Select a back issue
Select a back issue
  • Alerts
    User Alerts
    You are adding an alert for:
    Investigative Ophthalmology & Visual Science
    You will receive an email whenever new content is published in the Investigative Ophthalmology & Visual Science. You can manage this and all other alerts in My Account
    The alert will be sent to:
    ×
    This feature is available to authenticated users only.
    Sign In or Create an Account ×

Research Highlight

Blindness-Causing Trachomatous Trichiasis Biomarkers Sighted Free
PDF
Huizhou Fan
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2560. doi:https://doi.org/10.1167/iovs.12-9835

Anatomy and Pathology/Oncology

The Role of RASSF1A in Uveal Melanoma Free
PDF
Olga Dratviman-Storobinsky; Yoram Cohen; Shahar Frenkel; Efrat Merhavi-Shoham; Shimrit Dadon-Bar El; Natalia Binkovsky; Jacob Pe'er; Nitza Goldenberg-Cohen
Tags: cell lines, cell transplantation, methylation, mice, neoplasms
Investigative Ophthalmology & Visual Science October 2012, Vol.53, 2611-2619. doi:https://doi.org/10.1167/iovs.11-7730
A Comparison of HLA Genotype with Inflammation in Uveal Melanoma Free
PDF
T. Huibertus van Essen; Inge H. G. Bronkhorst; Willem Maat; Willem Verduyn; Dave L. Roelen; Gregorius P. M. Luyten; Martine J. Jager
Tags: human leukocyte antigens, uveal melanoma, inflammation, alleles, genotype
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2640-2646. doi:https://doi.org/10.1167/iovs.11-8901
Comparison of Formalin-Fixed and Snap-Frozen Samples Analyzed by Multiplex Ligation-Dependent Probe Amplification for Prognostic Testing in Uveal Melanoma Free
PDF
Sarah L. Lake; Helen Kalirai; Justyna Dopierała; Bertil E. Damato; Sarah E. Coupland
Tags: amplification, dna, formaldehyde, ligation, sensory potential
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2647-2652. doi:https://doi.org/10.1167/iovs.12-9584
Modeling Human Choroidal Melanoma Xenograft Growth in Immunocompromised Rodents to Assess Treatment Efficacy Free
PDF
Rod D. Braun; Kerry S. Vistisen
Tags: malignant melanoma of choroid, neoplasms, transplantation, heterologous, treatment effectiveness, tumor growth
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2693-2701. doi:https://doi.org/10.1167/iovs.11-9265

Biochemistry and Molecular Biology

Enhancement of rAAV2-Mediated Transgene Expression in Retina Cells In Vitro and In Vivo by Coadministration of Low-Dose Chemotherapeutic Drugs Free
PDF
Shenghai Zhang; Jihong Wu; Xiaobing Wu; Ping Xu; Yuhua Tian; Miaoying Yi; Xinjian Liu; Xiaoyan Dong; Frank Wolf; Chuanyuan Li; Qian Huang
Tags: antineoplastic agents, infections, retina, transgenes
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2675-2684. doi:https://doi.org/10.1167/iovs.11-8856
Retinoid Content, Visual Responses, and Ocular Morphology Are Compromised in the Retinas of Mice Lacking the Retinol-Binding Protein Receptor, STRA6 Free
PDF
Alberto Ruiz; Manuel Mark; Hugues Jacobs; Muriel Klopfenstein; Jane Hu; Marcia Lloyd; Samer Habib; Chinatsu Tosha; Roxana A Radu; Norbert B Ghyselinck; Steven Nusinowitz; Dean Bok
Tags: mice, retina, retinoids, vitamin a, eye
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3027-3039. doi:https://doi.org/10.1167/iovs.11-8476
Phosphorylation of Phosducin Accelerates Rod Recovery from Transducin Translocation Free
PDF
Marycharmain Belcastro; Hongman Song; Satyabrata Sinha; Chunyan Song; Peter H Mathers; Maxim Sokolov
Tags: mice, phosphorylation, recovery of function, rod photoreceptors, transducin
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3084-3091. doi:https://doi.org/10.1167/iovs.11-8798

