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Research Highlight

Can the OCT Replace Functional Tests Such as the mfERG? Free
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Anja Palmowski-Wolfe
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6129. doi:https://doi.org/10.1167/iovs.12-10795

Anatomy and Pathology/Oncology

Myelin Sheath Decompaction, Axon Swelling, and Functional Loss during Chronic Secondary Degeneration in Rat Optic Nerve Free
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Sophie C. Payne; Carole A. Bartlett; Alan R. Harvey; Sarah A. Dunlop; Melinda Fitzgerald
Tags: axon, edema, myelin, myelin sheath, wallerian degeneration
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6093-6101. doi:https://doi.org/10.1167/iovs.12-10080
Diurnal Rhythms of Spherical Refractive Error, Optical Axial Length, and Power in the Chick Free
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Melanie C. W. Campbell; Kaitlin Bunghardt; Marsha L. Kisilak; Elizabeth L. Irving
Tags: circadian rhythms, eye, optics, pupil size, refractive errors
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6245-6253. doi:https://doi.org/10.1167/iovs.11-8844

Biochemistry and Molecular Biology

Bidirectional, Optical Sign-Dependent Regulation of BMP2 Gene Expression in Chick Retinal Pigment Epithelium Free
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Yan Zhang; Yue Liu; Christine F. Wildsoet
Tags: eye, gene expression, lens (device), lens, crystalline, optics
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6072-6080. doi:https://doi.org/10.1167/iovs.12-9917
Altered Expression of the Poly(ADP-Ribosyl)ation Enzymes in Uveal Melanoma and Regulation of PARG Gene Expression by the Transcription Factor ERM Free
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Vanessa Molloy-Simard; Jean-François St-Laurent; François Vigneault; Manon Gaudreault; Natasha Dargis; Marie-Christine Guérin; Steeve Leclerc; Mohib Morcos; Daniel Black; Yvonne Molgat; Dan Bergeron; Yvan de Launoit; François Boudreau; Serge Desnoyers; Sylvain Guérin
Tags: cell lines, enzymes, poly(adp-ribose) polymerases, transcription factor, uveal melanoma
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6219-6231. doi:https://doi.org/10.1167/iovs.11-8853
Neuron-Specific Enolase Is Elevated in Asymptomatic Carriers of Leber's Hereditary Optic Neuropathy Free
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Kenneth M. Yee; Fred N. Ross-Cisneros; Jeong Goo Lee; Arlon Bastos Da Rosa; Solange R. Salomao; Adriana Berezovsky; Rubens Belfort, Jr; Filipe Chicani; Milton Moraes-Filho; Jerry Sebag; Valerio Carelli; Alfredo A. Sadun
Tags: carrier state, neuron-specific enolase, optic atrophy, hereditary, leber
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6389-6392. doi:https://doi.org/10.1167/iovs.12-9677
Do Lipids Retard the Evaporation of the Tear Fluid? Free
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Antti H. Rantamäki; Matti Javanainen; Ilpo Vattulainen; Juha M. Holopainen
Tags: evaporation, lipids, water
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6442-6447. doi:https://doi.org/10.1167/iovs.12-10487
Involvement of Periostin in Regression of Hyaloidvascular System during Ocular Development Free
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Mitsuru Arima; Shigeo Yoshida; Takahito Nakama; Keijiro Ishikawa; Shintaro Nakao; Takeru Yoshimura; Ryo Asato; Yukio Sassa; Takeshi Kita; Hiroshi Enaida; Yuji Oshima; Akira Matsuda; Akira Kudo; Tatsuro Ishibashi
Tags: eye development, macrophages, mice, vitreous body, monocytes
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6495-6503. doi:https://doi.org/10.1167/iovs.12-9684

Clinical and Epidemiologic Research

Macular Pigment Imaging in AREDS2 Participants: An Ancillary Study of AREDS2 Subjects Enrolled at the Moran Eye Center Free
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Paul S. Bernstein; Faisal Ahmed; Aihua Liu; Susan Allman; Xiaoming Sheng; Mohsen Sharifzadeh; Igor Ermakov; Werner Gellermann
Tags: carotenoids, diagnostic imaging, eye, lutein, pigment
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6178-6186. doi:https://doi.org/10.1167/iovs.12-10275
Intraocular VEGF Level as a Risk Factor for Postoperative Complications after Vitrectomy for Proliferative Diabetic Retinopathy Free
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Yoshihiro Wakabayashi; Yoshihiko Usui; Yoko Okunuki; Shunichiro Ueda; Keisuke Kimura; Daisuke Muramatsu; Takeshi Kezuka; Hiroshi Goto
Tags: postoperative complications, risk factors, vascular endothelial growth factor a, vitrectomy, proliferative diabetic retinopathy
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6403-6410. doi:https://doi.org/10.1167/iovs.12-10367
Axial Length Changes with Shifts of Gaze Direction in Myopes and Emmetropes Free
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Atanu Ghosh; Michael J. Collins; Scott A. Read; Brett A. Davis
Tags: gaze, eye, axl gene
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6465-6471. doi:https://doi.org/10.1167/iovs.12-9973
Prevalence of and Risk Factors for Pterygium in Rural Adult Chinese Populations of the Bai Nationality in Dali: The Yunnan Minority Eye Study Free
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Hua Zhong; Xueping Cha; Tao Wei; Xianchai Lin; Xun Li; Jun Li; Ning Cai; Juanjuan Li; Xiaodan Su; Yongming Yang; Minbin Yu; Yuansheng Yuan
Tags: chinese (other dialects), eye, prevalence, pterygium, risk factors
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6617-6621. doi:https://doi.org/10.1167/iovs.11-8947

