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Anatomy and Pathology/Oncology

Embryonic Retinal Tumors in SV40 T-Ag Transgenic Mice Contain CD133+ Tumor-Initiating Cells Free
PDF
Lalita Wadhwa; Wesley S. Bond; Laszlo Perlaky; Paul A. Overbeek; Mary Y. Hurwitz; Patricia Chévez-Barrios; Richard L. Hurwitz
Tags: embryo, mice, transgenic, neoplasms, retinal neoplasms, retinoblastoma
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3454-3462. doi:https://doi.org/10.1167/iovs.12-9549
Invasion of Lymphatic Vessels into the Eye after Open Globe Injuries Free
PDF
Julia M. Wessel; Carmen Hofmann-Rummelt; Friedrich E. Kruse; Claus Cursiefen; Ludwig M. Heindl
Tags: eye, lymphatic vessels, open wound of eyeball, wounds and injuries
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3717-3725. doi:https://doi.org/10.1167/iovs.12-9507
Physiologic Properties of Müller Cells from Human Eyes Affected with Uveal Melanoma Free
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Antje Grosche; Thomas Pannicke; Anett Karl; Ianors Iandiev; Mike Francke; Peter Wiedemann; Andreas Reichenbach; Andreas Bringmann
Tags: edema, eye, melanoma, uveal melanoma, hypotonicity
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4170-4176. doi:https://doi.org/10.1167/iovs.12-9746

Biochemistry and Molecular Biology

Divalent Cations in Tears, and Their Influence on Tear Film Stability in Humans and Rabbits Free
PDF
Xiaojia Eric Wei; Maria Markoulli; Thomas J. Millar; Mark D. P. Willcox; Zhenjun Zhao
Tags: divalent cations, oryctolagus cuniculus, tear film finding
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3280-3285. doi:https://doi.org/10.1167/iovs.12-9558
Chemical Chaperone TUDCA Preserves Cone Photoreceptors in a Mouse Model of Leber Congenital Amaurosis Free
PDF
Tao Zhang; Wolfgang Baehr; Yingbin Fu
Tags: leber's amaurosis, mice, molecular chaperones, retinal cone, retina
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3349-3356. doi:https://doi.org/10.1167/iovs.12-9851
A Connective Tissue Growth Factor Signaling Receptor in Corneal Fibroblasts Free
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Timothy D. Blalock; Daniel J. Gibson; Matthew R. Duncan; Sonal S. Tuli; Gary R. Grotendorst; Gregory S. Schultz
Tags: connective tissue growth factor, fibroblasts
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3387-3394. doi:https://doi.org/10.1167/iovs.12-9425
Evaluation and Quantitation of Intact Wax Esters of Human Meibum by Gas-Liquid Chromatography-Ion Trap Mass Spectrometry Free
PDF
Igor A. Butovich; Juan C. Arciniega; Hua Lu; Mike Molai
Tags: cd40 ligand, esters, ions, lipids, thyroid hormone associated protein complex
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3766-3781. doi:https://doi.org/10.1167/iovs.11-9333
Functional Characterization of the Human RPGR Proximal Promoter Free
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Xinhua Shu; Julie R. Simpson; Alan W. Hart; Zhihong Zeng; Sarita Rani Patnaik; Philippe Gautier; Emma Murdoch; Brian Tulloch; Alan F. Wright
Tags: genes, luciferases, mice, transgenic, promoter regions (genetics), binding sites
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3951-3958. doi:https://doi.org/10.1167/iovs.11-8811

Clinical and Epidemiologic Research

Associations of IL-23 with Polypoidal Choroidal Vasculopathy Free
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Shin-ichi Sasaki; Dai Miyazaki; Ken-ichiro Miyake; Yuki Terasaka; Shuzo Kaneda; Yoshifumi Ikeda; Taisaku Funakoshi; Takashi Baba; Atsushi Yamasaki; Yoshitsugu Inoue
Tags: cytokine, interleukin-23, vascular diseases
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3424-3430. doi:https://doi.org/10.1167/iovs.11-7913
Anisometropia in Children from Infancy to 15 Years Free
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Li Deng; Jane E. Gwiazda
Tags: anisometropia, child, refractive errors, infant
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3782-3787. doi:https://doi.org/10.1167/iovs.11-8727
Antithrombotic Medication and Incident Open-Angle Glaucoma Free
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Michael W. Marcus; Rogier P. H. M. Müskens; Wishal D. Ramdas; Roger C. W. Wolfs; Paulus T. V. M. de Jong; Johannes R. Vingerling; Albert Hofman; Bruno H. C. Stricker; Nomdo M. Jansonius
Tags: anticoagulants, fibrinolytic agents, glaucoma, open-angle glaucoma, pharmaceutical preparations
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3801-3805. doi:https://doi.org/10.1167/iovs.12-9604
Long-Term Effect of Overnight Orthokeratology on Axial Length Elongation in Childhood Myopia: A 5-Year Follow-Up Study Free
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Takahiro Hiraoka; Tetsuhiko Kakita; Fumiki Okamoto; Hideto Takahashi; Tetsuro Oshika
Tags: child, follow-up, myopia, orthokeratology, eyeglasses
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3913-3919. doi:https://doi.org/10.1167/iovs.11-8453
Comparison of Refraction and Ocular Biometry in European Caucasian Children Living in Northern Ireland and Sydney, Australia Free
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Amanda N. French; Lisa O'Donoghue; Ian G. Morgan; Kathryn J. Saunders; Paul Mitchell; Kathryn A. Rose
Tags: biometry, child, european continental ancestry group, myopia, northern ireland
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4021-4031. doi:https://doi.org/10.1167/iovs.12-9556
The Importance of Rating Scale Design in the Measurement of Patient-Reported Outcomes Using Questionnaires or Item Banks Free
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Jyoti Khadka; Colm McAlinden; Vijaya K. Gothwal; Ecosse L. Lamoureux; Konrad Pesudovs
Tags: calibration, patient self-report, questionnaires, vision, cataract
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4042-4054. doi:https://doi.org/10.1167/iovs.12-9728
Eye Size in Threshold Retinopathy of Prematurity, Based on a Danish Preterm Infant Series: Early Axial Eye Growth, Pre- and Postnatal Aspects Free
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Hans Callø Fledelius; Christian Fledelius
Tags: danish, eye, infant, premature, retinopathy of prematurity, infant, small for gestational age
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4177-4184. doi:https://doi.org/10.1167/iovs.12-9516

