Volume 54 Issue 13 | IOVS

Nonneuronal Control of the Differential Distribution of Myelin Along Retinal Ganglion Cell Axons in the Mouse Free

Xiaoli Yang; Haidong Zou; Gila Jung; Gisbert Richard; Stephan J. Linke; Marius Ader; Udo Bartsch

Tags: axon, mice, myelin, oligodendroglia, platelet-derived growth factor

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 7819-7827. doi:https://doi.org/10.1167/iovs.13-12596

Neural Crest Origin of Retinal and Choroidal Pericytes Free

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Andrea Trost; Falk Schroedl; Simona Lange; Francisco J. Rivera; Herbert Tempfer; Stefanie Korntner; Claus C. Stolt; Michael Wegner; Barbara Bogner; Alexandra Kaser-Eichberger; Karolina Krefft; Christian Runge; Ludwig Aigner; Herbert A. Reitsamer

Tags: neural crest, mice, pericytes, retina

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 7910-7921. doi:https://doi.org/10.1167/iovs.13-12946

Optic Nerve Inflammation and Demyelination in a Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy Free

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Bernard J. Slater; Fernandino L. Vilson; Yan Guo; Daniel Weinreich; Shelly Hwang; Steven L. Bernstein

Tags: demyelination, granulocyte-macrophage colony-stimulating factor, infarction, inflammation, nonarteritic anterior ischemic optic neuropathy

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 7952-7961. doi:https://doi.org/10.1167/iovs.13-12064

Optical Coherence Tomography as a Diagnostic Tool for Retinal Pathologies in Avian Ophthalmology Free

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Franziska Georgia Rauscher; Panagiotis Azmanis; Nicole Körber; Christian Koch; Jens Hübel; Wencke Vetterlein; Beatrice Werner; Jens Thielebein; Jens Dawczynski; Peter Wiedemann; Andreas Reichenbach; Mike Francke; Maria-Elisabeth Krautwald-Junghanns

Tags: aves, clinical diagnostic instrument, ophthalmology, optical coherence tomography, eye

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8259-8269. doi:https://doi.org/10.1167/iovs.13-11922

Biochemistry and Molecular Biology

Inhibition of Elastin Peptide-Mediated Angiogenic Signaling Mechanism(s) in Choroidal Endothelial Cells by the α6(IV)NC1 Collagen Fragment Free

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Venugopal Gunda; Raj Kumar Verma; Yakkanti Akul Sudhakar

Tags: 1-phosphatidylinositol 3-kinase, angiogenesis, collagen, elastin, endothelial cells

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 7828-7835. doi:https://doi.org/10.1167/iovs.12-10870

The Role of cGMP in Ocular Growth and the Development of Form-Deprivation Myopia in Guinea Pigs Free

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Fang Fang; Miaozhen Pan; Tingting Yan; Yijin Tao; Hao Wu; Xing Liu; Jia Qu; Xiangtian Zhou

Tags: cyclic gmp, eye, myopia, caviidae

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 7887-7902. doi:https://doi.org/10.1167/iovs.13-11999

Rapid Quantification of Free Cholesterol in Tears Using Direct Insertion/Electron Ionization–Mass Spectrometry Free

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Xiaojia Eric Wei; John Korth; Simon H. J. Brown; Todd W. Mitchell; Roger J. W. Truscott; Stephen J. Blanksby; Mark D. P. Willcox; Zhenjun Zhao

Tags: cholesterol, mass spectrometry, ionization

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8027-8035. doi:https://doi.org/10.1167/iovs.13-12786

Extremely Complex Populations of Small RNAs in the Mouse Retina and RPE/Choroid Free

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Sudha Priya Soundara Pandi; Mei Chen; Jasenka Guduric-Fuchs; Heping Xu; David Arthur Simpson

Tags: choroid, micrornas, retina, mice

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8140-8151. doi:https://doi.org/10.1167/iovs.13-12631

