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Research Highlight

Prevention of Posterior Capsule Opacification by an Intracapsular Open Capsule Device Free
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Nino Hirnschall
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4014. doi:https://doi.org/10.1167/iovs.14-14839
Imaging Cone Photoreceptor Inner Segments in the Living Human Eye Free
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Ronald M. Hansen
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4252. doi:https://doi.org/10.1167/iovs.14-14967
Experimental Evidence of Fluid Secretion of Rabbit Lacrimal Gland Duct Epithelium Free
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Chuanqing Ding
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4368. doi:https://doi.org/10.1167/iovs.14-15002

Anatomy and Pathology/Oncology

Identification of Circulating Melanoma Cells in Uveal Melanoma Patients by Dual-Marker Immunoenrichment Free
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AysegĂĽl Tura; Julia LĂĽke; Hartmut Merz; Mihaela Reinsberg; Matthias LĂĽke; Martine J. Jager; Salvatore Grisanti
Tags: melanoma, screening, uveal melanoma, tumor cells
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4395-4404. doi:https://doi.org/10.1167/iovs.14-14512
Morphological Alterations Within the Peripheral Fixation of the Iris Dilator Muscle in Eyes With Pigmentary Glaucoma Free
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Cassandra M. FlĂĽgel-Koch; Ozan Y. Tektas; Paul L. Kaufman; Friedrich P. Paulsen; Elke LĂĽtjen-Drecoll
Tags: dilators, eye, muscle, glaucoma, pigmentary, iris fixation
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4541-4551. doi:https://doi.org/10.1167/iovs.13-13765

Biochemistry and Molecular Biology

Surface Properties of Artificial Tear Film Lipid Layers: Effects of Wax Esters Free
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Pipsa Kulovesi; Antti H. Rantamäki; Juha M. Holopainen
Tags: esters, lipids, tear film finding, evaporation, surface properties
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4448-4454. doi:https://doi.org/10.1167/iovs.14-14122
Mitochondrial Oxidative Stress in the Retinal Pigment Epithelium Leads to Localized Retinal Degeneration Free
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Haoyu Mao; Soo Jung Seo; Manas R. Biswal; Hong Li; Mandy Conners; Arathi Nandyala; Kyle Jones; Yun-Zheng Le; Alfred S. Lewin
Tags: atrophy, mice, oxidative stress, retinal degeneration, mitochondria
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4613-4627. doi:https://doi.org/10.1167/iovs.14-14633
Fullerenol Protects Retinal Pigment Epithelial Cells From Oxidative Stress–Induced Premature Senescence via Activating SIRT1 Free
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Chun-Chun Zhuge; Jing-Ying Xu; Jingfa Zhang; Weiye Li; Peng Li; Zongyi Li; Ling Chen; Xiaoqing Liu; Peng Shang; Hua Xu; Yanjun Lu; Fang Wang; Lixia Lu; Guo-Tong Xu
Tags: aging, older adult, oxidative stress, retinal pigment cell, dna damage
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4628-4638. doi:https://doi.org/10.1167/iovs.13-13732

