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Anatomy and Pathology/Oncology

The Effect of Pirenzepine on Positive- and Negative-Lens–Induced Refractive Error and Ocular Growth in Chicks Free
PDF
Sangeetha Metlapally; Neville A. McBrien
Tags: eye, lens (device), lens, crystalline, pirenzepine, refractive errors
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5438-5444. doi:https://doi.org/10.1167/iovs.09-4431
Inflammatory Cytokines in Eyes with Uveal Melanoma and Relation with Macrophage Infiltration Free
PDF
Long V. Ly; Inge H. G. Bronkhorst; Els van Beelen; Johannes Vrolijk; Andrew W. Taylor; Mieke Versluis; Gregorius P. M. Luyten; Martine J. Jager
Tags: cytokine, eye, macrophages, uveal melanoma
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5445-5451. doi:https://doi.org/10.1167/iovs.10-5526

Biochemistry and Molecular Biology

Diadenosine Polyphosphates in Tears of Sjögren Syndrome Patients Free
PDF
Gonzalo Carracedo; Assumpta Peral; Jesús Pintor
Tags: polyphosphates, sjogren's syndrome, dry eye syndromes
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5452-5459. doi:https://doi.org/10.1167/iovs.09-5088
Association of PDGF-BB–Induced Thrombomodulin with the Regulation of Inflammation in the Corneal and Scleral Stroma Free
PDF
Hiroyuki Namba; Yoshiko Kashiwagi; Koichi Nishitsuka; Hiroshi Takamura; Teiko Yamamoto; Hidetoshi Yamashita
Tags: cornea, inflammation, platelet-derived growth factor, sclera, stromal cells
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5460-5469. doi:https://doi.org/10.1167/iovs.10-5578
Mitochondrial DNA Damage as a Potential Mechanism for Age-Related Macular Degeneration Free
PDF
Pabalu P. Karunadharma; Curtis L. Nordgaard; Timothy W. Olsen; Deborah A. Ferrington
Tags: dna, mitochondrial, age-related macular degeneration, aging, dna, polymerase chain reaction
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5470-5479. doi:https://doi.org/10.1167/iovs.10-5429
Identification of Large Rearrangements of the PCDH15 Gene by Combined MLPA and a CGH: Large Duplications Are Responsible for Usher Syndrome Free
PDF
Elena Aller; Teresa Jaijo; Gema García-García; M. José Aparisi; David Blesa; Manuel Díaz-Llopis; Carmen Ayuso; José M. Millán
Tags: array-based comparative genomic hybridization, genes, polymerase chain reaction, usher syndrome, dna
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5480-5485. doi:https://doi.org/10.1167/iovs.10-5359
Increase of 8-Hydroxy-2′-Deoxyguanosine in Aqueous Humor of Patients with Exudative Age-Related Macular Degeneration Free
PDF
Ling-Ing Lau; Catherine Jui-ling Liu; Yau-Huei Wei
Tags: aqueous humor, deoxyguanosine, exudative age-related macular degeneration, choroidal neovascularization
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5486-5490. doi:https://doi.org/10.1167/iovs.10-5663
Light Activation of the Phosphoinositide Cycle in Intrinsically Photosensitive Chicken Retinal Ganglion Cells Free
PDF
Maria Ana Contín; Daniela M. Verra; Gabriela Salvador; Monica Ilincheta; Norma M. Giusto; Mario E. Guido
Tags: chickens, phosphatidylinositols, retinal ganglion cells
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5491-5498. doi:https://doi.org/10.1167/iovs.10-5643
Identification of a Promoter for the Human C1q-Tumor Necrosis Factor–Related Protein-5 Gene Associated with Late-Onset Retinal Degeneration Free
PDF
Venkata R. M. Chavali; Jeffrey R. Sommer; Robert M. Petters; Radha Ayyagari
Tags: genes, necrosis, neoplasms, proteins, retinal degeneration
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5499-5507. doi:https://doi.org/10.1167/iovs.10-5543
Meibomian Lipid Films and the Impact of Temperature Free
PDF
Igor A. Butovich; Juan C. Arciniega; Jadwiga C. Wojtowicz
Tags: body temperature, lipids, temperature
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5508-5518. doi:https://doi.org/10.1167/iovs.10-5419

