Volume 52 Issue 1 | IOVS

Tight Junction–Associated Signaling Pathways Modulate Cell Proliferation in Uveal Melanoma Free

Ashwath Jayagopal; Jin-Long Yang; Frederick R. Haselton; Min S. Chang

Tags: cell proliferation, signal pathway, signal transduction pathways, tight junctions, uveal melanoma

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 588-593. doi:https://doi.org/10.1167/iovs.10-5746

Gene Therapy Rescues Cone Structure and Function in the 3-Month-Old rd12 Mouse: A Model for Midcourse RPE65 Leber Congenital Amaurosis Free

PDF

Xia Li; Wensheng Li; Xufeng Dai; Fansheng Kong; Qinxiang Zheng; Xiangtian Zhou; Fan Lü; Bo Chang; Bärbel Rohrer; William. W. Hauswirth; Jia Qu; Ji-jing Pang

Tags: gene therapy, leber's amaurosis, mice, retinal cone, retina

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 7-15. doi:https://doi.org/10.1167/iovs.10-6138

Role of the Adrenergic System in a Mouse Model of Oxygen-Induced Retinopathy: Antiangiogenic Effects of β-Adrenoreceptor Blockade Free

PDF

Chiara Ristori; Luca Filippi; Massimo Dal Monte; Davide Martini; Maurizio Cammalleri; Pina Fortunato; Giancarlo la Marca; Patrizio Fiorini; Paola Bagnoli

Tags: angiogenesis inhibitors, hypoxia, insulin-like growth factor i, insulin-like-growth factor i receptor, mice

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 155-170. doi:https://doi.org/10.1167/iovs.10-5536

Association of Interferon-γ, Interleukin-10, and Tumor Necrosis Factor-α Gene Polymorphisms with Occurrence and Severity of Eales' Disease Free

PDF

Aditi Sen; Suman Kalyan Paine; Imran Hussain Chowdhury; Lakshmi Kanta Mondal; Amrita Mukherjee; Atanu Biswas; Subhankar Chowdhury; Sujata Bhattacharya; Basudev Bhattacharya

Tags: eales' disease, genes, genotype, human leukocyte interferon, interferons

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 171-178. doi:https://doi.org/10.1167/iovs.10-5885

Interaction of Recombinant Myocilin with the Matricellular Protein SPARC: Functional Implications Free

PDF

José-Daniel Aroca-Aguilar; Francisco Sánchez-Sánchez; Sikha Ghosh; Ana Fernández-Navarro; Miguel Coca-Prados; Julio Escribano

Tags: myoc gene, proteins, sparc study

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 179-189. doi:https://doi.org/10.1167/iovs.09-4866

Three Gene-Targeted Mouse Models of RNA Splicing Factor RP Show Late-Onset RPE and Retinal Degeneration Free

PDF

John J. Graziotto; Michael H. Farkas; Kinga Bujakowska; Bertrand M. Deramaudt; Qi Zhang; Emeline F. Nandrot; Chris F. Inglehearn; Shomi S. Bhattacharya; Eric A. Pierce

Tags: genes, mice, retinal degeneration, rna splicing

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 190-198. doi:https://doi.org/10.1167/iovs.10-5194

Expanding the Spectrum of FOXC1 and PITX2 Mutations and Copy Number Changes in Patients with Anterior Segment Malformations Free

PDF

Barbara D'haene; Françoise Meire; Ilse Claerhout; Hester Y. Kroes; Astrid Plomp; Yvonne H. Arens; Thomy de Ravel; Ingele Casteels; Sarah De Jaegere; Sally Hooghe; Wim Wuyts; Jenneke van den Ende; Françoise Roulez; Hermine E. Veenstra-Knol; Rogier A. Oldenburg; Jacques Giltay; Johanna B. G. M. Verheij; Jan-Tjeerd de Faber; Björn Menten; Anne De Paepe; Philippe Kestelyn; Bart P. Leroy; Elfride De Baere

Tags: congenital abnormality, mutation, screening

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 324-333. doi:https://doi.org/10.1167/iovs.10-5309

Identification of Disease-Causing Mutations in Autosomal Dominant Retinitis Pigmentosa (adRP) Using Next-Generation DNA Sequencing Free

PDF

Sara J. Bowne; Lori S. Sullivan; Daniel C. Koboldt; Li Ding; Robert Fulton; Rachel M. Abbott; Erica J. Sodergren; David G. Birch; Dianna H. Wheaton; John R. Heckenlively; Qin Liu; Eric A. Pierce; George M. Weinstock; Stephen P. Daiger

