Volume 47 Issue 6 | IOVS

Anatomy and Pathology/Oncology

Three-Dimensional Modeling of the Human Eye Based on Magnetic Resonance Imaging Free

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Krish D. Singh; Nicola S. Logan; Bernard Gilmartin

Tags: eye, magnetic resonance imaging, myopia

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2272-2279. doi:https://doi.org/10.1167/iovs.05-0856

Biochemistry and Molecular Biology

The Proteome of Central and Peripheral Retina with Progression of Age-Related Macular Degeneration Free

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Cheryl M. Ethen; Cavan Reilly; Xiao Feng; Timothy W. Olsen; Deborah A. Ferrington

Tags: age-related macular degeneration, gel, proteins, proteome, retina

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2280-2290. doi:https://doi.org/10.1167/iovs.05-1395

Family-Based Association Analysis of Hepatocyte Growth Factor (HGF) Gene Polymorphisms in High Myopia Free

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Wei Han; Maurice K. H. Yap; Jing Wang; Shea Ping Yip

Tags: family, genes, myopia, single nucleotide polymorphism, hepatocyte growth factor

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2291-2299. doi:https://doi.org/10.1167/iovs.05-1344

Arpc1b Gene Is a Candidate Prediction Marker for Choroidal Malignant Melanomas Sensitive to Radiotherapy Free

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Ken Kumagai; Yoshinori Nimura; Atsushi Mizota; Nobuyuki Miyahara; Mizuho Aoki; Yoshiya Furusawa; Masaki Takiguchi; Shuichi Yamamoto; Naohiko Seki

Tags: cell lines, genes, malignant melanoma of choroid, radiation therapy, radiation tolerance

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2300-2304. doi:https://doi.org/10.1167/iovs.05-0810

Defining the Human Macula Transcriptome and Candidate Retinal Disease Genes Using EyeSAGE Free

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Catherine Bowes Rickman; Jessica N. Ebright; Zachary J. Zavodni; Ling Yu; Tianyuan Wang; Stephen P. Daiger; Graeme Wistow; Kathy Boon; Michael A. Hauser

Tags: genes, libraries, macula densa, macula lutea, retina

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2305-2316. doi:https://doi.org/10.1167/iovs.05-1437

Clinical and Epidemiologic Research

The Quality of Reporting of Diagnostic Accuracy Studies in Glaucoma Using the Heidelberg Retina Tomograph Free

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Manoharan Shunmugam; Augusto Azuara-Blanco

Tags: glaucoma, heidelberg retina tomograph

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2317-2323. doi:https://doi.org/10.1167/iovs.05-1250

A Population-Based Assessment of Presbyopia in the State of Andhra Pradesh, South India: The Andhra Pradesh Eye Disease Study Free

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Praveen K. Nirmalan; Sannapaneni Krishnaiah; Bindiganavale R. Shamanna; Gullapalli N. Rao; Ravi Thomas

Tags: eye diseases, india, presbyopia

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2324-2328. doi:https://doi.org/10.1167/iovs.05-1192

Plasma Lutein and Zeaxanthin and Other Carotenoids as Modifiable Risk Factors for Age-Related Maculopathy and Cataract: The POLA Study Free

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Cécile Delcourt; Isabelle Carrière; Martine Delage; Pascale Barberger-Gateau; Wolfgang Schalch; the POLA Study Group

Tags: age-related macular degeneration, carotenoids, cataract, lutein, plasma

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2329-2335. doi:https://doi.org/10.1167/iovs.05-1235

A Prospective Assessment of the Y402H Variant in Complement Factor H, Genetic Variants in C-Reactive Protein, and Risk of Age-Related Macular Degeneration Free

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Debra A. Schaumberg; William G. Christen; Piotr Kozlowski; David T. Miller; Paul M. Ridker; Robert Y. L. Zee

Tags: age-related macular degeneration, complement factor h, c-reactive protein, genetics

