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Research Highlight

The Efficacy of Corneal Cross-Linking Shows a Sudden Decrease with Very High Intensity UV Light and Short Treatment Time Free
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Paolo Vinciguerra
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1181. doi:https://doi.org/10.1167/iovs.13-11666
What's in a Name? RPGR Mutations Redefine the Genetic and Phenotypic Landscape in Retinal Degenerative Diseases Free
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Anand Swaroop
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1417. doi:https://doi.org/10.1167/iovs.13-11750

Biochemistry and Molecular Biology

TGFβ Signaling Induces Expression of Gadd45b in Retinal Ganglion Cells Free
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Bin Liu; Xiaoguang Sun; Genn Suyeoka; Joe G. N. Garcia; Yannek I. Leiderman
Tags: retinal ganglion cells, signal transduction, wounds and injuries, rna, messenger, immunoblotting
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1061-1069. doi:https://doi.org/10.1167/iovs.12-10142
The Associations between Single Nucleotide Polymorphisms of DNA Repair Genes, DNA Damage, and Age-Related Cataract: Jiangsu Eye Study Free
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Shu Su; Yong Yao; Rongrong Zhu; Congkai Liang; Shengqun Jiang; Nan Hu; Jing Zhou; Mei Yang; Qian Xing; Huaijin Guan
Tags: cataract, senile, dna damage, dna repair, dna repair gene, eye
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1201-1207. doi:https://doi.org/10.1167/iovs.12-10940
Protein Phosphatase 2A Dephosphorylates CaBP4 and Regulates CaBP4 Function Free
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Françoise Haeseleer; Izabela Sokal; Frederick D. Gregory; Amy Lee
Tags: lysate, mice, phosphorylation, protein phosphatase, retina
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1214-1226. doi:https://doi.org/10.1167/iovs.12-11319
Variations in Opsin Coding Sequences Cause X-Linked Cone Dysfunction Syndrome with Myopia and Dichromacy Free
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Michelle McClements; Wayne I. L. Davies; Michel Michaelides; Terri Young; Maureen Neitz; Robert E. MacLaren; Anthony T. Moore; David M. Hunt
Tags: exons, family, genes, myopia, opsin
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1361-1369. doi:https://doi.org/10.1167/iovs.12-11156

Clinical and Epidemiologic Research

What Factors are Associated with Myopia in Young Adults? A Survey Study in Taiwan Military Conscripts Free
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Yin-Yang Lee; Chung-Ting Lo; Shwu-Jiuan Sheu; Julia L. Lin
Tags: myopia, surveys, taiwan, young adult, military personnel
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1026-1033. doi:https://doi.org/10.1167/iovs.12-10480
Distribution and Heritability of Peripheral Eye Length in Chinese Children and Adolescents: The Guangzhou Twin Eye Study Free
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Xiaohu Ding; Decai Wang; Qunxiao Huang; Jian Zhang; Jessica Chang; Mingguang He
Tags: adolescent, child, chinese (other dialects), chinese people, eye
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1048-1053. doi:https://doi.org/10.1167/iovs.12-10066
Quantification of Age-Related and per Diopter Accommodative Changes of the Lens and Ciliary Muscle in the Emmetropic Human Eye Free
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Kathryn Richdale; Loraine T. Sinnott; Mark A. Bullimore; Peter A. Wassenaar; Petra Schmalbrock; Chiu-Yen Kao; Samuel Patz; Donald O. Mutti; Adrian Glasser; Karla Zadnik
Tags: ciliary muscle, diopters, lens, crystalline, visual accommodation, lens (device)
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1095-1105. doi:https://doi.org/10.1167/iovs.12-10619
Impact of Glaucoma Severity and Laterality on Vision-Specific Functioning: The Singapore Malay Eye Study Free
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Errol W. Chan; Peggy P. C. Chiang; Tien Y. Wong; Seang M. Saw; Seng C. Loon; Tin Aung; Ecosse Lamoureux
Tags: eye, glaucoma, vision, singapore, handedness
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1169-1175. doi:https://doi.org/10.1167/iovs.12-10258
A Posteriori–Derived Dietary Patterns and Retinal Vessel Caliber in an Elderly Population Free
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Claire T. McEvoy; Christopher R. Cardwell; Usha Chakravarthy; Ruth E. Hogg; Michelle C. McKinley; Ian S. Young; Astrid E. Fletcher; Jayne V. Woodside
Tags: diet, older adult, retinal vascular caliber
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1337-1344. doi:https://doi.org/10.1167/iovs.12-11065
Ocular Surface Parameters in Older Male Veterans Free
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Anat Galor; William Feuer; David J. Lee; Hermes Florez; Vincent D. Venincasa; Victor L. Perez
Tags: signs and symptoms, tear film finding, veterans, cornea, study population
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1426-1433. doi:https://doi.org/10.1167/iovs.12-10819
The Association between Ocular Biometry and Retinal Vascular Caliber Is Comparable from Early Childhood to Adolescence Free
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Bamini Gopinath; Jie Jin Wang; Annette Kifley; Ava G. Tan; Tien Y. Wong; Paul Mitchell
Tags: biometry, child, retinal vascular caliber, adolescent, cornea
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1501-1508. doi:https://doi.org/10.1167/iovs.12-11036
10-Year Incidence and Associations of Pterygium in Adult Chinese: The Beijing Eye Study Free
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Liang Zhao; Qi Sheng You; Liang Xu; Ke Ma; Ya Xing Wang; Hua Yang; Jost B. Jonas
Tags: adult, chinese people, eye, incidence, pterygium
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1509-1514. doi:https://doi.org/10.1167/iovs.12-11183

