Volume 53 Issue 12 | IOVS

Research Highlight

Fluid in Equals Fluid Out—Evidence for Circulating Fluid Fluxes in the Lens Free

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Paul J. Donaldson

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7727. doi:https://doi.org/10.1167/iovs.12-11012

Anatomy and Pathology/Oncology

Mapping the Differential Distribution of Proteoglycan Core Proteins in the Adult Human Retina, Choroid, and Sclera Free

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Tiarnan D. L. Keenan; Simon J. Clark; Richard D. Unwin; Liam A. Ridge; Anthony J. Day; Paul N. Bishop

Tags: body tissue, choroid, proteins, proteoglycan, retina

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7528-7538. doi:https://doi.org/10.1167/iovs.12-10797

Mathematically Modeling the Involvement of Axons in Leber's Hereditary Optic Neuropathy Free

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Billy X. Pan; Fred N. Ross-Cisneros; Valerio Carelli; Kelly S. Rue; Solange R. Salomao; Milton N. Moraes-Filho; Milton N. Moraes; Adriana Berezovsky; Rubens Belfort, Jr; Alfredo A. Sadun

Tags: axon, optic atrophy, hereditary, leber, optic nerve, optic nerve disorders, stress

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7608-7617. doi:https://doi.org/10.1167/iovs.12-10452

Validating a Nonhuman Primate Model of Super-Selective Intraophthalmic Artery Chemotherapy: Comparing Ophthalmic Artery Diameters Free

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Lauren C. Ditta; Asim F. Choudhri; Brian C. Tse; Mark M. Landers; Barrett G. Haik; Jena J. Steinle; J. Scott Williams; Matthew W. Wilson

Tags: chemotherapy regimen, ophthalmic artery, pediatrics, primates, retinoblastoma

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7791-7794. doi:https://doi.org/10.1167/iovs.12-10605

Biochemistry and Molecular Biology

Expression and Role of VEGF-A in the Ciliary Body Free

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Knatokie M. Ford; Magali Saint-Geniez; Tony E. Walshe; Patricia A. D'Amore

Tags: ciliary body, vascular endothelial growth factor a

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7520-7527. doi:https://doi.org/10.1167/iovs.12-10098

In Vitro Effects of Bevacizumab Treatment on Newborn Rat Retinal Cell Proliferation, Death, and Differentiation Free

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Nádia C. O. Miguel; Monique Matsuda; André Luís F. Portes; Silvana Allodi; Rosália Mendez-Otero; Thiago Puntar; Alfred Sholl-Franco; Paloma G. Krempel; Mário L. R. Monteiro

Tags: bevacizumab, newborn, cell proliferation, glial fibrillary acidic protein, vimentin

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7904-7911. doi:https://doi.org/10.1167/iovs.12-10283

Clinical and Epidemiologic Research

Two-Year Intraocular Delivery of Ciliary Neurotrophic Factor by Encapsulated Cell Technology Implants in Patients with Chronic Retinal Degenerative Diseases Free

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Konrad Kauper; Cahil McGovern; Sandy Sherman; Pam Heatherton; Rob Rapoza; Paul Stabila; Brenda Dean; Alice Lee; Suzanna Borges; Bruce Bouchard; Weng Tao

Tags: ciliary neurotrophic factor, implants, degenerative disorders

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7484-7491. doi:https://doi.org/10.1167/iovs.12-9970

High Prevalence of Myopia and High Myopia in 5060 Chinese University Students in Shanghai Free

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Jing Sun; Jibo Zhou; Peiquan Zhao; Jingcai Lian; Huang Zhu; Yixiong Zhou; Yue Sun; Yefei Wang; Liquan Zhao; Yan Wei; Lina Wang; Biyun Cun; Shengfang Ge; Xianqun Fan

Tags: chinese (other dialects), college students, myopia, prevalence, student

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7504-7509. doi:https://doi.org/10.1167/iovs.11-8343

The Epidemiology and Incidence of Cytomegalovirus Retinitis in the HIV Population in Singapore over 6 Years Free

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Stephen C. Teoh; Priscilla X. Wang; Elizabeth P. Y. Wong