Cornea

Fibrinogen, Riboflavin, and UVA to Immobilize a Corneal Flap – Molecular Mechanisms Free
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Stacy L. Littlechild; Yuntao Zhang; John M. Tomich; Gary W. Conrad
Tags: cornea, fibrinogen, proteins, riboflavin, surgical flaps
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 5991-6003. doi:https://doi.org/10.1167/iovs.12-10201
Seven-Year Changes in Corneal Power and Aberrations after PRK or LASIK Free
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Anders Ivarsen; Jesper Hjortdal
Tags: cornea, keratomileusis, laser in situ, surgical procedures, operative
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6011-6016. doi:https://doi.org/10.1167/iovs.12-10208
Detection of Prosecretory Mitogen Lacritin in Nonprimate Tears Primarily as a C-Terminal-Like Fragment Free
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Diane E. Laurie; Rebecca K. Splan; Kari Green; Katherine M. Still; Robert L. McKown; Gordon W. Laurie
Tags: equus caballus, growth factor, proteins, mitogens, equidae
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6130-6136. doi:https://doi.org/10.1167/iovs.11-8567
Protective Effects of Dispersive Viscoelastics on Corneal Endothelial Damage in a Toxic Anterior Segment Syndrome Animal Model Free
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Jong-Suk Song; Jeong-Hwa Heo; Hyo-Myung Kim
Tags: animal model, cornea, endothelium, toxic anterior segment syndrome, disinfectants
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6164-6170. doi:https://doi.org/10.1167/iovs.12-9945
In Vivo Oxygen Uptake into the Human Cornea Free
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Sho C. Takatori; Percy Lazon de la Jara; Brien Holden; Klaus Ehrmann; Arthur Ho; Clayton J. Radke
Tags: cornea, oxygen, tissue membrane
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6331-6337. doi:https://doi.org/10.1167/iovs.12-10059
A Short-Term In Vivo Experimental Model for Fuchs Endothelial Corneal Dystrophy Free
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M. Nour Haydari; Marie-Claude Perron; Simon Laprise; Olivier Roy; J. Douglas Cameron; Stéphanie Proulx; Isabelle Brunette
Tags: body tissue, cornea, endothelial cells, endothelium, hereditary corneal dystrophy
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6343-6354. doi:https://doi.org/10.1167/iovs.12-9708
Stiffening of Rabbit Corneas by the Bacteriochlorophyll Derivative WST11 Using Near Infrared Light Free
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Arie L. Marcovich; Alexander Brandis; Ofer Daphna; Ilan Feine; Iddo Pinkas; Ruth Goldschmidt; Vyacheslav Kalchenko; Tamara Berkutzki; H. Daniel Wagner; Yoram Salomon; Avigdor Scherz
Tags: cornea, oryctolagus cuniculus
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6378-6388. doi:https://doi.org/10.1167/iovs.12-9913
Ethyl Pyruvate Ameliorates Endotoxin-Induced Corneal Inflammation Free
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Divya Gupta; Yiqin Du; Jordan Piluek; Adam M. Jakub; Kristine Ann Buela; Akshar Abbott; Joel S. Schuman; Nirmala SundarRaj
Tags: anti-inflammatory agents, cornea, keratitis, mice, pyruvates
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6589-6599. doi:https://doi.org/10.1167/iovs.11-9266
Tear Lacritin Levels by Age, Sex, and Time of Day in Healthy Adults Free
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Kyle Seifert; Natasha C. Gandia; Jennifer K. Wilburn; Kraig S. Bower; Rose K. Sia; Denise S. Ryan; Michael L. Deaton; Katherine M. Still; Veronica C. Vassilev; Gordon W. Laurie; Robert L. McKown
Tags: adult, enzyme-linked immunosorbent assay, proteins, western blotting, antibodies
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6610-6616. doi:https://doi.org/10.1167/iovs.11-8729
Is Whole-Body Hydration an Important Consideration in Dry Eye? Free
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Neil P. Walsh; Matthew B. Fortes; Philippa Raymond-Barker; Claire Bishop; Julian Owen; Emma Tye; Marieh Esmaeelpour; Christine Purslow; Salah Elghenzai
Tags: dehydration, dry eye syndromes, mosmol, eye
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6622-6627. doi:https://doi.org/10.1167/iovs.12-10175
Introducing a New Parameter for the Assessment of the Tear Film Lipid Layer Free
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Michael H. Ring; Dieter F. Rabensteiner; Jutta Horwath-Winter; Ingrid Boldin; Robert Hörantner; Thomas Haslwanter
Tags: lipids, tear film finding, stabilization
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6638-6644. doi:https://doi.org/10.1167/iovs.12-10257
Endothelial Cdkn1a (p21) Overexpression and Accelerated Senescence in a Mouse Model of Fuchs Endothelial Corneal Dystrophy Free
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Mario Matthaei; Huan Meng; Alan K. Meeker; Charles G. Eberhart; Albert S. Jun
Tags: aging, endothelium, hereditary corneal dystrophy, mice, older adult
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6718-6727. doi:https://doi.org/10.1167/iovs.12-9669

