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Research Highlight

A Significant Advance in the Biomechanical Evaluation of the Optic Nerve Head Free
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Thao D. Nguyen
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 215. doi:https://doi.org/10.1167/iovs.13-13789
Toward an Improved Understanding of the Physiology of Aqueous Humor Flow Free
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J. Cameron Millar
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 404. doi:https://doi.org/10.1167/iovs.13-13753

Anatomy and Pathology/Oncology

Enzymatic Degradation Identifies Components Responsible for the Structural Properties of the Vitreous Body Free
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Benjamen A. Filas; Qianru Zhang; Ruth J. Okamoto; Ying-Bo Shui; David C. Beebe
Tags: vitreous body, catabolism
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 55-63. doi:https://doi.org/10.1167/iovs.13-13026
Ocular Changes in TgF344-AD Rat Model of Alzheimer's Disease Free
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Yuchun Tsai; Bin Lu; Alexander V. Ljubimov; Sergey Girman; Fred N. Ross-Cisneros; Alfredo A. Sadun; Clive N. Svendsen; Robert M. Cohen; Shaomei Wang
Tags: alzheimer's disease, antibodies, choroid, eye, rats
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 523-534. doi:https://doi.org/10.1167/iovs.13-12888

Biochemistry and Molecular Biology

Biophysical and Morphological Evaluation of Human Normal and Dry Eye Meibum Using Hot Stage Polarized Light Microscopy Free
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Igor A. Butovich; Hua Lu; Anne McMahon; Howard Ketelson; Michelle Senchyna; David Meadows; Elaine Campbell; Mike Molai; Emily Linsenbardt
Tags: birefringence, dry eye syndromes, lipids, proteins, temperature
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 87-101. doi:https://doi.org/10.1167/iovs.13-13355
Effect of Nerve Growth Factor on the In Vitro Induction of Apoptosis of Human Conjunctival Epithelial Cells by Hyperosmolar Stress Free
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Soon-Suk Kang; Sae-Jin Ha; Eun-Soon Kim; Jin-A Shin; Jae Yong Kim; Hungwon Tchah
Tags: apoptosis, conjunctival epithelial cells, hyperosmolality, hyperosmolar hyperglycemia, nerve growth factors
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 535-541. doi:https://doi.org/10.1167/iovs.13-12459

Clinical and Epidemiologic Research

Corneal Biomechanical Properties and Glaucoma-Related Quantitative Traits in the EPIC-Norfolk Eye Study Free
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Anthony P. Khawaja; Michelle P. Y. Chan; David C. Broadway; David F. Garway-Heath; Robert Luben; Jennifer L. Y. Yip; Shabina Hayat; Kay-Tee Khaw; Paul J. Foster
Tags: cornea, corneal hysteresis, eye, glaucoma, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 117-124. doi:https://doi.org/10.1167/iovs.13-13290
Accuracy of Rural Refractionists in Western China Free
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Zhongqiang Zhou; Junxia Zeng; Xiaochen Ma; Xiaopeng Pang; Hongmei Yi; Qianyun Chen; Mirjam E. Meltzer; Mingguang He; Scott Rozelle; Nathan Congdon
Tags: child, china, eye, refraction, refractive errors
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 154-161. doi:https://doi.org/10.1167/iovs.13-13250
Reduced Fluorescein Angiography and Fundus Photography Use in the Management of Neovascular Macular Degeneration and Macular Edema During the Past Decade Free
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Eric W. Schneider; Prithvi Mruthyunjaya; Nidhi Talwar; Kristen Harris Nwanyanwu; Bin Nan; Joshua D. Stein
Tags: diagnostic imaging, diagnostic techniques and procedures, edema, fluorescein angiography, fundus photography
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 542-549. doi:https://doi.org/10.1167/iovs.13-13034
Subfoveal Choroidal Thickness in 1323 Children Aged 11 to 12 Years and Association With Puberty: The Copenhagen Child Cohort 2000 Eye Study Free
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Xiao Qiang Li; Pia Jeppesen; Michael Larsen; Inger Christine Munch
Tags: child, cohort studies, eye, puberty, body weight
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 550-555. doi:https://doi.org/10.1167/iovs.13-13476
Genetic Evidence for Role of Carotenoids in Age-Related Macular Degeneration in the Carotenoids in Age-Related Eye Disease Study (CAREDS) Free
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Kristin J. Meyers; Julie A. Mares; Robert P. Igo, Jr; Barbara Truitt; Zhe Liu; Amy E. Millen; Michael Klein; Elizabeth J. Johnson; Corinne D. Engelman; Chitra K. Karki; Barbara Blodi; Karen Gehrs; Lesley Tinker; Robert Wallace; Jennifer Robinson; Erin S. LeBlanc; Gloria Sarto; Paul S. Bernstein; John Paul SanGiovanni; Sudha K. Iyengar
Tags: age-related macular degeneration, carotenoids, lutein, genes, eye diseases
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 587-599. doi:https://doi.org/10.1167/iovs.13-13216

