Volume 54 Issue 7 | IOVS

Research Highlight

Staphylococcus aureus Keratitis and Panton-Valentine Leukocidin Free

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Stephen Kaye

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4439. doi:https://doi.org/10.1167/iovs.13-12515

Contributing Factors to Corneal Deformation in Air Puff Measurements Free

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Farhad Hafezi

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 5086. doi:https://doi.org/10.1167/iovs.13-12747

Biochemistry and Molecular Biology

Photoreceptor-Like Cells in Transgenic Mouse Eye Free

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Run-Tao Yan; Xiumei Li; Shu-Zhen Wang

Tags: eye, mammals, mice, mice, transgenic, photoreceptors

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4766-4775. doi:https://doi.org/10.1167/iovs.13-11936

Regulation of iNOS Expression by NF-κB in Human Lens Epithelial Cells Treated With High Levels of Glucose Free

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Jinhai Jia; Yuan Liu; Xiaolin Zhang; Xinke Liu; Jinsheng Qi

Tags: glucose, nitric oxide synthase

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 5070-5077. doi:https://doi.org/10.1167/iovs.13-11796

Complementation Test of Rpe65 Knockout and Tvrm148 Free

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Charles B. Wright; Micah A. Chrenek; Stephanie L. Foster; Todd Duncan; T. Michael Redmond; Machelle T. Pardue; Jeffrey H. Boatright; John M. Nickerson

Tags: genetic complementation test, mice, mutation, proteins, retinoids

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 5111-5122. doi:https://doi.org/10.1167/iovs.13-12336

Clinical and Epidemiologic Research

Myopia, Axial Length, and Age-Related Cataract: The Singapore Malay Eye Study Free

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Chen-Wei Pan; Pui Yi Boey; Ching-Yu Cheng; Seang-Mei Saw; Wan Ting Tay; Jie Jin Wang; Ava Grace Tan; Paul Mitchell; Tien Yin Wong

Tags: cataract, cataract, senile, eye, myopia, singapore

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4498-4502. doi:https://doi.org/10.1167/iovs.13-12271

Methods and Reproducibility of Grading Optimized Digital Color Fundus Photographs in the Age-Related Eye Disease Study 2 (AREDS2 Report Number 2) Free

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Ronald P. Danis; Amitha Domalpally; Emily Y. Chew; Traci E. Clemons; Jane Armstrong; John Paul SanGiovanni; Frederick L. Ferris, III

Tags: color, eye diseases, fundus photography, eye, drusen

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4548-4554. doi:https://doi.org/10.1167/iovs.13-11804

Region-Specific Relationships Between Refractive Error and Ciliary Muscle Thickness in Children Free

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Andrew D. Pucker; Loraine T. Sinnott; Chiu-Yen Kao; Melissa D. Bailey

Tags: child, ciliary muscle, hyperopia, refractive errors

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4710-4716. doi:https://doi.org/10.1167/iovs.13-11658

A Prospective Study of Spherical Refractive Error and Ocular Components Among Northern Irish Schoolchildren (The NICER Study) Free

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Karen M. M. Breslin; Lisa O'Donoghue; Kathryn J. Saunders

Tags: cohort studies, prospective studies, refractive errors, school-age child

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4843-4850. doi:https://doi.org/10.1167/iovs.13-11813

Autologous Transplantation of Simple Retinal Pigment Epithelium Sheet for Massive Submacular Hemorrhage Associated With Pigment Epithelium Detachment Free

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Liang Han; Zhizhong Ma; Changguan Wang; Hongliang Dou; Yuntao Hu; Xuefeng Feng; Yimin Xu; Zhengqin Yin; Xin Wang

Tags: epithelium, hemorrhage, pigment, surgical procedures, operative, transplantation

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4956-4963. doi:https://doi.org/10.1167/iovs.13-11957

Associations With Retinal Nerve Fiber Layer Measures in the EPIC-Norfolk Eye Study Free

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Anthony P. Khawaja; Michelle P. Y. Chan; David F. Garway-Heath; David C. Broadway; Robert Luben; Justin C. Sherwin; Shabina Hayat; Kay-Tee Khaw; Paul J. Foster

Tags: eye, retinal nerve fiber layer, glaucoma, body mass index procedure

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 5028-5034. doi:https://doi.org/10.1167/iovs.13-11971

Cornea

Chemical Injury-Induced Corneal Opacity and Neovascularization Reduced by Rapamycin via TGF-β1/ERK Pathways Regulation Free

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Young Joo Shin; Joon Young Hyon; Won Seok Choi; Kayoung Yi; Eui-Sang Chung; Tae-Young Chung; Won Ryang Wee

Tags: cornea, corneal opacity, neovascularization, pathologic, rapamycin, wounds and injuries

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4452-4458. doi:https://doi.org/10.1167/iovs.13-11684

