Volume 51 Issue 9 | IOVS

Genetic Deletion of the Adenosine A_2A Receptor Confers Postnatal Development of Relative Myopia in Mice Free

Xiangtian Zhou; Qinzhu Huang; Jianhong An; Runxia Lu; Xiaoyi Qin; Liqin Jiang; Yuan Li; Jianhua Wang; Jiangfan Chen; Jia Qu

Tags: adenosine, collagen, mice, myopia, genetics

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4362-4370. doi:https://doi.org/10.1167/iovs.09-3998

Biochemistry and Molecular Biology

The Pathogenic Role of the Canonical Wnt Pathway in Age-Related Macular Degeneration Free

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Ti Zhou; Yang Hu; Ying Chen; Kevin K. Zhou; Bin Zhang; Guoquan Gao; Jian-xing Ma

Tags: adenovirus infections, age-related macular degeneration, inflammation, proteins, tumor necrosis factors

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4371-4379. doi:https://doi.org/10.1167/iovs.09-4278

Identification of the IRXB Gene Cluster as Candidate Genes in Severe Dysgenesis of the Ocular Anterior Segment Free

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Myriam Chaabouni; Heather Etchevers; Marie Christine De Blois; Patrick Calvas; Marie Christine Waill-Perrier; Michel Vekemans; Serge Pierrick Romana

Tags: candidate disease gene, congenital abnormality, gene clusters, genes, translocation (genetics)

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4380-4386. doi:https://doi.org/10.1167/iovs.09-4111

Novel Null Mutations in the EYS Gene Are a Frequent Cause of Autosomal Recessive Retinitis Pigmentosa in the Israeli Population Free

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Dikla Bandah-Rozenfeld; Karin W. Littink; Tamar Ben-Yosef; Tim M. Strom; Itay Chowers; Rob W. J. Collin; Anneke I. den Hollander; L. Ingeborgh van den Born; Marijke N. Zonneveld; Saul Merin; Eyal Banin; Frans P. M. Cremers; Dror Sharon

Tags: autosomal recessive inheritance, genes, mutation, retinitis pigmentosa

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4387-4394. doi:https://doi.org/10.1167/iovs.09-4732

Mechanism for Carbachol-Induced Secretion of Lacritin in Cultured Monkey Lacrimal Acinar Cells Free

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Ayumi Morimoto-Tochigi; Ryan D. Walkup; Emi Nakajima; Thomas R. Shearer; Mitsuyoshi Azuma

Tags: acinar cells, bodily secretions, cercopithecidae, proteins, carbachol

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4395-4406. doi:https://doi.org/10.1167/iovs.09-4573

Deciphering the Structure and Function of Als2cr4 in the Mouse Retina Free

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Freddi I. Zuniga; Cheryl M. Craft

Tags: mice, proteins, retina, antibodies, photoreceptors

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4407-4415. doi:https://doi.org/10.1167/iovs.10-5251

Metabolic Fingerprints of Proliferative Diabetic Retinopathy: An ¹H-NMR–Based Metabonomic Approach Using Vitreous Humor Free

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Ignasi Barba; Marta Garcia-Ramírez; Cristina Hernández; María Angeles Alonso; Lluis Masmiquel; David García-Dorado; Rafael Simó

Tags: fingerprints, metabolites, proliferative diabetic retinopathy, vitreous body, ascorbic acid

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4416-4421. doi:https://doi.org/10.1167/iovs.10-5348

Retinal Sphingolipids and Their Very-Long-Chain Fatty Acid–Containing Species Free

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Richard S. Brush; Julie-Thu A. Tran; Kimberly R. Henry; Mark E. McClellan; Michael H. Elliott; Md Nawajes A. Mandal

Tags: fatty acids, retina, sphingolipids, lipids, body tissue

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4422-4431. doi:https://doi.org/10.1167/iovs.09-5134

Single-Nucleotide Polymorphisms in the Promoter Region of Matrix Metalloproteinase-1, -2, and -3 in Japanese with High Myopia Free

