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Research Highlight

A Spontaneous CNV Model Provides New Tool to Understand AMD Free
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Gerard Rodrigues
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3720. doi:https://doi.org/10.1167/iovs.14-14827
Closing the Clinical-Radiological Paradox Using the Visual Pathway in Multiple Sclerosis Free
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Pablo Villoslada
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3765. doi:https://doi.org/10.1167/iovs.14-14765
Angiotensin-Converting Enzyme 2: Potential Target for the Development of Novel Ocular Therapies Free
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Anderson José Ferreira
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3819. doi:https://doi.org/10.1167/iovs.14-14847

Anatomy and Pathology/Oncology

Expression of Vascular Endothelial Growth Factor in Human Ocular Adnexal Lymphoma Free
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Satoshi Kinoshita; Satoru Kase; Ryo Ando; Zhenyu Dong; Junichi Fukuhara; Yoko Dong; Saori Inafuku; Kousuke Noda; Mika Noda; Atsuhiro Kanda; Susumu Ishida
Tags: ocular adnexal lymphoma, vascular endothelial growth factor a, conjunctiva
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3461-3467. doi:https://doi.org/10.1167/iovs.13-13510
Morphology of Retinal Vessels in Patients With Optic Nerve Head Drusen and Optic Disc Edema Free
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Anastasia V. Pilat; Frank A. Proudlock; Rebecca J. McLean; Mark C. Lawden; Irene Gottlob
Tags: diameter, language morphology, morphology, optic disk drusen, papilledema
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3484-3490. doi:https://doi.org/10.1167/iovs.14-13903
Pathologic Alterations of the Outer Retina in Streptozotocin-Induced Diabetes Free
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Anna Énzsöly; Arnold Szabó; Orsolya Kántor; Csaba Dávid; Péter Szalay; Klaudia Szabó; Ágoston Szél; János Németh; Ákos Lukáts
Tags: diabetes mellitus, retina, diabetes mellitus, type 2, retinal cone, streptozocin
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3686-3699. doi:https://doi.org/10.1167/iovs.13-13562
STAT6-Mediated Keratitis and Blepharitis: A Novel Murine Model of Ocular Atopic Dermatitis Free
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Matthew J. Turner; Sonia DaSilva-Arnold; Na Luo; Xinyao Hu; Callah C. West; Lou Sun; Christopher Hill; Joshua Bradish; Mark H. Kaplan; Jeffrey B. Travers; Yang Sun
Tags: atopic dermatitis, blepharitis, keratitis, mice, cornea
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3803-3808. doi:https://doi.org/10.1167/iovs.13-13685

Biochemistry and Molecular Biology

Human Trabecular Meshwork Sphingolipid and Ceramide Profiles and Potential Latent Fungal Commensalism Free
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Ayman J. Aljohani; Genea Edwards; Yenifer Guerra; Sander Dubovy; Darlene Miller; Richard K. Lee; Sanjoy K. Bhattacharya
Tags: ceramides, lipids, open-angle glaucoma, sphingolipids, symbiosis
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3413-3422. doi:https://doi.org/10.1167/iovs.13-13570
Identification of the Cellular Mechanisms That Modulate Trafficking of Frizzled Family Receptor 4 (FZD4) Missense Mutants Associated With Familial Exudative Vitreoretinopathy Free
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Reham M. Milhem; Salma Ben-Salem; Lihadh Al-Gazali; Bassam R. Ali
Tags: familial exudative vitreoretinopathies, family, proteins, mutation
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3423-3431. doi:https://doi.org/10.1167/iovs.14-13885
Activation of Bax in Three Models of Retinitis Pigmentosa Free
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Antonella Comitato; Daniela Sanges; Alessandra Rossi; Marian M. Humphries; Valeria Marigo
Tags: calpain, cathepsin d, retinitis pigmentosa, photoreceptors, western blotting
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3555-3561. doi:https://doi.org/10.1167/iovs.14-13917
Effects of the Loss of Conjunctival Muc16 on Corneal Epithelium and Stroma in Mice Free
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Kumi Shirai; Yuka Okada; Dong-Joo Cheon; Masayasu Miyajima; Richard R. Behringer; Osamu Yamanaka; Shizuya Saika
Tags: conjunctiva, cornea, corneal epithelium, mice
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3626-3637. doi:https://doi.org/10.1167/iovs.13-12955
Essential Role of the Chaperonin CCT in Rod Outer Segment Biogenesis Free
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Satyabrata Sinha; Marycharmain Belcastro; Poppy Datta; Seongjin Seo; Maxim Sokolov
Tags: chaperonin, origin of life, proteins, rod outer segments, rod photoreceptors
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3775-3785. doi:https://doi.org/10.1167/iovs.14-13889
Regulation of Retinal Inflammation by Rhythmic Expression of MiR-146a in Diabetic Retina Free
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Qi Wang; Svetlana N. Bozack; Yuanqing Yan; Michael E. Boulton; Maria B. Grant; Julia V. Busik
Tags: diabetes mellitus, inflammation, retina, rhythm, intercellular adhesion molecule 1
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3986-3994. doi:https://doi.org/10.1167/iovs.13-13076