Clinical and Epidemiologic Research

Prevalence of Asymptomatic and Symptomatic Meibomian Gland Dysfunction in the General Population of Spain Free
PDF
Eloy Viso; María Teresa Rodríguez-Ares; Dolores Abelenda; Benjamín Oubiña; Francisco Gude
Tags: meibomian gland, pathophysiology, prevalence, signs and symptoms, spain
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2601-2606. doi:https://doi.org/10.1167/iovs.11-9228
Increased Mortality Risk among the Visually Impaired: The Roles of Mental Well-Being and Preventive Care Practices Free
PDF
D. Diane Zheng; Sharon L. Christ; Byron L. Lam; Kristopher L. Arheart; Anat Galor; David J. Lee
Tags: mortality, personal satisfaction, preventive health services, visual impairment
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2685-2692. doi:https://doi.org/10.1167/iovs.11-8794
Time Outdoors and Physical Activity as Predictors of Incident Myopia in Childhood: A Prospective Cohort Study Free
PDF
Jeremy A. Guggenheim; Kate Northstone; George McMahon; Andy R. Ness; Kevin Deere; Calum Mattocks; Beate St Pourcain; Cathy Williams
Tags: child, myopia, physical activity, prospective studies
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2856-2865. doi:https://doi.org/10.1167/iovs.11-9091
Inter-Examiner Reliability in Meibomian Gland Dysfunction Assessment Free
PDF
Daniel R. Powell; Jason J. Nichols; Kelly K Nichols
Tags: meibomian gland, pathophysiology, reliability, telangiectasis, slit lamps
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3120-3125. doi:https://doi.org/10.1167/iovs.12-9600
Meta-Analysis of Sex Differences in Presbyopia Free
PDF
Adam Hickenbotham; Austin Roorda; Craig Steinmaus; Adrian Glasser
Tags: meta-analysis, presbyopia, sex characteristics
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3215-3220. doi:https://doi.org/10.1167/iovs.12-9791
The Prevalence of Glaucoma in Adult Rural Chinese Populations of the Bai Nationality in Dali: The Yunnan Minority Eye Study Free
PDF
Hua Zhong; Jun Li; Cairui Li; Tao Wei; Xueping Cha; Ning Cai; Tinghao Luo; Minbin Yu; Yuansheng Yuan
Tags: adult, chinese people, eye, glaucoma, prevalence
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3221-3225. doi:https://doi.org/10.1167/iovs.11-9306

Cornea

Manual Suction versus Femtosecond Laser Trephination for Penetrating Keratoplasty: Intraocular Pressure, Endothelial Cell Damage, Incision Geometry, and Wound Healing Responses Free
PDF
Romesh I. Angunawela; Andri Riau; Shyam S. Chaurasia; Donald T. Tan; Jodhbir S. Mehta
Tags: cornea, endothelial cells, femtosecond pulsed lasers, intraocular pressure, suction drainage
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2571-2579. doi:https://doi.org/10.1167/iovs.11-8403
Reliability and Reproducibility of Assessment of Corneal Epithelial Thickness by Fourier Domain Optical Coherence Tomography Free
PDF
Gaurav Prakash; Amar Agarwal; Anjum Iqbal Mazhari; Mathangi Chari; Dhivya Ashok Kumar; Gautam Kumar; Bunty Singh
Tags: cornea, epithelium, optical coherence tomography, reliability
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2580-2585. doi:https://doi.org/10.1167/iovs.11-8981
Effect of the Synthetic NC-1059 Peptide on Diffusion of Riboflavin across an Intact Corneal Epithelium Free
PDF
Yuntao Zhang; Pinakin Sukthankar; John M. Tomich; Gary W. Conrad
Tags: cornea, corneal epithelium, diffusion, peptides, riboflavin
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2620-2629. doi:https://doi.org/10.1167/iovs.12-9537
Isolation and Characterization of Progenitor Cells in Uninjured, Adult Rat Lacrimal Gland Free
PDF
Marie A. Shatos; Linda Haugaard-Kedstrom; Robin R. Hodges; Darlene A. Dartt
Tags: adult, lacrimal gland, patient isolation, social isolation, stem cells
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2749-2759. doi:https://doi.org/10.1167/iovs.11-9025
Quantitative Assessment of Ultrastructure and Light Scatter in Mouse Corneal Debridement Wounds Free
PDF
Craig Boote; Yiqin Du; Sian Morgan; Jonathan Harris; Christina S. Kamma-Lorger; Sally Hayes; Kira L. Lathrop; Danny S. Roh; Michael K. Burrow; Jennifer Hiller; Nicholas J. Terrill; James L. Funderburgh; Keith M. Meek
Tags: cornea, debridement, mice, wounds and injuries, diagnostic radiologic examination
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2786-2795. doi:https://doi.org/10.1167/iovs.11-9305
Effect of Biopsy Location and Size on Proliferative Capacity of Ex Vivo Expanded Conjunctival Tissue Free
PDF
Jon R. Eidet; Ida G. Fostad; Marie A. Shatos; Tor P. Utheim; Øygunn A. Utheim; Sten Raeder; Darlene A. Dartt
Tags: biopsy, body tissue, conjunctiva, phenotype
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2897-2903. doi:https://doi.org/10.1167/iovs.11-8269
Evaluation of Total and Corneal Wavefront High Order Aberrations for the Detection of Forme Fruste Keratoconus Free
PDF
Alain Saad; Damien Gatinel
Tags: cornea, keratoconus, coma
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2978-2992. doi:https://doi.org/10.1167/iovs.11-8803
Role of Histamine and Its Receptor Subtypes in Stimulation of Conjunctival Goblet Cell Secretion Free
PDF
Densen Hayashi; Dayu Li; Chisato Hayashi; Marie Shatos; Robin R. Hodges; Darlene A. Dartt
Tags: bodily secretions, conjunctiva, goblet cells, histamine, histamine receptors
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2993-3003. doi:https://doi.org/10.1167/iovs.11-8748
The Maintenance of Lymphatic Vessels in the Cornea Is Dependent on the Presence of Macrophages Free
PDF
Kazuichi Maruyama; Toru Nakazawa; Claus Cursiefen; Yuko Maruyama; Nico Van Rooijen; Patricia A. D'Amore; Shigeru Kinoshita
Tags: cornea, lymphatic vessels, macrophage-1 antigen, mice, mice, inbred c57bl
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3145-3153. doi:https://doi.org/10.1167/iovs.11-8010
Characterization by Belmonte's Gas Esthesiometer of Mechanical, Chemical, and Thermal Corneal Sensitivity Thresholds in a Normal Population Free
PDF
Marisa Tesón; Margarita Calonge; Itziar Fernández; Michael E. Stern; María J. González-García
Tags: cornea, eye, common cold
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3154-3160. doi:https://doi.org/10.1167/iovs.11-9304
Overexpression of Human HMW FGF-2 but Not LMW FGF-2 Reduces the Cytotoxic Effect of Lentiviral Gene Transfer in Human Corneal Endothelial Cells Free
PDF
Monika Valtink; Lilla Knels; Nicole Stanke; Katrin Engelmann; Richard H. W. Funk; Dirk Lindemann
Tags: cytotoxicity, fibroblast growth factor 2, gene transfer techniques, protein isoforms, cornea
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3207-3214. doi:https://doi.org/10.1167/iovs.12-9423
Spontaneous Episodic Decreased Tear Secretion in Rats Is Related to Opioidergic Signaling Pathways Free
PDF
Ian S. Zagon; Anna M. Campbell; Joseph W. Sassani; Patricia J. McLaughlin
Tags: bodily secretions, opioid analgesics, opioids, rats, signal pathway
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3234-3240. doi:https://doi.org/10.1167/iovs.11-9051
Demodex-Associated Bacillus Proteins Induce an Aberrant Wound Healing Response in a Corneal Epithelial Cell Line: Possible Implications for Corneal Ulcer Formation in Ocular Rosacea Free
PDF
Niamh O'Reilly; Clair Gallagher; Kishore Reddy Katikireddy; Martin Clynes; Finbarr O'Sullivan; Kevin Kavanagh
Tags: bacillus, proteins, corneal epithelial cells, ocular rosacea, cornea
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3250-3259. doi:https://doi.org/10.1167/iovs.11-9295
KLEIP Deficiency in Mice Causes Progressive Corneal Neovascular Dystrophy Free
PDF
Nicole Hahn; Christian T. Dietz; Sandra Kühl; Urs Vossmerbaeumer; Jens Kroll
Tags: cornea, mice, hereditary corneal dystrophy
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3260-3268. doi:https://doi.org/10.1167/iovs.12-9676