Clinical and Epidemiologic Research

Influence of Diabetes and Diabetic Retinopathy on the Performance of Heidelberg Retina Tomography II for Diagnosis of Glaucoma Free
PDF
Yingfeng Zheng; Tien Y. Wong; Carol Yim-Lui Cheung; Ecosse Lamoureux; Paul Mitchell; Mingguang He; Tin Aung
Tags: diabetes mellitus, diabetic retinopathy, glaucoma, tomography, retina
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5519-5524. doi:https://doi.org/10.1167/iovs.09-5060
Effect of Image Quality, Color, and Format on the Measurement of Retinal Vascular Fractal Dimension Free
PDF
Alan Wainwright; Gerald Liew; George Burlutsky; Elena Rochtchina; Yong Ping Zhang; Wynne Hsu; Janice MongLi Lee; Tien Yin Wong; Paul Mitchell; Jie Jin Wang
Tags: color, fractals, image quality
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5525-5529. doi:https://doi.org/10.1167/iovs.09-4129
Contribution of anti-Hsp70.1 IgG Antibody Levels to the Diagnostic Certainty of Clinically Suspected Ocular Toxoplasmosis Free
PDF
Bernabé F. F. Chumpitazi; Laurence Bouillet; Hélène Fricker-Hidalgo; Tiffany Lacharme; Jean-Paul Romanet; Christian Massot; Christophe Chiquet; Hervé Pelloux
Tags: antibodies, heat-shock proteins 70, igg antibody, ocular toxoplasmosis, immunoglobulin g
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5530-5536. doi:https://doi.org/10.1167/iovs.10-5244
The Development of an Instrument to Measure Quality of Vision: The Quality of Vision (QoV) Questionnaire Free
PDF
Colm McAlinden; Konrad Pesudovs; Jonathan E. Moore
Tags: questionnaires, vision, signs and symptoms, weight measurement scales
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5537-5545. doi:https://doi.org/10.1167/iovs.10-5341

Cornea

Topographic and Tomographic Properties of Forme Fruste Keratoconus Corneas Free
PDF
Alain Saad; Damien Gatinel
Tags: cornea, keratoconus
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5546-5555. doi:https://doi.org/10.1167/iovs.10-5369
Poly(I:C)-Induced Adhesion Molecule Expression Mediated by NF-κB and Phosphoinositide 3-Kinase–Akt Signaling Pathways in Human Corneal Fibroblasts Free
PDF
Tomoko Orita; Kazuhiro Kimura; Hong-Yan Zhou; Teruo Nishida
Tags: cell adhesion molecules, cornea, fibroblasts, intercellular adhesion molecule 1, phosphoinositide 3-kinase
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5556-5560. doi:https://doi.org/10.1167/iovs.09-4909
Twist2: Role in Corneal Stromal Keratocyte Proliferation and Corneal Thickness Free
PDF
Linda Weaving; Marija Mihelec; Rebecca Storen; Drazen Sosic; John R. Grigg; Patrick P. L. Tam; Robyn V. Jamieson
Tags: cornea, keratocytes, mice, adult
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5561-5570. doi:https://doi.org/10.1167/iovs.09-5123
Upper Punctal Occlusion versus Lower Punctal Occlusion in Dry Eye Free
PDF
Feng Chen; Jianhua Wang; Wei Chen; Meixiao Shen; Suzhong Xu; Fan Lu
Tags: dry eye syndromes, signs and symptoms, eye
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5571-5577. doi:https://doi.org/10.1167/iovs.09-5097
Decorin Accumulation Contributes to the Stromal Opacities Found in Congenital Stromal Corneal Dystrophy Free
PDF
Cecilie Bredrup; Espen Stang; Ove Bruland; Barbara P. Palka; Robert D. Young; Jan Haavik; Per M. Knappskog; Eyvind Rødahl
Tags: cornea, gel chromatography, keratocytes, stromal dystrophies, corneal, microscopy, immunoelectron
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5578-5582. doi:https://doi.org/10.1167/iovs.09-4933
Modeling the Intracorneal Ring Segment Effect in Keratoconus Using Refractive, Keratometric, and Corneal Aberrometric Data Free
PDF
David P. Piñero; Jorge L. Alio; Miguel A. Teus; Rafael I. Barraquer; Antonio Uceda-Montañés
Tags: cornea, keratoconus, preoperative care, surgical procedures, operative
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5583-5591. doi:https://doi.org/10.1167/iovs.09-5017
Altered Morphology and Function of the Lacrimal Functional Unit in Protein Kinase Cα Knockout Mice Free
PDF
Zhuo Chen; Zhijie Li; Surendra Basti; William J. Farley; Stephen C. Pflugfelder
Tags: cornea, epithelium, language morphology, mice, mice, knockout
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5592-5600. doi:https://doi.org/10.1167/iovs.09-4562
Dependence of Resolvin-Induced Increases in Corneal Epithelial Cell Migration on EGF Receptor Transactivation Free
PDF
Fan Zhang; Hua Yang; Zan Pan; Zheng Wang; J. Mario Wolosin; Per Gjorstrup; Peter S. Reinach
Tags: epidermal growth factor receptors, trans-activation (genetics), mitogen-activated protein kinase p38, cell motility, corneal epithelial cells
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5601-5609. doi:https://doi.org/10.1167/iovs.09-4468
Standardization of Corneal Haze Measurement in Confocal Microscopy Free
PDF
Jay W. McLaren; William M. Bourne; Sanjay V. Patel
Tags: corneal opacity, microscopes, microscopy, confocal, cornea
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5610-5616. doi:https://doi.org/10.1167/iovs.10-5614
The Anti-oxidative Role of ABCG2 in Corneal Epithelial Cells Free
PDF
Miyuki Kubota; Shigeto Shimmura; Hideyuki Miyashita; Motoko Kawashima; Tetsuya Kawakita; Kazuo Tsubota
Tags: cornea, corneal epithelial cells, epithelial cells, hypoxia, mice
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5617-5622. doi:https://doi.org/10.1167/iovs.10-5463
Suppressive Effects of Azithromycin on Zymosan-Induced Production of Proinflammatory Mediators by Human Corneal Epithelial Cells Free
PDF
De-Quan Li; Nan Zhou; Lili Zhang; Ping Ma; Stephen C. Pflugfelder
Tags: azithromycin, corneal epithelial cells, zymosan, toll-like receptor 2, western blotting
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5623-5629. doi:https://doi.org/10.1167/iovs.09-4992
Corneal Epithelial Wound Healing Impaired in Keratinocyte-Specific HB-EGF–Deficient Mice In Vivo and In Vitro Free
PDF
Ryuji Yoshioka; Atsushi Shiraishi; Takeshi Kobayashi; Shin-ichi Morita; Yasuhito Hayashi; Shigeki Higashiyama; Yuichi Ohashi
Tags: cornea, epithelium, heparin-binding egf-like growth factor, mice, wound healing
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5630-5639. doi:https://doi.org/10.1167/iovs.10-5158
Interaction of Corneal Nociceptive Stimulation and Lacrimal Secretion Free
PDF
Ping Situ; Trefford L. Simpson
Tags: bodily secretions, cornea, stimulation, chemical, reflex
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5640-5645. doi:https://doi.org/10.1167/iovs.10-5502