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Hideo Nakanishi; Hisako Hayashi; Ryo Yamada; Kenji Yamashiro; Isao Nakata; Noriaki Shimada; Kyoko Ohno-Matsui; Manabu Mochizuki; Mineo Ozaki; Shin Yoshitake; Shoji Kuriyama; Masaaki Saito; Tomohiro Iida; Keitaro Matsuo; Fumihiko Matsuda; Nagahisa Yoshimura

Tags: interstitial collagenase, japanese, myopia, promoter regions (genetics), single nucleotide polymorphism

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4432-4436. doi:https://doi.org/10.1167/iovs.09-4871

Altered Ferritin Subunit Composition: Change in Iron Metabolism in Lens Epithelial Cells and Downstream Effects on Glutathione Levels and VEGF Secretion Free

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Jill Harned; Jenny Ferrell; Marilyn M. Lall; Lloyd N. Fleisher; Steven Nagar; Małgorzata Goralska; M. Christine McGahan

Tags: ferritin, iron, vascular endothelial growth factor a

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4437-4446. doi:https://doi.org/10.1167/iovs.09-3861

G/R 241 Polymorphism of Intercellular Adhesion Molecule 1 (ICAM-1) Is Associated with Fuchs Uveitis Free

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Luca Cimino; Luigi Boiardi; Raffaella Aldigeri; Bruno Casali; Davide Nicoli; Enrico Farnetti; Carlo Salvarani; Daniele Cirone; Liberatina De Martino; Alessandro Pupino; Luca Cappuccini

Tags: intercellular adhesion molecule 1, polymorphism, uveitis

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4447-4450. doi:https://doi.org/10.1167/iovs.09-4669

Clinical and Epidemiologic Research

Regional Macular Light Sensitivity Changes in Myopic Chinese Adults: An MP1 Study Free

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Yaowu Qin; Mengjun Zhu; Xiaomei Qu; Gezhi Xu; Yongfu Yu; Rachel E. Witt; Wenji Wang

Tags: adult, chinese (other dialects), chinese people, myopia, photophobia

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4451-4457. doi:https://doi.org/10.1167/iovs.09-4642

C-reactive Protein, Body Mass Index, and Diabetic Retinopathy Free

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Laurence Shen Lim; E. Shyong Tai; Paul Mitchell; Jie Jin Wang; Wan Ting Tay; Ecosse Lamoureux; Tien Yin Wong

Tags: body mass index procedure, c-reactive protein, diabetic retinopathy, diabetes mellitus, diabetes mellitus, type 2

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4458-4463. doi:https://doi.org/10.1167/iovs.09-4939

Genotype-Phenotype Correlation in Ocular von Hippel-Lindau (VHL) Disease: The Effect of Missense Mutation Position on Ocular VHL Phenotype Free

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Pradeep Mettu; Elvira Agrón; Sonia Samtani; Emily Y. Chew; Wai T. Wong

Tags: missense mutation, phenotype, von hippel-lindau syndrome, genotype

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4464-4470. doi:https://doi.org/10.1167/iovs.10-5223

Influence of OCT Signal Strength on Macular, Optic Nerve Head, and Retinal Nerve Fiber Layer Parameters Free

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Chameen Samarawickrama; Amy Pai; Son C. Huynh; George Burlutsky; Tien Y. Wong; Paul Mitchell

Tags: optic disk, retinal nerve fiber layer, optical coherence tomography

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4471-4475. doi:https://doi.org/10.1167/iovs.09-3892

Genetic Association of Insulin-like Growth Factor-1 Polymorphisms with High-Grade Myopia in an International Family Cohort Free

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Ravikanth Metlapally; Chang-Seok Ki; Yi-Ju Li; Khanh-Nhat Tran-Viet; Diana Abbott; Francois Malecaze; Patrick Calvas; David A. Mackey; Thomas Rosenberg; Sandrine Paget; Jeremy A. Guggenheim; Terri L. Young

Tags: cohort studies, family, genetics, insulin-like growth factor i, myopia

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4476-4479. doi:https://doi.org/10.1167/iovs.09-4912