Cornea

Influence of Aromatase Absence on the Gene Expression and Histology of the Mouse Meibomian Gland Free
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Raheleh Rahimi Darabad; Tomo Suzuki; Stephen M. Richards; Roderick V. Jensen; Frederick A. Jakobiec; Fouad R. Zakka; Shaohui Liu; David A. Sullivan
Tags: aromatase, gene expression, meibomian gland, mice, genes
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 987-998. doi:https://doi.org/10.1167/iovs.12-10992
Ultraviolet-A Irradiation Upregulated Urokinase-Type Plasminogen Activator in Pterygium Fibroblasts through ERK and JNK Pathways Free
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Shih-Chun Chao; Dan-Ning Hu; Pei-Yu Yang; Ching-Yang Lin; Chan-Wei Nien; Shun-Fa Yang; Joan E. Roberts
Tags: fibroblasts, pterygium, ultraviolet a radiation, urokinase
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 999-1007. doi:https://doi.org/10.1167/iovs.12-10469
Resistance of Corneal RFUVA–Cross-Linked Collagens and Small Leucine-Rich Proteoglycans to Degradation by Matrix Metalloproteinases Free
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Yuntao Zhang; Xiuli Mao; Tyler Schwend; Stacy Littlechild; Gary W. Conrad
Tags: catabolism, collagen, cornea, leucine, matrix metalloproteinases
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1014-1025. doi:https://doi.org/10.1167/iovs.12-11277
Dependability of Pachymetry Measurements after Myopic Advanced Surface Ablation Using Scanning-Slit Topography and Specular Microscopy Free
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Alberto López-Miguel; Loreto Martínez-Almeida; María Eugenia Mateo; María Begoña Coco-Martín; Jorge L. Alió; Miguel J. Maldonado
Tags: ablation, optical pachymetry, cornea
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1054-1060. doi:https://doi.org/10.1167/iovs.12-11015
The Efficacy of Corneal Cross-Linking Shows a Sudden Decrease with Very High Intensity UV Light and Short Treatment Time Free
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Jeremy Wernli; Silvia Schumacher; Eberhard Spoerl; Michael Mrochen
Tags: corneal collagen cross-linking, ultraviolet rays, light, lighting, cornea
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1176-1180. doi:https://doi.org/10.1167/iovs.12-11409
Keratoconus Diagnosis Using Anterior Segment Polarization-Sensitive Optical Coherence Tomography Free
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Shinichi Fukuda; Masahiro Yamanari; Yiheng Lim; Sujin Hoshi; Simone Beheregaray; Tetsuro Oshika; Yoshiaki Yasuno
Tags: keratoconus, optical coherence tomography, cornea
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1384-1391. doi:https://doi.org/10.1167/iovs.12-10979
A Novel Fluorescent Lipid Probe for Dry Eye: Retrieval by Tear Lipocalin in Humans Free
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Po-Ting Yeh; Richard Casey; Ben J. Glasgow
Tags: dry eye syndromes, lipids, proteins, fluorescein, tissue membrane
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1398-1410. doi:https://doi.org/10.1167/iovs.12-10817
Brillouin Microscopy of Collagen Crosslinking: Noncontact Depth-Dependent Analysis of Corneal Elastic Modulus Free
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Giuliano Scarcelli; Sabine Kling; Elena Quijano; Roberto Pineda; Susana Marcos; Seok Hyun Yun
Tags: cornea, corneal collagen cross-linking
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1418-1425. doi:https://doi.org/10.1167/iovs.12-11387
Moxifloxacin Susceptibility Mediates the Relationship between Causative Organism and Clinical Outcome in Bacterial Keratitis Free
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Catherine E. Oldenburg; Prajna Lalitha; Muthiah Srinivasan; Palanisamy Manikandan; M. Jayahar Bharathi; Revathi Rajaraman; Meenakshi Ravindran; Jeena Mascarenhas; Natalie Nardone; Kathryn J. Ray; David V. Glidden; Nisha R. Acharya; Thomas M. Lietman
Tags: bacterial keratitis, disease susceptibility, moxifloxacin, treatment outcome
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1522-1526. doi:https://doi.org/10.1167/iovs.12-11246
Toll-Like Receptor Expression and Activation in Mice with Experimental Dry Eye Free
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Rachel L. Redfern; Nimesh Patel; Samuel Hanlon; William Farley; Margaret Gondo; Stephen C. Pflugfelder; Alison M. McDermott
Tags: agonists, dry eye syndromes, mice, toll-like receptor, rna, messenger
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1554-1563. doi:https://doi.org/10.1167/iovs.12-10739