Nonselective Assembly of Fibrillin 1 and Fibrillin 2 in the Rodent Ocular Zonule and in Cultured Cells: Implications for Marfan Syndrome Free

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Lauren C. Beene; Lauren W. Wang; Dirk Hubmacher; Douglas R. Keene; Dieter P. Reinhardt; Douglas S. Annis; Deane F. Mosher; Robert P. Mecham; Elias I. Traboulsi; Suneel S. Apte

Tags: fibrillins, mice, rodentia, marfan syndrome

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8337-8344. doi:https://doi.org/10.1167/iovs.13-13121

Clinical and Epidemiologic Research

Long-Term Changes in Refractive Error in Children With Myopic Tilted Optic Disc Compared to Children Without Tilted Optic Disc Free

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Kyung-Ah Park; Sung-Eun Park; Sei Yeul Oh

Tags: child, refractive errors, tilted optic disc, myopia

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 7865-7870. doi:https://doi.org/10.1167/iovs.13-12987

Myopia Stabilization and Associated Factors Among Participants in the Correction of Myopia Evaluation Trial (COMET) Free

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Tags: myopia, stabilization, cohort studies

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 7871-7883. doi:https://doi.org/10.1167/iovs.13-12403

Determinants of Macular Thickness Using Spectral Domain Optical Coherence Tomography in Healthy Eyes: The Singapore Chinese Eye Study Free

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Preeti Gupta; Elizabeth Sidhartha; Yih Chung Tham; Daniel Kai Peng Chua; Jiemin Liao; Ching-Yu Cheng; Tin Aung; Tien Yin Wong; Carol Y. Cheung

Tags: chinese (other dialects), chinese people, eye, optical coherence tomography, singapore

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 7968-7976. doi:https://doi.org/10.1167/iovs.13-12436

Retinal Nerve Fiber Layer Thickness in Normal Chinese Students Aged 6 to 17 Years Free

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Li Chen; Jiannan Huang; Haidong Zou; Wenwen Xue; Yingyan Ma; Xiangui He; Lina Lu; Jianfeng Zhu

Tags: chinese (other dialects), chinese people, eye, retinal nerve fiber layer, student

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 7990-7997. doi:https://doi.org/10.1167/iovs.12-11252

Corneal Staining Characteristics in Limited Zones Compared With Whole Cornea Documentation for the Detection of Dry Eye Subtypes Free

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Beau J. Fenner; Louis Tong

Tags: cornea, dry eye syndromes

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8013-8019. doi:https://doi.org/10.1167/iovs.13-12802

Age-Related Change in Retinal Nerve Fiber Layer Thickness Measured With Spectral Domain Optical Coherence Tomography Free

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Ali Riza Cenk Celebi; G. Ertugrul Mirza

Tags: optical coherence tomography, retinal nerve fiber layer, nose

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8095-8103. doi:https://doi.org/10.1167/iovs.13-12634

Retinal Nerve Fiber Layer Thickness in a Population of 12-Year-Old Children in Central China Measured by iVue-100 Spectral-Domain Optical Coherence Tomography: The Anyang Childhood Eye St... Free

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Bi-Dan Zhu; Shi-Ming Li; He Li; Luo-Ru Liu; Yang Wang; Zhou Yang; Si-Yuan Li; Meng-Tian Kang; Jing Fu; Yan-Hua Qi; Si-Yan Zhan; Ningli Wang

Tags: child, china, eye, optical coherence tomography, retinal nerve fiber layer

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8104-8111. doi:https://doi.org/10.1167/iovs.13-11958

Screening for Retinopathy of Prematurity in China: A Neonatal Units–Based Prospective Study Free

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Yu Xu; Xiaohong Zhou; Qi Zhang; Xunda Ji; Qin Zhang; Jianxing Zhu; Chao Chen; Peiquan Zhao

Tags: china, infant, newborn, prospective studies, retinopathy of prematurity

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8229-8236. doi:https://doi.org/10.1167/iovs.13-12297

Cornea

A New Nanosecond UV Laser at 355 nm: Early Results of Corneal Flap Cutting in a Rabbit Model Free

