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Anatomy and Pathology/Oncology

Focal, Periocular Delivery of 2-Deoxy-d-Glucose as Adjuvant to Chemotherapy for Treatment of Advanced Retinoblastoma Free
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Yolanda Piña; Samuel K. Houston; Timothy G. Murray; Hinda Boutrid; Magda Celdran; William Feuer; Wei Shi; Eleut Hernandez; Theodore J. Lampidis
Tags: carboplatin, chemotherapy regimen, glucose, hypoxia, immunologic adjuvants
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6149-6156. doi:https://doi.org/10.1167/iovs.09-5033
Novel Discovery of LYVE-1 Expression in the Hyaloid Vascular System Free
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Hui Zhang; Julie Tse; Xuemei Hu; Marlys Witte; Michael Bernas; Jinjoo Kang; Firehiwott Tilahun; Young-Kwon Hong; Mengsheng Qiu; Lu Chen
Tags: antibodies, cd31 antigens, macrophages, vascular system, mice
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6157-6161. doi:https://doi.org/10.1167/iovs.10-5205
Effect of Induced Myopia on Scleral Myofibroblasts and In Vivo Ocular Biomechanical Compliance in the Guinea Pig Free
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Simon Backhouse; John R. Phillips
Tags: biomechanical compliance, eye, guinea, myofibroblasts, myopia
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6162-6171. doi:https://doi.org/10.1167/iovs.10-5387
Increased Hyaluronan Synthase-2 mRNA Expression and Hyaluronan Accumulation with Choroidal Thickening: Response during Recovery from Induced Myopia Free
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Jody A. Summers Rada; Allan F. Wiechmann; Lindsey R. Hollaway; Bruce A. Baggenstoss; Paul H. Weigel
Tags: choroid, eye, hyaluronan, myopia, recovery of function
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6172-6179. doi:https://doi.org/10.1167/iovs.10-5522
Lack of Oncogenic GNAQ Mutations in Melanocytic Lesions of the Conjunctiva as Compared to Uveal Melanoma Free
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Olga Dratviman-Storobinsky; Yoram Cohen; Shahar Frenkel; Jacob Pe'er; Nitza Goldenberg-Cohen
Tags: conjunctiva, mutation, uveal melanoma
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6180-6182. doi:https://doi.org/10.1167/iovs.10-5677

Biochemistry and Molecular Biology

Joint Effect of Cigarette Smoking and CFH and LOC387715/HTRA1 Polymorphisms on Polypoidal Choroidal Vasculopathy Free
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Hideo Nakanishi; Kenji Yamashiro; Ryo Yamada; Norimoto Gotoh; Hisako Hayashi; Isao Nakata; Masaaki Saito; Tomohiro Iida; Akio Oishi; Yasuo Kurimoto; Keitaro Matsuo; Kazuo Tajima; Fumihiko Matsuda; Nagahisa Yoshimura
Tags: htra1 gene, polymorphism, smoking, vascular diseases, cfh y402h
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6183-6187. doi:https://doi.org/10.1167/iovs.09-4948
Enhancement of Angiogenic Potential of Endothelial Cells by Contact with Retinal Pigment Epithelial Cells in a Model Simulating Pathological Conditions Free
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Rima Dardik; Tami Livnat; Yael Nisgav; Dov Weinberger
Tags: angiogenesis, coculture techniques, electroconvulsive therapy, epidural cortical stimulation, retinal pigment cell
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6188-6195. doi:https://doi.org/10.1167/iovs.09-5095
Neovascularization, Enhanced Inflammatory Response, and Age-Related Cone Dystrophy in the Nrl −/− Grk1 −/− Mouse Retina Free
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Rosanne M. Yetemian; Bruce M. Brown; Cheryl M. Craft
Tags: cone dystrophy, inflammatory response, mice, neovascularization, pathologic, retina
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6196-6206. doi:https://doi.org/10.1167/iovs.10-5452
Retinal Gene Expression after Central Retinal Artery Ligation: Effects of Ischemia and Reperfusion Free
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Shiv S. Prasad; Ljubomir Kojic; Yan H. Wen; Zheng Chen; Wei Xiong; William Jia; Max S. Cynader
Tags: central retinal artery, gene expression, genes, ischemia, ligation
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6207-6219. doi:https://doi.org/10.1167/iovs.10-5632
Shotgun Lipidomic Analysis of Human Meibomian Gland Secretions with Electrospray Ionization Tandem Mass Spectrometry Free
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Jianzhong Chen; Kari B. Green-Church; Kelly K. Nichols
Tags: bodily secretions, ionization, lipids, meibomian gland, tandem mass spectrometry
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6220-6231. doi:https://doi.org/10.1167/iovs.10-5687
Potentiation of Bortezomib-Induced Apoptosis by TGF-β in Cultured Human Tenon's Fibroblasts: Contribution of the PI3K/Akt Signaling Pathway Free
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Eun Jee Chung; Sang Woong Moon; Sun-Ah Jung; Young Jae Cho; Si Wouk Kim; Joon H. Lee
Tags: bortezomib, combined modality therapy, apoptosis, fibroblasts, 1-phosphatidylinositol 3-kinase
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6232-6237. doi:https://doi.org/10.1167/iovs.10-5747

Clinical and Epidemiologic Research

Association of Interleukin-1β (IL1B) Polymorphisms with Graves' Ophthalmopathy in Taiwan Chinese Patients Free
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Yu-Huei Liu; Rong-Hsing Chen; Hsin-Hung Wu; Wen-Ling Liao; Wen-Chi Chen; Yuhsin Tsai; Chang-Hai Tsai; Lei Wan; Fuu-Jen Tsai
Tags: graves' ophthalmopathy, interleukin-1, polymorphism, interleukins, taiwan
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6238-6246. doi:https://doi.org/10.1167/iovs.09-4965
Hyperopic Refractive Error and Shorter Axial Length Are Associated with Age-Related Macular Degeneration: The Singapore Malay Eye Study Free
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Raghavan Lavanya; Ryo Kawasaki; Wan Ting Tay; Gemmy C. M. Cheung; Paul Mitchell; Seang-Mei Saw; Tin Aung; Tien Y. Wong
Tags: age-related macular degeneration, eye, refractive errors, singapore, hyperopia
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6247-6252. doi:https://doi.org/10.1167/iovs.10-5229
Prevalence and Risk Factors for Cataract in Diabetes: Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetics Study, Report No. 17 Free
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Rajiv Raman; Swakshyar Saumya Pal; James Subrat Kumar Adams; Padmaja Kumari Rani; Kulothungan Vaitheeswaran; Tarun Sharma
Tags: cataract, diabetes mellitus, diabetes mellitus, type 2, risk factors, prevalence
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6253-6261. doi:https://doi.org/10.1167/iovs.10-5414
Human Optical Axial Length and Defocus Free
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Scott A. Read; Michael J. Collins; Beata P. Sander
Tags: eye, optics, refractive errors, lens (device), significance
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6262-6269. doi:https://doi.org/10.1167/iovs.10-5457
Ethnic Differences in the Prevalence of Myopia and Ocular Biometry in 10- and 11-Year-Old Children: The Child Heart and Health Study in England (CHASE) Free
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Alicja R. Rudnicka; Christopher G. Owen; Claire M. Nightingale; Derek G. Cook; Peter H. Whincup
Tags: biometry, child, ethnic differences, myopia, prevalence
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6270-6276. doi:https://doi.org/10.1167/iovs.10-5528

