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Editorial

NEI Audacious Goals Initiative to Catalyze Innovation Free
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Paul A. Sieving
Tags: vision, vision research, eye, blindness, vision disorders
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7149-7150. doi:https://doi.org/10.1167/iovs.12-11069

Research Highlight

Existence of the Canonical Wnt Signaling Pathway in the Human Trabecular Meshwork Free
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Jose M. Gonzalez, Jr
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6972. doi:https://doi.org/10.1167/iovs.12-10985
Factors That Influence Automated Perimetry Free
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Murray Fingeret
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7018. doi:https://doi.org/10.1167/iovs.12-10966
Myopia Control with Corneal Reshaping Contact Lenses Free
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Jeffrey J. Walline
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7086. doi:https://doi.org/10.1167/iovs.12-10996
Unpicking the UPR Free
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Michael E. Cheetham
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7167. doi:https://doi.org/10.1167/iovs.12-11004
Toward the Optimum Measurement of Visual Acuity Free
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Tony Redmond
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7424. doi:https://doi.org/10.1167/iovs.12-11112

Anatomy and Pathology/Oncology

High Throughput Mass Spectrometry-Based Mutation Profiling of Primary Uveal Melanoma Free
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Anthony B. Daniels; Joo-Eun Lee; Laura E. MacConaill; Emanuele Palescandolo; Paul Van Hummelen; Scott M. Adams; Margaret M. DeAngelis; William C. Hahn; Evangelos S. Gragoudas; J. William Harbour; Levi A. Garraway; Ivana K. Kim
Tags: mutation, neoplasms, uveal melanoma, human monocytic ehrlichiosis, cancer
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6991-6996. doi:https://doi.org/10.1167/iovs.12-10427

Biochemistry and Molecular Biology

Phosphomimetic Mutants of Pigment Epithelium-Derived Factor with Enhanced Anti-Choroidal Melanoma Cell Activity In Vitro and In Vivo Free
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Ye Feng; Wenjing Bao; Yanli Luo; Ling Tian; Xiafang Chen; Miaoying Yi; Hui Xiong; Qian Huang
Tags: apoptosis, epithelium, melanoma, neoplasms, pigment
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6793-6802. doi:https://doi.org/10.1167/iovs.12-10326
Toward an Animal Model of the Human Tear Film: Biochemical Comparison of the Mouse, Canine, Rabbit, and Human Meibomian Lipidomes Free
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Igor A. Butovich; Hua Lu; Anne McMahon; J. Corinna Eule
Tags: animal model, dog, domestic, high pressure liquid chromatography procedure, lipids, mice
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6881-6896. doi:https://doi.org/10.1167/iovs.12-10516
Mass Spectrometric Analyses of Phosphatidylcholines in Alkali-Exposed Corneal Tissue Free
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Ashley M. Crane; Hong-Uyen Hua; Andrew D. Coggin; Bogdan G. Gugiu; Byron L. Lam; Sanjoy K. Bhattacharya
Tags: alkalies, body tissue, cornea, lecithin, lipids
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7122-7130. doi:https://doi.org/10.1167/iovs.12-10448
Diabetes Diminishes Phosphatidic Acid in the Retina: A Putative Mediator for Reduced mTOR Signaling and Increased Neuronal Cell Death Free
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Todd E. Fox; Megan M. Young; Michelle M. Pedersen; Xianlin Han; Thomas W. Gardner; Mark Kester
Tags: diabetes mellitus, insulin, mtor serine-threonine kinases, retina, signal transduction
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7257-7267. doi:https://doi.org/10.1167/iovs.11-7626
The Effects of Transforming Growth Factor-β2 on the Expression of Follistatin and Activin A in Normal and Glaucomatous Human Trabecular Meshwork Cells and Tissues Free
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Ashley M. Fitzgerald; Cecilia Benz; Abbot F. Clark; Robert J. Wordinger
Tags: activins, body tissue, follistatin, glaucoma, proteins
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7358-7369. doi:https://doi.org/10.1167/iovs.12-10292