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Andrea Trost; Falk Schrödl; Clemens Strohmaier; Barbara Bogner; Christian Runge; Alexandra Kaser-Eichberger; Karolina Krefft; Alfred Vogel; Norbert Linz; Sebastian Freidank; Andrea Hilpert; Inge Zimmermann; Günther Grabner; Herbert A. Reitsamer

Tags: 5-lipoxygenase-activating protein, cornea, lasers, surgical flaps, ultraviolet rays

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 7854-7864. doi:https://doi.org/10.1167/iovs.13-12580

Role of SH2-Containing Tyrosine Phosphatase Shp2 in Mouse Corneal Epithelial Stratification Free

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Gracia Y. Ng; Lung-Kun Yeh; Yujin Zhang; HongShan Liu; Gen-Sheng Feng; Winston W. Y. Kao; Chia-Yang Liu

Tags: cornea, corneal epithelium, epithelium, mice, morphogenesis

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 7933-7942. doi:https://doi.org/10.1167/iovs.13-12646

Comparison of Swollen and Dextran Deswollen Organ-Cultured Corneas for Descemet Membrane Dissection Preparation: Histological and Ultrastructural Findings Free

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Efdal Yoeruek; Johanna Hofmann; Karl-Ulrich Bartz-Schmidt

Tags: cornea, descemet's membrane, descemet's membrane endothelial keratoplasty, dextran, endothelial cells

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8036-8040. doi:https://doi.org/10.1167/iovs.13-12516

Tear Fluid Extracellular DNA: Diagnostic and Therapeutic Implications in Dry Eye Disease Free

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Sapna Tibrewal; Joy Sarkar; Sarmad H. Jassim; Sonal Gandhi; Snehal Sonawane; Shweta Chaudhary; Yong-Soo Byun; Yair Ivanir; Joelle Hallak; John H. Horner; Martin Newcomb; Sandeep Jain

Tags: dna, dry eye syndromes, dyes, eyedrops, fluorescence

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8051-8061. doi:https://doi.org/10.1167/iovs.13-12844

The Cornea in Classic Type Ehlers-Danlos Syndrome: Macro- and Microstructural Changes Free

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Edoardo Villani; Elena Garoli; Alessandra Bassotti; Fabrizio Magnani; Laura Tresoldi; Paolo Nucci; Roberto Ratiglia

Tags: cornea, ehlers-danlos syndrome, microscopy, confocal

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8062-8068. doi:https://doi.org/10.1167/iovs.13-12837

Detecting Human Papillomavirus in Ocular Surface Diseases Free

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Mark Woods; Sharron Chow; Benjamin Heng; Wendy Glenn; Noel Whitaker; Dale Waring; Jenna Iwasenko; William Rawlinson; Minas T. Coroneo; Denis Wakefield; Nick Di Girolamo

Tags: conjunctival neoplasms, dna, human papillomavirus, polymerase chain reaction, pterygium

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8069-8078. doi:https://doi.org/10.1167/iovs.13-13140

Enhanced Wound Healing, Kinase and Stem Cell Marker Expression in Diabetic Organ-Cultured Human Corneas Upon MMP-10 and Cathepsin F Gene Silencing Free

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Mehrnoosh Saghizadeh; Irina Epifantseva; David M. Hemmati; Chantelle A. Ghiam; William J. Brunken; Alexander V. Ljubimov

Tags: cathepsins, cornea, diabetes mellitus, endopeptidases, peptide hydrolases

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8172-8180. doi:https://doi.org/10.1167/iovs.13-13233

Triple Combination of siRNAs Targeting TGFβ1, TGFβR2, and CTGF Enhances Reduction of Collagen I and Smooth Muscle Actin in Corneal Fibroblasts Free

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Sriniwas Sriram; Paulette Robinson; Liya Pi; Alfred S. Lewin; Gregory Schultz

Tags: actins, cicatrix, collagen, connective tissue growth factor, cornea

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8214-8223. doi:https://doi.org/10.1167/iovs.13-12758