Clinical and Epidemiologic Research

Malnutrition and Retinal Vascular Caliber in the Elderly: The POLA Study Free
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Vincent Daien; Isabelle Carriere; Ryo Kawasaki; Jean-Paul Cristol; Max Villain; Pierre Fesler; Karen Ritchie; Cecile Delcourt; for the POLA Study Group
Tags: malnutrition, older adult, retinal vascular caliber, body mass index procedure, prealbumin
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4042-4049. doi:https://doi.org/10.1167/iovs.13-13721
Geospatial Distribution and Clustering of Chlamydia trachomatis in Communities Undergoing Mass Azithromycin Treatment Free
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Jithin Yohannan; Bing He; Jiangxia Wang; Gregory Greene; Yvette Schein; Harran Mkocha; Beatriz Munoz; Thomas C. Quinn; Charlotte Gaydos; Sheila K. West
Tags: azithromycin, child, chlamydia trachomatis, community, infections
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4144-4150. doi:https://doi.org/10.1167/iovs.14-14148
Estimating Minimally Important Differences for Two Vision-Specific Quality of Life Measures Free
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Brenda W. Gillespie; David C. Musch; Leslie M. Niziol; Nancy K. Janz
Tags: follow-up, quality of life, vision, questionnaires, eye
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4206-4212. doi:https://doi.org/10.1167/iovs.13-13683
Ethnic Variation in Early Age-Related Macular Degeneration Lesions Between White Australians and Singaporean Asians Free
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Nichole Joachim; Paul Mitchell; Christine Younan; George Burlutsky; Ching-Yu Cheng; Chui Ming Gemmy Cheung; Yingfeng Zheng; Mireille Moffitt; Tien Yin Wong; Jie Jin Wang
Tags: age-related macular degeneration, asian, drusen, ethnic group, prevalence
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4421-4429. doi:https://doi.org/10.1167/iovs.14-14476
Epidemiological Association Between Systemic Diseases and Age-Related Macular Degeneration: The Korea National Health and Nutrition Examination Survey 2008–2011 Free
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Bum-Joo Cho; Jang Won Heo; Jae Pil Shin; Jeeyun Ahn; Tae Wan Kim; Hum Chung
Tags: age-related macular degeneration, korea, national health and nutrition examination survey, smoking, liver cancer
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4430-4437. doi:https://doi.org/10.1167/iovs.14-14379
The Computer-Vision Symptom Scale (CVSS17): Development and Initial Validation Free
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Mariano González-Pérez; Rosario Susi; Beatriz Antona; Ana Barrio; Enrique González
Tags: computers, questionnaires, signs and symptoms, vision, reliability
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4504-4511. doi:https://doi.org/10.1167/iovs.13-13818
Myopia Is Associated With Lower Vitamin D Status in Young Adults Free
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Seyhan Yazar; Alex W. Hewitt; Lucinda J. Black; Charlotte M. McKnight; Jenny A. Mountain; Justin C. Sherwin; Wendy H. Oddy; Minas T. Coroneo; Robyn M. Lucas; David A. Mackey
Tags: myopia, vitamin d, young adult, mass or substance concentration per volume
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4552-4559. doi:https://doi.org/10.1167/iovs.14-14589

