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Anatomy and Pathology/Oncology

MET Oncogene Inhibition as a Potential Target of Therapy for Uveal Melanomas Free
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Mohamed H. Abdel-Rahman; Getachew Boru; James Massengill; Manar M. Salem; Frederick H. Davidorf
Tags: cell lines, immunohistochemistry, neoplasms, oncogenes, proteins
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3333-3339. doi:https://doi.org/10.1167/iovs.09-4801

Biochemistry and Molecular Biology

Mitochondrial DNA Defects and Selective Extraocular Muscle Involvement in CPEO Free
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Laura C. Greaves; Patrick Yu-Wai-Man; Emma L. Blakely; Kim J. Krishnan; Nina E. Beadle; Jamie Kerin; Martin J. Barron; Philip G. Griffiths; Alison J. Dickinson; Douglass M. Turnbull; Robert W. Taylor
Tags: dna, mitochondrial, ophthalmoplegia, external, progressive, chronic, muscle of orbit, skeletal muscles
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3340-3346. doi:https://doi.org/10.1167/iovs.09-4659
Somatic Mitochondrial DNA Deletions Accumulate to High Levels in Aging Human Extraocular Muscles Free
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Patrick Yu-Wai-Man; Joey Lai-Cheong; Gillian M. Borthwick; Langping He; Geoffrey A. Taylor; Laura C. Greaves; Robert W. Taylor; Philip G. Griffiths; Douglass M. Turnbull
Tags: aging, dna, mitochondrial, muscle of orbit, mitochondria
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3347-3353. doi:https://doi.org/10.1167/iovs.09-4660
Alterations of the 5′Untranslated Region of SLC16A12 Lead to Age-Related Cataract Free
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Jurian Zuercher; John Neidhardt; Istvan Magyar; Stephan Labs; Anthony T. Moore; Felix C. Tanner; Naushin Waseem; Daniel F. Schorderet; Francis L. Munier; Shomi Bhattacharya; Wolfgang Berger; Barbara Kloeckener-Gruissem
Tags: alleles, cataract, cataract, senile, mutation, rna
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3354-3361. doi:https://doi.org/10.1167/iovs.10-5193
SDF-1/CXCR4 Contributes to the Activation of Tip Cells and Microglia in Retinal Angiogenesis Free
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Noriyuki Unoki; Tomoaki Murakami; Kazuaki Nishijima; Ken Ogino; Nico van Rooijen; Nagahisa Yoshimura
Tags: angiogenesis, cxcr4 receptors, microglia, stromal cell-derived factor 1, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3362-3371. doi:https://doi.org/10.1167/iovs.09-4978
Taz-Tead1 Links Cell-Cell Contact to Zeb1 Expression, Proliferation, and Dedifferentiation in Retinal Pigment Epithelial Cells Free
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Yongqing Liu; Ying Xin; Fei Ye; Wei Wang; Qingxian Lu; Henry J. Kaplan; Douglas C. Dean
Tags: anaplasia, retinal pigment cell, epithelial to mesenchymal transition
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3372-3378. doi:https://doi.org/10.1167/iovs.09-4321
Identification of Novel Substrates for the Serine Protease HTRA1 in the Human RPE Secretome Free
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Eunkyung An; Supti Sen; Sung Kyu Park; Heather Gordish-Dressman; Yetrib Hathout
Tags: htra1 gene, proteins, retinal pigment cell, serine endopeptidases
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3379-3386. doi:https://doi.org/10.1167/iovs.09-4853