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Effects of Recession versus Tenotomy Surgery without Recession in Adult Rabbit Extraocular Muscle Free
PDF
Stephen P. Christiansen; Rosalia S. Antunes-Foschini; Linda K. McLoon
Tags: muscle, muscle satellite cell, oryctolagus cuniculus, protein isoforms, superior rectus muscle
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5646-5656. doi:https://doi.org/10.1167/iovs.10-5523

Glaucoma

Predicting Visual Function from the Measurements of Retinal Nerve Fiber Layer Structure Free
PDF
Haogang Zhu; David P. Crabb; Patricio G. Schlottmann; Hans G. Lemij; Nicolaas J. Reus; Paul R. Healey; Paul Mitchell; Tuan Ho; David F. Garway-Heath
Tags: glaucoma, retinal nerve fiber layer, vision, scanning laser polarimetry, functional measures
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5657-5666. doi:https://doi.org/10.1167/iovs.10-5239
Utility of Digital Stereo Images for Optic Disc Evaluation Free
PDF
Richard A. Stone; Gui-shuang Ying; Denise J. Pearson; Mayank Bansal; Manika Puri; Eydie Miller; Judith Alexander; Jody Piltz-Seymour; William Nyberg; Maureen G. Maguire; Jayan Eledath; Harpreet Sawhney
Tags: color, optic disk, glaucoma
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5667-5674. doi:https://doi.org/10.1167/iovs.09-4999
Changes in the Biomechanical Response of the Optic Nerve Head in Early Experimental Glaucoma Free
PDF
Michael D. Roberts; Ian A. Sigal; Yi Liang; Claude F. Burgoyne; J. Crawford Downs
Tags: cercopithecidae, eye, glaucoma, intraocular pressure, optic disk
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5675-5684. doi:https://doi.org/10.1167/iovs.10-5411
Spatial Pattern of Glaucomatous Visual Field Loss Obtained with Regionally Condensed Stimulus Arrangements Free
PDF
Ulrich Schiefer; Eleni Papageorgiou; Pamela A. Sample; John P. Pascual; Bettina Selig; Elke Krapp; Jens Paetzold
Tags: glaucomatous visual field defect, visual fields, perimetry, glaucoma
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5685-5689. doi:https://doi.org/10.1167/iovs.09-5067
Quantification of the Effect of Different Levels of IOP in the Astroglia of the Rat Retina Ipsilateral and Contralateral to Experimental Glaucoma Free
PDF
Ana I. Ramírez; Juan J. Salazar; Rosa de Hoz; Blanca Rojas; Beatriz I. Gallego; Manuel Salinas-Navarro; Luis Alarcón-Martínez; Arturo Ortín-Martínez; Marcelino Avilés-Trigueros; Manuel Vidal-Sanz; Alberto Triviño; Jose M. Ramírez
Tags: astrocytes, eye, glaucoma, intraocular pressure, retina
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5690-5696. doi:https://doi.org/10.1167/iovs.10-5248
Glaucomatous Tissue Stress and the Regulation of Immune Response through Glial Toll-like Receptor Signaling Free
PDF
Cheng Luo; Xiangjun Yang; Angela D. Kain; David W. Powell; Markus H. Kuehn; Gülgün Tezel
Tags: glaucoma, signal transduction, stress, body tissue, immune response
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5697-5707. doi:https://doi.org/10.1167/iovs.10-5407
Automated Segmentation of Neural Canal Opening and Optic Cup in 3D Spectral Optical Coherence Tomography Volumes of the Optic Nerve Head Free
PDF
Zhihong Hu; Michael D. Abràmoff; Young H. Kwon; Kyungmoo Lee; Mona K. Garvin
Tags: optic cup, optic disk, optical coherence tomography, spinal canal, eye
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5708-5717. doi:https://doi.org/10.1167/iovs.09-4838
TGF-β2 Induces Senescence-Associated Changes in Human Trabecular Meshwork Cells Free
PDF
Alice L. Yu; Kerstin Birke; Jerome Moriniere; Ulrich Welge-Lüssen
Tags: aging, proteins, retinoblastoma protein, trabecular meshwork, older adult
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5718-5723. doi:https://doi.org/10.1167/iovs.10-5679
Reproducibility of Peripapillary Retinal Nerve Fiber Layer Thickness and Optic Nerve Head Parameters Measured with Cirrus HD-OCT in Glaucomatous Eyes Free
PDF
Jean-Claude Mwanza; Robert T. Chang; Donald L. Budenz; Mary K. Durbin; Mohamed G. Gendy; Wei Shi; William J. Feuer
Tags: eye, glaucoma, optic disk, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5724-5730. doi:https://doi.org/10.1167/iovs.10-5222
Oxygen Distribution in the Human Eye: Relevance to the Etiology of Open-Angle Glaucoma after Vitrectomy Free
PDF
Carla J. Siegfried; Ying-Bo Shui; Nancy M. Holekamp; Fang Bai; David C. Beebe
Tags: eye, oxygen, vitrectomy, portugal, open-angle glaucoma
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5731-5738. doi:https://doi.org/10.1167/iovs.10-5666
Circadian Variations in Intracranial Pressure and Translaminar Pressure Difference in Sprague-Dawley Rats Free
PDF
Jessica S. Lin; John H. K. Liu
Tags: intracranial pressure, rats, rats, sprague-dawley, intraocular pressure, physical activity
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5739-5743. doi:https://doi.org/10.1167/iovs.10-5542
A New Method for Selection of Angular Aqueous Plexus Cells from Porcine Eyes: A Model for Schlemm's Canal Endothelium Free
PDF
Yuan Lei; Darryl R. Overby; A. Thomas Read; W. Daniel Stamer; C. Ross Ethier
Tags: endothelium, eye, puromycin, schlemm's canal, suidae
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5744-5750. doi:https://doi.org/10.1167/iovs.10-5703
TRPC6 Channel Protects Retinal Ganglion Cells in a Rat Model of Retinal Ischemia/Reperfusion-Induced Cell Death Free
PDF
Xiaolei Wang; Leilei Teng; Ang Li; Jian Ge; Alan M. Laties; Xiulan Zhang
Tags: physiologic reperfusion, reperfusion therapy, retina, retinal ganglion cells, retinal ischemia
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5751-5758. doi:https://doi.org/10.1167/iovs.10-5451
Changes of Osteopontin in the Aqueous Humor of the DBA2/J Glaucoma Model Correlated with Optic Nerve and RGC Degenerations Free
PDF
Marco T. Birke; Carolin Neumann; Kerstin Birke; Jan Kremers; Michael Scholz
Tags: antibodies, aqueous humor, cytokine, eye, glaucoma
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5759-5767. doi:https://doi.org/10.1167/iovs.10-5558
Effect of Chondroitin Sulfate on Intraocular Pressure in Rats Free
PDF
Nicolás Belforte; Pablo Sande; Nuria de Zavalía; Paul A. Knepper; Ruth E. Rosenstein
Tags: chondroitin sulfates, eye, intraocular pressure, rats, glaucoma
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5768-5775. doi:https://doi.org/10.1167/iovs.10-5660

Immunology and Microbiology

VIP Promotes Resistance in the Pseudomonas aeruginosa–Infected Cornea by Modulating Adhesion Molecule Expression Free
PDF
Elizabeth A. Berger; Sharon A. McClellan; Ronald P. Barrett; Linda D. Hazlett
Tags: cell adhesion molecules, cornea, pseudomonas aeruginosa, mice, proteins
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5776-5782. doi:https://doi.org/10.1167/iovs.09-4917
Inhibition of B-Cell Activation by Retinal Pigment Epithelium Free
PDF
Sunao Sugita; Shintaro Horie; Yukiko Yamada; Manabu Mochizuki
Tags: b-cell activation, b-lymphocytes, retinal pigment cell, retinal pigment epithelium, cd40 antigens
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5783-5788. doi:https://doi.org/10.1167/iovs.09-5098