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Evaluation of the Adult Strabismus-20 (AS-20) Questionnaire Using Rasch Analysis Free
PDF
David A. Leske; Sarah R. Hatt; Laura Liebermann; Jonathan M. Holmes
Tags: adult, questionnaires, rasch model, reading (activity), strabismus
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2630-2639. doi:https://doi.org/10.1167/iovs.11-8308
Differential Lateral Rectus Compartmental Contraction during Ocular Counter-Rolling Free
PDF
Robert A. Clark; Joseph L. Demer
Tags: eye, gaze, lateral rectus muscle, magnetic resonance imaging, orbit
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2887-2896. doi:https://doi.org/10.1167/iovs.11-7929

Genetics

Higher Percentage of FISH-Determined Monosomy 3 and 8q Amplification in Uveal Melanoma Cells relate to Poor Patient Prognosis Free
PDF
Thomas van den Bosch; Jackelien G. M. van Beek; Jolanda Vaarwater; Robert M. Verdijk; Nicole C. Naus; Dion Paridaens; Annelies de Klein; Emine Kiliç
Tags: amplification, chromosomes, monosomy, neoplasms, uveal melanoma
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2668-2674. doi:https://doi.org/10.1167/iovs.11-8697
MicroRNA-328 May Influence Myopia Development by Mediating the PAX6 Gene Free
PDF
Ku-Chung Chen; Edward Hsi; Ching-Yu Hu; Wen-Wen Chou; Chung-Ling Liang; Suh-Hang Hank Juo
Tags: genes, micrornas, myopia, retinal pigment cell, sclera
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2732-2739. doi:https://doi.org/10.1167/iovs.11-9272
Recessive Mutations in TSPAN12 Cause Retinal Dysplasia and Severe Familial Exudative Vitreoretinopathy (FEVR) Free
PDF
James A. Poulter; Alice E. Davidson; Manir Ali; David F. Gilmour; David A. Parry; Helen A. Mintz-Hittner; Ian M. Carr; Helen M. Bottomley; Vernon W. Long; Louise M. Downey; Panagiotis I. Sergouniotis; Genevieve A. Wright; Robert E. MacLaren; Anthony T. Moore; Andrew R. Webster; Chris F. Inglehearn; Carmel Toomes
Tags: familial exudative vitreoretinopathies, mutation, retinal dysplasia, family
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2873-2879. doi:https://doi.org/10.1167/iovs.11-8629
Differentiation of Exudative Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in the ARMS2/HTRA1 Locus Free
PDF
Xiao Ying Liang; Timothy Y. Y. Lai; David T. L. Liu; Alex H. Fan; Li Jia Chen; Pancy O. S. Tam; Sylvia W. Y. Chiang; Tsz Kin Ng; Dennis S. C. Lam; Chi Pui Pang
Tags: exudative age-related macular degeneration, htra1 gene, vascular diseases, single nucleotide polymorphism
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3175-3182. doi:https://doi.org/10.1167/iovs.11-8135