Cornea

Lipid-Modifying Enzymes in Human Tear Fluid and Corneal Epithelial Stress Response Free
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Alexandra Robciuc; Antti H. Rantamäki; Matti Jauhiainen; Juha M. Holopainen
Tags: cornea, enzymes, lipids, phospholipase, stress
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 16-24. doi:https://doi.org/10.1167/iovs.13-12577
Association and Familial Segregation of CTG18.1 Trinucleotide Repeat Expansion of TCF4 Gene in Fuchs' Endothelial Corneal Dystrophy Free
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V. Vinod Mootha; Xin Gong; Hung-Chih Ku; Chao Xing
Tags: alleles, endothelium, family, genes, hereditary corneal dystrophy
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 33-42. doi:https://doi.org/10.1167/iovs.13-12611
Neuropeptides Released From Trigeminal Neurons Promote the Stratification of Human Corneal Epithelial Cells Free
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Ji-Ae Ko; Yukari Mizuno; Chihiro Ohki; Tai-ichiro Chikama; Koh-Hei Sonoda; Yoshiaki Kiuchi
Tags: coculture techniques, collagen, corneal epithelial cells, neurons, neuropeptides
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 125-133. doi:https://doi.org/10.1167/iovs.13-12642
Normative Values for Corneal Densitometry Analysis by Scheimpflug Optical Assessment Free
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Sorcha Ní Dhubhghaill; Jos J. Rozema; Sien Jongenelen; Irene Ruiz Hidalgo; Nadia Zakaria; Marie-José Tassignon
Tags: cornea, densitometry, optics
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 162-168. doi:https://doi.org/10.1167/iovs.13-13236
Endothelial Cell MicroRNA Expression in Human Late-Onset Fuchs' Dystrophy Free
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Mario Matthaei; Jianfei Hu; Laura Kallay; Charles G. Eberhart; Claus Cursiefen; Jiang Qian; Eva-Maria Lackner; Albert S. Jun
Tags: endothelium, micrornas, endothelial cells
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 216-225. doi:https://doi.org/10.1167/iovs.13-12689
The Ocular Surface Phenotype of Muc5ac and Muc5b Null Mice Free
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Christina Kaiser Marko; Ann S. Tisdale; Sandra Spurr-Michaud; Christopher Evans; Ilene K. Gipson
Tags: mice, mice, knockout, phenotype, mucins, goblet cells
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 291-300. doi:https://doi.org/10.1167/iovs.13-13194
Involvement of Cyclin D and p27 in Cell Proliferation Mediated by ROCK Inhibitors Y-27632 and Y-39983 During Corneal Endothelium Wound Healing Free
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Naoki Okumura; Shinichiro Nakano; EunDuck P. Kay; Ryohei Numata; Aya Ota; Yoshihiro Sowa; Toshiyuki Sakai; Morio Ueno; Shigeru Kinoshita; Noriko Koizumi
Tags: cell proliferation, corneal endothelium, cyclin d1, wound healing, ki-67 antigen
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 318-329. doi:https://doi.org/10.1167/iovs.13-12225
Impact of Keratoconus in the Better Eye and the Worse Eye on Vision-Related Quality of Life Free
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Srujana Sahebjada; Eva K. Fenwick; Jing Xie; Grant R. Snibson; Mark D. Daniell; Paul N. Baird
Tags: eye, keratoconus, quality of life, vision
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 412-416. doi:https://doi.org/10.1167/iovs.13-12929