Effect of Panretinal Photocoagulation on Corneal Sensation and the Corneal Subbasal Nerve Plexus in Diabetes Mellitus Free

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Stuti Misra; Ha Na Ahn; Jennifer P. Craig; Monika Pradhan; Dipika V. Patel; Charles N. J. McGhee

Tags: cornea, diabetes mellitus, neurons, panretinal photocoagulation, sensory perception

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4485-4490. doi:https://doi.org/10.1167/iovs.12-10571

Identification of Cell Surface Markers Glypican-4 and CD200 That Differentiate Human Corneal Endothelium From Stromal Fibroblasts Free

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Yuen Kuen Cheong; Zi Xian Ngoh; Gary Swee Lim Peh; Heng-Pei Ang; Xin-Yi Seah; Zhenzhi Chng; Alan Colman; Jodhbir S. Mehta; William Sun

Tags: antibodies, cornea, corneal endothelium, fibroblasts, rna

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4538-4547. doi:https://doi.org/10.1167/iovs.13-11754

Serum Deprivation Can Suppress Receptor-Mediated Calcium Signaling in Pterygial-Derived Fibroblasts Free

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Chunlai Fang; Christopher D. Illingworth; Limin Qian; I. Michael Wormstone

Tags: calcium signaling, fibroblasts, thapsigargin, cell growth, calcium

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4563-4570. doi:https://doi.org/10.1167/iovs.13-11604

Elevation of Conjunctival Epithelial CD45^INTCD11b⁺CD16⁺CD14⁻ Neutrophils in
Ocular Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis Free

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Geraint P. Williams; Paul J. Tomlins; Alastair K. Denniston; H. Susan Southworth; Sreekanth Sreekantham; S. John Curnow; Saaeha Rauz

Tags: antigens, cd16, cd14 antigen, cd45 antigens, conjunctiva, epidermal necrolysis, toxic

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4578-4585. doi:https://doi.org/10.1167/iovs.13-11859

Mitochondrial Permeability Transition Pore in Inflammatory Apoptosis of Human Conjunctival Epithelial Cells and T Cells: Effect of Cyclosporin A Free

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Jianping Gao; Reuben Sana; Virginia Calder; Margarita Calonge; Wanju Lee; Larry A. Wheeler; Michael E. Stern

Tags: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, apoptosis, cyclosporine, mitochondria, t-lymphocytes

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4717-4733. doi:https://doi.org/10.1167/iovs.13-11681

The Aging Meibomian Gland: An In Vivo Confocal Study Free

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Edoardo Villani; Veronica Canton; Fabrizio Magnani; Francesco Viola; Paolo Nucci; Roberto Ratiglia

Tags: aging, meibomian gland, bodily secretions, atrophic condition of skin, diameter

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4735-4740. doi:https://doi.org/10.1167/iovs.13-11914

Diesel Exhaust Particles Selectively Induce Both Proinflammatory Cytokines and Mucin Production in Cornea and Conjunctiva Human Cell Lines Free

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Julia Tau; Priscila Novaes; Monique Matsuda; Deborah R. Tasat; Paulo H. Saldiva; Alejandro Berra

Tags: cell lines, conjunctiva, cornea, cytokine, diesel exhaust

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4759-4766. doi:https://doi.org/10.1167/iovs.12-10541

The Progression of Haze Formation in Rabbit Corneas Following Phototherapeutic Keratectomy Free

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Daniel J. Gibson; Sonal S. Tuli; Gregory S. Schultz

Tags: cornea, corneal opacity, oryctolagus cuniculus, wounds and injuries

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4776-4781. doi:https://doi.org/10.1167/iovs.13-11976

The Ocular Redness Index: A Novel Automated Method for Measuring Ocular Injection Free

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Francisco Amparo; Haobing Wang; Parisa Emami-Naeini; Parisa Karimian; Reza Dana

Tags: balance, device, clinicians, computers, conjunctiva, equilibrium

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4821-4826. doi:https://doi.org/10.1167/iovs.13-12217

Tear Film Breakup and Structure Studied by Simultaneous Video Recording of Fluorescence and Tear Film Lipid Layer Images Free

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P. Ewen King-Smith; Kathleen S. Reuter; Richard J. Braun; Jason J. Nichols; Kelly K. Nichols

Tags: fluorescence, lipids, tear film finding, video recording, fluorescein

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4900-4909. doi:https://doi.org/10.1167/iovs.13-11878

Effect of Instillation of Eyedrops for Dry Eye on Optical Quality Free

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Shizuka Koh; Naoyuki Maeda; Chikako Ikeda; Yoshihiro Takai; Hisataka Fujimoto; Yoshinori Oie; Takeshi Soma; Motokazu Tsujikawa; Kohji Nishida

Tags: dry eye syndromes, eyedrops, optics

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4927-4933. doi:https://doi.org/10.1167/iovs.13-12409