Cornea

The Different Effects of Early and Late Bevacizumab (Avastin) Injection on Inhibiting Corneal Neovascularization and Conjunctivalization in Rabbit Limbal Insufficiency Free
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Chung-Tien Lin; Fung-Rong Hu; Kuang-Tzu Kuo; Yan-Ming Chen; Hsiao-Sang Chu; Ying-Han Lin; Wei-Li Chen
Tags: bevacizumab, cornea, corneal neovascularization, wounds and injuries, oryctolagus cuniculus
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6277-6285. doi:https://doi.org/10.1167/iovs.09-4571
Downregulation of Matrix Metalloproteinase–2 in Corneal Fibroblasts by Interleukin-1 Receptor Antagonist Released from Corneal Epithelial Cells Free
PDF
Ji-Ae Ko; Ryoji Yanai; Tai-ichiro Chikama; Teruo Nishida
Tags: chronic fatigue syndrome, cornea, corneal epithelial cells, down-regulation, fibroblasts
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6286-6293. doi:https://doi.org/10.1167/iovs.09-4753
Evidence for the Major Contribution of Evaporation to Tear Film Thinning between Blinks Free
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Samuel H. Kimball; P. Ewen King-Smith; Jason J. Nichols
Tags: evaporation, tear film finding, dry eye syndromes
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6294-6297. doi:https://doi.org/10.1167/iovs.09-4772
Age-Severity Relationships in Families Linked to FCD2 with Retroillumination Photography Free
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Elyse J. McGlumphy; William S. Yeo; S. Amer Riazuddin; Amr Al-Saif; Jiangxia Wang; Allen O. Eghrari; Danielle N. Meadows; David G. Emmert; Nicholas Katsanis; John D. Gottsch
Tags: family, photography
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6298-6302. doi:https://doi.org/10.1167/iovs.10-5187
Alignment and Cell-Matrix Interactions of Human Corneal Endothelial Cells on Nanostructured Collagen Type I Matrices Free
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Rita Gruschwitz; Jens Friedrichs; Monika Valtink; Clemens M. Franz; Daniel J. Müller; Richard H. W. Funk; Katrin Engelmann
Tags: collagen, collagen type i, cornea, endothelial cells, integrins
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6303-6310. doi:https://doi.org/10.1167/iovs.10-5368
Selective Activation of the Prostaglandin E2 Circuit in Chronic Injury-Induced Pathologic Angiogenesis Free
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Elvira L. Liclican; Van Nguyen; Aaron B. Sullivan; Karsten Gronert
Tags: neovascularization, pathologic, prostaglandins e, wounds and injuries, cornea, inflammation
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6311-6320. doi:https://doi.org/10.1167/iovs.10-5455
Identification of the Raf-1 Signaling Pathway Used by cAMP to Inhibit p42/p44 MAPK in Rat Lacrimal Gland Acini: Role in Potentiation of Protein Secretion Free
PDF
Chika Funaki; Robin R. Hodges; Darlene A. Dartt
Tags: cyclic amp, mitogen-activated protein kinases, lacrimal gland, protein secretion, potentiation
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6321-6328. doi:https://doi.org/10.1167/iovs.10-5690
Removal of Biofilm from Contact Lens Storage Cases Free
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Yvonne T. Wu; Hua Zhu; Mark Willcox; Fiona Stapleton
Tags: biofilms, contact lens storage case, bacteria
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6329-6333. doi:https://doi.org/10.1167/iovs.10-5796
In Vitro Lipid Deposition on Hydrogel and Silicone Hydrogel Contact Lenses Free
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Andrew D. Pucker; Mirunalni Thangavelu; Jason J. Nichols
Tags: cholesterol, contact lenses, hydrogel, lecithin, lipids
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6334-6340. doi:https://doi.org/10.1167/iovs.10-5836

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Postural Stability Changes during the Prism Adaptation Test in Patients with Intermittent and Constant Exotropia Free
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Toshihiko Matsuo; Akiko Yabuki; Kayoko Hasebe; Yoshie Hirai Shira; Sayuri Imai; Hiroshi Ohtsuki
Tags: exotropia, constant, prisms, intermittent exotropia, eye
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6341-6347. doi:https://doi.org/10.1167/iovs.10-5840
Effects of Anisometropic Amblyopia on Visuomotor Behavior, I: Saccadic Eye Movements Free
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Ewa Niechwiej-Szwedo; Herbert C. Goltz; Manokaraananthan Chandrakumar; Zahra A. Hirji; Agnes M. F. Wong
Tags: anisometropic amblyopia, saccades, amblyopia, eye
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6348-6354. doi:https://doi.org/10.1167/iovs.10-5882
Myosin Heavy Chain Expression in Mouse Extraocular Muscle: More Complex Than Expected Free
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Yuefang Zhou; Dan Liu; Henry J. Kaminski
Tags: adult, mice, muscle of orbit, myosin heavy chains, protein isoforms
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6355-6363. doi:https://doi.org/10.1167/iovs.10-5937
Glucose Uptake in Rat Extraocular Muscles: Effect of Insulin and Contractile Activity Free
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Mary L. Garcia-Cazarin; Tatijana M. Fisher; Francisco H. Andrade
Tags: glucose uptake, insulin, muscle contraction, muscle of orbit, proto-oncogene proteins c-akt
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6364-6368. doi:https://doi.org/10.1167/iovs.10-6081

Genetics

A Novel ADAMTSL4 Mutation in Autosomal Recessive Ectopia Lentis et Pupillae Free
PDF
Anne E. Christensen; Torunn Fiskerstrand; Per M. Knappskog; Helge Boman; Eyvind Rødahl
Tags: autosomal recessive inheritance, ectopia lentis, mutation, homozygote, family
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6369-6373. doi:https://doi.org/10.1167/iovs.10-5597
Engineered Zinc Finger Nuclease–Mediated Homologous Recombination of the Human Rhodopsin Gene Free
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David L. Greenwald; Siobhan M. Cashman; Rajendra Kumar-Singh
Tags: recombination, genetic, rhodopsin, genes, zinc fingers, polymerase chain reaction
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6374-6380. doi:https://doi.org/10.1167/iovs.10-5781
Association of Glutathione S-Transferases Polymorphisms (GSTM1 and GSTT1) with Senile Cataract: A Meta-analysis Free
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Lei Sun; Bo Xi; Lei Yu; Xiang-Chun Gao; De-Jing Shi; Yin-Kun Yan; Dong-Jiang Xu; Qing Han; Chunyu Wang
Tags: cataract, senile, glutathione s-transferase, meta-analysis, polymorphism
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6381-6386. doi:https://doi.org/10.1167/iovs.10-5815