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2336-2340. doi:https://doi.org/10.1167/iovs.05-1456

Retinal Vascular Caliber, Cardiovascular Risk Factors, and Inflammation: The Multi-Ethnic Study of Atherosclerosis (MESA) Free

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Tien Yin Wong; F. M. Amirul Islam; Ronald Klein; Barbara E. K. Klein; Mary Frances Cotch; Cecilia Castro; A. Richey Sharrett; Eyal Shahar

Tags: diameter, heart disease risk factors, inflammation, multi-ethnic study of atherosclerosis, retinal vascular caliber

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2341-2350. doi:https://doi.org/10.1167/iovs.05-1539

Distribution of Macular Thickness by Optical Coherence Tomography: Findings from a Population-Based Study of 6-Year-Old Children Free

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Son C. Huynh; Xiu Ying Wang; Elena Rochtchina; Paul Mitchell

Tags: child, macula densa, macula lutea, optical coherence tomography, ethnic group

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2351-2357. doi:https://doi.org/10.1167/iovs.05-1396

Cornea

Cross-talk among Rho GTPases Acting Downstream of PI 3-Kinase Induces Mesenchymal Transformation of Corneal Endothelial Cells Mediated by FGF-2 Free

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Jeong Goo Lee; EunDuck P. Kay

Tags: 1-phosphatidylinositol 3-kinase, actins, cdc42 gtp-binding protein, chronic exertional compartment syndrome, fibroblast growth factor 2

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2358-2368. doi:https://doi.org/10.1167/iovs.05-1490

Multifunctional Roles of Human Cathelicidin (LL-37) at the Ocular Surface Free

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Ling C. Huang; Tihomira D. Petkova; Rose Y. Reins; Rita J. Proske; Alison M. McDermott

Tags: ll-37 peptide

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2369-2380. doi:https://doi.org/10.1167/iovs.05-1649

Basement Membrane Dissolution and Reassembly by Limbal Corneal Epithelial Cells Expanded on Amniotic Membrane Free

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Wei Li; Hua He; Ching-Liang Kuo; Yingying Gao; Tetsuya Kawakita; Scheffer C. G. Tseng

Tags: amnion, basement membrane, corneal epithelial cells, culture media, conditioned, dissolution

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2381-2389. doi:https://doi.org/10.1167/iovs.05-1491

Keratan Sulfate and Chondroitin/Dermatan Sulfate in Maximally Recovered Hypocellular Stromal Interface Scars of Postmortem Human LASIK Corneas Free

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Yuntao Zhang; Ingo Schmack; Daniel G. Dawson; Hans E. Grossniklaus; Abigail H. Conrad; Yutaka Kariya; Kiyoshi Suzuki; Henry F. Edelhauser; Gary W. Conrad

Tags: autopsy, chondroitin, cicatrix, cornea, dermatan sulfate

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2390-2396. doi:https://doi.org/10.1167/iovs.05-1559

Pax6 Overexpression Suppresses Cell Proliferation and Retards the Cell Cycle in Corneal Epithelial Cells Free

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Jie Ouyang; Ying-Cheng Shen; Lung-Kun Yeh; Wei Li; Brad M. Coyle; Chia-Yang Liu; M. Elizabeth Fini

Tags: cell proliferation, cells, corneal epithelial cells, protein overexpression, proteins

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2397-2407. doi:https://doi.org/10.1167/iovs.05-1083

Antibody Blockade of Junctional Adhesion Molecule-A in Rabbit Corneal Endothelial Tight Junctions Produces Corneal Swelling Free

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Kenneth J. Mandell; Glenn P. Holley; Charles A. Parkos; Henry F. Edelhauser

Tags: adhesions, antibodies, cornea, corneal endothelium, edema

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2408-2416. doi:https://doi.org/10.1167/iovs.05-0745

Characterization of Putative Stem Cell Populations in the Cornea Using Synchrotron Infrared Microspectroscopy Free