Evaluating the Association Between Keratoconus and the Corneal Thickness Genes in an Independent Australian Population Free

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Srujana Sahebjada; Maria Schache; Andrea J. Richardson; Grant Snibson; Stuart MacGregor; Mark Daniell; Paul N. Baird

Tags: cornea, genes, keratoconus, single nucleotide polymorphism, genotype determination

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8224-8228. doi:https://doi.org/10.1167/iovs.13-12982

Tear MMP-9 Levels as a Marker of Ocular Surface Inflammation in Conjunctivochalasis Free

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Arantxa Acera; Elena Vecino; Juan A. Duran

Tags: conjunctivochalasis, gelatinase b, inflammation, surgical procedures, operative, conjunctiva

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8285-8291. doi:https://doi.org/10.1167/iovs.13-12235

Tear Cytokine Profile as a Noninvasive Biomarker of Inflammation for Ocular Surface Diseases: Standard Operating Procedures Free

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Yi Wei; Neha Gadaria-Rathod; Seth Epstein; Penny Asbell

Tags: cytokine, standard operating procedure, biological markers, inflammation

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8327-8336. doi:https://doi.org/10.1167/iovs.13-12132

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Stress and Visual Function in Infantile Nystagmus Syndrome Free

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Philip H. Jones; Christopher M. Harris; J. Margaret Woodhouse; Tom H. Margrain; Fergal A. Ennis; Jonathan T. Erichsen

Tags: pathologic nystagmus, shock, stress, syndrome, vision

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 7943-7951. doi:https://doi.org/10.1167/iovs.13-12560

The Influence of Horizontal Convergence on Slow Oscillatory Eye Movements During Visual Fixation Free

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Bing Zhang; Roberto Bolzani; Gustaf Öqvist Seimyr; Jan Ygge; Tony Pansell

Tags: eye, eye movement, ocular fixation

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8091-8094. doi:https://doi.org/10.1167/iovs.13-12588

The Effect of Degrading Binocular Single Vision on Fine Visuomotor Skill Task Performance Free

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Marianne E. F. Piano; Anna R. O'Connor

Tags: lens (device), lens, crystalline, task performance and analysis, vision, water

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8204-8213. doi:https://doi.org/10.1167/iovs.12-10934

Eye Movement Alterations During Reading in Patients With Early Alzheimer Disease Free

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Gerardo Fernández; Pablo Mandolesi; Nora P. Rotstein; Oscar Colombo; Osvaldo Agamennoni; Luis E. Politi

Tags: alzheimer's disease, eye movement, reading (activity), saccades, sentences

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8345-8352. doi:https://doi.org/10.1167/iovs.13-12877

Global Motion Perception in 2-Year-Old Children: A Method for Psychophysical Assessment and Relationships With Clinical Measures of Visual Function Free

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Tzu-Ying Yu; Robert J. Jacobs; Nicola S. Anstice; Nabin Paudel; Jane E. Harding; Benjamin Thompson

Tags: child, motion, motion perception, vision, psychophysics

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8408-8419. doi:https://doi.org/10.1167/iovs.13-13051

Genetics

A Longitudinal Study of Stargardt Disease: Quantitative Assessment of Fundus Autofluorescence, Progression, and Genotype Correlations Free

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Kaoru Fujinami; Noemi Lois; Rajarshi Mukherjee; Vikki A. McBain; Kazushige Tsunoda; Kazuo Tsubota; Edwin M. Stone; Fred W. Fitzke; Catey Bunce; Anthony T. Moore; Andrew R. Webster; Michel Michaelides

Tags: atrophy, autofluorescence, follow-up, fundus autofluorescence imaging, genotype

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8181-8190. doi:https://doi.org/10.1167/iovs.13-12104

TNFRSF10A-LOC389641 rs13278062 But Not REST-C4orf14-POLR2B-IGFBP7 rs1713985 Was Found Associated With Age-Related Macular Degeneration in a Chinese Population Free