Glaucoma

Altered Calcium Signaling in an Experimental Model of Glaucoma Free
PDF
Minna Niittykoski; Giedrius Kalesnykas; Kim P. Larsson; Kai Kaarniranta; Karl E. O. Åkerman; Hannu Uusitalo
Tags: glaucoma, calcium signaling, eye, diagnostic imaging, intraocular pressure
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6387-6393. doi:https://doi.org/10.1167/iovs.09-3816
Intravitreal Injections of Neurotrophic Factors Secreting Mesenchymal Stem Cells Are Neuroprotective in Rat Eyes following Optic Nerve Transection Free
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Hani Levkovitch-Verbin; Ofer Sadan; Shelly Vander; Mordechai Rosner; Yael Barhum; Eldad Melamed; Daniel Offen; Shlomo Melamed
Tags: eye, intravitreal injections, mesenchymal stem cells, nerve growth factors, neuroprotective effect
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6394-6400. doi:https://doi.org/10.1167/iovs.09-4310
Relationship between Visual Field Sensitivity and Macular Ganglion Cell Complex Thickness as Measured by Spectral-Domain Optical Coherence Tomography Free
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Jung Woo Cho; Kyung Rim Sung; Suhwan Lee; Sung-Cheol Yun; Sung Yong Kang; Jaewan Choi; Jung Hwa Na; Youngrok Lee; Michael S. Kook
Tags: ganglia, glaucoma, optical coherence tomography, retinal nerve fiber layer, visual fields
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6401-6407. doi:https://doi.org/10.1167/iovs.09-5035
In-Vivo Microstructural Anatomy of β-Zone Parapapillary Atrophy in Glaucoma Free
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Sung Chul Park; Carlos Gustavo V. De Moraes; Celso Tello; Jeffrey M. Liebmann; Robert Ritch
Tags: atrophy, eye, glaucoma, optic disk, photoreceptors
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6408-6413. doi:https://doi.org/10.1167/iovs.09-5100
Effects of Acutely Elevated Hydrostatic Pressure in a Rat Ex Vivo Retinal Preparation Free
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Makoto Ishikawa; Takeshi Yoshitomi; Charles F. Zorumski; Yukitoshi Izumi
Tags: edema, glutamate, glutamates, retina, hydrostatic pressure
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6414-6423. doi:https://doi.org/10.1167/iovs.09-5127
Structure–Function Relationships in Normal and Glaucomatous Eyes Determined by Time- and Spectral-Domain Optical Coherence Tomography Free
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Jong Rak Lee; Jin Wook Jeoung; Jaewan Choi; Jin Young Choi; Ki Ho Park; Yeon-deok Kim
Tags: eye, glaucoma, optical coherence tomography, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6424-6430. doi:https://doi.org/10.1167/iovs.09-5130
Structure–Function Relationships in Normal and Glaucomatous Eyes Determined by Time- and Spectral-Domain Optical Coherence Tomography Free
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Jong Rak Lee; Jin Wook Jeoung; Jaewan Choi; Jin Young Choi; Ki Ho Park; Yeon-deok Kim
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6424-6430. doi:https://doi.org/10.1167/iovs.09-5130
Morphometric Changes in the Rat Optic Nerve Following Short-term Intermittent Elevations in Intraocular Pressure Free
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Karen M. Joos; Chun Li; Rebecca M. Sappington
Tags: intraocular pressure, optic nerve, eye, did not receive therapy or drug
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6431-6440. doi:https://doi.org/10.1167/iovs.10-5212
Multiplex Cytokine Analysis Reveals Elevated Concentration of Interleukin-8 in Glaucomatous Aqueous Humor Free
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John Kuchtey; Kasra A. Rezaei; Pimkwan Jaru-Ampornpan; Paul Sternberg, Jr; Rachel W. Kuchtey
Tags: cytokine, glaucoma, hypertension, interleukin-8, mass or substance concentration per volume
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6441-6447. doi:https://doi.org/10.1167/iovs.10-5216
Microglial Activation in the Visual Pathway in Experimental Glaucoma: Spatiotemporal Characterization and Correlation with Axonal Injury Free
PDF
Andreas Ebneter; Robert J. Casson; John P. M. Wood; Glyn Chidlow
Tags: glaucoma, wounds and injuries, microglia, visual pathways
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6448-6460. doi:https://doi.org/10.1167/iovs.10-5284
Characterization of Cytoskeleton-Enriched Protein Fraction of the Trabecular Meshwork and Ciliary Muscle Cells Free
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Toshihiro Inoue; Paula Pecen; Rupalatha Maddala; Nikolai P. Skiba; Padmanabhan P. Pattabiraman; David L. Epstein; P. Vasantha Rao
Tags: cytoskeletal proteins, cytoskeleton, proteins, ciliary muscle, trabecular meshwork
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6461-6471. doi:https://doi.org/10.1167/iovs.10-5318
An In Silico Model of Scanning Laser Tomography Image Series: An Alternative Benchmark for the Specificity of Progression Algorithms Free
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Neil O'Leary; David P. Crabb; David F. Garway-Heath
Tags: benchmarking, eye, eye movement, glaucoma, lasers
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6472-6482. doi:https://doi.org/10.1167/iovs.10-5355
Intralysosomal Iron Induces Lysosomal Membrane Permeabilization and Cathepsin D–Mediated Cell Death in Trabecular Meshwork Cells Exposed to Oxidative Stress Free
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Yizhi Lin; David L. Epstein; Paloma B. Liton
Tags: cathepsin d, cell death, iron, oxidative stress, suidae
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6483-6495. doi:https://doi.org/10.1167/iovs.10-5410
Increased Intraocular Pressure in Mice Treated with Dexamethasone Free
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N. Andrew Whitlock; Beth McKnight; Katie N. Corcoran; Lawrence A. Rodriguez; Dennis S. Rice
Tags: dexamethasone, intraocular pressure, mice, raised intraocular pressure, steroids
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6496-6503. doi:https://doi.org/10.1167/iovs.10-5430
Tracking Longitudinal Retinal Changes in Experimental Ocular Hypertension Using the cSLO and Spectral Domain-OCT Free
PDF
Li Guo; Eduardo M. Normando; Shereen Nizari; David Lara; M. Francesca Cordeiro
Tags: eye, glaucoma, intraocular pressure, ocular hypertension, retina
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6504-6513. doi:https://doi.org/10.1167/iovs.10-5551
Corneal Hysteresis and Visual Field Asymmetry in Open Angle Glaucoma Free
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Aashish Anand; Carlos Gustavo V. De Moraes; Christopher C. Teng; Celso Tello; Jeffrey M. Liebmann; Robert Ritch
Tags: corneal hysteresis, eye, open-angle glaucoma, visual fields, intraocular pressure
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6514-6518. doi:https://doi.org/10.1167/iovs.10-5580
Reproducibility of Spectral-Domain Optical Coherence Tomography Total Retinal Thickness Measurements in Mice Free
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Michelle L. Gabriele; Hiroshi Ishikawa; Joel S. Schuman; Richard A. Bilonick; Jongsick Kim; Larry Kagemann; Gadi Wollstein
Tags: mice, optical coherence tomography, eye
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6519-6523. doi:https://doi.org/10.1167/iovs.10-5662
Antifibrotic Activity of Bevacizumab on Human Tenon's Fibroblasts In Vitro Free
PDF
Evelyn C. O'Neill; Queena Qin; Nicole J. Van Bergen; Paul P. Connell; Sushil Vasudevan; Michael A. Coote; Ian A. Trounce; Tina T. L. Wong; Jonathan G. Crowston
Tags: bevacizumab, fibroblasts
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6524-6532. doi:https://doi.org/10.1167/iovs.10-5669
The Effect of Age on the Area of Complete Spatial Summation for Chromatic and Achromatic Stimuli Free
PDF
Tony Redmond; Margarita B. Zlatkova; David F. Garway-Heath; Roger S. Anderson
Tags: spatial summation
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6533-6539. doi:https://doi.org/10.1167/iovs.10-5717
Sensitivity Loss in Early Glaucoma Can Be Mapped to an Enlargement of the Area of Complete Spatial Summation Free
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Tony Redmond; David F. Garway-Heath; Margarita B. Zlatkova; Roger S. Anderson
Tags: glaucoma, hypertrophy, spatial summation
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6540-6548. doi:https://doi.org/10.1167/iovs.10-5718
Dichoptic Suppression of mfVEP Amplitude: Effect of Retinal Eccentricity and Simulated Unilateral Visual Impairment Free
PDF
John Leaney; Alexander Klistorner; Hemamalini Arvind; Stuart L. Graham
Tags: eye, visual impairment, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6549-6555. doi:https://doi.org/10.1167/iovs.10-5769

