection from Light-Induced Retinal Degeneration by the Synthetic Antioxidant Phenyl-N-tert-Butylnitrone Free
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Hiroshi Tomita; Yashige Kotake; Robert E. Anderson
Tags: antioxidants, apoptosis, caspase-3, c-fos genes, light exposure
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 427-434. doi:https://doi.org/10.1167/iovs.04-0946
A Single, Abbreviated RPGR-ORF15 Variant Reconstitutes RPGR Function In Vivo Free
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Dong-Hyun Hong; Basil S. Pawlyk; Michael Adamian; Michael A. Sandberg; Tiansen Li
Tags: animals, transgenic, cilia, electroretinography, fluorescent antibody technique, immunoblotting
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 435-441. doi:https://doi.org/10.1167/iovs.04-1065

Clinical and Epidemiologic Research

Support for Polygenic Influences on Ocular Refractive Error Free
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Alison P. Klein; Priya Duggal; Kristine E. Lee; Ronald Klein; Joan E. Bailey-Wilson; Barbara E. K. Klein
Tags: refractive errors
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 442-446. doi:https://doi.org/10.1167/iovs.04-0794
Risk Factors for Postsurgical Trichiasis Recurrence in a Trachoma-Endemic Area Free
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Emily S. West; Harran Mkocha; Beatriz Munoz; David Mabey; Allen Foster; Robin Bailey; Sheila K. West
Tags: eyelid trichiasis, recurrence, risk factors, surgical procedures, operative, trachoma
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 447-453. doi:https://doi.org/10.1167/iovs.04-0600

Cornea

Inhibitory Effect of Rapamycin on Corneal Neovascularization In Vitro and In Vivo Free
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Young Sam Kwon; Hyun Sook Hong; Jae Chan Kim; Jun Seop Shin; Youngsook Son
Tags: corneal neovascularization, rapamycin
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 454-460. doi:https://doi.org/10.1167/iovs.04-0753
A Time Course Microarray Study of Gene Expression in the Mouse Lacrimal Gland after Acute Corneal Trauma Free
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Yuan Fang; Dongseok Choi; Robert P. Searles; William D. Mathers
Tags: corneal injuries, gene expression, genes, lacrimal gland, mice
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 461-469. doi:https://doi.org/10.1167/iovs.04-0677
Characterization of Growth and Differentiation in a Telomerase-Immortalized Human Corneal Epithelial Cell Line Free
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Danielle M. Robertson; Li Li; Stephen Fisher; Virginia P. Pearce; Jerry W. Shay; Woodring E. Wright; H. Dwight Cavanagh; James V. Jester
Tags: corneal epithelial cells, telomerase, epithelial cells, cornea, proteins
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 470-478. doi:https://doi.org/10.1167/iovs.04-0528
Soluble Lumican Glycoprotein Purified from Human Amniotic Membrane Promotes Corneal Epithelial Wound Healing Free
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Lung-Kun Yeh; Wei-Li Chen; Wei Li; Edgar M. Espana; Jie Ouyang; Tetsuya Kawakita; Winston W.-Y. Kao; Scheffer C. G. Tseng; Chia-Yang Liu
Tags: amnion, antibodies, cornea, epithelium, glycoproteins
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 479-486. doi:https://doi.org/10.1167/iovs.04-1014
PAF-Induced Furin and MT1-MMP Expression Is Independent of MMP-2 Activation in Corneal Myofibroblasts Free
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Paulo Ottino; Jiucheng He; Thomas W. Axelrad; Haydee E. P. Bazan
Tags: cornea, furin, gelatinase a, myofibroblasts, proteins
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 487-496. doi:https://doi.org/10.1167/iovs.04-0852
Characterization and Distribution of Bone Marrow–Derived Cells in Mouse Cornea Free
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Takahiro Nakamura; Fumihiko Ishikawa; Koh-hei Sonoda; Toshio Hisatomi; Hong Qiao; Jun Yamada; Mitsuhiro Fukata; Tatsuro Ishibashi; Mine Harada; Shigeru Kinoshita
Tags: bone marrow, cornea, mice
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 497-503. doi:https://doi.org/10.1167/iovs.04-1154
Expression of Muscarinic and Adrenergic Receptors in Normal Human Conjunctival Epithelium Free
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Amalia Enríquez de Salamanca; Karyn F. Siemasko; Yolanda Diebold; Margarita Calonge; Jianping Gao; Mónica Juárez-Campo; Michael E. Stern
Tags: adrenergic receptor, cell lines, conjunctiva, conjunctival epithelium, cytokine
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 504-513. doi:https://doi.org/10.1167/iovs.04-0665