Cornea

Depletion of SLC4A11 Causes Cell Death by Apoptosis in an Immortalized Human Corneal Endothelial Cell Line Free
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Jun Liu; Li-Fong Seet; Li Wei Koh; Anandalakshmi Venkatraman; Divya Venkataraman; Rajiv R. Mohan; Jeppe Praetorius; Joseph A. Bonanno; Tin Aung; Eranga N. Vithana
Tags: apoptosis, cell death, cornea, endothelial cells, polymerase chain reaction
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3270-3279. doi:https://doi.org/10.1167/iovs.11-8724
Corneal Topographic Analysis by 3-Dimensional Anterior Segment Optical Coherence Tomography after Endothelial Keratoplasty Free
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Ritsuko Higashiura; Naoyuki Maeda; Tomoya Nakagawa; Mutsumi Fuchihata; Shizuka Koh; Yuichi Hori; Tomoyuki Inoue; Kohji Nishida
Tags: cornea, keratoplasty, tissue transplants, endothelium, descemet stripping endothelial keratoplasty
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3286-3295. doi:https://doi.org/10.1167/iovs.12-9602
Angiogenesis Potential of Human Limbal Stromal Niche Cells Free
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Gui-Gang Li; Szu-Yu Chen; Hua-Tao Xie; Ying-Ting Zhu; Scheffer C. G. Tseng
Tags: angiogenesis, endothelial cells, epithelium, serial passage, pericytes
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3357-3367. doi:https://doi.org/10.1167/iovs.11-9414
Visualizing Hydrophobic Domains in Silicone Hydrogel Lenses with Sudan IV Free
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Jean T. Jacob; Jacques Levet, Jr; Tamika A. Edwards; Nissanke Dassanayake; Howard Ketelson
Tags: hydrogel, hydrophobicity, lens (device), lens, crystalline, silicones
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3473-3480. doi:https://doi.org/10.1167/iovs.11-9104
Fast Fourier Transform–Based Analysis of Second-Harmonic Generation Image in Keratoconic Cornea Free
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Wen Lo; Wei-Liang Chen; Chiu-Mei Hsueh; Ara A Ghazaryan; Shean-Jen Chen; David Hui-Kang Ma; Chen-Yuan Dong; Hsin-Yuan Tan
Tags: cornea, fourier analysis, harmonics, diagnostic imaging
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3501-3507. doi:https://doi.org/10.1167/iovs.10-6697
Critical Role of TNF-α-Induced Macrophage VEGF and iNOS Production in the Experimental Corneal Neovascularization Free
PDF
Peirong Lu; Longbiao Li; Gaoqin Liu; Tomohisa Baba; Yuko Ishida; Mizuho Nosaka; Toshikazu Kondo; Xueguang Zhang; Naofumi Mukaida
Tags: alkalies, macrophages, nitric oxide synthase, tumor necrosis factors, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3516-3526. doi:https://doi.org/10.1167/iovs.10-5548
Pro-Inflammatory Cytokines and Gelatinases in Climatic Droplet Keratopathy Free
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Juha M. Holopainen; Alexandra Robciuc; Thamara A. Cafaro; Maria F. Suarez; Yrjö T. Konttinen; Hind M. Alkatan; Khalid F. Tabbara; Taina Tervahartiala; Timo Sorsa; Julio A. Urrets-Zavalia; Horacio M. Serra
Tags: cornea, cytokine, gelatinase a, gelatinase b, gelatinases
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3527-3535. doi:https://doi.org/10.1167/iovs.12-9441
PDE4 Inhibition Suppresses IL-17–Associated Immunity in Dry Eye Disease Free
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Zahra Sadrai; William Stevenson; Andre Okanobo; Yihe Chen; Thomas H. Dohlman; Jing Hua; Francisco Amparo; Sunil K. Chauhan; Reza Dana
Tags: cilomilast, interleukin-17, dry eye syndromes, immunity, cornea
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3584-3591. doi:https://doi.org/10.1167/iovs.11-9110
Kinetics and Function of Mesenchymal Stem Cells in Corneal Injury Free
PDF
Yinan Lan; Shilpa Kodati; Hyun Soo Lee; Masahiro Omoto; Yiping Jin; Sunil K. Chauhan
Tags: cornea, corneal injuries, mesenchymal stem cells, wounds and injuries, kinetics
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3638-3644. doi:https://doi.org/10.1167/iovs.11-9311
Corneal Power Is Correlated with Anterior Chamber Diameter Free
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Rafael Iribarren; Fernando Fuentes Bonthoux; Tomas Pfortner; Pablo Chiaradia; William K. Stell
Tags: anterior chamber of eye, cornea, diameter
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3788-3791. doi:https://doi.org/10.1167/iovs.11-8949
Theoretical, Experimental, and Optical Coherence Tomography (OCT) Studies of Graft Apposition and Adhesion in Descemets Stripping Automated Endothelial Keratoplasty (DSAEK) Free
PDF
Maninder S. Bhogal; Romesh I. Angunawela; Emiliano Bilotti; Ian Eames; Bruce D. Allan
Tags: adhesions, descemet stripping endothelial keratoplasty, tissue transplants, keratoplasty, endothelium
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3839-3846. doi:https://doi.org/10.1167/iovs.12-9593
Fibrinogen, Riboflavin, and UVA to Immobilize a Corneal Flap—Conditions for Tissue Adhesion Free
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Stacy L. Littlechild; Gage Brummer; Yuntao Zhang; Gary W. Conrad
Tags: adhesions, cornea, ultraviolet a radiation, surgical flaps, riboflavin
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4011-4020. doi:https://doi.org/10.1167/iovs.12-9515
Downregulation of β-Actin Gene and Human Antigen R in Human Keratoconus Free
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Roy Joseph; Om P. Srivastava; Roswell R. Pfister
Tags: actins, antigens, cornea, down-regulation, genes
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4032-4041. doi:https://doi.org/10.1167/iovs.11-9062
Silk Fibroin as a Biomaterial Substrate for Corneal Epithelial Cell Sheet Generation Free
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Jingbo Liu; Brian D. Lawrence; Aihong Liu; Ivan R. Schwab; Lauro A. Oliveira; Mark I. Rosenblatt
Tags: biomaterials, corneal epithelial cells, fibroins, cell proliferation, epithelium
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4130-4138. doi:https://doi.org/10.1167/iovs.12-9876
Inhibition by Medroxyprogesterone Acetate of Interleukin-1β–Induced Collagen Degradation by Corneal Fibroblasts Free
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Hongyan Zhou; Kazuhiro Kimura; Tomoko Orita; Teruo Nishida; Koh-Hei Sonoda
Tags: catabolism, collagen, cornea, fibroblasts, interleukins
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4213-4219. doi:https://doi.org/10.1167/iovs.11-8822
Thermal Load from a CO2 Laser Radiant Energy Source Induces Changes in Corneal Surface Asphericity, Roughness, and Transverse Contraction Free
PDF
Sean J. McCafferty; Jim T. Schwiegerling; Eniko T. Enikov
Tags: carbon dioxide lasers, cornea, lasers, temperature, ablation
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4279-4288. doi:https://doi.org/10.1167/iovs.12-9579

