Select a back issue
Select a back issue
  • Alerts
    User Alerts
    You are adding an alert for:
    Investigative Ophthalmology & Visual Science
    You will receive an email whenever new content is published in the Investigative Ophthalmology & Visual Science. You can manage this and all other alerts in My Account
    The alert will be sent to:
    ×
    This feature is available to authenticated users only.
    Sign In or Create an Account ×

Research Highlight

A Significant Advance in the Biomechanical Evaluation of the Optic Nerve Head Free
PDF
Thao D. Nguyen
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 215. doi:10.1167/iovs.13-13789
Toward an Improved Understanding of the Physiology of Aqueous Humor Flow Free
PDF
J. Cameron Millar
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 404. doi:10.1167/iovs.13-13753

Anatomy and Pathology/Oncology

Enzymatic Degradation Identifies Components Responsible for the Structural Properties of the Vitreous Body Free
PDF
Benjamen A. Filas; Qianru Zhang; Ruth J. Okamoto; Ying-Bo Shui; David C. Beebe
Tags: vitreous body, catabolism
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 55-63. doi:10.1167/iovs.13-13026
Ocular Changes in TgF344-AD Rat Model of Alzheimer's Disease Free
PDF
Yuchun Tsai; Bin Lu; Alexander V. Ljubimov; Sergey Girman; Fred N. Ross-Cisneros; Alfredo A. Sadun; Clive N. Svendsen; Robert M. Cohen; Shaomei Wang
Tags: alzheimer's disease, antibodies, choroid, eye, rats
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 523-534. doi:10.1167/iovs.13-12888

Biochemistry and Molecular Biology

Biophysical and Morphological Evaluation of Human Normal and Dry Eye Meibum Using Hot Stage Polarized Light Microscopy Free
PDF
Igor A. Butovich; Hua Lu; Anne McMahon; Howard Ketelson; Michelle Senchyna; David Meadows; Elaine Campbell; Mike Molai; Emily Linsenbardt
Tags: birefringence, dry eye syndromes, lipids, proteins, temperature
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 87-101. doi:10.1167/iovs.13-13355
Effect of Nerve Growth Factor on the In Vitro Induction of Apoptosis of Human Conjunctival Epithelial Cells by Hyperosmolar Stress Free
PDF
Soon-Suk Kang; Sae-Jin Ha; Eun-Soon Kim; Jin-A Shin; Jae Yong Kim; Hungwon Tchah
Tags: apoptosis, conjunctival epithelial cells, hyperosmolality, hyperosmolar hyperglycemia, nerve growth factors
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 535-541. doi:10.1167/iovs.13-12459