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Feasibility and Comparison of Visual Acuity Testing Methods in Children with Neurofibromatosis Type 1 and/or Optic Pathway Gliomas Free
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Robert A. Avery; Eric Bouffet; Roger J. Packer; Arun Reginald
Tags: child, eye, glioma, neurofibromatoses, neurofibromatosis 1
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1034-1038. doi:https://doi.org/10.1167/iovs.12-11385
Estimation of Spontaneous Blinking Main Sequence in Normal Subjects and Patients with Graves' Upper Eyelid Retraction Free
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Denny M. Garcia; José Carlos Barbosa; Carolina T. Pinto; Antonio Augusto V. Cruz
Tags: blinking, retraction of eyelid, velocity, linear regression
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1434-1442. doi:https://doi.org/10.1167/iovs.12-11452

Genetics

Identification of a Candidate Gene for Astigmatism Free
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Margarida C. Lopes; Pirro G. Hysi; Virginie J. M. Verhoeven; Stuart Macgregor; Alex W. Hewitt; Grant W. Montgomery; Phillippa Cumberland; Johannes R. Vingerling; Terri L. Young; Cornelia M. van Duijn; Ben Oostra; Andre G. Uitterlinden; Jugnoo S. Rahi; David A. Mackey; Caroline C. W. Klaver; Toby Andrew; Christopher J. Hammond
Tags: astigmatism, cohort studies, candidate disease gene
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1260-1267. doi:https://doi.org/10.1167/iovs.12-10463
Mutations in the X-Linked Retinitis Pigmentosa Genes RPGR and RP2 Found in 8.5% of Families with a Provisional Diagnosis of Autosomal Dominant Retinitis Pigmentosa Free
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Jennifer D. Churchill; Sara J. Bowne; Lori S. Sullivan; Richard Alan Lewis; Dianna K. Wheaton; David G. Birch; Kari E. Branham; John R. Heckenlively; Stephen P. Daiger
Tags: family, genes, mutation, retinitis pigmentosa, x-linked inheritance
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1411-1416. doi:https://doi.org/10.1167/iovs.12-11541