Clinical and Epidemiologic Research

Validity, Reliability, and Repeatability of the Useful Field of View Test in Persons with Normal Vision and Patients with Glaucoma Free
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Sharon A. Bentley; Raymond P. LeBlanc; Marcelo T. Nicolela; Balwantray C. Chauhan
Tags: emmetropia, glaucoma, reliability, validity of results
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6763-6769. doi:https://doi.org/10.1167/iovs.12-9718
Central Corneal Thickness in a Korean Population: The Namil Study Free
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Young Hoon Hwang; Hwang Ki Kim; Yong Ho Sohn
Tags: cornea, glaucoma, hypertension, intraocular pressure, korean
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6851-6855. doi:https://doi.org/10.1167/iovs.12-10173
Comparison of LASIK and Surface Ablation by Using Propensity Score Analysis: A Multicenter Study in Korea Free
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Kyung-Sun Na; So-Hyang Chung; Jin Kook Kim; Eun Jin Jang; Na Rae Lee; Choun-Ki Joo
Tags: ablation, keratomileusis, laser in situ, korea, multicenter studies, surgical procedures, operative
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7116-7121. doi:https://doi.org/10.1167/iovs.12-9826
Time Outdoors, Visual Activity, and Myopia Progression in Juvenile-Onset Myopes Free
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Lisa A. Jones-Jordan; Loraine T. Sinnott; Susan A. Cotter; Robert N. Kleinstein; Ruth E. Manny; Donald O. Mutti; J. Daniel Twelker; Karla Zadnik,
Tags: child, myopia
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7169-7175. doi:https://doi.org/10.1167/iovs.11-8336
Impaired Mesopic Visual Acuity in Eyes with Early Age-Related Macular Degeneration Free
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María C. Puell; Ana R. Barrio; Catalina Palomo-Alvarez; Fernando J. Gómez-Sanz; Amaya Clement-Corral; María J. Pérez-Carrasco
Tags: age-related macular degeneration, eye, visual acuity, luminance
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7310-7314. doi:https://doi.org/10.1167/iovs.11-8649

Cornea

Gene Expression in Human Accessory Lacrimal Glands of Wolfring Free
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John L. Ubels; Ilene K. Gipson; Sandra J. Spurr-Michaud; Ann S. Tisdale; Rachel E. Van Dyken; Mark P. Hatton
Tags: bodily secretions, eyelid, gene expression, genes, lacrimal gland
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6738-6747. doi:https://doi.org/10.1167/iovs.12-10750
Effect of Histamine on Ca2+-Dependent Signaling Pathways in Rat Conjunctival Goblet Cells Free
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Dayu Li; Richard B. Carozza; Marie A. Shatos; Robin R. Hodges; Darlene A. Dartt
Tags: bodily secretions, conjunctiva, goblet cells, histamine, histamine receptors
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6928-6938. doi:https://doi.org/10.1167/iovs.12-10163
Gamma-Irradiation Reduces the Allogenicity of Donor Corneas Free
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William Stevenson; Sheng-Fu Cheng; Parisa Emami-Naeini; Jing Hua; Eleftherios I. Paschalis; Reza Dana; Daniel R. Saban
Tags: allografting, cornea, donors, tissue transplants, keratoplasty
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7151-7158. doi:https://doi.org/10.1167/iovs.12-9609
Loss of N-Cadherin from the Endothelium Causes Stromal Edema and Epithelial Dysgenesis in the Mouse Cornea Free
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Vassil S. Vassilev; Michiko Mandai; Shigenobu Yonemura; Masatoshi Takeichi
Tags: congenital abnormality, cornea, edema, endothelium, epithelium
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7183-7193. doi:https://doi.org/10.1167/iovs.12-9949
Lipid Component Contributions to the Surface Activity of Meibomian Lipids Free
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Burkhardt S. Schuett; Thomas J. Millar
Tags: lipids, esters
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7208-7219. doi:https://doi.org/10.1167/iovs.12-10471
NC1 Long and NC3 Short Splice Variants of Type XII Collagen Are Overexpressed during Corneal Scarring Free
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Dawiyat Massoudi; François Malecaze; Vincent Soler; Jacqueline Butterworth; Angélique Erraud; Pierre Fournié; Manuel Koch; Stéphane D. Galiacy
Tags: cicatrix, collagen type xii, cornea, mice, proteins
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7246-7256. doi:https://doi.org/10.1167/iovs.11-8592
Psychometric Properties of the NEI-RQL-42 Questionnaire in Keratoconus Free
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Colm McAlinden; Jyoti Khadka; Juliane de Freitas Santos Paranhos; Paulo Schor; Konrad Pesudovs
Tags: keratoconus, psychometrics, questionnaires, refractive errors
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7370-7374. doi:https://doi.org/10.1167/iovs.12-9969

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Extraocular Muscle Afferent Signals Modulate Visual Attention Free
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Daniela Balslev; William Newman; Paul C. Knox
Tags: afferent pathways, eye, muscle of orbit, proprioception, visual attention
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7004-7009. doi:https://doi.org/10.1167/iovs.12-10249
Binocular Eye Movement Control and Motion Perception: What Is Being Tracked? Free
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Johannes van der Steen; Joyce Dits
Tags: eye, eye movement, motion, motion perception, perception
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7268-7275. doi:https://doi.org/10.1167/iovs.12-9809
Functional Morphometry of Horizontal Rectus Extraocular Muscles during Horizontal Ocular Duction Free
PDF
Robert A. Clark; Joseph L. Demer
Tags: gaze, magnetic resonance imaging, muscle of orbit, volume, orbit
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7375-7379. doi:https://doi.org/10.1167/iovs.12-9730