Tags: family, libraries, mutation, polymerase chain reaction, retinitis pigmentosa

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 494-503. doi:https://doi.org/10.1167/iovs.10-6180

Cholestenoic Acid Is an Important Elimination Product of Cholesterol in the Retina: Comparison of Retinal Cholesterol Metabolism with That in the Brain Free

PDF

Natalia Mast; Rachel Reem; Ilya Bederman; Suber Huang; Pier Luigi DiPatre; Ingemar Bjorkhem; Irina A. Pikuleva

Tags: brain, cholesterol, retina, cholesterol metabolism, excretory function

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 594-603. doi:https://doi.org/10.1167/iovs.10-6021

Clinical and Epidemiologic Research

Outcomes of Cataract Surgery in Urban Southern China: The Liwan Eye Study Free

PDF

Wenyong Huang; Guofu Huang; Dandan Wang; Qiuxia Yin; Paul J. Foster; Mingguang He

Tags: cataract surgery, china, eye, surgical procedures, operative

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 16-20. doi:https://doi.org/10.1167/iovs.10-5382

Relative Peripheral Refractive Error and the Risk of Onset and Progression of Myopia in Children Free

PDF

Donald O. Mutti; Loraine T. Sinnott; G. Lynn Mitchell; Lisa A. Jones-Jordan; Melvin L. Moeschberger; Susan A. Cotter; Robert N. Kleinstein; Ruth E. Manny; J. Daniel Twelker; Karla Zadnik; for the CLEERE Study Group

Tags: child, myopia, refractive errors

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 199-205. doi:https://doi.org/10.1167/iovs.09-4826

Anophthalmos, Microphthalmos, and Typical Coloboma in the United Kingdom: A Prospective Study of Incidence and Risk Free

PDF

Shaheen P. Shah; Amy E. Taylor; Jane C. Sowden; Nicola K. Ragge; Isabelle Russell-Eggitt; Jugnoo S. Rahi; Clare E. Gilbert; for the Surveillance of Eye Anomalies (SEA-UK) Special Interest Group

Tags: anophthalmos, child, coloboma, incidence, microphthalmos

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 558-564. doi:https://doi.org/10.1167/iovs.10-5263

Cornea

Comparison of Candidate Materials for a Synthetic Osteo-Odonto Keratoprosthesis Device Free

PDF

Xiao Wei Tan; A. Promoda P. Perera; Anna Tan; Donald Tan; K. A. Khor; Roger W. Beuerman; Jodhbir S. Mehta

Tags: anti-bacterial agents, cell adhesion, cornea, keratocytes, proteins

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 21-29. doi:https://doi.org/10.1167/iovs.10-6186

Innervation of the Mouse Cornea during Development Free

PDF

Chelsey C. McKenna; Peter Y. Lwigale

Tags: cornea, mice, nerve supply, neurons, epithelium

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 30-35. doi:https://doi.org/10.1167/iovs.10-5902

3-D Characterization of the Corneal Shape in Fuchs Dystrophy and Pseudophakic Keratopathy Free

PDF

Isabelle Brunette; Denis Sherknies; Mark A. Terry; Miguel Chagnon; Jean-Louis Bourges; Jean Meunier

Tags: cornea, maps

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 206-214. doi:https://doi.org/10.1167/iovs.09-4101

Generation of Bioengineered Corneas with Decellularized Xenografts and Human Keratocytes Free

PDF

Miguel Gonzalez-Andrades; Juan de la Cruz Cardona; Ana Maria Ionescu; Antonio Campos; Maria del Mar Perez; Miguel Alaminos

Tags: cornea, keratocytes, sodium chloride, transplantation, heterologous, atrial premature complexes

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 215-222. doi:https://doi.org/10.1167/iovs.09-4773

Effects of Photodynamic Therapy on Rapidly Growing Nontuberculous Mycobacteria Keratitis Free

PDF

Min-Hsiu Shih; Fu-Chin Huang

Tags: amikacin, antibiotics, keratitis, nontuberculous mycobacteria, photochemotherapy

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 223-229. doi:https://doi.org/10.1167/iovs.10-5593

The Nuclear-Factor κB Pathway Is Activated in Pterygium Free

PDF

Jay Jyh Kuen Siak; See Liang Ng; Li-Fong Seet; Roger W. Beuerman; Louis Tong

Tags: pterygium, tumor necrosis factors

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 230-236. doi:https://doi.org/10.1167/iovs.10-5735