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Reduced Visual Function Associated with Infantile Spasms in Children on Vigabatrin Therapy Free
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Dena S. Hammoudi; Sophia S. F. Lee; Adena Madison; Giuseppe Mirabella; J. Raymond Buncic; William J. Logan; O. Carter Snead; Carol A. Westall
Tags: child, infantile spasms, seizures, vigabatrin, vision
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 514-520. doi:https://doi.org/10.1167/iovs.04-0559
The Critical Period for Susceptibility of Human Stereopsis Free
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Sherry L. Fawcett; Yi-Zhong Wang; Eileen E. Birch
Tags: critical period (psychology), depth perception, disease susceptibility
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 521-525. doi:https://doi.org/10.1167/iovs.04-0175
Risk Factors for Accommodative Esotropia among Hypermetropic Children Free
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Eileen E. Birch; Sherry L. Fawcett; Sarah E. Morale; David R. Weakley, Jr; Dianna Hughbanks Wheaton
Tags: child, esotropia, accommodative, hyperopia, medical history, risk factors
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 526-529. doi:https://doi.org/10.1167/iovs.04-0618
Magnetic Resonance Imaging Evidence For Widespread Orbital Dysinnervation in Congenital Fibrosis of Extraocular Muscles Due to Mutations in KIF21A Free
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Joseph L. Demer; Robert A. Clark; Elizabeth C. Engle
Tags: magnetic resonance imaging, mutation, diagnostic imaging, congenital fibrosis of the extraocular muscles, eye
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 530-539. doi:https://doi.org/10.1167/iovs.04-1125

Glaucoma

Viscoelastic Material Properties of the Peripapillary Sclera in Normal and Early-Glaucoma Monkey Eyes Free
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J. Crawford Downs; J-K. Francis Suh; Kevin A. Thomas; Anthony J. Bellezza; Richard T. Hart; Claude F. Burgoyne
Tags: cercopithecidae, eye, glaucoma, sclera, stress
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 540-546. doi:https://doi.org/10.1167/iovs.04-0114
Glaucomatous Visual Field Progression with Frequency-Doubling Technology and Standard Automated Perimetry in a Longitudinal Prospective Study Free
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Sharon A. Haymes; Donna M. Hutchison; Terry A. McCormick; Devesh K. Varma; Marcelo T. Nicolela; Raymond P. LeBlanc; Balwantray C. Chauhan
Tags: glaucoma, perimetry, prospective studies, technology, visual fields
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 547-554. doi:https://doi.org/10.1167/iovs.04-0973
A Genetic Contribution to Intraocular Pressure: The Beaver Dam Eye Study Free
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Priya Duggal; Alison P. Klein; Kristine E. Lee; Sudha K. Iyengar; Ronald Klein; Joan E. Bailey-Wilson; Barbara E. K. Klein
Tags: eye, genetic linkage analysis, genetics, intraocular pressure, segregation analysis
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 555-560. doi:https://doi.org/10.1167/iovs.04-0729
Relative Change in Diurnal Mean Ocular Perfusion Pressure: A Risk Factor for the Diagnosis of Primary Open-Angle Glaucoma Free
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Mitra Sehi; John G. Flanagan; Leilei Zeng; Richard J. Cook; Graham E. Trope
Tags: intraocular pressure, mopp protocol, open-angle glaucoma, perfusion, risk factors
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 561-567. doi:https://doi.org/10.1167/iovs.04-1033
Transforming Growth Factor-β2 Modulated Extracellular Matrix Component Expression in Cultured Human Optic Nerve Head Astrocytes Free
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Rudolf Fuchshofer; Marco Birke; Ulrich Welge-Lussen; Daniel Kook; Elke Lütjen-Drecoll
Tags: astrocytes, connective tissue growth factor, extracellular matrix, optic disk, western blotting
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 568-578. doi:https://doi.org/10.1167/iovs.04-0649