Genetics

Genetic Characterization and Susceptibility for Sarcoidosis in Japanese Patients: Risk Factors of BTNL2 Gene Polymorphisms and HLA Class II Alleles Free
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Hitomi Suzuki; Masao Ota; Akira Meguro; Yoshihiko Katsuyama; Tatukata Kawagoe; Mami Ishihara; Yuri Asukata; Masaki Takeuchi; Norihiko Ito; Etsuko Shibuya; Eiichi Nomura; Riyo Uemoto; Tadayuki Nishide; Kenichi Namba; Nobuyoshi Kitaichi; Shin-ichiro Morimoto; Toshikatsu Kaburaki; Yasutaka Ando; Shinobu Takenaka; Jutaro Nakamura; Kozou Saeki; Shigeaki Ohno; Hidetoshi Inoko; Nobuhisa Mizuki
Tags: alleles, disease susceptibility, genes, genetics, human leukocyte antigens
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7109-7115. doi:https://doi.org/10.1167/iovs.12-10491
Genetic Variants near PDGFRA Are Associated with Corneal Curvature in Australians Free
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Aniket Mishra; Seyhan Yazar; Alex W. Hewitt; Jenny A. Mountain; Wei Ang; Craig E. Pennell; Nicholas G. Martin; Grant W. Montgomery; Christopher J. Hammond; Terri L. Young; Stuart Macgregor; David A. Mackey
Tags: chief complaint, cornea, genetics, platelet-derived growth factor alpha receptor, single nucleotide polymorphism
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7131-7136. doi:https://doi.org/10.1167/iovs.12-10489