Multidisciplinary Ophthalmic Imaging

Retinal Structure of Birds of Prey Revealed by Ultra-High Resolution Spectral-Domain Optical Coherence Tomography Free
PDF
Marco Ruggeri; James C. Major, Jr; Craig McKeown; Robert W. Knighton; Carmen A. Puliafito; Shuliang Jiao
Tags: optical coherence tomography, raptors, retina, diagnostic imaging, eye
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5789-5795. doi:https://doi.org/10.1167/iovs.10-5633

Physiology and Pharmacology

Evaluating Retinal Toxicity of Intravitreal Caspofungin in the Mouse Eye Free
PDF
Deb K. Mojumder; Francis A. Concepcion; Shil K. Patel; Andrew J. Barkmeier; Petros E. Carvounis; John H. Wilson; Eric R. Holz; Theodore G. Wensel
Tags: caspofungin, eye, mice, retinal toxicity, balanced salt solutions
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5796-5803. doi:https://doi.org/10.1167/iovs.10-5541
Nanosized Dendritic Polyguanidilyated Translocators for Enhanced Solubility, Permeability, and Delivery of Gatifloxacin Free
PDF
Chandrasekar Durairaj; Rajendra S. Kadam; John W. Chandler; Stephen L. Hutcherson; Uday B. Kompella
Tags: dendrimers, diphtheria-tetanus-pertussis vaccine, gatifloxacin, solubility, permeability
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5804-5816. doi:https://doi.org/10.1167/iovs.10-5388
Endogenous Regulation of Human Schlemm's Canal Cell Volume by Nitric Oxide Signaling Free
PDF
Dorette Z. Ellis; Najam A. Sharif; William M. Dismuke
Tags: cell volume, nitric oxide, schlemm's canal, deet, signal transduction
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5817-5824. doi:https://doi.org/10.1167/iovs.09-5072
Parstatin Suppresses Ocular Neovascularization and Inflammation Free
PDF
Hu Huang; Panagiotis Vasilakis; Xiufeng Zhong; Ji-Kui Shen; Katerina Geronatsiou; Helen Papadaki; Michael E. Maragoudakis; Sotirios P. Gartaganis; Stanley A. Vinores; Nikos E. Tsopanoglou
Tags: corneal neovascularization, inflammation, mice, neovascularization, pathologic, retinal neovascularization
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5825-5832. doi:https://doi.org/10.1167/iovs.10-5576