Clinical and Epidemiologic Research

Development of a Chinese Version of the Ocular Comfort Index Free
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Cecilia Chao; Blanka Golebiowski; Yu Cui; Fiona Stapleton
Tags: chinese (other dialects), dry eye syndromes, rasch model, reliability
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3562-3571. doi:https://doi.org/10.1167/iovs.14-14276
Retinal Vessel Oxygen Saturation Increases After Vitrectomy Free
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Laurence Shen Lim; Licia Tan; Shamira Perera
Tags: oxygen saturation measurement, retinal vessels, surgical procedures, operative, vitrectomy
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3851-3856. doi:https://doi.org/10.1167/iovs.14-14152

Cornea

Comparative Analysis of Two Femtosecond LASIK Platforms Using iTRAQ Quantitative Proteomics Free
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Sharon D'Souza; Andrea Petznick; Louis Tong; Reece C. Hall; Mohamad Rosman; Cordelia Chan; Siew Kwan Koh; Roger W. Beuerman; Lei Zhou; Jodhbir S. Mehta
Tags: keratomileusis, laser in situ, proteins, eye, proteomics
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3396-3402. doi:https://doi.org/10.1167/iovs.14-14113
Corneal Sensory Nerve Activity in an Experimental Model of UV Keratitis Free
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M. Carmen Acosta; Carolina Luna; Susana Quirce; Carlos Belmonte; Juana Gallar
Tags: cornea, inflammation, neurons, photokeratitis, ultraviolet rays
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3403-3412. doi:https://doi.org/10.1167/iovs.13-13774
Comparison of In Vivo Efficacy of Different Ocular Lubricants in Dry Eye Animal Models Free
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Xiaodong Zheng; Tomoko Goto; Yuichi Ohashi
Tags: animal model, dry eye syndromes, cornea, oryctolagus cuniculus
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3454-3460. doi:https://doi.org/10.1167/iovs.13-13730
Sleep Deprivation Reduces Tear Secretion and Impairs the Tear Film Free
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Young Bok Lee; Jae Woong Koh; Joon Young Hyon; Won Ryang Wee; Jin Joo Kim; Young Joo Shin
Tags: bodily secretions, sleep deprivation, tear film finding, osmolar concentration, intraocular pressure
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3525-3531. doi:https://doi.org/10.1167/iovs.14-13881
Synthetic Neurotensin Analogues Are Nontoxic Analgesics for the Rabbit Cornea Free
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Charles Kim; Denise Barbut; Murk H. Heinemann; Gavril Pasternak; Mark I. Rosenblatt
Tags: analgesics, cornea, neurotensin, oryctolagus cuniculus, tetracaine
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3586-3593. doi:https://doi.org/10.1167/iovs.13-13050
Diabetes Mellitus Leads to Accumulation of Dendritic Cells and Nerve Fiber Damage of the Subbasal Nerve Plexus in the Cornea Free
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Katja Leppin; Ann-Kathrin Behrendt; Maria Reichard; Oliver Stachs; Rudolf F. Guthoff; Simone Baltrusch; Johanna C. Eule; Brigitte Vollmar
Tags: cornea, diabetes mellitus, mice, nerve fibers, neurons
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3603-3615. doi:https://doi.org/10.1167/iovs.14-14307
Biomechanical Responses of Healthy and Keratoconic Corneas Measured Using a Noncontact Scheimpflug-Based Tonometer Free
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Noor Q. Ali; Dipika V. Patel; Charles N. J. McGhee
Tags: cornea, tonometers, intraocular pressure, biomechanics, eye
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3651-3659. doi:https://doi.org/10.1167/iovs.13-13715
A Novel Murine Model for Keratoprosthesis Free
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Alja Crnej; Masahiro Omoto; Thomas H. Dohlman; John M. Graney; Claes H. Dohlman; Brigita Drnovsek-Olup; Reza Dana
Tags: cornea, donors, eye, histology, implantation procedure
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3681-3685. doi:https://doi.org/10.1167/iovs.14-14058
Extracellular Matrix Alterations in Late-Onset Fuchs' Corneal Dystrophy Free
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Julia M. Weller; Matthias Zenkel; Ursula Schlötzer-Schrehardt; Bjoern O. Bachmann; Theofilos Tourtas; Friedrich E. Kruse
Tags: agrin, clusterin, collagen, cornea, extracellular matrix
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3700-3708. doi:https://doi.org/10.1167/iovs.14-14154
Serum-Induced Differentiation of Human Meibomian Gland Epithelial Cells Free
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David A. Sullivan; Yang Liu; Wendy R. Kam; Juan Ding; Karin M. Green; Scott A. Shaffer; Mark P. Hatton; Shaohui Liu
Tags: epithelial cells, lipids, meibomian gland
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3866-3877. doi:https://doi.org/10.1167/iovs.13-13407
Mild Decentration Measured by a Scheimpflug Camera and Its Impact on Visual Quality Following SMILE in the Early Learning Curve Free
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Meiyan Li; Jing Zhao; Huamao Miao; Yang Shen; Ling Sun; Mi Tian; Elizabeth Wadium; Xingtao Zhou
Tags: coma, eye, learning, postoperative care, preoperative care
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3886-3892. doi:https://doi.org/10.1167/iovs.13-13714
Higher-Order Aberrations of Anterior and Posterior Corneal Surfaces in Patients With Keratectasia After LASIK Free
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Naoyuki Maeda; Tomoya Nakagawa; Ryo Kosaki; Shizuka Koh; Makoto Saika; Takashi Fujikado; Kohji Nishida
Tags: coma, cornea, keratomileusis, laser in situ, eye, keratoconus
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3905-3911. doi:https://doi.org/10.1167/iovs.14-14391