Glaucoma

In Vivo Analysis of Vectors Involved in Pupil Constriction in Chinese Subjects with Angle Closure Free
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Ce Zheng; Carol Y. Cheung; Tin Aung; Arun Narayanaswamy; Sim-Heng Ong; David S. Friedman; John C. Allen; Mani Baskaran; Paul T. Chew; Shamira A. Perera
Tags: chinese (other dialects), chinese people, eye, immune reconstitution inflammatory syndrome, iris
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6756-6762. doi:https://doi.org/10.1167/iovs.12-10415
Visual Field Progression in Glaucoma: Estimating the Overall Significance of Deterioration with Permutation Analyses of Pointwise Linear Regression (PoPLR) Free
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Neil O'Leary; Balwantray C. Chauhan; Paul H. Artes
Tags: glaucoma, linear regression, visual fields, false-positive results, significance
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6776-6784. doi:https://doi.org/10.1167/iovs.12-10049
Human Lamina Cribrosa Insertion and Age Free
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Ian A. Sigal; John G. Flanagan; Kira L. Lathrop; Inka Tertinegg; Richard Bilonick
Tags: body tissue, cribriform plate, donors, eye, optic disk
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6870-6879. doi:https://doi.org/10.1167/iovs.12-9890
A Novel Aptamer Targeting TGF-β Receptor II Inhibits Transdifferentiation of Human Tenon's Fibroblasts into Myofibroblast Free
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Xiaoyan Zhu; Lei Li; Lingyun Zou; Xudong Zhu; Guangjun Xian; Haijun Li; Yan Tan; Lin Xie
Tags: cell transdifferentiation, fibroblasts, gel, myofibroblasts, proteins
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6897-6903. doi:https://doi.org/10.1167/iovs.12-10198
A Novel Method to Detect Local Ganglion Cell Loss in Early Glaucoma Using Spectral-Domain Optical Coherence Tomography Free
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Kohei Takayama; Masanori Hangai; Mary Durbin; Noriko Nakano; Satoshi Morooka; Tadamichi Akagi; Hanako Ohashi Ikeda; Nagahisa Yoshimura
Tags: eye, ganglia, glaucoma, optical coherence tomography
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6904-6913. doi:https://doi.org/10.1167/iovs.12-10210
A Model to Measure Fluid Outflow in Rabbit Capsules Post Glaucoma Implant Surgery Free
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Dan Q. Nguyen; Craig M. Ross; Yu Qin Li; Surinder Pandav; Bruce Gardiner; David Smith; Alicia C. How; Jonathan G. Crowston; Michael A. Coote
Tags: glaucoma, implants, oryctolagus cuniculus, surgical procedures, operative, eye
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6914-6919. doi:https://doi.org/10.1167/iovs.12-10438
The Structure and Function Relationship in Glaucoma: Implications for Detection of Progression and Measurement of Rates of Change Free
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Felipe A. Medeiros; Linda M. Zangwill; Christopher Bowd; Kaweh Mansouri; Robert N. Weinreb
Tags: glaucoma, retinal nerve fiber layer, eye
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6939-6946. doi:https://doi.org/10.1167/iovs.12-10345
An Anatomically Customizable Computational Model Relating the Visual Field to the Optic Nerve Head in Individual Eyes Free
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Jonathan Denniss; Allison M. McKendrick; Andrew Turpin
Tags: computer simulation, eye, optic disk, visual fields, maps
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6981-6990. doi:https://doi.org/10.1167/iovs.12-9657
Factors That Influence Standard Automated Perimetry Test Results in Glaucoma: Test Reliability, Technician Experience, Time of Day, and Season Free
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Francisco G. Junoy Montolio; Christiaan Wesselink; Marijke Gordijn; Nomdo M. Jansonius
Tags: glaucoma, glaucoma screening, laboratory test finding, perimetry, reliability
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7010-7017. doi:https://doi.org/10.1167/iovs.12-10268
Existence of the Canonical Wnt Signaling Pathway in the Human Trabecular Meshwork Free
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Weiming Mao; J. Cameron Millar; Wan-Heng Wang; Sean M. Silverman; Yang Liu; Robert J. Wordinger; Jeffrey S. Rubin; Iok-Hou Pang; Abbot F. Clark
Tags: trabecular meshwork, wnt signaling pathway, intraocular pressure, luciferases, signal transduction
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7043-7051. doi:https://doi.org/10.1167/iovs.12-9664
Involvement of RhoA/Rho-Associated Kinase Signal Transduction Pathway in Dexamethasone-Induced Alterations in Aqueous Outflow Free
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Tomokazu Fujimoto; Toshihiro Inoue; Takanori Kameda; Nanako Kasaoka; Miyuki Inoue-Mochita; Naoko Tsuboi; Hidenobu Tanihara
Tags: dexamethasone, mechlorethamine, phosphotransferases, rhoa gtp-binding protein, signal transduction
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7097-7108. doi:https://doi.org/10.1167/iovs.12-9989
Endogenous Production of Extracellular Adenosine by Trabecular Meshwork Cells: Potential Role in Outflow Regulation Free
PDF
Jing Wu; Guorong Li; Coralia Luna; Ivan Spasojevic; David L. Epstein; Pedro Gonzalez
Tags: adenosine, regulation
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7142-7148. doi:https://doi.org/10.1167/iovs.12-9968
Retinal Nerve Fiber Layer Imaging with Spectral-Domain Optical Coherence Tomography: Interpreting the RNFL Maps in Healthy Myopic Eyes Free
PDF
Christopher Kai-Shun Leung; Marco Yu; Robert N. Weinreb; Heather Kayew Mak; Gilda Lai; Cong Ye; Dennis Shun-Chiu Lam
Tags: diagnostic imaging, eye, retinal nerve fiber layer, optical coherence tomography, maps
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7194-7200. doi:https://doi.org/10.1167/iovs.12-9726
Dynamic Changes in Anterior Segment Morphology during the Valsalva Maneuver Assessed with Ultrasound Biomicroscopy Free
PDF
Bing-Song Wang; Lin Xiao; Jing Liu; Ning Dong; Tin Aung
Tags: language morphology, morphology, ultrasound biomicroscopy, valsalva maneuver
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7286-7289. doi:https://doi.org/10.1167/iovs.12-10497
Dorsomedial/Perifornical Hypothalamic Stimulation Increases Intraocular Pressure, Intracranial Pressure, and the Translaminar Pressure Gradient Free
PDF
Brian C. Samuels; Nathan M. Hammes; Philip L. Johnson; Anantha Shekhar; Stuart J. McKinnon; R. Rand Allingham
Tags: hypothalamus, intracranial pressure, intraocular pressure, pefloxacin, peak expiratory flow rate measurement
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7328-7335. doi:https://doi.org/10.1167/iovs.12-10632
Correlation of Endothelin-1 Concentration in Aqueous Humor with Intraocular Pressure in Primary Open Angle and Pseudoexfoliation Glaucoma Free
PDF
Lars Choritz; Maren Machert; Hagen Thieme
Tags: aqueous humor, endothelin-1, intraocular pressure, mass or substance concentration per volume, exfoliation syndrome
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7336-7342. doi:https://doi.org/10.1167/iovs.12-10216
The Shape of the Ganglion Cell plus Inner Plexiform Layers of the Normal Human Macula Free
PDF
Robert W. Knighton; Giovanni Gregori
Tags: eye, fovea centralis, ganglia, macula densa, macula lutea
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7412-7420. doi:https://doi.org/10.1167/iovs.12-10515

