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Anatomy and Pathology/Oncology

Detection of M2-Macrophages in Uveal Melanoma and Relation with Survival Free
PDF
Inge H. G. Bronkhorst; Long V. Ly; Ekaterina S. Jordanova; Johannes Vrolijk; Mieke Versluis; Gregorius P. M. Luyten; Martine J. Jager
Tags: cd68 antigen, human, macrophages, uveal melanoma, neoplasms
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 643-650. doi:https://doi.org/10.1167/iovs.10-5979
Changes in Cholinergic Amacrine Cells after Rodent Anterior Ischemic Optic Neuropathy (rAION) Free
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Steven L. Bernstein; Yan Guo
Tags: amacrine cells, anterior ischemic optic neuropathy, cholinergic agents, khat, retina
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 904-910. doi:https://doi.org/10.1167/iovs.10-5247

Biochemistry and Molecular Biology

A Novel Role for the Immunoproteasome in Retinal Function Free
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Stacy A. Hussong; Heidi Roehrich; Rebecca J. Kapphahn; Marcela Maldonado; Machelle T. Pardue; Deborah A. Ferrington
Tags: electroretinography, language morphology, mice, morphology, proteins
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 714-723. doi:https://doi.org/10.1167/iovs.10-6032
Efficient In Vivo Doxycycline and Cre Recombinase–Mediated Inducible Transgene Activation in the Murine Trabecular Meshwork Free
PDF
Pu Liu; Xueyao Fu; Randy L. Johnson
Tags: doxycycline, mice, myoc gene, tamoxifen, trabecular meshwork
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 969-974. doi:https://doi.org/10.1167/iovs.09-5052

Clinical and Epidemiologic Research

The Relationship between Retinal Arteriolar and Venular Calibers Is Genetically Mediated, and Each Is Associated with Risk of Cardiovascular Disease Free
PDF
Samantha J. Fahy; Cong Sun; Gu Zhu; Paul R. Healey; Tim D. Spector; Nicolas G. Martin; Paul Mitchell; Tien Y. Wong; David A. Mackey; Christopher J. Hammond; Toby Andrew
Tags: genetics, heart disease risk factors, risk factors, twins, phenotype
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 975-981. doi:https://doi.org/10.1167/iovs.10-5927
Changes in Retinal Sensitivity in Geographic Atrophy Progression as Measured by Microperimetry Free
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Annal D. Meleth; Pradeep Mettu; Elvira Agrón; Emily Y. Chew; Srinivas R. Sadda; Frederick L. Ferris; Wai T. Wong
Tags: atrophy, eye, diagnostic imaging, follow-up
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 1119-1126. doi:https://doi.org/10.1167/iovs.10-6075