Immunology and Microbiology

GITR Ligand–Mediated Local Expansion of Regulatory T Cells and Immune Privilege of Corneal Allografts Free
PDF
Junko Hori; Hiroko Taniguchi; Mingcong Wang; Masamichi Oshima; Miyuki Azuma
Tags: allografting, cornea, regulatory t-lymphocytes, t-lymphocytes, ligands
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6556-6565. doi:https://doi.org/10.1167/iovs.09-4959
Two Different Regulatory T Cell Populations That Promote Corneal Allograft Survival Free
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Khrishen Cunnusamy; Kathryn Paunicka; Nancy Reyes; Wanhua Yang; Peter W. Chen; Jerry Y. Niederkorn
Tags: allografting, cornea, t-lymphocytes, mice
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6566-6574. doi:https://doi.org/10.1167/iovs.10-6161

Lens

7.1 T MRI to Assess the Anterior Segment of the Eye Free
PDF
Sönke Langner; Heiner Martin; Thom Terwee; Steven A. Koopmans; Paul C. Krüger; Norbert Hosten; Klaus-Peter Schmitz; Rudolf F. Guthoff; Oliver Stachs
Tags: eye, magnetic resonance imaging, diagnostic imaging, cercopithecidae, microbiology procedures
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6575-6581. doi:https://doi.org/10.1167/iovs.09-4865
Two Distinct Aquaporin 0s Required for Development and Transparency of the Zebrafish Lens Free
PDF
Alexandrine Froger; Daniel Clemens; Katalin Kalman; Karin L. Németh-Cahalan; Thomas F. Schilling; James E. Hall
Tags: lens (device), lens, crystalline, transparency, water, water channels
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6582-6592. doi:https://doi.org/10.1167/iovs.10-5626
The Relationship between Body and Ambient Temperature and Corneal Temperature Free
PDF
Line Kessel; Leif Johnson; Henrik Arvidsson; Michael Larsen
Tags: ambient temperature, body temperature, cornea, temperature
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6593-6597. doi:https://doi.org/10.1167/iovs.10-5659
Effect of Age on the Thioltransferase (Glutaredoxin) and Thioredoxin Systems in the Human Lens Free
PDF
Kui-Yi Xing; Marjorie F. Lou
Tags: lens (device), lens, crystalline, thioredoxin
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6598-6604. doi:https://doi.org/10.1167/iovs.10-5672

Low Vision

Driving with Hemianopia, II: Lane Position and Steering in a Driving Simulator Free
PDF
Alex R. Bowers; Aaron J. Mandel; Robert B. Goldstein; Eli Peli
Tags: driving simulators, hemianopsia, simulators, safety
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6605-6613. doi:https://doi.org/10.1167/iovs.10-5310

Multidisciplinary Ophthalmic Imaging

Evaluation of Contrast Agents for Enhanced Visualization in Optical Coherence Tomography Free
PDF
Justis P. Ehlers; Preeya K. Gupta; Sina Farsiu; Ramiro Maldonado; Terry Kim; Cynthia A. Toth; Prithvi Mruthyunjaya
Tags: contrast media, cornea, optical coherence tomography, wounds and injuries, diagnostic imaging
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6614-6619. doi:https://doi.org/10.1167/iovs.10-6195