Spontaneous Lymphatic Vessel Formation and Regression in the Murine Cornea Free

PDF

Hui Zhang; Xuemei Hu; Julie Tse; Firehiwott Tilahun; Mengsheng Qiu; Lu Chen

Tags: cornea, lymphatic vessels

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 334-338. doi:https://doi.org/10.1167/iovs.10-5404

Clinical and Antiviral Efficacy of an Ophthalmic Formulation of Dexamethasone Povidone-Iodine in a Rabbit Model of Adenoviral Keratoconjunctivitis Free

PDF

Christian Clement; Joseph A. Capriotti; Manish Kumar; Jeffery A. Hobden; Timothy P. Foster; Partha S. Bhattacharjee; Hilary W. Thompson; Rashed Mahmud; Bo Liang; James M. Hill

Tags: adenoviruses, antiviral agents, cidofovir, dexamethasone, eye

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 339-344. doi:https://doi.org/10.1167/iovs.10-5944

PI 3-Kinase/Rac1 and ERK1/2 Regulate FGF-2–Mediated Cell Proliferation through Phosphorylation of p27 at Ser10 by KIS and at Thr187 by Cdc25A/Cdk2 Free

PDF

Jeong Goo Lee; EunDuck P. Kay

Tags: 1-phosphatidylinositol 3-kinase, cdk2 protein, human, cell proliferation, fibroblast growth factor 2, phosphorylation

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 417-426. doi:https://doi.org/10.1167/iovs.10-6140

Hydrogen and N-Acetyl-l-Cysteine Rescue Oxidative Stress-Induced Angiogenesis in a Mouse CornealAlkali-Burn Model Free

PDF

Miyuki Kubota; Shigeto Shimmura; Shunsuke Kubota; Hideyuki Miyashita; Naoko Kato; Kousuke Noda; Yoko Ozawa; Tomohiko Usui; Susumu Ishida; Kazuo Umezawa; Toshihide Kurihara; Kazuo Tsubota

Tags: alkalies, burns, choroidal neovascularization, copy number polymorphism, cysteine

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 427-433. doi:https://doi.org/10.1167/iovs.10-6167

Noninvasive Assessment of Tear Stability with the Tear Stability Analysis System in Tear Dysfunction Patients Free

PDF

Koray Gumus; Charlene Hong Crockett; Kavita Rao; Elizabeth Yeu; Mitchell P. Weikert; Mariko Shirayama; Shigeki Hada; Stephen C. Pflugfelder

Tags: pathophysiology, cornea, tear film finding

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 456-461. doi:https://doi.org/10.1167/iovs.10-5292

In Vivo Evaluation of Ocular Demodicosis Using Laser Scanning Confocal Microscopy Free

PDF

Takashi Kojima; Reiko Ishida; Enrique Adan Sato; Tetsuya Kawakita; Osama M. A. Ibrahim; Yukihiro Matsumoto; Minako Kaido; Murat Dogru; Kazuo Tsubota

Tags: demodex infestations, microscopy, confocal scanning laser

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 565-569. doi:https://doi.org/10.1167/iovs.10-5477

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Imaging Reveals Optic Tract Degeneration in Hemianopia Free

PDF

Holly Bridge; Panitha Jindahra; John Barbur; Gordon T. Plant

Tags: diagnostic imaging, hemianopsia, optic tract, tissue degeneration, volume

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 382-388. doi:https://doi.org/10.1167/iovs.10-5708

Optokinetic Nystagmus Suppression as an Index of the Allocation of Visual Attention Free

PDF

Nikki J. Rubinstein; Larry A. Abel

Tags: attention, nystagmus, optokinetic, visual attention

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 462-467. doi:https://doi.org/10.1167/iovs.10-6016

Glaucoma

Optic Neuropathy Due to Microbead-Induced Elevated Intraocular Pressure in the Mouse Free

PDF

Huihui Chen; Xin Wei; Kin-Sang Cho; Guochun Chen; Rebecca Sappington; David J. Calkins; Dong F. Chen

Tags: intraocular pressure, mice, microspheres, optic nerve disorders, raised intraocular pressure

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 36-44. doi:https://doi.org/10.1167/iovs.09-5115

The Elastin Fiber System between and Adjacent to Collector Channels in the Human Juxtacanalicular Tissue Free

PDF

Cheryl R. Hann; Michael P. Fautsch

Tags: body tissue, elastin

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 45-50. doi:https://doi.org/10.1167/iovs.10-5620