Cornea

Biosynthetic Corneal Implants for Replacement of Pathologic Corneal Tissue: Performance in a Controlled Rabbit Alkali Burn Model Free
PDF
Joanne M. Hackett; Neil Lagali; Kimberley Merrett; Henry Edelhauser; Yifei Sun; Lisha Gan; May Griffith; Per Fagerholm
Tags: alkalies, body tissue, burns, cornea, corneal implant
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 651-657. doi:https://doi.org/10.1167/iovs.10-5224
Adhesion, Migration, and Proliferation of Cultured Human Corneal Endothelial Cells by Laminin-5 Free
PDF
Masahiro Yamaguchi; Nobuyuki Ebihara; Nobuyuki Shima; Miwa Kimoto; Toshinari Funaki; Seiichi Yokoo; Akira Murakami; Satoru Yamagami
Tags: adhesions, cornea, endothelial cells, laminin
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 679-684. doi:https://doi.org/10.1167/iovs.10-5555
Cell Delivery with Fixed Amniotic Membrane Reconstructs Corneal Epithelium in Rabbits with Limbal Stem Cell Deficiency Free
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Pengxia Wan; Xiaoran Wang; Ping Ma; Nan Gao; Jian Ge; Yonggao Mou; Zhichong Wang
Tags: amnion, cornea, corneal epithelium, limbal stem cell deficiency, oryctolagus cuniculus
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 724-730. doi:https://doi.org/10.1167/iovs.10-5291
Correlation of Corneal Acoustic and Elastic Properties in a Canine Eye Model Free
PDF
Xiaoyin He; Jun Liu
Tags: acoustics, cornea, dog, domestic, eye, sound impedance
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 731-736. doi:https://doi.org/10.1167/iovs.10-5723
Predicting Dry Eye Using Noninvasive Techniques of Tear Film Surface Assessment Free
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Dorota H. Szczesna; David Alonso-Caneiro; D. Robert Iskander; Scott A. Read; Michael J. Collins
Tags: dry eye syndromes, tear film finding
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 751-756. doi:https://doi.org/10.1167/iovs.10-5173
TGFB1-Induced Extracellular Expression of TGFBIp and Inhibition of TGFBIp Expression by RNA Interference in a Human Corneal Epithelial Cell Line Free
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Vivek S. Yellore; Sylvia A. Rayner; Anthony J. Aldave
Tags: corneal epithelial cells, proteins, rna interference, rna, messenger, rna, small interfering
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 757-763. doi:https://doi.org/10.1167/iovs.10-5362
Cytokeratin 8 Is Expressed in Human Corneoconjunctival Epithelium, Particularly in Limbal Epithelial Cells Free
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Stanislava Merjava; Kristyna Brejchova; Amanda Vernon; Julie T. Daniels; Katerina Jirsova
Tags: cornea, cytokeratin 8, epithelial cells, epithelium, fluorescent antibody technique
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 787-794. doi:https://doi.org/10.1167/iovs.10-5489
Three-Dimensional Analysis of Collagen Lamellae in the Anterior Stroma of the Human Cornea Visualized by Second Harmonic Generation Imaging Microscopy Free
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Naoyuki Morishige; Yuki Takagi; Tai-ichiro Chikama; Atsushi Takahara; Teruo Nishida
Tags: collagen, cornea, diagnostic imaging, harmonics, bowman's layer
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 911-915. doi:https://doi.org/10.1167/iovs.10-5657
In Vivo Confocal Microscopy of Meibomian Glands in Sjögren's Syndrome Free
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Edoardo Villani; Silvia Beretta; Michela De Capitani; Daniela Galimberti; Francesco Viola; Roberto Ratiglia
Tags: bodily secretions, meibomian gland, microscopy, confocal, sjogren's syndrome, inflammation
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 933-939. doi:https://doi.org/10.1167/iovs.10-5995
Retinal Point-Spread Function after Corneal Transplantation for Fuchs' Dystrophy Free
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Loren S. Seery; Jay W. McLaren; Katrina M. Kittleson; Sanjay V. Patel
Tags: descemet stripping endothelial keratoplasty, eye, keratoplasty, point spread function, visual acuity
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 1003-1008. doi:https://doi.org/10.1167/iovs.10-5375
Fluorescent In Situ Hybridization (FISH) on Corneal Impression Cytology Specimens (CICS): Study of Epithelial Cell Survival after Keratoplasty Free
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Muriel Catanese; Cornel Popovici; Hélène Proust; Louis Hoffart; Frédéric Matonti; Isabelle Cochereau; John Conrath; Eric E. Gabison
Tags: cornea, cytology, epithelial cells, fluorescent in situ hybridization, keratoplasty
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 1009-1013. doi:https://doi.org/10.1167/iovs.10-5394
Refractive Changes after Descemet Stripping Endothelial Keratoplasty: A Simplified Mathematical Model Free
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Richard Y. Hwang; Daniel J. Gauthier; Dana Wallace; Natalie A. Afshari
Tags: cornea, descemet stripping endothelial keratoplasty, mathematical model, tissue transplants, surgical procedures, operative
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 1043-1054. doi:https://doi.org/10.1167/iovs.10-5839
In Vivo Quantification of Bacterial Keratitis with Optical Coherence Tomography Free
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Aristides Konstantopoulos; Ghasem Yadegarfar; Marina Fievez; David F. Anderson; Parwez Hossain
Tags: bacterial keratitis, optical coherence tomography, cornea, keratitis
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 1093-1097. doi:https://doi.org/10.1167/iovs.10-6067
Tear Film, Contact Lens, and Patient Factors Associated with Corneal Staining Free
PDF
Jason J. Nichols; Loraine T. Sinnott
Tags: contact lenses, cornea, tear film finding, lens (device)
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 1127-1137. doi:https://doi.org/10.1167/iovs.10-5757