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Matthew J. German; Hubert M. Pollock; Bojun Zhao; Mark J. Tobin; Azzedine Hammiche; Adam Bentley; Leanne J. Cooper; Francis L. Martin; Nigel J. Fullwood

Tags: cornea, spinal cord stimulation, stem cells, synchrotrons, spectroscopy, fourier transform infrared

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2417-2421. doi:https://doi.org/10.1167/iovs.05-1254

Effect of CTCF-Binding Motif on Regulation of PAX6 Transcription Free

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Dan Wu; Tie Li; Zhenyu Lu; Wei Dai; Ming Xu; Luo Lu

Tags: dna, mutation, regulation, ultraviolet rays, western blotting

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2422-2429. doi:https://doi.org/10.1167/iovs.05-0536

UVB-Mediated Induction of Cytokines and Growth Factors in Pterygium Epithelial Cells Involves Cell Surface Receptors and Intracellular Signaling Free

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Nick Di Girolamo; Denis Wakefield; Minas T. Coroneo

Tags: cytokine, epithelial cells, growth factor, interleukin-6, interleukin-8

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2430-2437. doi:https://doi.org/10.1167/iovs.05-1130

Corneal Epitheliotrophic Capacity of Three Different Blood-Derived Preparations Free

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Lei Liu; Dirk Hartwig; Susanne Harloff; Philip Herminghaus; Thilo Wedel; Karsten Kasper; Gerd Geerling

Tags: blood platelets, cornea, corneal epithelial cells, fresh-frozen plasma, mass or substance concentration per volume

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2438-2444. doi:https://doi.org/10.1167/iovs.05-0876

Conjunctival Cytokine Expression in Symptomatic Moderate Dry Eye Subjects Free

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Srihari Narayanan; William L. Miller; Alison M. McDermott

Tags: conjunctiva, cytokine, dry eye syndromes

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2445-2450. doi:https://doi.org/10.1167/iovs.05-1364

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Combined Gaze-Angle and Vergence Variation in Infantile Nystagmus: Two Therapies That Improve the High-Visual-Acuity Field and Methods to Measure It Free

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Alessandro Serra; Louis F. Dell’Osso; Jonathan B. Jacobs; Robert A. Burnstine

Tags: gaze, hysteresis, pathologic nystagmus, visual acuity, surgical procedures, operative

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2451-2460. doi:https://doi.org/10.1167/iovs.05-1320

Increased Extraocular Muscle Strength with Direct Injection of Insulin-like Growth Factor-I Free

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Brian C. Anderson; Stephen P. Christiansen; Steven Grandt; Robert W. Grange; Linda K. McLoon

Tags: insulin-like growth factor i, muscle, muscle of orbit, superior rectus muscle

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2461-2467. doi:https://doi.org/10.1167/iovs.05-1416

Brief Daily Periods of Unrestricted Vision Can Prevent Form-Deprivation Amblyopia Free

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Janice M. Wensveen; Ronald S. Harwerth; Li-Fang Hung; Ramkumar Ramamirtham; Chea-su Kee; Earl L. Smith, III

Tags: amblyopia, cercopithecidae, contrast sensitivity, eye, vision

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2468-2477. doi:https://doi.org/10.1167/iovs.05-0885

Horizontal Saccade Dynamics across the Human Life Span Free

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Elizabeth L. Irving; Martin J. Steinbach; Linda Lillakas; Raiju J. Babu; Natalie Hutchings

Tags: life span, saccades, velocity, child

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2478-2484. doi:https://doi.org/10.1167/iovs.05-1311

Polytetrafluoroethylene/Polylactide-co-Glycolide Laminate Containing Dexamethasone Allows Delayed Adjustable Strabismus Surgery in a Rabbit Model Free

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Jun-Pil Jee; Ho-Kyung Choung; Chong-Kook Kim; Jeong-Min Hwang