Glaucoma

Factors Associated with Anterior Chamber Narrowing with Age: An Optical Coherence Tomography Study Free
PDF
Jae Hong Sun; Kyung Rim Sung; Sung-Cheol Yun; Mi Hyun Cheon; Hung Won Tchah; Myoung Joon Kim; Jae Yong Kim
Tags: anterior chamber of eye, immune reconstitution inflammatory syndrome, optical coherence tomography, lens, crystalline, iris
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2607-2610. doi:https://doi.org/10.1167/iovs.11-9359
The Optic Nerve Head as a Robust Biomechanical System Free
PDF
Ian A. Sigal; Richard A. Bilonick; Larry Kagemann; Gadi Wollstein; Hiroshi Ishikawa; Joel S. Schuman; Jonathan L. Grimm
Tags: intraocular pressure, optic disk, stress, eye, mass or substance concentration per volume
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2658-2667. doi:https://doi.org/10.1167/iovs.11-9303
A Validated Risk Calculator to Assess Risk and Rate of Visual Field Progression in Treated Glaucoma Patients Free
PDF
Carlos Gustavo De Moraes; Mitra Sehi; David S. Greenfield; Yun S. Chung; Robert Ritch; Jeffrey M. Liebmann
Tags: glaucoma, risk assessment, visual fields
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2702-2707. doi:https://doi.org/10.1167/iovs.11-7900
Structure–Function Relationships between Spectral-Domain OCT and Standard Achromatic Perimetry Free
PDF
Naveed Nilforushan; Nariman Nassiri; Sasan Moghimi; Simon K. Law; JoAnn Giaconi; Anne L. Coleman; Joseph Caprioli; Kouros Nouri-Mahdavi
Tags: glaucoma, perimetry, retinal nerve fiber layer, visual fields, eye
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2740-2748. doi:https://doi.org/10.1167/iovs.11-8320
Improved Estimates of Visual Field Progression Using Bayesian Linear Regression to Integrate Structural Information in Patients with Ocular Hypertension Free
PDF
Richard A. Russell; Rizwan Malik; Balwantray C. Chauhan; David P. Crabb; David F. Garway-Heath
Tags: linear regression, ocular hypertension, visual fields, glaucoma
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2760-2769. doi:https://doi.org/10.1167/iovs.11-7976
Intervals between Visual Field Tests When Monitoring the Glaucomatous Patient: Wait-and-See Approach Free
PDF
David P. Crabb; David F. Garway-Heath
Tags: follow-up, glaucoma, visual field testing
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2770-2776. doi:https://doi.org/10.1167/iovs.12-9476
Fluorescent Protein–Labeled Glucocorticoid Receptor alpha Isoform Trafficking in Cultured Human Trabecular Meshwork Cells Free
PDF
Adnan Dibas; Ming Jiang; Rafal Fudala; Ignacy Gryczynski; Zygmunt Gryczynski; Abbot F. Clark; Thomas Yorio
Tags: cell nucleus, cytoskeleton, glucocorticoid receptors, hsp90 heat-shock proteins, nuclear translocation
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2938-2950. doi:https://doi.org/10.1167/iovs.11-8331
Automated Quantification of Optic Nerve Axons in Primate Glaucomatous and Normal Eyes—Method and Comparison to Semi-Automated Manual Quantification Free
PDF
Juan Reynaud; Grant Cull; Lin Wang; Brad Fortune; Stuart Gardiner; Claude F Burgoyne; George A Cioffi
Tags: axon, calibration, eye, glaucoma, optic nerve
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2951-2959. doi:https://doi.org/10.1167/iovs.11-9274
Evaluation of Lamina Cribrosa and Peripapillary Sclera Stiffness in Pseudoexfoliation and Normal Eyes by Atomic Force Microscopy Free
PDF
Christoph Braunsmann; Christian M. Hammer; Johannes Rheinlaender; Friedrich E. Kruse; Tilman E. Schäffer; Ursula Schlötzer-Schrehardt
Tags: body tissue, cribriform plate, eye, microscopy, atomic force, sclera
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2960-2967. doi:https://doi.org/10.1167/iovs.11-8409
Relationship among Visual Field, Blood Flow, and Neural Structure Measurements in Glaucoma Free
PDF
John C Hwang; Ranjith Konduru; Xinbo Zhang; Ou Tan; Brian A Francis; Rohit Varma; Mitra Sehi; David S Greenfield; SriniVas R Sadda; David Huang
Tags: glaucoma, vascular flow, visual fields, blindness, optical coherence tomography
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3020-3026. doi:https://doi.org/10.1167/iovs.11-8552
The Effect of Rho-Associated Protein Kinase Inhibitor on Monkey Schlemm's Canal Endothelial Cells Free
Takanori Kameda; Toshihiro Inoue; Masaru Inatani; Tomokazu Fujimoto; Megumi Honjo; Nanako Kasaoka; Miyuki Inoue-Mochita; Nagahisa Yoshimura; Hidenobu Tanihara
Tags: actins, calcium, calcium ions, cercopithecidae, endothelial cells
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3092-3103. doi:https://doi.org/10.1167/iovs.11-8018
Ethnic Difference of the Anterior Chamber Area and Volume and Its Association with Angle Width Free
PDF
Dandan Wang; Meng Qi; Mingguang He; Lingling Wu; Shan Lin
Tags: anterior chamber of eye, chinese (other dialects), chinese people, ethnic differences, european continental ancestry group
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3139-3144. doi:https://doi.org/10.1167/iovs.12-9776
Agreement of Retinal Nerve Fiber Layer Color Codes between Stratus and Cirrus OCT according to Glaucoma Severity Free
PDF
Chan Yun Kim; Ji Won Jung; So Yeon Lee; Na Rae Kim
Tags: color, glaucoma, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3193-3200. doi:https://doi.org/10.1167/iovs.12-9440