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Latency of Multifocal Visual Evoked Potentials in Nonoptic Neuritis Eyes of Multiple Sclerosis Patients Associated With Optic Radiation Lesions Free
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Daniah Alshowaeir; Con Yiannikas; Raymond Garrick; John Parratt; Michael H. Barnett; Stuart L. Graham; Alexander Klistorner
Tags: evoked potentials, visual, eye, multiple sclerosis, neuritis, optic radiation
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3758-3764. doi:https://doi.org/10.1167/iovs.14-14571
Effects of Strabismic Amblyopia on Visuomotor Behavior:
Part II. Visually Guided Reaching Free
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Ewa Niechwiej-Szwedo; Herbert C. Goltz; Mano Chandrakumar; Agnes M. F. Wong
Tags: amblyopia, precision, strabismic amblyopia, strabismus, eye
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3857-3865. doi:https://doi.org/10.1167/iovs.14-14543
Individual Larvae of the Zebrafish Mutant belladonna Display Multiple Infantile Nystagmus-Like Waveforms that Are Influenced by Viewing Conditions Free
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Sabina P. Huber-Reggi; Kaspar P. Mueller; Dominik Straumann; Melody Ying-Yu Huang; Stephan C. F. Neuhauss
Tags: larva, pathologic nystagmus, waveforms, zebrafish, belladonna
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3971-3978. doi:https://doi.org/10.1167/iovs.13-13576