Microarray Analysis of Iris Gene Expression in Mice with Mutations Influencing Pigmentation Free

PDF

Colleen M. Trantow; Tryphena L. Cuffy; John H. Fingert; Markus H. Kuehn; Michael G. Anderson

Tags: gene expression, iris, mice, mutation, pigment

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 237-248. doi:https://doi.org/10.1167/iovs.10-5479

Deformation of the Early Glaucomatous Monkey Optic Nerve Head Connective Tissue after Acute IOP Elevation in 3-D Histomorphometric Reconstructions Free

PDF

Hongli Yang; Hilary Thompson; Michael D. Roberts; Ian A. Sigal; J. Crawford Downs; Claude F. Burgoyne

Tags: cercopithecidae, connective tissue, electroencephalography, eye, glaucoma

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 345-363. doi:https://doi.org/10.1167/iovs.09-5122

Retinal Ganglion Cell Loss in a Rat Ocular Hypertension Model Is Sectorial and Involves Early Optic Nerve Axon Loss Free

PDF

Ileana Soto; Mary E. Pease; Janice L. Son; Xiaohai Shi; Harry A. Quigley; Nicholas Marsh-Armstrong

Tags: axon, ocular hypertension, optic nerve, retina, retinal ganglion cells

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 434-441. doi:https://doi.org/10.1167/iovs.10-5856

Cytokine-Dependent ELAM-1 Induction and Concomitant Intraocular Pressure Regulation in Porcine Anterior Eye Perfusion Culture Free

PDF

Marco T. Birke; Kerstin Birke; Elke Lütjen-Drecoll; Ursula Schlötzer-Schrehardt; Christian M. Hammer

Tags: e-selectin, eye, intraocular pressure, perfusion, suidae

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 468-475. doi:https://doi.org/10.1167/iovs.10-5990

Cell Proliferation and Interleukin-6–Type Cytokine Signaling Are Implicated by Gene Expression Responses in Early Optic Nerve Head Injury in Rat Glaucoma Free

PDF

Elaine C. Johnson; Thomas A. Doser; William O. Cepurna; Jennifer A. Dyck; Lijun Jia; Ying Guo; Wendi S. Lambert; John C. Morrison

Tags: optic disk, wounds and injuries, glaucoma, cytokine, genes

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 504-518. doi:https://doi.org/10.1167/iovs.10-5317

A Comparison of Functional and Structural Measures for Identifying Progression of Glaucoma Free

PDF

Daiyan Xin; Vivienne C. Greenstein; Robert Ritch; Jeffrey M. Liebmann; Carlos Gustavo De Moraes; Donald C. Hood

Tags: eye, glaucoma

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 519-526. doi:https://doi.org/10.1167/iovs.10-5174

High-Resolution Multifocal Pupillographic Objective Perimetry in Glaucoma Free

PDF

Corinne F. Carle; Andrew C. James; Maria Kolic; Yik-Wen Loh; Ted Maddess

Tags: glaucoma, perimetry, eye

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 604-610. doi:https://doi.org/10.1167/iovs.10-5737

Immunology and Microbiology

Biocidal Efficacy of Silver-Impregnated Contact Lens Storage Cases In Vitro Free

PDF

Jaya Dantam; Hua Zhu; Fiona Stapleton

Tags: contact lens storage case, silver

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 51-57. doi:https://doi.org/10.1167/iovs.09-4809

An Antiviral Small-Interfering RNA Simultaneously Effective against the Most Prevalent Enteroviruses Causing Acute Hemorrhagic Conjunctivitis Free

PDF

Eun Jung Jun; Min Ah Won; Jeonghyun Ahn; Ara Ko; Haein Moon; Hungwon Tchah; Yoo Kyum Kim; Heuiran Lee

Tags: antiviral agents, conjunctivitis, acute hemorrhagic, enterovirus, rna, rna, small interfering

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 58-63. doi:https://doi.org/10.1167/iovs.09-5051

Cataract Surgery Induces Retinal Pro-inflammatory Gene Expression and Protein Secretion Free

PDF

Heping Xu; Mei Chen; John V. Forrester; Noemi Lois

Tags: cataract surgery, choroid, eye, gene expression, lens (device)

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 249-255. doi:https://doi.org/10.1167/iovs.10-6001

Spontaneous Bacterial Keratitis in CD36 Knockout Mice Free

PDF

Julia Klocke; Rita N. Barcia; Susan Heimer; Elke Cario; James Zieske; Michael S. Gilmore; Bruce R. Ksander; Meredith S. Gregory