Tags: adhesions, dexamethasone, oryctolagus cuniculus, polylactide, polytetrafluoroethylene

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2485-2490. doi:https://doi.org/10.1167/iovs.05-0796

Glaucoma

Experimental Glaucoma and Optic Nerve Transection Induce Simultaneous Upregulation of Proapoptotic and Prosurvival Genes Free

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Hani Levkovitch-Verbin; Rima Dardik; Shelly Vander; Yael Nisgav; Maya Kalev-Landoy; Shlomo Melamed

Tags: genes, glaucoma, optic nerve, up-regulation (physiology)

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2491-2497. doi:https://doi.org/10.1167/iovs.05-0996

Investigating the Effect of Ciliary Body Photodynamic Therapy in a Glaucoma Mouse Model Free

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Akihisa Matsubara; Toru Nakazawa; Deeba Husain; Eirini Iliaki; Edward Connolly; Norman A. Michaud; Evangelos S. Gragoudas; Joan W. Miller

Tags: ciliary body, eye, glaucoma, mice, photochemotherapy

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2498-2507. doi:https://doi.org/10.1167/iovs.05-0959

Proteomics Implicates Peptidyl Arginine Deiminase 2 and Optic Nerve Citrullination in Glaucoma Pathogenesis Free

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Sanjoy K. Bhattacharya; John S. Crabb; Vera L. Bonilha; Xiaorong Gu; Hidenari Takahara; John W. Crabb

Tags: arginine, glaucoma, optic nerve, proteins, pathogenesis

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2508-2514. doi:https://doi.org/10.1167/iovs.05-1499

Methylcellulose, a Healing Inhibitor Factor in an Animal Model of Trabeculectomy Free

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Ayman A. M. Shouman; Ahmed Helal; Mohamed A. Marzouk; Eman M. A. Zaki

Tags: animal model, healing process, methylcellulose, trabeculectomy, wound healing

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2515-2519. doi:https://doi.org/10.1167/iovs.05-1147

A Statistical Approach to the Evaluation of Covariate Effects on the Receiver Operating Characteristic Curves of Diagnostic Tests in Glaucoma Free

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Felipe A. Medeiros; Pamela A. Sample; Linda M. Zangwill; Jeffrey M. Liebmann; Christopher A. Girkin; Robert N. Weinreb

Tags: diagnostic techniques and procedures, glaucoma, severity of illness, roc curve

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2520-2527. doi:https://doi.org/10.1167/iovs.05-1441

Altered Endothelin-1 Vasoreactivity in Patients with Untreated Normal-Pressure Glaucoma Free

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Emer Henry; David E. Newby; David J. Webb; Patrick W. F. Hadoke; Colm J. O’Brien

Tags: endothelin-1, glaucoma, did not receive therapy or drug

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2528-2532. doi:https://doi.org/10.1167/iovs.05-0240

Mitochondrial Abnormalities in Patients with Primary Open-Angle Glaucoma Free

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Khaled K. Abu-Amero; Jose Morales; Thomas M. Bosley

Tags: dna, mitochondrial, mitochondria, open-angle glaucoma, sequence analysis, optn gene

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2533-2541. doi:https://doi.org/10.1167/iovs.05-1639

Distribution of WDR36 DNA Sequence Variants in Patients with Primary Open-Angle Glaucoma Free

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Michael A. Hauser; R. Rand Allingham; Kevin Linkroum; Jun Wang; Karen LaRocque-Abramson; Dayse Figueiredo; Cecilia Santiago-Turla; Elizabeth A. del Bono; Jonathan L. Haines; Margaret A. Pericak-Vance; Janey L. Wiggs

Tags: dna, open-angle glaucoma, wdr36 gene

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2542-2546. doi:https://doi.org/10.1167/iovs.05-1476

Immunology and Microbiology

Ocular Infiltrating CD4⁺ T Cells from Patients with Vogt-Koyanagi-Harada Disease Recognize Human Melanocyte Antigens Free