Retina

Continuous Retinal Vessel Diameter Measurements: The Future in Retinal Vessel Assessment? Free
PDF
Rebekka Heitmar; Andrew D. Blann; Robert P. Cubbidge; Gregory Y. H. Lip; Doina Gherghel
Tags: diameter, photopsia, retinal vessels, smoking
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5833-5839. doi:https://doi.org/10.1167/iovs.09-5136
Macular Pigment Optical Density Measured by Dual-Wavelength Autofluorescence Imaging in Diabetic and Nondiabetic Patients: A Comparative Study Free
PDF
Verônica Castro Lima; Richard B. Rosen; Mauricio Maia; Tiago Santos Prata; Syril Dorairaj; Michel Eid Farah; Juliana Sallum
Tags: autofluorescence, diabetes mellitus, diagnostic imaging, optics, pigment
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5840-5845. doi:https://doi.org/10.1167/iovs.09-4695
Macular Pigment Optical Density Measured by Dual-Wavelength Autofluorescence Imaging in Diabetic and Nondiabetic Patients: A Comparative Study Free
PDF
Verônica Castro Lima; Richard B. Rosen; Mauricio Maia; Tiago Santos Prata; Syril Dorairaj; Michel Eid Farah; Juliana Sallum
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5840-5845. doi:https://doi.org/10.1167/iovs.09-4695
Digital versus Film Fundus Photography for Research Grading of Diabetic Retinopathy Severity Free
PDF
Helen K. Li; Larry D. Hubbard; Ronald P. Danis; Adol Esquivel; Jose F. Florez-Arango; Nicola J. Ferrier; Elizabeth A. Krupinski
Tags: diabetic retinopathy, fundus photography, eye, photography
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5846-5852. doi:https://doi.org/10.1167/iovs.09-4803
Characterization of Subretinal Fluid Leakage in Central Serous Chorioretinopathy Free
PDF
Anders Pryds; Birgit Sander; Michael Larsen
Tags: angiogram, central serous chorioretinopathy, fluorescein
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5853-5857. doi:https://doi.org/10.1167/iovs.09-4830
Complement Factor H Autoantibodies and Age-Related Macular Degeneration Free
PDF
Baljean Dhillon; Alan F. Wright; Adnan Tufail; Isabel Pappworth; Caroline Hayward; Iain Moore; Lisa Strain; David Kavanagh; Paul N. Barlow; Andrew P. Herbert; Christoph Q. Schmidt; Ana-Maria Armbrecht; Augustinus Laude; Ian J. Deary; Scott J. Staniforth; Lucy V. Holmes; Timothy H. J. Goodship; Kevin J. Marchbank
Tags: age-related macular degeneration, autoantibodies, complement factor h
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5858-5863. doi:https://doi.org/10.1167/iovs.09-5124
Correlation of Histologic and Clinical Images to Determine the Diagnostic Value of Fluorescein Angiography for Studying Retinal Capillary Detail Free
PDF
Kanishka R. Mendis; Chandrakumar Balaratnasingam; Paula Yu; Chris J. Barry; Ian L. McAllister; Stephen J. Cringle; Dao-Yi Yu
Tags: blood capillaries, fluorescein angiography
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5864-5869. doi:https://doi.org/10.1167/iovs.10-5333
Automated Quantification of Inherited Phenotypes from Color Images: A Twin Study of the Variability of Optic Nerve Head Shape Free
PDF
Li Tang; Todd E. Scheetz; David A. Mackey; Alex W. Hewitt; John H. Fingert; Young H. Kwon; Gwenole Quellec; Joseph M. Reinhardt; Michael D. Abràmoff
Tags: optic disk, phenotype, color, twins, twin studies
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5870-5877. doi:https://doi.org/10.1167/iovs.10-5527
Transgenic Mice Expressing Variants of Complement Factor H Develop AMD-like Retinal Findings Free
PDF
Rafael L. Ufret-Vincenty; Bogale Aredo; Xinran Liu; Anne McMahon; Peter W. Chen; Hui Sun; Jerry Y. Niederkorn; Wojciech Kedzierski
Tags: chimera organism, complement factor h, mice, mice, transgenic, animals, transgenic
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5878-5887. doi:https://doi.org/10.1167/iovs.09-4457
Immune Activation in Retinal Aging: A Gene Expression Study Free
PDF
Mei Chen; Elizabeth Muckersie; John V. Forrester; Heping Xu
Tags: aging, genes, genes, vif, mice, retina
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5888-5896. doi:https://doi.org/10.1167/iovs.09-5103
The Respective Relationships between Lipoprotein Profile, Macular Pigment Optical Density, and Serum Concentrations of Lutein and Zeaxanthin Free
PDF
Edward Loane; John M. Nolan; Stephen Beatty