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Abnormal Radial Deformation Hyperacuity in Children with Strabismic Amblyopia Free
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Vidhya Subramanian; Sarah E. Morale; Yi-Zhong Wang; Eileen E. Birch
Tags: child, strabismic amblyopia, amblyopia, visual acuity
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3303-3308. doi:https://doi.org/10.1167/iovs.11-8774
Are There Any Left-Right Asymmetries in Saccade Parameters? Examination of Latency, Gain, and Peak Velocity Free
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Dorine Vergilino-Perez; Alexandra Fayel; Christelle Lemoine; Patrice Senot; Judith Vergne; Karine Doré-Mazars
Tags: saccades, velocity, eye, ocular dominance
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3340-3348. doi:https://doi.org/10.1167/iovs.11-9273
Responses of Cells in the Midbrain Near-Response Area in Monkeys with Strabismus Free
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Vallabh E. Das
Tags: accommodative reflex, cercopithecidae, eye, neurons, strabismus
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3858-3864. doi:https://doi.org/10.1167/iovs.11-9145
Quantification of Retinal Neural Loss in Patients with Neuromyelitis Optica and Multiple Sclerosis with or without Optic Neuritis Using Fourier-Domain Optical Coherence Tomography Free
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Mário L. R. Monteiro; Danilo B. Fernandes; Samira L. Apóstolos-Pereira; Dagoberto Callegaro
Tags: eye, multiple sclerosis, neuromyelitis optica, optic neuritis, optical coherence tomography
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3959-3966. doi:https://doi.org/10.1167/iovs.11-9324
Automated Quantification of Volumetric Optic Disc Swelling in Papilledema Using Spectral-Domain Optical Coherence Tomography Free
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Jui-Kai Wang; Randy H. Kardon; Mark J. Kupersmith; Mona K. Garvin
Tags: optical coherence tomography, papilledema, volume, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4069-4075. doi:https://doi.org/10.1167/iovs.12-9438

Genetics

Chromosome 3 Status in Uveal Melanoma: A Comparison of Fluorescence In Situ Hybridization and Single-Nucleotide Polymorphism Array Free
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Arun D. Singh; Mary E. Aronow; Yang Sun; Gurkan Bebek; Yogen Saunthararajah; Lynn R. Schoenfield; Charles V. Biscotti; Raymond R. Tubbs; Pierre L. Triozzi; Charis Eng
Tags: chromosomes, human, pair 3, fluorescent in situ hybridization, monosomy, neoplasms, single nucleotide polymorphism
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3331-3339. doi:https://doi.org/10.1167/iovs.11-9027
Mutations in RD3 Are Associated with an Extremely Rare and Severe Form of Early Onset Retinal Dystrophy Free
PDF
Markus N. Preising; Nora Hausotter-Will; Manuel C. Solbach; Christoph Friedburg; Franz Rüschendorf; Birgit Lorenz
Tags: mutation, perimetry, retinal dystrophies, family, electroretinography
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3463-3472. doi:https://doi.org/10.1167/iovs.12-9519
Association of TP53 Polymorphisms with Primary Open-Angle Glaucoma: A Meta-Analysis Free
PDF
Yatu Guo; Hongtuan Zhang; Xia Chen; Xiong Yang; Wenbo Cheng; Kanxing Zhao
Tags: glaucoma, meta-analysis, open-angle glaucoma, polymorphism, protein p53
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3756-3763. doi:https://doi.org/10.1167/iovs.12-9818
Early Onset Retinal Dystrophy Due to Mutations in LRAT: Molecular Analysis and Detailed Phenotypic Study Free
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Arundhati Dev Borman; Louise A. Ocaka; Donna S. Mackay; Caterina Ripamonti; Robert H. Henderson; Phillip Moradi; Georgina Hall; Graeme C. Black; Anthony G. Robson; Graham E. Holder; Andrew R. Webster; Fred Fitzke; Andrew Stockman; Anthony T. Moore
Tags: mutation, phenotype, retinal dystrophies, perimetry
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3927-3938. doi:https://doi.org/10.1167/iovs.12-9548
Gene Repair of an Usher Syndrome Causing Mutation by Zinc-Finger Nuclease Mediated Homologous Recombination Free
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Nora Overlack; Tobias Goldmann; Uwe Wolfrum; Kerstin Nagel-Wolfrum
Tags: genes, mutation, nuclease, recombination, genetic, usher syndrome
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4140-4146. doi:https://doi.org/10.1167/iovs.12-9812
Variation in the Lysyl Oxidase (LOX) Gene Is Associated with Keratoconus in Family-Based and Case-Control Studies Free
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Yelena Bykhovskaya; Xiaohui Li; Irina Epifantseva; Talin Haritunians; David Siscovick; Anthony Aldave; Loretta Szczotka-Flynn; Sudha K. Iyengar; Kent D. Taylor; Jerome I. Rotter; Yaron S Rabinowitz
Tags: family, genes, genome-wide association study, keratoconus, protein-lysine 6-oxidase
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4152-4157. doi:https://doi.org/10.1167/iovs.11-9268
Association of Genetic Polymorphisms and Age-Related Macular Degeneration in Chinese Population Free
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Jun Tian; Wenzhen Yu; Xueying Qin; Kai Fang; Qing Chen; Jing Hou; Juan Li; Dafang Chen; Yonghua Hu; Xiaoxin Li
Tags: age-related macular degeneration, chinese (other dialects), chinese people, polymorphism, cholesterol ester transfer proteins
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4262-4269. doi:https://doi.org/10.1167/iovs.11-8542

