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Anatomy and Pathology/Oncology

Phenotypic Characterization of Retinoblastoma for the Presence of Putative Cancer Stem-like Cell Markers by Flow Cytometry Free
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Murali M. S. Balla; Geeta K. Vemuganti; Chitra Kannabiran; Santosh G. Honavar; Ramesh Murthy
Tags: cancer, cd44 antigens, cxcr4 receptors, flow cytometry, homing-associated cell adhesion molecule
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1506-1514. doi:https://doi.org/10.1167/iovs.08-2356
The Aqueous Humor Outflow Pathway of Zebrafish Free
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Matthew P. Gray; Richard S. Smith; Kelly A. Soules; Simon W. M. John; Brian A. Link
Tags: aqueous humor, zebrafish, eye, mammals, body tissue
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1515-1521. doi:https://doi.org/10.1167/iovs.08-3010

Biochemistry and Molecular Biology

Genetic Risk for Primary Open-Angle Glaucoma Determined by LMX1B Haplotypes Free
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Soo Park; Yalda Jamshidi; Daniela Vaideanu; Maria Bitner-Glindzicz; Scott Fraser; Jane C. Sowden
Tags: genetic risk, glaucoma, haplotypes, open-angle glaucoma, raised intraocular pressure
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1522-1530. doi:https://doi.org/10.1167/iovs.08-2483
Localization of a Gene for Keratoconus to a 5.6-Mb Interval on 13q32 Free
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Marzena Gajecka; Uppala Radhakrishna; Daniel Winters; Swapan K. Nath; Malgorzata Rydzanicz; Uppala Ratnamala; Kimberly Ewing; Andrea Molinari; Jose A. Pitarque; Kwanghyuk Lee; Suzanne M. Leal; Bassem A. Bejjani
Tags: family, genes, vif, genome, genotype determination, keratoconus
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1531-1539. doi:https://doi.org/10.1167/iovs.08-2173
Rapid and Sensitive Method for Detection of Y402, H402, I62, and V62 Variants of Complement Factor H in Human Plasma Samples Using Mass Spectrometry Free
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Una Kelly; Catherine Bowes Rickman; Eric A. Postel; Michael A. Hauser; Gregory S. Hageman; Vadim Y. Arshavsky; Nikolai P. Skiba
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1540-1545. doi:https://doi.org/10.1167/iovs.08-2782
High Myopia Is Not Associated with the SNPs in the TGIF, Lumican, TGFB1, and HGF Genes Free
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Panfeng Wang; Shiqiang Li; Xueshan Xiao; Xiaoyun Jia; Xiaodong Jiao; Xiangming Guo; Qingjiong Zhang
Tags: genes, interleukin-10, myopia, single nucleotide polymorphism
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1546-1551. doi:https://doi.org/10.1167/iovs.08-2537
Evaluation of the X-Linked High-Grade Myopia Locus (MYP1) with Cone Dysfunction and Color Vision Deficiencies Free
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Ravikanth Metlapally; Michel Michaelides; Anuradha Bulusu; Yi-Ju Li; Marianne Schwartz; Thomas Rosenberg; David M. Hunt; Anthony T. Moore; Stephan Züchner; Catherine Bowes Rickman; Terri L. Young
Tags: color vision defect, copy number polymorphism, dna, genetic pedigree, myopia
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1552-1558. doi:https://doi.org/10.1167/iovs.08-2455
MicroRNA-34a Inhibits Uveal Melanoma Cell Proliferation and Migration through Downregulation of c-Met Free
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Dongsheng Yan; Xiangtian Zhou; Xiaoyan Chen; Dan-Ning Hu; Xiang Da Dong; Jiao Wang; Fan Lu; LiLi Tu; Jia Qu
Tags: cell proliferation, met gene, micrornas, uveal melanoma, down-regulation
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1559-1565. doi:https://doi.org/10.1167/iovs.08-2681
The Severity of Retinal Degeneration in Rp1h Gene-Targeted Mice Is Dependent on Genetic Background Free
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Qin Liu; Alexei Saveliev; Eric A. Pierce
Tags: genes, genetics, mice, mice, congenic, retinal degeneration
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1566-1574. doi:https://doi.org/10.1167/iovs.08-2776