Cornea

Automated Software Analysis of Corneal Micrographs for Peripheral Neuropathy Free

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Timothy J. Holmes; Marco Pellegrini; Clayton Miller; Thomas Epplin-Zapf; Sean Larkin; Saverio Luccarelli; Giovanni Staurenghi

Tags: cornea, neuropathy, peripheral neuropathy, risk factors, software

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4480-4491. doi:https://doi.org/10.1167/iovs.09-4108

Quantitative Analysis of the Effects of Extracellular Matrix Proteins on Membrane Dynamics Associated with Corneal Epithelial Cell Motility Free

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Kazuhiro Kimura; Sumihiro Kawano; Takeshi Mori; Jun Inoue; Hirotaka Hadachi; Takashi Saito; Teruo Nishida

Tags: cell motility, corneal epithelial cells, extracellular matrix proteins, fibronectins, laminin

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4492-4499. doi:https://doi.org/10.1167/iovs.09-4380

Proteomic Analysis of Potential Keratan Sulfate, Chondroitin Sulfate A, and Hyaluronic Acid Molecular Interactions Free

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Abigail H. Conrad; Yuntao Zhang; Elena S. Tasheva; Gary W. Conrad

Tags: binding (molecular function), keratan sulfate, proteins, hyaluronic acid, chondroitin sulfates

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4500-4515. doi:https://doi.org/10.1167/iovs.09-4914

Selective Changes in Human Corneal Sensation Associated with Herpes Simplex Virus Keratitis Free

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Juana Gallar; Timo M. T. Tervo; Waldir Neira; Juha M. Holopainen; Maria E. Lamberg; Fernando Miñana; M. Carmen Acosta; Carlos Belmonte

Tags: cold sensation, common cold, cornea, keratitis, sensory perception

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4516-4522. doi:https://doi.org/10.1167/iovs.10-5225

Lattice Corneal Dystrophy Type IV (p.Leu527Arg) Is Caused by a Founder Mutation of the TGFBI Gene in a Single Japanese Ancestor Free

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Hideki Fukuoka; Satoshi Kawasaki; Kenta Yamasaki; Akira Matsuda; Akiko Fukumoto; Akira Murakami; Shigeru Kinoshita

Tags: genes, japanese, meretoja syndrome, mutation, haplotypes

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4523-4530. doi:https://doi.org/10.1167/iovs.10-5343

A Quantitative Rabbit Model of Vaccinia Keratitis Free

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Sharon Altmann; Andrew Emanuel; Megan Toomey; Kim McIntyre; Jill Covert; Richard Redd Dubielzig; Gary Leatherberry; Christopher J. Murphy; Shantha Kodihalli; Curtis R. Brandt

Tags: eye, keratitis, oryctolagus cuniculus, vaccinia, viruses

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4531-4540. doi:https://doi.org/10.1167/iovs.09-5106

Kinetics of Immune Cell Infiltration in Vaccinia Virus Keratitis Free

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Sharon Altmann; Megan Toomey; Brittany Nesbit; Kim McIntyre; Jill Covert; Richard Redd Dubielzig; Gary Leatherberry; Elizabeth Adkins; Christopher J. Murphy; Curtis R. Brandt

Tags: b-lymphocytes, cornea, eye, infections, keratitis

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4541-4548. doi:https://doi.org/10.1167/iovs.09-5107

The Role of crumbs Genes in the Vertebrate Cornea Free

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Jill Beyer; Xinping C. Zhao; Richard Yee; Shagufta Khaliq; Timothy T. McMahon; Hongyu Ying; Beatrice Y. J. T. Yue; Jarema J. Malicki

Tags: cornea, genes, vertebrates, mutation, zebrafish

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4549-4556. doi:https://doi.org/10.1167/iovs.09-4549

Tear Osmolarity as a Biomarker for Dry Eye Disease Severity Free

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Mari Suzuki; Morgan L. Massingale; Fen Ye; James Godbold; Tali Elfassy; Maithreyi Vallabhajosyula; Penny A. Asbell