Genetics

PAX6 Mutations Identified in 4 of 35 Families with Microcornea Free
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Panfeng Wang; Wenmin Sun; Shiqiang Li; Xueshan Xiao; Xiangming Guo; Qingjiong Zhang
Tags: family, microcornea, mutation
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6338-6342. doi:https://doi.org/10.1167/iovs.12-10472
Muscarinic Acetylcholine Receptor 3 Is Dominant in Myopia Progression Free
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Hui-Ju Lin; Lei Wan; Wen-Chi Chen; Jane-Ming Lin; Chao-Jen Lin; Fuu-Jen Tsai
Tags: muscarinic acetylcholine receptor, myopia, atropine
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6519-6525. doi:https://doi.org/10.1167/iovs.11-9031
Association of Genetic Variants on 8p21 and 4q12 with Age-Related Macular Degeneration in Asian Populations Free
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Isao Nakata; Kenji Yamashiro; Yumiko Akagi-Kurashige; Masahiro Miyake; Kyoko Kumagai; Akitaka Tsujikawa; Ke Liu; Li Jia Chen; David T. L. Liu; Timothy Y. Y. Lai; Yoichi Sakurada; Seigo Yoneyama; Ching-Yu Cheng; Peter Cackett; Ian Y. Yeo; Wan Ting Tay; Belinda K. Cornes; Eranga N. Vithana; Tin Aung; Keitaro Matsuo; Fumihiko Matsuda; Tien-Yin Wong; Hiroyuki Iijima; Chi Pui Pang; Nagahisa Yoshimura
Tags: age-related macular degeneration, asian, cohort studies, exudative age-related macular degeneration, genetics
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6576-6581. doi:https://doi.org/10.1167/iovs.12-10219

Glaucoma

The Relationship between Variability and Sensitivity in Large-Scale Longitudinal Visual Field Data Free
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Richard A Russell; David P Crabb; Rizwan Malik; David F Garway-Heath
Tags: visual fields
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 5985-5990. doi:https://doi.org/10.1167/iovs.12-10428
Impact of Glaucoma on Visual Functioning in Indians Free
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Vijaya K. Gothwal; Shailaja P. Reddy; Seelam Bharani; Deepak K. Bagga; Rebecca Sumalini; Chandra S. Garudadri; Harsha L. Rao; Sirisha Senthil; Vanita Pathak-Ray; Anil K. Mandal
Tags: glaucoma, questionnaires
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6081-6092. doi:https://doi.org/10.1167/iovs.12-9885
RPE-Normalized RNFL Attenuation Coefficient Maps Derived from Volumetric OCT Imaging for Glaucoma Assessment Free
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Koenraad A. Vermeer; Josine van der Schoot; Hans G. Lemij; Johannes F. de Boer
Tags: attenuation, diagnostic imaging, eye, glaucoma, maps
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6102-6108. doi:https://doi.org/10.1167/iovs.12-9933
A Novel Schlemm's Canal Scaffold Increases Outflow Facility in a Human Anterior Segment Perfusion Model Free
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Lucinda J. Camras; Fan Yuan; Shan Fan; Thomas W. Samuelson; Ike K. Ahmed; Andrew T. Schieber; Carol B. Toris
Tags: eye, implantation procedure, perfusion, schlemm's canal, intraocular pressure
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6115-6121. doi:https://doi.org/10.1167/iovs.12-9570
Retinal Nerve Fiber Layer Thickness Changes in Patients with Age-Related Macular Degeneration Treated with Intravitreal Ranibizumab Free
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Jose M. Martinez-de-la-Casa; Aurora Ruiz-Calvo; Federico Saenz-Frances; Juan Reche-Frutos; Cristina Calvo-Gonzalez; Juan Donate-Lopez; Julián Garcia-Feijoo
Tags: age-related macular degeneration, ranibizumab, retinal nerve fiber layer, follow-up, injections
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6214-6218. doi:https://doi.org/10.1167/iovs.12-9875
Tracking Retinal Microgliosis in Models of Retinal Ganglion Cell Damage Free
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Shu Liu; Zhi-wai Li; Robert N. Weinreb; Guihua Xu; James D. Lindsey; Cong Ye; Wing-ho Yung; Chi-Pui Pang; Dennis Shun Chiu Lam; Christopher Kai-shun Leung
Tags: diagnostic imaging, intraocular pressure, microglia, optic nerve, retinal ganglion cells
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6254-6262. doi:https://doi.org/10.1167/iovs.12-9450
Lack of Immunoglobulins Does Not Prevent C1q Binding to RGC and Does Not Alter the Progression of Experimental Glaucoma Free
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Qiong J. Ding; Amy C. Cook; Alina V. Dumitrescu; Markus H. Kuehn
Tags: glaucoma, immunoglobulins, mice, complement system proteins, raised intraocular pressure
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6370-6377. doi:https://doi.org/10.1167/iovs.12-10442
Choroidal Thickness Change after Water Drinking Is Greater in Angle Closure than in Open Angle Eyes Free
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Karun S. Arora; Joan L. Jefferys; Eugenio A. Maul; Harry A. Quigley
Tags: eye, intraocular pressure, water drinking, choroid
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6393-6402. doi:https://doi.org/10.1167/iovs.12-10224
The Relationship between Caffeine and Coffee Consumption and Exfoliation Glaucoma or Glaucoma Suspect: A Prospective Study in Two Cohorts Free
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Louis R. Pasquale; Janey L. Wiggs; Walter C. Willett; Jae H. Kang
Tags: caffeine, coffee, cohort studies, glaucoma, peeling of skin
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6427-6433. doi:https://doi.org/10.1167/iovs.12-10085
Retinal Nerve Fiber Layer Defects in Highly Myopic Eyes with Early Glaucoma Free
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Yugo Kimura; Masanori Hangai; Satoshi Morooka; Kohei Takayama; Noriko Nakano; Masayuki Nukada; Hanako Ohashi Ikeda; Tadamichi Akagi; Nagahisa Yoshimura
Tags: eye, glaucoma, myopia, retinal nerve fiber layer, scotoma
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6472-6478. doi:https://doi.org/10.1167/iovs.12-10319
Auditory and Visual Temporal Processing Disruption in Open Angle Glaucoma Free
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Fleur O'Hare; Gary Rance; Jonathan G. Crowston; Allison M. McKendrick
Tags: frequency discrimination, glaucoma, hearing, motion, open-angle glaucoma
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6512-6518. doi:https://doi.org/10.1167/iovs.12-10188
Progression of Patterns (POP): A Machine Classifier Algorithm to Identify Glaucoma Progression in Visual Fields Free
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Michael H. Goldbaum; Intae Lee; Giljin Jang; Madhusudhanan Balasubramanian; Pamela A. Sample; Robert N. Weinreb; Jeffrey M. Liebmann; Christopher A. Girkin; Douglas R. Anderson; Linda M. Zangwill; Marie-Josee Fredette; Tzyy-Ping Jung; Felipe A. Medeiros; Christopher Bowd
Tags: eye, glaucoma, visual fields
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6557-6567. doi:https://doi.org/10.1167/iovs.11-8363
Choroidal Thickness in Unilateral Advanced Glaucoma Free
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Jean-Claude Mwanza; Fouad E. Sayyad; Donald L. Budenz
Tags: eye, glaucoma
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6695-6701. doi:https://doi.org/10.1167/iovs.12-10388
The Effect of Monocyte Chemoattractant Protein-1/CC Chemokine Ligand 2 on Aqueous Humor Outflow Facility Free
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Naoko Tsuboi; Toshihiro Inoue; Motofumi Kawai; Miyuki Inoue-Mochita; Tomokazu Fujimoto; Nanako Awai-Kasaoka; Akitoshi Yoshida; Hidenobu Tanihara
Tags: monocyte chemoattractant protein-1, aqueous humor, ligands, beta-chemokines
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6702-6707. doi:https://doi.org/10.1167/iovs.12-10376
Thrombospondin-1 (TSP1)–Null and TSP2-Null Mice Exhibit Lower Intraocular Pressures Free
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Ramez I. Haddadin; Dong-Jin Oh; Min Hyung Kang; Guadalupe Villarreal, Jr; Ja-Heon Kang; Rui Jin; Haiyan Gong; Douglas J. Rhee
Tags: intraocular pressure, mice, thrombospondin 1
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6708-6717. doi:https://doi.org/10.1167/iovs.11-9013