Tags: bacterial keratitis, cd36 antigens, cornea, mice

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 256-263. doi:https://doi.org/10.1167/iovs.10-5566

Altered Ganglioside Expression Modulates the Pathogenic Mechanism of Thyroid-Associated Ophthalmopathy by Increase in Hyaluronic Acid Free

PDF

Koung Hoon Kook; Youn-Hee Choi; Yu Rim Kim; Soo Jung Park; Ilo Jou; Sung Joo Kim; Sang Yeul Lee

Tags: fibroblasts, gangliosides, graves' ophthalmopathy, hyaluronic acid, body tissue

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 264-273. doi:https://doi.org/10.1167/iovs.10-5276

CXCL10 Is Required to Maintain T-Cell Populations and to Control Parasite Replication during Chronic Ocular Toxoplasmosis Free

PDF

Kazumi Norose; Akitoshi Kikumura; Andrew D. Luster; Christopher A. Hunter; Tajie H. Harris

Tags: eye, ocular toxoplasmosis, parasites, t-lymphocytes, retina

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 389-398. doi:https://doi.org/10.1167/iovs.10-5819

Induction of Regulatory T Cells by Infliximab in Behçet's Disease Free

PDF

Sunao Sugita; Yukiko Yamada; Satoshi Kaneko; Shintaro Horie; Manabu Mochizuki

Tags: behcet syndrome, foxp3 gene, infliximab, regulatory t-lymphocytes, t-lymphocytes

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 476-484. doi:https://doi.org/10.1167/iovs.10-5916

Dynamic Changes of microRNAs in the Eye during the Development of Experimental Autoimmune Uveoretinitis Free

PDF

Waka Ishida; Ken Fukuda; Takuma Higuchi; Mina Kajisako; Shuji Sakamoto; Atsuki Fukushima

Tags: eye, micrornas, autoimmune diseases, mice, cytokine

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 611-617. doi:https://doi.org/10.1167/iovs.10-6115

Physiology and Pharmacology

Effects of Fasudil, a Rho-Associated Protein Kinase Inhibitor, on Optic Nerve Head Blood Flow in Rabbits Free

PDF

Tetsuya Sugiyama; Maho Shibata; Sumiko Kajiura; Takashi Okuno; Masahiro Tonari; Hidehiro Oku; Tsunehiko Ikeda

Tags: optic disk, oryctolagus cuniculus, protein kinase inhibitor, vascular flow

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 64-69. doi:https://doi.org/10.1167/iovs.10-5265

TRPV1 Activation Is Required for Hypertonicity-Stimulated Inflammatory Cytokine Release in Human Corneal Epithelial Cells Free

PDF

Zan Pan; Zheng Wang; Hua Yang; Fan Zhang; Peter S. Reinach

Tags: epidermal growth factor receptors, hypertonicity, trpv1 receptor, cytokine, corneal epithelial cells

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 485-493. doi:https://doi.org/10.1167/iovs.10-5801

Retina

Human Retinal Disease from AIPL1 Gene Mutations: Foveal Cone Loss with Minimal Macular Photoreceptors and Rod Function Remaining Free

PDF

Samuel G. Jacobson; Artur V. Cideciyan; Tomas S. Aleman; Alexander Sumaroka; Alejandro J. Roman; Malgorzata Swider; Sharon B. Schwartz; Eyal Banin; Edwin M. Stone

Tags: diagnostic imaging, mutation, photoreceptors, retinal cone, retinal degeneration

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 70-79. doi:https://doi.org/10.1167/iovs.10-6127

Pharmacokinetics and Pharmacodynamics of a Sustained-Release Dexamethasone Intravitreal Implant Free

PDF

Joan-En Chang-Lin; Mayssa Attar; Andrew A. Acheampong; Michael R. Robinson; Scott M. Whitcup; Baruch D. Kuppermann; Devin Welty

Tags: dexamethasone, implants, intravitreal implants, pharmacodynamics, pharmacokinetics

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 80-86. doi:https://doi.org/10.1167/iovs.10-5285

In Vivo Measurement of Blood Velocity in Human Major Retinal Vessels Using the Laser Speckle Method Free

PDF

Miyuki Nagahara; Yasuhiro Tamaki; Atsuo Tomidokoro; Makoto Araie

Tags: lasers, retinal vessels, velocity, fluid flow, diameter

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 87-92. doi:https://doi.org/10.1167/iovs.09-4422

Different Populations of Circulating Endothelial Cells in Patients with Age-Related Macular Degeneration: A Novel Insight into Pathogenesis Free