Genetics

FLT1 Genetic Variation Predisposes to Neovascular AMD in Ethnically Diverse Populations and Alters Systemic FLT1 Expression Free
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Leah A. Owen; Margaux A. Morrison; Jeeyun Ahn; Se Joon Woo; Hajime Sato; Rosann Robinson; Denise J. Morgan; Fani Zacharaki; Marina Simeonova; Hironori Uehara; Usha Chakravarthy; Ruth E. Hogg; Balamurali K. Ambati; Maria Kotoula; Wolfgang Baehr; Neena B. Haider; Giuliana Silvestri; Joan W. Miller; Evangelia E. Tsironi; Lindsay A. Farrer; Ivana K. Kim; Kyu Hyung Park; Margaret M. DeAngelis
Tags: cohort studies, exudative age-related macular degeneration, genetics, single nucleotide polymorphism, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3543-3554. doi:https://doi.org/10.1167/iovs.14-14047
Mutation Analysis of Seven Known Glaucoma-Associated Genes in Chinese Patients With Glaucoma Free
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Xiaobo Huang; Miaoling Li; Xiangming Guo; Shiqiang Li; Xueshan Xiao; Xiaoyun Jia; Xing Liu; Qingjiong Zhang
Tags: chinese (other dialects), chinese people, genes, glaucoma, mutation
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3594-3602. doi:https://doi.org/10.1167/iovs.14-13927
Extended Association Study of PLEKHA7 and COL11A1 With Primary Angle Closure Glaucoma in a Han Chinese Population Free
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Yuhong Chen; Xueli Chen; Li Wang; Guy Hughes; Shaohong Qian; Xinghuai Sun
Tags: angle closure glaucoma, chinese (other dialects), chinese people, single nucleotide polymorphism
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3797-3802. doi:https://doi.org/10.1167/iovs.14-14370
IMPG2-Associated Retinitis Pigmentosa Displays Relatively Early Macular Involvement Free
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Ramon A. C. van Huet; Rob W. J. Collin; Anna M. Siemiatkowska; Caroline C. W. Klaver; Carel B. Hoyng; Francesca Simonelli; Muhammad I. Khan; Raheel Qamar; Eyal Banin; Frans P. M. Cremers; Thomas Theelen; Anneke I. den Hollander; L. Ingeborgh van den Born; B. Jeroen Klevering
Tags: atrophy, mutation, retinitis pigmentosa, eye, visual acuity
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3939-3953. doi:https://doi.org/10.1167/iovs.14-14129

Glaucoma

Influence of Correction of Ocular Magnification on Spectral-Domain OCT Retinal Nerve Fiber Layer Measurement Variability and Performance Free
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Sara Nowroozizadeh; Nila Cirineo; Navid Amini; Shane Knipping; Ted Chang; Tom Chou; Joseph Caprioli; Kouros Nouri-Mahdavi
Tags: magnification, retinal nerve fiber layer, glaucoma, eye
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3439-3446. doi:https://doi.org/10.1167/iovs.14-13880
An Investigation of Lateral Geniculate Nucleus Volume in Patients With Primary Open-Angle Glaucoma Using 7 Tesla Magnetic Resonance Imaging Free
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Jong Yeon Lee; Hye Jin Jeong; Jong Hwan Lee; Yu Jeong Kim; Eung Yeop Kim; Yong Yeon Kim; Taekhyun Ryu; Zang-Hee Cho; Young-Bo Kim
Tags: glaucoma, lateral geniculate body, magnetic resonance imaging, open-angle glaucoma, volume
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3468-3476. doi:https://doi.org/10.1167/iovs.14-13902
A Comparative Effectiveness Analysis of Visual Field Outcomes After Projected Glaucoma Screening Using SD-OCT in African American Communities Free
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Dana M. Blumberg; Reena Vaswani; Eva Nong; Lama Al-Aswad; George A. Cioffi
Tags: african american, blindness, community, glaucoma, glaucoma screening
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3491-3500. doi:https://doi.org/10.1167/iovs.14-14014
Topographic Localization of Macular Retinal Ganglion Cell Loss Associated With Localized Peripapillary Retinal Nerve Fiber Layer Defect Free
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Ko Eun Kim; Ki Ho Park; Beong Wook Yoo; Jin Wook Jeoung; Dong Myung Kim; Hee Chan Kim
Tags: retinal ganglion cells, retinal nerve fiber layer, ganglia
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3501-3508. doi:https://doi.org/10.1167/iovs.14-13925
Longitudinal Alterations in the Dynamic Autoregulation of Optic Nerve Head Blood Flow Revealed in Experimental Glaucoma Free
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Lin Wang; Grant Cull; Claude F. Burgoyne; Simon Thompson; Brad Fortune
Tags: glaucoma, homeostasis, intraocular pressure, keratosis follicularis, optic disk
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3509-3516. doi:https://doi.org/10.1167/iovs.14-14020
Comparison of Anterior Segment Parameters Between the Acute Primary Angle Closure Eye and the Fellow Eye Free
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Jong Rak Lee; Kyung Rim Sung; Seungbong Han
Tags: eye
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3646-3650. doi:https://doi.org/10.1167/iovs.13-13009
Noninvasive Measurement of Scleral Stiffness and Tangent Modulus in Porcine Eyes Free
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Leo K. K. Leung; Match W. L. Ko; Cong Ye; David C. C. Lam; Christopher K. S. Leung
Tags: eye, sclera, suidae, intraocular pressure
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3721-3726. doi:https://doi.org/10.1167/iovs.13-13674
The Structure of the Trabecular Meshwork, Its Connections to the Ciliary Muscle, and the Effect of Pilocarpine on Outflow Facility in Mice Free
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Darryl R. Overby; Jacques Bertrand; Martin Schicht; Friedrich Paulsen; W. Daniel Stamer; Elke Lütjen-Drecoll
Tags: ciliary muscle, mice, nerve supply, pilocarpine, trabecular meshwork
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3727-3736. doi:https://doi.org/10.1167/iovs.13-13699
Pilocarpine-Induced Dilation of Schlemm's Canal and Prevention of Lumen Collapse at Elevated Intraocular Pressures in Living Mice Visualized by OCT Free
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Guorong Li; Sina Farsiu; Stephanie J. Chiu; Pedro Gonzalez; Elke Lütjen-Drecoll; Darryl R. Overby; W. Daniel Stamer
Tags: intraocular pressure, mice, pilocarpine, schlemm's canal, dilatation, pathologic
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3737-3746. doi:https://doi.org/10.1167/iovs.13-13700
Monitoring Retinal Morphologic and Functional Changes in Mice Following Optic Nerve Crush Free
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Yang Liu; Colleen M. McDowell; Zhang Zhang; Holly E. Tebow; Robert J. Wordinger; Abbot F. Clark
Tags: mice, optic nerve, cell count, electroretinography, retina
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3766-3774. doi:https://doi.org/10.1167/iovs.14-13895
Expression of the Primary Angle Closure Glaucoma (PACG) Susceptibility Gene PLEKHA7 in Endothelial and Epithelial Cell Junctions in the Eye Free
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Mei Chin Lee; Anita S. Y. Chan; Shuang Ru Goh; Maryam Hazly Hilmy; Monisha E. Nongpiur; Wanjin Hong; Tin Aung; Walter Hunziker; Eranga N. Vithana
Tags: angle closure glaucoma, body tissue, disease susceptibility, endothelium, epithelial cells
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3833-3841. doi:https://doi.org/10.1167/iovs.14-14145