Tags: biological markers, dry eye syndromes, osmolar concentration

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4557-4561. doi:https://doi.org/10.1167/iovs.09-4596

Monoallelic Expression of Krt12 Gene during Corneal-type Epithelium Differentiation of Limbal Stem Cells Free

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Yasuhito Hayashi; Mindy K. Call; Chia-Yang Liu; Miyuki Hayashi; George Babcock; Yuichi Ohashi; Winston W.-Y. Kao

Tags: alleles, cornea, epithelium, genes, mice

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4562-4568. doi:https://doi.org/10.1167/iovs.10-5331

The Inhibitory Effects of Bevacizumab Eye Drops on NGF Expression and Corneal Wound Healing in Rats Free

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Eun Chul Kim; Weon Sun Lee; Man Soo Kim

Tags: bevacizumab, cornea, eyedrops, rats, vascular endothelial growth factor a

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4569-4573. doi:https://doi.org/10.1167/iovs.09-4937

Corneal Involvement in Graves' Orbitopathy: An In Vivo Confocal Study Free

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Edoardo Villani; Francesco Viola; Roberto Sala; Mario Salvi; Chiara Mapelli; Nicola Currò; Guia Vannucchi; Paolo Beck-Peccoz; Roberto Ratiglia

Tags: cornea, dry eye syndromes, microscopy, confocal, inflammation, lysergic acid diethylamide

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4574-4578. doi:https://doi.org/10.1167/iovs.10-5380

Swelling of the Human Cornea Revealed by High-Speed, Ultrahigh-Resolution Optical Coherence Tomography Free

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Natalie Hutchings; Trefford L. Simpson; Chulho Hyun; Alireza A. Moayed; Sepideh Hariri; Luigina Sorbara; Kostadinka Bizheva

Tags: cornea, edema, optical coherence tomography, hypoxia, epithelium

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4579-4584. doi:https://doi.org/10.1167/iovs.09-4676

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Effect of Bevacizumab on Strabismus Surgery in Rabbits Free

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Hee Young Choi; Jung Hoon Lee; Ji Eun Lee; Jae Ho Jung

Tags: bevacizumab, fibrosis, oryctolagus cuniculus, strabismus, surgical procedures, operative

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4585-4588. doi:https://doi.org/10.1167/iovs.09-5066

Effect of Bevacizumab on Strabismus Surgery in Rabbits Free

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Hee Young Choi; Jung Hoon Lee; Ji Eun Lee; Jae Ho Jung

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4585-4588. doi:https://doi.org/10.1167/iovs.09-5066

Identification of the Neuromuscular Junction Transcriptome of Extraocular Muscle by Laser Capture Microdissection Free

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Caroline Ketterer; Ulrike Zeiger; Murat T. Budak; Neal A. Rubinstein; Tejvir S. Khurana

Tags: gene expression profiling, genes, laser capture microdissection, muscle of orbit, neuromuscular junction

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4589-4599. doi:https://doi.org/10.1167/iovs.09-4893

Evidence of an Asymmetrical Endophenotype in Congenital Fibrosis of Extraocular Muscles Type 3 Resulting from TUBB3 Mutations Free

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Joseph L. Demer; Robert A. Clark; Max A. Tischfield; Elizabeth C. Engle

Tags: amino acid substitution, congenital fibrosis of the extraocular muscles, endophenotypes, eye, eyelid ptosis

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4600-4611. doi:https://doi.org/10.1167/iovs.10-5438

Compartmentalized Innervation of Primate Lateral Rectus Muscle Free

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Michelle Peng; Vadims Poukens; Roberta Martins da Silva Costa; Lawrence Yoo; Lawrence Tychsen; Joseph L. Demer

Tags: cercopithecidae, lateral rectus muscle, nerve supply, primates, reconstructive surgical procedures

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4612-4617. doi:https://doi.org/10.1167/iovs.10-5330

Glaucoma

Reduced Expression of Aquaporin-9 in Rat Optic Nerve Head and Retina following Elevated Intraocular Pressure Free