Tags: lipoproteins, lutein, mass or substance concentration per volume, optics, pigment
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5897-5905. doi:https://doi.org/10.1167/iovs.09-4878
Outgrowth Endothelial Cells: Characterization and Their Potential for Reversing Ischemic Retinopathy Free
PDF
Reinhold J. Medina; Christina L. O'Neill; Mervyn W. Humphreys; Tom A. Gardiner; Alan W. Stitt
Tags: endothelial cells, ischemia, retinal diseases, endothelium, vascular repairs
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5906-5913. doi:https://doi.org/10.1167/iovs.09-4951
CFH and ARMS2 Variations in Age-Related Macular Degeneration, Polypoidal Choroidal Vasculopathy, and Retinal Angiomatous Proliferation Free
PDF
Hisako Hayashi; Kenji Yamashiro; Norimoto Gotoh; Hideo Nakanishi; Isao Nakata; Akitaka Tsujikawa; Atsushi Otani; Masaaki Saito; Tomohiro Iida; Keitaro Matsuo; Kazuo Tajima; Ryo Yamada; Nagahisa Yoshimura
Tags: age-related macular degeneration, polymorphism, vascular diseases, alleles, cfh y402h
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5914-5919. doi:https://doi.org/10.1167/iovs.10-5554
Effects of Ischemic Preconditioning and Bevacizumab on Apoptosis and Vascular Permeability Following Retinal Ischemia–Reperfusion Injury Free
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Steven F. Abcouwer; Cheng-mao Lin; Ellen B. Wolpert; Sumathi Shanmugam; Eric W. Schaefer; Willard M. Freeman; Alistair J. Barber; David A. Antonetti
Tags: apoptosis, bevacizumab, ischemia, ischemic preconditioning, nerve degeneration
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5920-5933. doi:https://doi.org/10.1167/iovs.10-5264
GTx-822, an ERβ-Selective Agonist, Protects Retinal Pigment Epithelium (ARPE-19) from Oxidative Stress by Activating MAPK and PI3-K Pathways Free
PDF
Anand Giddabasappa; Matthew N. Bauler; Christina M. Barrett; Christopher C. Coss; Zhongzhi Wu; Duane D. Miller; James T. Dalton; Jeetendra R. Eswaraka
Tags: agonists, mitochondria, mitogen-activated protein kinases, oxidative stress, retinal pigment epithelium
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5934-5942. doi:https://doi.org/10.1167/iovs.10-5630
Homozygosity Mapping in Patients with Cone–Rod Dystrophy: Novel Mutations and Clinical Characterizations Free
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Karin W. Littink; Robert K. Koenekoop; L. Ingeborgh van den Born; Rob W. J. Collin; Luminita Moruz; Joris A. Veltman; Susanne Roosing; Marijke N. Zonneveld; Amer Omar; Mahshad Darvish; Irma Lopez; Hester Y. Kroes; Maria M. van Genderen; Carel B. Hoyng; Klaus Rohrschneider; Mary J. van Schooneveld; Frans P. M. Cremers; Anneke I. den Hollander
Tags: homozygote, mutation, progressive cone-rod dystrophy, retinitis pigmentosa
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5943-5951. doi:https://doi.org/10.1167/iovs.10-5797
Progressive Loss of Cones in Achromatopsia: An Imaging Study Using Spectral-Domain Optical Coherence Tomography Free
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Alberta A. H. J. Thiadens; Ville Somervuo; L. Ingeborgh van den Born; Susanne Roosing; Mary J. van Schooneveld; Robert W. A. M. Kuijpers; Norka van Moll-Ramirez; Frans P. M. Cremers; Carel B. Hoyng; Caroline C. W. Klaver
Tags: achromatopsia, diagnostic imaging, optical coherence tomography, retinal cone, foveal hypoplasia
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5952-5957. doi:https://doi.org/10.1167/iovs.10-5680
Effective and Sustained Delivery of Hydrophobic Retinoids to Photoreceptors Free
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Peter H. Tang; Jie Fan; Patrice W. Goletz; Lee Wheless; Rosalie K. Crouch
Tags: hydrophobicity, mice, photoreceptors, retinal cone, retinoids
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5958-5964. doi:https://doi.org/10.1167/iovs.10-5766
Small Dense Particles in the Retina Observable by Spectral-Domain Optical Coherence Tomography in Age-Related Macular Degeneration Free
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Carsten Framme; Sebastian Wolf; Ute Wolf-Schnurrbusch
Tags: age-related macular degeneration, optical coherence tomography, ranibizumab, retina, exudative age-related macular degeneration
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5965-5969. doi:https://doi.org/10.1167/iovs.10-5779