Glaucoma

Two-Photon Immunofluorescence Characterization of the Trabecular Meshwork In Situ Free
PDF
Jose M. Gonzalez, Jr; Martin Heur; James C. H. Tan
Tags: antibodies, body tissue, donors, fluorescent antibody technique, glaucoma
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3395-3404. doi:https://doi.org/10.1167/iovs.11-8570
Factors Predicting the Rate of Functional Progression in Early and Suspected Glaucoma Free
PDF
Stuart K. Gardiner; Chris A. Johnson; Shaban Demirel
Tags: glaucoma, intraocular pressure, visual fields
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3598-3604. doi:https://doi.org/10.1167/iovs.11-9065
Localized Glaucomatous Change Detection within the Proper Orthogonal Decomposition Framework Free
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Madhusudhanan Balasubramanian; David J. Kriegman; Christopher Bowd; Michael Holst; Robert N. Weinreb; Pamela A. Sample; Linda M. Zangwill
Tags: follow-up, glaucoma, eye, type i errors, bonferroni method
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3615-3628. doi:https://doi.org/10.1167/iovs.11-8847
Do Patients with Glaucoma Have Difficulty Recognizing Faces? Free
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Fiona C. Glen; David P. Crabb; Nicholas D. Smith; Robyn Burton; David F. Garway-Heath
Tags: facial recognition, glaucoma, vision, eye, face
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3629-3637. doi:https://doi.org/10.1167/iovs.11-8538
Variance Reduction in a Dataset of Normal Macular Ganglion Cell Plus Inner Plexiform Layer Thickness Maps with Application to Glaucoma Diagnosis Free
PDF
Robert W. Knighton; Giovanni Gregori; Donald L. Budenz
Tags: ganglia, glaucoma, heterogeneity of variance, maps, eye
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3653-3661. doi:https://doi.org/10.1167/iovs.12-9719
Microbead-Induced Ocular Hypertensive Mouse Model for Screening and Testing of Aqueous Production Suppressants for Glaucoma Free
PDF
Qiang Yang; Kin-Sang Cho; Huihui Chen; Dekuang Yu; Wan-Heng Wang; Gang Luo; Iok-Hou Pang; Wenyi Guo; Dong Feng Chen
Tags: glaucoma, intraocular pressure, mice, microspheres, ocular hypertension
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3733-3741. doi:https://doi.org/10.1167/iovs.12-9814
Proteomics Analyses of Activated Human Optic Nerve Head Lamina Cribrosa Cells following Biomechanical Strain Free
PDF
Ronan Rogers; Moyez Dharsee; Suzanne Ackloo; John G. Flanagan
Tags: cribriform plate, proteins, proteomics, optic disk, regulation
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3806-3816. doi:https://doi.org/10.1167/iovs.11-8480
Detection of Glaucoma Progression by Assessment of Segmented Macular Thickness Data Obtained Using Spectral Domain Optical Coherence Tomography Free
PDF
Jung Hwa Na; Kyung Rim Sung; Seunghee Baek; Yoon Jeon Kim; Mary K. Durbin; Hye Jin Lee; Hwang Ki Kim; Yong Ho Sohn
Tags: glaucoma, optical coherence tomography, retinal nerve fiber layer, optic disk, eye
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3817-3826. doi:https://doi.org/10.1167/iovs.11-9369
Retinal Ganglion Cell Morphology after Optic Nerve Crush and Experimental Glaucoma Free
PDF
Giedrius Kalesnykas; Ericka N. Oglesby; Donald J. Zack; Frances E. Cone; Matthew R. Steinhart; Jing Tian; Mary E. Pease; Harry A. Quigley
Tags: glaucoma, language morphology, morphology, optic nerve, retinal ganglion cells
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3847-3857. doi:https://doi.org/10.1167/iovs.12-9712
Predictive Value of Retrobulbar Blood Flow Velocities in Glaucoma Suspects Free
PDF
Pilar Calvo; Antonio Ferreras; Vicente Polo; Noemi Güerri; Pilar Seral; Isabel Fuertes-Lazaro; Luis E. Pablo
Tags: blood flow velocity, glaucoma, magnetic resonance angiography, mineralocorticoid receptor antagonists, predictive value
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3875-3884. doi:https://doi.org/10.1167/iovs.11-8817
Structural and Functional Abnormalities of Retinal Ganglion Cells Measured In Vivo at the Onset of Optic Nerve Head Surface Change in Experimental Glaucoma Free
PDF
Brad Fortune; Claude F. Burgoyne; Grant A. Cull; Juan Reynaud; Lin Wang
Tags: electroretinography, eye, glaucoma, optic disk, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3939-3950. doi:https://doi.org/10.1167/iovs.12-9979
Biometric Evaluation of Anterior Chamber Changes after Physiologic Pupil Dilation Using Pentacam and Anterior Segment Optical Coherence Tomography Free
PDF
Florent Aptel; Christophe Chiquet; Sylvain Beccat; Philippe Denis
Tags: anterior chamber of eye, biometry, eye, immune reconstitution inflammatory syndrome, iris
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4005-4010. doi:https://doi.org/10.1167/iovs.11-9387
In Vivo Imaging of Lamina Cribrosa Pores by Adaptive Optics Scanning Laser Ophthalmoscopy Free
PDF
Tadamichi Akagi; Masanori Hangai; Kohei Takayama; Atsushi Nonaka; Sotaro Ooto; Nagahisa Yoshimura
Tags: cribriform plate, diagnostic imaging, glaucoma, optics, scanning laser ophthalmoscopy
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4111-4119. doi:https://doi.org/10.1167/iovs.11-7536
Differences between Proximal versus Distal Intraorbital Optic Nerve Diffusion Tensor Magnetic Resonance Imaging Properties in Glaucoma Patients Free
PDF
Francesca Bolacchi; Francesco Giuseppe Garaci; Alessio Martucci; Alessandro Meschini; Maria Fornari; Simone Marziali; Raffaele Mancino; Ettore Squillaci; Roberto Floris; Luciano Cerulli; Giovanni Simonetti; Carlo Nucci
Tags: diffusion, glaucoma, magnetic resonance imaging, optic nerve, eye
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4191-4196. doi:https://doi.org/10.1167/iovs.11-9345
An Astrocyte-Specific Proteomic Approach to
Inflammatory Responses in Experimental Rat Glaucoma Free
PDF
Gülgün Tezel; Xiangjun Yang; Cheng Luo; Jian Cai; David W. Powell
Tags: astrocytes, glaucoma, inflammatory response, ocular hypertension, proteins
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4220-4233. doi:https://doi.org/10.1167/iovs.11-9101
New Proteins as Vascular Biomarkers in Primary Open Angle Glaucomatous Aqueous Humor Free
PDF
Sergio Claudio Saccà; Marco Centofanti; Alberto Izzotti
Tags: aqueous humor, glaucoma, proteins, biological markers, open-angle glaucoma
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4242-4253. doi:https://doi.org/10.1167/iovs.11-8902
A Few Good Responses: Which Mechanical Effects of IOP on the ONH to Study? Free
PDF
Ian A. Sigal; Jonathan L. Grimm
Tags: biomechanics, intraocular pressure, optic disk, heterogeneity of variance, sclera
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4270-4278. doi:https://doi.org/10.1167/iovs.11-8739