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Sunao Sugita; Hiroshi Takase; Chikako Taguchi; Yasuhisa Imai; Koju Kamoi; Tatsushi Kawaguchi; Yoshiharu Sugamoto; Yuri Futagami; Kyogo Itoh; Manabu Mochizuki

Tags: antigens, catechol oxidase, melanocytes, monophenol monooxygenase, peptides

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2547-2554. doi:https://doi.org/10.1167/iovs.05-1547

Treatment of Autoimmune Anterior Uveitis with Recombinant TCR Ligands Free

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Grazyna Adamus; Gregory G. Burrows; Arthur A. Vandenbark; Halina Offner

Tags: autoimmune diseases, autoimmunity, eye, ligands, peptides

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2555-2561. doi:https://doi.org/10.1167/iovs.05-1242

Inhibitory Effects of Lutein on Endotoxin-Induced Uveitis in Lewis Rats Free

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Xue-Hai Jin; Kazuhiro Ohgami; Kenji Shiratori; Yukari Suzuki; Takeshi Hirano; Yoshikazu Koyama; Kazuhiko Yoshida; Iliyana Ilieva; Ken Iseki; Shigeaki Ohno

Tags: lutein, rats, uveitis, aqueous humor, endotoxins

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2562-2568. doi:https://doi.org/10.1167/iovs.05-1429

Lens

Ubiquitin–Proteasome Pathway Function Is Required for Lens Cell Proliferation and Differentiation Free

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Weimin Guo; Fu Shang; Qing Liu; Lyudmila Urim; Minlei Zhang; Allen Taylor

Tags: crystallins, fibroblast growth factor 2, lens (device), lens cell, lens, crystalline

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2569-2575. doi:https://doi.org/10.1167/iovs.05-0261

Physiology and Pharmacology

Swelling-Activated Cl⁻ Channels Support Cl⁻ Secretion by Bovine Ciliary Epithelium Free

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Chi Wai Do; Kim Peterson-Yantorno; Mortimer M. Civan

Tags: bodily secretions, cattle, ciliary epithelium, edema, hypotonicity

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2576-2582. doi:https://doi.org/10.1167/iovs.05-0851

A New Method for Measuring Free Drug Concentration: Retinal Tissue as a Biosensor Free

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Soile Nymark; Charlotte Haldin; Heikki Tenhu; Ari Koskelainen

Tags: 1-methyl-3-isobutylxanthine, body tissue, free drug fraction, mass or substance concentration per volume, rod photoreceptors

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2583-2588. doi:https://doi.org/10.1167/iovs.05-1116

Selective Cell Uptake of Modified Tat Peptide–Fluorophore Conjugates in Rat Retina in Ex Vivo and In Vivo Models Free

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Edward M. Barnett; Boobalan Elangovan; Kristin E. Bullok; David Piwnica-Worms

Tags: peptides, retina, intravitreal injections

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2589-2595. doi:https://doi.org/10.1167/iovs.05-1470

A Novel Bioerodible Deep Scleral Lamellar Cyclosporine Implant for Uveitis Free

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Brian C. Gilger; Jacklyn H. Salmon; David A. Wilkie; Lars P. J. Cruysberg; Jonghyeon Kim; Matt Hayat; Hyuncheol Kim; Stephanie Kim; Peng Yuan; Susan S. Lee; Susan M. Harrington; Patrick R. Murray; Henry F. Edelhauser; Karl G. Csaky; Michael R. Robinson

Tags: cyclosporine, implants, sclera, uveitis

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2596-2605. doi:https://doi.org/10.1167/iovs.05-1540

Retina

Inner Retinal Mechanisms Engaged by Retinal Electrical Stimulation Free

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Eyal Margalit; Wallace B. Thoreson

Tags: electric stimulation, ganglia, retinal bipolar cells, gamma-aminobutyric acid, picrotoxin