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Maiko Naka; Akiyasu Kanamori; Akira Negi; Makoto Nakamura

Tags: optic disk, raised intraocular pressure, retina, water channels, intraocular pressure

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4618-4626. doi:https://doi.org/10.1167/iovs.09-4712

Functional MRI Signal Changes in Primary Visual Cortex Corresponding to the Central Normal Visual Field of Patients with Primary Open-Angle Glaucoma Free

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Guoping Qing; Shaodan Zhang; Bo Wang; Ningli Wang

Tags: functional magnetic resonance imaging, glaucoma, open-angle glaucoma, primary visual cortex, visual fields

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4627-4634. doi:https://doi.org/10.1167/iovs.09-4834

Time Course Changes of Oxidative Stress Markers in a Rat Experimental Glaucoma Model Free

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Sandra M. Ferreira; S. Fabián Lerner; Ricardo Brunzini; Claudia G. Reides; Pablo A. Evelson; Susana F. Llesuy

Tags: glaucoma, oxidative stress, time factors, antioxidants, chemiluminescence

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4635-4640. doi:https://doi.org/10.1167/iovs.09-5044

In Vivo Real-Time Intraocular Pressure Variations during LASIK Flap Creation Free

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Shyam S. Chaurasia; Federico Luengo Gimeno; Kim Tan; Shangjuan Yu; Donald T. Tan; Roger W. Beuerman; Jodhbir S. Mehta

Tags: intraocular pressure, keratomileusis, laser in situ, surgical flaps, 5-lipoxygenase-activating protein, femtosecond pulsed lasers

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4641-4645. doi:https://doi.org/10.1167/iovs.10-5228

Structure–Function Relationship and Diagnostic Value of Macular Ganglion Cell Complex Measurement Using Fourier-Domain OCT in Glaucoma Free

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Na Rae Kim; Eun Suk Lee; Gong Je Seong; Ji Hyun Kim; Hyong Gin An; Chan Yun Kim

Tags: glaucoma, retinal nerve fiber layer, ganglia

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4646-4651. doi:https://doi.org/10.1167/iovs.09-5053

Immunology and Microbiology

The Expression of Intercellular Adhesion Molecule-1 Induced by CD40-CD40L Ligand Signaling in Orbital Fibroblasts in Patients with Graves' Ophthalmopathy Free

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Li-Quan Zhao; Rui-Li Wei; Jin-Wei Cheng; Ji-Ping Cai; You Li

Tags: cd40 antigens, cd40 ligand, fibroblasts, intercellular adhesion molecule 1, graves' ophthalmopathy

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4652-4660. doi:https://doi.org/10.1167/iovs.09-3789

Regulatory Effect of γδ T Cells on IL-17⁺ Uveitogenic T Cells Free

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Hong Nian; Hui Shao; Guoming Zhang; Willi K. Born; Rebecca L. O'Brien; Henry J. Kaplan; Deming Sun

Tags: immunization, interleukin-17, mice, t-lymphocytes, antibodies

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4661-4667. doi:https://doi.org/10.1167/iovs.09-5045

The RIM101 Signal Transduction Pathway Regulates Candida albicans Virulence during Experimental Keratomycosis Free

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Xiaoyong Yuan; Bradley M. Mitchell; Xia Hua; Dana A. Davis; Kirk R. Wilhelmus

Tags: candida albicans, cornea, signal transduction pathways, virulence, suidae

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4668-4676. doi:https://doi.org/10.1167/iovs.09-4726

Localization and Gene Expression of Human β-Defensin 9 at the Human Ocular Surface Epithelium Free

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Imran Mohammed; Hanif Suleman; Ahmad M. Otri; Bina B. Kulkarni; Peng Chen; Andrew Hopkinson; Harminder S. Dua

Tags: defensins, epithelium, gene expression, rna, messenger, proteins

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4677-4682. doi:https://doi.org/10.1167/iovs.10-5334

A Peptide Inhibitor of c-Jun N-Terminal Kinase for the Treatment of Endotoxin-Induced Uveitis Free