Immunology and Microbiology

Effect of Photodynamic Therapy with Methylene Blue on Acanthamoeba In Vitro Free
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Tsuyoshi Mito; Takashi Suzuki; Takeshi Kobayashi; Xiaodong Zheng; Yasuhito Hayashi; Atsushi Shiraishi; Yuichi Ohashi
Tags: acanthamoeba, methylene blue, photochemotherapy, trophozoite, riboflavin
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6305-6313. doi:https://doi.org/10.1167/iovs.12-9828
The Role of Type III Secretion System and Lens Material on Adhesion of Pseudomonas aeruginosa to Contact Lenses Free
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Elizabeth P. Shen; Ruey-Yug Tsay; Jean-San Chia; Semon Wu; Jing-Wen Lee; Fung-Rong Hu
Tags: adhesions, contact lenses, lens (device), lens, crystalline, type iii protein secretion system complex
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6416-6426. doi:https://doi.org/10.1167/iovs.11-8184
Effect of 1,25-Dihydroxyvitamin D3 on Th17 and Th1 Response in Patients with Behçet's Disease Free
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Yuan Tian; Chaokui Wang; Zi Ye; Xiang Xiao; Aize Kijlstra; Peizeng Yang
Tags: behcet syndrome, interleukin-17, th17 cells, t-lymphocytes, interleukin-10
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6434-6441. doi:https://doi.org/10.1167/iovs.12-10398