PDF

Anna Machalińska; Krzysztof Safranow; Violetta Dziedziejko; Katarzyna Mozolewska-Piotrowska; Edyta Paczkowska; Patrycja Kłos; Ewa Pius; Katarzyna Grymuła; Barbara Wiszniewska; Danuta Karczewicz; Bogusław Machaliński

Tags: age-related macular degeneration, chronic exertional compartment syndrome, cytokine, electroconvulsive therapy, endothelial cells

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 93-100. doi:https://doi.org/10.1167/iovs.10-5756

The Transition Zone between Healthy and Diseased Retina in Patients with Retinitis Pigmentosa Free

PDF

Donald C. Hood; Margot A. Lazow; Kirsten G. Locke; Vivienne C. Greenstein; David G. Birch

Tags: retina, retinitis pigmentosa

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 101-108. doi:https://doi.org/10.1167/iovs.10-5799

Age-Dependent Retinal Iron Accumulation and Degeneration in Hepcidin Knockout Mice Free

PDF

Majda Hadziahmetovic; Ying Song; Padmavathi Ponnuru; Jared Iacovelli; Allan Hunter; Nadine Haddad; John Beard; James R. Connor; Sophie Vaulont; Joshua L. Dunaief

Tags: iron, mice, retina, hepcidin, tissue degeneration

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 109-118. doi:https://doi.org/10.1167/iovs.10-6113

Submacular DL-α-Aminoadipic Acid Eradicates Primate Photoreceptors but Does Not Affect Luteal Pigment or the Retinal Vasculature Free

PDF

Weiyong Shen; Jun Zhang; Sook Hyun Chung; Yuntao Hu; Zhizhong Ma; Mark C. Gillies

Tags: cercopithecidae, photoreceptors, pigment, primates, retinal vasculature

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 119-127. doi:https://doi.org/10.1167/iovs.10-6033

Correlations between M-CHARTS and PHP Findings and Subjective Perception of Metamorphopsia in Patients with Macular Diseases Free

PDF

Eiko Arimura; Chota Matsumoto; Hiroki Nomoto; Shigeki Hashimoto; Sonoko Takada; Sachiko Okuyama; Yoshikazu Shimomura

Tags: metamorphopsias, questionnaires, tables and charts, macular disorders, perception

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 128-135. doi:https://doi.org/10.1167/iovs.09-3535

Retinal Venous Oxygen Saturation Increases by Flicker Light Stimulation Free

PDF

Martin Hammer; Walthard Vilser; Thomas Riemer; Fanny Liemt; Susanne Jentsch; Jens Dawczynski; Dietrich Schweitzer

Tags: photopsia, venous oxygen saturation

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 274-277. doi:https://doi.org/10.1167/iovs.10-5537

Intravitreal Injection of Exendin-4 Analogue Protects Retinal Cells in Early Diabetic Rats Free

PDF

Yu Zhang; Jingfa Zhang; Qingping Wang; Xia Lei; Qing Chu; Guo-Tong Xu; Wen Ye

Tags: diabetes mellitus, exenatide, intravitreal injections, rats, retina

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 278-285. doi:https://doi.org/10.1167/iovs.09-4727

Magnetic Resonance Imaging of Vascular Oxygenation Changes during Hyperoxia and Carbogen Challenges in the Human Retina Free

PDF

Yi Zhang; Qi Peng; Jeffrey W. Kiel; Carlos A. Rosende; Timothy Q. Duong

Tags: alveolar ventilation function, blood oxygen level dependent, cell respiration, functional magnetic resonance imaging, hyperoxia

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 286-291. doi:https://doi.org/10.1167/iovs.10-6108

The Phenotype of Severe Early Childhood Onset Retinal Dystrophy (SECORD) from Mutation of RPE65 and Differentiation from Leber Congenital Amaurosis Free

PDF

Richard G. Weleber; Michel Michaelides; Karmen M. Trzupek; Niamh B. Stover; Edwin M. Stone

Tags: child, electroretinography, eye, leber's amaurosis, mutation

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 292-302. doi:https://doi.org/10.1167/iovs.10-6106

Cone Degeneration Following Rod Ablation in a Reversible Model of Retinal Degeneration Free

PDF

Rene Y. Choi; Gustav A. Engbretson; Eduardo C. Solessio; Georgette A. Jones; Adam Coughlin; Ilija Aleksic; Michael E. Zuber

Tags: ablation, retinal cone, retinal degeneration, rod photoreceptors, tissue degeneration