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Effect of Stimulus Type on the Eye Movements of Children Free
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Elizabeth L. Irving; Esther G. González; Linda Lillakas; Jonathan Wareham; Tara McCarthy
Tags: child, eye movement, frequency of responses, saccades, velocity
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 658-664. doi:https://doi.org/10.1167/iovs.10-5480
Effects of Anisometropic Amblyopia on Visuomotor Behavior, Part 2: Visually Guided Reaching Free
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Ewa Niechwiej-Szwedo; Herbert C. Goltz; Manokaraananthan Chandrakumar; Zahra Hirji; J. Douglas Crawford; Agnes M. F. Wong
Tags: amblyopia, anisometropic amblyopia, deceleration, precision, eye
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 795-803. doi:https://doi.org/10.1167/iovs.10-6092
Modulating Neuromuscular Junction Density Changes in Botulinum Toxin–Treated Orbicularis Oculi Muscle Free
PDF
Andrew R. Harrison; Zachary Berbos; Renzo A. Zaldivar; Brian C. Anderson; Mollie Semmer; Michael S. Lee; Linda K. McLoon
Tags: botulinum toxins, neuromuscular junction, orbicularis oculi muscle, muscle, botulinum toxins, type a
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 982-986. doi:https://doi.org/10.1167/iovs.10-6427