Clinical and Epidemiologic Research

Circulating Hematopoietic Stem Cells in Patients with Idiopathic Choroidal Neovascularization Free
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Manabu Sasahara; Atsushi Otani; Yuko Yodoi; Nagahisa Yoshimura
Tags: choroidal neovascularization, hematopoietic stem cells
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1575-1579. doi:https://doi.org/10.1167/iovs.08-1900
Effects of Dilation on Electronic-ETDRS Visual Acuity in Diabetic Patients Free
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Jennifer K. Sun; Lloyd Paul Aiello; Margaret Stockman; Jerry D. Cavallerano; Ann Kopple; Sharon Eagan; Haijing Qin; Craig Kollman; Roy W. Beck; Adam R. Glassman
Tags: diabetes mellitus, dilatation, pathologic, visual acuity, eye
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1580-1584. doi:https://doi.org/10.1167/iovs.08-2426
Family Caregiver Social Problem-Solving Abilities and Adjustment to Caring for a Relative with Vision Loss Free
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Jennifer K. Bambara; Cynthia Owsley; Virginia Wadley; Roy Martin; Chebon Porter; Laura E. Dreer
Tags: blindness, caregivers, depressive disorders, family caregivers, problem solving
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1585-1592. doi:https://doi.org/10.1167/iovs.08-2744
Distribution and Heritability of Iris Thickness and Pupil Size in Chinese: The Guangzhou Twin Eye Study Free
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Mingguang He; Dandan Wang; James W. Console; Jian Zhang; Yingfeng Zheng; Wenyong Huang
Tags: chinese (other dialects), eye, immune reconstitution inflammatory syndrome, iris, pupil size
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1593-1597. doi:https://doi.org/10.1167/iovs.08-2735
Incidence of Myopia in High School Students with and without Red-Green Color Vision Deficiency Free
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Yi-Shan Qian; Ren-Yuan Chu; Ji C. He; Xing-Huai Sun; Xing-Tao Zhou; Nai-Qing Zhao; Dan-Ning Hu; Matthew R. Hoffman; Jin-Hui Dai; Xiao-Mei Qu; Kristina E. Yi-Hwa Pao
Tags: cardiovascular diseases, color vision, color vision defect, myopia, refractive errors
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1598-1605. doi:https://doi.org/10.1167/iovs.07-1362