Cornea

Vimentin Knockdown Decreases Corneal Opacity Free
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Subrata K. Das; Isha Gupta; Yang Kyung Cho; Xiaohui Zhang; Hironori Uehara; Santosh Kumar Muddana; Ashlie A. Bernhisel; Bonnie Archer; Balamurali K. Ambati
Tags: cornea, corneal opacity, mice, plasmids, vimentin
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4030-4040. doi:https://doi.org/10.1167/iovs.13-13494
Generation of a Biomimetic Human Artificial Cornea Model Using Wharton's Jelly Mesenchymal Stem Cells Free
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Ingrid Garzón; Miguel Angel Martín-Piedra; Camilo Alfonso-Rodríguez; Miguel González-Andrades; Victor Carriel; Carlos Martínez-Gómez; Antonio Campos; Miguel Alaminos
Tags: cornea, wharton's jelly, mesenchymal stem cells, epithelium, biomimetics
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4073-4083. doi:https://doi.org/10.1167/iovs.14-14304
Blue Light–Induced Oxidative Stress in Human Corneal Epithelial Cells: Protective Effects of Ethanol Extracts of Various Medicinal Plant Mixtures Free
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Jee-Bum Lee; Soo-Hyun Kim; Seung-Chul Lee; Hee-Gu Kim; Ho-Geun Ahn; Zhengri Li; Kyung Chul Yoon
Tags: antioxidants, blue light, corneal epithelial cells, ethanol, oxidative stress
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4119-4127. doi:https://doi.org/10.1167/iovs.13-13441
A New, Specular Reflection-Based, Precorneal Tear Film Stability Measurement Technique in a Rabbit Model: Viscoelastic Increases Tear Film Stability Free
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Derek Nankivil; Alex Gonzalez; Esdras Arrieta; Cornelis Rowaan; Mariela C. Aguilar; Krystal Sotolongo; Florence A. Cabot; Sonia H. Yoo; Jean-Marie A. Parel
Tags: oryctolagus cuniculus, tear film finding, cornea, evaporation
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4158-4163. doi:https://doi.org/10.1167/iovs.14-14157
NF-ÎşB Mediates the Survival of Corneal Myofibroblast Induced by Angiotensin II Free
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Hong-Wei Pan; Yu-Hong Cui; Jun-Wen Zeng
Tags: angiotensin ii, cornea, myofibroblasts
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4220-4228. doi:https://doi.org/10.1167/iovs.13-13735
Multipurpose Care Solution–Induced Corneal Surface Disruption and Pseudomonas aeruginosa Internalization in the Rabbit Corneal Epithelium Free
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Leila C. Posch; Meifang Zhu; Danielle M. Robertson
Tags: cornea, corneal epithelium, epithelium, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4229-4237. doi:https://doi.org/10.1167/iovs.14-14513
Intrastromal Application of Riboflavin for Corneal Crosslinking Free
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Theo G. Seiler; Isaak Fischinger; Tim Senfft; Gerald Schmidinger; Theo Seiler
Tags: corneal collagen cross-linking, riboflavin, stress, ultraviolet a radiation, cornea
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4261-4265. doi:https://doi.org/10.1167/iovs.14-14021
Aerobic Exercise Increases Tear Secretion in Type 2 Diabetic Mice Free
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Kokoro Sano; Motoko Kawashima; Akiko Ito; Takaaki Inaba; Kohkichi Morimoto; Mitsuhiro Watanabe; Kazuo Tsubota
Tags: aica ribonucleotide, bodily secretions, diabetes mellitus, exercise, mice
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4287-4294. doi:https://doi.org/10.1167/iovs.13-13289
Angiopoietin-1 Is Regulated by miR-204 and Contributes to Corneal Neovascularization in KLEIP-Deficient Mice Free
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Jakob N. Kather; Julian Friedrich; Nicole Woik; Carsten Sticht; Norbert Gretz; Hans-Peter Hammes; Jens Kroll
Tags: angiopoietins, corneal neovascularization, mice, vascular endothelial growth factor a, cornea
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4295-4303. doi:https://doi.org/10.1167/iovs.13-13619
Biomechanical Characterization of Keratoconus Corneas Ex Vivo With Brillouin Microscopy Free
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Giuliano Scarcelli; Sebastien Besner; Roberto Pineda; Seok Hyun Yun
Tags: cornea, keratoconus
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4490-4495. doi:https://doi.org/10.1167/iovs.14-14450
Mitochondrial Polymorphism A10398G and Haplogroup I Are Associated With Fuchs' Endothelial Corneal Dystrophy Free
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Yi-Ju Li; Mollie A. Minear; Xuejun Qin; Jacqueline Rimmler; Michael A. Hauser; R. Rand Allingham; Robert P. Igo; Jonathan H. Lass; Sudha K. Iyengar; Gordon K. Klintworth; Natalie A. Afshari; Simon G. Gregory
Tags: dna, mitochondrial, endothelium, hereditary corneal dystrophy, mitochondria, polymorphism
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4577-4584. doi:https://doi.org/10.1167/iovs.13-13517
First Demonstration of Ocular Refractive Change Using Blue-IRIS in Live Cats Free
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Daniel E. Savage; Daniel R. Brooks; Margaret DeMagistris; Lisen Xu; Scott MacRae; Jonathan D. Ellis; Wayne H. Knox; Krystel R. Huxlin
Tags: adaptive testing, cats, cornea, eye, chloramphenicol o-acetyltransferase
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4603-4612. doi:https://doi.org/10.1167/iovs.14-14373

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Time Course of Dichoptic Masking in Normals and Suppression in Amblyopes Free
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Jiawei Zhou; Suzanne McNeill; Raiju J. Babu; Daniel H. Baker; William R. Bobier; Robert F. Hess
Tags: perceptual masking, time factors, noise, eye, luminance
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4098-4104. doi:https://doi.org/10.1167/iovs.14-13969
RNA Expression Analysis of Passive Transfer Myasthenia Supports Extraocular Muscle as a Unique Immunological Environment Free
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Yuefang Zhou; Henry J. Kaminski; Bendi Gong; Georgiana Cheng; Jason M. Feuerman; Linda Kusner
Tags: antibodies, genes, muscle, muscle of orbit, myasthenias
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4348-4359. doi:https://doi.org/10.1167/iovs.14-14422
The Detection of Macular Analysis by SD-OCT for Optic Chiasmal Compression Neuropathy and Nasotemporal Overlap Free
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Azusa Akashi; Akiyasu Kanamori; Kaori Ueda; Yoshiko Matsumoto; Yuko Yamada; Makoto Nakamura
Tags: compression neuropathy, eye, optics, nose
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4667-4672. doi:https://doi.org/10.1167/iovs.14-14766