Immunology and Microbiology

Spontaneous Ocular Surface Inflammation and Goblet Cell Disappearance in IκBζ Gene-Disrupted Mice Free
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Mayumi Ueta; Junji Hamuro; Masahiro Yamamoto; Kazuhiro Kaseda; Shizuo Akira; Shigeru Kinoshita
Tags: genes, goblet cells, inflammation, mice, conjunctiva
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 579-588. doi:https://doi.org/10.1167/iovs.04-1055
Activation of Toll-Like Receptor (TLR)2, TLR4, and TLR9 in the Mammalian Cornea Induces MyD88-Dependent Corneal Inflammation Free
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Angela C. Johnson; Fred P. Heinzel; Eugenia Diaconu; Yan Sun; Amy G. Hise; Douglas Golenbock; Jonathan H. Lass; Eric Pearlman
Tags: cornea, corneal stroma, keratitis, mice, myd88 gene
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 589-595. doi:https://doi.org/10.1167/iovs.04-1077
Anti-CD137 mAb Treatment Inhibits Experimental Autoimmune Uveitis by Limiting Expansion and Increasing Apoptotic Death of Uveitogenic T Cells Free
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Hui Shao; Yangxin Fu; Tianjiang Liao; Young Peng; Lieping Chen; Henry J. Kaplan; Deming Sun
Tags: monoclonal antibodies, t-lymphocytes, uveitis, autoimmune diseases, mice
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 596-603. doi:https://doi.org/10.1167/iovs.04-0835
Ocular Virulence of Capsule-Deficient Streptococcus pneumoniae in a Rabbit Keratitis Model Free
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Julian M. Reed; Richard J. O’Callaghan; Dalia O. Girgis; Clare C. McCormick; Armando R. Caballero; Mary E. Marquart
Tags: cornea, infections, keratitis, oryctolagus cuniculus, streptococcus pneumoniae
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 604-608. doi:https://doi.org/10.1167/iovs.04-0889

Lens

Comparisons between Pharmacologically and Edinger-Westphal–Stimulated Accommodation in Rhesus Monkeys Free
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Lisa A. Ostrin; Adrian Glasser
Tags: biometry, lens, crystalline, macaca mulatta, visual accommodation, lens (device)
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 609-617. doi:https://doi.org/10.1167/iovs.04-0990
The Influence of SRC-Family Tyrosine Kinases on Na,K-ATPase Activity in Lens Epithelium Free
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Larry D. Bozulic; William L. Dean; Nicholas A. Delamere
Tags: adenosine triphosphatases, lens epithelium, src-family kinases, phosphotransferases, protein tyrosine kinase
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 618-622. doi:https://doi.org/10.1167/iovs.04-0809
A New Locus for Autosomal Recessive Nuclear Cataract Mapped to Chromosome 19q13 in a Pakistani Family Free
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S. Amer Riazuddin; Afshan Yasmeen; Qingjiong Zhang; Wenliang Yao; Muhammad Farooq Sabar; Zahoor Ahmed; Sheikh Riazuddin; J. Fielding Hejtmancik
Tags: autosomal recessive inheritance, cataract, nuclear, chromosomes, family, cataract
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 623-626. doi:https://doi.org/10.1167/iovs.04-0955
Phosphorylation and Glycosylation of Bovine Lens MP20 Free
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Lisa A. Ervin; Lauren E. Ball; Rosalie K. Crouch; Kevin L. Schey
Tags: cattle, cyanogen bromide, glycosylation, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 627-635. doi:https://doi.org/10.1167/iovs.04-0894