Cornea

Collagen Cross-Links Reduce Corneal Permeability Free
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Jay M. Stewart; David S. Schultz; On-Tat Lee; Monique L. Trinidad
Tags: collagen, cornea, permeability, diffusion
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1606-1612. doi:https://doi.org/10.1167/iovs.08-2727
Regulation of Blood Vessel versus Lymphatic Vessel Growth in the Cornea Free
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Eui-Sang Chung; Daniel R. Saban; Sunil K. Chauhan; Reza Dana
Tags: cornea, fibroblast growth factor 2, lymphatic vessels, phenotype, implantation procedure
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1613-1618. doi:https://doi.org/10.1167/iovs.08-2212
Stimulatory Role of PKCα in Extracellular Regulated Kinase 1/2 Pathway in Conjunctival Goblet Cell Proliferation Free
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Marie A. Shatos; Robin R. Hodges; Jeffrey A. Bair; Kameran Lashkari; Darlene A. Dartt
Tags: conjunctiva, goblet cells, phosphotransferases
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1619-1625. doi:https://doi.org/10.1167/iovs.08-2930
Regulatory Function of CpG-Activated B Cells in Late-Phase Experimental Allergic Conjunctivitis Free
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Dai Miyazaki; Chuan Hui Kuo; Takeshi Tominaga; Yoshitsugu Inoue; Santa Jeremy Ono
Tags: allergic conjunctivitis, b-lymphocytes, interleukin-10, mice, oligonucleotides
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1626-1635. doi:https://doi.org/10.1167/iovs.08-2701
Bovine Lactoferrin Stimulates Human Corneal Epithelial Alkali Wound Healing In Vitro Free
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Ushasree Pattamatta; Mark Willcox; Fiona Stapleton; Nerida Cole; Qian Garrett
Tags: alkalies, cornea, interleukin-6, lactoferrin, platelet-derived growth factor
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1636-1643. doi:https://doi.org/10.1167/iovs.08-1882
Multiple Endpoint Analysis of the 3D-Reconstituted Corneal Epithelium after Treatment with Benzalkonium Chloride: Early Detection of Toxic Damage Free
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Aude Pauly; Marisa Meloni; Françoise Brignole-Baudouin; Jean-Michel Warnet; Christophe Baudouin
Tags: aftercare, benzalkonium chloride, corneal epithelium, early diagnosis, frozen sections
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1644-1652. doi:https://doi.org/10.1167/iovs.08-2992
Actin and Type I Collagen Propeptide Distribution in the Developing Chick Cornea Free
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Claire Gealy; Anthony J. Hayes; Rebecca Buckwell; Robert D. Young; Bruce Caterson; Andrew J. Quantock; James R. Ralphs
Tags: actins, collagen type i, cornea, procollagen, microfilaments
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1653-1658. doi:https://doi.org/10.1167/iovs.08-2554
Subconjunctival Injection of Bevacizumab (Avastin) on Corneal Neovascularization in Different Rabbit Models of Corneal Angiogenesis Free
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Wei-Li Chen; Chung-Tien Lin; Nien-Ting Lin; I-Hua Tu; Jing-Wen Li; Lu-Ping Chow; Kwan-Rong Liu; Fung-Rong Hu
Tags: bevacizumab, cornea, oryctolagus cuniculus, corneal neovascularization, alkalies
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1659-1665. doi:https://doi.org/10.1167/iovs.08-1997

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Association of Optic Disc Size with Development and Prognosis of Leber’s Hereditary Optic Neuropathy Free
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Carolina do V. F. Ramos; Costantino Bellusci; Giacomo Savini; Michele Carbonelli; Adriana Berezovsky; Celina Tamaki; Rafael Cinoto; Paula Y. Sacai; Milton N. Moraes-Filho; Hevillin M. P. P. Miura; Maria Lucia Valentino; Luisa Iommarini; Anna Maria De Negri; Federico Sadun; Pietro Cortelli; Pasquale Montagna; Solange R. Salomao; Alfredo A. Sadun; Valerio Carelli; Piero Barboni
Tags: optic atrophy, hereditary, leber, optic disk
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1666-1674. doi:https://doi.org/10.1167/iovs.08-2695