Immunology and Microbiology

Cytokines and Chemokines in the Vitreous Fluid of Eyes with Uveal Melanoma Free
PDF
Nisha Nagarkatti-Gude; Inge H. G. Bronkhorst; Sjoerd G. van Duinen; Gregorius P. M. Luyten; Martine J. Jager
Tags: chemokines, cytokine, eye, neoplasms, uveal melanoma
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6748-6755. doi:https://doi.org/10.1167/iovs.12-10123
CXCL1-Deficient Mice Are Highly Sensitive to Pseudomonas aeruginosa but Not Herpes Simplex Virus Type 1 Corneal Infection Free
PDF
Katie M. Bryant-Hudson; Daniel J. J. Carr
Tags: chemokine (c-x-c motif) ligand 1, cornea, corneal infections, human herpesvirus 1, infections
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6785-6792. doi:https://doi.org/10.1167/iovs.12-10400
Migration of Toxoplasma gondii –Infected Dendritic Cells across Human Retinal Vascular Endothelium Free
PDF
João M. Furtado; Arpita S. Bharadwaj; Liam M. Ashander; Antoinette Olivas; Justine R. Smith
Tags: dendritic cells, endothelium, vascular endothelium, toxoplasma gondii, antibodies
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6856-6862. doi:https://doi.org/10.1167/iovs.12-10384
Visual Functional and Histopathological Correlation in Experimental Autoimmune Optic Neuritis Free
PDF
Yoshimichi Matsunaga; Takeshi Kezuka; Xiaoming An; Kouji Fujita; Nagahisa Matsuyama; Ryusaku Matsuda; Yoshihiko Usui; Naoyuki Yamakawa; Masahiko Kuroda; Hiroshi Goto
Tags: autoimmunity, demyelination, evoked potentials, visual, histopathology tests, mice
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6964-6971. doi:https://doi.org/10.1167/iovs.12-10559
Interleukin-10 Gene-Transfected Mature Dendritic Cells Suppress Murine Experimental Autoimmune Optic Neuritis Free
PDF
Ryusaku Matsuda; Takeshi Kezuka; Chiharu Nishiyama; Yoshihiko Usui; Yoshimichi Matsunaga; Yoko Okunuki; Naoyuki Yamakawa; Hideoki Ogawa; Ko Okumura; Hiroshi Goto
Tags: interleukin-10, mdc protocol, mice, immunization, autoimmune diseases
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7235-7245. doi:https://doi.org/10.1167/iovs.12-10587
Immunosuppressive Properties of Regulatory T Cells Generated by Incubation of Peripheral Blood Mononuclear Cells with Supernatants of Human RPE Cells Free
PDF
Ayano Imai; Sunao Sugita; Yuko Kawazoe; Shintaro Horie; Yukiko Yamada; Hiroshi Keino; Kazuichi Maruyama; Manabu Mochizuki
Tags: antibodies, antigens, cd25, cytokine, foxp3 gene, immunosuppressive agents
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7299-7309. doi:https://doi.org/10.1167/iovs.12-10182
Innate Immune Regulation of Serratia marcescens –Induced Corneal Inflammation and Infection Free
PDF
Rong Zhou; Rui Zhang; Yan Sun; Sean Platt; Loretta Szczotka-Flynn; Eric Pearlman
Tags: cornea, infections, keratitis, mice, toll-like receptor 4
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7382-7388. doi:https://doi.org/10.1167/iovs.12-10238

Lens

Fluid Circulation Determined in the Isolated Bovine Lens Free
PDF
Oscar A. Candia; Richard Mathias; Rosana Gerometta
Tags: cattle, lens (device), lens, crystalline, bathing
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7087-7096. doi:https://doi.org/10.1167/iovs.12-10295
Ultraviolet Radiation–Induced Cataract in Mice: The Effect of Age and the Potential Biochemical Mechanism Free
PDF
Jie Zhang; Hong Yan; Stefan Löfgren; Xiaoli Tian; Marjorie F. Lou
Tags: lens (device), lens, crystalline, mice, ultraviolet rays, proteins
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7276-7285. doi:https://doi.org/10.1167/iovs.12-10482

Low Vision

Adjustment to Vision Loss in a Mixed Sample of Adults with Established Visual Impairment Free
PDF
Daryl R. Tabrett; Keziah Latham
Tags: blindness, visual impairment, adult, depressive disorders, self-report
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7227-7234. doi:https://doi.org/10.1167/iovs.12-10404

Multidisciplinary Ophthalmic Imaging

Stimulus-Specific Pupil Dynamics Measured in Birds (Gallus gallus domesticus) In Vivo with Ultrahigh Resolution Optical Coherence Tomography Free
PDF
Alireza Akhlagh Moayed; Vivian Choh; Sepideh Hariri; Chenyi Liu; Alexander Wong; Kostadinka Bizheva
Tags: aves, chickens, diagnostic imaging, optical coherence tomography, pupil
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6863-6869. doi:https://doi.org/10.1167/iovs.12-10291
An Approach to Measure Blood Flow in Single Choroidal Vessel Using Doppler Optical Coherence Tomography Free
PDF
Masahiro Miura; Shuichi Makita; Takuya Iwasaki; Yoshiaki Yasuno
Tags: optical coherence tomography, vascular flow
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7137-7141. doi:https://doi.org/10.1167/iovs.12-10666
Assessment of Retinal Morphology with Spectral and Time Domain OCT in the Phase III Trials of Enzymatic Vitreolysis Free
PDF
Francisco A. Folgar; Cynthia A. Toth; Francis Char DeCroos; Aniz Girach; Steve Pakola; Glenn J. Jaffe
Tags: eye, language morphology, morphology, ocriplasmin, phase 3 clinical trials
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7395-7401. doi:https://doi.org/10.1167/iovs.12-10379

Nantotechnology and Regenerative Medicine

EphA2 Targeted Doxorubicin Stealth Liposomes as a Therapy System for Choroidal Neovascularization in Rats Free
PDF
Jia-lin Wang; Yu-ling Liu; Ying Li; Wen-bing Dai; Zhao-ming Guo; Zhao-hui Wang; Qiang Zhang
Tags: choroidal neovascularization, liposomes, doxorubicin, rats
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7348-7357. doi:https://doi.org/10.1167/iovs.12-9955