Corneal Resistance to Shear Force After UVA-Riboflavin Cross-Linking Free

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Anders P. Søndergaard; Anders Ivarsen; Jesper Hjortdal

Tags: cornea, corneal collagen cross-linking, riboflavin, suidae, ultraviolet a radiation

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 5059-5069. doi:https://doi.org/10.1167/iovs.12-10710

Contributing Factors to Corneal Deformation in Air Puff Measurements Free

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Sabine Kling; Susana Marcos

Tags: cornea, eye, intraocular pressure

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 5078-5085. doi:https://doi.org/10.1167/iovs.13-12509

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Noninvasive Assessments of Optic Nerve Neurodegeneration in Transgenic Mice With Isolated Optic Neuritis Free

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Venu Talla; Cui Yang; Gerry Shaw; Vittorio Porciatti; Rajeshwari D. Koilkonda; John Guy

Tags: animals, transgenic, mice, mice, transgenic, nerve degeneration, optic nerve

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4440-4450. doi:https://doi.org/10.1167/iovs.13-11899

The Pupil Light Reflex in Leber's Hereditary Optic Neuropathy: Evidence for Preservation of Melanopsin-Expressing Retinal Ganglion Cells Free

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Ana Laura A. Moura; Balázs V. Nagy; Chiara La Morgia; Piero Barboni; André Gustavo Fernandes Oliveira; Solange R. Salomão; Adriana Berezovsky; Milton Nunes de Moraes-Filho; Carlos Filipe Chicani; Rubens Belfort, Jr; Valerio Carelli; Alfredo A. Sadun; Donald C. Hood; Dora Fix Ventura

Tags: melanopsin, optic atrophy, hereditary, leber, pupil light reflex, retinal ganglion cells

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4471-4477. doi:https://doi.org/10.1167/iovs.12-11137

SIRT1 Promotes RGC Survival and Delays Loss of Function Following Optic Nerve Crush Free

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Ling Zuo; Reas S. Khan; Vivian Lee; Kimberly Dine; Wen Wu; Kenneth S. Shindler

Tags: mice, neuroprotection, optic nerve, resveratrol, protein overexpression

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 5097-5102. doi:https://doi.org/10.1167/iovs.13-12157

Genetics

Survey of Common Eye Diseases in Laboratory Mouse Strains Free

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Bo Chang; Ron Hurd; Jieping Wang; Patsy Nishina

Tags: eye diseases, genotype determination, mice, mutation, surveys

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4974-4981. doi:https://doi.org/10.1167/iovs.13-12289

Replication and Meta-Analysis of Candidate Loci Identified Variation at RAB3GAP1 Associated With Keratoconus Free

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Ha Ae Bae; Richard A. D. Mills; Richard G. Lindsay; Tony Phillips; Douglas J. Coster; Paul Mitchell; Jie Jin Wang; Jamie E. Craig; Kathryn P. Burdon

Tags: keratoconus, meta-analysis, single nucleotide polymorphism, cohort studies

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 5132-5135. doi:https://doi.org/10.1167/iovs.13-12377

Glaucoma

Macular Ganglion Cell Imaging Study: Glaucoma Diagnostic Accuracy of Spectral-Domain Optical Coherence Tomography Free

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Jin Wook Jeoung; Yun Jeong Choi; Ki Ho Park; Dong Myung Kim

Tags: diagnostic imaging, ganglia, glaucoma, retinal nerve fiber layer, optical coherence tomography

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4422-4429. doi:https://doi.org/10.1167/iovs.12-11273

Comparative Assessment for the Ability of Cirrus, RTVue, and 3D-OCT to Diagnose Glaucoma Free

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Azusa Akashi; Akiyasu Kanamori; Makoto Nakamura; Masashi Fujihara; Yuko Yamada; Akira Negi

Tags: glaucoma, eye

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4478-4484. doi:https://doi.org/10.1167/iovs.12-11268

Circle- and Grid-Wise Analyses of Peripapillary Nerve Fiber Layers by Spectral Domain Optical Coherence Tomography in Early-Stage Glaucoma Free

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Chihiro Mayama; Hitomi Saito; Hiroyo Hirasawa; Shinsuke Konno; Atsuo Tomidokoro; Makoto Araie; Aiko Iwase; Shinji Ohkubo; Kazuhisa Sugiyama; Tomohiro Otani; Shoji Kishi; Kenji Matsushita; Naoyuki Maeda; Masanori Hangai; Nagahisa Yoshimura

Tags: glaucoma, optical coherence tomography, sensitivity and specificity, nerve fibers, specificity of diagnostic test

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4519-4526. doi:https://doi.org/10.1167/iovs.13-11603

Ocular Rigidity, Outflow Facility, Ocular Pulse Amplitude, and Pulsatile Ocular Blood Flow in Open-Angle Glaucoma: A Manometric Study Free