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Yaoyao Sun; Shanshan Li; Haiping Li; Fei Yang; Yujing Bai; Min Zhao; Jing Guo; Mingwei Zhao; Peng Zhou; Chiea Chuen Khor; Lvzhen Huang; Xiaoxin Li

Tags: age-related macular degeneration, chinese (other dialects), chinese people, meta-analysis

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8199-8203. doi:https://doi.org/10.1167/iovs.13-12867

Association of TLR2 Gene Polymorphisms With Ocular Behçet's Disease in a Chinese Han Population Free

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Jing Fang; Ranran Hu; Shengping Hou; Zi Ye; Qin Xiang; Jian Qi; Yan Zhou; Aize Kijlstra; Peizeng Yang

Tags: behcet syndrome, chinese (other dialects), genes, genotype, polymorphism

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8384-8392. doi:https://doi.org/10.1167/iovs.13-12878

Glaucoma

Anti-Connective Tissue Growth Factor Antibody Treatment Reduces Extracellular Matrix Production in Trabecular Meshwork and Lamina Cribrosa Cells Free

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Deborah M. Wallace; Abbot F. Clark; Kenneth E. Lipson; Darrell Andrews; John K. Crean; Colm J. O'Brien

Tags: antibodies, body tissue, connective tissue growth factor, cribriform plate, extracellular matrix

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 7836-7848. doi:https://doi.org/10.1167/iovs.13-12494

Choroidal Thickness in the Subtypes of Angle Closure: An EDI-OCT Study Free

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Wenbin Huang; Wei Wang; Xinbo Gao; Xingyi Li; Zheng Li; Minwen Zhou; Shida Chen; Xiulan Zhang

Tags: atrial premature complexes, choroid, diagnostic imaging, eye, intraocular pressure

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 7849-7853. doi:https://doi.org/10.1167/iovs.13-13158

Reduction of Steroid-Induced Intraocular Pressure Elevation in Sheep by Tissue Plasminogen Activator Free

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Rosana Gerometta; Sandeep Kumar; Shaily Shah; Larry Alvarez; Oscar Candia; John Danias

Tags: alteplase, intraocular pressure, sheep, steroids, eye

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 7903-7909. doi:https://doi.org/10.1167/iovs.13-12801

Differences in the Region- and Depth-Dependent Microstructural Organization in Normal Versus Glaucomatous Human Posterior Sclerae Free

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Forest L. Danford; Dongmei Yan; Robert A. Dreier; Thomas M. Cahir; Christopher A. Girkin; Jonathan P. Vande Geest

Tags: glaucoma, sclera, significance, surrogate endpoints

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 7922-7932. doi:https://doi.org/10.1167/iovs.13-12262

In Vivo Lamina Cribrosa Micro-Architecture in Healthy and Glaucomatous Eyes as Assessed by Optical Coherence Tomography Free

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Bo Wang; Jessica E. Nevins; Zach Nadler; Gadi Wollstein; Hiroshi Ishikawa; Richard A. Bilonick; Larry Kagemann; Ian A. Sigal; Ireneusz Grulkowski; Jonathan J. Liu; Martin Kraus; Chen D. Lu; Joachim Hornegger; James G. Fujimoto; Joel S. Schuman

Tags: cribriform plate, eye, glaucoma, microbiology procedures, optical coherence tomography

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8270-8274. doi:https://doi.org/10.1167/iovs.13-13109

Combining Spectral Domain Optical Coherence Tomography Structural Parameters for the Diagnosis of Glaucoma With Early Visual Field Loss Free

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Jean-Claude Mwanza; Joshua L. Warren; Donald L. Budenz

Tags: blindness, glaucoma, optical coherence tomography

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8393-8400. doi:https://doi.org/10.1167/iovs.13-12749

Factors Associated With Focal Lamina Cribrosa Defects in Glaucoma Free

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Sung Chul Park; Anthony T. Hsu; Daniel Su; Joseph L. Simonson; Mohammed Al-Jumayli; Yiyi Liu; Jeffrey M. Liebmann; Robert Ritch