Glaucoma

Morphology of Astrocytes in a Glaucomatous Optic Nerve Free
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Ming Lye-Barthel; Daniel Sun; Tatjana C. Jakobs
Tags: astrocytes, glaucoma, optic nerve, language morphology, morphology
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 909-917. doi:https://doi.org/10.1167/iovs.12-10109
Analyzing Live Cellularity in the Human Trabecular Meshwork Free
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Jose M. Gonzalez, Jr; Sarah Hamm-Alvarez; James C. H. Tan
Tags: body tissue, cell nucleus, cytosol, donors, dyes
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1039-1047. doi:https://doi.org/10.1167/iovs.12-10479
Sustained Ocular Hypertension Induces Dendritic Degeneration of Mouse Retinal Ganglion Cells That Depends on Cell Type and Location Free
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Liang Feng; Yan Zhao; Miho Yoshida; Hui Chen; Jessica F. Yang; Ted S. Kim; Jianhua Cang; John B. Troy; Xiaorong Liu
Tags: dendrites, eye, glaucoma, intraocular pressure, lasers
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1106-1117. doi:https://doi.org/10.1167/iovs.12-10791
The Effect of Rho-Associated Kinase Inhibition on the Ocular Penetration of Timolol Maleate Free
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John J. Arnold; Mark S. Hansen; Gregory S. Gorman; Toshihiro Inoue; Vasantha Rao; Simone Spellen; Ronald N. Hunsinger; Christopher A. Chapleau; Lucas Pozzo-Miller; W. Daniel Stamer; Pratap Challa
Tags: phosphotransferases, timolol, eye injuries, penetrating, conjunctiva, body tissue
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1118-1126. doi:https://doi.org/10.1167/iovs.12-10583
Expansion of Schlemm's Canal by Travoprost in Healthy Subjects Determined by Fourier-Domain Optical Coherence Tomography Free
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Junyi Chen; Haili Huang; Shenghai Zhang; Xueli Chen; Xinghuai Sun
Tags: optical coherence tomography, schlemm's canal, travoprost, eye, placebos
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1127-1134. doi:https://doi.org/10.1167/iovs.12-10396
Photopic Negative Response versus Pattern Electroretinogram in Early Glaucoma Free
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Dunja Preiser; Wolf A. Lagrèze; Michael Bach; Charlotte M. Poloschek
Tags: electroretinography, glaucoma
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1182-1191. doi:https://doi.org/10.1167/iovs.12-11201
Global and Pointwise Rates of Decay in Glaucoma Eyes Deteriorating according to Pointwise Event Analysis Free
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Nariman Nassiri; Sasan Moghimi; Anne L. Coleman; Simon K. Law; Joseph Caprioli; Kouros Nouri-Mahdavi
Tags: eye, glaucoma, visual fields, trend
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1208-1213. doi:https://doi.org/10.1167/iovs.12-10833
Series Length Used during Trend Analysis Affects Sensitivity to Changes in Progression Rate in the Ocular Hypertension Treatment Study Free
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Stuart K. Gardiner; Shaban Demirel; Carlos Gustavo De Moraes; Jeffrey M. Liebmann; George A. Cioffi; Robert Ritch; Mae O. Gordon; Michael A. Kass; for the Ocular Hypertension Treatment Study Group
Tags: eye, ocular hypertension, trend, universities, ophthalmology
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1252-1259. doi:https://doi.org/10.1167/iovs.12-10218
Triamcinolone Acetonide Decreases Outflow Facility in C57BL/6 Mouse Eyes Free
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Sandeep Kumar; Shaily Shah; Emily Rose Deutsch; Hai Michael Tang; John Danias
Tags: eye, mice, mice, inbred c57bl, steroids, triamcinolone acetonide
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1280-1287. doi:https://doi.org/10.1167/iovs.12-11223
The Repeatability of Mean Defect with Size III and Size V Standard Automated Perimetry Free
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Michael Wall; Carrie K. Doyle; K. D. Zamba; Paul Artes; Chris A. Johnson
Tags: glaucoma, perimetry, visual fields, confidence limits
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1345-1351. doi:https://doi.org/10.1167/iovs.12-10299
Stem Cells from Trabecular Meshwork Home to TM Tissue In Vivo Free
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Yiqin Du; Hongmin Yun; Enzhi Yang; Joel S. Schuman
Tags: anterior chamber of eye, body tissue, fibroblasts, mice, stem cells
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1450-1459. doi:https://doi.org/10.1167/iovs.12-11056
Spatial Modeling of Visual Field Data for Assessing Glaucoma Progression Free
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Brigid D. Betz-Stablein; William H. Morgan; Philip H. House; Martin L. Hazelton
Tags: eye, glaucoma, visual fields
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1544-1553. doi:https://doi.org/10.1167/iovs.12-11226

Immunology and Microbiology

Delivery of Herpes Simplex Virus to Retinal Ganglion Cell Axon Is Dependent on Viral Protein Us9 Free
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Jolene M. Draper; Guiqing Huang; Graham S. Stephenson; Andrea S. Bertke; Daniel A. Cortez; Jennifer H. LaVail
Tags: axon, dna, dna, viral, proteins, retinal ganglion cells
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 962-967. doi:https://doi.org/10.1167/iovs.12-11274
A Cationic Peptide, TAT-Cd0, Inhibits Herpes Simplex Virus Type 1 Ocular Infection In Vivo Free
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Gilbert G. Jose; Inna V. Larsen; Joshua Gauger; Erica Carballo; Rebecca Stern; Rachel Brummel; Curtis R. Brandt
Tags: human herpesvirus 1, mice, peptides, eye infections
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1070-1079. doi:https://doi.org/10.1167/iovs.12-10250
MRP8/14 Enhances Corneal Susceptibility to Pseudomonas aeruginosa Infection by Amplifying Inflammatory Responses Free
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Qiuchan Deng; Mingxia Sun; Kun Yang; Min Zhu; Kang Chen; Jin Yuan; Minhao Wu; Xi Huang
Tags: cornea, disease susceptibility, infections, inflammatory response, keratitis
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1227-1234. doi:https://doi.org/10.1167/iovs.12-10172
Broad-Spectrum Virucidal Activity of (NVC-422) N,N-dichloro-2,2-dimethyltaurine against Viral Ocular Pathogens In Vitro Free
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Andreas Jekle; Suriani Abdul Rani; Chris Celeri; Meghan Zuck; Ping Xu; Lu Wang; Kathryn Najafi-Tagol; Mark Anderson; David Stroman; Dmitri Debabov
Tags: acetates, adenoviruses, coxsackie viruses, enterovirus 70, human herpesvirus 1
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1244-1251. doi:https://doi.org/10.1167/iovs.12-10700