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Elodie Touchard; Samy Omri; Marie-Christine Naud; Marianne Berdugo; Catherine Deloche; Claire Abadie; Laurent Jonet; Jean-Claude Jeanny; Patricia Crisanti; Yvonne de Kozak; Jean-Marc Combette; Francine Behar-Cohen

Tags: body tissue, chemokines, cytokine, endotoxins, eye

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4683-4693. doi:https://doi.org/10.1167/iovs.09-4733

Choroidal Neovascularization Enhanced by Chlamydia pneumoniae via Toll-like Receptor 2 in the Retinal Pigment Epithelium Free

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Takeshi Fujimoto; Koh-Hei Sonoda; Kuniaki Hijioka; Kohta Sato; Atsunobu Takeda; Eiichi Hasegawa; Yuji Oshima; Tatsuro Ishibashi

Tags: antigens, choroidal neovascularization, mice, retinal pigment cell, toll-like receptor 2

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4694-4702. doi:https://doi.org/10.1167/iovs.09-4464

Effect of High versus Low Oral Doses of Valacyclovir on Herpes Simplex Virus-1 DNA Shedding into Tears of Latently Infected Rabbits Free

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Manish Kumar; Herbert E. Kaufman; Christian Clement; Partha S. Bhattacharjee; Tashfin S. Huq; Emily D. Varnell; Hilary W. Thompson; James M. Hill

Tags: dna, herpes simplex infection, oryctolagus cuniculus, valacyclovir, viruses

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4703-4706. doi:https://doi.org/10.1167/iovs.09-4884

Lens

Effects of Nuclear Factor-κB Small Interfering RNA on Posterior Capsule Opacification Free

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Hae-Young Lopilly Park; In-Tae Kim; Kyung-Min Lee; Jun-Sub Choi; Myung-Ok Park; Choun-Ki Joo

Tags: rna, small interfering, after-cataract

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4707-4715. doi:https://doi.org/10.1167/iovs.09-4984

An ADAMTS17 Splice Donor Site Mutation in Dogs with Primary Lens Luxation Free

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Fabiana H. G. Farias; Gary S. Johnson; Jeremy F. Taylor; Elizabeth Giuliano; Martin L. Katz; Douglas N. Sanders; Robert D. Schnabel; Stephanie D. McKay; Shahnawaz Khan; Puya Gharahkhani; Caroline A. O'Leary; Louise Pettitt; Oliver P. Forman; Mike Boursnell; Bryan McLaughlin; Saija Ahonen; Hannes Lohi; Elena Hernandez-Merino; David J. Gould; David R. Sargan; Cathryn Mellersh

Tags: dog, domestic, donor site, lens (device), lens, crystalline, mutation

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4716-4721. doi:https://doi.org/10.1167/iovs.09-5142

Physiology and Pharmacology

An Agonistic TrkB mAb Causes Sustained TrkB Activation, Delays RGC Death, and Protects the Retinal Structure in Optic Nerve Axotomy and in Glaucoma Free

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Yujing Bai; Jing Xu; Fouad Brahimi; Yehong Zhuo; Marinko V. Sarunic; H. Uri Saragovi

Tags: axotomy, glaucoma, monoclonal antibodies, neurotrophic tyrosine kinase receptor type 2, retina

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4722-4731. doi:https://doi.org/10.1167/iovs.09-5032

Retina

Polymorphisms of the DNA Repair Genes XPD and XRCC1 and the Risk of Age-Related Macular Degeneration Free

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Ebru Görgün; Mehmet Güven; Mustafa Ünal; Bahadır Batar; Gülgün S. Güven; Melda Yenerel; Sinan Tatlıpınar; Mehmet Seven; Adnan Yüksel

Tags: age-related macular degeneration, dna repair gene, ercc2 gene, polymorphism, xrcc1 gene

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4732-4737. doi:https://doi.org/10.1167/iovs.09-4842

Relative Contribution of VEGF and TNF-α in the Cynomolgus Laser-Induced CNV Model: Comparing the Efficacy of Bevacizumab, Adalimumab, and ESBA105 Free