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2606-2612. doi:https://doi.org/10.1167/iovs.05-1093

Retinal Light Damage: Structural and Functional Effects of the Antioxidant Glutathione Peroxidase-1 Free

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Andrew D. Gosbell; Nada Stefanovic; Lyndee L. Scurr; Josefa Pete; Ismail Kola; Ian Favilla; Judy B. de Haan

Tags: antioxidants, glutathione, mice, peroxidase, retina

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2613-2622. doi:https://doi.org/10.1167/iovs.05-0962

Dose-Dependent Effect of Pitavastatin on VEGF and Angiogenesis in a Mouse Model of Choroidal Neovascularization Free

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Hadi J. Zambarakji; Toru Nakazawa; Edward Connolly; Anne Marie Lane; Sreedevi Mallemadugula; Michael Kaplan; Norman Michaud; Ali Hafezi-Moghadam; Evangelos S. Gragoudas; Joan W. Miller

Tags: choroidal neovascularization, mice, pitavastatin, vascular endothelial growth factor a, angiogenesis

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2623-2631. doi:https://doi.org/10.1167/iovs.05-0855

Development and Characterization of a Normalized Canine Retinal cDNA Library for Genomic and Expression Studies Free

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Barbara Zangerl; Qi Sun; Jarek Pillardy; Jennifer L. Johnson; Peter A. Schweitzer; Alvaro G. Hernandez; Lei Liu; Gregory M. Acland; Gustavo D. Aguirre

Tags: dna, complementary, dog, domestic, genome, libraries, clone cells

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2632-2638. doi:https://doi.org/10.1167/iovs.05-1463

The Retinal Vasculature and Function of the Neural Retina in a Rat Model of Retinopathy of Prematurity Free

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Kegao Liu; James D. Akula; Christopher Falk; Ronald M. Hansen; Anne B. Fulton

Tags: electroretinography, neural retina, rats, retinal vasculature, retinopathy of prematurity

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2639-2647. doi:https://doi.org/10.1167/iovs.06-0016

Correlation between the Area of Increased Autofluorescence Surrounding Geographic Atrophy and Disease Progression in Patients with AMD Free

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Steffen Schmitz-Valckenberg; Almut Bindewald-Wittich; Joanna Dolar-Szczasny; Jens Dreyhaupt; Sebastian Wolf; Hendrik P. N. Scholl; Frank G. Holz

Tags: atrophy, autofluorescence, disease progression, atrophic condition of skin, eye

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2648-2654. doi:https://doi.org/10.1167/iovs.05-0892

Predictive Value of Fundus Autofluorescence for Development of Geographic Atrophy in Age-Related Macular Degeneration Free

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John Chopin Hwang; Jackie W. K. Chan; Stanley Chang; R. Theodore Smith

Tags: age-related macular degeneration, atrophy, fundus autofluorescence imaging, pixel, predictive value

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2655-2661. doi:https://doi.org/10.1167/iovs.05-1027

A Study of Retinal Penetration of Intravitreal Tenecteplase in Pigs Free

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Anthony S. L. Kwan; Sarojini Vijayasekaran; Ian L. McAllister; Paula K. Yu; Dao-Yi Yu

Tags: eye, fluorescence, retina, suidae, tenecteplase

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2662-2667. doi:https://doi.org/10.1167/iovs.05-1019

Noninvasive and Simultaneous Imaging of Layer-Specific Retinal Functional Adaptation by Manganese-Enhanced MRI Free

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Bruce A. Berkowitz; Robin Roberts; Dennis J. Goebel; Hongmei Luan

Tags: magnetic resonance imaging, manganese, diagnostic imaging, dark adaptation, toxic effect

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2668-2674. doi:https://doi.org/10.1167/iovs.05-1588

Retinal Cell Biology

Cell Phenotype in Normal Epithelial Cell Lines with High Endogenous N-Cadherin: Comparison of RPE to an MDCK Subclone Free