Lens

Copy Number Variations of DNA Repair Genes and the Age-Related Cataract: Jiangsu Eye Study Free
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Jin Jiang; Jing Zhou; Yong Yao; Rongrong Zhu; Congkai Liang; Shengqun Jiang; Mei Yang; Yixiang Lu; Qian Xing; Huaijin Guan
Tags: cataract, senile, copy number polymorphism, dna, dna repair, dna repair gene
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 932-938. doi:https://doi.org/10.1167/iovs.12-10948
Proteomics and Phosphoproteomics Analysis of Human Lens Fiber Cell Membranes Free
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Zhen Wang; Jun Han; Larry L. David; Kevin L. Schey
Tags: cell membrane, lens (device), lens, crystalline, proteins, proteomics
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1135-1143. doi:https://doi.org/10.1167/iovs.12-11168

Low Vision

Evaluation of a Vision-Related Utility Instrument: The German Vision and Quality of Life Index Free
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Robert P. Finger; Karsten Kortuem; Eva Fenwick; Bettina von Livonius; Jill E. Keeffe; Christoph W. Hirneiss
Tags: german, quality of life, vision, visual impairment, rasch model
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1289-1294. doi:https://doi.org/10.1167/iovs.12-10828

Physiology and Pharmacology

Intraocular Hemorrhage Causes Retinal Vascular Dysfunction via Plasma Kallikrein Free
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Jia Liu; Allen C. Clermont; Ben-Bo Gao; Edward P. Feener
Tags: collagen, eye, eye hemorrhage, hemorrhage, intravitreal injections
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1086-1094. doi:https://doi.org/10.1167/iovs.12-10537
Disruption and Destabilization of Meibomian Lipid Films Caused by Increasing Amounts of Ceramides and Cholesterol Free
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Juan C. Arciniega; Eduardo Uchiyama; Igor A. Butovich
Tags: lipids, comparative effectiveness research, cholesterol, ceramides
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1352-1360. doi:https://doi.org/10.1167/iovs.12-10662
Na+-Independent Nucleoside Transporters Regulate Adenosine and Hypoxanthine Levels in Müller Cells and the Inner Blood–Retinal Barrier Free
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Shin-ichi Akanuma; Tatsuya Soutome; Eikichi Hisada; Masanori Tachikawa; Yoshiyuki Kubo; Ken-ichi Hosoya
Tags: adenosine, hypoxanthine, membrane transport proteins, nucleosides, blood-retinal barrier
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1469-1477. doi:https://doi.org/10.1167/iovs.12-10905
Assessing a Novel Depot Delivery Strategy for Noninvasive Administration of VEGF/PDGF RTK Inhibitors for Ocular Neovascular Disease Free
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Scott J. Robbie; Peter Lundh von Leithner; Meihua Ju; Clemens A. Lange; Andrew G. King; Peter Adamson; Dennis Lee; Caroline Sychterz; Pete Coffey; Yin-Shan Ng; James W. Bainbridge; David T. Shima
Tags: choroidal neovascularization, melanins, pazopanib, platelet-derived growth factor, uvea
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1490-1500. doi:https://doi.org/10.1167/iovs.12-10169