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Anna I. Dastiridou; Evangelia E. Tsironi; Miltiadis K. Tsilimbaris; Harilaos Ginis; Nikos Karyotakis; Pierros Cholevas; Sofia Androudi; Ioannis G. Pallikaris

Tags: glaucoma, intraocular pressure, manometry, muscle rigidity, open-angle glaucoma

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4571-4577. doi:https://doi.org/10.1167/iovs.13-12303

The Prevalence and Types of Glaucoma in an Urban Indian Population: The Singapore Indian Eye Study Free

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Arun Narayanaswamy; Mani Baskaran; Yingfeng Zheng; Raghavan Lavanya; Renyi Wu; Wan-Ling Wong; Seang-Mei Saw; Ching-Yu Cheng; Tien-Yin Wong; Tin Aung

Tags: eye, glaucoma, prevalence, singapore, open-angle glaucoma

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4621-4627. doi:https://doi.org/10.1167/iovs.13-11950

Iridotrabecular Contact Observed Using Anterior Segment Three-Dimensional OCT in Eyes With a Shallow Peripheral Anterior Chamber Free

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Koichi Mishima; Atsuo Tomidokoro; Pitipong Suramethakul; Naomi Mataki; Naoyuki Kurita; Chihiro Mayama; Makoto Araie

Tags: anterior chamber of eye, eye, isolated tumor cells, ultrasound biomicroscopy

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4628-4635. doi:https://doi.org/10.1167/iovs.12-11230

Enhanced Pressure in the Central Retinal Vein Decreases the Perfusion Pressure in the Prelaminar Region of the Optic Nerve Head Free

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Richard Stodtmeister; Sylvana Ventzke; Eberhard Spoerl; Andreas G. Boehm; Naim Terai; Michael Haustein; Lutz E. Pillunat

Tags: central retinal vein, eye, intraocular pressure, optic disk, perfusion

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4698-4704. doi:https://doi.org/10.1167/iovs.12-10607

Transforming Growth Factor-β2 Induces Expression of Biologically Active Bone Morphogenetic Protein-1 in Human Trabecular Meshwork Cells Free

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Tara Tovar-Vidales; Ashley M. Fitzgerald; Abbot F. Clark; Robert J. Wordinger

Tags: proteins, trabecular meshwork, enzyme activity, body tissue

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4741-4748. doi:https://doi.org/10.1167/iovs.13-12203

Hydroxycamptothecin Induces Apoptosis of Human Tenon's Capsule Fibroblasts by Activating the PERK Signaling Pathway Free

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Xue Yin; Hong Sun; Dongyi Yu; Ya Liang; Zhilan Yuan; Yingbin Ge

Tags: apoptosis, fibroblasts, mitochondria, tenon's capsule, signal pathway

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4749-4758. doi:https://doi.org/10.1167/iovs.12-11447

Three-Dimensional Imaging of Lamina Cribrosa Defects in Glaucoma Using Swept-Source Optical Coherence Tomography Free

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Kohei Takayama; Masanori Hangai; Yugo Kimura; Satoshi Morooka; Masayuki Nukada; Tadamichi Akagi; Hanako Ohashi Ikeda; Akiko Matsumoto; Nagahisa Yoshimura

Tags: cribriform plate, diagnostic imaging, eye, glaucoma, optical coherence tomography

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4798-4807. doi:https://doi.org/10.1167/iovs.13-11677

Sources of Structural Autofluorescence in the Human Trabecular Meshwork Free

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Alex S. Huang; Jose M. Gonzalez, Jr.; Phuc V. Le; Martin Heur; James C. H. Tan

Tags: autofluorescence, body tissue, eosine yellowish-(ys), trabecular meshwork, fluorescence

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4813-4820. doi:https://doi.org/10.1167/iovs.12-11235

Oxidative Stress Impact on Barrier Function of Porcine Angular Aqueous Plexus Cell Monolayers Free

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Yuan Lei; William D. Stamer; Jihong Wu; Xinghuai Sun

Tags: oxidative stress, suidae, hyperoxia, aging, galactosidase

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4827-4835. doi:https://doi.org/10.1167/iovs.12-11435

Posterior Displacement of the Lamina Cribrosa in Glaucoma: In Vivo Interindividual and Intereye Comparisons Free

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Rafael L. Furlanetto; Sung Chul Park; Uma J. Damle; Sandra Fernando Sieminski; Yungtai Kung; Nora Siegal; Jeffrey M. Liebmann; Robert Ritch

Tags: cribriform plate, eye, glaucoma

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4836-4842. doi:https://doi.org/10.1167/iovs.12-11530

Pro-Inflammatory Cytokines in Glaucomatous Aqueous and Encysted Molteno Implant Blebs and Their Relationship to Pressure Free

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Jeffrey Freedman; Pavel Iserovich

Tags: blister, cytokine, glaucoma, molteno implants

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4851-4855. doi:https://doi.org/10.1167/iovs.13-12274