Clinical and Epidemiologic Research

Patient Preferences for Diabetic Retinopathy Health States Free
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Shelagh M. Szabo; Kathleen M. Beusterien; Andreas M. Pleil; Barbara Wirostko; Michael J. Potter; Hugh Tildesley; John Gonder; Alexandra Barsdorf; Adrian R. Levy
Tags: contrast sensitivity, diabetic retinopathy, eye, health, visual acuity
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3387-3394. doi:https://doi.org/10.1167/iovs.09-4194
Treating Amblyopia with Liquid Crystal Glasses: A Pilot Study Free
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Abraham Spierer; Judith Raz; Omry BenEzra; Rafi Herzog; Evelyne Cohen; Ilana Karshai; David BenEzra
Tags: amblyopia, eyeglasses, liquid crystals, pilot projects, eye
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3395-3398. doi:https://doi.org/10.1167/iovs.09-4568
Distribution of Ocular Perfusion Pressure and Its Relationship with Open-Angle Glaucoma: The Singapore Malay Eye Study Free
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Yingfeng Zheng; Tien Y. Wong; Paul Mitchell; David S. Friedman; Mingguang He; Tin Aung
Tags: eye, glaucoma, intraocular pressure, open-angle glaucoma, perfusion
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3399-3404. doi:https://doi.org/10.1167/iovs.09-4867
Vision-Related Quality of Life after Transsphenoidal Surgery for Pituitary Adenoma Free
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Yoshifumi Okamoto; Fumiki Okamoto; Shozo Yamada; Maiko Honda; Takahiro Hiraoka; Tetsuro Oshika
Tags: pituitary adenoma, quality of life, surgical procedures, operative, vision
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3405-3410. doi:https://doi.org/10.1167/iovs.09-3763
Prevalence of Amblyopia and Strabismus in Young Singaporean Chinese Children Free
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Audrey Chia; Mohamed Dirani; Yiong-Huak Chan; Gus Gazzard; Kah-Guan Au Eong; Prabakaran Selvaraj; Yvonne Ling; Boon-Long Quah; Terri L. Young; Paul Mitchell; Rohit Varma; Tien-Yin Wong; Seang-Mei Saw
Tags: amblyopia, child, chinese (other dialects), prevalence, strabismus
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3411-3417. doi:https://doi.org/10.1167/iovs.09-4461

Cornea

Regulation of T-Cell Chemotaxis by Programmed Death-Ligand 1 (PD-L1) in Dry Eye–Associated Corneal Inflammation Free
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Jaafar El Annan; Sunali Goyal; Qiang Zhang; Gordon J. Freeman; Arlene H. Sharpe; Reza Dana
Tags: chemokines, chemotaxis, cornea, dry eye syndromes, keratitis
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3418-3423. doi:https://doi.org/10.1167/iovs.09-3684
Detection of Subclinical Keratoconus by Using Corneal Anterior and Posterior Surface Aberrations and Thickness Spatial Profiles Free
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Jens Bühren; Daniel Kook; Geunyoung Yoon; Thomas Kohnen
Tags: cornea, eye, keratoconus, optical pachymetry, roc curve
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3424-3432. doi:https://doi.org/10.1167/iovs.09-4960
Biometry of the Cornea and Anterior Chamber in Chinese Eyes: An Anterior Segment Optical Coherence Tomography Study Free
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Leonard H. Yuen; Mingguang He; Tin Aung; Hla M. Htoon; Donald T. Tan; Jodhbir S. Mehta
Tags: anterior chamber of eye, biometry, chinese (other dialects), chinese people, cornea
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3433-3440. doi:https://doi.org/10.1167/iovs.09-4307
Simultaneous Measurement of Tear Film Dynamics Using Wavefront Sensor and Optical Coherence Tomography Free
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Shizuka Koh; Cynthia Tung; James Aquavella; Rahul Yadav; James Zavislan; Geunyoung Yoon
Tags: dry eye syndromes, optical coherence tomography, sensor, tear film finding, optics
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3441-3448. doi:https://doi.org/10.1167/iovs.09-4430
Screening for Meibomian Gland Disease: Its Relation to Dry Eye Subtypes and Symptoms in a Tertiary Referral Clinic in Singapore Free
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Louis Tong; Shyam S. Chaurasia; Jodhbir S. Mehta; Roger W. Beuerman
Tags: dry eye syndromes, signs and symptoms, screening, meibomian gland
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3449-3454. doi:https://doi.org/10.1167/iovs.09-4445
Transforming Growth Factor-α Enhances Corneal Epithelial Cell Migration by Promoting EGFR Recycling Free
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Jennifer L. McClintock; Brian P. Ceresa
Tags: epidermal growth factor receptors, corneal epithelial cells, ligands
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3455-3461. doi:https://doi.org/10.1167/iovs.09-4386
Effect of TIMP-1 and MMP in Pterygium Invasion Free
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Yi-Yu Tsai; Chun-Chi Chiang; Kun-Tu Yeh; Huei Lee; Ya-Wen Cheng
Tags: proteins, pterygium, tissue inhibitor of metalloproteinases, tissue-inhibitor of metalloproteinase-1, gelatinase b
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3462-3467. doi:https://doi.org/10.1167/iovs.09-4921
The Shape of Posterior Corneal Surface in Normal, Post-LASIK, and Post–epi-LASIK Eyes Free
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Lin Zhang; Yan Wang
Tags: cornea, eye, keratomileusis, laser in situ, surgical procedures, operative, optics
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3468-3475. doi:https://doi.org/10.1167/iovs.09-4811