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Tear Proteomic Analysis of Patients With Type 2 Diabetes and Dry Eye Syndrome by Two-Dimensional Nano-Liquid Chromatography Coupled With Tandem Mass Spectrometry Free
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Bing Li; Minjie Sheng; Liqi Xie; Feng Liu; Guoquan Yan; Weifang Wang; Anjuan Lin; Fei Zhao; Yihui Chen
Tags: diabetes mellitus, diabetes mellitus, type 2, dry eye syndromes, proteins, chromatography
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 177-186. doi:https://doi.org/10.1167/iovs.13-12080
Horizontal and Vertical Optokinetic Eye Movements in Macaque Monkeys With Infantile Strabismus: Directional Bias and Crosstalk Free
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Fatema Ghasia; Lawrence Tychsen
Tags: cercopithecidae, eye, eye movement, macaca, motion
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 265-274. doi:https://doi.org/10.1167/iovs.13-12330
Vertical and Oblique Saccade Disconjugacy in Strabismus Free
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Mark M. G. Walton; Seiji Ono; Michael Mustari
Tags: cercopithecidae, eye, saccades, strabismus
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 275-290. doi:https://doi.org/10.1167/iovs.13-13473
Crouzon Syndrome: Relationship of Rectus Muscle Pulley Location to Pattern Strabismus Free
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Avery H. Weiss; James Phillips; John P. Kelly
Tags: apert-crouzon syndrome, extra-ocular rectus muscles, eye, strabismus, exotropia
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 310-317. doi:https://doi.org/10.1167/iovs.13-13069
The Effect of Font Size on Reading Performance in Strabismic Amblyopia: An Eye Movement Investigation Free
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Evgenia Kanonidou; Irene Gottlob; Frank A. Proudlock
Tags: eye movement, reading (activity), strabismic amblyopia, amblyopia, eye
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 451-459. doi:https://doi.org/10.1167/iovs.13-13257

Genetics

Suggestive Association With Ocular Phoria at Chromosome 6p22 Free
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Jenny M. Bosten; Ruth E. Hogg; Gary Bargary; Patrick T Goodbourn; Adam J. Lawrance-Owen; John D. Mollon
Tags: genome-wide association study, strabismus
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 345-352. doi:https://doi.org/10.1167/iovs.13-12879
Correction of the Crb1rd8 Allele and Retinal Phenotype in C57BL/6N Mice Via TALEN-Mediated Homology-Directed Repair Free
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Benjamin E. Low; Mark P. Krebs; J. Keith Joung; Shengdar Q. Tsai; Patsy M. Nishina; Michael V. Wiles
Tags: alleles, homologous recombinational dna repair, mice, mice, inbred c57bl, mutation
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 387-395. doi:https://doi.org/10.1167/iovs.13-13278