Physiology and Pharmacology

Contact Lens Dynamometry: The Influence of Age Free
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Richard Stodtmeister; Tina Oppitz; Eberhard Spoerl; Michael Haustein; Andreas G. Boehm
Tags: contact lenses, diastole, ophthalmic artery, systole
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6620-6624. doi:https://doi.org/10.1167/iovs.09-4594
Genetic Inactivation of the Adenosine A2A Receptor Attenuates Pathologic but Not Developmental Angiogenesis in the Mouse Retina Free
PDF
Xiao-Ling Liu; Rong Zhou; Qi-Qi Pan; Xiao-Lin Jia; Wei-Na Gao; Jun Wu; Jing Lin; Jiang-Fan Chen
Tags: adenosine, angiogenesis, genetics, mice, neovascularization, pathologic
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6625-6632. doi:https://doi.org/10.1167/iovs.09-4900
Sphingosine-1-Phosphate Enhancement of Cortical Actomyosin Organization in Cultured Human Schlemm's Canal Endothelial Cell Monolayers Free
PDF
Grant M. Sumida; W. Daniel Stamer
Tags: actins, actomyosin, endothelial cells, rhoa gtp-binding protein, schlemm's canal
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6633-6638. doi:https://doi.org/10.1167/iovs.10-5391
In Glaucoma the Upregulated Truncated TrkC.T1 Receptor Isoform in Glia Causes Increased TNF-α Production, Leading to Retinal Ganglion Cell Death Free
PDF
Yujing Bai; ZhiHua Shi; Yehong Zhuo; Jing Liu; Andrey Malakhov; Eunhwa Ko; Kevin Burgess; Henry Schaefer; Pedro F. Esteban; Lino Tessarollo; H. Uri Saragovi
Tags: glaucoma, neurotrophic tyrosine kinase receptor type 3, tumor necrosis factors, mice
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6639-6651. doi:https://doi.org/10.1167/iovs.10-5431
Retrobulbar Blood Flow Velocities in Open Angle Glaucoma and Their Association with Mean Arterial Blood Pressure Free
PDF
Gerhard Garhöfer; Gabriele Fuchsjäger-Mayrl; Clemens Vass; Berthold Pemp; Anton Hommer; Leopold Schmetterer
Tags: arterial pressure, blood flow velocity, glaucoma, open-angle glaucoma, intraocular pressure
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6652-6657. doi:https://doi.org/10.1167/iovs.10-5490
In Vitro Screening for Angiostatic Potential of Herbal Chemicals Free
PDF
Liming Cao; Huanming Liu; Dennis Shun-Chiu Lam; Gary Hin-Fai Yam; Chi-Pui Pang
Tags: bevacizumab, endothelial cells, screening, vascular endothelial growth factor a, wounds and injuries
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6658-6664. doi:https://doi.org/10.1167/iovs.10-5524
Green Tea Polyphenols Attenuating Ultraviolet B–Induced Damage to Human Retinal Pigment Epithelial Cells In Vitro Free
PDF
Jing-Yi Xu; Liang-Yu Wu; Xin-Qiang Zheng; Jian-Liang Lu; Ming-Yan Wu; Yue-Rong Liang
Tags: retinal pigment cell, ultraviolet b radiation, survivin, green tea, polyphenols
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6665-6670. doi:https://doi.org/10.1167/iovs.10-5698
Beneficial Read-Through of a USH1C Nonsense Mutation by Designed Aminoglycoside NB30 in the Retina Free
PDF
Tobias Goldmann; Annie Rebibo-Sabbah; Nora Overlack; Igor Nudelman; Valery Belakhov; Timor Baasov; Tamar Ben-Yosef; Uwe Wolfrum; Kerstin Nagel-Wolfrum
Tags: aminoglycosides, mutation, nonsense, reading (activity), retina
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6671-6680. doi:https://doi.org/10.1167/iovs.10-5741
Novel Cellular Bouton Structure Activated by ATP in the Vascular Wall of Porcine Retinal Arterioles Free
PDF
Mikkel Wölck Misfeldt; Christian Aalkjær; Ulf Simonsen; Toke Bek
Tags: adenosine, arteriole, body tissue, calcium, presynaptic terminals
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6681-6687. doi:https://doi.org/10.1167/iovs.10-5753

Retina

α2-Adrenergic Receptors and Their Core Involvement in the Process of Axonal Growth in Retinal Explants Free
PDF
Verena Prokosch; Lambros Panagis; Gerd Fabian Volk; Caterina Dermon; Solon Thanos
Tags: glaucoma, replication origin, retina, surgical procedures, operative, proteins
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6688-6699. doi:https://doi.org/10.1167/iovs.09-4835
A Porcine Model of Selective Retinal Capillary Closure Induced by Embolization with Fluorescent Microspheres Free
PDF
Wallace S. Foulds; Wee K. Kek; Chi D. Luu; In Chin Song; Charanjit Kaur
Tags: blood capillaries, embolization, eye, microspheres, retina
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6700-6709. doi:https://doi.org/10.1167/iovs.09-4870
A Systematic Correlation between Morphology and Functional Alterations in Diabetic Macular Edema Free
PDF
Gábor György Deák; Matthias Bolz; Markus Ritter; Sonja Prager; Thomas Benesch; Ursula Schmidt-Erfurth; for the Diabetic Retinopathy Research Group Vienna
Tags: cysts, diabetic macular edema, language morphology, morphology, exudative retinal detachment
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6710-6714. doi:https://doi.org/10.1167/iovs.09-5064
Performance of Drusen Detection by Spectral-Domain Optical Coherence Tomography Free
PDF
Ferdinand G. Schlanitz; Christian Ahlers; Stefan Sacu; Christopher Schütze; Marcos Rodriguez; Sabine Schriefl; Isabelle Golbaz; Tobias Spalek; Geraldine Stock; Ursula Schmidt-Erfurth
Tags: drusen, optical coherence tomography
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6715-6721. doi:https://doi.org/10.1167/iovs.10-5288
A Central Dip in the Macular Pigment Spatial Profile Is Associated with Age and Smoking Free
PDF
Mark L. Kirby; Stephen Beatty; Edward Loane; Mukunda C. Akkali; Eithne E. Connolly; Jim Stack; John M. Nolan
Tags: pigment, risk factors, smoking, eye color, diet
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6722-6728. doi:https://doi.org/10.1167/iovs.10-5344
Impaired Retinal Circulation in Patients with Type 2 Diabetes Mellitus: Retinal Laser Doppler Velocimetry Study Free
PDF
Taiji Nagaoka; Eiichi Sato; Atsushi Takahashi; Harumasa Yokota; Kenji Sogawa; Akitoshi Yoshida
Tags: diabetes mellitus, type 2, retina circulation, velocimetry, laser-doppler, diabetic retinopathy
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6729-6734. doi:https://doi.org/10.1167/iovs.10-5364
Microstructure and Network Organization of the Microvasculature in the Human Macula Free
PDF
Paula K. Yu; Chandrakumar Balaratnasingam; Stephen J. Cringle; Ian L. McAllister; Jan Provis; Dao-Yi Yu
Tags: macula lutea, microvascular network, arteriole, blood capillaries, retina
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6735-6743. doi:https://doi.org/10.1167/iovs.10-5415
Retinal Function and Structure in Ant1-Deficient Mice Free
PDF
M. Joseph Phillips; Sarah Webb-Wood; Amanda E. Faulkner; Seema B. Jabbar; Valerie Biousse; Nancy J. Newman; Vi T. Do; Jeffrey H. Boatright; Douglas C. Wallace; Machelle T. Pardue
Tags: electroretinography, mice, retina
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6744-6752. doi:https://doi.org/10.1167/iovs.10-5421
Comparison of Multiple Stereoscopic and Monoscopic Digital Image Formats to Film for Diabetic Macular Edema Evaluation Free
PDF
Helen K. Li; Larry D. Hubbard; Ronald P. Danis; Jose F. Florez-Arango; Adol Esquivel; Elizabeth A. Krupinski
Tags: diabetic macular edema, eye, mosaicism, edema
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6753-6761. doi:https://doi.org/10.1167/iovs.10-5504
Temporal Response Properties of Retinal Ganglion Cells in rd1 Mice Evoked by Amplitude-Modulated Electrical Pulse Trains Free
PDF
Sang Baek Ryu; Jang Hee Ye; Yong Sook Goo; Chi Hyun Kim; Kyung Hwan Kim
Tags: mice, retina, retinal ganglion cells, rhythm, waveforms
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6762-6769. doi:https://doi.org/10.1167/iovs.10-5577
Defective Myogenic Response to Posture Change in Retinal Vessels of Well-Controlled Type 1 Diabetic Patients with No Retinopathy Free
PDF
Mara Lorenzi; Gilbert T. Feke; Linda Pitler; Fatmire Berisha; Julia Kolodjaschna; J. Wallace McMeel
Tags: diabetes mellitus, retinal diseases, retinal vessels, posture, diameter
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6770-6775. doi:https://doi.org/10.1167/iovs.10-5785
Decay Accelerating Factor (CD55)–Mediated Attenuation of Complement: Therapeutic Implications for Age-Related Macular Degeneration Free
PDF
Kelly N. Ma; Siobhan M. Cashman; J. Harry Sweigard; Rajendra Kumar-Singh
Tags: adenovirus infections, adenoviruses, age-related macular degeneration, antigens, cd55, complement membrane attack complex
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6776-6783. doi:https://doi.org/10.1167/iovs.10-5887