Tags: cytomegalovirus retinitis, epidemiology, hiv, incidence, singapore

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7546-7552. doi:https://doi.org/10.1167/iovs.12-10349

Education Is Positively Associated with Macular Pigment: The Irish Longitudinal Study on Ageing (TILDA) Free

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John M. Nolan; Joanne Feeney; Rose Anne Kenny; Hilary Cronin; Claire O'Regan; George M. Savva; James Loughman; Ciaran Finucane; Eithne Connolly; Katie Meagher; Stephen Beatty

Tags: aging, health, knowledge acquisition, longitudinal studies, pigment

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7855-7861. doi:https://doi.org/10.1167/iovs.11-9367

Cornea

Notch Inhibition during Corneal Epithelial Wound Healing Promotes Migration Free

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Asadolah Movahedan; Mercede Majdi; Neda Afsharkhamseh; Hossein M. Sagha; Niloufar S. Saadat; Keivan Shalileh; Behrad Y. Milani; Hongyu Ying; Ali R. Djalilian

Tags: cornea, epithelium, notch1 gene, wound healing, corneal epithelial cells

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7476-7483. doi:https://doi.org/10.1167/iovs.12-10735

Role of Hepatocyte Growth Factor in Promoting the Growth of Human Corneal Endothelial Cells Stimulated by l-Ascorbic Acid 2-Phosphate Free

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Miwa Kimoto; Nobuyuki Shima; Masahiro Yamaguchi; Shiro Amano; Satoru Yamagami

Tags: ambulatory surgery center, cornea, endothelial cells, hepatocyte growth factor, phosphates

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7583-7589. doi:https://doi.org/10.1167/iovs.12-10146

Bevacizumab and Rapamycin Can Decrease Corneal Opacity and Apoptotic Keratocyte Number following Photorefractive Keratectomy Free

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Kyoung Sub Lee; Dong-Ah Ko; Eun-Soon Kim; Myoung Joon Kim; Hungwon Tchah; Jae Yong Kim

Tags: bevacizumab, corneal opacity, keratocytes, rapamycin, cornea

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7645-7653. doi:https://doi.org/10.1167/iovs.12-10494

Ectopic Epithelial Implants following Surface Ablation of the Cornea Free

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Daniel J. Gibson; Gregory S. Schultz

Tags: ablation, cornea, epithelium, implants, wound healing

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7760-7765. doi:https://doi.org/10.1167/iovs.12-10768

Relaxin 2 Is Functional at the Ocular Surface and Promotes Corneal Wound Healing Free

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Ulrike Hampel; Thomas Klonisch; Eugenia Makrantonaki; Saadettin Sel; Ute Schulze; Fabian Garreis; Holger Seltmann; Christos C. Zouboulis; Friedrich P. Paulsen

Tags: body tissue, cornea, gelatinase a, gelatinase b, relaxin

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7780-7790. doi:https://doi.org/10.1167/iovs.12-10714

Short-Term Effects of Extremely Low Frequency Pulsed Electromagnetic Field on Corneas with Alkaline Burns in Rabbits Free

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Mozhgan Rezaei Kanavi; Farzin Sahebjam; Faraj Tabeie; Paniz Davari; Aminpasha Samadian; Mehdi Yaseri

Tags: alkaline chemical burns, burns, cornea, electromagnetic fields, oryctolagus cuniculus

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7881-7888. doi:https://doi.org/10.1167/iovs.12-10248

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Effects of Strabismic Amblyopia and Strabismus without Amblyopia on Visuomotor Behavior, I: Saccadic Eye Movements Free

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Ewa Niechwiej-Szwedo; Manokaraananthan Chandrakumar; Herbert C. Goltz; Agnes M. F. Wong

Tags: amblyopia, saccades, strabismic amblyopia, strabismus, depth perception

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7458-7468. doi:https://doi.org/10.1167/iovs.12-10550

Axial Elongation following Cataract Surgery during the First Year of Life in the Infant Aphakia Treatment Study Free

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Scott R. Lambert; Michael J. Lynn; Lindreth G. DuBois; George A. Cotsonis; E. Eugenie Hartmann; M. Edward Wilson

Tags: aphakia, cataract surgery, eye, infant, surgical procedures, operative

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7539-7545. doi:https://doi.org/10.1167/iovs.12-10285