Retinal Cell Biology

Generation of Retinal Ganglion–like Cells from Reprogrammed Mouse Fibroblasts Free
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Mengfei Chen; Qin Chen; Xuerong Sun; Wenjuan Shen; Bingqian Liu; Xiufeng Zhong; Yunxia Leng; Chunmei Li; Weizhong Zhang; Fang Chai; Bing Huang; Qianying Gao; Andy Peng Xiang; Yehong Zhuo; Jian Ge
Tags: fibroblasts, genes, mice, protein overexpression, retina
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5970-5978. doi:https://doi.org/10.1167/iovs.09-4504
Diabetes-Induced Inhibition of Voltage-Dependent Calcium Channels in the Retinal Microvasculature: Role of Spermine Free
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Kenji Matsushita; Masanori Fukumoto; Takatoshi Kobayashi; Masato Kobayashi; Eisuke Ishizaki; Masahiro Minami; Kozo Katsumura; Sophie D. Liao; David M. Wu; Ting Zhang; Donald G. Puro
Tags: calcium channels, diabetes mellitus, retinal vasculature, spermine, blood capillaries
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5979-5990. doi:https://doi.org/10.1167/iovs.10-5377
A Conditional Immortalized Mouse Müller Glial Cell Line Expressing Glial and Retinal Stem Cell Genes Free
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Deborah C. Otteson; M. Joseph Phillips
Tags: cell lines, genes, mice, neuroglia, stem cells
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5991-6000. doi:https://doi.org/10.1167/iovs.10-5395
Heat-Sensitive TRPV Channels in Retinal Pigment Epithelial Cells: Regulation of VEGF-A Secretion Free
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Sönke Cordeiro; Sebastian Seyler; Julia Stindl; Vladimir M. Milenkovic; Olaf Strauss
Tags: bodily secretions, heat (physical force), insulin-like growth factor i, retinal pigment cell, trpv cation channels
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 6001-6008. doi:https://doi.org/10.1167/iovs.09-4720
A Subretinal Matrigel Rat Choroidal Neovascularization (CNV) Model and Inhibition of CNV and Associated Inflammation and Fibrosis by VEGF Trap Free
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Jingtai Cao; Lian Zhao; Yiwen Li; Yang Liu; Weihong Xiao; Ying Song; Lingyu Luo; Deqiang Huang; George D. Yancopoulos; Stanley J. Wiegand; Rong Wen
Tags: choroidal neovascularization, fibrosis, inflammation, thyroid hormone associated protein complex, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 6009-6017. doi:https://doi.org/10.1167/iovs.09-4956
Comparative Effects of Six Intraocular Vital Dyes on Retinal Pigment Epithelial Cells Free
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María-Celia Morales; Vanesa Freire; Aintzane Asumendi; Javier Araiz; Itxaso Herrera; Gonzalo Castiella; Iñigo Corcóstegui; Gonzalo Corcóstegui
Tags: dyes, toxic effect, retinal pigment cell
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 6018-6029. doi:https://doi.org/10.1167/iovs.09-4916
Induction of Lysosomal Dilatation, Arrested Autophagy, and Cell Death by Chloroquine in Cultured ARPE-19 Cells Free
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Young Hee Yoon; Kyung Sook Cho; Jung Jin Hwang; Sook-Jeong Lee; Jeong A. Choi; Jae-Young Koh
Tags: autophagy, cell death, chloroquine, dilatation, pathologic, proteins
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 6030-6037. doi:https://doi.org/10.1167/iovs.10-5278
Transcriptional Profile Analysis of RPGRORF15 Frameshift Mutation Identifies Novel Genes Associated with Retinal Degeneration Free
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Sem Genini; Barbara Zangerl; Julianna Slavik; Gregory M. Acland; William A. Beltran; Gustavo D. Aguirre
Tags: genes, retina
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 6038-6050. doi:https://doi.org/10.1167/iovs.10-5443