Retinal Cell Biology

Dynamic Patterns of Histone Lysine Methylation in the Developing Retina Free
PDF
Rajesh C. Rao; Kissaou T. Tchedre; Muhammad Taimur A. Malik; Natasha Coleman; Yuan Fang; Victor E. Marquez; Dong Feng Chen
Tags: ezh2 gene, histones, lysine, methylation, retina
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6784-6792. doi:https://doi.org/10.1167/iovs.09-4730
Altered Expression of Retinal Molecular Markers in the Canine RPE65 Model of Leber Congenital Amaurosis Free
PDF
Maria Hernández; Susan E. Pearce-Kelling; F. David Rodriguez; Gustavo D. Aguirre; Elena Vecino
Tags: antibodies, dog, domestic, leber's amaurosis, retina, retinal cone
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6793-6802. doi:https://doi.org/10.1167/iovs.10-5213
Role of c-Cbl–Dependent Regulation of Phospholipase Cγ1 Activation in Experimental Choroidal Neovascularization Free
PDF
Deeba Husain; Rosana D. Meyer; Manisha Mehta; Walther M. Pfeifer; Eva Chou; Gregory Navruzbekov; Ednan Ahmed; Nader Rahimi
Tags: angiogenesis, choroidal neovascularization, phospholipase, lasers, regulation
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6803-6809. doi:https://doi.org/10.1167/iovs.10-5255
GLUT-1 Expression in Bovine Retinal Capillary Endothelial Cells and Pericytes Exposed to Advanced Glycation End Products Free
PDF
Subramaniam Barathi; Narayanasamy Angayarkanni; Venil. N. Sumantran
Tags: cattle, endothelial cells, glut-1, glycosylation end products, advanced, pericytes
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6810-6814. doi:https://doi.org/10.1167/iovs.10-5312
Docosahexaenoic Acid Improves the Nitroso-Redox Balance and Reduces VEGF-Mediated Angiogenic Signaling in Microvascular Endothelial Cells Free
PDF
Nuria Matesanz; Grace Park; Hollie McAllister; William Leahey; Adrian Devine; Gary E. McVeigh; Tom A. Gardiner; Denise M. McDonald
Tags: angiogenesis, balance, device, docosahexaenoic acids, endothelial cells, equilibrium
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6815-6825. doi:https://doi.org/10.1167/iovs.10-5339

Visual Neuroscience

Incomplete Cortical Reorganization in Macular Degeneration Free
PDF
Tingting Liu; Sing-Hang Cheung; Ronald A. Schuchard; Christopher B. Glielmi; Xiaoping Hu; Sheng He; Gordon E. Legge
Tags: macular degeneration, functional magnetic resonance imaging, visual cortex
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6826-6834. doi:https://doi.org/10.1167/iovs.09-4926

Visual Psychophysics and Physiological Optics

Remaining Rod Activity Mediates Visual Behavior in Adult Rpe65 −/− mice. Free
PDF
Maité Cachafeiro; Alexis-Pierre Bemelmans; Kriss Canola; Vérène Pignat; Sylvain Vincent Crippa; Corinne Kostic; Yvan Arsenijevic
Tags: mice, rod photoreceptors, retinal cone, adult
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6835-6842. doi:https://doi.org/10.1167/iovs.09-3870
Pattern-Related Visual Stress, Chromaticity, and Accommodation Free
PDF
Peter M. Allen; Atif Hussain; Claire Usherwood; Arnold J. Wilkins
Tags: stress, visual accommodation, color
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6843-6849. doi:https://doi.org/10.1167/iovs.09-5086
Peripheral Ocular Aberrations in Mild and Moderate Keratoconus Free
PDF
David A. Atchison; Ankit Mathur; Scott A. Read; Mitchell I. Walker; Alexander R. Newman; Photios P. Tanos; Roderick T. McLennan; Andrew H. Tran
Tags: keratoconus, visual fields, coma
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6850-6857. doi:https://doi.org/10.1167/iovs.10-5188
Intersubject Variability of Foveal Cone Photoreceptor Density in Relation to Eye Length Free
PDF
Kaccie Y. Li; Pavan Tiruveedhula; Austin Roorda
Tags: eye, retinal cone
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6858-6867. doi:https://doi.org/10.1167/iovs.10-5499
Scene Perception in Age-Related Macular Degeneration Free
PDF
Thi Ha Chau Tran; Camille Rambaud; Pascal Despretz; Muriel Boucart
Tags: age-related macular degeneration, perception, gastrointestinal stromal tumor, peripheral vision, visual acuity
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6868-6874. doi:https://doi.org/10.1167/iovs.10-5517
Quantifying Sensory Eye Dominance in the Normal Visual System: A New Technique and Insights into Variation across Traditional Tests Free
PDF
Jingrong Li; Carly S. Y. Lam; Minbin Yu; Robert F. Hess; Lily Y. L. Chan; Goro Maehara; George C. Woo; Benjamin Thompson
Tags: eye, motion, ocular dominance, visual system
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6875-6881. doi:https://doi.org/10.1167/iovs.10-5549
In Vivo Analysis of Ciliary Muscle Morphologic Changes with Accommodation and Axial Ametropia Free
PDF
Amy L. Sheppard; Leon N. Davies
Tags: ciliary muscle, refractive errors, visual accommodation, eye
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6882-6889. doi:https://doi.org/10.1167/iovs.10-5787