Axonal Protection via Modulation of the Amyloidogenic Pathway in Tumor Necrosis Factor–Induced Optic Neuropathy Free

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Kaori Kojima; Yasushi Kitaoka; Yasunari Munemasa; Satoki Ueno

Tags: optic nerve, tumor necrosis factors, optic nerve disorders

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7675-7683. doi:https://doi.org/10.1167/iovs.12-10271

Genetics

The UCP1 −3826A/G Polymorphism Is Associated with Diabetic Retinopathy and Increased UCP1 and MnSOD2 Gene Expression in Human Retina Free

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Letícia A. Brondani; Bianca M. de Souza; Guilherme C. K. Duarte; Lúcia M. Kliemann; Jorge F. Esteves; Alexandre S. Marcon; Jorge L. Gross; Luís H. Canani; Daisy Crispim

Tags: diabetic retinopathy, gene expression, polymorphism, retina, ucp1 gene

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7449-7457. doi:https://doi.org/10.1167/iovs.12-10660

Polymorphisms in ARMS2/HTRA1 and Complement Genes and Age-Related Macular Degeneration in India: Findings from the INDEYE Study Free

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Periasamy Sundaresan; Praveen Vashist; Ravilla D. Ravindran; Ashwini Shanker; Dorothea Nitsch; Bareng A. S. Nonyane; Liam Smeeth; Usha Chakravarthy; Astrid E. Fletcher

Tags: age-related macular degeneration, complement system proteins, genes, htra1 gene, india

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7492-7497. doi:https://doi.org/10.1167/iovs.12-10073

Glaucoma

Structure-Function Relationship between FDF, FDT, SAP, and Scanning Laser Ophthalmoscopy in Glaucoma Patients Free

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Julia Lamparter; Richard A. Russell; Andreas Schulze; Ann-Christin Schuff; Norbert Pfeiffer; Esther M. Hoffmann

Tags: glaucoma, scanning laser ophthalmoscopy, perimetry

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7553-7559. doi:https://doi.org/10.1167/iovs.12-10892

Improved Reproducibility in Measuring the Laminar Thickness on Enhanced Depth Imaging SD-OCT Images Using Maximum Intensity Projection Free

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Eun Ji Lee; Tae-Woo Kim; Robert N. Weinreb

Tags: computed tomography with maximum intensity projection, cribriform plate, diagnostic imaging, optic disk, glaucoma

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7576-7582. doi:https://doi.org/10.1167/iovs.12-10305

Comparison of Single versus Multiple Injections of the Protein Saratin for Prolonging Bleb Survival in a Rabbit Model Free

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Jeff Min; Zachary L. Lukowski; Monica A. Levine; Craig A. Meyers; Ashley R. Beattie; Gregory S. Schultz; Don A. Samuelson; Mark B. Sherwood

Tags: blister, injections, oryctolagus cuniculus, proteins

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7625-7630. doi:https://doi.org/10.1167/iovs.12-10120

Posture-Induced Intraocular Pressure Changes in Eyes with Open-Angle Glaucoma, Primary Angle Closure with or without Glaucoma Medications, and Control Eyes Free

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Akira Sawada; Tetsuya Yamamoto

Tags: antiglaucoma agents, eye, glaucoma, intraocular pressure, open-angle glaucoma

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7631-7635. doi:https://doi.org/10.1167/iovs.12-10454

Relationship between Orbital Optic Nerve Axon Counts and Retinal Nerve Fiber Layer Thickness Measured by Spectral Domain Optical Coherence Tomography Free

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Grant A. Cull; Juan Reynaud; Lin Wang; George A. Cioffi; Claude F. Burgoyne; Brad Fortune

Tags: axon, eye, optic nerve, optical coherence tomography, retinal nerve fiber layer

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7766-7773. doi:https://doi.org/10.1167/iovs.12-10752

Balance Control in Glaucoma Free

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Aachal Kotecha; Greg Richardson; Reena Chopra; Rachel T. A. Fahy; David F. Garway-Heath; Gary S. Rubin

Tags: balance, device, equilibrium, glaucoma

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7795-7801. doi:https://doi.org/10.1167/iovs.12-10866