Immunology and Microbiology

Genome-Wide Identification of Chlamydia trachomatis Antigens Associated with Trachomatous Trichiasis Free
PDF
Chunxue Lu; Martin J. Holland; Siqi Gong; Bo Peng; Robin L. Bailey; David W. Mabey; Yimou Wu; Guangming Zhong
Tags: antibodies, antigens, chlamydia trachomatis, eyelid trichiasis, genome
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2551-2559. doi:https://doi.org/10.1167/iovs.11-9212
Analysis of Human Adenovirus Type 19 Associated with Epidemic Keratoconjunctivitis and its Reclassification as Adenovirus Type 64 Free
PDF
Xiaohong Zhou; Christopher M. Robinson; Jaya Rajaiya; Shoaleh Dehghan; Donald Seto; Morris S. Jones; David W. Dyer; James Chodosh
Tags: adenovirus infections, adenoviruses, adenoviruses, human, cornea, genes
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2804-2811. doi:https://doi.org/10.1167/iovs.12-9656
Isoforms of Secretory Group Two Phospholipase A (sPLA2) in Mouse Ocular Surface Epithelia and Lacrimal Glands Free
PDF
Yi Wei; Alexander Pinhas; Ying Liu; Seth Epstein; Ju Wang; Penny Asbell
Tags: mice, protein isoforms, secretory phospholipase a2, inflammation
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2845-2855. doi:https://doi.org/10.1167/iovs.11-8684
A One-Step Multiplex PCR for Acanthamoeba Keratitis Diagnosis and Quality Samples Control Free
PDF
Danièle Maubon; Muriel Dubosson; Christophe Chiquet; Hélène Yera; Marie-Pierre Brenier-Pinchart; Muriel Cornet; Olivier Savy; Elisabeth Renard; Hervé Pelloux
Tags: dna, polymerase chain reaction, acanthamoeba keratitis, acanthamoeba
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2866-2872. doi:https://doi.org/10.1167/iovs.11-8587
The Rd8 Mutation of the Crb1 Gene Is Present in Vendor Lines of C57BL/6N Mice and Embryonic Stem Cells, and Confounds Ocular Induced Mutant Phenotypes Free
PDF
Mary J. Mattapallil; Eric F. Wawrousek; Chi-Chao Chan; Hui Zhao; Jayeeta Roychoudhury; Thomas A. Ferguson; Rachel R. Caspi
Tags: embryonic stem cells, genes, mice, mice, inbred c57bl, mutation
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2921-2927. doi:https://doi.org/10.1167/iovs.12-9662
A Model of Corneal Graft Rejection in Semi-Inbred NIH Miniature Swine: Significant T-Cell Infiltration of Clinically Accepted Allografts Free
PDF
Susan M. Nicholls; Louisa K. Mitchard; Georgina M. Laycock; Ross Harley; Jo C. Murrell; Andrew D. Dick; Michael Bailey
Tags: allografting, cornea, keratoplasty, rejection (psychology), swine, miniature
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3183-3192. doi:https://doi.org/10.1167/iovs.11-9106

Lens

Oligomerization with wt αA- and αB-Crystallins Reduces Proteasome-Mediated Degradation of C-Terminally Truncated αA-Crystallin Free
PDF
Mingxing Wu; Xinyu Zhang; Qingning Bian; Allen Taylor; Jack J. Liang; Linlin Ding; Joseph Horwitz; Fu Shang
Tags: catabolism, crystallins
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2541-2550. doi:https://doi.org/10.1167/iovs.11-9147
Integrin-Linked Kinase Deletion in the Developing Lens Leads to Capsule Rupture, Impaired Fiber Migration and Non-Apoptotic Epithelial Cell Death Free
PDF
Laura Cammas; Jordan Wolfe; Sue-Yeon Choi; Shoukat Dedhar; Hilary E Beggs
Tags: epithelial cells, epithelium, lens (device), lens, crystalline, rupture
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3067-3081. doi:https://doi.org/10.1167/iovs.11-9128
Clinical Evaluation of Optical Quality and Intraocular Scattering after Posterior Chamber Phakic Intraocular Lens Implantation Free
PDF
Kazutaka Kamiya; Kimiya Shimizu; Akihito Igarashi; Hidenaga Kobashi; Rie Ishii; Nobuyuki Sato
Tags: implantation procedure, intraocular lens implantation procedure, optics, eye, surgical procedures, operative
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3161-3166. doi:https://doi.org/10.1167/iovs.12-9650