Lens

Elastic Properties of Human Lens Zonules as a Function of Age in Presbyopes Free
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Ralph Michael; Marek Mikielewicz; Carlos Gordillo; Gustavo A. Montenegro; Laura Pinilla Cortés; Rafael I. Barraquer
Tags: elasticity, eye, lens, crystalline, manganese, presbyopia
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6109-6114. doi:https://doi.org/10.1167/iovs.11-8702
Enhancement of Ubiquitin Conjugation Activity Reduces Intracellular Aggregation of V76D Mutant γD-Crystallin Free
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Zhenzhen Liu; Allen Taylor; Yizhi Liu; Mingxing Wu; Xiaohua Gong; Fu Shang
Tags: crystallins, proteins, ubiquitin
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6655-6665. doi:https://doi.org/10.1167/iovs.12-9744
Enhancement of Ubiquitin Conjugation Activity Reduces Intracellular Aggregation of V76D Mutant γD-Crystallin Free
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Zhenzhen Liu; Allen Taylor; Yizhi Liu; Mingxing Wu; Xiaohua Gong; Fu Shang
Tags: crystallins, proteins, ubiquitin
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6655-6665. doi:https://doi.org/10.1167/iovs.12-9744

Low Vision

Street-Crossing Decision-Making: A Comparison between Patients with Age-Related Macular Degeneration and Normal Vision Free
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Shirin E. Hassan; Benjamin D. Snyder
Tags: age-related macular degeneration, decision making, emmetropia, precision, blindness
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6137-6144. doi:https://doi.org/10.1167/iovs.12-10023
Visual Search with Image Modification in Age-Related Macular Degeneration Free
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Emily Wiecek; Mary Lou Jackson; Steven C. Dakin; Peter Bex
Tags: age-related macular degeneration, visual search, image enhancement, scotoma
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6600-6609. doi:https://doi.org/10.1167/iovs.12-10012
How Do Flanking Objects Affect Reaching and Grasping Behavior in Participants with Macular Disorders? Free
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Shahina Pardhan; Carmen Gonzalez-Alvarez; Ahalya Subramanian; Susana T. L. Chung
Tags: biological transport, crowding, macular disorders, emmetropia, velocity
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6687-6694. doi:https://doi.org/10.1167/iovs.12-9821

Multidisciplinary Ophthalmic Imaging

Measurement of Absolute Blood Flow Velocity and Blood Flow in the Human Retina by Dual-Beam Bidirectional Doppler Fourier-Domain Optical Coherence Tomography Free
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René M. Werkmeister; Nikolaus Dragostinoff; Stefan Palkovits; Reinhard Told; Agnes Boltz; Rainer A. Leitgeb; Martin Gröschl; Gerhard Garhöfer; Leopold Schmetterer
Tags: blood flow velocity, fluid flow, optical coherence tomography, retina, vascular flow
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6062-6071. doi:https://doi.org/10.1167/iovs.12-9514

Physiology and Pharmacology

A Microparticle/Hydrogel Combination Drug-Delivery System for Sustained Release of Retinoids Free
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Song-Qi Gao; Tadao Maeda; Kiichiro Okano; Krzysztof Palczewski
Tags: cell-derived microparticles, drug delivery systems, electroretinography, hydrogel, mice
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6314-6323. doi:https://doi.org/10.1167/iovs.12-10279