Glaucoma

Investigation of the Association between Helicobacter pylori Infection and Normal Tension Glaucoma Free
PDF
Joon Mo Kim; Seok Hwan Kim; Ki Ho Park; So Young Han; Hyoung Sub Shim
Tags: helicobacter infections, helicobacter pylori, low tension glaucoma, glaucoma, infections
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 665-668. doi:https://doi.org/10.1167/iovs.10-6096
Assessment of Aqueous Humor Dynamics in the Mouse by a Novel Method of Constant-Flow Infusion Free
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J. Cameron Millar; Abbot F. Clark; Iok-Hou Pang
Tags: aqueous humor, eye, fluid flow, infusion procedures, intraocular pressure
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 685-694. doi:https://doi.org/10.1167/iovs.10-6069
Characteristics of Visual Field Progression in Medically Treated Normal-Tension Glaucoma Patients with Unstable Ocular Perfusion Pressure Free
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Kyung Rim Sung; Jung Woo Cho; Suhwan Lee; Sung-Cheol Yun; Jaewan Choi; Jung Hwa Na; Youngrok Lee; Michael Scott Kook
Tags: eye, follow-up, intraocular pressure, low tension glaucoma, mopp protocol
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 737-743. doi:https://doi.org/10.1167/iovs.10-5351
Responses of Primate Retinal Ganglion Cells to Perimetric Stimuli Free
PDF
William H. Swanson; Hao Sun; Barry B. Lee; Dingcai Cao
Tags: ganglia, microfold cell, nodal myocytes, perimetry, primates
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 764-771. doi:https://doi.org/10.1167/iovs.10-6158
Microstructural Differences in the Human Posterior Sclera as a Function of Age and Race Free
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Dongmei Yan; Sheridan McPheeters; Gregory Johnson; Urs Utzinger; Jonathan P. Vande Geest
Tags: continental population groups, sclera, donors
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 821-829. doi:https://doi.org/10.1167/iovs.09-4651
Calibration of the TonoLab Tonometer in Mice with Spontaneous or Experimental Glaucoma Free
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Mary E. Pease; Frances E. Cone; Scott Gelman; Janice L. Son; Harry A. Quigley
Tags: calibration, glaucoma, intraocular pressure, mice, tonometers
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 858-864. doi:https://doi.org/10.1167/iovs.10-5556
Initial Arcuate Defects within the Central 10 Degrees in Glaucoma Free
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Donald C. Hood; Ali S. Raza; Carlos Gustavo V. de Moraes; Jeffrey G. Odel; Vivienne C. Greenstein; Jeffrey M. Liebmann; Robert Ritch
Tags: glaucoma, retinal nerve fiber layer, eye, scotoma
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 940-946. doi:https://doi.org/10.1167/iovs.10-5803
Novel Heidelberg Retina Tomograph–Based Morphological Parameters Derived from Optic Disc Cupping Surface Processing Free
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Vassilis Kilintzis; Theofanis Pappas; Ioanna Chouvarda; Aggeliki Salonikiou; Nicos Maglaveras; Stavros Dimitrakos; Fotis Topouzis
Tags: cupping therapy, glaucoma, heidelberg retina tomograph, optic disk, cd138
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 947-951. doi:https://doi.org/10.1167/iovs.10-6298
The Influence of Sampling Errors on Test–Retest Variability in Perimetry Free
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Ted Maddess
Tags: perimetry, sampling error, visual fields, scotoma, spatial frequency
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 1014-1022. doi:https://doi.org/10.1167/iovs.10-6014
Quercetin Induces the Expression of Peroxiredoxins 3 and 5 via the Nrf2/NRF1 Transcription Pathway Free
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Naoya Miyamoto; Hiroto Izumi; Rie Miyamoto; Hiroyuki Kondo; Akihiko Tawara; Yasuyuki Sasaguri; Kimitoshi Kohno
Tags: quercetin
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 1055-1063. doi:https://doi.org/10.1167/iovs.10-5777
Assessment of Glaucomatous Changes in Subjects with High Myopia Using Spectral Domain Optical Coherence Tomography Free
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Takuhei Shoji; Hiroki Sato; Masahiro Ishida; Masaru Takeuchi; Etsuo Chihara
Tags: glaucoma, myopia, optical coherence tomography, retinal nerve fiber layer, eye
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 1098-1102. doi:https://doi.org/10.1167/iovs.10-5922
Predictors of Normal Optic Nerve Head, Retinal Nerve Fiber Layer, and Macular Parameters Measured by Spectral Domain Optical Coherence Tomography Free
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Harsha L. Rao; Addepalli U. Kumar; Jonnadula G. Babu; Anjul Kumar; Sirisha Senthil; Chandra S. Garudadri
Tags: optic disk, optical coherence tomography, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 1103-1110. doi:https://doi.org/10.1167/iovs.10-5997
Trend-Based Analysis of Retinal Nerve Fiber Layer Thickness Measured by Optical Coherence Tomography in Eyes with Localized Nerve Fiber Layer Defects Free
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Eun Ji Lee; Tae-Woo Kim; Robert N. Weinreb; Ki Ho Park; Seok Hwan Kim; Dong Myung Kim
Tags: eye, fundus photography, optical coherence tomography, retinal nerve fiber layer, trend
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 1138-1144. doi:https://doi.org/10.1167/iovs.10-5975

Immunology and Microbiology

The Streptococcus pneumoniae Capsule Is Required for Full Virulence in Pneumococcal Endophthalmitis Free
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Melissa E. Sanders; Erin W. Norcross; Zachary M. Robertson; Quincy C. Moore, III; Jonathan Fratkin; Mary E. Marquart
Tags: endophthalmitis, eye, streptococcus pneumoniae, virulence, parent
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 865-872. doi:https://doi.org/10.1167/iovs.10-5513
Detection and Gram Discrimination of Bacterial Pathogens from Aqueous and Vitreous Humor Using Real-Time PCR Assays Free
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Paulo José Martins Bispo; Gustavo Barreto de Melo; Ana Luisa Hofling-Lima; Antonio Carlos Campos Pignatari
Tags: polymerase chain reaction, vitreous body, pathogenic organism, dna
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 873-881. doi:https://doi.org/10.1167/iovs.10-5712
Effect of Artesunate on Endotoxin-Induced Uveitis in Rats Free
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Xiao-Qin Wang; Hai-Lin Liu; Gui-Bo Wang; Peng-Fei Wu; Tian Yan; Jia Xie; Yong Tang; Lu-Kun Sun; Chen Li
Tags: aqueous humor, artesunate, endotoxins, mass or substance concentration per volume, rats
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 916-919. doi:https://doi.org/10.1167/iovs.10-5892