Low Vision

Even Moderate Visual Impairments Degrade Drivers' Ability to See Pedestrians at Night Free
PDF
Joanne M. Wood; Richard A. Tyrrell; Alex Chaparro; Ralph P. Marszalek; Trent P. Carberry; Byoung Sun Chu
Tags: cataract, night time, pedestrian, visual impairment, glare
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2586-2592. doi:https://doi.org/10.1167/iovs.11-9083
Are Normally Sighted, Visually Impaired, and Blind Pedestrians Accurate and Reliable at Making Street Crossing Decisions? Free
PDF
Shirin E. Hassan
Tags: decision making, pedestrian, reliability, safety, vision
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2593-2600. doi:https://doi.org/10.1167/iovs.11-9340
The Effect of Central Visual Impairment on Manual Prehension When Tasked with Transporting-to-Place an Object Accurately to a New Location Free
PDF
Matthew A. Timmis; Shahina Pardhan
Tags: emmetropia, velocity, visual impairment, deceleration time slope
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2812-2822. doi:https://doi.org/10.1167/iovs.11-8860
Association of Vision Loss in Glaucoma and Age-Related Macular Degeneration with IADL Disability Free
PDF
Chad Hochberg; Eugenio Maul; Emilie S. Chan; Suzanne Van Landingham; Luigi Ferrucci; David S. Friedman; Pradeep Y. Ramulu
Tags: age-related macular degeneration, blindness, disability, glaucoma, instrumental activities of daily living
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3201-3206. doi:https://doi.org/10.1167/iovs.12-9469

Multidisciplinary Ophthalmic Imaging

Differential Optical Density of Subretinal Spaces Free
PDF
Meira Neudorfer; Amit Weinberg; Anat Loewenstein; Adiel Barak
Tags: optics, radiation recall dermatitis, vitreous body, retinal nerve fiber layer, retinal diseases
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3104-3110. doi:https://doi.org/10.1167/iovs.11-8700

Nantotechnology and Regenerative Medicine

Nanoparticle-Mediated Delivery of shRNA.VEGF-A Plasmids Regresses Corneal Neovascularization Free
PDF
Yureeda Qazi; Brian Stagg; Nirbhai Singh; Swita Singh; Xiaohui Zhang; Ling Luo; Jacquelyn Simonis; Uday B. Kompella; Balamurali K. Ambati
Tags: cornea, corneal neovascularization, nanoparticles, plasmids, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2837-2844. doi:https://doi.org/10.1167/iovs.11-9139
Müller Cell Expression of Genes Implicated in Proliferative Vitreoretinopathy Is Influenced by Substrate Elastic Modulus Free
PDF
Joshua T Davis; Qi Wen; Paul A Janmey; Deborah C Otteson; William J Foster
Tags: genes, vitreoretinopathy, proliferative, connective tissue growth factor, laminin
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3014-3019. doi:https://doi.org/10.1167/iovs.11-8450

Physiology and Pharmacology

Eye Vessel Compliance as a Function of Intraocular and Arterial Pressure and Eye Compliance Free
PDF
Adan Villamarin; Sylvain Roy; Nikolaos Stergiopulos
Tags: arterial pressure, eye, intraocular pressure
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2831-2836. doi:https://doi.org/10.1167/iovs.11-8752
Constriction of Retinal Arterioles to Endothelin-1: Requisite Role of Rho Kinase Independent of Protein Kinase C and L-Type Calcium Channels Free
PDF
Luke B. Potts; Yi Ren; Guangrong Lu; Enoch Kuo; Ellen Ngo; Lih Kuo; Travis W. Hein
Tags: arteriole, constriction procedure, endothelin-1, phosphotransferases, protein kinase c
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2904-2912. doi:https://doi.org/10.1167/iovs.12-9542
Feedback via Ca2+-Activated Ion Channels Modulates Endothelin 1 Signaling in Retinal Arteriolar Smooth Muscle Free
PDF
Michael Stewart; Maurice Needham; Peter Bankhead; Tom A Gardiner; C. Norman Scholfield; Tim M Curtis; J. Graham McGeown
Tags: arteriole, endothelin-1, feedback, ion channels, signal transduction
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3059-3066. doi:https://doi.org/10.1167/iovs.11-9192
Anti-Angiogenic Effect of KR-31831 on Corneal and Choroidal Neovascularization in Rat Models Free
PDF
In-Tae Kim; Hae-Young Lopilly Park; Jun-Sub Choi; Choun-Ki Joo
Tags: angiogenesis, bevacizumab, choroidal neovascularization, cornea, corneal neovascularization
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3111-3119. doi:https://doi.org/10.1167/iovs.11-8499