Clinical and Epidemiologic Research

Corneal Biomechanical Properties and Glaucoma-Related Quantitative Traits in the EPIC-Norfolk Eye Study Free
PDF
Anthony P. Khawaja; Michelle P. Y. Chan; David C. Broadway; David F. Garway-Heath; Robert Luben; Jennifer L. Y. Yip; Shabina Hayat; Kay-Tee Khaw; Paul J. Foster
Tags: cornea, corneal hysteresis, eye, glaucoma, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 117-124. doi:10.1167/iovs.13-13290
Accuracy of Rural Refractionists in Western China Free
PDF
Zhongqiang Zhou; Junxia Zeng; Xiaochen Ma; Xiaopeng Pang; Hongmei Yi; Qianyun Chen; Mirjam E. Meltzer; Mingguang He; Scott Rozelle; Nathan Congdon
Tags: child, china, eye, refraction, refractive errors
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 154-161. doi:10.1167/iovs.13-13250
Reduced Fluorescein Angiography and Fundus Photography Use in the Management of Neovascular Macular Degeneration and Macular Edema During the Past Decade Free
PDF
Eric W. Schneider; Prithvi Mruthyunjaya; Nidhi Talwar; Kristen Harris Nwanyanwu; Bin Nan; Joshua D. Stein
Tags: diagnostic imaging, diagnostic techniques and procedures, edema, fluorescein angiography, fundus photography
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 542-549. doi:10.1167/iovs.13-13034
Subfoveal Choroidal Thickness in 1323 Children Aged 11 to 12 Years and Association With Puberty: The Copenhagen Child Cohort 2000 Eye Study Free
PDF
Xiao Qiang Li; Pia Jeppesen; Michael Larsen; Inger Christine Munch
Tags: child, cohort studies, eye, puberty, body weight
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 550-555. doi:10.1167/iovs.13-13476
Genetic Evidence for Role of Carotenoids in Age-Related Macular Degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS) Free
PDF
Kristin J. Meyers; Julie A. Mares; Robert P. Igo, Jr; Barbara Truitt; Zhe Liu; Amy E. Millen; Michael Klein; Elizabeth J. Johnson; Corinne D. Engelman; Chitra K. Karki; Barbara Blodi; Karen Gehrs; Lesley Tinker; Robert Wallace; Jennifer Robinson; Erin S. LeBlanc; Gloria Sarto; Paul S. Bernstein; John Paul SanGiovanni; Sudha K. Iyengar
Tags: age-related macular degeneration, carotenoids, lutein, genes, eye diseases
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 587-599. doi:10.1167/iovs.13-13216

Cornea

Lipid-Modifying Enzymes in Human Tear Fluid and Corneal Epithelial Stress Response Free
PDF
Alexandra Robciuc; Antti H. Rantamäki; Matti Jauhiainen; Juha M. Holopainen
Tags: cornea, enzymes, lipids, phospholipase, stress
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 16-24. doi:10.1167/iovs.13-12577
Association and Familial Segregation of CTG18.1 Trinucleotide Repeat Expansion of TCF4 Gene in Fuchs' Endothelial Corneal Dystrophy Free
PDF
V. Vinod Mootha; Xin Gong; Hung-Chih Ku; Chao Xing
Tags: alleles, endothelium, family, genes, hereditary corneal dystrophy
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 33-42. doi:10.1167/iovs.13-12611
Neuropeptides Released From Trigeminal Neurons Promote the Stratification of Human Corneal Epithelial Cells Free
PDF
Ji-Ae Ko; Yukari Mizuno; Chihiro Ohki; Tai-ichiro Chikama; Koh-Hei Sonoda; Yoshiaki Kiuchi
Tags: coculture techniques, collagen, corneal epithelial cells, neurons, neuropeptides
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 125-133. doi:10.1167/iovs.13-12642
Normative Values for Corneal Densitometry Analysis by Scheimpflug Optical Assessment Free
PDF
Sorcha Ní Dhubhghaill; Jos J. Rozema; Sien Jongenelen; Irene Ruiz Hidalgo; Nadia Zakaria; Marie-José Tassignon
Tags: cornea, densitometry, optics
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 162-168. doi:10.1167/iovs.13-13236
Endothelial Cell MicroRNA Expression in Human Late-Onset Fuchs' Dystrophy Free
PDF
Mario Matthaei; Jianfei Hu; Laura Kallay; Charles G. Eberhart; Claus Cursiefen; Jiang Qian; Eva-Maria Lackner; Albert S. Jun
Tags: endothelium, micrornas, endothelial cells
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 216-225. doi:10.1167/iovs.13-12689
The Ocular Surface Phenotype of Muc5ac and Muc5b Null Mice Free
PDF
Christina Kaiser Marko; Ann S. Tisdale; Sandra Spurr-Michaud; Christopher Evans; Ilene K. Gipson
Tags: mice, mice, knockout, phenotype, mucins, goblet cells
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 291-300. doi:10.1167/iovs.13-13194
Involvement of Cyclin D and p27 in Cell Proliferation Mediated by ROCK Inhibitors Y-27632 and Y-39983 During Corneal Endothelium Wound Healing Free