Glaucoma

Detection of Progressive Retinal Nerve Fiber Layer Loss in Glaucoma Using Scanning Laser Polarimetry with Variable Corneal Compensation Free
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Felipe A. Medeiros; Luciana M. Alencar; Linda M. Zangwill; Christopher Bowd; Gianmarco Vizzeri; Pamela A. Sample; Robert N. Weinreb
Tags: cornea, eye, glaucoma, retinal nerve fiber layer, scanning laser polarimetry
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1675-1681. doi:https://doi.org/10.1167/iovs.08-2712
Optic Disc Progression in Glaucoma: Comparison of Confocal Scanning Laser Tomography to Optic Disc Photographs in a Prospective Study Free
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Balwantray C. Chauhan; Donna M. Hutchison; Paul H. Artes; Joseph Caprioli; Jost B. Jonas; Raymond P. LeBlanc; Marcelo T. Nicolela
Tags: antidepressive agents, tricyclic, glaucoma, lasers, optic disk, prospective studies
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1682-1691. doi:https://doi.org/10.1167/iovs.08-2457
Preferential Fluid Flow in the Human Trabecular Meshwork Near Collector Channels Free
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Cheryl R. Hann; Michael P. Fautsch
Tags: eye, fluid flow, trabecular meshwork, perfusion
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1692-1697. doi:https://doi.org/10.1167/iovs.08-2375
SB-431542 Inhibition of Scar Formation after Filtration Surgery and Its Potential Mechanism Free
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Yi-qin Xiao; Kun Liu; Jian-feng Shen; Guo-Tong Xu; Wen Ye
Tags: actins, cicatrix, connective tissue growth factor, filtering surgery, surgical procedures, operative
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1698-1706. doi:https://doi.org/10.1167/iovs.08-1675
Reactivation of Optic Nerve Head Astrocytes by TGF-β2 and H2O2 Is Accompanied by Increased Hsp32 and Hsp47 Expression Free
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Alice L. Yu; Jerome Moriniere; Marco Birke; Carolin Neumann; Rudolf Fuchshofer; Anselm Kampik; Hans Bloemendal; Ulrich Welge-Lussen
Tags: astrocytes, heme oxygenase (decyclizing), immunohistochemistry, optic disk, polymerase chain reaction
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1707-1717. doi:https://doi.org/10.1167/iovs.08-1961
Evaluating Clinical Change and Visual Function Concerns in Drivers and Nondrivers with Glaucoma Free
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Nancy K. Janz; David C. Musch; Brenda W. Gillespie; Patricia A. Wren; Leslie M. Niziol
Tags: follow-up, glaucoma, vision, eye
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1718-1725. doi:https://doi.org/10.1167/iovs.08-2575
Comparing the Full-Threshold and Swedish Interactive Thresholding Algorithms for Short-Wavelength Automated Perimetry Free
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Minna Ng; Lyne Racette; John P. Pascual; Jeffrey M. Liebmann; Christopher A. Girkin; Sarah L. Lovell; Linda M. Zangwill; Robert N. Weinreb; Pamela A. Sample
Tags: depression, post-stroke, perimetry, persistent speech disorders, shedler-westen assessment procedure–200, swedish
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1726-1733. doi:https://doi.org/10.1167/iovs.08-2718

Immunology and Microbiology

Human Leukocyte Antigen (HLA)-B, DRB1, and DQB1 Allotypes Associated with Disease and Protection of Trachoma Endemic Villagers Free
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Muneer Abbas; Linda D. Bobo; Yu-Hsiang Hsieh; Noureddine Berka; Georgia Dunston; George E. Bonney; Victor Apprey; Thomas C. Quinn; Sheila K. West
Tags: human leukocyte antigens, trachoma, dna, eyelid trichiasis
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1734-1738. doi:https://doi.org/10.1167/iovs.08-2053
Nucleotide Oligomerization Domain-2 (NOD2)-Induced Uveitis: Dependence on IFN-γ Free
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Holly L. Rosenzweig; Tatsushi Kawaguchi; Tammy M. Martin; Stephen R. Planck; Michael P. Davey; James T. Rosenbaum
Tags: eye, eye inflammation, mice, nucleotides, uveitis
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1739-1745. doi:https://doi.org/10.1167/iovs.08-2756
NOD1 Expression in the Eye and Functional Contribution to IL-1β–Dependent Ocular Inflammation in Mice Free
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Holly L. Rosenzweig; Kellen T. Galster; Stephen R. Planck; James T. Rosenbaum
Tags: bacterial endocarditis, eye, eye inflammation, ireland, mice
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1746-1753. doi:https://doi.org/10.1167/iovs.08-2852
In Vitro Effect of TNF-α and IFN-γ in Retinal Cell Infection with Toxoplasma gondii Free
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Emmanuelle Delair; Claudine Creuzet; Jean Dupouy-Camet; Marie-Paule Roisin
Tags: cytokine, infections, tumor necrosis factors, toxoplasma gondii
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1754-1760. doi:https://doi.org/10.1167/iovs.07-1376
Local Ocular Immunomodulation Resulting from Electrotransfer of Plasmid Encoding Soluble TNF Receptors in the Ciliary Muscle Free
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Laura Kowalczuk; Elodie Touchard; Serge Camelo; Marie-Christine Naud; Beatriz Castaneda; Nadege Brunel; Bernadette Besson-Lescure; Brigitte Thillaye-Goldenberg; Pascal Bigey; David BenEzra; Yvonne de Kozak; Francine Behar-Cohen
Tags: chemokines, ciliary muscle, cytokine, eye, immunomodulation
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1761-1768. doi:https://doi.org/10.1167/iovs.08-3027