Immunology and Microbiology

PTX3 Controls Activation of Matrix Metalloproteinase 1 and Apoptosis in Conjunctivochalasis Fibroblasts Free
PDF
Ping Guo; Su-Zhen Zhang; Hua He; Ying-Ting Zhu; Scheffer C. G. Tseng
Tags: apoptosis, conjunctivochalasis, fibroblasts, interstitial collagenase, ptx3 protein
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3414-3423. doi:https://doi.org/10.1167/iovs.11-9103
Antidiabetic Drug Metformin Suppresses Endotoxin-Induced Uveitis in Rats Free
PDF
Nilesh M. Kalariya; Mohammad Shoeb; Naseem H. Ansari; Satish K. Srivastava; Kota V. Ramana
Tags: endotoxins, metformin, uveitis, rats, antidiabetics
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3431-3440. doi:https://doi.org/10.1167/iovs.12-9432
Anti-Inflammatory Effect of the Proteasome Inhibitor Bortezomib on Endotoxin-Induced Uveitis in Rats Free
PDF
Fang-Ting Chen; Yi-Chun Liu; Chung-May Yang; Chang-Hao Yang
Tags: bortezomib, rats, inflammation mediators, proteasome inhibitors, anti-inflammatory agents
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3682-3694. doi:https://doi.org/10.1167/iovs.12-9505
Simultaneous Analysis of Multiple Cytokines in the Vitreous of Patients with Sarcoid Uveitis Free
PDF
Kenji Nagata; Kazuichi Maruyama; Kazuko Uno; Katsuhiko Shinomiya; Kazuhito Yoneda; Junji Hamuro; Sunao Sugita; Takeru Yoshimura; Koh-Hei Sonoda; Manabu Mochizuki; Shigeru Kinoshita
Tags: cytokine, sarcoidosis, uveitis, vitreous body, ocular sarcoidosis
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3827-3833. doi:https://doi.org/10.1167/iovs.11-9244
Bacterial Biofilm Diversity in Contact Lens-Related Disease: Emerging Role of Achromobacter, Stenotrophomonas, and Delftia Free
PDF
Lee Wiley; Dacie R. Bridge; Lee A. Wiley; J. Vernon Odom; Thomas Elliott; Joan C. Olson
Tags: achromobacter, biofilms, genes, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3896-3905. doi:https://doi.org/10.1167/iovs.11-8762
Aminoimidazole Carboxamide Ribonucleotide Ameliorates Experimental Autoimmune Uveitis Free
PDF
Jun Suzuki; Takeru Yoshimura; Marina Simeonova; Kimio Takeuchi; Yusuke Murakami; Yuki Morizane; Joan W. Miller; Lucia Sobrin; Demetrios G. Vavvas
Tags: aica ribonucleotide, uveitis, autoimmune diseases
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4158-4169. doi:https://doi.org/10.1167/iovs.11-9323
Immunopathologic Processes in Sympathetic Ophthalmia as Signified by MicroRNA Profiling Free
PDF
Yutaka Kaneko; Guey Shuang Wu; Sindhu Saraswathy; Daniel V. Vasconcelos-Santos; Narsing A. Rao
Tags: micrornas, ophthalmia, sympathetic, tumor necrosis factors, nitric oxide synthase, polymerase chain reaction
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4197-4204. doi:https://doi.org/10.1167/iovs.12-9465

Lens

Activation of the Hedgehog Signaling Pathway in the Developing Lens Stimulates Ectopic FoxE3 Expression and Disruption in Fiber Cell Differentiation Free
PDF
Christine L. Kerr; Jian Huang; Trevor Williams; Judith A. West-Mays
Tags: lens (device), lens, crystalline, cell differentiation, mice
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3316-3330. doi:https://doi.org/10.1167/iovs.12-9595
Racemization of Two Proteins over Our Lifespan: Deamidation of Asparagine 76 in γS Crystallin Is Greater in Cataract than in Normal Lenses across the Age Range Free
PDF
Michelle Yu Sung Hooi; Mark J. Raftery; Roger John Willis Truscott
Tags: cataract, crystallins, lens (device), lens, crystalline, proteins
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3554-3561. doi:https://doi.org/10.1167/iovs.11-9085
Smoking and Risk of Age-Related Cataract: A Meta-Analysis Free
PDF
Juan Ye; Jinjing He; Changjun Wang; Han Wu; Xin Shi; Huina Zhang; Jiajun Xie; Sang Yeul Lee
Tags: cataract, senile, meta-analysis, smoking
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3885-3895. doi:https://doi.org/10.1167/iovs.12-9820
Discrepant Expression of MicroRNAs in Transparent and Cataractous Human Lenses Free
PDF
Changrui Wu; Haotian Lin; Qilin Wang; Wan Chen; Haihua Luo; Weirong Chen; Hui Zhang
Tags: lens, crystalline, micrornas
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3906-3912. doi:https://doi.org/10.1167/iovs.11-9178
Spectral Transmission of the Human Crystalline Lens in Adult and Elderly Persons: Color and Total Transmission of Visible Light Free
PDF
Jose M. Artigas; Adelina Felipe; Amparo Navea; Adriana Fandiño; Cristina Artigas
Tags: adult, color, lens, crystalline, older adult, visible light
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4076-4084. doi:https://doi.org/10.1167/iovs.12-9471
MMP2 Activity is Critical for TGFβ2-Induced Matrix Contraction—Implications for Fibrosis Free
PDF
Julie A. Eldred; Lisa M. Hodgkinson; Lucy J. Dawes; John R. Reddan; Dylan R. Edwards; I. Michael Wormstone
Tags: gelatinase a
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4085-4098. doi:https://doi.org/10.1167/iovs.12-9457

Low Vision

Patients with Central Visual Field Loss Adopt a Cautious Gait Strategy during Tasks That Present a High Risk of Falling Free
PDF
Matthew A. Timmis; Shahina Pardhan
Tags: blindness, gait, gait, elderly, calcaneofibular ligament, foot
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4120-4129. doi:https://doi.org/10.1167/iovs.12-9897
The Impact of Visual and Nonvisual Factors on Quality of Life and Adaptation in Adults with Visual Impairment Free
PDF
Ana Hernandez Trillo; Christine M. Dickinson
Tags: adult, quality of life, visual impairment, outcome measures, questionnaires
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4234-4241. doi:https://doi.org/10.1167/iovs.12-9580

Multidisciplinary Ophthalmic Imaging

Magnetic Resonance Compatibility of Intraocular Lenses Measured at 7 Tesla Free
PDF
Gwyneth A. van Rijn; Jurgen E. M. Mourik; Wouter M. Teeuwisse; Gregorius P. M. Luyten; Andrew G. Webb
Tags: artifacts, intraocular lens implant device, magnetic resonance imaging, vibration, heating
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3449-3453. doi:https://doi.org/10.1167/iovs.12-9610
Variability in Bleach Kinetics and Amount of Photopigment between Individual Foveal Cones Free
PDF
Phillip Bedggood; Andrew Metha
Tags: bleach, kinetics, retinal cone, optics, pigment
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3673-3681. doi:https://doi.org/10.1167/iovs.11-8796
Comparison of Retinal Nerve Fiber Layer Thickness Measurement Bias and Imprecision across Three Spectral-Domain Optical Coherence Tomography Devices Free
PDF
Nancy M. Buchser; Gadi Wollstein; Hiroshi Ishikawa; Richard A. Bilonick; Yun Ling; Lindsey S. Folio; Larry Kagemann; Robert J. Noecker; Eiyass Albeiruti; Joel S. Schuman
Tags: glaucoma, optical coherence tomography, retinal nerve fiber layer, eye
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3742-3747. doi:https://doi.org/10.1167/iovs.11-8432