Glaucoma

Eye-Specific IOP-Induced Displacements and Deformations of Human Lamina Cribrosa Free
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Ian A. Sigal; Jonathan L. Grimm; Ning-Jiun Jan; Korey Reid; Don S. Minckler; Donald J. Brown
Tags: displacements, eye, intraocular pressure, compression, raised intraocular pressure
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 1-15. doi:https://doi.org/10.1167/iovs.13-12724
Examining Visual Field Loss in Patients in Glaucoma Clinics During Their Predicted Remaining Lifetime Free
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Luke J. Saunders; Richard A. Russell; James F. Kirwan; Andrew I. McNaught; David P. Crabb
Tags: blindness, glaucoma, eye
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 102-109. doi:https://doi.org/10.1167/iovs.13-13006
Effect of Ginkgo Biloba on Visual Field and Contrast Sensitivity in Chinese Patients With Normal Tension Glaucoma: A Randomized, Crossover Clinical Trial Free
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Xinxing Guo; Xiangbin Kong; Rui Huang; Ling Jin; Xiaohu Ding; Mingguang He; Xing Liu; Mehul Chimanlal Patel; Nathan G. Congdon
Tags: chinese (other dialects), chinese people, contrast sensitivity, ginkgo biloba, glaucoma
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 110-116. doi:https://doi.org/10.1167/iovs.13-13168
Topographic Characteristics of Optic Disc Hemorrhage in Primary Open-Angle Glaucoma Free
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Young Kook Kim; Ki Ho Park; Beong Wook Yoo; Hee Chan Kim
Tags: hemorrhage, open-angle glaucoma, optic disk, eye
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 169-176. doi:https://doi.org/10.1167/iovs.13-13192
Changes in the Lamina and Prelamina After Intraocular Pressure Reduction in Patients With Primary Open-Angle Glaucoma and Acute Primary Angle-Closure Free
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Hae-Young Lopilly Park; Hye-Young Shin; Kyoung In Jung; Chan Kee Park
Tags: intraocular pressure, open-angle glaucoma, optic disk
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 233-239. doi:https://doi.org/10.1167/iovs.12-10329
Results of a Patient-Directed Survey on Frequency of Family History of Glaucoma in 2170 Patients Free
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Gwendolyn Gramer; Bernhard H. F. Weber; Eugen Gramer
Tags: glaucoma, open-angle glaucoma, family history
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 259-264. doi:https://doi.org/10.1167/iovs.13-13020
Comparison of Posture-Induced Intraocular Pressure Changes in Medically Treated and Surgically Treated Eyes With Open-Angle Glaucoma Free
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Akira Sawada; Tetsuya Yamamoto
Tags: eye, glaucoma, intraocular pressure, open-angle glaucoma, posture
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 446-450. doi:https://doi.org/10.1167/iovs.13-13030
Alterations in the Neural and Connective Tissue Components of Glaucomatous Cupping After Glaucoma Surgery Using Swept-Source Optical Coherence Tomography Free
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Munemitsu Yoshikawa; Tadamichi Akagi; Masanori Hangai; Hanako Ohashi-Ikeda; Kohei Takayama; Satoshi Morooka; Yugo Kimura; Noriko Nakano; Nagahisa Yoshimura
Tags: cupping therapy, glaucoma, glaucoma surgery, intraocular pressure, optic disk
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 477-484. doi:https://doi.org/10.1167/iovs.13-11897
Estimation of Retinal Ganglion Cell Loss in Glaucomatous Eyes With a Relative Afferent Pupillary Defect Free
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Andrew J. Tatham; Daniel Meira-Freitas; Robert N. Weinreb; Amir H. Marvasti; Linda M. Zangwill; Felipe A. Medeiros
Tags: eye, glaucoma, relative afferent pupillary defect, retinal ganglion cells
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 513-522. doi:https://doi.org/10.1167/iovs.13-12921
Longitudinal Detection of Optic Nerve Head Changes by Spectral Domain Optical Coherence Tomography in Early Experimental Glaucoma Free
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Lin He; Hongli Yang; Stuart K. Gardiner; Galen Williams; Christy Hardin; Nicholas G. Strouthidis; Brad Fortune; Claude F. Burgoyne
Tags: eye, glaucoma, optic disk, optical coherence tomography, scanning laser polarimetry
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 574-586. doi:https://doi.org/10.1167/iovs.13-13245
Dynamics, Alterations, and Consequences of Minimally Invasive Intraocular Pressure Elevation in Rats Free
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Oliver W. Gramlich; Theresa C. S. Lueckner; Maren Kriechbaum; Julia Teister; Xue Tao; Harald D. von Pein; Norbert Pfeiffer; Franz H. Grus
Tags: intraocular pressure, rats, recurrence, diagnostic imaging, eye
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 600-611. doi:https://doi.org/10.1167/iovs.13-12714
Improving Glaucoma Detection Using Spatially Correspondent Clusters of Damage and by Combining Standard Automated Perimetry and Optical Coherence Tomography Free
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Ali S. Raza; Xian Zhang; Carlos G. V. De Moraes; Charles A. Reisman; Jeffrey M. Liebmann; Robert Ritch; Donald C. Hood
Tags: glaucoma, optical coherence tomography, perimetry
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 612-624. doi:https://doi.org/10.1167/iovs.13-12351