Lens

Abundant Expression of Ponsin, a Focal Adhesion Protein, in Lens and Downregulation of Its Expression by Impaired Cytoskeletal Signaling Free
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P. Vasantha Rao; Rupalatha Maddala
Tags: cytoskeleton, down-regulation, focal adhesions, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1769-1777. doi:https://doi.org/10.1167/iovs.08-2909

Physiology and Pharmacology

Poly(ADP-Ribose)Polymerase Inhibition Counteracts Cataract Formation and Early Retinal Changes in Streptozotocin-Diabetic Rats Free
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Viktor R. Drel; Weizheng Xu; Jie Zhang; Peter F. Kador; Tayyeba K. Ali; Jeho Shin; Ulrich Julius; Barbara Slusher; Azza B. El-Remessy; Irina G. Obrosova
Tags: adenosine diphosphate ribose, cataract, diabetes mellitus, rats, streptozocin
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1778-1790. doi:https://doi.org/10.1167/iovs.08-2191
Studies on Bicarbonate Transporters and Carbonic Anhydrase in Porcine Nonpigmented Ciliary Epithelium Free
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Mohammad Shahidullah; Chi-Ho To; Ryan M. Pelis; Nicholas A. Delamere
Tags: 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid, acetazolamide, bicarbonates, carbon dioxide, carbonate dehydratase
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1791-1800. doi:https://doi.org/10.1167/iovs.08-2487
Functional CNTF Receptor α Subunit Restored by Its Recombinant in Corneal Endothelial Cells in Stored Human Donor Corneas: Connexin-43 Upregulation Free
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Shay-Whey M. Koh; Jordan Celeste; C. Y. Paul Ku
Tags: ciliary neurotrophic factor, ciliary neurotrophic factor receptors, connexin 43, cornea, donors
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1801-1807. doi:https://doi.org/10.1167/iovs.08-2590
Characterization of Soluble Guanylate Cyclase in NO-Induced Increases in Aqueous Humor Outflow Facility and in the Trabecular Meshwork Free
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Dorette Z. Ellis; William M. Dismuke; Binna M. Chokshi
Tags: soluble guanylyl cyclase, aqueous humor, trabecular meshwork
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1808-1813. doi:https://doi.org/10.1167/iovs.08-2750