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Rotterdam AMblyopia Screening Effectiveness Study: Detection and Causes of Amblyopia in a Large Birth Cohort Free
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Johanna H. Groenewoud; Angela M. Tjiam; V. Kathleen Lantau; W. Christina Hoogeveen; Jan Tjeerd H. N. de Faber; Rikard E. Juttmann; Harry J. de Koning; Huibert J. Simonsz
Tags: amblyopia, child, cohort studies, screening, vision screening
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3476-3484. doi:https://doi.org/10.1167/iovs.08-3352
Effects of Intracranial Trochlear Neurectomy on the Structure of the Primate Superior Oblique Muscle Free
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Joseph L. Demer; Vadims Poukens; Howard Ying; Xiaoyan Shan; Jing Tian; David S. Zee
Tags: cercopithecidae, denervation, magnetic resonance imaging, muscle, orbit
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3485-3493. doi:https://doi.org/10.1167/iovs.09-5120
Human Extraocular Muscles in ALS Free
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Mahboobah Ahmadi; Jing-Xia Liu; Thomas Brännström; Peter M. Andersen; Per Stål; Fatima Pedrosa-Domellöf
Tags: limb, muscle, muscle fibers, muscle of orbit, donors
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3494-3501. doi:https://doi.org/10.1167/iovs.09-5030
Reading Strategies in Mild to Moderate Strabismic Amblyopia: An Eye Movement Investigation Free
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Evgenia Kanonidou; Frank A. Proudlock; Irene Gottlob
Tags: amblyopia, eye movement, reading (activity), strabismic amblyopia, eye
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3502-3508. doi:https://doi.org/10.1167/iovs.09-4236

Glaucoma

The Path to Open-Angle Glaucoma Gene Discovery: Endophenotypic Status of Intraocular Pressure, Cup-to-Disc Ratio, and Central Corneal Thickness Free
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Jac Charlesworth; Patricia L. Kramer; Tom Dyer; Victor Diego; John R. Samples; Jamie E. Craig; David A. Mackey; Alex W. Hewitt; John Blangero; Mary K. Wirtz
Tags: cornea, genes, intraocular pressure, open-angle glaucoma, genetics
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3509-3514. doi:https://doi.org/10.1167/iovs.09-4786
Analysis of Peripapillary Retinal Nerve Fiber Distribution in Normal Young Adults Free
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Seung Woo Hong; Myung Douk Ahn; Shin Hee Kang; Seong Kyu Im
Tags: eye, nerve fibers, optic disk, retinal nerve fiber layer, young adult
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3515-3523. doi:https://doi.org/10.1167/iovs.09-4888
Hypotensive Medication, Statins, and the Risk of Glaucoma Free
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Christopher G. Owen; Iain M. Carey; Sunil Shah; Stephen de Wilde; Richard Wormald; Peter H. Whincup; Derek G. Cook
Tags: glaucoma, pharmaceutical preparations, statins
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3524-3530. doi:https://doi.org/10.1167/iovs.09-4821
A Comparison of Rates of Change in Neuroretinal Rim Area and Retinal Nerve Fiber Layer Thickness in Progressive Glaucoma Free
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Luciana M. Alencar; Linda M. Zangwill; Robert N. Weinreb; Christopher Bowd; Pamela A. Sample; Christopher A. Girkin; Jeffrey M. Liebmann; Felipe A. Medeiros
Tags: eye, glaucoma, neuroretinal rim, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3531-3539. doi:https://doi.org/10.1167/iovs.09-4350
Monitoring Vigilance during Perimetry by Using Pupillography Free
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David B. Henson; Thomas Emuh
Tags: fatigue, perimetry, pupil, diameter, wave - physical agent
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3540-3543. doi:https://doi.org/10.1167/iovs.09-4413
Neuroprotective Effects of C-Type Natriuretic Peptide on Rat Retinal Ganglion Cells Free
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Jia Ma; Wenhan Yu; Yun Wang; Guiqun Cao; Suping Cai; Xiaoming Chen; Naihong Yan; Yuansheng Yuan; Hong Zeng; Debra L. Fleenor; Xuyang Liu; Iok-Hou Pang
Tags: intravitreal injections, natriuretic peptide, c-type, neuroprotective effect, n-methylaspartate, retina
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3544-3553. doi:https://doi.org/10.1167/iovs.09-5049