ATP-Sensitive Potassium (K_ATP) Channel Openers Diazoxide and Nicorandil Lower Intraocular Pressure In Vivo Free

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Uttio Roy Chowdhury; Bradley H. Holman; Michael P. Fautsch

Tags: diazoxide, eye, intraocular pressure, mice, nicorandil

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4892-4899. doi:https://doi.org/10.1167/iovs.13-11872

Otago Glaucoma Surgery Outcome Study: Cytology and Immunohistochemistry of Trabeculectomy Blebs Free

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Anthony C. B. Molteno; Tui H. Bevin; Alex G. Dempster; Maria Sarris; Peter McCluskey

Tags: blister, immunohistochemistry, trabeculectomy

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4991-5000. doi:https://doi.org/10.1167/iovs.12-11553

Activated αvβ3 Integrin Regulates αvβ5 Integrin–Mediated Phagocytosis in Trabecular Meshwork Cells Free

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Debjani Gagen; Mark S. Filla; Ross Clark; Paloma Liton; Donna M. Peters

Tags: integrins, phagocytosis

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 5000-5011. doi:https://doi.org/10.1167/iovs.13-12084

Immunology and Microbiology

Staphylococcus aureus Corneal Infections: Effect of the Panton-Valentine Leukocidin (PVL) and Antibody to PVL on Virulence and Pathology Free

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Tanweer Zaidi; Tauqeer Zaidi; Pauline Yoong; Gerald B. Pier

Tags: antibodies, cornea, corneal infections, keratitis, mice

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4430-4438. doi:https://doi.org/10.1167/iovs.13-11701

Development of Standardized Methods for Assessing Biocidal Efficacy of Contact Lens Care Solutions Against Acanthamoeba Trophozoites and Cysts Free

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Simon Kilvington; Anthony Lam

Tags: acanthamoeba, cysts, trophozoite, contact lens care

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4527-4537. doi:https://doi.org/10.1167/iovs.13-11927

Lens

Extralenticular and Lenticular Aspects of Accommodation and Presbyopia in Human Versus Monkey Eyes Free

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Mary Ann Croft; Jared P. McDonald; Alexander Katz; Ting-Li Lin; Elke Lütjen-Drecoll; Paul L. Kaufman

Tags: cercopithecidae, ciliary muscle, eye, lens (device), lens, crystalline

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 5035-5048. doi:https://doi.org/10.1167/iovs.12-10846

Accommodative Movements of the Vitreous Membrane, Choroid, and Sclera in Young and Presbyopic Human and Nonhuman Primate Eyes Free

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Mary Ann Croft; T. Michael Nork; Jared P. McDonald; Alexander Katz; Elke Lütjen-Drecoll; Paul L. Kaufman

Tags: choroid, eye, sclera, tissue membrane, visual accommodation

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 5049-5058. doi:https://doi.org/10.1167/iovs.12-10847

In Vivo Analysis of Aquaporin 0 Function in Zebrafish: Permeability Regulation Is Required for Lens Transparency Free

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Daniel M. Clemens; Karin L. Németh-Cahalan; Lien Trinh; Tailin Zhang; Thomas F. Schilling; James E. Hall

Tags: cataract, lens (device), lens, crystalline, permeability, regulation

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 5136-5143. doi:https://doi.org/10.1167/iovs.13-12337

Low Vision

Vision and Quality of Life Index: Validation of the Indian Version Using Rasch Analysis Free

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Vijaya K. Gothwal; Deepak K. Bagga

Tags: quality of life, rasch model, vision, psychometrics, visual impairment

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4871-4881. doi:https://doi.org/10.1167/iovs.13-11892

Multidisciplinary Ophthalmic Imaging

Bulbar Conjunctival Thickness Measurements With Optical Coherence Tomography in Healthy Chinese Subjects Free

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Xingru Zhang; Qingsong Li; Minhong Xiang; Haidong Zou; Bin Liu; Huanming Zhou; Zhumei Han; Zhixuan Fu; Zhenyong Zhang; Hanmin Wang

Tags: chinese (other dialects), chinese people, conjunctiva, optical coherence tomography

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4705-4709. doi:https://doi.org/10.1167/iovs.12-11003

Distribution and Determinants of Eye Size and Shape in Newborn Children: A Magnetic Resonance Imaging Analysis Free

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Laurence Shen Lim; Gim Hong Chong; Pei Ting Tan; Yap-Seng Chong; Kenneth Kwek; Peter D. Gluckman; Marielle V. Fortier; Seang-Mei Saw; Anqi Qiu

Tags: child, eye, magnetic resonance imaging, newborn

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4791-4797. doi:https://doi.org/10.1167/iovs.12-10713

Nantotechnology and Regenerative Medicine

Topical Silver Nanoparticles Result in Improved Bleb Function by Increasing Filtration and Reducing Fibrosis in a Rabbit Model of Filtration Surgery Free