Retina

Coenzyme Q10 in the Human Retina Free
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Jinfeng Qu; Yardana Kaufman; Ilyas Washington
Tags: coenzyme q10, retina
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1814-1818. doi:https://doi.org/10.1167/iovs.08-2656
Antitumor Activity of Arsenic Trioxide on Retinoblastoma: Cell Differentiation and Apoptosis Depending on Arsenic Trioxide Concentration Free
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Jeong Hun Kim; Jin Hyoung Kim; Young Suk Yu; Dong Hun Kim; Chong Jai Kim; Kyu-Won Kim
Tags: retinoblastoma, arsenic trioxide, apoptosis, mass or substance concentration per volume, neoplasms
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1819-1823. doi:https://doi.org/10.1167/iovs.08-2623
Blood Flow Magnetic Resonance Imaging of Retinal Degeneration Free
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Yingxia Li; Haiying Cheng; Qiang Shen; Moon Kim; Peter M. Thule; Darin E. Olson; Machelle T. Pardue; Timothy Q. Duong
Tags: hypercapnia, hyperoxia, magnetic resonance imaging, retina, retinal degeneration
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1824-1830. doi:https://doi.org/10.1167/iovs.08-2188
Quantification and Localization of the IGF/Insulin System Expression in Retinal Blood Vessels and Neurons during Oxygen-Induced Retinopathy in Mice Free
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Chatarina Lofqvist; Keirnan L. Willett; Oskar Aspegren; Alexandra C. H. Smith; Christopher M. Aderman; Kip M. Connor; Jing Chen; Ann Hellstrom; Lois E. H. Smith
Tags: insulin, mice, oxygen, retina, retinal diseases
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1831-1837. doi:https://doi.org/10.1167/iovs.08-2903
Adaptive Optics Scanning Laser Ophthalmoscopy Images in a Family with the Mitochondrial DNA T8993C Mutation Free
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Michael K. Yoon; Austin Roorda; Yuhua Zhang; Chiaki Nakanishi; Lee-Jun C. Wong; Qing Zhang; Leslie Gillum; Ari Green; Jacque L. Duncan
Tags: dna, mitochondrial, family, mutation, optics, retinal cone
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1838-1847. doi:https://doi.org/10.1167/iovs.08-2029
A Comparison of Macular Translocation with Patch Graft in Neovascular Age-Related Macular Degeneration Free
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Fred K. Chen; Praveen J. Patel; Gurmit S. Uppal; Gary S. Rubin; Peter J. Coffey; G. William Aylward; Lyndon Da Cruz
Tags: choroidal neovascularization, exudative age-related macular degeneration, surgical procedures, operative, tissue transplants, translocation (genetics)
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1848-1855. doi:https://doi.org/10.1167/iovs.08-2845
Wide-Field Optical Coherence Tomography of the Choroid In Vivo Free
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Boris Považay; Boris Hermann; Bernd Hofer; Vedran Kajić; Elizabeth Simpson; Thomas Bridgford; Wolfgang Drexler
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1856-1863. doi:https://doi.org/10.1167/iovs.08-2869
A Homozygous Missense Mutation in the IRBP Gene (RBP3) Associated with Autosomal Recessive Retinitis Pigmentosa Free
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Anneke I. den Hollander; Terri L. McGee; Carmela Ziviello; Sandro Banfi; Thaddeus P. Dryja; Federico Gonzalez-Fernandez; Debashis Ghosh; Eliot L. Berson
Tags: autosomal recessive inheritance, e2f1 gene, family, genes, homozygote
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1864-1872. doi:https://doi.org/10.1167/iovs.08-2497
Role of PI3K/Akt and MEK/ERK in Mediating Hypoxia-Induced Expression of HIF-1α and VEGF in Laser-Induced Rat Choroidal Neovascularization Free
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Xiu-Mei Yang; Yu-Sheng Wang; Jian Zhang; Yan Li; Jian-Feng Xu; Jie Zhu; Wei Zhao; Da-Ke Chu; Peter Wiedemann
Tags: 1-phosphatidylinositol 3-kinase, choroidal neovascularization, hypoxia, lasers, phosphoinositide 3-kinase
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1873-1879. doi:https://doi.org/10.1167/iovs.08-2591
Quantitative Mapping of Ion Channel Regulation by Visual Cycle Activity in Rodent Photoreceptors In Vivo Free
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Bruce A. Berkowitz; Robin Roberts; Deanna A. Oleske; Myungwon Chang; Stephen Schafer; David Bissig; Marius Gradianu
Tags: ion channels, manganese, mice, photoreceptors, regulation
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1880-1885. doi:https://doi.org/10.1167/iovs.08-2958
Disease Boundaries in the Retina of Patients with Usher Syndrome Caused by MYO7A Gene Mutations Free
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Samuel G. Jacobson; Tomas S. Aleman; Alexander Sumaroka; Artur V. Cideciyan; Alejandro J. Roman; Elizabeth A. M. Windsor; Sharon B. Schwartz; Heidi L. Rehm; William J. Kimberling
Tags: mutation, retina, usher syndrome
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1886-1894. doi:https://doi.org/10.1167/iovs.08-3122
Dysfunction of the Retinal Pigment Epithelium with Age: Increased Iron Decreases Phagocytosis and Lysosomal Activity Free
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Huiyi Chen; Thomas J. Lukas; Nga Du; Genn Suyeoka; Arthur H. Neufeld
Tags: iron, choroid, phagocytosis, retinal pigment cell
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1895-1902. doi:https://doi.org/10.1167/iovs.08-2850