Retina

High-Resolution Images of Retinal Structure in Patients with Choroideremia Free
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Reema Syed; Sanna M. Sundquist; Kavitha Ratnam; Shiri Zayit-Soudry; Yuhua Zhang; J. Brooks Crawford; Ian M. MacDonald; Pooja Godara; Jungtae Rha; Joseph Carroll; Austin Roorda; Kimberly E. Stepien; Jacque L. Duncan
Tags: choroideremia, retina, retinal cone, mosaicism, tissue degeneration
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 950-961. doi:https://doi.org/10.1167/iovs.12-10707
Effect of Brain-Derived Neurotrophic Factor on Mouse Axotomized Retinal Ganglion Cells and Phagocytic Microglia Free
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Caridad Galindo-Romero; F. Javier Valiente-Soriano; M. Jiménez-López; Diego García-Ayuso; Maria P. Villegas-Pérez; Manuel Vidal-Sanz; Marta Agudo-Barriuso
Tags: brain-derived neurotrophic factor, mice, microglia, retina, retinal ganglion cells
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 974-985. doi:https://doi.org/10.1167/iovs.12-11207
The Relationship between Foveal Ischemia and Spectral-Domain Optical Coherence Tomography Findings in Ischemic Diabetic Macular Edema Free
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Dong-Hoon Lee; Jee Taek Kim; Da-Woon Jung; Soo Geun Joe; Young Hee Yoon
Tags: diabetic macular edema, ischemia, optical coherence tomography, hypertrophy
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1080-1085. doi:https://doi.org/10.1167/iovs.12-10503
Juxtapapillary Pigment Epithelium Detachment Observed in Asymptomatic Participants Using Optical Coherence Tomography Free
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Yanling Ouyang; Florian M. Heussen; Pearse A. Keane; Rajeev K. R. Pappuru; SriniVas R. Sadda; Alexander C. Walsh
Tags: drusen, epithelium, eye, optical coherence tomography, pigment
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1144-1149. doi:https://doi.org/10.1167/iovs.12-9903
Oxidized Porous Silicon Particles Covalently Grafted with Daunorubicin as a Sustained Intraocular Drug Delivery System Free
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Jay Chhablani; Alejandra Nieto; Huiyuan Hou; Elizabeth C. Wu; William R. Freeman; Michael J. Sailor; Lingyun Cheng
Tags: daunorubicin, silicon, drug delivery systems
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1268-1279. doi:https://doi.org/10.1167/iovs.12-11172
Macular Bruch's Membrane Defects and Axial Length: Association with Gamma Zone and Delta Zone in Peripapillary Region Free
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Jost B. Jonas; Kyoko Ohno-Matsui; Richard F. Spaide; Leonard Holbach; Songhomitra Panda-Jonas
Tags: bruch's basal membrane, eye, myopia, optic disk
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1295-1302. doi:https://doi.org/10.1167/iovs.12-11352
Correlations between Spectral-Domain OCT Measurements and Visual Acuity in Cystoid Macular Edema Associated with Retinitis Pigmentosa Free
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Yoon Jeon Kim; Soo Geun Joe; Dong-Hoon Lee; Joo Yong Lee; June-Gone Kim; Young Hee Yoon
Tags: education, medical, continuing, eye, macular edema, cystoid, retinitis pigmentosa, visual acuity
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1303-1309. doi:https://doi.org/10.1167/iovs.12-10149
Correlation of OCT Characteristics and Retinal Sensitivity in Neovascular Age-Related Macular Degeneration in the Course of Monthly Ranibizumab Treatment Free
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Florian Sulzbacher; Christopher Kiss; Alexandra Kaider; Philipp Roberts; Marion Munk; Maria Elisabeth Kroh; Ramzi Sayegh; Ursula Schmidt-Erfurth
Tags: exudative age-related macular degeneration, ranibizumab
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1310-1315. doi:https://doi.org/10.1167/iovs.12-11046
Auditory Force Feedback Substitution Improves Surgical Precision during Simulated Ophthalmic Surgery Free
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Nathan Cutler; Marcin Balicki; Mark Finkelstein; Jiangxia Wang; Peter Gehlbach; John McGready; Iulian Iordachita; Russell Taylor; James T. Handa
Tags: feedback, manganese, ophthalmologic surgical procedures, precision, surgical procedures, operative
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1316-1324. doi:https://doi.org/10.1167/iovs.12-11136
Early Visual Deficits in Streptozotocin-Induced Diabetic Long Evans Rats Free
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Moe H. Aung; Moon K. Kim; Darin E. Olson; Peter M. Thule; Machelle T. Pardue
Tags: cataract, diabetes mellitus, streptozocin, vision, visual impairment
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1370-1377. doi:https://doi.org/10.1167/iovs.12-10927
Intervisit Variability of Visual Parameters in Leber Congenital Amaurosis Caused by RPE65 Mutations Free
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Alejandro J. Roman; Artur V. Cideciyan; Sharon B. Schwartz; Melani B. Olivares; Elise Heon; Samuel G. Jacobson
Tags: kinetics, leber's amaurosis, mutation, vision, visual fields
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1378-1383. doi:https://doi.org/10.1167/iovs.12-11341
Dilation of Porcine Retinal Arterioles to Cilostazol: Roles of eNOS Phosphorylation via cAMP/Protein Kinase A and AMP-Activated Protein Kinase and Potassium Channels Free
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Ichiro Tanano; Taiji Nagaoka; Tsuneaki Omae; Akihiro Ishibazawa; Takayuki Kamiya; Shinji Ono; Akitoshi Yoshida
Tags: arteriole, cilostazol, dilatation, pathologic, nitric oxide synthase, potassium channel
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1443-1449. doi:https://doi.org/10.1167/iovs.12-10115
The Retinal Disease Screening Study: Prospective Comparison of Nonmydriatic Fundus Photography and Optical Coherence Tomography for Detection of Retinal Irregularities Free
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Yanling Ouyang; Florian M. Heussen; Pearse A. Keane; SriniVas R. Sadda; Alexander C. Walsh
Tags: eye, fundus photography, optical coherence tomography, retinal diseases, screening
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1460-1468. doi:https://doi.org/10.1167/iovs.12-10727
Amyloid-β Increases Capillary Bed Density in the Adult Zebrafish Retina Free
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Khomthorn Cunvong; Daniel Huffmire; Douglas W. Ethell; D. Joshua Cameron
Tags: adult, amyloid, capillary bed, retina, zebrafish
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1516-1521. doi:https://doi.org/10.1167/iovs.12-10821
Loss of Scotopic Contrast Sensitivity in the Optomotor Response of Diabetic Mice Free
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Yumiko Umino; Eduardo Solessio
Tags: contrast sensitivity, diabetes mellitus, mice
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1536-1543. doi:https://doi.org/10.1167/iovs.12-10825