Physiology and Pharmacology

GABA-Induced Relaxation of Porcine Retinal Arterioles in Vitro Depends on Inhibition from the Perivascular Retina and Is Mediated by GABAC Receptors Free
PDF
Toke Bek; Kim Holmgaard
Tags: arteriole, gamma-aminobutyric acid, retina, suidae
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3309-3315. doi:https://doi.org/10.1167/iovs.12-9838
Blocking Endothelin-B Receptors Rescues Retinal Ganglion Cells from Optic Nerve Injury through Suppression of Neuroinflammation Free
PDF
Masahiro Tonari; Takuji Kurimoto; Taeko Horie; Tetsuya Sugiyama; Tsunehiko Ikeda; Hidehiro Oku
Tags: cd68 antigen, human, endothelins, glial fibrillary acidic protein, optic nerve, optic nerve injuries
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3490-3500. doi:https://doi.org/10.1167/iovs.11-9415
Expression and Activity of p-Glycoprotein Elevated by Dexamethasone in Cultured Retinal Pigment Epithelium Involve Glucocorticoid Receptor and Pregnane X Receptor Free
PDF
Yuehong Zhang; Min Lu; Xuerong Sun; Chunmei Li; Xielan Kuang; Xiangcai Ruan
Tags: dexamethasone, p-glycoprotein, glucocorticoid receptors, pregnanes
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3508-3515. doi:https://doi.org/10.1167/iovs.11-9337
Involvement of Glial Cells in the Autoregulation of Optic Nerve Head Blood Flow in Rabbits Free
PDF
Maho Shibata; Tetsuya Sugiyama; Takuji Kurimoto; Hidehiro Oku; Takashi Okuno; Takatoshi Kobayashi; Tsunehiko Ikeda
Tags: homeostasis, intraocular pressure, neuroglia, optic disk, oryctolagus cuniculus
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3726-3732. doi:https://doi.org/10.1167/iovs.11-9316
Retinal Vessel Oxygen Saturation under Flicker Light Stimulation in Patients with Nonproliferative Diabetic Retinopathy Free
PDF
Martin Hammer; Tabitha Heller; Susanne Jentsch; Jens Dawczynski; Dietrich Schweitzer; Sven Peters; Kai-Uwe Schmidtke; Ulrich-Alfons Müller
Tags: diabetic retinopathy, nonproliferative diabetic retinopathy, oxygen saturation measurement, photopsia, retinal vessels
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4063-4068. doi:https://doi.org/10.1167/iovs.12-9659
Neuroprotective Effects of Angiotensin II Type 1 Receptor (AT1-R) Blocker via Modulating AT1-R Signaling and Decreased Extracellular Glutamate Levels Free
PDF
Tomoyoshi Fujita; Kazuyuki Hirooka; Takehiro Nakamura; Toshifumi Itano; Akira Nishiyama; Yukiko Nagai; Fumio Shiraga
Tags: candesartan cilexetil, glutamate, glutamates, ischemia, retina
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4099-4110. doi:https://doi.org/10.1167/iovs.11-9167
Preservation of Retina Ganglion Cell Function by Morphine in a Chronic Ocular-Hypertensive Rat Model Free
PDF
Shahid Husain; Yasir Abdul; Craig E. Crosson
Tags: glaucoma, morphine, ocular hypertension, retina, neuroprotection
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4289-4298. doi:https://doi.org/10.1167/iovs.12-9467
Evaluation of Sirtuin Role in Neuroprotection of Retinal Ganglion Cells in Hypoxia Free
PDF
Sankarathi Balaiya; Lee R. Ferguson; Kakarla V. Chalam
Tags: hypoxia, retinal ganglion cells, sirtuins, neuroprotection, cell survival
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4315-4322. doi:https://doi.org/10.1167/iovs.11-9259