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 364-373. doi:https://doi.org/10.1167/iovs.10-5347

Diabetic Macular Edema: Fundus Autofluorescence and Functional Correlations Free

PDF

Stela Vujosevic; Margherita Casciano; Elisabetta Pilotto; Barbara Boccassini; Monica Varano; Edoardo Midena

Tags: diabetic macular edema, edema, fundus autofluorescence imaging, eye, visual acuity

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 442-448. doi:https://doi.org/10.1167/iovs.10-5588

Stimulation with a Wireless Intraocular Epiretinal Implant Elicits Visual Percepts in Blind Humans Free

PDF

Susanne Klauke; Michael Goertz; Stefan Rein; Dirk Hoehl; Uwe Thomas; Reinhard Eckhorn; Frank Bremmer; Thomas Wachtler

Tags: implants, wireless technology

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 449-455. doi:https://doi.org/10.1167/iovs.09-4410

Race- and Sex-Related Differences in Retinal Thickness and Foveal Pit Morphology Free

PDF

Melissa Wagner-Schuman; Adam M. Dubis; Rick N. Nordgren; Yuming Lei; Daniel Odell; Hellen Chiao; Eric Weh; William Fischer; Yusufu Sulai; Alfredo Dubra; Joseph Carroll

Tags: continental population groups, language morphology, morphology

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 625-634. doi:https://doi.org/10.1167/iovs.10-5886

Retinal Cell Biology

SOX2 Is Required for Adult Human Müller Stem Cell Survival and Maintenance of Progenicity In Vitro Free

PDF

Bhairavi Bhatia; Shweta Singhal; Daniel N. Tadman; Peng T. Khaw; G. Astrid Limb

Tags: adult, stem cells, transfection, down-regulation, proteins

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 136-145. doi:https://doi.org/10.1167/iovs.10-5208

Isolation and Characterization of Vitreous Insulin-like Growth Factor Binding Proteins Free

PDF

Clyde Guidry; Jeffery L. King

Tags: insulin-like growth factor binding protein 3, insulin-like growth-factor-binding proteins, ligands, vitreous body, patient isolation

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 303-309. doi:https://doi.org/10.1167/iovs.10-5920

Role of CD44⁺ Stem Cells in Mural Cell Formation in the Human Choroid: Evidence of Vascular Instability Due to Limited Pericyte Ensheathment Free

PDF

Tailoi Chan-Ling; Mark E. Koina; Janet R. McColm; Jane E. Dahlstrom; Elaine Bean; Sam Adamson; Steven Yun; Louise Baxter

Tags: cd44 antigens, choroid, homing-associated cell adhesion molecule, pericytes, adult

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 399-410. doi:https://doi.org/10.1167/iovs.10-5403

Sigma Receptor 1 Modulates Endoplasmic Reticulum Stress in Retinal Neurons Free

PDF

Yonju Ha; Ying Dun; Muthusamy Thangaraju; Jennifer Duplantier; Zheng Dong; Kebin Liu; Vadivel Ganapathy; Sylvia B. Smith

Tags: genes, neurons, proteins, stress, receptors, sigma

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 527-540. doi:https://doi.org/10.1167/iovs.10-5731

The Role of RPE Cell-Associated VEGF₁₈₉ in Choroidal Endothelial Cell Transmigration across the RPE Free

PDF

Haibo Wang; Pete Geisen; Erika S. Wittchen; Bradley King; Keith Burridge; Patricia A. D'Amore; M. Elizabeth Hartnett

Tags: vascular endothelial growth factor a, chronic exertional compartment syndrome, endothelial cells

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 570-578. doi:https://doi.org/10.1167/iovs.10-5595

RhoA Inactivation Prevents Photoreceptor Axon Retraction in an In Vitro Model of Acute Retinal Detachment Free

PDF

Aurora Maria Fontainhas; Ellen Townes-Anderson

Tags: axon, photoreceptors, retinal detachment, rhoa gtp-binding protein, retina

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 579-587. doi:https://doi.org/10.1167/iovs.10-5744

Visual Neuroscience

Spatiotemporal Properties of Multipeaked Electrically Evoked Potentials Elicited by Penetrative Optic Nerve Stimulation in Rabbits Free

PDF

Jingjing Sun; Yiliang Lu; Pengjia Cao; Xiaoliang Li; Changsi Cai; Xinyu Chai; Qiushi Ren; Liming Li

Tags: evoked potentials, optic nerve, oryctolagus cuniculus, electric stimulation, visual prosthesis