The Choroid Is Thicker in Angle Closure than in Open Angle and Control Eyes Free

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Karun S. Arora; Joan L. Jefferys; Eugenio A. Maul; Harry A. Quigley

Tags: choroid, eye, intraocular pressure, glaucoma

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7813-7818. doi:https://doi.org/10.1167/iovs.12-10483

Pulsatile Movement of the Optic Nerve Head and the Peripapillary Retina in Normal Subjects and in Glaucoma Free

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Kanwarpal Singh; Carolyne Dion; Antoine G. Godin; Faezeh Lorghaba; Denise Descovich; Marcelo Wajszilber; Tsuneyuki Ozaki; Santiago Costantino; Mark R. Lesk

Tags: glaucoma, optic disk, retina, body tissue

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7819-7824. doi:https://doi.org/10.1167/iovs.12-9834

Immunology and Microbiology

The Diabetic Ocular Environment Facilitates the Development of Endogenous Bacterial Endophthalmitis Free

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Phillip S. Coburn; Brandt J. Wiskur; Elizabeth Christy; Michelle C. Callegan

Tags: bacterial endophthalmitis, diabetes mellitus, mice, eye

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7426-7431. doi:https://doi.org/10.1167/iovs.12-10661

Effects of VIP on Corneal Reconstitution and Homeostasis following Pseudomonas aeruginosa Induced Keratitis Free

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Elizabeth A. Berger; Kerry S. Vistisen; Ronald P. Barrett; Linda D. Hazlett

Tags: cornea, fibroblasts, homeostasis, infections, keratitis

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7432-7439. doi:https://doi.org/10.1167/iovs.12-9894

The Role of VIP in Cornea Free

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Xiaoyu Jiang; Sharon A. McClellan; Ronald P. Barrett; Yunfan Zhang; Megan E. Foldenauer; Linda D. Hazlett

Tags: antagonists, cornea, infections, mice, reverse transcriptase polymerase chain reaction

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7560-7566. doi:https://doi.org/10.1167/iovs.12-10437

Interleukin-6 Production in CD40-Engaged Fibrocytes in Thyroid-Associated Ophthalmopathy: Involvement of Akt and NF-κB Free

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Erin F. Gillespie; Nupur Raychaudhuri; Konstantinos I. Papageorgiou; Stephen J. Atkins; Ying Lu; Laya K. Charara; Tünde Mester; Terry J. Smith; Raymond S. Douglas

Tags: cd40 antigens, cd40 ligand, graves' ophthalmopathy, interleukin-6, proto-oncogene proteins c-akt

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7746-7753. doi:https://doi.org/10.1167/iovs.12-9861

Keratitis-Associated Fungi Form Biofilms with Reduced Antifungal Drug Susceptibility Free

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Xiaoyan Zhang; Xuguang Sun; Zhiqun Wang; Yang Zhang; Wenbo Hou

Tags: antifungal agents, biofilms, disease susceptibility, keratitis, fungus

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7774-7778. doi:https://doi.org/10.1167/iovs.12-10810

Low Vision

Spatial Contrast Sensitivity Vision Loss in Children with Cortical Visual Impairment Free

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William V. Good; Chuan Hou; Anthony M. Norcia

Tags: blindness, child, contrast sensitivity, cortical blindness, impairment

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7730-7734. doi:https://doi.org/10.1167/iovs.12-9775

Multidisciplinary Ophthalmic Imaging

Construction of an Inexpensive, Hand-Held Fundus Camera through Modification of a Consumer “Point-and-Shoot” Camera Free

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Kenneth Tran; Thomas A. Mendel; Kristina L. Holbrook; Paul A. Yates

Tags: diagnostic imaging, eye, hand, lens (device), lens, crystalline

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7600-7607. doi:https://doi.org/10.1167/iovs.12-10449

Relationship between Retinal Layer Thickness and the Visual Field in Early Age-Related Macular Degeneration Free

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Jennifer H. Acton; R. Theodore Smith; Donald C. Hood; Vivienne C. Greenstein

Tags: age-related macular degeneration, eye, scotoma, visual fields

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7618-7624. doi:https://doi.org/10.1167/iovs.12-10361