Immunology and Microbiology

Pseudomonas aeruginosa MucD Protease Mediates Keratitis by Inhibiting Neutrophil Recruitment and Promoting Bacterial Survival Free
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Yuji Mochizuki; Takashi Suzuki; Naoko Oka; Yuan Zhang; Yasuhito Hayashi; Naoki Hayashi; Naomasa Gotoh; Yuichi Ohashi
Tags: endopeptidases, keratitis, neutrophil infiltration, peptide hydrolases, pseudomonas aeruginosa
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 240-246. doi:https://doi.org/10.1167/iovs.13-13151
Fcγ Receptor Upregulation Is Associated With Immune Complex Inflammation in the Mouse Retina and Early Age-Related Macular Degeneration Free
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Salome Murinello; Robert F. Mullins; Andrew J. Lotery; V. Hugh Perry; Jessica L. Teeling
Tags: antigen-antibody complex, inflammation, mice, retina, immunoglobulin g
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 247-258. doi:https://doi.org/10.1167/iovs.13-11821

Low Vision

Visually Impaired Drivers Who Use Bioptic Telescopes: Self-Assessed Driving Skills and Agreement With On-Road Driving Evaluation Free
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Cynthia Owsley; Gerald McGwin, Jr; Jennifer Elgin; Joanne M. Wood
Tags: driving assessment, telescope, visual impairment
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 330-336. doi:https://doi.org/10.1167/iovs.13-13520
Driving With Hemianopia: III. Detection of Stationary and Approaching Pedestrians in a Simulator Free
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Concetta F. Alberti; Eli Peli; Alex R. Bowers
Tags: hemianopsia, pedestrian, simulators, reaction time
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 368-374. doi:https://doi.org/10.1167/iovs.13-12737

Multidisciplinary Ophthalmic Imaging

Relationship Between Rate of Posterior Uveal Melanoma Flattening Following Plaque Radiotherapy and Gene Expression Profile Class of Tumor Cells Free
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Zélia M. Corrêa; James J. Augsburger
Tags: gene expression profiling, malignant melanoma of choroid, neoplasms, plaque radiotherapy, tumor cells
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 556-559. doi:https://doi.org/10.1167/iovs.13-13381
Differential Vulnerability of Retinal Layers to Early Age-Related Macular Degeneration: Evidence by SD-OCT Segmentation Analysis Free
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Maria Cristina Savastano; Angelo Maria Minnella; Antonello Tamburrino; Gaspare Giovinco; Salvatore Ventre; Benedetto Falsini
Tags: age-related macular degeneration, emotional vulnerability, eye
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 560-566. doi:https://doi.org/10.1167/iovs.13-12172

Nantotechnology and Regenerative Medicine

Combinatorial Hedgehog and Mitogen Signaling Promotes the In Vitro Expansion but Not Retinal Differentiation Potential of Retinal Progenitor Cells Free
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Randy Ringuette; Yaping Wang; Michael Atkins; Alan J. Mears; Keqin Yan; Valerie A. Wallace
Tags: erinaceidae, growth factor, mice, mitogens, retina
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 43-54. doi:https://doi.org/10.1167/iovs.13-12592
Optimal Isolation and Xeno-Free Culture Conditions for Limbal Stem Cell Function Free
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Kalliopi Stasi; DaVida Goings; Jiayan Huang; Lindsay Herman; Filipa Pinto; Russell C. Addis; Dahlia Klein; Giacomina Massaro-Giordano; John D. Gearhart
Tags: epithelial cells, immunocytochemistry, patient isolation, reverse transcriptase polymerase chain reaction, social isolation
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 375-386. doi:https://doi.org/10.1167/iovs.13-12517