Retinal Cell Biology

Hyperoxia Causes Regression of Vitreous Neovascularization by Downregulating VEGF/VEGFR2 Pathway Free
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Hua Liu; Wenbo Zhang; Zhimin Xu; Robert W. Caldwell; Ruth B. Caldwell; Steven E. Brooks
Tags: hyperoxia, neovascularization, pathologic, vascular endothelial growth factor a, vascular endothelial growth factor receptor-2, vitreous body
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 918-931. doi:https://doi.org/10.1167/iovs.12-11291
Alterations of Retinal Vasculature in Cystathionine-Beta-Synthase Mutant Mice, a Model of Hyperhomocysteinemia Free
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Amany Tawfik; Mohamed Al-Shabrawey; Penny Roon; Srinivas Sonne; Jason A. Covar; Surapoon Matragoon; Preethi S. Ganapathy; Sally S. Atherton; Azza El-Remessy; Vadivel Ganapathy; Sylvia B. Smith
Tags: cystathionine beta-synthase, hyperhomocysteinemia, mice, retina, retinal vasculature
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 939-949. doi:https://doi.org/10.1167/iovs.12-10536
Inhibition of PVR with a Tyrosine Kinase Inhibitor, Dasatinib, in the Swine Free
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Kazuhiko Umazume; LanHsin Liu; Patrick A. Scott; Juan P. Fernandez de Castro; Kevin McDonald; Henry J. Kaplan; Shigeo Tamiya
Tags: dasatinib, protein-tyrosine kinase inhibitor, suidae, retinal pigment cell
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1150-1159. doi:https://doi.org/10.1167/iovs.12-10418
Green Tea Is Neuroprotective in Diabetic Retinopathy Free
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Kamila C. Silva; Mariana A. B. Rosales; Dania E. Hamassaki; Kelly C. Saito; Aline M. Faria; Patrícia A. O. Ribeiro; José B. Lopes de Faria; Jacqueline M. Lopes de Faria
Tags: diabetes mellitus, retina, diabetic retinopathy, green tea, neuroprotection
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1325-1336. doi:https://doi.org/10.1167/iovs.12-10647
Suppression of Laser-Induced Choroidal Neovascularization by a CCR3 Antagonist Free
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Takeshi Mizutani; Masayuki Ashikari; Mayumi Tokoro; Miho Nozaki; Yuichiro Ogura
Tags: antagonists, choroidal neovascularization, lasers, vascular endothelial growth factor a, laser injuries
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1564-1572. doi:https://doi.org/10.1167/iovs.11-9095

Translational

Molecular Histopathology Using Gold Nanorods and Optical Coherence Tomography Free
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Shradha Prabhulkar; Jared Matthews; Siddarth Rawal; Richard M. Awdeh
Tags: gold, histopathology tests, optical coherence tomography, body tissue, diagnostic imaging
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1192-1200. doi:https://doi.org/10.1167/iovs.12-10794
SU9518 Inhibits Proliferative Vitreoretinopathy in Fibroblast and Genetically Modified Müller Cell–Induced Rabbit Models Free
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Gisela Velez; Alexa R. Weingarden; Hetian Lei; Andrius Kazlauskas; Guangping Gao
Tags: fibroblasts, oryctolagus cuniculus, vitreoretinopathy, proliferative, eye
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1392-1397. doi:https://doi.org/10.1167/iovs.12-10320