Retinal Cell Biology

CTGF Is Increased in Basal Deposits and Regulates Matrix Production through the ERK (p42/p44mapk) MAPK and the p38 MAPK Signaling Pathways Free
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Norihiro Nagai; Alena Klimava; Wen-Hsiang Lee; Kanako Izumi-Nagai; James T. Handa
Tags: connective tissue growth factor, mitogen-activated protein kinase p38, mitogen-activated protein kinases, signal pathway, signal transduction pathways
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1903-1910. doi:https://doi.org/10.1167/iovs.08-2383
Synthesis and Secretion of Hemoglobin by Retinal Pigment Epithelium Free
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Tongalp H. Tezel; Lijun Geng; Ewa Bodek Lato; Shlomit Schaal; Yongqing Liu; Douglas Dean; Jon B. Klein; Henry J. Kaplan
Tags: hemoglobin, retinal pigment epithelium, proteins, bodily secretions, globins
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1911-1919. doi:https://doi.org/10.1167/iovs.07-1372
Differential Regulation of High Glucose–Induced Glyceraldehyde-3-Phosphate Dehydrogenase Nuclear Accumulation in Müller Cells by IL-1β and IL-6 Free
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E. Chepchumba K. Yego; Jason A. Vincent; Vijay Sarthy; Julia V. Busik; Susanne Mohr
Tags: glucose, interleukin-6, cytokine, glyceraldehyde-3-phosphate dehydrogenases
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1920-1928. doi:https://doi.org/10.1167/iovs.08-2082
Fibrocontractive Müller Cell Phenotypes in Proliferative Diabetic Retinopathy Free
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Clyde Guidry; Jeffery L. King; John O. Mason, III
Tags: antibodies, glial fibrillary acidic protein, glutamate-ammonia ligase, phenotype, proliferative diabetic retinopathy
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1929-1939. doi:https://doi.org/10.1167/iovs.08-2475
Sublethal Photic Stress and the Motility of RPE Phagosomes and Melanosomes Free
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Janice M. Burke; Mariusz Zareba
Tags: cell motility, melanosomes, organelles, phagosomes, stress
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1940-1947. doi:https://doi.org/10.1167/iovs.08-2671

Visual Neuroscience

Selective Hcn1 Channels Inhibition by Ivabradine in Mouse Rod Photoreceptors Free
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Gian Carlo Demontis; Claudia Gargini; Timoteo Giacomo Paoli; Luigi Cervetto
Tags: ivabradine, mice, rod photoreceptors, voltage
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1948-1955. doi:https://doi.org/10.1167/iovs.08-2659

Visual Psychophysics and Physiological Optics

Low-Spatial-Frequency Channels and the Spatial Frequency-Doubling Illusion Free
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Yanti Rosli; Suzanne M. Bedford; Ted Maddess
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Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1956-1963. doi:https://doi.org/10.1167/iovs.08-1810
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Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1964-1970. doi:https://doi.org/10.1167/iovs.08-2111

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Tags: electric stimulation, visual prosthesis, prostheses, psychophysics
Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1483-1491. doi:https://doi.org/10.1167/iovs.08-2595
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Tags: child, phase 1 clinical trials, retinoblastoma, intraocular, pediatric, topotecan, toxic effect
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Research Opportunities

The Glaucoma Research Community and FDA Look to the Future: A Report from the NEI/FDA CDER Glaucoma Clinical Trial Design and Endpoints Symposium* Free
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Tags: glaucoma, surrogate endpoints, united states food and drug administration
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Erratum

ERRATUM Free
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Investigative Ophthalmology & Visual Science April 2009, Vol.50, 1530. doi:
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