Physiology and Pharmacology

Nonpigmented Ciliary Epithelial Cells Respond to Acetazolamide by a Soluble Adenylyl Cyclase Mechanism Free
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Mohammad Shahidullah; Amritlal Mandal; Guojun Wei; Lonny R. Levin; Jochen Buck; Nicholas A. Delamere
Tags: acetazolamide, cyclic amp, adenylate cyclase, recovery of function, buffers
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 187-197. doi:https://doi.org/10.1167/iovs.13-12717
The Effect of Vasopressin on Ciliary Blood Flow and Aqueous Flow Free
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Barbara Bogner; Christian Runge; Clemens Strohmaier; Andrea Trost; Birgit Tockner; Jeffrey W. Kiel; Falk Schroedl; Herbert A. Reitsamer
Tags: fluid flow, intraocular pressure, vascular flow, vasopressins, infusion procedures
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 396-403. doi:https://doi.org/10.1167/iovs.13-13286
Continuous Response of Optic Nerve Head Blood Flow to Increase of Arterial Blood Pressure in Humans Free
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Christophe Chiquet; Tiffany Lacharme; Charles Riva; Ahmed Almanjoumi; Florent Aptel; Hafide Khayi; Nathalie Arnol; Jean-Paul Romanet; Martial Geiser
Tags: arterial pressure, optic disk, perfusion, vascular flow
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 485-491. doi:https://doi.org/10.1167/iovs.13-12975
Role of the M3 Muscarinic Acetylcholine Receptor Subtype in Murine Ophthalmic Arteries After Endothelial Removal Free
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Adrian Gericke; Andreas Steege; Caroline Manicam; Tobias Böhmer; Jürgen Wess; Norbert Pfeiffer
Tags: endothelium, muscarinic acetylcholine receptor, ophthalmic artery, mice, acetylcholine
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 625-631. doi:https://doi.org/10.1167/iovs.13-13549