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Michelle R. Butler; Claudia M. Prospero Ponce; Y. Etan Weinstock; Silvia Orengo-Nania; Patricia Chevez-Barrios; Benjamin J. Frankfort

Tags: blister, eye, fibrosis, filtering surgery, filtration

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4982-4990. doi:https://doi.org/10.1167/iovs.13-12047

Physiology and Pharmacology

Differential Effects of Prostaglandin E₂-Sensitive Receptors on Contractility of Human Ocular Cells That Regulate Conventional Outflow Free

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Jenny W. Wang; David F. Woodward; W. Daniel Stamer

Tags: agonists, electric impedance, prostaglandins e, antagonists, thrombin

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4782-4790. doi:https://doi.org/10.1167/iovs.13-12363

Enzyme-Induced Vitreolysis Can Alleviate the Progression of Diabetic Retinopathy Through the HIF-1α Pathway Free

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Chuanyin Li; Ping Chen; Jingfa Zhang; Limei Zhang; Xiaolin Huang; Yuting Yao; Xin Che; Xianqun Fan; Shengfang Ge; Zhiliang Wang

Tags: diabetes mellitus, diabetic retinopathy, enzymes, fibroblast growth factor 2, oxygen

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4964-4970. doi:https://doi.org/10.1167/iovs.12-11443

Effect of Nitric Oxide on Anterior Segment Physiology in Monkeys Free

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Galen W. Heyne; Julie A. Kiland; Paul L. Kaufman; B'Ann T. Gabelt

Tags: cercopithecidae, eye, intraocular pressure, nitric oxide, single nucleotide polymorphism

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 5103-5110. doi:https://doi.org/10.1167/iovs.12-11491

Postocclusive Reactive Hyperemia Occurs in the Rat Retinal Circulation but Not in the Choroid Free

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Guang Li; Jeffrey W. Kiel; Damon P. Cardenas; Bryan H. De La Garza; Timothy Q. Duong

Tags: choroid, reactive hyperemia, retina circulation

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 5123-5131. doi:https://doi.org/10.1167/iovs.13-12404

Retina

Staging of Macular Telangiectasia: Power-Doppler Optical Coherence Tomography and Macular Pigment Optical Density Free

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Eric K. Chin; Dae Yu Kim; Allan A. Hunter, III; Suman Pilli; Machelle Wilson; Robert J. Zawadzki; John S. Werner; Susanna S. Park

Tags: eye, optical coherence tomography, optics, pigment, telangiectasis

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4459-4470. doi:https://doi.org/10.1167/iovs.12-11116

Progressive Changes of Regional Macular Thickness After Macular Hole Surgery With Internal Limiting Membrane Peeling Free

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Kazuyuki Kumagai; Masanori Hangai; Eric Larson; Nobuchika Ogino

Tags: postoperative care, repair of hole of macula lutea, surgical procedures, operative, tissue membrane, surgery specialty

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4491-4497. doi:https://doi.org/10.1167/iovs.13-11662

Ablation of the X-Linked Retinitis Pigmentosa 2 (Rp2) Gene in Mice Results in Opsin Mislocalization and Photoreceptor Degeneration Free

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Linjing Li; Naheed Khan; Toby Hurd; Amiya Kumar Ghosh; Christiana Cheng; Robert Molday; John R. Heckenlively; Anand Swaroop; Hemant Khanna

Tags: ablation, genes, mice, opsin, photoreceptors

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4503-4511. doi:https://doi.org/10.1167/iovs.13-12140

Effect of Optical Coherence Tomography Scan Decentration on Macular Center Subfield Thickness Measurements Free

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Jeong W. Pak; Ashwini Narkar; Sapna Gangaputra; Ronald Klein; Barbara Klein; Stacy Meuer; Yijun Huang; Ronald P. Danis

Tags: optical coherence tomography, significance, fovea centralis, eye

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4512-4518. doi:https://doi.org/10.1167/iovs.13-12265

Adiponectin-Induced Dilation of Isolated Porcine Retinal Arterioles via Production of Nitric Oxide From Endothelial Cells Free

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Tsuneaki Omae; Taiji Nagaoka; Ichiro Tanano; Akitoshi Yoshida

Tags: adiponectin, arteriole, dilatation, pathologic, nitric oxide, vasodilation

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4586-4594. doi:https://doi.org/10.1167/iovs.13-11756

Three Different Phenotypes of Mild Nonproliferative Diabetic Retinopathy With Different Risks for Development of Clinically Significant Macular Edema Free

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Sandrina Nunes; Luisa Ribeiro; Conceição Lobo; José Cunha-Vaz

Tags: edema, nonproliferative diabetic retinopathy, phenotype, eye

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4595-4604. doi:https://doi.org/10.1167/iovs.13-11895

Optical Coherence Tomography–Assisted Enhanced Depth Imaging of Central Serous Chorioretinopathy Free