Immunology and Microbiology

μ-Crystallin, New Candidate Protein in Endotoxin-Induced Uveitis Free
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Hiroki Imai; Kouichi Ohta; Akiko Yoshida; Satoru Suzuki; Kiyoshi Hashizume; Shinichi Usami; Takanobu Kikuchi
Tags: crystallins, endotoxins, mice, proteins, uveitis
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3554-3559. doi:https://doi.org/10.1167/iovs.09-3728
Targeting Immune Privilege to Prevent Pathogenic Neovascularization Free
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Jayeeta Roychoudhury; John M. Herndon; Jiyi Yin; Rajendra S. Apte; Thomas A. Ferguson
Tags: choroidal neovascularization, doxycycline, lasers, mice, neovascularization, pathologic
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3560-3566. doi:https://doi.org/10.1167/iovs.09-3890
p38α MAP Kinase Controls IL-17 Synthesis in Vogt-Koyanagi-Harada Syndrome and Experimental Autoimmune Uveitis Free
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Alessandra Gonçalves Commodaro; Cíntia Raquel Bombardieri; Jean Pierre Schatzmann Peron; Kelly Cristina Saito; Pedro Mancini Guedes; Dânia E. Hamassaki; Rubens N. Belfort; Luiz Vicente Rizzo; Rubens Belfort, Jr; Maristela Martins de Camargo
Tags: autoimmune diseases, interleukin-17, mice, mitogen-activated protein kinases, uveitis
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3567-3574. doi:https://doi.org/10.1167/iovs.09-4393
Treatment of Experimental Autoimmune Uveoretinitis with Intravitreal Injection of Tacrolimus (FK506) Encapsulated in Liposomes Free
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Rui Zhang; Rong He; Jiang Qian; Jie Guo; Kang Xue; Yi-fei Yuan
Tags: intravitreal injections, liposomes, tacrolimus, lip, autoimmune diseases
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3575-3582. doi:https://doi.org/10.1167/iovs.09-4373
Conjunctival Expression of Matrix Metalloproteinase and Proinflammatory Cytokine Genes after Trichiasis Surgery Free
PDF
Matthew J. Burton; Robin L. Bailey; David Jeffries; Saul N. Rajak; Richard A. Adegbola; Ansumana Sillah; David C. W. Mabey; Martin J. Holland
Tags: conjunctiva, eyelid trichiasis, gene expression, matrix metalloproteinases, surgical procedures, operative
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3583-3590. doi:https://doi.org/10.1167/iovs.09-4550
A Novel p40-Independent Function of IL-12p35 Is Required for Progression and Maintenance of Herpes Stromal Keratitis Free
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Gregory M. Frank; Sherrie J. Divito; Dawn M. Maker; Min Xu; Robert L. Hendricks
Tags: chemokines, cornea, cytokine, interleukin-12 subunit p40, mice
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3591-3598. doi:https://doi.org/10.1167/iovs.09-4368

Lens

Growth Factor Signaling in Vitreous Humor–Induced Lens Fiber Differentiation Free
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Qian Wang; John W. McAvoy; Frank J. Lovicu
Tags: growth factor, lens (device), lens, crystalline, signal transduction, vitreous body
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3599-3610. doi:https://doi.org/10.1167/iovs.09-4797
The Tumor Suppressor Merlin Is Required for Cell Cycle Exit, Terminal Differentiation, and Cell Polarity in the Developing Murine Lens Free
PDF
Luke A. Wiley; Lisa K. Dattilo; Kai B. Kang; Marco Giovannini; David C. Beebe
Tags: lens (device), lens, crystalline, cell cycle, genes, neurofibromatosis 2, cell polarity
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3611-3618. doi:https://doi.org/10.1167/iovs.09-4371