Tags: cribriform plate, glaucoma, hemorrhage, eye

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8401-8407. doi:https://doi.org/10.1167/iovs.13-13014

Multidisciplinary Ophthalmic Imaging

Absolute Retinal Blood Flow Measurement With a Dual-Beam Doppler Optical Coherence Tomography Free

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Cuixia Dai; Xiaojing Liu; Hao F. Zhang; Carmen A. Puliafito; Shuliang Jiao

Tags: diagnostic imaging, fluid flow, optical coherence tomography, vascular flow, velocity

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 7998-8003. doi:https://doi.org/10.1167/iovs.13-12318

Morphology and Topography of Retinal Pericytes in the Living Mouse Retina Using In Vivo Adaptive Optics Imaging and Ex Vivo Characterization Free

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Jesse Schallek; Ying Geng; HoanVu Nguyen; David R. Williams

Tags: diagnostic imaging, language morphology, mice, morphology, optics

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8237-8250. doi:https://doi.org/10.1167/iovs.13-12581

Nantotechnology and Regenerative Medicine

Combination of Targeted PDT and Anti-VEGF Therapy for Rat CNV by RGD-Modified Liposomal Photocyanine and Sorafenib Free

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Jia-lin Wang; Yi Xi; Yu-ling Liu; Zhao-hui Wang; Qiang Zhang

Tags: anti-vascular endothelial growth factor therapy, choroidal neovascularization, liposomes, sorafenib

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 7983-7989. doi:https://doi.org/10.1167/iovs.13-13068

Physiology and Pharmacology

The Influence of Genetic Background on Conventional Outflow Facility in Mice Free

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Alexandra Boussommier-Calleja; Darryl R. Overby

Tags: genetics, intraocular pressure, mice, eye, mice, inbred c57bl

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8251-8258. doi:https://doi.org/10.1167/iovs.13-13025

Laser-Induced Intrachoroidal Dexamethasone Drug Delivery System to Posterior Eye Segment Free

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Masatoshi Murata; Atushi Sanbe; Jung Wha Lee; Hideo Nishigori

Tags: dexamethasone, drug delivery systems, implants, lasers, vitreous body

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8317-8324. doi:https://doi.org/10.1167/iovs.13-13078

Retina

Retinal Vascular Parameter Variations in Patients With Human Immunodeficiency Virus Free

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Petrina B. Tan; Owen K. Hee; Carol Cheung; Tun Kuan Yeo; Rupesh Agrawal; James Ng; Tock Han Lim; Tien Yin Wong; Stephen C. Teoh

Tags: hiv, retinal vasculature, fractals, retinal vascular caliber, viral load result

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 7962-7967. doi:https://doi.org/10.1167/iovs.13-13081

Progressive Myopia or Hyperopia Can Be Induced in Chicks and Reversed by Manipulation of the Chromaticity of Ambient Light Free

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Wallace S. Foulds; Veluchamy A. Barathi; Chi D. Luu

Tags: hyperopia, myopia, blue light

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8004-8012. doi:https://doi.org/10.1167/iovs.13-12476

Optical Coherence Tomographic Correlates of Angiographic Subtypes of Occult Choroidal Neovascularization Free

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Amirhossein Hariri; Florian M. Heussen; Muneeswar Gupta Nittala; SriniVas R. Sadda

Tags: angiogram, choroidal neovascularization, optical coherence tomography

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8020-8026. doi:https://doi.org/10.1167/iovs.13-12302

Roles of Cannabinoid Receptors Type 1 and 2 on the Retinal Function of Adult Mice Free

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Bruno Cécyre; Nawal Zabouri; Frédéric Huppé-Gourgues; Jean-François Bouchard; Christian Casanova

Tags: cannabinoid receptors, mice, retina, adult, electroretinography

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8079-8090. doi:https://doi.org/10.1167/iovs.13-12514

Systemic Inflammation Perturbs Developmental Retinal Angiogenesis and Neuroretinal Function Free