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Lihong Yang; Jost B. Jonas; Wenbin Wei

Tags: central serous chorioretinopathy, diagnostic imaging, eye, optical coherence tomography, bruch's basal membrane

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4659-4665. doi:https://doi.org/10.1167/iovs.12-10991

Clinical Characteristics of Rod and Cone Photoreceptor Dystrophies in Patients With Mutations in the C8orf37 Gene Free

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Ramon A. C. van Huet; Alejandro Estrada-Cuzcano; Eyal Banin; Ygal Rotenstreich; Stephanie Hipp; Susanne Kohl; Carel B. Hoyng; Anneke I. den Hollander; Rob W. J. Collin; B. Jeroen Klevering

Tags: genes, mutation, retinal cone, rod photoreceptors, polydactyly

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4683-4690. doi:https://doi.org/10.1167/iovs.12-11439

Adjustment of the Retinal Angle in SD-OCT of Glaucomatous Eyes Provides Better Intervisit Reproducibility of Peripapillary RNFL Thickness Free

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Kyungmoo Lee; Milan Sonka; Young H. Kwon; Mona K. Garvin; Michael D. Abràmoff

Tags: eye, glaucoma, retinal nerve fiber layer, optic disk

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4808-4812. doi:https://doi.org/10.1167/iovs.13-12211

Clinical and Genetic Characteristics of Korean Occult Macular Dystrophy Patients Free

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Seong Joon Ahn; Sung Im Cho; Jeeyun Ahn; Sung Sup Park; Kyu Hyung Park; Se Joon Woo

Tags: diagnostic imaging, genetics, genotype, korean, macular dystrophy

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4856-4863. doi:https://doi.org/10.1167/iovs.13-11643

The Long-Term Course of Functional and Anatomical Recovery After Macular Hole Surgery Free

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Konstantine Purtskhvanidze; Felix Treumer; Olaf Junge; Jürgen Hedderich; Johann Roider; Jost Hillenkamp

Tags: eye, follow-up, postoperative care, recovery of function, repair of hole of macula lutea

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4882-4891. doi:https://doi.org/10.1167/iovs.13-11699

Intravitreal Tenecteplase (Metalyse) for Acute Management of Retinal Vein Occlusions Free

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Ian L. McAllister; Sarojini Vijayasekaran; Dao-Yi Yu

Tags: central retinal vein, did not receive therapy or drug, eye, intravitreal injections, retinal vein occlusion

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4910-4918. doi:https://doi.org/10.1167/iovs.13-11967

Effect of Age on Individual Retinal Layer Thickness in Normal Eyes as Measured With Spectral-Domain Optical Coherence Tomography Free

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Nazli Demirkaya; Hille W. van Dijk; Sanne M. van Schuppen; Michael D. Abràmoff; Mona K. Garvin; Milan Sonka; Reinier O. Schlingemann; Frank D. Verbraak

Tags: eye, optical coherence tomography, retinal nerve fiber layer

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4934-4940. doi:https://doi.org/10.1167/iovs.13-11913

Inner Retinal Oxygen Delivery and Metabolism Under Normoxia and Hypoxia in Rat Free

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Justin Wanek; Pang-yu Teng; Norman P. Blair; Mahnaz Shahidi

Tags: hypoxia, metabolism, oxygen delivery, oxygen, diagnostic imaging

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 5012-5019. doi:https://doi.org/10.1167/iovs.13-11887

Subretinal Implantation of Retinal Pigment Epithelial Cells Derived From Human Embryonic Stem Cells: Improved Survival When Implanted as a Monolayer Free

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Bruno Diniz; Padmaja Thomas; Biju Thomas; Ramiro Ribeiro; Yuntao Hu; Rodrigo Brant; Ashish Ahuja; Danhong Zhu; Laura Liu; Michael Koss; Mauricio Maia; Gerald Chader; David R. Hinton; Mark S. Humayun

Tags: embryonic stem cells, eye, implantation procedure, retinal pigment cell, surgical procedures, operative

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 5087-5096. doi:https://doi.org/10.1167/iovs.12-11239

Retinal Cell Biology

Disruption of Cell-Cell Junctions and Induction of Pathological Cytokines in the Retinal Pigment Epithelium of Light-Exposed Mice Free

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Toshio Narimatsu; Yoko Ozawa; Seiji Miyake; Shunsuke Kubota; Manabu Hirasawa; Norihiro Nagai; Shigeto Shimmura; Kazuo Tsubota

Tags: actins, cytokine, light exposure, mice, oxidative stress

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4555-4562. doi:https://doi.org/10.1167/iovs.12-11572

Impairment of Intrinsically Photosensitive Retinal Ganglion Cells Associated With Late Stages of Retinal Degeneration Free

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Gema Esquiva; Pedro Lax; Nicolás Cuenca

Tags: dendrites, impairment, melanopsin, rats, retina

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4605-4618. doi:https://doi.org/10.1167/iovs.13-12120