Retina

Nanoscale Topographic and Biomechanical Studies of the Human Internal Limiting Membrane Free
PDF
Paul B. Henrich; Christophe A. Monnier; Willi Halfter; Christos Haritoglou; Rupert W. Strauss; Roderick Y. H. Lim; Marko Loparic
Tags: fovea centralis, tissue membrane, retina, eye, vitreous body
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 2561-2570. doi:https://doi.org/10.1167/iovs.11-8502
In Vitro Biocompatibility of Various Polymer-Based Microelectrode Arrays for Retinal Prosthesis Free
PDF
So Hyun Bae; Jeong-Hwan Che; Jong-Mo Seo; Joonsoo Jeong; Eui Tae Kim; Seung Woo Lee; Kyo-in Koo; Gregg J. Suaning; Nigel H. Lovell; Dong-Il “Dan” Cho; Sung June Kim; Hum Chung
Tags: biocompatibility, cytotoxicity, microelectrodes, polymers, visual prosthesis
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2653-2657. doi:https://doi.org/10.1167/iovs.11-9341
Early Neurodegeneration in the Retina of Type 2 Diabetic Patients Free
PDF
Hille W. van Dijk; Frank D. Verbraak; Pauline H. B. Kok; Marilette Stehouwer; Mona K. Garvin; Milan Sonka; J. Hans DeVries; Reinier O. Schlingemann; Michael D. Abràmoff
Tags: diabetes mellitus, diabetes mellitus, type 2, nerve degeneration, retina, hemoglobin a, glycosylated
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2715-2719. doi:https://doi.org/10.1167/iovs.11-8997
Temporal Properties of Visual Perception on Electrical Stimulation of the Retina Free
PDF
Angélica Pérez Fornos; Jörg Sommerhalder; Lyndon da Cruz; Jose Alain Sahel; Saddek Mohand-Said; Farhad Hafezi; Marco Pelizzone
Tags: electric stimulation, joystick, perception, retina, visual perception
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2720-2731. doi:https://doi.org/10.1167/iovs.11-9344
Cell Swelling Contributes to Thickening of Low-Dose N-methyl-D-Aspartate–Induced Retinal Edema Free
PDF
Junjie Chen; Chia-Wen Chiang; Huiying Zhang; Sheng-Kwei Song
Tags: edema, n-methylaspartate, retina, magnetic resonance imaging, mice
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2777-2785. doi:https://doi.org/10.1167/iovs.11-8827
Functional Topography of Rod and Cone Photoreceptors in Macaque Retina Determined by Retinal Densitometry Free
PDF
Gen Hanazono; Kazushige Tsunoda; Yoko Kazato; Wataru Suzuki; Manabu Tanifuji
Tags: densitometry, macaca, retina, retinal cone, rod photoreceptors
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2796-2803. doi:https://doi.org/10.1167/iovs.11-9252
Fenofibrate, an Anti-Dyslipidemia Drug, Elicits the Dilation of Isolated Porcine Retinal Arterioles: Role of Nitric Oxide and AMP-Activated Protein Kinase Free
PDF
Tsuneaki Omae; Taiji Nagaoka; Ichiro Tanano; Takayuki Kamiya; Akitoshi Yoshida
Tags: arteriole, dilatation, pathologic, fenofibrate, protein kinase, nitric oxide
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2880-2886. doi:https://doi.org/10.1167/iovs.11-8841
Propranolol Inhibition of β-Adrenergic Receptor Does Not Suppress Pathologic Neovascularization in Oxygen-Induced Retinopathy Free
PDF
Jing Chen; Jean-Sebastian Joyal; Colman J. Hatton; Aimee M. Juan; Dorothy T. Pei; Christian G. Hurst; Dan Xu; Andreas Stahl; Ann Hellstrom; Lois E. H. Smith
Tags: neovascularization, pathologic, propranolol, retinal diseases, oxygen
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2968-2977. doi:https://doi.org/10.1167/iovs.12-9691
Neurodegenerative Differences in the Retinas of Male and Female Patients with Type 2 Diabetes Free
PDF
Glen Y Ozawa; Marcus A Bearse, Jr; Kevin W Bronson-Castain; Wendy W Harrison; Marilyn E Schneck; Shirin Barez; Anthony J Adams
Tags: diabetes mellitus, diabetes mellitus, type 2, eye, retina
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3040-3046. doi:https://doi.org/10.1167/iovs.11-8226
Aquaporin Changes during Diabetic Retinopathy in Rats Are Accelerated by Systemic Hypertension and Are Linked to the Renin-Angiotensin System Free
PDF
Yaowu Qin; Hui Ren; Matthew R Hoffman; Jiawen Fan; Meng Zhang; Gezhi Xu
Tags: aquaporin 1, diabetes mellitus, diabetic retinopathy, hypertension, rats
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3047-3053. doi:https://doi.org/10.1167/iovs.11-9154
Visual Function and Vision-Related Quality of Life after Vitrectomy for Epiretinal Membranes: A 12-Month Follow-up Study Free
PDF
Yotaro Matsuoka; Masaki Tanito; Yasuyuki Takai; Yasurou Koyama; Shin Nonoyama; Akihiro Ohira
Tags: epiretinal membrane, follow-up studies, quality of life, vision, vitrectomy
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3054-3058. doi:https://doi.org/10.1167/iovs.11-9153
Spectral-Domain Optical Coherence Tomography as a Noninvasive Method to Assess Damaged and Regenerating Adult Zebrafish Retinas Free
PDF
Travis J. Bailey; Darin H. Davis; Joseph E. Vance; David R. Hyde
Tags: adult, retina, zebrafish, optical coherence tomography, ouabain
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3126-3138. doi:https://doi.org/10.1167/iovs.11-8895
Attenuated Glial Reaction in Experimental Proliferative Vitreoretinopathy Treated with Liposomal Doxorubicin Free
PDF
Hsi-Kung Kuo; Yi-Hao Chen; Pei-Chang Wu; Yi-Chen Wu; Faye Huang; Chun-Wei Kuo; Li-Hua Lo; Jentaie Shiea
Tags: attenuation, doxorubicin, eye, hmga2 protein, lipoma
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3167-3174. doi:https://doi.org/10.1167/iovs.11-7972
Endoplasmic Reticulum Stress in Retinal Vascular Degeneration: Protective Role of Resveratrol Free
PDF
Chuanzhou Li; Leilei Wang; Kun Huang; Ling Zheng
Tags: resveratrol, stress, tissue degeneration, tunicamycin
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3241-3249. doi:https://doi.org/10.1167/iovs.11-8406