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Peter Lichtlen; Tim T. Lam; T. Michael Nork; Tim Streit; David M. Urech

Tags: adalimumab, bevacizumab, choroidal neovascularization, lasers, tumor necrosis factors

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4738-4745. doi:https://doi.org/10.1167/iovs.09-4890

Methyl Palmitate: A Potent Vasodilator Released in the Retina Free

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Yuan-Chieh Lee; Hsi-Hsien Chang; Chin-Hung Liu; Mei-Fang Chen; Po-Yi Chen; Jon-Son Kuo; Tony J.-F. Lee

Tags: aorta, palmitates, retina, vasodilators, hexanes

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4746-4753. doi:https://doi.org/10.1167/iovs.09-5132

Evaluation of Macular Structure and Function by OCT and Electrophysiology in Patients with Vitelliform Macular Dystrophy Due to Mutations in BEST1 Free

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Patrik Schatz; Hanna Bitner; Birgit Sander; Stig Holfort; Sten Andreasson; Michael Larsen; Dror Sharon

Tags: family, mutation, vitelliform dystrophy, electrophysiology, heterozygote

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4754-4765. doi:https://doi.org/10.1167/iovs.10-5152

Retinal Tissue Oxygen Tension Imaging in the Rat Free

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Mahnaz Shahidi; Justin Wanek; Norman P. Blair; Deborah M. Little; Tingting Wu

Tags: arterial oxygen tension, body tissue, diagnostic imaging, oxygen, retina

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4766-4770. doi:https://doi.org/10.1167/iovs.09-4710

The PROM1 Mutation p.R373C Causes an Autosomal Dominant Bull's Eye Maculopathy Associated with Rod, Rod–Cone, and Macular Dystrophy Free

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Michel Michaelides; Marie-Claire Gaillard; Pascal Escher; Leila Tiab; Matthew Bedell; François-Xavier Borruat; Daniel Barthelmes; Ruben Carmona; Kang Zhang; Edward White; Michelle McClements; Anthony G. Robson; Graham E. Holder; Keith Bradshaw; David M. Hunt; Andrew R. Webster; Anthony T. Moore; Daniel F. Schorderet; Francis L. Munier

Tags: eye, family, macular disorders, macular dystrophy, mutation

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4771-4780. doi:https://doi.org/10.1167/iovs.09-4561

Epidemiology of Giant Retinal Tears in the United Kingdom: The British Giant Retinal Tear Epidemiology Eye Study (BGEES) Free

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Ghee Soon Ang; John Townend; Noemi Lois

Tags: epidemiology, eye, retinal perforations, incidence

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4781-4787. doi:https://doi.org/10.1167/iovs.09-5036

Reproducibility of Macular Thickness Measurements Using Cirrus SD-OCT in Neovascular Age-Related Macular Degeneration Free

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Mariacristina Parravano; Francesco Oddone; Barbara Boccassini; Francesca Menchini; Adele Chiaravalloti; Mauro Schiavone; Monica Varano

Tags: exudative age-related macular degeneration, artifacts

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4788-4791. doi:https://doi.org/10.1167/iovs.09-4976

Ocular Hemorrhages in Neonatal Porcine Eyes from Single, Rapid Rotational Events Free

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Brittany Coats; Gil Binenbaum; Robert L. Peiffer; Brian J. Forbes; Susan S. Margulies

Tags: eye, eye hemorrhage, hemorrhage, newborn, suidae

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4792-4797. doi:https://doi.org/10.1167/iovs.10-5211

Retinal Cell Biology

Retinal Protection from Acute Glaucoma-Induced Ischemia-Reperfusion Injury through Pharmacologic Induction of Heme Oxygenase-1 Free

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Ming-Hui Sun; Jong-Hwei Su Pang; Show-Li Chen; Wen-Hua Han; Tsung-Chuan Ho; Kuan-Jen Chen; Ling-Yuh Kao; Ken-Kuo Lin; Yeou-Ping Tsao