Physiology and Pharmacology

Menthol Activation of Corneal Cool Cells Induces TRPM8-Mediated Lacrimation but Not Nociceptive Responses in Rodents Free
PDF
Ashlee Robbins; Masayuki Kurose; Barbara J. Winterson; Ian D. Meng
Tags: cornea, menthol, tear production, rodentia
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7034-7042. doi:https://doi.org/10.1167/iovs.12-10025

Retina

Associations between Metamorphopsia and Foveal Microstructure in Patients with Epiretinal Membrane Free
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Fumiki Okamoto; Yoshimi Sugiura; Yoshifumi Okamoto; Takahiro Hiraoka; Tetsuro Oshika
Tags: epiretinal membrane, metamorphopsias
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6770-6775. doi:https://doi.org/10.1167/iovs.12-9683
Choroidal Thinning in Diabetes Type 1 Detected by 3-Dimensional 1060 nm Optical Coherence Tomography Free
PDF
Marieh Esmaeelpour; Simon Brunner; Siamak Ansari-Shahrezaei; Susanne Nemetz; Boris Považay; Vedran Kajic; Wolfgang Drexler; Susanne Binder
Tags: diabetes mellitus, diabetes mellitus, type 1, eye, maps, optical coherence tomography
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6803-6809. doi:https://doi.org/10.1167/iovs.12-10314
Evaluation of Ultrasound-Assisted Thrombolysis Using Custom Liposomes in a Model of Retinal Vein Occlusion Free
PDF
Walid F. Abdallah; Hitenkumar Patel; Edward G. Grant; Bruno Diniz; Gerald J. Chader; Mark S. Humayun
Tags: liposomes, retinal vein occlusion, thrombolytic therapy, ultrasonography, lasers
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6920-6927. doi:https://doi.org/10.1167/iovs.12-10389
The Retinal Clock Drives the Expression of Kcnv2, a Channel Essential for Visual Function and Cone Survival Free
PDF
Philip Hölter; Stefanie Kunst; Tanja Wolloscheck; Debra K. Kelleher; Carsten Sticht; Uwe Wolfrum; Rainer Spessert
Tags: genes, photoreceptors, regulation, retina, retinal cone
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6947-6954. doi:https://doi.org/10.1167/iovs.12-10234
Epithelial-Mesenchymal Transition-Like Phenotypic Changes of Retinal Pigment Epithelium Induced by TGF-β Are Prevented by PPAR-γ Agonists Free
PDF
Hiroki Hatanaka; Noriko Koizumi; Naoki Okumura; EunDuck P. Kay; Eri Mizuhara; Junji Hamuro; Shigeru Kinoshita
Tags: agonists, peroxisome proliferator-activated receptors, phenotype, epithelium, retinal pigment epithelium
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6955-6963. doi:https://doi.org/10.1167/iovs.12-10488
Antiangiogenic Shift in Vitreous after Vitrectomy in Patients with Proliferative Diabetic Retinopathy Free
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Shigeo Yoshida; Takahito Nakama; Keijiro Ishikawa; Mitsuru Arima; Takashi Tachibana; Shintaro Nakao; Yukio Sassa; Miho Yasuda; Hiroshi Enaida; Yuji Oshima; Toshihiro Kono; Tatsuro Ishibashi
Tags: angiogenesis inhibitors, proliferative diabetic retinopathy, vascular endothelial growth factor a, vitrectomy, vitreous body
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6997-7003. doi:https://doi.org/10.1167/iovs.12-9671
Photoreceptor Layer Regeneration is Detectable in the Human Retina Imaged by SD-OCT after Laser Treatment Using Subthreshold Laser Power Free
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Gábor György Deák; Matthias Bolz; Sonja Prager; Markus Ritter; Katharina Kriechbaum; Christoph Scholda; Ursula Schmidt-Erfurth; the Diabetic Retinopathy Research Group Vienna
Tags: laser therapy, lasers, photoreceptors, retina, burns
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7019-7025. doi:https://doi.org/10.1167/iovs.12-10196
Single Nucleotide Polymorphism in the Cholesterol-24S-Hydroxylase (CYP46A1) Gene and Its Association with CFH and LOC387715 Gene Polymorphisms in Age-Related Macular Degeneration Free
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Cynthia Fourgeux; Brice Dugas; Florence Richard; Ingemar Björkhem; Niyazi Acar; Alain M. Bron; Jean-François Korobelnik; Nicolas Leveziel; Jennyfer Zerbib; Nathalie Puche; Catherine P. Creuzot-Garcher; Eric Souied; Lionel Bretillon
Tags: age-related macular degeneration, cholesterol, genes, hydroxycholesterols, mixed function oxygenases
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7026-7033. doi:https://doi.org/10.1167/iovs.12-9652
Association between Local Neuroretinal Function and Control of Adolescent Type 1 Diabetes Free
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Michal Laron; Marcus A. Bearse, Jr; Kevin Bronson-Castain; Soffia Jonasdottir; Barbara King-Hooper; Shirin Barez; Marilyn E. Schneck; Anthony J. Adams
Tags: adolescent, diabetes mellitus, diabetes mellitus, type 1, diabetes mellitus, type 2, retinal diseases
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7071-7076. doi:https://doi.org/10.1167/iovs.12-10570
Analysis of Spectral-Domain Optical Coherence Tomography in Preterm Children: Retinal Layer Thickness and Choroidal Thickness Profiles Free
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Kyung-Ah Park; Sei Yeul Oh
Tags: child, infant, premature, optical coherence tomography, premature birth
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7201-7207. doi:https://doi.org/10.1167/iovs.12-10599
Neuroretinal Cell Death in a Murine Model of Closed Globe Injury: Pathological and Functional Characterization Free
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Richard J. Blanch; Zubair Ahmed; Attila Sik; David R. J. Snead; Peter A. Good; Jenna O'Neill; Martin Berry; Robert A. H. Scott; Ann Logan
Tags: eye, wounds and injuries, photoreceptors, cell death
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7220-7226. doi:https://doi.org/10.1167/iovs.12-9887
Observations of Vascular Structures within and Posterior to Sclera in Eyes with Pathologic Myopia by Swept-Source Optical Coherence Tomography Free
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Kyoko Ohno-Matsui; Masahiro Akiba; Tatsuro Ishibashi; Muka Moriyama
Tags: eye, myopic macular degeneration, optical coherence tomography, sclera, choroid
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7290-7298. doi:https://doi.org/10.1167/iovs.12-10371
Topographic Changes of Retinal Layers after Resolution of Acute Retinal Detachment Free
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Jae Hui Kim; Do Young Park; Hyo Shin Ha; Se Woong Kang
Tags: retinal detachment, eye, surgical procedures, operative, retina
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7316-7321. doi:https://doi.org/10.1167/iovs.12-10155
Influence of the Interposition of a Nonhollow Probe during Cannula Extraction on Sclerotomy Vitreous Incarceration in Sutureless Vitrectomy Free
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Javier Benitez-Herreros; Lorenzo Lopez-Guajardo; Cristina Camara-Gonzalez; Agustin Silva-Mato
Tags: sclerotomy, vitrectomy, vitreous body, entrapment (morphologic abnormality)
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7322-7326. doi:https://doi.org/10.1167/iovs.12-10274