Apoptotic and Proliferative Defects Characterize Ocular Development in a Microphthalmic BMP Model Free

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Curtis R. French; Tara R. Stach; Lindsey D. March; Ordan J. Lehmann; Andrew J. Waskiewicz

Tags: embryo, eye, eye development, genes, microphthalmos

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4636-4647. doi:https://doi.org/10.1167/iovs.13-11674

The Photopic Negative Response of the Mouse Electroretinogram: Reduction by Acute Elevation of Intraocular Pressure Free

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Vicki Chrysostomou; Jonathan G. Crowston

Tags: electroretinography, eye, intraocular pressure, mice, retina

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4691-4697. doi:https://doi.org/10.1167/iovs.13-12415

Prolyl Hydroxylase Inhibition During Hyperoxia Prevents Oxygen-Induced Retinopathy in the Rat 50/10 Model Free

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George Trichonas; Tamara J. Lee; George Hoppe; John Au; Jonathan E. Sears

Tags: hyperoxia, oxygen, procollagen-proline dioxygenase, retinal diseases

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4919-4926. doi:https://doi.org/10.1167/iovs.13-12171

Translational

Doxycycline Prevents Matrix Remodeling and Contraction by Trichiasis-Derived Conjunctival Fibroblasts Free

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He Li; Daniel G. Ezra; Matthew J. Burton; Maryse Bailly

Tags: conjunctiva, doxycycline, eyelid trichiasis, fibroblasts, collagen

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4675-4682. doi:https://doi.org/10.1167/iovs.13-11787

Visual Neuroscience

Photoreceptor and Postreceptor Responses in Congenital Stationary Night Blindness Free

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Aparna Raghuram; Ronald M. Hansen; Anne Moskowitz; Anne B. Fulton

Tags: electroretinography, night blindness, congenital stationary, photoreceptors, rod photoreceptors

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4648-4658. doi:https://doi.org/10.1167/iovs.13-12111

Visual Psychophysics and Physiological Optics

Improving Detection of Mild Loss of Retinal Light Increment Sensitivity at the Posterior Pole With the Microperimeter MP1 Free

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Wadim Bowl; Birgit Lorenz; Melanie Jäger; Christoph Friedburg

Tags: attenuation, box plot, color, eye, fovea centralis

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4666-4674. doi:https://doi.org/10.1167/iovs.12-11241

Is Adaptation to Perceived Interocular Differences in Height Explained by Vertical Fusional Eye Movements? Free

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Felix M. Maier; Frank Schaeffel

Tags: eye, eye movement, perception, prisms, psychophysics

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 5020-5026. doi:https://doi.org/10.1167/iovs.13-11857

Clinical Trials

Vision-Related Functioning Outcomes of Dexamethasone Intravitreal Implant in Noninfectious Intermediate or Posterior Uveitis Free

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Susan Lightman; Rubens Belfort, Jr.; Rupali K. Naik; Careen Lowder; C. Stephen Foster; Anne M. Rentz; Harry Cui; Scott M. Whitcup; Jonathan W. Kowalski; Dennis A. Revicki

Tags: dexamethasone, implants, uveitis, posterior, vision, intravitreal implants

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4864-4870. doi:https://doi.org/10.1167/iovs.12-10981

Review

Why Do Only Some Hyperopes Become Strabismic? Free

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Erin Babinsky; T. Rowan Candy

Tags: adult, child, esotropia, hyperopia, infant

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4941-4955. doi:https://doi.org/10.1167/iovs.12-10670

Letters to the Editor

The Role of Ocular Perfusion Pressure in Glaucoma Cannot Be Studied With Multivariable Regression Analysis Applied to Surrogates Free

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Anthony P. Khawaja; David P. Crabb; Nomdo M. Jansonius

Tags: glaucoma, multivariate analysis, perfusion, intraocular pressure

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4619-4620. doi:https://doi.org/10.1167/iovs.13-12487

Human Corneal Endothelium Regeneration: Effect of ROCK Inhibitor Free

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Virgilio Galvis; Alejandro Tello; Álvaro J. Gutierrez

Tags: corneal endothelium, endothelial cells, cornea

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4971-4973. doi:https://doi.org/10.1167/iovs.13-12388

RNFL Damage After Treatment for Retinal Detachment Free

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Menelaos Kanakis; Ilias Georgalas; Chryssanthi Koutsandrea

Tags: retinal detachment, retinal nerve fiber layer

Investigative Ophthalmology & Visual Science July 2013, Vol.54, 5027. doi:https://doi.org/10.1167/iovs.13-12426

Erratum

Erratum Free

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Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4451. doi:https://doi.org/10.1167/iovs.12-10341a

Erratum Free

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Investigative Ophthalmology & Visual Science July 2013, Vol.54, 4734. doi:https://doi.org/10.1167/iovs.11-9419a

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