Retina

Anti-Inflammatory Effects of Lutein in Retinal Ischemic/Hypoxic Injury: In Vivo and In Vitro Studies Free
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Suk-Yee Li; Frederic K. C. Fung; Zhong Jie Fu; David Wong; Henry H. L. Chan; Amy C. Y. Lo
Tags: anti-inflammatory agents, hypoxia, ischemia, lutein, wounds and injuries
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 5976-5984. doi:https://doi.org/10.1167/iovs.12-10007
Enhanced Depth Imaging Optical Coherence Tomography in Type 2 Diabetes Free
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Giuseppe Querques; Rosangela Lattanzio; Lea Querques; Claudia Del Turco; Raimondo Forte; Luisa Pierro; Eric H. Souied; Francesco Bandello
Tags: choroid, diabetes mellitus, diabetes mellitus, type 2, diabetic retinopathy, diagnostic imaging
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6017-6024. doi:https://doi.org/10.1167/iovs.12-9692
Effects of Erythropoietin-Dextran Microparticle-Based PLGA/PLA Microspheres on RGCs Free
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Xianfang Rong; Sixing Yang; Huamao Miao; Tingting Guo; Zhenyu Wang; Wanru Shi; Xiaofen Mo; Weien Yuan; Tuo Jin
Tags: dextran, microspheres, erythropoietin
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6025-6034. doi:https://doi.org/10.1167/iovs.12-9898
Functional and Morphologic Consequences of Light Exposure in Primate Eyes Free
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Ryo Mukai; Hideo Akiyama; Yuki Tajika; Yukitoshi Shimoda; Hiroshi Yorifuji; Shoji Kishi
Tags: eye, light exposure, primates, electroretinography
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6035-6044. doi:https://doi.org/10.1167/iovs.12-9608
Association between Shape of Sclera and Myopic Retinochoroidal Lesions in Patients with Pathologic Myopia Free
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Kyoko Ohno-Matsui; Masahiro Akiba; Toshio Modegi; Makoto Tomita; Tatsuro Ishibashi; Takashi Tokoro; Muka Moriyama
Tags: eye, sclera, myopic macular degeneration, fovea centralis
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6046-6061. doi:https://doi.org/10.1167/iovs.12-10161
Associations between Local Retinal Thickness and Function in Early Diabetes Free
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Kavita P. Dhamdhere; Marcus A. Bearse, Jr; Wendy Harrison; Shirin Barez; Marilyn E. Schneck; Anthony J. Adams
Tags: diabetes mellitus, diabetes mellitus, type 2, retinal diseases
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6122-6128. doi:https://doi.org/10.1167/iovs.12-10293
“En face” OCT Imaging of the IS/OS Junction Line in Type 2 Idiopathic Macular Telangiectasia Free
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Ferenc B. Sallo; Tunde Peto; Catherine Egan; Ute E. K. Wolf-Schnurrbusch; Traci E. Clemons; Mark C. Gillies; Daniel Pauleikhoff; Gary S. Rubin; Emily Y. Chew; Alan C. Bird; the MacTel Study Group10
Tags: diagnostic imaging, eye, face, telangiectasis
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6145-6152. doi:https://doi.org/10.1167/iovs.12-10580
Retinal Thickening in HLA-B27–Associated Acute Anterior Uveitis: Evolution with Time and Association with Severity of Inflammatory Activity Free
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Konstantinos Balaskas; Pierluigi Ballabeni; Yan Guex-Crosier
Tags: eye, follow-up, hla-b27 antigen, uveitis, anterior, inflammation
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6171-6177. doi:https://doi.org/10.1167/iovs.12-10026
Comparison of Fundus Autofluorescence with Photopic and Scotopic Fine Matrix Mapping in Patients with Retinitis Pigmentosa: 4- to 8-Year Follow-up Free
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Anthony G. Robson; Eva Lenassi; Zubin Saihan; Vy A. Luong; Fred W. Fitzke; Graham E. Holder; Andrew R. Webster
Tags: follow-up, fundus autofluorescence imaging, retinitis pigmentosa
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6187-6195. doi:https://doi.org/10.1167/iovs.12-10195
Impacts of Hypoxia-Inducible Factor-1 Knockout in the Retinal Pigment Epithelium on Choroidal Neovascularization Free
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Mingkai Lin; Yang Hu; Ying Chen; Kevin K. Zhou; Ji Jin; Meili Zhu; Yun-Zheng Le; Jian Ge; Jian-xing Ma
Tags: choroidal neovascularization, lasers, mice, hypoxia-inducible factor 1, retinal pigment epithelium
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6197-6206. doi:https://doi.org/10.1167/iovs.11-8936
Effect of Glial Cell Line-Derived Neurotrophic Factor on Retinal Function after Experimental Branch Retinal Vein Occlusion Free
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Rasmus Ejstrup; Morten la Cour; Maria Voss Kyhn; Steffen Heegaard; Jens Folke Kiilgaard
Tags: glial cell-line derived neurotrophic factor, venous retinal branch occlusion, eye
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6207-6213. doi:https://doi.org/10.1167/iovs.12-10110
Multifocal Electroretinography in Eyes with Reticular Pseudodrusen Free
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Florian Alten; Peter Heiduschka; Christoph R. Clemens; Nicole Eter
Tags: electroretinography, eye
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6263-6270. doi:https://doi.org/10.1167/iovs.12-10094
Shape Change of the Vitreous Chamber Influences Retinal Detachment and Reattachment Processes: Is Mechanical Stress during Eye Rotations a Factor? Free
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Julia Meskauskas; Rodolfo Repetto; Jennifer H. Siggers
Tags: eye, retina, stress, vitreous body, retinal detachment
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6271-6281. doi:https://doi.org/10.1167/iovs.11-9390
Visual Cortex Responses to Single- and Simultaneous Multiple-Electrode Stimulation of the Retina: Implications for Retinal Prostheses Free
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Mohit N. Shivdasani; James B. Fallon; Chi D. Luu; Rosemary Cicione; Penny J. Allen; John W. Morley; Chris E. Williams
Tags: retina, visual cortex, visual prosthesis, voltage
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6291-6300. doi:https://doi.org/10.1167/iovs.12-9434
Correlation of SD-OCT Features and Retinal Sensitivity in Neovascular Age-Related Macular Degeneration Free
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Florian Sulzbacher; Christopher Kiss; Alexandra Kaider; Stefan Eisenkoelbl; Marion Munk; Philipp Roberts; Stefan Sacu; Ursula Schmidt-Erfurth
Tags: exudative age-related macular degeneration, language morphology, morphology, eye, photoreceptors
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6448-6455. doi:https://doi.org/10.1167/iovs.11-9162
Reduced Ocular Blood Flow as an Early Indicator of Diabetic Retinopathy in a Mouse Model of Diabetes Free
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Eric R. Muir; René C. Rentería; Timothy Q. Duong
Tags: diabetes mellitus, diabetic retinopathy, magnetic resonance imaging, mice, vascular flow
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6488-6494. doi:https://doi.org/10.1167/iovs.12-9758
Characterization of Vitreoretinal Interface Disorders Using OCT in the Interventional Phase 3 Trials of Ocriplasmin Free
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Francis Char DeCroos; Cynthia A. Toth; Francisco A. Folgar; Stephen Pakola; Sandra S. Stinnett; Cynthia S. Heydary; Russell Burns; Glenn J. Jaffe
Tags: adhesions, ocriplasmin, vitreoretinal disease, vitreous body, vitreomacular adhesions
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6504-6511. doi:https://doi.org/10.1167/iovs.12-10370
Prevalence of Peripheral Abnormalities on Ultra-Widefield Greenlight (532 nm) Autofluorescence Imaging at a Tertiary Care Center Free
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Florian M. Heussen; Colin S. Tan; SriniVas R. Sadda
Tags: autofluorescence, diagnostic imaging, prevalence, tertiary care hospitals, eye
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6526-6531. doi:https://doi.org/10.1167/iovs.12-9909
Macular Pigment Parameters in Patients with Macular Telangiectasia (MacTel) and Normal Subjects: Implications of a Novel Analysis Free
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Simona Degli Esposti; Catherine Egan; Catey Bunce; Jack D. Moreland; Alan C. Bird; Anthony G. Robson
Tags: pigment, telangiectasis, complement system proteins
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6568-6575. doi:https://doi.org/10.1167/iovs.12-9756
Automated Detection of Malarial Retinopathy-Associated Retinal Hemorrhages Free
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Vinayak S. Joshi; Richard J. Maude; Joseph M. Reinhardt; Li Tang; Mona K. Garvin; Abdullah Abu Sayeed; Aniruddha Ghose; Mahtab Uddin Hassan; Michael D. Abràmoff
Tags: hemorrhage, retinal diseases, retinal hemorrhage, reference standards
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6582-6588. doi:https://doi.org/10.1167/iovs.12-10191
Activation of the Alternative Complement Pathway in Vitreous is Controlled by Genetics in Age-Related Macular Degeneration Free
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Kelly M. Loyet; Laura E. DeForge; Kenneth J. Katschke, Jr; Lauri Diehl; Robert R. Graham; Lily Pao; Lizette Sturgeon; Sock-Cheng Lewin-Koh; Joe G. Hollyfield; Menno van Lookeren Campagne
Tags: age-related macular degeneration, complement activation, complement pathway, alternative, complement system proteins, eye
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6628-6637. doi:https://doi.org/10.1167/iovs.12-9587
Segmentational Analysis of Retinal Thickness after Vitrectomy in Diabetic Macular Edema Free
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Tomoaki Murakami; Kazuaki Nishijima; Tadamichi Akagi; Akihito Uji; Takahiro Horii; Naoko Ueda-Arakawa; Yuki Muraoka; Nagahisa Yoshimura
Tags: diabetic macular edema, vitrectomy, optical coherence tomography
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6668-6674. doi:https://doi.org/10.1167/iovs.12-9934
Visualization of the Optic Fissure in Short-Wavelength Autofluorescence Images of the Fundus Free
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Tobias Duncker; Jonathan P. Greenberg; Janet R. Sparrow; R. Theodore Smith; Harry A. Quigley; François C. Delori
Tags: autofluorescence, eye, fissure, nose, optics
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6682-6686. doi:https://doi.org/10.1167/iovs.12-10004