Immunology and Microbiology

Correlation Between Disease Severity and Presence of Ocular Autoantibodies in Juvenile Idiopathic Arthritis-Associated Uveitis Free
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Karoline Walscheid; Maren Hennig; Carsten Heinz; Susanne Wasmuth; Martin Busch; Dirk Bauer; Martha Dietzel; Cornelia A. Deeg; Arnd Heiligenhaus
Tags: arthritis, autoantibodies, child, uveitis, antibodies
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3447-3453. doi:https://doi.org/10.1167/iovs.13-13444
The Ocular Endothelin System: A Novel Target for the Treatment of Endotoxin-Induced Uveitis With Bosentan Free
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Sadullah Keles; Zekai Halici; Hasan Tarik Atmaca; Muhammed Yayla; Kenan Yildirim; Metin Ekinci; Erol Akpinar; Durdu Altuner; Ozgur Cakici; Zafer Bayraktutan
Tags: bosentan, endothelins, endotoxins, uveitis, endothelin receptor antagonists
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3517-3524. doi:https://doi.org/10.1167/iovs.14-14193
Protease-Activated Receptor 2 (PAR2) Is Upregulated by Acanthamoeba Plasminogen Activator (aPA) and Induces Proinflammatory Cytokine in Human Corneal Epithelial Cells Free
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Trivendra Tripathi; Mahshid Abdi; Hassan Alizadeh
Tags: acanthamoeba, american psychiatric association, antiphospholipid antibodies measurement, corneal epithelial cells, cytokine
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3912-3921. doi:https://doi.org/10.1167/iovs.14-14486

Lens

Association Between Dietary Carbohydrate Intake and Dietary Glycemic Index and Risk of Age-Related Cataract: A Meta-Analysis Free
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Han Wu; Huina Zhang; Peiwei Li; Tao Gao; Jijian Lin; Jun Yang; Yihua Wu; Juan Ye
Tags: carbohydrates, cataract, senile, diet, dietary carbohydrates, glycemic index
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3660-3668. doi:https://doi.org/10.1167/iovs.13-13695