Retinal Cell Biology

Heparanase and Vascular Endothelial Growth Factor Expression Is Increased in Hypoxia-Induced Retinal Neovascularization Free
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Jie Hu; Xin Song; Yi Qing He; Craig Freeman; Christopher R. Parish; Ling Yuan; Honghua Yu; Shibo Tang
Tags: hypoxia, retinal neovascularization, vascular endothelial growth factor a, retina, mice
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6810-6817. doi:https://doi.org/10.1167/iovs.11-9144
eNOS Overexpression Exacerbates Vascular Closure in the Obliterative Phase of OIR and Increases Angiogenic Drive in the Subsequent Proliferative Stage Free
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Kevin Edgar; Thomas A. Gardiner; Rien van Haperen; Rini de Crom; Denise M. McDonald
Tags: nitric oxide synthase, protein overexpression, retina, ischemia, angiogenesis
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6833-6850. doi:https://doi.org/10.1167/iovs.12-9797
Selective Activation of ATF6 and PERK Endoplasmic Reticulum Stress Signaling Pathways Prevent Mutant Rhodopsin Accumulation Free
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Wei-Chieh Chiang; Nobuhiko Hiramatsu; Carissa Messah; Heike Kroeger; Jonathan H. Lin
Tags: proteins, rhodopsin, stress, signal pathway, signal transduction pathways
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7159-7166. doi:https://doi.org/10.1167/iovs.12-10222
Phototoxicity of Indocyanine Green and Brilliant Blue G under Continuous Fluorescent Illumination on Cultured Human Retinal Pigment Epithelial Cells Free
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Kei Takayama; Tomohito Sato; Yoko Karasawa; Shunichi Sato; Masataka Ito; Masaru Takeuchi
Tags: brilliant blue g, dyes, indocyanine green, light, lighting
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7389-7394. doi:https://doi.org/10.1167/iovs.12-10754
Mitochondrial Dynamics Regulate Growth Cone Motility, Guidance, and Neurite Growth Rate in Perinatal Retinal Ganglion Cells In Vitro Free
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Michael B. Steketee; Stavros N. Moysidis; Jessica E. Weinstein; Alex Kreymerman; Jose P. Silva; Siraj Iqbal; Jeffrey L. Goldberg
Tags: cell motility, growth cones, mitochondria, neural development, neurites
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7402-7411. doi:https://doi.org/10.1167/iovs.12-10298