Clinical Trials

The Effect of Bifocal Add on Accommodative Lag in Myopic Children with High Accommodative Lag Free
PDF
David A. Berntsen; Donald O. Mutti; Karla Zadnik
Tags: add-on code, child, visual accommodation, myopia
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6104-6110. doi:https://doi.org/10.1167/iovs.09-4417
Effects of Silicone Hydrogel Contact Lens Wear on Ocular Surface Sensitivity to Tactile, Pneumatic Mechanical, and Chemical Stimulation Free
PDF
Ping Situ; Trefford L. Simpson; Lyndon W. Jones; Desmond Fonn
Tags: conjunctiva, contact lenses, cornea, hydrogel, lens (device)
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6111-6117. doi:https://doi.org/10.1167/iovs.09-4807
Influence of Saffron Supplementation on Retinal Flicker Sensitivity in Early Age-Related Macular Degeneration Free
PDF
Benedetto Falsini; Marco Piccardi; Angelo Minnella; Cristina Savastano; Ettore Capoluongo; Antonello Fadda; Emilio Balestrazzi; Rita Maccarone; Silvia Bisti
Tags: age-related macular degeneration, photopsia, placebos, antioxidants, carotenoids
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6118-6124. doi:https://doi.org/10.1167/iovs.09-4995
An Objective Approach to Dry Eye Disease Severity Free
PDF
Benjamin D. Sullivan; Diane Whitmer; Kelly K. Nichols; Alan Tomlinson; Gary N. Foulks; Gerd Geerling; Jay S. Pepose; Valerie Kosheleff; Allison Porreco; Michael A. Lemp
Tags: dry eye syndromes, severity of illness
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6125-6130. doi:https://doi.org/10.1167/iovs.10-5390
Treatment of Geographic Atrophy by the Topical Administration of OT-551: Results of a Phase II Clinical Trial Free
PDF
Wai T. Wong; Waynekid Kam; Denise Cunningham; Molly Harrington; Keri Hammel; Catherine B. Meyerle; Catherine Cukras; Emily Y. Chew; Srinivas R. Sadda; Frederick L. Ferris
Tags: administration, topical, atrophy, eye, phase 2 clinical trials, visual acuity
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6131-6139. doi:https://doi.org/10.1167/iovs.10-5637
Long-term Evaluation of Refractive Status and Optical Components in Eyes of Children Born Prematurely Free
PDF
Ta-Ching Chen; Tzu-Hsun Tsai; Yung-Feng Shih; Po-Ting Yeh; Chang-Hao Yang; Fu-Chang Hu; Luke Long-Kuang Lin; Chung-May Yang
Tags: child, eye, infant, premature, myopia, optics
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6140-6148. doi:https://doi.org/10.1167/iovs.10-5234

Review

The Applications of Atomic Force Microscopy to Vision Science Free
PDF
Julie A. Last; Paul Russell; Paul F. Nealey; Christopher J. Murphy
Tags: cornea, diagnostic imaging, microscopy, atomic force, vision, tissue membrane
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6083-6094. doi:https://doi.org/10.1167/iovs.10-5470

Research Opportunities

Use of Patient-Reported Outcomes in Medical Product Development: A Report from the 2009 NEI/FDA Clinical Trial Endpoints Symposium Free
PDF
Rohit Varma; Elaine A. Richman; Frederick L. Ferris, III; Neil M. Bressler
Tags: glaucoma, patient self-report, surrogate endpoints, united states food and drug administration, ophthalmology
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6095-6103. doi:https://doi.org/10.1167/iovs.10-5627