Tags: cyclophosphamide/prednisone/procarbazine/vincristine, reperfusion injury, retina, proteins, ischemia

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4798-4808. doi:https://doi.org/10.1167/iovs.09-4086

Altered Expression of Metallothionein-I and -II and Their Receptor Megalin in Inherited Photoreceptor Degeneration Free

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Kirsten A. Wunderlich; Thierry Leveillard; Milena Penkowa; Eberhart Zrenner; Maria-Thereza Perez

Tags: ldl-receptor related protein 2, metallothionein, mice, photoreceptors, retina

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4809-4820. doi:https://doi.org/10.1167/iovs.09-5073

Environmental Damage to the Retina and Preconditioning: Contrasting Effects of Light and Hyperoxic Stress Free

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Yuan Zhu; Krisztina Valter; Jonathan Stone

Tags: hyperoxia, retina, stress, photoreceptors, mice, inbred c57bl

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4821-4830. doi:https://doi.org/10.1167/iovs.09-5050

Conditions of Retinal Glial and Inflammatory Cell Activation after Irradiation in a GFP-Chimeric Mouse Model Free

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Philipp S. Müther; Irina Semkova; Kristina Schmidt; Elizabeth Abari; Marc Kuebbeler; Marc Beyer; Hinrich Abken; Klaus L. Meyer; Norbert Kociok; Antonia M. Joussen

Tags: body tissue, bone marrow, chimera organism, choroidal neovascularization, inflammatory cells

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4831-4839. doi:https://doi.org/10.1167/iovs.09-4923

Postnatal Development and Functional Adaptations of the Melanopsin Photoreceptive System in the Albino Mouse Retina Free

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Irene González-Menéndez; Felipe Contreras; Rafael Cernuda-Cernuda; Ignacio Provencio; José M. García-Fernández

Tags: albinism, melanopsin, mice, retina

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4840-4847. doi:https://doi.org/10.1167/iovs.10-5253

VEGF Antagonists Decrease Barrier Function of Retinal Pigment Epithelium In Vitro: Possible Participation of Intracellular Glutathione Free

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Yoko Miura; Alexa Klettner; Johann Roider

Tags: antagonists, bevacizumab, glutathione, ranibizumab, vascular endothelial growth factor a

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4848-4855. doi:https://doi.org/10.1167/iovs.09-4699

Visual Neuroscience

Absolute Quantification of Oxygenated Hemoglobin within the Visual Cortex with Functional Near Infrared Spectroscopy (fNIRS) Free

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Michelle A. McIntosh; Uma Shahani; Richard G. Boulton; Daphne L. McCulloch

Tags: hemoglobin, hyperbaric oxygenation, mass or substance concentration per volume, spectroscopy, near-infrared, visual cortex

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4856-4860. doi:https://doi.org/10.1167/iovs.09-4940

Visual Psychophysics and Physiological Optics

The Effect of Presbyopic Vision Corrections on Nighttime Driving Performance Free

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Byoung Sun Chu; Joanne M. Wood; Michael J. Collins

Tags: vision

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4861-4866. doi:https://doi.org/10.1167/iovs.10-5154

Clinical Trials

Intravitreal Bevacizumab for Subfoveal Choroidal Neovascularization Associated with Pattern Dystrophy Free

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Maurizio Battaglia Parodi; Pierluigi Iacono; Marialucia Cascavilla; Ilaria Zucchiatti; Dimitrios Stylianos Kontadakis; Francesco Bandello

Tags: bevacizumab, choroidal neovascularization, follow-up

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4358-4361. doi:https://doi.org/10.1167/iovs.10-5237

Perspective

Interpretations of Fundus Autofluorescence from Studies of the Bisretinoids of the Retina Free

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Janet R. Sparrow; Kee Dong Yoon; Yalin Wu; Kazunori Yamamoto

Tags: fundus autofluorescence imaging, lipofuscin, retina, autofluorescence, photoreceptors

Investigative Ophthalmology & Visual Science September 2010, Vol.51, 4351-4357. doi:https://doi.org/10.1167/iovs.10-5852

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