Physiology and Pharmacology

Glutamate Stimulation of Retinal Ganglion Cells in Normal and S334ter-4 Rat Retinas: A Candidate for a Neurotransmitter-Based Retinal Prosthesis Free
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Paul G. Finlayson; Raymond Iezzi
Tags: glutamate, glutamates, retina, neurotransmitters, visual prosthesis
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3619-3628. doi:https://doi.org/10.1167/iovs.09-4877
Neuroprotection against Retinal Ischemia–Reperfusion Injury by Blocking the Angiotensin II Type 1 Receptor Free
PDF
Kouki Fukuda; Kazuyuki Hirooka; Masanori Mizote; Takehiro Nakamura; Toshifumi Itano; Fumio Shiraga
Tags: ischemia, retina, captopril, candesartan cilexetil, reperfusion injury
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3629-3638. doi:https://doi.org/10.1167/iovs.09-4107
Inhibition of Histone Deacetylase Protects the Retina from Ischemic Injury Free
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Craig E. Crosson; Santhosh K. Mani; Shahid Husain; Oday Alsarraf; Donald R. Menick
Tags: histone deacetylase, ischemia, retina, wounds and injuries, tumor necrosis factors
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3639-3645. doi:https://doi.org/10.1167/iovs.09-4538

Retina

A Novel Nonsense Mutation in CEP290 Induces Exon Skipping and Leads to a Relatively Mild Retinal Phenotype Free
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Karin W. Littink; Jan-Willem R. Pott; Rob W. J. Collin; Hester Y. Kroes; Joke B. G. M. Verheij; Ellen A. W. Blokland; Marta de Castro Miró; Carel B. Hoyng; Caroline C. W. Klaver; Robert K. Koenekoop; Klaus Rohrschneider; Frans P. M. Cremers; L. Ingeborgh van den Born; Anneke I. den Hollander
Tags: exons, mutation, mutation, nonsense, phenotype, visual acuity
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3646-3652. doi:https://doi.org/10.1167/iovs.09-5074
Automated Segmentation of Foveal Avascular Zone in Fundus Fluorescein Angiography Free
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Yalin Zheng; Jagdeep Singh Gandhi; Alexandros N. Stangos; Claudio Campa; Deborah M. Broadbent; Simon P. Harding
Tags: fluorescein angiography
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3653-3659. doi:https://doi.org/10.1167/iovs.09-4935
Decreased Retinal Ganglion Cell Layer Thickness in Patients with Type 1 Diabetes Free
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Hille W. van Dijk; Frank D. Verbraak; Pauline H. B. Kok; Mona K. Garvin; Milan Sonka; Kyungmoo Lee; J. Hans DeVries; Robert P. J. Michels; Mirjam E. J. van Velthoven; Reinier O. Schlingemann; Michael D. Abràmoff
Tags: diabetes mellitus, diabetes mellitus, type 1, diabetes mellitus, type 2, retinal ganglion cells, hemoglobin a, glycosylated
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3660-3665. doi:https://doi.org/10.1167/iovs.09-5041
Evaluation of CXCR4 Inhibition in the Prevention and Intervention Model of Laser-Induced Choroidal Neovascularization Free
PDF
Edwin Lee; David Rewolinski
Tags: choroidal neovascularization, cxcr4 receptors, lasers, prevention
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3666-3672. doi:https://doi.org/10.1167/iovs.09-3802
Morphologic Photoreceptor Abnormality in Occult Macular Dystrophy on Spectral-Domain Optical Coherence Tomography Free
PDF
Sang Jun Park; Se Joon Woo; Kyu Hyung Park; Jeong-Min Hwang; Hum Chung
Tags: macular dystrophy, optical coherence tomography, photoreceptors, visual acuity, eye
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3673-3679. doi:https://doi.org/10.1167/iovs.09-4169
The Role of TLR4 in Photoreceptor αA Crystallin Upregulation during Early Experimental Autoimmune Uveitis Free
PDF
Sindhu Saraswathy; Angeline M. Nguyen; Narsing A. Rao