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Yong-Ha Youn; Jeehee Hong; Janice M. Burke

Tags: cadherins, epithelial cells, n-cadherins, phenotype, proteins

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2675-2685. doi:https://doi.org/10.1167/iovs.05-1335

Suppression of Ocular Inflammation in Endotoxin-Induced Uveitis by Inhibiting Nonproteolytic Activation of Prorenin Free

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Shingo Satofuka; Atsuhiro Ichihara; Norihiro Nagai; Kenji Yamashiro; Takashi Koto; Hajime Shinoda; Kousuke Noda; Yoko Ozawa; Makoto Inoue; Kazuo Tsubota; Fumiaki Suzuki; Yuichi Oike; Susumu Ishida

Tags: endotoxins, eye inflammation, intercellular adhesion molecule 1, interleukin-6, leukocytes

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2686-2692. doi:https://doi.org/10.1167/iovs.05-1458

Deletion of Smooth Muscle α-Actin Alters Blood–Retina Barrier Permeability and Retinal Function Free

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James J. Tomasek; Carol J. Haaksma; Robert J. Schwartz; Duc T. Vuong; Sarah X. Zhang; John D. Ash; Jian-xing Ma; Muayyad R. Al-Ubaidi

Tags: actins, permeability, retina, smooth muscle, pericytes

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2693-2700. doi:https://doi.org/10.1167/iovs.05-1297

Hepatocyte Growth Factor Induces Retinal Vascular Permeability via MAP-Kinase and PI-3 Kinase without Altering Retinal Hemodynamics Free

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Allen C. Clermont; Mark Cahill; Haytham Salti; Susan L. Rook; Christian Rask-Madsen; Lucy Goddard; Jun S. Wong; Dahlia Bursell; Sven E. Bursell; Lloyd Paul Aiello

Tags: 1-phosphatidylinositol 3-kinase, eye, fluorescein, hemodynamics, hepatocyte growth factor

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2701-2708. doi:https://doi.org/10.1167/iovs.05-0071

Increased Glutathione Synthesis through an ARE-Nrf2–Dependent Pathway by Zinc in the RPE: Implication for Protection against Oxidative Stress Free

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Khoi-Nguyen Ha; Yan Chen; Jiyang Cai; Paul Sternberg, Jr

Tags: zinc, glutathione, oxidative stress

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2709-2715. doi:https://doi.org/10.1167/iovs.05-1322

Knock-Down of GFRα4 Expression by RNA Interference Affects the Development of Retinal Cell Types in Three-Dimensional Histiotypic Retinal Spheres Free

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Andrée Rothermel; Katja Volpert; Mirjam Burghardt; Christina Lantzsch; Andrea A. Robitzki; Paul G. Layer

Tags: rna interference, rna, messenger, rna, small interfering, transfection, reverse transcriptase polymerase chain reaction

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2716-2725. doi:https://doi.org/10.1167/iovs.05-1472

Reexamining the Hyperglycemic Pseudohypoxia Hypothesis of Diabetic Oculopathy Free

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Roselie M. H. Diederen; Catherine A. Starnes; Bruce A. Berkowitz; Barry S. Winkler

Tags: diabetes mellitus, eye diseases, glucose, hyperglycemic agents, lactates

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2726-2731. doi:https://doi.org/10.1167/iovs.06-0076

Visual Neuroscience

Study of Rod- and Cone-Driven Oscillatory Potentials in Mice Free

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Bo Lei; Gang Yao; Keqing Zhang; Kurt J. Hofeldt; Bo Chang

Tags: electroretinography, mice, retinal cone, rod photoreceptors, mice, inbred c57bl

Investigative Ophthalmology & Visual Science June 2006, Vol.47, 2732-2738. doi:https://doi.org/10.1167/iovs.05-1461

Visual Psychophysics and Physiological Optics

The Letter Contrast Sensitivity Test: Clinical Evaluation of a New Design Free

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