Visual Neuroscience

Macular Function in Eyes with Open-Angle Glaucoma Evaluated by Multifocal Electroretinogram Free
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Vincenzo Parisi; Lucia Ziccardi; Marco Centofanti; Lucia Tanga; Geltrude Gallinaro; Benedetto Falsini; Massimo G. Bucci
Tags: electroretinography, eye, macular function, open-angle glaucoma, reactive airways dysfunction syndrome
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6973-6980. doi:https://doi.org/10.1167/iovs.12-10256
Retinal Function and Morphology in Monkeys with Ethambutol-Induced Optic Neuropathy Free
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Junzo Kinoshita; Noriaki Iwata; Takanori Maejima; Tomofumi Kimotsuki; Mitsuya Yasuda
Tags: cercopithecidae, ethambutol, optic nerve disorders, retina, electroretinography
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7052-7062. doi:https://doi.org/10.1167/iovs.12-10308
Pupillometric Evaluation of the Dynamics of the Pupillary Response to a Brief Light Stimulus in Healthy Subjects Free
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Fion D. Bremner
Tags: constriction procedure, pupil, pupil reaction, velocity, pupil size
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7343-7347. doi:https://doi.org/10.1167/iovs.12-10881

Visual Psychophysics and Physiological Optics

Does Partial Occlusion Promote Normal Binocular Function? Free
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Jingrong Li; Benjamin Thompson; Zhaofeng Ding; Lily Y. L. Chan; Xiang Chen; Minbin Yu; Daming Deng; Robert F. Hess
Tags: filters, vision, depth perception, optics, amblyopia
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6818-6827. doi:https://doi.org/10.1167/iovs.12-10390
Effect of Optical Defocus on Detection and Recognition of Vanishing Optotype Letters in the Fovea and Periphery Free
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Nilpa Shah; Steven C. Dakin; Roger S. Anderson
Tags: fovea centralis, optics
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7063-7070. doi:https://doi.org/10.1167/iovs.12-9864
Sign-Dependent Sensitivity to Peripheral Defocus for Myopes due to Aberrations Free
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Robert Rosén; Linda Lundström; Peter Unsbo
Tags: eye, psychophysics, optics, coma, astigmatism
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7176-7182. doi:https://doi.org/10.1167/iovs.11-9034

Clinical Trials

Retardation of Myopia in Orthokeratology (ROMIO) Study: A 2-Year Randomized Clinical Trial Free
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Pauline Cho; Sin-Wan Cheung
Tags: clinical trials, myopia, orthokeratology
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7077-7085. doi:https://doi.org/10.1167/iovs.12-10565

Letters to the Editor

In Vivo Oxygen Uptake into the Human Cornea Free
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Barbara A. Fink; Richard M. Hill
Tags: cornea, oxygen
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6828. doi:https://doi.org/10.1167/iovs.12-10692
Author Response: In Vivo Oxygen Uptake into the Human Cornea Free
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Sho C. Takatori; Percy Lazon de la Jara; Brien Holden; Klaus Ehrmann; Arthur Ho; Clayton J. Radke
Tags: cornea, oxygen
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6829. doi:https://doi.org/10.1167/iovs.12-10901
The Coefficient of Determination: What Determines a Useful R 2 Statistic? Free
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Luke J. Saunders; Richard A. Russell; David P. Crabb
Tags: coefficient of determination
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6830-6832. doi:https://doi.org/10.1167/iovs.12-10598
Author Response: Retinal Vein Pulsation Is in Phase with Intracranial Pressure and Not Intraocular Pressure Free
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William H. Morgan; Christopher R. P. Lind; Samuel Kain; Naeem Fatehee; Arul Bala; Dao-Yi Yu
Tags: central retinal vein, intracranial pressure, intraocular pressure
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 6880. doi:https://doi.org/10.1167/iovs.12-10943
Spectral-Domain Optical Coherence Tomography as a Noninvasive Method to Assess Damaged and Regenerating Adult Zebrafish Retinas Free
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Joel S Schuman; Larry Kagemann; Hiroshi Ishikawa; Gadi Wollstein
Tags: adult, optical coherence tomography, retina, zebrafish
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7315. doi:https://doi.org/10.1167/iovs.12-10925
Different Efficacy of Propranolol in Mice with Oxygen-Induced Retinopathy: Could Differential Effects of Propranolol Be Related to Differences in Mouse Strains? Free
PDF
Luca Filippi; Massimo Dal Monte; Paola Bagnoli
Tags: mice, oxygen, propranolol, retinal diseases
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7421-7423. doi:https://doi.org/10.1167/iovs.12-10721
Axial Length Probably Does Not Change with Shift in Gaze Free
PDF
Ronald A. Schachar; Norman S. Levy
Tags: gaze
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7425. doi:https://doi.org/10.1167/iovs.12-11086

Erratum

Erratum Free
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Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7168. doi:https://doi.org/10.1167/iovs.11-9054a
Erratum Free
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Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7327. doi:https://doi.org/10.1167/iovs.11-7541a
Erratum Free
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Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7380. doi:https://doi.org/10.1167/iovs.12-10163a
Erratum Free
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Investigative Ophthalmology & Visual Science October 2012, Vol.53, 7381. doi:https://doi.org/10.1167/iovs.12-10314a
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