Tags: crystallins, nitric oxide synthase, photoreceptors, retina, toll-like receptor 4
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3680-3686. doi:https://doi.org/10.1167/iovs.09-4575
Spectrum of Rhodopsin Mutations in French Autosomal Dominant Rod–Cone Dystrophy Patients Free
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Isabelle Audo; Gaël Manes; Saddek Mohand-Saïd; Anne Friedrich; Marie-Elise Lancelot; Aline Antonio; Veselina Moskova-Doumanova; Oliver Poch; Xavier Zanlonghi; Christian P. Hamel; José-Alain Sahel; Shomi S. Bhattacharya; Christina Zeitz
Tags: french, mutation, retinitis pigmentosa, rhodopsin, family
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3687-3700. doi:https://doi.org/10.1167/iovs.09-4766
Long-Term Tolerability and Serum Concentration of Bevacizumab (Avastin) when Injected in Newborn Rabbit Eyes Free
PDF
Wei-Chi Wu; Chi-Chun Lai; Kuan-Jen Chen; Tun-Lu Chen; Nan-Kai Wang; Yih-Shiou Hwang; Ling Yeung; Lien-Min Li
Tags: bevacizumab, eye, newborn, oryctolagus cuniculus, serum drug concentration
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3701-3708. doi:https://doi.org/10.1167/iovs.09-4425
Plasma sE-selectin in Premature Infants: A Possible Surrogate Marker of Retinopathy of Prematurity Free
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Christina Pieh; Marcus Krüger; Wolf Alexander Lagrèze; Charlotte Gimpel; Christiane Buschbeck; Ute Zirrgiebel; Hansjürgen T. Agostini
Tags: plasma, retinopathy of prematurity, selectins, selenium, seychelles
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3709-3713. doi:https://doi.org/10.1167/iovs.09-4723
Clinical Assessment of Mirror Artifacts in Spectral-Domain Optical Coherence Tomography Free
PDF
Joseph Ho; Dinorah P. E. Castro; Leonardo C. Castro; Yueli Chen; Jonathan Liu; Cynthia Mattox; Chandrasekharan Krishnan; James G. Fujimoto; Joel S. Schuman; Jay S. Duker
Tags: artifacts, myopia, optical coherence tomography
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3714-3720. doi:https://doi.org/10.1167/iovs.09-4057
Ocular Risk Factors for Choroidal Neovascularization in Pathologic Myopia Free
PDF
Yasushi Ikuno; Yukari Jo; Toshimitsu Hamasaki; Yasuo Tano
Tags: choroidal neovascularization, eye, myopic macular degeneration, risk factors, staphyloma
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3721-3725. doi:https://doi.org/10.1167/iovs.09-3493
Gene Expression within the Amacrine Cell Layer of Chicks after Myopic and Hyperopic Defocus Free
PDF
Regan Scott Ashby; Marita Pauline Feldkaemper
Tags: amacrine cells, gene expression, genes, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3726-3735. doi:https://doi.org/10.1167/iovs.09-4615
Relationship of Retinal Vascular Tortuosity with the Neuroretinal Rim: The Singapore Malay Eye Study Free
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Victor Koh; Carol Yim-lui Cheung; Yingfeng Zheng; Tien Yin Wong; Wanling Wong; Tin Aung
Tags: eye, neuroretinal rim, singapore, recommended daily allowance, optic disk
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3736-3741. doi:https://doi.org/10.1167/iovs.09-5008
Effects of Bone Marrow Mesenchymal Stem Cell Transplantation on Light-Damaged Retina Free
PDF
Yu Zhang; Wei Wang
Tags: bone marrow, cytokine, mesenchymal stem cells, retina, transplantation
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3742-3748. doi:https://doi.org/10.1167/iovs.08-3314
Neuronal-Driven Angiogenesis: Role of NGF in Retinal Neovascularization in an Oxygen-Induced Retinopathy Model Free
PDF
Xialin Liu; Dingding Wang; Yizhi Liu; Yan Luo; Wei Ma; Wei Xiao; Qiang Yu
Tags: angiogenesis, mice, neovascularization, pathologic, oxygen, retina
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3749-3757. doi:https://doi.org/10.1167/iovs.09-4226