Dynamic Contrast-Enhanced MRI for Assessing Therapeutic Response of Choroidal Neovascularization in a Rat Model Free

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Jae-Hun Kim; Geun Ho Im; Jaemoon Yoon; Jehoon Yang; Julius Juhyun Chung; Ji Hoon Cha; Sun I. Kim; Don-il Ham; Jung Hee Lee

Tags: choroidal neovascularization, dynamic contrast-enhanced magnetic resonance imaging, rats, contrast-enhanced magnetic resonance imaging, retina

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7693-7700. doi:https://doi.org/10.1167/iovs.12-9805

Retina

Automated Segmentation of the Choroid from Clinical SD-OCT Free

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Li Zhang; Kyungmoo Lee; Meindert Niemeijer; Robert F. Mullins; Milan Sonka; Michael D. Abràmoff

Tags: choroid, vasculature, volume

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7510-7519. doi:https://doi.org/10.1167/iovs.12-10311

Aligning Scan Locations from Consecutive Spectral-Domain Optical Coherence Tomography Examinations: A Comparison among Different Strategies Free

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Andrea Giani; Marco Pellegrini; Alessandro Invernizzi; Mario Cigada; Giovanni Staurenghi

Tags: edema, optical coherence tomography, eye-tracking, fovea centralis, engineering

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7637-7643. doi:https://doi.org/10.1167/iovs.12-10047

Long-Term Decline of Central Cone Function in Retinitis Pigmentosa Evaluated by Focal Electroretinogram Free

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Benedetto Falsini; Lucia Galli-Resta; Antonello Fadda; Lucia Ziccardi; Marco Piccardi; Giancarlo Iarossi; Giovanni Resta

Tags: electroretinography, retinal cone, retinitis pigmentosa, follow-up

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7701-7709. doi:https://doi.org/10.1167/iovs.12-11017

Association between Choroidal Thickness and Ocular Perfusion Pressure in Young, Healthy Subjects: Enhanced Depth Imaging Optical Coherence Tomography Study Free

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Min Kim; Sung Soo Kim; Hee Jung Kwon; Hyoung Jun Koh; Sung Chul Lee

Tags: diagnostic imaging, diopters, eye, myopia, optical coherence tomography

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7710-7717. doi:https://doi.org/10.1167/iovs.12-10464

Anti-Angiogenic Effect of Luteolin on Retinal Neovascularization via Blockade of Reactive Oxygen Species Production Free

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Sung Wook Park; Chang Sik Cho; Hyoung Oh Jun; Nam Hee Ryu; Jin Hyoung Kim; Young Suk Yu; Jin Sook Kim; Jeong Hun Kim

Tags: angiogenesis, reactive oxygen species, retinal neovascularization, vascular endothelial growth factor a, hypoxia

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7718-7726. doi:https://doi.org/10.1167/iovs.11-8790

Macular Choroidal Thickness Measured by Swept Source Optical Coherence Tomography in Eyes with Inferior Posterior Staphyloma Free

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Abdallah A. Ellabban; Akitaka Tsujikawa; Akiko Matsumoto; Kenji Yamashiro; Akio Oishi; Sotaro Ooto; Isao Nakata; Yumiko Akagi-Kurashige; Masahiro Miyake; Nagahisa Yoshimura

Tags: choroid, eye, optical coherence tomography, staphyloma

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7735-7745. doi:https://doi.org/10.1167/iovs.12-9952

Repeatability of Spectralis OCT Measurements of Macular Thickness and Volume in Diabetic Macular Edema Free

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Oliver Comyn; Ling Zhi Heng; Felicia Ikeji; Kanom Bibi; Philip G. Hykin; James W. Bainbridge; Praveen J. Patel

Tags: diabetic macular edema, volume

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7754-7759. doi:https://doi.org/10.1167/iovs.12-10895

Retinal Prosthesis Safety: Alterations in Microglia Morphology due to Thermal Damage and Retinal Implant Contact Free

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Nicholas L. Opie; Ursula Greferath; Kirstan A. Vessey; Anthony N. Burkitt; Hamish Meffin; David B. Grayden; Erica L. Fletcher

