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Anatomy and Pathology/Oncology

Simultaneous Defocus Integration during Refractive Development Free
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Dennis Y. Tse; Carly S. Lam; Jeremy A. Guggenheim; Chuen Lam; King-kit Li; Quan Liu; Chi-ho To
Tags: lens (device), lens, crystalline, myopia, eye, refractive errors
Investigative Ophthalmology & Visual Science December 2007, Vol.48, 5352-5359. doi:10.1167/iovs.07-0383
Long-term Suppression of Neurodegeneration in Chronic Experimental Optic Neuritis: Antioxidant Gene Therapy Free
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Xiaoping Qi; Liang Sun; Alfred S. Lewin; William W. Hauswirth; John Guy
Tags: adaptive testing, antioxidants, cats, chloramphenicol o-acetyltransferase, computed tomography
Investigative Ophthalmology & Visual Science December 2007, Vol.48, 5360-5370. doi:10.1167/iovs.07-0254
Mechanism of Retinoblastoma Tumor Cell Death after Focal Chemotherapy, Radiation, and Vascular Targeting Therapy in a Mouse Model Free
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Maria-Elena Jockovich; Fernando Suarez; Armando Alegret; Yolanda Piña; Brandy Hayden; Colleen Cebulla; William Feuer; Timothy G. Murray
Tags: chemotherapy regimen, mice, radiation, retinoblastoma, tumor cells
Investigative Ophthalmology & Visual Science December 2007, Vol.48, 5371-5376. doi:10.1167/iovs.07-0708

Biochemistry and Molecular Biology

Somatic Ablation of the Lrat Gene in the Mouse Retinal Pigment Epithelium Drastically Reduces Its Retinoid Storage Free
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Alberto Ruiz; Norbert B. Ghyselinck; Nathan Mata; Steven Nusinowitz; Marcia Lloyd; Christine Dennefeld; Pierre Chambon; Dean Bok
Tags: ablation, body tissue, genes, mice, retinoids
Investigative Ophthalmology & Visual Science December 2007, Vol.48, 5377-5387. doi:10.1167/iovs.07-0673
Novel Retinal and Cone Photoreceptor Transcripts Revealed by Human Macular Expression Profiling Free
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Daniel M. Hornan; Stuart N. Peirson; Alison J. Hardcastle; Robert S. Molday; Michael E. Cheetham; Andrew R. Webster
Tags: gene expression profiling, genes, macula densa, macula lutea, molecular profiling
Investigative Ophthalmology & Visual Science December 2007, Vol.48, 5388-5396. doi:10.1167/iovs.07-0355
Late-Onset Cone Photoreceptor Degeneration Induced by R172W Mutation in Rds and Partial Rescue by Gene Supplementation Free
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Shannon Conley; May Nour; Steven J. Fliesler; Muna I. Naash
Tags: genes, mice, mutation, proteins, retina
Investigative Ophthalmology & Visual Science December 2007, Vol.48, 5397-5407. doi:10.1167/iovs.07-0663
PAX6 P46 Binds Chromosomes in the Pericentromeric Region and Induces a Mitosis Defect When Overexpressed Free
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Raffaella Zaccarini; Fabrice P. Cordelières; Patrick Martin; Simon Saule
Tags: binding (molecular function), chromosomes, mitosis, proteins, dna
Investigative Ophthalmology & Visual Science December 2007, Vol.48, 5408-5419. doi:10.1167/iovs.07-0413
A Key Role for Calpains in Retinal Ganglion Cell Death Free
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Declan P. McKernan; Marc B. Guerin; Colm J. O'Brien; Thomas G. Cotter
Tags: calpain, axotomy, cell death, retinal ganglion cells
Investigative Ophthalmology & Visual Science December 2007, Vol.48, 5420-5430. doi:10.1167/iovs.07-0287
A Common Founder Mutation of CERKL Underlies Autosomal Recessive Retinal Degeneration with Early Macular Involvement among Yemenite Jews Free
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Noa Auslender; Dror Sharon; Anan H. Abbasi; Hanna J. Garzozi; Eyal Banin; Tamar Ben-Yosef
Tags: autosomal recessive inheritance, mutation, retinal degeneration, jews, judaism
Investigative Ophthalmology & Visual Science December 2007, Vol.48, 5431-5438. doi:10.1167/iovs.07-0736
Glaucoma-Associated CYP1B1 Mutations Share Similar Haplotype Backgrounds in POAG and PACG Phenotypes Free
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Subhabrata Chakrabarti; Koilkonda R. Devi; Sreelatha Komatireddy; Kiranpreet Kaur; Rajul S. Parikh; Anil K. Mandal; Garudadri Chandrasekhar; Ravi Thomas
Tags: glaucoma, haplotypes, mutation, open-angle glaucoma, phenotype
Investigative Ophthalmology & Visual Science December 2007, Vol.48, 5439-5444. doi:10.1167/iovs.07-0629
A Novel Form of Transducin-Dependent Retinal Degeneration: Accelerated Retinal Degeneration in the Absence of Rod Transducin Free
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Elliott Brill; Katherine M. Malanson; Roxana A. Radu; Natalia V. Boukharov; Zhongyan Wang; Hae-Yun Chung; Marcia B. Lloyd; Dean Bok; Gabriel H. Travis; Martin Obin; Janis Lem
Tags: mice, retinal degeneration, rhodopsin, tissue degeneration, transducin
Investigative Ophthalmology & Visual Science December 2007, Vol.48, 5445-5453. doi:10.1167/iovs.06-1402

Clinical and Epidemiologic Research

Early Structural Status of the Eyes of Healthy Term Neonates Conceived by In Vitro Fertilization or Conceived Naturally Free
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Ruth Axer-Siegel; Zvi Herscovici; Samuel Davidson; Nehama Linder; Ilana Sherf; Moshe Snir
Tags: eye, fertilization in vitro, newborn, infant, cornea
Investigative Ophthalmology & Visual Science December 2007, Vol.48, 5454-5458. doi:10.1167/iovs.07-0929
Slit Lamp–Simulated Oblique Flashlight Test in the Detection of Narrow Angles in Chinese Eyes: The Liwan Eye Study Free
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Mingguang He; Wenyong Huang; David S. Friedman; Changfan Wu; Yingfeng Zheng; Paul J. Foster
Tags: chinese (other dialects), chinese people, eye, slit lamps, swinging flashlight tests
Investigative Ophthalmology & Visual Science December 2007, Vol.48, 5459-5463. doi:10.1167/iovs.07-0670
Circulating Hematopoietic Stem Cells in Patients with Neovascular Age-Related Macular Degeneration Free
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Yuko Yodoi; Manabu Sasahara; Takanori Kameda; Nagahisa Yoshimura; Atsushi Otani
Tags: choroidal neovascularization, exudative age-related macular degeneration, hematopoietic stem cells, cd34 antigens
Investigative Ophthalmology & Visual Science December 2007, Vol.48, 5464-5472. doi:10.1167/iovs.07-0093

Cornea

New Tools for the Evaluation of Toxic Ocular Surface Changes in the Rat Free
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Aude Pauly; Françoise Brignole-Baudouin; Antoine Labbé; Hong Liang; Jean-Michel Warnet; Christophe Baudouin
Tags: bacterial artificial chromosomes, blood alcohol concentration, bronchioloalveolar carcinoma, conjunctiva, cornea
Investigative Ophthalmology & Visual Science December 2007, Vol.48, 5473-5483. doi:10.1167/iovs.06-0728
Effects of Organ Culture and Optisol-GS Storage on Structural Integrity, Phenotypes, and Apoptosis in Cultured Corneal Epithelium Free
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