Retinal Cell Biology

Reduced Connexin 43 Expression and Its Effect on the Development of Vascular Lesions in Retinas of Diabetic Mice Free
PDF
Michael W. Bobbie; Sumon Roy; Kyle Trudeau; Stephanie J. Munger; Alexander M. Simon; Sayon Roy
Tags: connexin 43, diabetes mellitus, mice, retina, vascular lesions
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3758-3763. doi:https://doi.org/10.1167/iovs.09-4489
Regulation of Retinal Progenitor Cell Differentiation by Bone Morphogenetic Protein 4 Is Mediated by the Smad/Id Cascade Free
PDF
Yang Du; Qi Xiao; Henry K. Yip
Tags: adult, bone morphogenetic proteins, mice, proteins, regulation
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3764-3773. doi:https://doi.org/10.1167/iovs.09-4906
A Comparison of Differentiation Protocols for RGC-5 Cells Free
PDF
John P. M. Wood; Glyn Chidlow; Tuyet Tran; Jonathan G. Crowston; Robert J. Casson
Tags: glutamate, glutamates, immunoblotting, mechlorethamine, proteins
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3774-3783. doi:https://doi.org/10.1167/iovs.09-4305
Preconditioning with Inhalative Carbon Monoxide Protects Rat Retinal Ganglion Cells from Ischemia/Reperfusion Injury Free
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Julia Biermann; Wolf A. Lagrèze; Cornelia Dimitriu; Christian Stoykow; Ulrich Goebel
Tags: carbon monoxide, ischemia, proteins, reperfusion injury, retinal ganglion cells
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3784-3791. doi:https://doi.org/10.1167/iovs.09-4894
The Intraflagellar Transport Protein Ift80 Is Essential for Photoreceptor Survival in a Zebrafish Model of Jeune Asphyxiating Thoracic Dystrophy Free
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Leah M. Hudak; Shannon Lunt; Chi-Hsuan Chang; Ethan Winkler; Halley Flammer; Michael Lindsey; Brian D. Perkins
Tags: carrier proteins, jeune thoracic dystrophy, photoreceptors, zebrafish, cilia
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3792-3799. doi:https://doi.org/10.1167/iovs.09-4312
Amacrine Cell Gene Expression and Survival Signaling: Differences from Neighboring Retinal Ganglion Cells Free
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Noelia J. Kunzevitzky; Monica V. Almeida; Jeffrey L. Goldberg
Tags: amacrine cells, gene expression
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3800-3812. doi:https://doi.org/10.1167/iovs.09-4540
Treating Retinoblastoma in Tissue Culture and in a Rat Model with a Novel Isoquinoline Derivative Free
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Mohamed Nassr; XiangDi Wang; Suchareeta Mitra; Natalie E. Freeman-Anderson; Renukadevi Patil; C. Ryan Yates; Duane D. Miller; Eldon E. Geisert
Tags: isoquinolines, retinoblastoma, tissue culture
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3813-3819. doi:https://doi.org/10.1167/iovs.09-5042
Suppression of Laser-Induced Choroidal Neovascularization by Nontargeted siRNA Free
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Masayuki Ashikari; Mayumi Tokoro; Masahiro Itaya; Miho Nozaki; Yuichiro Ogura
Tags: choroidal neovascularization, lasers, rna, small interfering, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3820-3824. doi:https://doi.org/10.1167/iovs.09-5121

Visual Neuroscience

Histamine Reduces Flash Sensitivity of ON Ganglion Cells in the Primate Retina Free
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Nikolay P. Akimov; David W. Marshak; Laura J. Frishman; Randolph D. Glickman; Rafail G. Yusupov
Tags: ganglia, histamine, retina, primates
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3825-3834. doi:https://doi.org/10.1167/iovs.09-4806

Visual Psychophysics and Physiological Optics

Neural Compensation for Long-term Asymmetric Optical Blur to Improve Visual Performance in Keratoconic Eyes Free
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Ramkumar Sabesan; Geunyoung Yoon
Tags: eye, optics
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3835-3839. doi:https://doi.org/10.1167/iovs.09-4558

Clinical Trials

Fluorophotometric Study of the Effect of the Glaukos Trabecular Microbypass Stent on Aqueous Humor Dynamics Free
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Yolanda Fernández-Barrientos; Julian García-Feijoó; Jose M. Martínez-de-la-Casa; Luis E. Pablo; Cristina Fernández-Pérez; Julian García Sánchez
Tags: aqueous humor, cataract surgery, intraocular pressure, stents, surgical procedures, operative
Investigative Ophthalmology & Visual Science July 2010, Vol.51, 3327-3332. doi:https://doi.org/10.1167/iovs.09-3972
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