Tags: body temperature, implants, language morphology, microglia, morphology

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7802-7812. doi:https://doi.org/10.1167/iovs.12-10600

Development-Related Splicing Regulates Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Receptors in the Retina Free

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Mónika Lakk; Bence Szabó; Béla Völgyi; Róbert Gábriel; Viktória Dénes

Tags: pituitary adenylate cyclase activating polypeptide, protein isoforms, retina, rna splicing, vipr2 gene

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7825-7832. doi:https://doi.org/10.1167/iovs.12-10417

The Impact of Macular Pigment Augmentation on Visual Performance Using Different Carotenoid Formulations Free

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James Loughman; John M. Nolan; Alan N. Howard; Eithne Connolly; Katie Meagher; Stephen Beatty

Tags: carotenoids, pigment, placebos, vision, contrast sensitivity

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7871-7880. doi:https://doi.org/10.1167/iovs.12-10690

The IS/OS Junction Layer in the Natural History of Type 2 Idiopathic Macular Telangiectasia Free

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Ferenc B. Sallo; Tunde Peto; Catherine Egan; Ute E. K. Wolf-Schnurrbusch; Traci E. Clemons; Mark C. Gillies; Daniel Pauleikhoff; Gary S. Rubin; Emily Y. Chew; Alan C. Bird; the MacTel Study Group

Tags: diagnostic imaging, eye, face, natural history, telangiectasis

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7889-7895. doi:https://doi.org/10.1167/iovs.12-10765

Retinal Cell Biology

Lectin from Agaricus bisporus Inhibited S Phase Cell Population and Akt Phosphorylation in Human RPE Cells Free

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Yiu-Him Cheung; Carl M. Sheridan; Amy C. Y. Lo; Wico W. Lai

Tags: lectin, phosphorylation, proto-oncogene proteins c-akt, retinal pigment cell, s phase

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7469-7475. doi:https://doi.org/10.1167/iovs.12-10589

Upregulation of Retinal Neuronal MCP-1 in the Rodent Model of Diabetic Retinopathy and Its Function In Vitro Free

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Ning Dong; Xiaoxin Li; Lin Xiao; Wenzen Yu; Bingsong Wang; Liqun Chu

Tags: monocyte chemoattractant protein-1, neurons, microglia, diabetic retinopathy, rodentia

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7567-7575. doi:https://doi.org/10.1167/iovs.12-9446

Induction of Endoplasmic Reticulum Stress Genes, BiP and Chop, in Genetic and Environmental Models of Retinal Degeneration Free

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Heike Kroeger; Carissa Messah; Kelly Ahern; Jason Gee; Victory Joseph; Michael T. Matthes; Douglas Yasumura; Marina S. Gorbatyuk; Wei-Chieh Chiang; Matthew M. LaVail; Jonathan H. Lin

Tags: cyclophosphamide, doxorubicin, prednisone, and vincristine, retinal degeneration, stress, genes, genetics

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7590-7599. doi:https://doi.org/10.1167/iovs.12-10221

A Novel Role of Complement in Retinal Degeneration Free

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Minzhong Yu; Weilin Zou; Neal S. Peachey; Thomas M. McIntyre; Jinbo Liu

Tags: complement system proteins, mice, retinal degeneration, electroretinography

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7684-7692. doi:https://doi.org/10.1167/iovs.12-10069

Ccl2/Cx3cr1 Knockout Mice Have Inner Retinal Dysfunction but Are Not an Accelerated Model of AMD Free

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Kirstan A. Vessey; Ursula Greferath; Andrew I. Jobling; Joanna A. Phipps; Tracy Ho; Michelle Waugh; Erica L. Fletcher

Tags: language morphology, mice, monocyte chemoattractant protein-1, morphology, retina

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7833-7846. doi:https://doi.org/10.1167/iovs.12-10650

Protective Effect of Carnosic Acid, a Pro-Electrophilic Compound, in Models of Oxidative Stress and Light-Induced Retinal Degeneration Free

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Tayebeh Rezaie; Scott R. McKercher; Kunio Kosaka; Masaaki Seki; Larry Wheeler; Veena Viswanath; Teresa Chun; Rabina Joshi; Marcos Valencia; Shunsuke Sasaki; Terumasa Tozawa; Takumi Satoh; Stuart A. Lipton