Lens

A Homozygous Microdeletion within ADAMTSL4 in Patients with Isolated Ectopia Lentis: Evidence of a Founder Mutation Free
PDF
Teresa M. Neuhann; Juliane Artelt; Thomas F. Neuhann; Sigrid Tinschert; Andreas Rump
Tags: ectopia lentis, family, homozygote, mutation, polymerase chain reaction
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 695-700. doi:https://doi.org/10.1167/iovs.10-5740
Fatty Acid Uptake and Incorporation into Phospholipids in the Rat Lens Free
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Jessica R. Nealon; Stephen J. Blanksby; Paul J. Donaldson; Roger J. W. Truscott; Todd W. Mitchell
Tags: fatty acids, lens (device), lens, crystalline, phospholipids
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 804-809. doi:https://doi.org/10.1167/iovs.10-5830
Properties of Connexin 46 Hemichannels in Dissociated Lens Fiber Cells Free
PDF
Lisa Ebihara; Jun-Jie Tong; Barbara Vertel; Thomas W. White; Tung-Ling Chen
Tags: gap junction protein, lens (device), lens, crystalline, calcium, mice
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 882-889. doi:https://doi.org/10.1167/iovs.10-6200

Low Vision

Improving Reading Speed for People with Central Vision Loss through Perceptual Learning Free
PDF
Susana T. L. Chung
Tags: blindness, perceptual learning, reading speed, training, visual acuity
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 1164-1170. doi:https://doi.org/10.1167/iovs.10-6034

Physiology and Pharmacology

In Vitro Synergism of Trifluorothymidine and Ganciclovir against HSV-1 Free
PDF
Jeffery A. Hobden; Manish Kumar; Herbert E. Kaufman; Christian Clement; Emily D. Varnell; Partha S. Bhattacharjee; James M. Hill
Tags: acyclovir, antiviral agents, ganciclovir, human herpesvirus 1, trifluridine
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 830-833. doi:https://doi.org/10.1167/iovs.10-5671
Correlations between Parameters of Aqueous Humor Dynamics and the Influence of Central Corneal Thickness Free
PDF
Vikas Gulati; Deepta A. Ghate; Carl B. Camras; Carol B. Toris
Tags: aqueous humor, cornea, fluid flow, intraocular pressure, significance
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 920-926. doi:https://doi.org/10.1167/iovs.10-5494
Effects of Vitreous Liquefaction on the Intravitreal Distribution of Sodium Fluorescein, Fluorescein Dextran, and Fluorescent Microparticles Free
PDF
Lay Ean Tan; Werhner Orilla; Patrick M. Hughes; Susan Tsai; James A. Burke; Clive G. Wilson
Tags: dextran, fluorescein, liquefaction, sodium fluorescein, vitreous body
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 1111-1118. doi:https://doi.org/10.1167/iovs.10-5813