Retina

Time-Resolved Autofluorescence Imaging of Human Donor Retina Tissue from Donors with Significant Extramacular Drusen Free
PDF
Dietrich Schweitzer; Elizabeth R. Gaillard; James Dillon; Robert F. Mullins; Stephen Russell; Birgit Hoffmann; Sven Peters; Martin Hammer; Christoph Biskup
Tags: drusen, fluorescence, diagnostic imaging, autofluorescence, donors
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3376-3386. doi:https://doi.org/10.1167/iovs.11-8970
Cone Photoreceptor Packing Density and the Outer Nuclear Layer Thickness in Healthy Subjects Free
PDF
Toco Y. P. Chui; Hongxin Song; Christopher A. Clark; Joel A. Papay; Stephen A. Burns; Ann E. Elsner
Tags: retinal cone, meridians
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3545-3553. doi:https://doi.org/10.1167/iovs.11-8694
Assessment of Macular Function for Idiopathic Epiretinal Membranes Classified by Spectral-Domain Optical Coherence Tomography Free
PDF
Jong-uk Hwang; Joonhong Sohn; Byung Gil Moon; Soo Geun Joe; Joo Yong Lee; June-Gone Kim; Young Hee Yoon
Tags: electroretinography, epiretinal membrane, macular function, optical coherence tomography, eye
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3562-3569. doi:https://doi.org/10.1167/iovs.12-9762
Carcinine Has 4-Hydroxynonenal Scavenging Property and Neuroprotective Effect in Mouse Retina Free
PDF
Lea D. Marchette; Huaiwen Wang; Feng Li; Mark A. Babizhayev; Anne Kasus-Jacobi
Tags: mice, neuroprotection, neuroprotective effect, proteins, retina
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3572-3583. doi:https://doi.org/10.1167/iovs.11-9042
Time Course of Changes in Metamorphopsia, Visual Acuity, and OCT Parameters after Successful Epiretinal Membrane Surgery Free
PDF
Takamasa Kinoshita; Hiroko Imaizumi; Utako Okushiba; Hirotomo Miyamoto; Tetsuo Ogino; Yoshinori Mitamura
Tags: epiretinal membrane, metamorphopsias, surgical procedures, operative, visual acuity, time factors
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3592-3597. doi:https://doi.org/10.1167/iovs.12-9493
Temperature-Controlled Retinal Photocoagulation – A Step Toward Automated Laser Treatment Free
PDF
Stefan Koinzer; Kerstin Schlott; Lars Ptaszynski; Marco Bever; Susanne Kleemann; Mark Saeger; Alexander Baade; Amke Caliebe; Yoko Miura; Reginald Birngruber; Ralf Brinkmann; Johann Roider
Tags: body temperature, laser therapy, lasers, light coagulation, temperature
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3605-3614. doi:https://doi.org/10.1167/iovs.11-8588
Choroidal Thickness, Vascular Hyperpermeability, and Complement Factor H in Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy Free
PDF
Pichai Jirarattanasopa; Sotaro Ooto; Isao Nakata; Akitaka Tsujikawa; Kenji Yamashiro; Akio Oishi; Nagahisa Yoshimura
Tags: age-related macular degeneration, complement factor h, eye, vascular diseases, ranibizumab
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3663-3672. doi:https://doi.org/10.1167/iovs.12-9619
Positioning of Electronic Subretinal Implants in Blind Retinitis Pigmentosa Patients Through Multimodal Assessment of Retinal Structures Free
PDF
Akos Kusnyerik; Udo Greppmaier; Robert Wilke; Florian Gekeler; Barbara Wilhelm; Helmut G. Sachs; Karl Ulrich Bartz-Schmidt; Uwe Klose; Katarina Stingl; Miklos D. Resch; Anusch Hekmat; Anna Bruckmann; Kristof Karacs; Janos Nemeth; Ildiko Suveges; Eberhart Zrenner
Tags: implantation procedure, implants, retinitis pigmentosa
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3748-3755. doi:https://doi.org/10.1167/iovs.11-9409
Morphologic Analysis in Pathologic Myopia Using High-Penetration Optical Coherence Tomography Free
PDF
Ichiro Maruko; Tomohiro Iida; Yukinori Sugano; Hiroshi Oyamada; Masahiro Akiba; Tetsuju Sekiryu
Tags: eye, myopic macular degeneration, optical coherence tomography, sclera, choroid
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3834-3838. doi:https://doi.org/10.1167/iovs.12-9811
The Dark Atrophy with Indocyanine Green Angiography in Stargardt Disease Free
PDF
Andrea Giani; Marco Pellegrini; Elisa Carini; Antonio Peroglio Deiro; Ferdinando Bottoni; Giovanni Staurenghi
Tags: atrophy, indocyanine green angiography, stargardt's disease, atrophic condition of skin
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3999-4004. doi:https://doi.org/10.1167/iovs.11-9258
En Face Enhanced Depth Imaging Optical Coherence Tomography of Fibrovascular Pigment Epithelium Detachment Free
PDF
Florence Coscas; Gabriel Coscas; Giuseppe Querques; Nathalie Massamba; Lea Querques; Francesco Bandello; Eric H. Souied
Tags: choroidal neovascularization, diagnostic imaging, face, optical coherence tomography, pigment
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4147-4151. doi:https://doi.org/10.1167/iovs.12-9878
Focal Macular Electroretinograms after Intravitreal Injections of Bevacizumab for Age-Related Macular Degeneration Free
PDF
Eiji Iwata; Shinji Ueno; Kohei Ishikawa; Yasuki Ito; Ruka Uetani; Chang-Hua Piao; Mineo Kondo; Hiroko Terasaki
Tags: age-related macular degeneration, bevacizumab, electroretinography, intravitreal injections, injections
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4185-4190. doi:https://doi.org/10.1167/iovs.11-9335
Pharmacokinetic Analysis of Melphalan after Superselective Ophthalmic Artery Infusion in Preclinical Models and Retinoblastoma Patients Free
PDF
Paula Schaiquevich; Emiliano Buitrago; Paula Taich; Ana Torbidoni; Alejandro Ceciliano; Adriana Fandino; Marcelo Asprea; Flavio Requejo; David H. Abramson; Guillermo F. Bramuglia; Guillermo L. Chantada
Tags: melphalan, retinoblastoma, infusion procedures, pharmacokinetics, ophthalmic artery
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4205-4212. doi:https://doi.org/10.1167/iovs.12-9501
Transcorneal Electrical Stimulation Promotes Survival of Photoreceptors and Improves Retinal Function in Rhodopsin P347L Transgenic Rabbits Free
PDF
Takeshi Morimoto; Hiroyuki Kanda; Mineo Kondo; Hiroko Terasaki; Kohji Nishida; Takashi Fujikado
Tags: animals, transgenic, electric stimulation, electroretinography, oryctolagus cuniculus, photoreceptors
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4254-4261. doi:https://doi.org/10.1167/iovs.11-9067
Blood Flow MRI of the Human Retina/Choroid during Rest and Isometric Exercise Free
PDF
Yi Zhang; Oscar San Emeterio Nateras; Qi Peng; Carlos A. Rosende; Timothy Q. Duong
Tags: choroid, exercise, isometric, magnetic resonance imaging, retina, vascular flow
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4299-4305. doi:https://doi.org/10.1167/iovs.11-9384
Quantitative Analysis of Retinal Vessel Attenuation in Eyes with Retinitis Pigmentosa Free
PDF
Yaling Ma; Ryo Kawasaki; Lucy P. Dobson; Jonathan B. Ruddle; Lisa S. Kearns; Tien Y. Wong; David A. Mackey
Tags: attenuation, eye, retinal vascular caliber, retinal vessels, retinitis pigmentosa
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4306-4314. doi:https://doi.org/10.1167/iovs.11-8596
Intravitreal Anti-VEGF Therapy Blocks Inflammatory Cell Infiltration and Re-Entry into the Circulation in Retinal Angiogenesis Free
PDF
Shintaro Nakao; Mitsuru Arima; Keijiro Ishikawa; Riichiro Kohno; Shuhei Kawahara; Masanori Miyazaki; Shigeo Yoshida; Hiroshi Enaida; Ali Hafezi-Moghadam; Toshihiro Kono; Tatsuro Ishibashi
Tags: angiogenesis, inflammation, intravitreal injections, leukocytes, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4323-4328. doi:https://doi.org/10.1167/iovs.11-9119