Low Vision

Eye Movements and Reading Speed in Macular Disease: The Shrinking Perceptual Span Hypothesis Requires and Is Supported by a Mediation Analysis Free
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Aurélie Calabrèse; Jean-Baptiste Bernard; Géraldine Faure; Louis Hoffart; Eric Castet
Tags: age-related macular degeneration, eye movement, reading speed, reading (activity)
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3638-3645. doi:https://doi.org/10.1167/iovs.13-13408

Multidisciplinary Ophthalmic Imaging

Macular Choroidal Thickness Profile in a Healthy Population Measured by Swept-Source Optical Coherence Tomography Free
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Jorge Ruiz-Medrano; Ignacio Flores-Moreno; Pablo Peña-García; Javier A. Montero; Jay S. Duker; José M. Ruiz-Moreno
Tags: choroid, eye, optical coherence tomography, significance
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3532-3542. doi:https://doi.org/10.1167/iovs.14-13868
In Vivo Assessment of Aqueous Humor Dynamics Upon Chronic Ocular Hypertension and Hypotensive Drug Treatment Using Gadolinium-Enhanced MRI Free
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Leon C. Ho; Ian P. Conner; Chi-Wai Do; Seong-Gi Kim; Ed X. Wu; Gadi Wollstein; Joel S. Schuman; Kevin C. Chan
Tags: aqueous humor, eye, gadolinium, intraocular pressure, magnetic resonance imaging
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3747-3757. doi:https://doi.org/10.1167/iovs.14-14263
Angiographic Features of Transgenic Mice With Increased Expression of Human Serine Protease HTRA1 in Retinal Pigment Epithelium Free
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Sandeep Kumar; Zachary Berriochoa; Balamurali K Ambati; Yingbin Fu
Tags: angiogram, htra1 gene, mice, mice, transgenic, ophthalmoscopy
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3842-3850. doi:https://doi.org/10.1167/iovs.13-13111
Choroidal Structure in Normal Eyes and After Photodynamic Therapy Determined by Binarization of Optical Coherence Tomographic Images Free
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Shozo Sonoda; Taiji Sakamoto; Takehiro Yamashita; Makoto Shirasawa; Eisuke Uchino; Hiroto Terasaki; Masatoshi Tomita
Tags: choroid, eye, optical coherence tomography, photochemotherapy
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3893-3899. doi:https://doi.org/10.1167/iovs.14-14447
Reproducibility of Anterior Chamber Angle Analyses With the Swept-Source Optical Coherence Tomography in Young, Healthy Caucasians Free
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Hellen C. S. Römkens; Henny J. M. Beckers; Marc Frusch; Tos T. J. M. Berendschot; John de Brabander; Carroll A. B. Webers
Tags: anterior chamber of eye, european continental ancestry group, optical coherence tomography, nose
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3999-4004. doi:https://doi.org/10.1167/iovs.13-12904