Retina

Influence of Refractive Error and Axial Length on Retinal Vessel Geometric Characteristics Free
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Laurence Shen Lim; Carol Yim-lui Cheung; Xiaoyu Lin; Paul Mitchell; Tien Yin Wong; Seang Mei-Saw
Tags: refractive errors, retinal vessels, retinal vascular caliber
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 669-678. doi:https://doi.org/10.1167/iovs.10-6184
Reduced Choroidal Neovascular Membrane Formation in Cyclooxygenase-2 Null Mice Free
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Kasra A. Rezaei; Hassanain S. Toma; Jiyang Cai; John S. Penn; Paul Sternberg; Stephen J. Kim
Tags: choroidal neovascularization, cyclooxygenase-2, cyclooxygenase-2 inhibitors, lasers, light coagulation
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 701-707. doi:https://doi.org/10.1167/iovs.10-6319
Foveal Structure and Thickness of Retinal Layers Long-Term after Surgical Peeling of Idiopathic Epiretinal Membrane Free
PDF
Felix Treumer; Nina Wacker; Olaf Junge; Jürgen Hedderich; Johann Roider; Jost Hillenkamp
Tags: epiretinal membrane, surgical procedures, operative, eye
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 744-750. doi:https://doi.org/10.1167/iovs.10-6310
Multifocal Electroretinograms Predict Onset of Diabetic Retinopathy in Adult Patients with Diabetes Free
PDF
Wendy W. Harrison; Marcus A. Bearse, Jr; Jason S. Ng; Nicholas P. Jewell; Shirin Barez; Dennis Burger; Marilyn E. Schneck; Anthony J. Adams
Tags: adult, diabetes mellitus, diabetes mellitus, type 2, diabetic retinopathy, electroretinography
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 772-777. doi:https://doi.org/10.1167/iovs.10-5931
Computer-Assisted Methods to Evaluate Retinal Vascular Caliber: What Are They Measuring? Free
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Helena M. Pakter; Sandra C. Fuchs; Marcelo K. Maestri; Leila B. Moreira; Luciana M. Dei Ricardi; Vítor F. Pamplona; Manuel M. Oliveira; Flávio D. Fuchs
Tags: computers, diameter, retinal vascular caliber, retinal vessels, color
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 810-815. doi:https://doi.org/10.1167/iovs.10-5876
IQCB1 Mutations in Patients with Leber Congenital Amaurosis Free
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Alejandro Estrada-Cuzcano; Robert K. Koenekoop; Frauke Coppieters; Susanne Kohl; Irma Lopez; Rob W. J. Collin; Elfride B. W. De Baere; Debbie Roeleveld; Jonah Marek; Antje Bernd; Klaus Rohrschneider; L. Ingeborgh van den Born; Françoise Meire; Irene H. Maumenee; Samuel G. Jacobson; Carel B. Hoyng; Eberhart Zrenner; Frans P. M. Cremers; Anneke I. den Hollander
Tags: leber's amaurosis, mutation, medullary cystic disease
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 834-839. doi:https://doi.org/10.1167/iovs.10-5221
Pilot Study of Optical Coherence Tomography Measurement of Retinal Blood Flow in Retinal and Optic Nerve Diseases Free
PDF
Yimin Wang; Amani A. Fawzi; Rohit Varma; Alfredo A. Sadun; Xinbo Zhang; Ou Tan; Joseph A. Izatt; David Huang
Tags: eye, fluid flow, glaucoma, optic nerve disorders, optical coherence tomography
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 840-845. doi:https://doi.org/10.1167/iovs.10-5985
Effect of Cataract in Evaluation of Macular Pigment Optical Density by Autofluorescence Spectrometry Free
PDF
Yuzuru Sasamoto; Fumi Gomi; Miki Sawa; Hirokazu Sakaguchi; Motokazu Tsujikawa; Kohji Nishida
Tags: autofluorescence, cataract, cataract surgery, optics, pigment
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 927-932. doi:https://doi.org/10.1167/iovs.10-5664
Electrophysiological Consequences of Experimental Branch Retinal Vein Occlusion in Pigs and the Effect of Dorzolamide Free
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Rasmus Ejstrup; Erik Scherfig; Morten la Cour
Tags: dorzolamide, suidae, venous retinal branch occlusion, eye
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 952-958. doi:https://doi.org/10.1167/iovs.10-6110
The Oral Iron Chelator Deferiprone Protects against Iron Overload–Induced Retinal Degeneration Free
PDF
Majda Hadziahmetovic; Ying Song; Natalie Wolkow; Jared Iacovelli; Steven Grieco; Jennifer Lee; Arkady Lyubarsky; Domenico Pratico; John Connelly; Michael Spino; Z. Leah Harris; Joshua L. Dunaief
Tags: deferiprone, iron, iron chelating agents, iron overload, mice
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 959-968. doi:https://doi.org/10.1167/iovs.10-6207
Activated Protein C Rescues the Retina from Ischemia-Induced Cell Death Free
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Zhao-Jiang Du; Takuhiro Yamamoto; Tomoko Ueda; Mihoko Suzuki; Yasuo Tano; Motohiro Kamei
Tags: activated protein c, caspase-3, caspases, cell death, cytotoxicity
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 987-993. doi:https://doi.org/10.1167/iovs.10-5557
Spatial and Spectral Imaging of Retinal Laser Photocoagulation Burns Free
PDF
Mahiul M. K. Muqit; Jonathan Denniss; Vincent Nourrit; George R. Marcellino; David B. Henson; Ingo Schiessl; Paulo E. Stanga
Tags: burns, diagnostic imaging, lasers, light coagulation
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 994-1002. doi:https://doi.org/10.1167/iovs.10-6309
Silicone Oil Microdroplets and Protein Aggregates in Repackaged Bevacizumab and Ranibizumab: Effects of Long-term Storage and Product Mishandling Free
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Lu Liu; David A. Ammar; Lindsey A. Ross; Naresh Mandava; Malik Y. Kahook; John F. Carpenter
Tags: bevacizumab, syringes, ranibizumab, proteins, silicone oils
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 1023-1034. doi:https://doi.org/10.1167/iovs.10-6431
Vitreal Oxygenation in Retinal Ischemia Reperfusion Free
PDF
Walid Abdallah; Hossein Ameri; Ernesto Barron; Gerald J. Chader; Elias Greenbaum; David R. Hinton; Mark S. Humayun
Tags: alveolar ventilation function, cell respiration, eye, ischemia, oxygen
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 1035-1042. doi:https://doi.org/10.1167/iovs.09-4516
Subfoveal Choroidal Blood Flow and Central Retinal Function in Retinitis Pigmentosa Free
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Benedetto Falsini; Gian Mario Anselmi; Dario Marangoni; Fabiana D'Esposito; Antonello Fadda; Antonio Di Renzo; Emilio C. Campos; Charles E. Riva
Tags: retinitis pigmentosa, vascular flow, laser-doppler flowmetry, retinal cone
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 1064-1069. doi:https://doi.org/10.1167/iovs.10-5964
Persons with Age-Related Maculopathy Risk Genotypes and Clinically Normal Eyes Have Reduced Mesopic Vision Free
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Beatrix Feigl; Dingcai Cao; Charles P. Morris; Andrew J. Zele
Tags: age-related macular degeneration, eye, genes, genotype, vision
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 1145-1150. doi:https://doi.org/10.1167/iovs.10-5967
A Three-Pore Model Describes Transport Properties of Bovine Retinal Endothelial Cells in Normal and Elevated Glucose Free
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Sandra V. Lopez-Quintero; Xin-Ying Ji; David A. Antonetti; John M. Tarbell
Tags: biological transport, cattle, dextran, endothelial cells, hyperglycemia
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 1171-1180. doi:https://doi.org/10.1167/iovs.10-5971