Retinal Cell Biology

ERK1/2 Signaling Pathway in the Release of VEGF from Müller Cells in Diabetes Free
PDF
Xiaofeng Ye; Hui Ren; Meng Zhang; Zhongcui Sun; Alice C. Jiang; Gezhi Xu
Tags: diabetes mellitus, glucose, signal pathway, signal transduction pathways, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3481-3489. doi:https://doi.org/10.1167/iovs.11-9076
Toward an Understanding of Bisretinoid Autofluorescence Bleaching and Recovery Free
PDF
Kazunori Yamamoto; Jilin Zhou; Jennifer J. Hunter; David R. Williams; Janet R. Sparrow
Tags: autofluorescence, fluorescence, recovery of function, energy absorbance, comprehension
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3536-3544. doi:https://doi.org/10.1167/iovs.12-9535
Fas Ligand-Fas Signaling Participates in Light-Induced Apoptotic Death in Photoreceptor Cells Free
PDF
Qing Chang; Marcus E. Peter; Michael A. Grassi
Tags: apoptosis, ligands, photoreceptors, signal transduction, tumor necrosis factor ligand superfamily member 6
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3703-3716. doi:https://doi.org/10.1167/iovs.11-8928
ER Stress Is Involved in T17M Rhodopsin-Induced Retinal Degeneration Free
PDF
Mansi M. Kunte; Shreyasi Choudhury; Jessica F. Manheim; Vishal M. Shinde; Masayuki Miura; Vince A. Chiodo; William W. Hauswirth; Oleg S. Gorbatyuk; Marina S. Gorbatyuk
Tags: gene expression, retina, retinal degeneration, rhodopsin, stress
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3792-3800. doi:https://doi.org/10.1167/iovs.11-9235
Quantitative Retinal Protein Analysis after Optic Nerve Transection Reveals a Neuroprotective Role for Hepatoma-Derived Growth Factor on Injured Retinal Ganglion Cells Free
PDF
Adam Hollander; Philippe M. D'Onofrio; Mark M. Magharious; Meghan D. Lysko; Paulo D. Koeberle
Tags: carcinoma, hepatocellular, growth factor, optic nerve, proteins, axotomy
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3973-3989. doi:https://doi.org/10.1167/iovs.11-8350
Redox Proteomic Identification of Visual Arrestin Dimerization in Photoreceptor Degeneration after Photic Injury Free
PDF
Christopher J. Lieven; Jonathan D. Ribich; Megan E. Crowe; Leonard A. Levin
Tags: arrestin, dimerization, photoreceptors, tissue degeneration, wounds and injuries
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3990-3998. doi:https://doi.org/10.1167/iovs.11-9321
Soluble Vascular Adhesion Protein-1 Accumulates in Proliferative Diabetic Retinopathy Free
PDF
Miyuki Murata; Kousuke Noda; Junichi Fukuhara; Atsuhiro Kanda; Satoru Kase; Wataru Saito; Yoko Ozawa; Satsuki Mochizuki; Shioko Kimura; Yukihiko Mashima; Yasunori Okada; Susumu Ishida
Tags: adhesions, blood capillaries, endothelial cells, glucose, proliferative diabetic retinopathy
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4055-4062. doi:https://doi.org/10.1167/iovs.12-9857

Translational

Larger Therapeutic Window for Steroid versus VEGF-A Inhibitor in Inflammatory Angiogenesis: Surprisingly Similar Impact on Leukocyte Infiltration Free
PDF
Shintaro Nakao; Souska Zandi; Nuria Lara-Castillo; Mahdi Taher; Tatsuro Ishibashi; Ali Hafezi-Moghadam
Tags: angiogenesis, leukocytes, steroids, therapeutic index, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3296-3302. doi:https://doi.org/10.1167/iovs.11-8114
Monitoring Morphological Changes in the Retina of Rhodopsin−/− Mice with Spectral Domain Optical Coherence Tomography Free
PDF
Ruilin Wang; Caihui Jiang; Jie Ma; Michael J. Young
Tags: electroretinography, mice, optical coherence tomography, retina, rhodopsin
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3967-3972. doi:https://doi.org/10.1167/iovs.12-9716

Visual Neuroscience

Myopic Children Have Central Reduction in High Contrast Multifocal ERG Response, While Adults Have Paracentral Reduction in Low Contrast Response Free
PDF
Wing-Cheung Ho; Chea-Su Kee; Henry Ho-Lung Chan
Tags: adult, child, electroretinography, refractive errors
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3695-3702. doi:https://doi.org/10.1167/iovs.11-9379

Visual Psychophysics and Physiological Optics

Optical Quality of Emmetropic and Myopic Eyes in the Periphery Measured with High-Angular Resolution Free
PDF
Bart Jaeken; Pablo Artal
Tags: eye, image quality, optics, refraction, myopia
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3405-3413. doi:https://doi.org/10.1167/iovs.11-8993
Near Work–Induced Contrast Adaptation in Emmetropic and Myopic Children Free
PDF
Anna C. H. Yeo; David A. Atchison; Nai S. Lai; Katrina L. Schmid
Tags: child, contrast sensitivity, myopia, reading (activity)
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3441-3448. doi:https://doi.org/10.1167/iovs.11-8959
Multifocal Intraocular Lens Differentiation Using Defocus Curves Free
PDF
Phillip J. Buckhurst; James S. Wolffsohn; Shehzad A. Naroo; Leon N. Davies; Gurpreet K. Bhogal; Athina Kipioti; Sunil Shah
Tags: intraocular lens implant device, vision, lens (device), myopia, lens, crystalline
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3920-3926. doi:https://doi.org/10.1167/iovs.11-9234

Clinical Trials

Adherence to Occlusion Therapy in the First Six Months of Follow-Up and Visual Acuity among Participants in the Infant Aphakia Treatment Study (IATS) Free
PDF
Carolyn D. Drews-Botsch; Marianne Celano; Stacey Kruger; E. Eugenie Hartmann; for the Infant Aphakia Treatment Study
Tags: aphakia, infant, occlusion therapy, visual acuity, follow-up
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3368-3375. doi:https://doi.org/10.1167/iovs.11-8457
Randomized Controlled Trial on the Effects of CCTV Training on Quality of Life, Depression, and Adaptation to Vision Loss Free
PDF
Marloes C. Burggraaff; Ruth M. A. van Nispen; Dirk L. Knol; Peter J. Ringens; Ger H. M. B. van Rens
Tags: blindness, closed circuit television, depressive disorders, quality of life, randomized controlled trial
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3645-3652. doi:https://doi.org/10.1167/iovs.11-9226
Oral Minocycline for the Treatment of Diabetic Macular Edema (DME): Results of a Phase I/II Clinical Study Free
PDF
Catherine A. Cukras; Philip Petrou; Emily Y. Chew; Catherine B. Meyerle; Wai T. Wong
Tags: diabetic macular edema, eye, minocycline, visual acuity
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3865-3874. doi:https://doi.org/10.1167/iovs.11-9413

Letters to the Editor

Author Response: Retinal Nerve Fiber Layer Thickness Measurements in Rats with the Spectral Domain Optical Coherence Tomography Free
PDF
Katharina Lange; Mathias Bähr; Katharina Hein
Tags: optical coherence tomography, rats, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3570-3571. doi:https://doi.org/10.1167/iovs.12-10024
Axonal Loss in a Rat Model of Optic Neuritis Is Closely Correlated with Visual Evoked Potential Amplitudes Using Electroencephalogram-based Scaling Free
PDF
Yuyi You; Alexander Klistorner; Johnson Thie; Vivek K. Gupta; Stuart L. Graham
Tags: electroencephalography, evoked potentials, visual, optic neuritis
Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3662. doi:https://doi.org/10.1167/iovs.12-9843
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Kathleen R. Pritchett-Corning; Charles B. Clifford; Bruce J. Elder; Mark Vezina
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Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3764-3765. doi:https://doi.org/10.1167/iovs.12-10056

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Investigative Ophthalmology & Visual Science June 2012, Vol.53, 3269. doi:https://doi.org/10.1167/iovs.11-8997a
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Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4139. doi:https://doi.org/10.1167/iovs.10-6579a
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Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4329. doi:https://doi.org/10.1167/iovs.12-9483da
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Investigative Ophthalmology & Visual Science June 2012, Vol.53, 4330. doi:https://doi.org/10.1167/iovs.11-7710a
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