Retina

Comparison of Conventional Pattern and Novel Navigated Panretinal Photocoagulation in Proliferative Diabetic Retinopathy Free
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Jay Chhablani; Annie Mathai; Padmaja Rani; Vishali Gupta; J. Fernando Arevalo; Igor Kozak
Tags: lasers, panretinal photocoagulation, proliferative diabetic retinopathy, burns, exanthema
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3432-3438. doi:https://doi.org/10.1167/iovs.14-13936
Analysis of the Intraocular Jet Flows and Pressure Gradients Induced by Air and Fluid Infusion: Mechanism of Focal Chorioretinal Damage Free
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Yong Joon Kim; Sungkil Jo; Daruchi Moon; Youngcheol Joo; Kyung Seek Choi
Tags: fluid flow, infusion procedures, retina, eye
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3477-3483. doi:https://doi.org/10.1167/iovs.14-14248
Wide-Field Fundus Autofluorescence Abnormalities and Visual Function in Patients With Cone and Cone-Rod Dystrophies Free
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Maho Oishi; Akio Oishi; Ken Ogino; Yukiko Makiyama; Norimoto Gotoh; Masafumi Kurimoto; Nagahisa Yoshimura
Tags: electroretinography, fundus autofluorescence imaging, progressive cone-rod dystrophy, retinal cone, vision
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3572-3577. doi:https://doi.org/10.1167/iovs.14-13912
Retinal Microglia Are Activated by Systemic Fungal Infection Free
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Victoria Maneu; Agustina Noailles; Javier Megías; Violeta Gómez-Vicente; Núria Carpena; M. Luisa Gil; Daniel Gozalbo; Nicolás Cuenca
Tags: mice, microglia, systemic mycosis, retina
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3578-3585. doi:https://doi.org/10.1167/iovs.14-14051
Delayed Administration of Bone Marrow Mesenchymal Stem Cell Conditioned Medium Significantly Improves Outcome After Retinal Ischemia in Rats Free
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John C. Dreixler; Jacqueline N. Poston; Irina Balyasnikova; Afzhal R. Shaikh; Kelsey Y. Tupper; Sineadh Conway; Venkat Boddapati; Marcus M. Marcet; Maciej S. Lesniak; Steven Roth
Tags: bone marrow, conditioning (psychology), culture media, conditioned, ischemia, proteins
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3785-3796. doi:https://doi.org/10.1167/iovs.13-11683
Angiotensin-Converting Enzyme 2 (ACE2) Activator Diminazene Aceturate Ameliorates Endotoxin-Induced Uveitis in Mice Free
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Yiguo Qiu; Pollob Kumar Shil; Ping Zhu; Hongxia Yang; Amrisha Verma; Bo Lei; Qiuhong Li
Tags: angiotensin-converting enzyme, cytokine, diminazene, endotoxins, inflammation
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3809-3818. doi:https://doi.org/10.1167/iovs.14-13883
PPARα Regulates Mobilization and Homing of Endothelial Progenitor Cells Through the HIF-1α/SDF-1 Pathway Free
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Zhongxiao Wang; Elizabeth Moran; Lexi Ding; Rui Cheng; Xun Xu; Jian-xing Ma
Tags: hypoxia, mice, stromal cell-derived factor 1, endothelial progenitor cells, retina
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3820-3832. doi:https://doi.org/10.1167/iovs.13-13396
Role of Soluble Vascular Endothelial Growth Factor Receptors-1 and -2, Their Ligands, and Other Factors in Branch Retinal Vein Occlusion With Macular Edema Free
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Hidetaka Noma; Tatsuya Mimura; Kanako Yasuda; Masahiko Shimura
Tags: edema, ligands, vascular endothelial growth factor a, venous retinal branch occlusion, cytokine
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3878-3885. doi:https://doi.org/10.1167/iovs.14-13961
Relative Flow Volume, a Novel Blood Flow Index in the Human Retina Derived From Laser Speckle Flowgraphy Free
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Yukihiro Shiga; Toshifumi Asano; Hiroshi Kunikata; Fumihiko Nitta; Hajime Sato; Toru Nakazawa; Masahiko Shimura
Tags: fluid flow, lasers, retina, vascular flow, volume
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3899-3904. doi:https://doi.org/10.1167/iovs.14-14116
Long-Term Reduction in Infrared Autofluorescence Caused by Infrared Light Below the Maximum Permissible Exposure Free
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Benjamin D. Masella; David R. Williams; William S. Fischer; Ethan A. Rossi; Jennifer J. Hunter
Tags: autofluorescence, diagnostic imaging, infrared lamp, infrared rays, light
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3929-3938. doi:https://doi.org/10.1167/iovs.13-12562

Retinal Cell Biology

Sigma Receptor Ligand, (+)-Pentazocine, Suppresses Inflammatory Responses of Retinal Microglia Free
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Jing Zhao; Yonju Ha; Gregory I. Liou; Graydon B. Gonsalvez; Sylvia B. Smith; Kathryn E. Bollinger
Tags: inflammatory response, ligands, microglia, pentazocine, receptors, sigma
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3375-3384. doi:https://doi.org/10.1167/iovs.13-12823
Transactivation of EGF Receptors in Chicken Müller Cells by α2A-Adrenergic Receptors Stimulated by Brimonidine Free
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Mohammad Harun-Or-Rashid; Niclas Lindqvist; Finn Hallböök
Tags: brimonidine, cardiac support procedures, chickens, epidermal growth factor receptors, mast-cell sarcoma
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3385-3394. doi:https://doi.org/10.1167/iovs.13-13823
Deletion of Hemojuvelin, an Iron-Regulatory Protein, in Mice Results in Abnormal Angiogenesis and Vasculogenesis in Retina Along With Reactive Gliosis Free
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Amany Tawfik; Jaya P. Gnana-Prakasam; Sylvia B. Smith; Vadivel Ganapathy
Tags: angiogenesis, gliosis, hfe2 gene, iron, mice
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3616-3625. doi:https://doi.org/10.1167/iovs.13-13677
Mutant ELOVL4 That Causes Autosomal Dominant Stargardt-3 Macular Dystrophy Is Misrouted to Rod Outer Segment Disks Free
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Martin-Paul Agbaga; Beatrice M. Tam; Jenny S. Wong; Lee Ling Yang; Robert E. Anderson; Orson L. Moritz
Tags: animals, transgenic, macular dystrophy, photoreceptors, proteins, retinal degeneration
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3669-3680. doi:https://doi.org/10.1167/iovs.13-13099
The Vasoneuronal Effects of AT1 Receptor Blockade in a Rat Model of Retinopathy of Prematurity Free
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Kate M. Hatzopoulos; Kirstan A. Vessey; Jennifer L. Wilkinson-Berka; Erica L. Fletcher
Tags: oxygen, retinal diseases, valsartan, rod photoreceptors, retinopathy of prematurity
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3957-3970. doi:https://doi.org/10.1167/iovs.13-13532