Retinal Cell Biology

Neuronal NAD(P)H Oxidases Contribute to ROS Production and Mediate RGC Death after Ischemia Free
PDF
Galina Dvoriantchikova; Jeff Grant; Andrea Rachelle C. Santos; Eleut Hernandez; Dmitry Ivanov
Tags: ischemia, oxidase, oxygen, glucose
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2823-2830. doi:https://doi.org/10.1167/iovs.12-9526
Compound 49b Prevents Diabetes-Induced Apoptosis through Increased IGFBP-3 Levels Free
PDF
Qiuhua Zhang; Kimberly Guy; Jayaprakash Pagadala; Youde Jiang; Robert J Walker; Luhong Liu; Carl Soderland; Timothy S Kern; Robert Ferry, Jr; Hui He; C. Ryan Yates; Duane D Miller; Jena J Steinle
Tags: apoptosis, diabetes mellitus, diabetic retinopathy, insulin-like growth factor binding protein 3, glucose
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3004-3013. doi:https://doi.org/10.1167/iovs.11-8779

Translational

Assessment of 180° Rotation of the Choroid as a Novel Surgical Treatment for Age-Related Macular Degeneration Free
PDF
Edward Lee; Mandeep S. Singh; Helen E. Jones; Bashir Ahmed; Ian M. Andolina; Jake T. C. Clements; Vy Luong; Peter M. Munro; Martin P. Lawton; Kenneth L. Grieve; George W. Aylward; Adam M. Sillito; Robert E. MacLaren
Tags: age-related macular degeneration, choroid, surgical procedures, operative, tissue transplants, retina
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2523-2532. doi:https://doi.org/10.1167/iovs.11-8674
Laser-Mediated Activation of Human Retinal Pigment Epithelial Cells and Concomitant Release of Matrix Metalloproteinases Free
PDF
Jin Jun Zhang; Yue Sun; Ali A. Hussain; John Marshall
Tags: laser therapy, lasers, matrix metalloproteinases, retinal pigment cell
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2928-2937. doi:https://doi.org/10.1167/iovs.11-8585

Visual Neuroscience

Quantification of Visual Orienting Responses to Coherent Form and Motion in Typically Developing Children Aged 0–12 Years Free
PDF
Fleur H. Boot; Johan J. M. Pel; Heleen M. Evenhuis; Johannes van der Steen
Tags: child, child development, motion, reaction time
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2708-2714. doi:https://doi.org/10.1167/iovs.11-8893

Visual Psychophysics and Physiological Optics

Methods to Estimate the Size and Shape of the Unaccommodated Crystalline Lens In Vivo Free
PDF
Jos J. Rozema; David A. Atchison; Sanjeev Kasthurirangan; James M. Pope; Marie-José Tassignon
Tags: lens (device), lens, crystalline, biometry
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2533-2540. doi:https://doi.org/10.1167/iovs.11-8645
Shape Perception Is Altered by Normal Aging Free
PDF
Anne E. Weymouth; Allison M. McKendrick
Tags: aging, form perception, glass, older adult
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3226-3233. doi:https://doi.org/10.1167/iovs.11-8807

Perspective

Animal Models of Retinal Injury Free
PDF
Richard J. Blanch; Zubair Ahmed; Martin Berry; Robert A. H. Scott; Ann Logan
Tags: animal model, axon, cell death, eye, retinal injuries
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 2913-2920. doi:https://doi.org/10.1167/iovs.11-8564

Letters to the Editor

Are Linear Regression Techniques Appropriate for Analysis When the Dependent (Outcome) Variable Is Not Normally Distributed? Free
PDF
Xiang Li; Wanling Wong; Ecosse L. Lamoureux; Tien Y Wong
Tags: linear regression
Investigative Ophthalmology & Visual Science May 2012, Vol.53, 3082-3083. doi:https://doi.org/10.1167/iovs.12-9967
Copyright © 2025 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.Accept