Genetics

Rare Complement Factor H Variant Associated With Age-Related Macular Degeneration in the Amish Free
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Joshua D. Hoffman; Jessica N. CookeBailey; Laura D'Aoust; William Cade; Juan Ayala-Haedo; Denise Fuzzell; Renee Laux; Larry D. Adams; Lori Reinhart-Mercer; Laura Caywood; Patrice Whitehead-Gay; Anita Agarwal; Gaofeng Wang; William K. Scott; Margaret A. Pericak-Vance; Jonathan L. Haines
Tags: age-related macular degeneration, complement factor h, self-report, whole exome sequencing, genetic linkage analysis
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4455-4460. doi:https://doi.org/10.1167/iovs.13-13684

Glaucoma

TGF-β2–Mediated Ocular Hypertension Is Attenuated in SPARC-Null Mice Free
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Swarup S. Swaminathan; Dong-Jin Oh; Min Hyung Kang; Allan R. Shepard; Iok-Hou Pang; Douglas J. Rhee
Tags: attenuation, intraocular pressure, mice, ocular hypertension, sparc study
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4084-4097. doi:https://doi.org/10.1167/iovs.13-12463
Intraocular Pressure, Blood Pressure, and Retinal Blood Flow Autoregulation: A Mathematical Model to Clarify Their Relationship and Clinical Relevance Free
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Giovanna Guidoboni; Alon Harris; Simone Cassani; Julia Arciero; Brent Siesky; Annahita Amireskandari; Leslie Tobe; Patrick Egan; Ingrida Januleviciene; Joshua Park
Tags: hemodynamics, intraocular pressure, vascular flow, mathematical model, blood pressure
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4105-4118. doi:https://doi.org/10.1167/iovs.13-13611
Intraocular Pressure and Associated Factors in Children: The Shandong Children Eye Study Free
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Wen Jun Jiang; Jian Feng Wu; Yuan Yuan Hu; Hui Wu; Wei Sun; Tai Liang Lu; Xing Rong Wang; Hong Sheng Bi; Jost B. Jonas
Tags: child, eye, intraocular pressure, myopia, body mass index procedure
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4128-4134. doi:https://doi.org/10.1167/iovs.14-14244
Rates of Glaucomatous Visual Field Change in a Large Clinical Population Free
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Balwantray C. Chauhan; Rizwan Malik; Lesya M. Shuba; Paul E. Rafuse; Marcelo T. Nicolela; Paul H. Artes
Tags: follow-up, glaucoma, intraocular pressure, visual fields
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4135-4143. doi:https://doi.org/10.1167/iovs.14-14643
Inhibition by All-Trans-Retinoic Acid of Transforming Growth Factor-β–Induced Collagen Gel Contraction Mediated by Human Tenon Fibroblasts Free
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Yang Liu; Kazuhiro Kimura; Tomoko Orita; Shinichiro Teranishi; Katsuyoshi Suzuki; Koh-Hei Sonoda
Tags: collagen, gel, tretinoin, fibroblasts
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4199-4205. doi:https://doi.org/10.1167/iovs.13-13572
Association of LOXL1 Polymorphisms With Pseudoexfoliation, Glaucoma, Intraocular Pressure, and Systemic Diseases in a Greek Population. The Thessaloniki Eye Study Free
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Eleftherios Anastasopoulos; Anne L. Coleman; M. Roy Wilson; Janet S. Sinsheimer; Fei Yu; Sokratis Katafigiotis; Panayiota Founti; Angeliki Salonikiou; Theofanis Pappas; Archimidis Koskosas; Theodora Katopodi; Alexandros Lambropoulos; Fotis Topouzis
Tags: exfoliation syndrome, eye, greek, intraocular pressure, open-angle glaucoma
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4238-4243. doi:https://doi.org/10.1167/iovs.14-13991
Optic Nerve Head and Peripapillary Morphometrics in Myopic Glaucoma Free
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Sieun Lee; Sherry X. Han; Mei Young; Mirza Faisal Beg; Marinko V. Sarunic; Paul J. Mackenzie
Tags: bruch's basal membrane, glaucoma, optic disk, eye
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4378-4393. doi:https://doi.org/10.1167/iovs.14-14227
Quantitative Analysis of Iris Changes After Physiologic and Pharmacologic Mydriasis in a Rural Chinese Population Free
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Ye Zhang; Si Zhen Li; Lei Li; Ming Guang He; Ravi Thomas; Ning Li Wang
Tags: chinese (other dialects), chinese people, eye, immune reconstitution inflammatory syndrome, iris
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4405-4412. doi:https://doi.org/10.1167/iovs.13-13782
Reducing Variability in Visual Field Assessment for Glaucoma Through Filtering That Combines Structural and Functional Information Free
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Lisha Deng; Shaban Demirel; Stuart K. Gardiner
Tags: filters, glaucoma, visual fields
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4593-4602. doi:https://doi.org/10.1167/iovs.13-13813
Subconjunctival Versus Intrascleral Application of Mitomycin C During Trabeculectomy Free
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Miaomiao Zhang; Bin Li; Wei Liu; Jianrong Wang; Xinyi Wu
Tags: blister, mitomycin, postoperative care, surgical procedures, operative, trabeculectomy
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4639-4644. doi:https://doi.org/10.1167/iovs.14-14159
Longitudinal Study of Iris Concavity, Corneal Biomechanics, and Correlations to Ocular Biometry in a Cohort of 10- to 12-Year-Old UK Schoolboys: 2-Year Follow-up Data Free
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Ameet Shah; Gerassimos Lascaratos; David F. Garway-Heath; Paul J. Foster; Keith Barton
Tags: biometry, cohort studies, cornea, follow-up, immune reconstitution inflammatory syndrome
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4645-4650. doi:https://doi.org/10.1167/iovs.13-13757