Retinal Cell Biology

Complement Factor H Deficiency Results in Decreased Neuroretinal Expression of Cd59a in Aged Mice Free
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Carsten Faber; Jennifer Williams; Helene Bæk Juel; John Greenwood; Mogens Holst Nissen; Stephen E. Moss
Tags: choroid, complement system proteins, factor h deficiency, genes, mice
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6324-6330. doi:https://doi.org/10.1167/iovs.12-10385
Mislocalized Opsin and cAMP Signaling: A Mechanism for Sprouting by Rod Cells in Retinal Degeneration Free
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Jianfeng Wang; Nan Zhang; Annie Beuve; Ellen Townes-Anderson
Tags: cyclic amp, opsin, retinal degeneration, rod photoreceptors, signal transduction
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6355-6369. doi:https://doi.org/10.1167/iovs.12-10180
The C Allele of −634G/C Polymorphism in the VEGFA Gene Is Associated with Increased VEGFA Gene Expression in Human Retinal Tissue Free
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Fabiana B. Vailati; Daisy Crispim; Denise A. Sortica; Bianca M. Souza; Letícia A. Brondani; Luís H. Canani
Tags: alleles, body tissue, gene expression, genes, polymorphism
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6411-6415. doi:https://doi.org/10.1167/iovs.12-9727
Effects of Simvastatin on the Expression of Heme Oxygenase-1 in Human RPE Cells Free
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Kyoung Jin Kim; Kyong Sil Kim; Na Rae Kim; Hee Seung Chin
Tags: retinal pigment cell, simvastatin, heme, oxygenases, proteins
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6456-6464. doi:https://doi.org/10.1167/iovs.12-9658
Pharmacologic Induction of Heme Oxygenase-1 Plays a Protective Role in Diabetic Retinopathy in Rats Free
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Jiawen Fan; Gezhi Xu; Tingting Jiang; Yaowu Qin
Tags: diabetes mellitus, hemin, rats, retina, proteins
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6541-6556. doi:https://doi.org/10.1167/iovs.11-9241
Reactive Oxygen Species Regulate Prosurvival ERK1/2 Signaling and bFGF Expression in Gliosis within the Retina Free
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Gillian Groeger; Francesca Doonan; Thomas G. Cotter; Maryanne Donovan
Tags: fibroblast growth factor 2, gliosis, reactive oxygen species, regulation, retina
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6645-6654. doi:https://doi.org/10.1167/iovs.12-10525
Downregulation of Mitochondrial Connexin 43 by High Glucose Triggers Mitochondrial Shape Change and Cytochrome c Release in Retinal Endothelial Cells Free
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Kyle Trudeau; Tetsuya Muto; Sayon Roy
Tags: connexin 43, cytochrome c, endothelial cells, glucose, mitochondria
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6675-6681. doi:https://doi.org/10.1167/iovs.12-9895
SEMA4A Mutations Lead to Susceptibility to Light Irradiation, Oxidative Stress, and ER Stress in Retinal Pigment Epithelial Cells Free
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Kazuhiro Tsuruma; Yuhei Nishimura; Seiya Kishi; Masamitsu Shimazawa; Toshio Tanaka; Hideaki Hara
Tags: disease susceptibility, mutation, oxidative stress, stress, retinal pigment cell
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6729-6737. doi:https://doi.org/10.1167/iovs.11-9378