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Sophie Tremblay; Khalil Miloudi; Samaneh Chaychi; Sandra Favret; François Binet; Anna Polosa; Pierre Lachapelle; Sylvain Chemtob; Przemyslaw Sapieha

Tags: angiogenesis, inflammation, microglia, perinatal period, sepsis

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8125-8139. doi:https://doi.org/10.1167/iovs.13-12496

Is Handheld Optical Coherence Tomography Reliable in Infants and Young Children With and Without Nystagmus? Free

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Helena Lee; Frank Proudlock; Irene Gottlob

Tags: child, pathologic nystagmus, reliability, optical coherence tomography, infant

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8152-8159. doi:https://doi.org/10.1167/iovs.13-13230

Effect of Intravitreal Injection of Bevacizumab on Optic Nerve Head Leakage and Retinal Ganglion Cell Survival in a Mouse Model of Optic Nerve Crush Free

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Daniel Rappoport; Dana Morzaev; Shirel Weiss; Mark Vieyra; James D. Nicholson; Hana Leiba; Nitza Goldenberg-Cohen

Tags: bevacizumab, mice, optic nerve, optic disk, intravitreal injections

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8160-8171. doi:https://doi.org/10.1167/iovs.13-12771

Modulation of Retinal Müller Cells by Complement Receptor C5aR Free

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Lijia Cheng; Hong Bu; Jose-Andres C. Portillo; Yan Li; Carlos S. Subauste; Suber S. Huang; Timothy S. Kern; Feng Lin

Tags: complement receptors, complement system proteins, culture media, conditioned, hyperglycemia, interleukin-6

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8191-8198. doi:https://doi.org/10.1167/iovs.13-12428

Long-Term Neuroprotective Effects of NT-4–Engineered Mesenchymal Stem Cells Injected Intravitreally in a Mouse Model of Acute Retinal Injury Free

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Anna Machalińska; Miłosz Kawa; Ewa Pius-Sadowska; Jacek Stępniewski; Witold Nowak; Dorota Rogińska; Katarzyna Kaczyńska; Bartłomiej Baumert; Barbara Wiszniewska; Alicja Józkowicz; Józef Dulak; Bogusław Machaliński

Tags: genes, mesenchymal stem cells, mice, neuroprotective effect, retina

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8292-8305. doi:https://doi.org/10.1167/iovs.13-12221

Segmentation of the Geographic Atrophy in Spectral-Domain Optical Coherence Tomography and Fundus Autofluorescence Images Free

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Zhihong Hu; Gerard G. Medioni; Matthias Hernandez; Amirhossein Hariri; Xiaodong Wu; SriniVas R. Sadda

Tags: atrophy, fundus autofluorescence imaging, optical coherence tomography

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8375-8383. doi:https://doi.org/10.1167/iovs.13-12552

Retinal Cell Biology

Further Insights Into GPR179: Expression, Localization, and Associated Pathogenic Mechanisms Leading to Complete Congenital Stationary Night Blindness Free

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Elise Orhan; Laurent Prézeau; Said El Shamieh; Kinga M. Bujakowska; Christelle Michiels; Yvrick Zagar; Claire Vol; Shomi S. Bhattacharya; José-Alain Sahel; Florian Sennlaub; Isabelle Audo; Christina Zeitz

Tags: in situ hybridization, mice, mutation, night blindness, congenital stationary, proteins

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8041-8050. doi:https://doi.org/10.1167/iovs.13-12610

Thrombin Induces Epithelial-Mesenchymal Transition and Collagen Production by Retinal Pigment Epithelial Cells via Autocrine PDGF-Receptor Signaling Free

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Jeroen Bastiaans; Jan C. van Meurs; Conny van Holten-Neelen; Nicole M. A. Nagtzaam; P. Martin van Hagen; Rachel C. Chambers; Herbert Hooijkaas; Willem A. Dik

Tags: factor xa, platelet-derived growth factor receptor, thrombin, epithelial to mesenchymal transition, collagen synthesis