Immunology and Microbiology

Decrease of Murine Cytomegalovirus–Induced Retinitis by Intravenous Delivery of Immediate Early Protein-3–Specific siRNA Free
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Brendan Marshall; Juan Mo; Jason Covar; Sally S. Atherton; Ming Zhang
Tags: proteins, retinitis, rna, small interfering, cytomegalovirus, mice
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4151-4157. doi:https://doi.org/10.1167/iovs.14-14375

Lens

Prevention of Posterior Capsule Opacification by an Intracapsular Open Capsule Device Free
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Roy Alon; Ehud I. Assia; Guy Kleinmann
Tags: after-cataract, eye, histology, prevention, hydrophobicity
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4005-4013. doi:https://doi.org/10.1167/iovs.14-14364
Translation, Cultural Adaptation, and Rasch Analysis of the Visual Function (VF-14) Questionnaire Free
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Jyoti Khadka; Jinhai Huang; Kaziwe Mollazadegan; Rongrong Gao; Haisi Chen; Sifang Zhang; Qinmei Wang; Konrad Pesudovs
Tags: chinese (other dialects), chinese people, questionnaires, rasch model, vision
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4413-4420. doi:https://doi.org/10.1167/iovs.14-14017

Multidisciplinary Ophthalmic Imaging

Microscopic Inner Retinal Hyper-Reflective Phenotypes in Retinal and Neurologic Disease Free
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Drew Scoles; Brian P. Higgins; Robert F. Cooper; Adam M. Dubis; Phyllis Summerfelt; David V. Weinberg; Judy E. Kim; Kimberly E. Stepien; Joseph Carroll; Alfredo Dubra
Tags: diagnostic imaging, nervous system disorders, phenotype, tissue membrane, optics
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4015-4029. doi:https://doi.org/10.1167/iovs.14-14668
In Vivo Imaging of Human Cone Photoreceptor Inner Segments Free
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Drew Scoles; Yusufu N. Sulai; Christopher S. Langlo; Gerald A. Fishman; Christine A. Curcio; Joseph Carroll; Alfredo Dubra
Tags: achromatopsia, diagnostic imaging, photoreceptors, retinal cone
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4244-4251. doi:https://doi.org/10.1167/iovs.14-14542
Spectral-Domain Optical Coherence Tomography Study on Dynamic Changes of Human Tears After Instillation of Artificial Tears Free
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Pietro Emanuele Napoli; Giovanni Maria Satta; Franco Coronella; Maurizio Fossarello
Tags: antithymoglobulin, arterial tortuosity syndrome, lipids, ocular lubricants, optical coherence tomography
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4533-4540. doi:https://doi.org/10.1167/iovs.14-14666