Visual Neuroscience

Retrograde Signaling in the Optic Nerve Is Necessary for Electrical Responsiveness of Retinal Ganglion Cells Free
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Tsung-Han Chou; Kevin K. Park; Xueting Luo; Vittorio Porciatti
Tags: axon, biological transport, lidocaine, optic nerve, retinal ganglion cells
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1236-1243. doi:https://doi.org/10.1167/iovs.12-11188
Oral Proton Pump Inhibitors Disrupt Horizontal Cell-Cone Feedback and Enhance Visual Hallucinations in Macular Degeneration Patients Free
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Anne M. Hanneken; Norbert Babai; Wallace B. Thoreson
Tags: feedback, hallucinations, visual, macular degeneration, proton pump inhibitors, retinal cone
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1485-1489. doi:https://doi.org/10.1167/iovs.12-11091

Visual Psychophysics and Physiological Optics

Global Shape Processing Deficits Are Amplified by Temporal Masking in Migraine Free
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Doreen Wagner; Velitchko Manahilov; Gael E. Gordon; Gunter Loffler
Tags: masks, migraine disorders, perceptual masking
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1160-1168. doi:https://doi.org/10.1167/iovs.12-11242
Effect of Text Type on Near Work–Induced Contrast Adaptation in Myopic and Emmetropic Young Adults Free
PDF
Anna C. H. Yeo; David A. Atchison; Katrina L. Schmid
Tags: chinese (other dialects), chinese people, english, reading (activity), young adult
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1478-1483. doi:https://doi.org/10.1167/iovs.12-11496
Higher Order Aberrations in Children with Down Syndrome Free
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Sara J. McCullough; Julie-Anne Little; Kathryn J. Saunders
Tags: child, down syndrome, refractive errors, pupil, eye
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1527-1535. doi:https://doi.org/10.1167/iovs.12-10597
Peripheral Refractive Changes Associated with Myopia Progression Free
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Hema Radhakrishnan; Peter M. Allen; Richard I. Calver; Baskar Theagarayan; Holly Price; Sheila Rae; Ananth Sailoganathan; Daniel J. O'Leary
Tags: myopia, refraction, refractive errors, retina, nose
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1573-1581. doi:https://doi.org/10.1167/iovs.12-10278

Clinical Trials

Effectiveness of Palmitoylethanolamide on Endothelial Dysfunction in Ocular Hypertensive Patients: A Randomized, Placebo-Controlled Cross-Over Study Free
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Ernesto Strobbe; Mauro Cellini; Emilio C. Campos
Tags: endothelial dysfunction, intraocular pressure, ocular hypertension, placebos, endothelium
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 968-973. doi:https://doi.org/10.1167/iovs.12-10899
Measurement of Retinal Oxygen Saturation in Patients with Chronic Obstructive Pulmonary Disease Free
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Stefan Palkovits; Michael Lasta; Agnes Boltz; Doreen Schmidl; Semira Kaya; Martin Hammer; Beatrice Marzluf; Alina Popa-Cherecheanu; Sophie Frantal; Leopold Schmetterer; Gerhard Garhöfer
Tags: arterial oxygen saturation, chronic obstructive airway disease, oxygen saturation measurement, oxygen, oximetry, pulse
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1008-1013. doi:https://doi.org/10.1167/iovs.12-10504

Letters to the Editor

Author Response: Retinal Microglia Free
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Shu Liu; Christopher Leung
Tags: microglia
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1235. doi:https://doi.org/10.1167/iovs.13-11589
Estimation of Hemoglobin Levels in the Optic Nerve Head for Glaucoma Management Free
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Jonathan Denniss
Tags: glaucoma, hemoglobin measurement, optic disk
Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1515. doi:https://doi.org/10.1167/iovs.13-11767

Erratum

Erratum Free
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Investigative Ophthalmology & Visual Science February 2013, Vol.54, 986. doi:https://doi.org/10.1167/iovs.12-10648a
Erratum Free
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Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1288. doi:https://doi.org/10.1167/iovs.11-8968a
Erratum Free
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Investigative Ophthalmology & Visual Science February 2013, Vol.54, 1484. doi:https://doi.org/10.1167/iovs.11-8702a
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