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 146-154. doi:https://doi.org/10.1167/iovs.09-4024

Different Inner Retinal Pathways Mediate Rod-Cone Input in Irradiance Detection for the Pupillary Light Reflex and Regulation of Behavioral State in Mice Free

PDF

Stewart Thompson; Steven F. Stasheff; Jasmine Hernandez; Erik Nylen; Jade S. East; Randy H. Kardon; Lawrence H. Pinto; Robert F. Mullins; Edwin M. Stone

Tags: mice, pupil light reflex, retinal cone, rod photoreceptors, regulation

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 618-623. doi:https://doi.org/10.1167/iovs.10-6146

Visual Psychophysics and Physiological Optics

Static and Dynamic Measurements of Accommodation in Individuals with Down Syndrome Free

PDF

Heather A. Anderson; Ruth E. Manny; Adrian Glasser; Karla K. Stuebing

Tags: down syndrome, visual accommodation, lens (device), lens, crystalline

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 310-317. doi:https://doi.org/10.1167/iovs.10-5301

Influence of Optical Defocus on Peripheral Vision Free

PDF

Robert Rosén; Linda Lundström; Peter Unsbo

Tags: optics, peripheral vision, lens (device), lens, crystalline

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 318-323. doi:https://doi.org/10.1167/iovs.10-5623

Task-Specific Fixation Behavior in Macular Disease Free

PDF

Michael D. Crossland; David P. Crabb; Gary S. Rubin

Tags: age-related macular degeneration, macular disorders

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 411-416. doi:https://doi.org/10.1167/iovs.10-5473

Awareness and Filling-in of the Human Blind Spot: Linking Psychophysics with Retinal Topography Free

PDF

Richard V. Abadi; Glen Jeffery; Jonathan S. Murphy

Tags: psychophysics, retinal blind spot

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 541-548. doi:https://doi.org/10.1167/iovs.10-5910

Clinical Trials

Optical Coherence Tomography and Autofluorescence Findings in Areas with Geographic Atrophy Due to Age-Related Macular Degeneration Free

PDF

Steffen Schmitz-Valckenberg; Monika Fleckenstein; Arno P. Göbel; Thomas C. Hohman; Frank G. Holz

Tags: age-related macular degeneration, atrophy, autofluorescence, optical coherence tomography, atrophic condition of skin

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 1-6. doi:https://doi.org/10.1167/iovs.10-5619

Evaluation of the Flexibility, Efficacy, and Safety of a Foldable Capsular Vitreous Body in the Treatment of Severe Retinal Detachment Free

PDF

Xiaofeng Lin; Jian Ge; Qianying Gao; Zhenfang Wang; Chongde Long; Liwen He; Yaqin Liu; Zhaoxin Jiang

Tags: eye, implantation procedure, retinal detachment, safety, vitreous body

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 374-381. doi:https://doi.org/10.1167/iovs.10-5869

Temporal Interactions during Paired-Electrode Stimulation in Two Retinal Prosthesis Subjects Free

PDF

Alan Horsager; Geoffrey M. Boynton; Robert J. Greenberg; Ione Fine

Tags: visual prosthesis

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 549-557. doi:https://doi.org/10.1167/iovs.10-5282

Letters to the Editor

Can Vascular Function Be Assessed by the Interpretation of Retinal Vascular Diameter Changes? Free

PDF

Konstantin E. Kotliar; Ines M. Lanzl

Tags: diameter, photopsia

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 635-636. doi:https://doi.org/10.1167/iovs.10-6202

Author Response: Can Vascular Function Be Assessed by the Interpretation of Retinal Vascular Diameter Changes? Free

PDF

Rebekka Heitmar; Andrew Blann; Robert Peter Cubbidge; Gregory Lip; Doina Gherghel

Tags: diameter, photopsia

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 636-638. doi:https://doi.org/10.1167/iovs.10-6690

On the Presence of (O-acyl)-omega-hydroxy Fatty Acids and of Their Esters in Human Meibomian Gland Secretions Free

PDF

Igor A. Butovich

Tags: bodily secretions, esters, fatty acids, meibomian gland, lipids

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 639-641. doi:https://doi.org/10.1167/iovs.10-7028

Erratum

Erratum Free

PDF

Investigative Ophthalmology & Visual Science January 2011, Vol.52, 624. doi:https://doi.org/10.1167/iovs.09-4266a

This feature is available to authenticated users only.

To View More...

You must be signed into an individual account to use this feature.