Retinal Cell Biology

α2-Macroglobulin Induces Glial Fibrillary Acidic Protein Expression Mediated by Low-Density Lipoprotein Receptor-Related Protein 1 in Müller Cells Free
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Pablo F. Barcelona; Susana G. Ortiz; Gustavo A. Chiabrando; Maria C. Sánchez
Tags: glial fibrillary acidic protein, proteins, macroglobulins, low-density lipoproteins
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 778-786. doi:https://doi.org/10.1167/iovs.10-5759
Differential Effects of PPARγ Ligands on Oxidative Stress–Induced Death of Retinal Pigmented Epithelial Cells Free
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Gerard A. Rodrigues; Florence Maurier-Mahé; Dixie-Lee Shurland; Anne Mclaughlin; Keith Luhrs; Emeline Throo; Laurence Delalonde-Delaunay; Diego Pallares; Fabien Schweighoffer; John Donello
Tags: agonists, epithelial cells, genes, ligands, oxidative stress
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 890-903. doi:https://doi.org/10.1167/iovs.10-5715
Curcumin Protects against NMDA-Induced Toxicity: A Possible Role for NR2A Subunit Free
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Andrea Matteucci; Roberta Cammarota; Silvia Paradisi; Monica Varano; Maria Balduzzi; Lanfranco Leo; Gian C. Bellenchi; Chiara De Nuccio; Giovanna Carnovale-Scalzo; Giovanni Scorcia; Claudio Frank; Cinzia Mallozzi; Annamaria M. Di Stasi; Sergio Visentin; Fiorella Malchiodi-Albedi
Tags: curcumin, n-methylaspartate, toxic effect
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 1070-1077. doi:https://doi.org/10.1167/iovs.10-5966