Translational

Spontaneous CNV in a Novel Mutant Mouse Is Associated With Early VEGF-A–Driven Angiogenesis and Late-Stage Focal Edema, Neural Cell Loss, and Dysfunction Free
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Norihiro Nagai; Pete Lundh von Leithner; Kanako Izumi-Nagai; Brett Hosking; Bo Chang; Ron Hurd; Peter Adamson; Anthony P. Adamis; Richard H. Foxton; Yin Shan Ng; David T. Shima
Tags: choroidal neovascularization, edema, mice, pathophysiology, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3709-3719. doi:https://doi.org/10.1167/iovs.14-13989

Visual Psychophysics and Physiological Optics

Assessment of Macular Function Using the SKILL Card in Adults With Type 2 Diabetes Mellitus Free
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Kavita P. Dhamdhere; Marilyn E. Schneck; Marcus A. Bearse, Jr,; Wendy Lam; Shirin Barez; Anthony J. Adams
Tags: adult, diabetes mellitus, type 2, macular function, nonproliferative diabetic retinopathy, vision
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3368-3374. doi:https://doi.org/10.1167/iovs.13-13368
MMP-2, MMP-3, TIMP-1, TIMP-2, and TIMP-3 Protein Levels in Human Aqueous Humor: Relationship With Axial Length Free
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Yan Jia; Dan-Ning Hu; Dongqing Zhu; Leilei Zhang; Ping Gu; Xianqun Fan; Jibo Zhou
Tags: aqueous humor, gelatinase a, matrix metalloproteinases, stromelysin 1, timp2 protein, human
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3922-3928. doi:https://doi.org/10.1167/iovs.14-13983

Clinical Trials

Effect of Intravitreal Triamcinolone Acetonide or Bevacizumab on Choroidal Thickness in Eyes With Diabetic Macular Edema Free
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Shozo Sonoda; Taiji Sakamoto; Takehiro Yamashita; Hiroki Otsuka; Makoto Shirasawa; Naoko Kakiuchi; Eisuke Uchino; Hiroto Terasaki; Hiroki Kawano
Tags: bevacizumab, choroid, diabetic macular edema, eye, steroids
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3979-3985. doi:https://doi.org/10.1167/iovs.14-14188

Letters to the Editor

Aspirin Use and Risk of Age-Related Macular Degeneration Free
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Wei Wang; Xiulan Zhang
Tags: age-related macular degeneration, aspirin
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3954. doi:https://doi.org/10.1167/iovs.14-14203
Author Response: Aspirin Use and Risk of Age-Related Macular Degeneration Free
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Juan Ye; Yu-Feng Xu
Tags: age-related macular degeneration, aspirin
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3955-3956. doi:https://doi.org/10.1167/iovs.14-14322
Patterns of Macular Ganglion Cell Abnormalities in Various Ocular Conditions Free
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Young Hoon Hwang
Tags: ganglia
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3995-3996. doi:https://doi.org/10.1167/iovs.14-14438
Author Response: Patterns of Macular Ganglion Cell Abnormalities in Various Ocular Conditions Free
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Jin Wook Jeoung; Yong Woo Kim; Ki Ho Park
Tags: ganglia
Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3997. doi:https://doi.org/10.1167/iovs.14-14713

Erratum

Erratum Free
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Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3395. doi:https://doi.org/10.1167/iovs.13-12380a
Erratum Free
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Investigative Ophthalmology & Visual Science June 2014, Vol.55, 3998. doi:https://doi.org/10.1167/iovs.12-10714a
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