Physiology and Pharmacology

Comparison of the Autoregulatory Mechanisms between Middle Cerebral Artery and Ophthalmic Artery after Thigh Cuff Deflation in Healthy Subjects Free
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Julia Kolodjaschna; Fatmire Berisha; Solveig Lung; Heinrich Schima; Elzbieta Polska; Leopold Schmetterer
Tags: catheter cuffs, middle cerebral artery, ophthalmic artery, thigh, blood pressure
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 636-640. doi:https://doi.org/10.1167/iovs.04-0717
Permeability of Retinal Pigment Epithelium: Effects of Permeant Molecular Weight and Lipophilicity Free
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Leena Pitkänen; Veli-Pekka Ranta; Hanna Moilanen; Arto Urtti
Tags: lipophilicity, molecular mass, permeability, retinal pigment epithelium, choroid
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 641-646. doi:https://doi.org/10.1167/iovs.04-1051
Secretoneurin in the Peripheral Ocular Innervation Free
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Josef Troger; Alfred Doblinger; Johannes Leierer; Andrea Laslop; Eduard Schmid; Barbara Teuchner; Markus Opatril; Wolfgang Philipp; Lars Klimaschewski; Kristian Pfaller; Wolfgang Göttinger; Reiner Fischer-Colbrie
Tags: body tissue, capsaicin, eye, mass or substance concentration per volume, nerve supply
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 647-654. doi:https://doi.org/10.1167/iovs.04-0425
Preclinical Evaluation of a Novel Episcleral Cyclosporine Implant for Ocular Graft-Versus-Host Disease Free
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Hyuncheol Kim; Karl G. Csaky; Brian C. Gilger; James P. Dunn; Susan S. Lee; Marcus Tremblay; Francisco de Monasterio; Ginger Tansey; Peng Yuan; Peter M. Bungay; Robert J. Lutz; Michael R. Robinson
Tags: cyclosporine, graft-versus-host disease, implants, oryctolagus cuniculus
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 655-662. doi:https://doi.org/10.1167/iovs.04-1076