Translational

Using Flow Cytometry to Compare the Dynamics of Photoreceptor Outer Segment Phagocytosis in iPS-Derived RPE Cells Free
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Peter D. Westenskow; Stacey K. Moreno; Tim U. Krohne; Toshihide Kurihara; Saiyong Zhu; Zhen-ning Zhang; Tongbiao Zhao; Yang Xu; Sheng Ding; Martin Friedlander
Tags: flow cytometry, phagocytosis, photoreceptors, retinal pigment cell
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6282-6290. doi:https://doi.org/10.1167/iovs.12-9721

Visual Neuroscience

Reproducibility of Activation Maps for Longitudinal Studies of Visual Function by Functional Magnetic Resonance Imaging Free
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Jing Ming; Keith R. Thulborn; Janet P. Szlyk
Tags: functional magnetic resonance imaging, vision, longitudinal studies, eye movement, saccades
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6153-6163. doi:https://doi.org/10.1167/iovs.11-8375
Age-Related Changes in the Pattern Electroretinogram of Normal and Glatiramer Acetate–Immunized Rats Free
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Shai Sandalon; Ron Ofri
Tags: electroretinography, glatiramer acetate, immunization, rats, cop i
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6532-6540. doi:https://doi.org/10.1167/iovs.12-10103

Visual Psychophysics and Physiological Optics

Image Jitter Enhances Visual Performance when Spatial Resolution Is Impaired Free
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Lynne M. Watson; Niall C. Strang; Fraser Scobie; Gordon D. Love; Dirk Seidel; Velitchko Manahilov
Tags: jitter, visual impairment, word recognition
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6004-6010. doi:https://doi.org/10.1167/iovs.11-9157
Discordant Anatomical, Electrophysiological, and Visual Behavioral Profiles of Retinal Degeneration in Rat Models of Retinal Degenerative Disease Free
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Trevor J. McGill; Glen T. Prusky; Robert M. Douglas; Douglas Yasumura; Michael T. Matthes; Robert J. Lowe; Jacque L. Duncan; Haidong Yang; Kelly Ahern; Kate M. Daniello; Byron Silver; Matthew M. LaVail
Tags: degenerative disorders, electroretinography, photoreceptors, rats, retinal degeneration
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6232-6244. doi:https://doi.org/10.1167/iovs.12-9569
The Effect of Simultaneous Negative and Positive Defocus on Eye Growth and Development of Refractive State in Marmosets Free
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Alexandra Benavente-Perez; Ann Nour; David Troilo
Tags: callithrix, eye, growth and development, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6479-6487. doi:https://doi.org/10.1167/iovs.12-9822

Letters to the Editor

Retinal Vein Pulsation is in Phase with Intracranial Pressure and not Intraocular Pressure Free
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Jost B. Jonas; Ningli Wang; Diya Yang
Tags: central retinal vein, intracranial pressure, intraocular pressure
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6045. doi:https://doi.org/10.1167/iovs.12-10623
Generating a Random Sequence of Left and Right Eyes for Ophthalmic Research Free
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Simon Dulku
Tags: eye
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6301-6302. doi:https://doi.org/10.1167/iovs.12-10737
Profiles of Macular Pigment Optical Density and Their Changes Following Supplemental Lutein and Zeaxannthin Free
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John Nolan; Stephen Beatty
Tags: lutein, optics, pigment
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6303. doi:https://doi.org/10.1167/iovs.12-10674
Author Response: Profiles of Macular Pigment Optical Density and Their Changes following Supplemental Lutein and Zeaxanthin Free
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Meike Zeimer; Martha Dietzel; Hans-Werner Hense; Daniel Pauleikhoff
Tags: lutein, optics, pigment
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6304. doi:https://doi.org/10.1167/iovs.12-10780
Author Response: Nonspecific PCR Amplification of CRYBB2-Pseudogene Leads to Misconception of Natural Variation as Mutation Free
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Lars Hansen; Thomas Rosenberg
Tags: amplification, misconceptions, mutation, polymerase chain reaction, pseudogenes
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6666. doi:https://doi.org/10.1167/iovs.12-10751
The Novel Human p.I587V Variant in the ZNF644 Gene Is Unlikely to Be the Pathogenic Cause of Dominantly Inherited High Myopia in a Chinese Patient Free
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Emily Jamieson; Douglas Lester
Tags: chinese (other dialects), chinese people, genes, myopia
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6728. doi:https://doi.org/10.1167/iovs.12-10492

Erratum

Erratum Free
PDF
Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6196. doi:https://doi.org/10.1167/iovs.11-8219a
Erratum Free
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Investigative Ophthalmology & Visual Science September 2012, Vol.53, 6667. doi:https://doi.org/10.1167/iovs.08-3149a
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