Visual Psychophysics and Physiological Optics

Objective Estimation of Visual Acuity with Preferential Looking Free
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Veit Sturm; Daniel Cassel; Moshe Eizenman
Tags: preferential looking test, visual acuity, spatial frequency, photic stimulation, scanning patterns
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 708-713. doi:https://doi.org/10.1167/iovs.09-4911
Rapid Quantification of Color Vision: The Cone Contrast Test Free
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Jeff Rabin; John Gooch; Douglas Ivan
Tags: color vision, retinal cone, cardiovascular diseases, color
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 816-820. doi:https://doi.org/10.1167/iovs.10-6283
Optical Performance of the Cornea Six Years following Photorefractive Keratectomy for Myopia Free
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Sebastiano Serrao; Giuseppe Lombardo; Pietro Ducoli; Marco Lombardo
Tags: cornea, myopia, optics, astigmatism, preoperative care
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 846-857. doi:https://doi.org/10.1167/iovs.10-5905
The Effect of Two-Zone Concentric Bifocal Spectacle Lenses on Refractive Error Development and Eye Growth in Young Chicks Free
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Yue Liu; Christine Wildsoet
Tags: lens (device), lens, crystalline, refractive errors, eye
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 1078-1086. doi:https://doi.org/10.1167/iovs.10-5716
Contrast Sensitivity Mediated by Inferred Magno- and Parvocellular Pathways in Type 2 Diabetics with and without Nonproliferative Retinopathy Free
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Mirella Gualtieri; Marcio Bandeira; Russell David Hamer; Francisco Max Damico; Ana Laura Araújo Moura; Dora Fix Ventura
Tags: contrast sensitivity, diabetes mellitus, nonproliferative diabetic retinopathy
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 1151-1155. doi:https://doi.org/10.1167/iovs.09-3705
Peripheral Refraction and Refractive Error in Singapore Chinese Children Free
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Chelvin C. A. Sng; Xiao-Yu Lin; Gus Gazzard; Benjamin Chang; Mohamed Dirani; Audrey Chia; Prabakaran Selvaraj; Kit Ian; Bjorn Drobe; Tien-Yin Wong; Seang-Mei Saw
Tags: child, chinese (other dialects), chinese people, hyperopia, myopia
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 1181-1190. doi:https://doi.org/10.1167/iovs.10-5601

Clinical Trials

Evaluation of Umbilical Cord Serum Therapy in Acute Ocular Chemical Burns Free
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Namrata Sharma; Manik Goel; Thirumurthy Velpandian; Jeewan S. Titiyal; Radhika Tandon; Rasik B. Vajpayee
Tags: chemical eye burns, umbilical cord, ocular lubricants
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 1087-1092. doi:https://doi.org/10.1167/iovs.09-4170

Perspective

The Significance of Vascular and Neural Apoptosis to the Pathology of Diabetic Retinopathy Free
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Alistair J. Barber; Thomas W. Gardner; Steven F. Abcouwer
Tags: apoptosis, diabetes mellitus, diabetic retinopathy, pathology, retina
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 1156-1163. doi:https://doi.org/10.1167/iovs.10-6293

Letters to the Editor

Functional Retinal Locus Rather than Multiple PRLs? Free
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Samuel N. Markowitz; Sophia V. Reyes; Noboru Shima
Tags: macular function, patient referral, regression analysis, retina, terminology
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 1191. doi:https://doi.org/10.1167/iovs.11-7197
Author Response: Functional Retinal Locus Rather than Multiple PRLs? Free
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Michael D. Crossland; David P. Crabb; Gary S. Rubin
Investigative Ophthalmology & Visual Science February 2011, Vol.52, 1191. doi:https://doi.org/10.1167/iovs.11-7213
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