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8306-8314. doi:https://doi.org/10.1167/iovs.13-12383

Visual Neuroscience

Optical Coherence Tomography in the Diagnosis of Optic Pathway Gliomas Free

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Raffaele Parrozzani; Maurizio Clementi; Olympia Kotsafti; Giacomo Miglionico; Eva Trevisson; Gloria Orlando; Elisabetta Pilotto; Edoardo Midena

Tags: eye, glioma, optic disk, optical coherence tomography, retinal nerve fiber layer

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8112-8118. doi:https://doi.org/10.1167/iovs.13-13093

The Rat With Oxygen-Induced Retinopathy Is Myopic With Low Retinal Dopamine Free

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Nan Zhang; Tara L. Favazza; Anna Maria Baglieri; Ilan Y. Benador; Emily R. Noonan; Anne B. Fulton; Ronald M. Hansen; P. Michael Iuvone; James D. Akula

Tags: dopamine, eye, myopia, oxygen, retinal diseases

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8275-8284. doi:https://doi.org/10.1167/iovs.13-12544

Visual Psychophysics and Physiological Optics

A Study of the Short-Term Effect of Artificial Tears on Contrast Sensitivity in Patients With Sjögren's Syndrome Free

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Yuqiu Zhang; Richard Potvin; Lan Gong

Tags: contrast sensitivity, ocular lubricants, sjogren's syndrome, spatial frequency

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 7977-7982. doi:https://doi.org/10.1167/iovs.13-11798

Motion Perception and Driving: Predicting Performance Through Testing and Shortening Braking Reaction Times Through Training Free

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Luke Wilkins; Rob Gray; James Gaska; Marc Winterbottom

Tags: motion perception, reaction time, training, motion

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8364-8374. doi:https://doi.org/10.1167/iovs.13-12774

Perspective

A Perspective on the Role of the Extracellular Matrix in Progressive Retinal Degenerative Disorders Free

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Muayyad R. Al-Ubaidi; Muna I. Naash; Shannon M. Conley

Tags: degenerative disorders, extracellular matrix, retina, aging, gene therapy

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8119-8124. doi:https://doi.org/10.1167/iovs.13-13536

New Developments in Vision Research

Inhibition of Polo-Like Kinase 1 Promotes Hyperthermia Sensitivity via Inactivation of Heat Shock Transcription Factor 1 in Human Retinoblastoma Cells Free

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Tatsuya Yunoki; Yoshiaki Tabuchi; Atsushi Hayashi; Takashi Kondo

Tags: heat-shock response, hyperthermia, protein-serine-threonine kinases, retinoblastoma, rna, small interfering

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8353-8363. doi:https://doi.org/10.1167/iovs.13-12618

Letters to the Editor

RGC-5 Cells Free

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Neeraj Agarwal

Tags: cell lines, phenotype, retinal ganglion cells, calcium channels, phenotype determination

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 7884. doi:https://doi.org/10.1167/iovs.13-13292

Postural Changes of 24-Hour Intraocular Pressure in Normal-Tension Glaucoma Free

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Aparna Rao

Tags: intraocular pressure, low tension glaucoma

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8315. doi:https://doi.org/10.1167/iovs.13-13104

Author Response: Postural Changes of 24-Hour Intraocular Pressure in Normal Tension Glaucoma Free

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Rei Sakata; Makoto Araie

Tags: intraocular pressure, low tension glaucoma

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8316. doi:https://doi.org/10.1167/iovs.13-13602

Understanding RPE Lipofuscin Free

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Janet R. Sparrow; John E. Dowling; Dean Bok

Tags: comprehension, lipofuscin

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 8325-8326. doi:https://doi.org/10.1167/iovs.13-13214

Obituary

Remembering Bernard Becker, MD, 1920–2013 Free

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Paul L. Kaufman

Investigative Ophthalmology & Visual Science December 2013, Vol.54, 7885-7886. doi:https://doi.org/10.1167/iovs.13-13491

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