Retina

A Novel Color Vision Test for Detection of Diabetic Macular Edema Free
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Young Joo Shin; Kyu Hyung Park; Jeong-Min Hwang; Won Ryang Wee; Jin Hak Lee; In Bum Lee; Joon Young Hyon
Tags: color vision examination, diabetic macular edema, edema, color vision
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 25-32. doi:https://doi.org/10.1167/iovs.13-11698
Comparison of Macular Choroidal Thickness in Adult Onset Foveomacular Vitelliform Dystrophy and Age-Related Macular Degeneration Free
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Florence Coscas; Nathalie Puche; Gabriel Coscas; Mayer Srour; Catherine Français; Agnes Glacet-Bernard; Giuseppe Querques; Eric H. Souied
Tags: adult, age-related macular degeneration, eye, vitelliform dystrophy, choroid
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 64-69. doi:https://doi.org/10.1167/iovs.13-12931
Intersublaminar Vascular Plexus: The Correlation of Retinal Blood Vessels With Functional Sublaminae of the Inner Plexiform Layer Free
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Elena Ivanova; Abduqodir H. Toychiev; Christopher W. Yee; Botir T. Sagdullaev
Tags: cholinergic agents, khat, retina, retinal vessels, neurons
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 78-86. doi:https://doi.org/10.1167/iovs.13-13196
Retinal Vessel Tortuosity Associated With Central Retinal Vein Occlusion: An Optical Coherence Tomography Study Free
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Yuki Muraoka; Akitaka Tsujikawa; Kyoko Kumagai; Yumiko Akagi-Kurashige; Ken Ogino; Tomoaki Murakami; Kazuaki Miyamoto; Nagahisa Yoshimura
Tags: central retinal vein occlusion, eye, optical coherence tomography, retinal vessel tortuosity, retinal vessels
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 134-141. doi:https://doi.org/10.1167/iovs.13-13201
Allergy Is a Protective Factor Against Age-Related Macular Degeneration Free
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Tina Ristau; Lebriz Ersoy; Yara Lechanteur; Anneke I. den Hollander; Mohamed R. Daha; Moritz Hahn; Carel B. Hoyng; Sascha Fauser
Tags: age-related macular degeneration, hypersensitivity, immediate hypersensitivity, cohort studies, protective factors
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 210-214. doi:https://doi.org/10.1167/iovs.13-13248
Macular Microstructures and Prognostic Factors in Myopic Subretinal Hemorrhages Free
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Tomoko Asai; Yasushi Ikuno; Kohji Nishida
Tags: hemorrhage, melanocyte stimulating hormone, prognostic factors, eye
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 226-232. doi:https://doi.org/10.1167/iovs.13-12658
Systemic Upregulation of PDGF-B in Patients With Neovascular AMD Free
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Claus Zehetner; Rudolf Kirchmair; Sabrina B. Neururer; Martina T. Kralinger; Nikolaos E. Bechrakis; Gerhard F. Kieselbach
Tags: exudative age-related macular degeneration, platelet-derived growth factor, vascular endothelial growth factor a, up-regulation (physiology), plasma
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 337-344. doi:https://doi.org/10.1167/iovs.13-12978
Autoregulation of Retinal Blood Flow in Response to Decreased Ocular Perfusion Pressure in Cats: Comparison of the Effects of Increased Intraocular Pressure and Systemic Hypotension Free
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Tomofumi Tani; Taiji Nagaoka; Seigo Nakabayashi; Takafumi Yoshioka; Akitoshi Yoshida
Tags: adaptive testing, cats, homeostasis, hypotension, perfusion
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 360-367. doi:https://doi.org/10.1167/iovs.13-12591
Is the Association Between Smoking and the Retinal Venular Diameter Reversible Following Smoking Cessation? Free
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Masahide Yanagi; Munechika Misumi; Ryo Kawasaki; Ikuno Takahashi; Katsumasa Itakura; Saeko Fujiwara; Masazumi Akahoshi; Kazuo Neriishi; Tien Yin Wong; Yoshiaki Kiuchi
Tags: diameter, smoking, smoking cessation
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 405-411. doi:https://doi.org/10.1167/iovs.13-12512
Quantitative Analysis of Diabetic Macular Ischemia Using Optical Coherence Tomography Free
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Dawn A. Sim; Pearse A. Keane; Simon Fung; Michael Karampelas; Srinivas R. Sadda; Marcus Fruttiger; Praveen J. Patel; Adnan Tufail; Catherine A. Egan
Tags: diabetes mellitus, ischemia, optical coherence tomography, eye
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 417-423. doi:https://doi.org/10.1167/iovs.13-12677
Long-Term Retinal Cone Survival and Delayed Alteration of the Cone Mosaic in a Transgenic Mouse Model of Stargardt-Like Dystrophy (STGD3) Free
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Sharee Kuny; Marc-André Filion; Miyoung Suh; Frédéric Gaillard; Yves Sauvé
Tags: mice, mosaicism, opsin, retinal cone, tissue degeneration
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 424-439. doi:https://doi.org/10.1167/iovs.13-13457
Changes in Choroidal Thickness After Systemic Administration of High-Dose Corticosteroids: A Pilot Study Free
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Jeong Mo Han; Jeong-Min Hwang; Ji Soo Kim; Kyu Hyung Park; Se Joon Woo
Tags: adrenal corticosteroids, glucocorticoids, mineralocorticoids, pilot projects
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 440-445. doi:https://doi.org/10.1167/iovs.13-12854
Effects of Simvastatin on Retinal Structure and Function of a High-Fat Atherogenic Mouse Model of Thickened Bruch's Membrane Free
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Veluchamy A. Barathi; Sia W. Yeo; Robyn H. Guymer; Tien Y. Wong; Chi D. Luu
Tags: bruch's basal membrane, mice, retina, simvastatin
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 460-468. doi:https://doi.org/10.1167/iovs.13-11636
Cfh Genotype Interacts With Dietary Glycemic Index to Modulate Age-Related Macular Degeneration-Like Features in Mice Free
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Sheldon Rowan; Karen Weikel; Min-Lee Chang; Barbara A. Nagel; Jeffrey S. Thinschmidt; Amanda Carey; Maria B. Grant; Steven J. Fliesler; Donald Smith; Allen Taylor
Tags: diet, genes, genotype, mice, tissue degeneration
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 492-501. doi:https://doi.org/10.1167/iovs.13-12413
Intraocular Pharmacokinetics of Ranibizumab in Vitrectomized Versus Nonvitrectomized Eyes Free
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Seong Joon Ahn; Jeeyun Ahn; Sunyoung Park; Hyuncheol Kim; Duck Jin Hwang; Ji Hyun Park; Ji Yeon Park; Jae Yong Chung; Kyu Hyung Park; Se Joon Woo
Tags: eye, ranibizumab, pharmacokinetics, vitreous body
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 567-573. doi:https://doi.org/10.1167/iovs.13-13054