Retina

A Novel Mutation of COL2A1 Resulting in Dominantly Inherited Rhegmatogenous Retinal Detachment Free
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Allan J. Richards; Sarah Meredith; Arabella Poulson; Philip Bearcroft; Graeme Crossland; David M. Baguley; John D. Scott; Martin P. Snead
Tags: family, mutation, rhegmatogenous retinal detachment, stickler syndrome, phenotype
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 663-668. doi:https://doi.org/10.1167/iovs.04-1017
Role of Neurotrophin-4/5 in Neural Cell Death during Retinal Development and Ischemic Retinal Injury In Vivo Free
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Chikako Harada; Takayuki Harada; Hun-Meng A. Quah; Kazuhiko Namekata; Kazuhiko Yoshida; Shigeaki Ohno; Kohichi Tanaka; Luis F. Parada
Tags: ischemia, neurons, retinal injuries, ntf5 gene, mice
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 669-673. doi:https://doi.org/10.1167/iovs.04-0826
Neuroprotective Effect of Subretinal Implants in the RCS Rat Free
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Machelle T. Pardue; Michael J. Phillips; Hang Yin; Brian D. Sippy; Sarah Webb-Wood; Alan Y. Chow; Sherry L. Ball
Tags: eye, implants, surgical procedures, operative, neuroprotective effect, photoreceptors
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 674-682. doi:https://doi.org/10.1167/iovs.04-0515
Early-Onset Macular Degeneration with Drusen in a Cynomolgus Monkey (Macaca fascicularis) Pedigree: Exclusion of 13 Candidate Genes and Loci Free
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Shinsuke Umeda; Radha Ayyagari; Rando Allikmets; Michihiro T. Suzuki; Athancios J. Karoukis; Rajesh Ambasudhan; Jana Zernant; Haru Okamoto; Fumiko Ono; Keiji Terao; Atsushi Mizota; Yasuhiro Yoshikawa; Yasuhiko Tanaka; Takeshi Iwata
Tags: candidate disease gene, cercopithecidae, drusen, genes, genetic pedigree
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 683-691. doi:https://doi.org/10.1167/iovs.04-1031
Nutritional Manipulation of Primate Retinas, III: Effects of Lutein or Zeaxanthin Supplementation on Adipose Tissue and Retina of Xanthophyll-Free Monkeys Free
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Elizabeth J. Johnson; Martha Neuringer; Robert M. Russell; Wolfgang Schalch; D. Max Snodderly
Tags: adipose tissue, cercopithecidae, lutein, retina, diet
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 692-702. doi:https://doi.org/10.1167/iovs.02-1192
Effect of Benzalkonium Chloride on Transscleral Drug Delivery Free
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Komei Okabe; Hideya Kimura; Junko Okabe; Aki Kato; Hideo Shimizu; Takashi Ueda; Shouichi Shimada; Yuichiro Ogura
Tags: benzalkonium chloride, drug delivery systems, osmotic pump system, permeability, retina
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 703-708. doi:https://doi.org/10.1167/iovs.03-0934
Retinal Artery and Vein Diameters during Pregnancy in Diabetic Women Free
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Michael Larsen; Lotte Berdiin Colmorn; Marie Bønnelycke; Risto Kaaja; Ilkka Immonen; Birgit Sander; Sirpa Loukovaara
Tags: central retinal artery, diabetes mellitus, diameter, pregnancy in diabetics, pregnancy trimester, third
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 709-713. doi:https://doi.org/10.1167/iovs.04-0604
RPE Damage Thresholds and Mechanisms for Laser Exposure in the Microsecond-to-Millisecond Time Regimen Free
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Georg Schuele; Marco Rumohr; Gereon Huettmann; Ralf Brinkmann
Tags: acoustics, lasers, microbubbles, retinal pigment cell
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 714-719. doi:https://doi.org/10.1167/iovs.04-0136
Relationship between the Parameters of Retinal Circulation Measured by Laser Doppler Velocimetry and a Marker of Early Systemic Atherosclerosis Free
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Taiji Nagaoka; Yoshinao Ishii; Toshiharu Takeuchi; Atsushi Takahashi; Eiichi Sato; Akitoshi Yoshida
Tags: atherosclerosis, retina circulation, velocimetry, laser-doppler, common carotid artery
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 720-725. doi:https://doi.org/10.1167/iovs.04-0906
Preclinical Pharmacokinetics of Ranibizumab (rhuFabV2) after a Single Intravitreal Administration Free
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Jacques Gaudreault; David Fei; Jeriza Rusit; Pamela Suboc; Vanessa Shiu
Tags: ranibizumab, pharmacokinetics, intravitreal injections
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 726-733. doi:https://doi.org/10.1167/iovs.04-0601
Disease Expression in Usher Syndrome Caused by VLGR1 Gene Mutation (USH2C) and Comparison with USH2A Phenotype Free
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Sharon B. Schwartz; Tomas S. Aleman; Artur V. Cideciyan; Elizabeth A. M. Windsor; Alexander Sumaroka; Alejandro J. Roman; Tej Rane; Elaine E. Smilko; Jean Bennett; Edwin M. Stone; William J. Kimberling; Xue-Zhong Liu; Samuel G. Jacobson
Tags: cysts, family, mutation, phenotype, usher syndrome
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 734-743. doi:https://doi.org/10.1167/iovs.04-1136

Retinal Cell Biology

Sympathetic Innervation Regulates Basement Membrane Thickening and Pericyte Number in Rat Retina Free
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Luke A. Wiley; Gerald R. Rupp; Jena J. Steinle
Tags: basement membrane, fibronectins, laminin, nerve supply, pericytes
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 744-748. doi:https://doi.org/10.1167/iovs.04-1023
The Molecular Basis of Oxidative Stress-Induced Cell Death in an Immortalized Retinal Ganglion Cell Line Free
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Pamela Maher; Anne Hanneken
Tags: cell death, glutamate, glutamates, retinal ganglion cells, stress
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 749-757. doi:https://doi.org/10.1167/iovs.04-0883

Visual Psychophysics and Physiological Optics

A Psychophysical Investigation of Ocular Expansion in Human Eyes Free
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Fuensanta A. Vera-Diaz; Paul V. McGraw; Niall C. Strang; David Whitaker
Tags: eye, psychophysics, visual fields, perception
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 758-763. doi:https://doi.org/10.1167/iovs.04-0127
Recovery of the Rod Photoresponse in Infants Free
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Ronald M. Hansen; Anne B. Fulton
Tags: infant, recovery of function, rod photoreceptors, phototransduction, adult
Investigative Ophthalmology & Visual Science February 2005, Vol.46, 764-768. doi:https://doi.org/10.1167/iovs.04-0257

Erratum

Erratum Free
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Investigative Ophthalmology & Visual Science February 2005, Vol.46, 414. doi:
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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