Tags: antioxidants, cell lines, electroretinography, oxidative stress, photoreceptors

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7847-7854. doi:https://doi.org/10.1167/iovs.12-10793

Metallothionein-III Deficiency Exacerbates Light-Induced Retinal Degeneration Free

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Kazuhiro Tsuruma; Hiroki Shimazaki; Yuta Ohno; Yuki Inoue; Akiko Honda; Shunsuke Imai; Jinyong Lee; Masamitsu Shimazawa; Masahiko Satoh; Hideaki Hara

Tags: light exposure, metallothionein, mice, retinal degeneration, rna, small interfering

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7896-7903. doi:https://doi.org/10.1167/iovs.12-10165

Visual Neuroscience

Histamine Involvement in Visual Development and Adaptation Free

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Dimitrios P. Bessinis; Christina Dalla; Zeta Papadopoulou Daifoti; Ekaterini Tiligada

Tags: histamine

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7498-7503. doi:https://doi.org/10.1167/iovs.12-10809

Visual Psychophysics and Physiological Optics

Phosphene Thresholds Elicited by Transcorneal Electrical Stimulation in Healthy Subjects and Patients with Retinal Diseases Free

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Lubka Naycheva; Andreas Schatz; Tobias Röck; Gabriel Willmann; André Messias; Karl Ulrich Bartz-Schmidt; Eberhart Zrenner; Florian Gekeler

Tags: accommodation phosphene, electric stimulation, retinal diseases, nonarteritic anterior ischemic optic neuropathy, open-angle glaucoma

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7440-7448. doi:https://doi.org/10.1167/iovs.12-9612

Visual Acuity, Crowding, and Stereo-Vision Are Linked in Children with and without Amblyopia Free

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John A. Greenwood; Vijay K. Tailor; John J. Sloper; Anita J. Simmers; Peter J. Bex; Steven C. Dakin

Tags: amblyopia, child, crowding, vision, visual acuity

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7655-7665. doi:https://doi.org/10.1167/iovs.12-10313

Analysis of Higher-Order Aberrations in a Large Clinical Population Free

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Andreas Hartwig; David A. Atchison

Tags: anisometropia, coma, eye, refraction, astigmatism

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7862-7870. doi:https://doi.org/10.1167/iovs.12-10610

Clinical Trials

Dose-Ranging Evaluation of Intravitreal siRNA PF-04523655 for Diabetic Macular Edema (the DEGAS Study) Free

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Quan Dong Nguyen; Ronald A. Schachar; Chudy I. Nduaka; Marvin Sperling; Anthony S. Basile; Karen J. Klamerus; Katherine Chi-Burris; Eric Yan; Dario A. Paggiarino; Irit Rosenblatt; Roger Aitchison; Shai S. Erlich

Tags: diabetic macular edema, lasers, light coagulation, rna, rna, small interfering

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7666-7674. doi:https://doi.org/10.1167/iovs.12-9961

Letters to the Editor

Author Response: Axial Length Changes with Shifts of Gaze in Myopes and Emmetropes Free

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Atanu Ghosh; Michael J. Collins; Scott A. Read; Brett A. Davis

Tags: gaze

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7636. doi:https://doi.org/10.1167/iovs.12-11190

Pupil Dynamics and Response Amplitude: Only Size Matters Free

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Ted Maddess

Tags: pupil

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7644. doi:https://doi.org/10.1167/iovs.12-11105

Author Response: Different Efficacy of Propranolol in Mice with Oxygen-Induced Retinopathy: Could Differential Effects of Propranolol Be Related to Differences in Mouse Strains? Free

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Jing Chen; Ann Hellstrom; Lois E. H. Smith

Tags: mice, oxygen, propranolol, retinal diseases

Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7728-7729. doi:https://doi.org/10.1167/iovs.12-11199

Erratum

Erratum Free

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Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7654. doi:https://doi.org/10.1167/iovs.12-10721a

Erratum Free

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Investigative Ophthalmology & Visual Science November 2012, Vol.53, 7779. doi:https://doi.org/10.1167/iovs.11-8113a

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