Visual Neuroscience

PKCα Is Essential for the Proper Activation and Termination of Rod Bipolar Cell Response Free
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Klaus Ruether; Andreas Feigenspan; Judith Pirngruber; Michael Leitges; Wolfgang Baehr; Olaf Strauss
Tags: electroretinography, mice, retinal bipolar cells, rod photoreceptors
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 6051-6058. doi:https://doi.org/10.1167/iovs.09-4704

Visual Psychophysics and Physiological Optics

Peripheral Refraction in Different Ethnicities Free
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Pauline Kang; Paul Gifford; Philomena McNamara; Jenny Wu; Stephanie Yeo; Bonney Vong; Helen Swarbrick
Tags: ethnic group, refraction, asian, corneal topography, myopia
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 6059-6065. doi:https://doi.org/10.1167/iovs.09-4747
Enhancement of Resolution Acuity in a Half-Binocular Viewing Condition Free
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Ximena Masgoret; Lisa Asper; Jack Alexander; Catherine Suttle
Tags: eye, summation, luminance, vision, adult
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 6066-6069. doi:https://doi.org/10.1167/iovs.09-4896
Center-Surround Visual Motion Processing in Migraine Free
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Josephine Battista; David R. Badcock; Allison M. McKendrick
Tags: migraine disorders, motion
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 6070-6076. doi:https://doi.org/10.1167/iovs.10-5290
A Relationship between Tolerance of Blur and Personality Free
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Russell L. Woods; C. Randall Colvin; Fuensanta A. Vera-Diaz; Eli Peli
Tags: personality
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 6077-6082. doi:https://doi.org/10.1167/iovs.09-5013

Clinical Trials

Risk Factors for Corneal Infiltrative Events during Continuous Wear of Silicone Hydrogel Contact Lenses Free
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Loretta Szczotka-Flynn; Jonathan H. Lass; Ajay Sethi; Sara Debanne; Beth Ann Benetz; Matthew Albright; Beth Gillespie; Jana Kuo; Michael R. Jacobs; Alfred Rimm
Tags: contact lenses, cornea, hydrogel, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5421-5430. doi:https://doi.org/10.1167/iovs.10-5456
Effects of Retinal Morphology on Contrast Sensitivity and Reading Ability in Neovascular Age-Related Macular Degeneration Free
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Pearse A. Keane; Praveen J. Patel; Yanling Ouyang; Fred K. Chen; Felicia Ikeji; Alexander C. Walsh; Adnan Tufail; Srinivas R. Sadda
Tags: contrast sensitivity, exudative age-related macular degeneration, language morphology, morphology, reading ability
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5431-5437. doi:https://doi.org/10.1167/iovs.09-4846

Research Opportunities

Corneal Dystrophies: Molecular Genetics to Therapeutic Intervention—Fifth ARVO/Pfizer Ophthalmics Research Institute Conference Free
PDF
Jayne S. Weiss; the Fifth ARVO/Pfizer Ophthalmics Research Institute Conference Working Group
Tags: hereditary corneal dystrophy, genetics, molecular, therapeutic intervention
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5391-5402. doi:https://doi.org/10.1167/iovs.09-4746
Ophthalmic Drug Delivery Systems for the Treatment of Retinal Diseases: Basic Research to Clinical Applications Free
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Henry F. Edelhauser; Cheryl L. Rowe-Rendleman; Michael R. Robinson; Daniel G. Dawson; Gerald J. Chader; Hans E. Grossniklaus; Kay D. Rittenhouse; Clive G. Wilson; David A. Weber; Baruch D. Kuppermann; Karl G. Csaky; Timothy W. Olsen; Uday B. Kompella; V. Michael Holers; Gregory S. Hageman; Brian C. Gilger; Peter A. Campochiaro; Scott M. Whitcup; Wai T. Wong
Tags: drug clearance, drug delivery systems, eye, ophthalmic agents, retinal diseases
Investigative Ophthalmology & Visual Science November 2010, Vol.51, 5403-5420. doi:https://doi.org/10.1167/iovs.10-5392
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