Retinal Cell Biology

Retinoid Uptake, Processing, and Secretion in Human iPS-RPE Support the Visual Cycle Free
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Alberto Muñiz; Whitney A. Greene; Mark L. Plamper; Jae Hyek Choi; Anthony J. Johnson; Andrew T. Tsin; Heuy-Ching Wang
Tags: bodily secretions, esters, retinoids, vitamin a, retinaldehyde
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 198-209. doi:https://doi.org/10.1167/iovs.13-11740

Translational

Swine Cone and Rod Precursors Arise Sequentially and Display Sequential and Transient Integration and Differentiation Potential Following Transplantation Free
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Wei Wang; Liang Zhou; Sang Joon Lee; Yongqing Liu; Juan Fernandez de Castro; Douglas Emery; Eric Vukmanic; Henry J. Kaplan; Douglas C. Dean
Tags: embryo, retina, retinal cone, rod photoreceptors, suidae
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 301-309. doi:https://doi.org/10.1167/iovs.13-12600
Biocompatible Reverse Thermal Gel Sustains the Release of Intravitreal Bevacizumab In Vivo Free
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Britta M. Rauck; Thomas R. Friberg; Carlos A. Medina Mendez; Daewon Park; Veeral Shah; Richard A. Bilonick; Yadong Wang
Tags: bevacizumab, gel, eye
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 469-476. doi:https://doi.org/10.1167/iovs.13-13120
Effect of Coadministration of Neuronal Growth Factors on Neuroglial Differentiation of Bone Marrow–Derived Stem Cells in the Ischemic Retina Free
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Nitza Goldenberg-Cohen; Bat-Chen R. Avraham-Lubin; Tamilla Sadikov; Nadir Askenasy
Tags: bone marrow, brain-derived neurotrophic factor, ciliary neurotrophic factor, growth factor, ischemia
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 502-512. doi:https://doi.org/10.1167/iovs.13-12223

Visual Psychophysics and Physiological Optics

Impact of Pupil Transmission Apodization on Presbyopic Through-Focus Visual Performance With Spherical Aberration Free
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Len Zheleznyak; HaeWon Jung; Geunyoung Yoon
Tags: image quality, pupil
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 70-77. doi:https://doi.org/10.1167/iovs.13-13107
Characterization of Field Loss Based on Microperimetry Is Predictive of Face Recognition Difficulties Free
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Thomas S. A. Wallis; Christopher Patrick Taylor; Jennifer Wallis; Mary Lou Jackson; Peter J. Bex
Tags: face, facial recognition, vision, visual impairment, perimetry
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 142-153. doi:https://doi.org/10.1167/iovs.13-12420
Assessing Spatial and Temporal Properties of Perimetric Stimuli for Resistance to Clinical Variations in Retinal Illumination Free
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William H. Swanson; Mitchell W. Dul; Douglas G. Horner; Tiffany Liu; Irene Tran
Tags: contrast sensitivity, light, lighting, statutes and laws, spatial frequency
Investigative Ophthalmology & Visual Science January 2014, Vol.55, 353-359. doi:https://doi.org/10.1167/iovs.13-11640
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