Letters to the Editor

Effect of Ruboxistaurin on the Visual Acuity Decline Associated with Long-standing Diabetic Macular Edema Free
PDF
Atul Kumar Sahu; Ajit Babu Majji
Tags: diabetic macular edema, visual acuity
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6890. doi:https://doi.org/10.1167/iovs.09-4106
Author Response: Effect of Ruboxistaurin on the Visual Acuity Decline Associated with Long-standing Diabetic Macular Edema Free
PDF
Matthew J. Sheetz; Matthew D. Davis; Lloyd P. Aiello; Roy C. Milton; Ronald P. Danis; Xin Zhi; Aniz Girach; Maria C. Jimenez; Louis Vignati; for the PKC-DRS2 Study Group
Tags: diabetic macular edema, visual acuity
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6890-6891. doi:https://doi.org/10.1167/iovs.09-4285
Linear Relation between Structure and Function Free
PDF
Aharon Wegner; Alexander Erben
Tags: danish, nonarteritic anterior ischemic optic neuropathy, perimetry, retinal nerve fiber layer, anterior ischemic optic neuropathy
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6891. doi:https://doi.org/10.1167/iovs.09-4628
Author Response: Linear Relation between Structure and Function Free
PDF
Helen V. Danesh-Mayer; Michael V. Boland; Peter J. Savino; Neil R. Miller; Prem S. Subramanian; Christopher A. Girkin; Harry A. Quigley
Tags: anterior ischemic optic neuropathy, attention, diagnostic imaging, nonarteritic anterior ischemic optic neuropathy, open-angle glaucoma
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6891-6892. doi:https://doi.org/10.1167/iovs.10-5148
Tobacco Smoking and Its Impact on Corneal Biomechanics Free
PDF
Farhad Hafezi
Tags: biomechanics, cornea, smoking, tobacco
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6892. doi:https://doi.org/10.1167/iovs.09-4735
Lack of Statistical Power and Refractive Outcomes Free
PDF
Petros Aristodemou; Nathaniel Knox Cartwright; Robert Johnston
Tags: biometry, cataract surgery, precision, interferometry, ultrasonography
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6892-6893. doi:https://doi.org/10.1167/iovs.09-4983
Signal/Noise Ratios to Compare Tests for Measuring Visual Field Progression Free
PDF
Paul J. G. Ernest
Tags: noise, visual fields
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6893. doi:https://doi.org/10.1167/iovs.10-5442
Author Response: Signal/Noise Ratios to Compare Tests for Measuring Visual Field Progression Free
PDF
Paul H. Artes; Balwantray C. Chauhan
Tags: noise, visual fields
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6893-6894. doi:https://doi.org/10.1167/iovs.10-6417
“Metamorphopsia” Assessment Free
PDF
Marta Ugarte; Tom H. Williamson
Tags: metamorphopsias
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6894-6895. doi:https://doi.org/10.1167/iovs.10-5483
Author Response: “Metamorphopsia” Assessment Free
PDF
Kristian Krøyer; Ulrik Christensen; Morten la Cour; Michael Larsen
Tags: metamorphopsias
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6895. doi:https://doi.org/10.1167/iovs.10-5729
Metamorphopsia Assessment before and after Vitrectomy for Macular Hole Free
PDF
Vivek Dave; Raja Narayanan
Tags: macular holes, metamorphopsias, vitrectomy
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6895-6896. doi:https://doi.org/10.1167/iovs.10-5587
Author Response: Metamorphopsia Assessment before and after Vitrectomy for Macular Hole Free
PDF
Kristian Krøyer; Ulrik Christensen; Morten la Cour; Michael Larsen
Tags: macular holes, metamorphopsias, vitrectomy
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6896. doi:https://doi.org/10.1167/iovs.10-6082
Model-Fitting Adequacy and Clinical Rationality in Multivariate Linear Regression Analysis Free
PDF
Yi-Ting Hsieh
Tags: linear regression
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6896-6897. doi:https://doi.org/10.1167/iovs.10-5613
Author Response: Model-Fitting Adequacy and Clinical Rationality in Multivariate Linear Regression Analysis Free
PDF
Laurence Shen Lim; Tien Yin Wong
Tags: linear regression
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6897. doi:https://doi.org/10.1167/iovs.10-5894
Presbyopic Spectacles in Elderly Tanzanians Free
PDF
Celestin Habiyakare; Susan Lewallen; Paul Courtright
Tags: eyeglasses, older adult
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6897-6898. doi:https://doi.org/10.1167/iovs.10-5649
Amblyopia and Strabismus Questionnaire: Rasch Analysis Free
PDF
Elizabeth S. van de Graaf; Huibert J. Simonsz
Tags: amblyopia, questionnaires, rasch model, strabismus
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6898. doi:https://doi.org/10.1167/iovs.10-5761
Rasch Analysis for QoL Questionnaires Free
PDF
Henk Kelderman; Joost Felius; Jan Passchier
Tags: quality of life, questionnaires, rasch model
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6898-6899. doi:https://doi.org/10.1167/iovs.10-5762
Author Response: Amblyopia and Strabismus Questionnaire Free
PDF
Marta Vianya-Estopa; David B. Elliott; Brendan T. Barrett
Tags: amblyopia, questionnaires, strabismus
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6899-6900. doi:https://doi.org/10.1167/iovs.10-6176
GEN Is Not HGN Free
PDF
Karl Citek
Tags: gaze, pathologic nystagmus, gaze-evoked nystagmus
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6900-6901. doi:https://doi.org/10.1167/iovs.10-5889
Author Response: GEN Is Not HGN Free
PDF
Chad A. Whyte; Michael Rosenberg
Tags: gaze, pathologic nystagmus, gaze-evoked nystagmus
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6901. doi:https://doi.org/10.1167/iovs.10-6537
Eu-estrogenemia and Retinal Blood Flow Free
PDF
Ralph J. Turner; Irwin J. Kerber
Tags: vascular flow
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6901-6902. doi:https://doi.org/10.1167/iovs.10-5923
Author Response: Eu-estrogenemia and Retinal Blood Flow Free
PDF
Micheline C. Deschênes; Denise Descovich; Michèle Moreau; George A. Kuchel; Elvire Vaucher; Mark R. Lesk
Tags: vascular flow
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6902. doi:https://doi.org/10.1167/iovs.10-6451
Problems with Monotherapy for Bacterial Keratitis Free
PDF
James P. Guzek
Tags: bacterial keratitis
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6902-6903. doi:https://doi.org/10.1167/iovs.10-6000
Author Response: Problems with Monotherapy for Bacterial Keratitis Free
PDF
Stephen Kaye; Timothy Neal; Stephen Tuft; Christopher Parry
Tags: bacterial keratitis
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6903. doi:https://doi.org/10.1167/iovs.10-6148
The Effect of Bevacizumab on Human Tenon Fibroblasts in Ocular Wound Healing Free
PDF
Tine Van Bergen; Ingeborg Stalmans
Tags: bevacizumab, fibroblasts, wound healing
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6903-6904. doi:https://doi.org/10.1167/iovs.10-6116
Author Response: The Effect of Bevacizumab on Human Tenon Fibroblasts in Ocular Wound Healing Free
PDF
Evelyn O'Neill
Tags: bevacizumab, fibroblasts, wound healing
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6904. doi:https://doi.org/10.1167/iovs.10-6480
Genetic Testing and Clinical Characterization of Patients with Cone–Rod Dystrophy Free
PDF
Alberta A. H. J. Thiadens; Caroline C. W. Klaver
Tags: genetic screening, progressive cone-rod dystrophy, retinitis pigmentosa
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6904-6905. doi:https://doi.org/10.1167/iovs.10-6145
Author Response: Genetic Testing and Clinical Characterization of Patients with Cone–Rod Dystrophy Free
PDF
Karin W. Littink; Robert K. Koenekoop; L. Ingeborgh van den Born; Frans P. M. Cremers; Anneke I. den Hollander
Tags: genetic screening, retinitis pigmentosa
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6905. doi:https://doi.org/10.1167/iovs.10-6565
Effects of Fibroblastic and Endothelial Extracellular Matrices on Corneal Endothelial Cells Free
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Jules Baum
Tags: cornea, endothelial cells, endothelium, extracellular matrix
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6905-6906. doi:https://doi.org/10.1167/iovs.10-6230
Author Response: Effects of Fibroblastic and Endothelial Extracellular Matrices on Corneal Endothelial Cells Free
PDF
Rita Gruschwitz; Jens Friedrichs; Monika Valtink; Clemens Franz; Daniel J. Müller; Richard H. W. Funk; Katrin Engelmann
Tags: cornea, endothelial cells, endothelium, extracellular matrix
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6906. doi:https://doi.org/10.1167/iovs.10-6526
Bevacizumab Suppression of Establishment of Micrometastases in Experimental Ocular Melanoma Free
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Rajesh K. Sharma; Sankarathi Balaiya; Kakarla V. Chalam
Tags: bevacizumab, eye melanomas, micrometastasis
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6906. doi:https://doi.org/10.1167/iovs.10-6275
Author Response: Bevacizumab Suppression of Establishment of Micrometastases in Experimental Ocular Melanoma Free
PDF
Hua Yang; Martine J. Jager; Hans E. Grossniklaus
Tags: bevacizumab, eye melanomas, micrometastasis
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6906-6907. doi:https://doi.org/10.1167/iovs.10-6571
Passive Letter Subset Memory and Reliability of Visual Acuity Assessment Free
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Charles W. McMonnies
Tags: memory, reliability, visual acuity
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6907-6908. doi:https://doi.org/10.1167/iovs.10-6490
On the Presence and Role of Polar Lipids in Meibum Free
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Igor A. Butovich
Tags: lipids
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6908-6910. doi:https://doi.org/10.1167/iovs.10-6328
Author Response: On the Presence and Role of Polar Lipids in Meibum Free
PDF
Jianzhong Chen; Kari B. Green-Church; Kelly K. Nichols
Tags: lipids
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6910-6911. doi:https://doi.org/10.1167/iovs.10-6547

Erratum

Erratum Free
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Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6912. doi:https://doi.org/10.1167/iovs.09-3511a

Index

Thank You to Reviewers Free
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Tags: aloe, aries trial, basal energy expenditure, bees, betula
Investigative Ophthalmology & Visual Science December 2010, Vol.51, 6913-6919. doi:
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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