Physiology and Pharmacology

Retinal Blood Flow and Vascular Reactivity in Chronic Smokers Free
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Kalpana Rose; John G. Flanagan; Sunni R. Patel; Richard Cheng; Christopher Hudson
Tags: hypercapnia, smoking, vascular flow, ventricular rate rapid
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4266-4276. doi:https://doi.org/10.1167/iovs.14-14022
Experimental Evidence of Fluid Secretion of Rabbit Lacrimal Gland Duct Epithelium Free
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Máté Katona; Eszter Vizvári; Lukács Németh; Andrea Facskó; Viktória Venglovecz; Zoltán Rakonczay, Jr; Péter Hegyi; Edit Tóth-Molnár
Tags: bodily secretions, epithelium, forskolin, oryctolagus cuniculus, lacrimal gland
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4360-4367. doi:https://doi.org/10.1167/iovs.14-14025
Impact of P-Glycoprotein on Blood–Retinal Barrier Permeability: Comparison of Blood–Aqueous Humor and Blood–Brain Barrier Using Mdr1a Knockout Rats Free
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Shinobu Fujii; Chikako Setoguchi; Kouichi Kawazu; Ken-ichi Hosoya
Tags: aqueous humor, blood-brain barrier, permeability, p-glycoprotein, rats
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4650-4658. doi:https://doi.org/10.1167/iovs.13-13819
CD147 Required for Corneal Endothelial Lactate Transport Free
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Shimin Li; Tracy T. Nguyen; Joseph A. Bonanno
Tags: cornea, endothelium, lactates, rna, small interfering, biological transport
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4673-4681. doi:https://doi.org/10.1167/iovs.14-14386

Retina

Dysregulation of CXCR3 Expression on Peripheral Blood Leukocytes in Patients With Neovascular Age-Related Macular Degeneration Free
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Mads Krüger Falk; Amardeep Singh; Carsten Faber; Mogens Holst Nissen; Thomas Hviid; Torben Lykke Sørensen
Tags: exudative age-related macular degeneration, leukocytes, t-lymphocytes, chemokines
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4050-4056. doi:https://doi.org/10.1167/iovs.14-14107
Plasma Homocysteine Concentrations in Acute and Convalescent Changes of Central Retinal Vein Occlusion in a Chinese Population Free
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Ning Dong; Bing Xu; Xin Tang
Tags: central retinal vein occlusion, chinese (other dialects), chinese people, homocysteine, vitamin b12
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4057-4062. doi:https://doi.org/10.1167/iovs.14-14226
Strain Difference in Photoreceptor Cell Death After Retinal Detachment in Mice Free
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Hidetaka Matsumoto; Keiko Kataoka; Pavlina Tsoka; Kip M. Connor; Joan W. Miller; Demetrios G. Vavvas
Tags: mice, mice, inbred c57bl, photoreceptors, proteins, retinal detachment
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4165-4174. doi:https://doi.org/10.1167/iovs.14-14238
Uveal Melanoma Cell Growth Is Inhibited by Aminoimidazole Carboxamide Ribonucleotide (AICAR) Partially Through Activation of AMP-Dependent Kinase Free
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Ahmad Al-Moujahed; Fotini Nicolaou; Katarzyna Brodowska; Thanos D. Papakostas; Anna Marmalidou; Bruce R. Ksander; Joan W. Miller; Evangelos Gragoudas; Demetrios G. Vavvas
Tags: aica ribonucleotide, uveal melanoma, phosphotransferases, cell growth
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4175-4185. doi:https://doi.org/10.1167/iovs.13-12856
Relationship Between Foveal Cone Specialization and Pit Morphology in Albinism Free
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Melissa A. Wilk; John T. McAllister; Robert F. Cooper; Adam M. Dubis; Teresa N. Patitucci; Phyllis Summerfelt; Jennifer L. Anderson; Kimberly E. Stepien; Deborah M. Costakos; Thomas B. Connor, Jr; William J. Wirostko; Pei-Wen Chiang; Alfredo Dubra; Christine A. Curcio; Murray H. Brilliant; C. Gail Summers; Joseph Carroll
Tags: albinism, language morphology, morphology, retinal cone
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4186-4198. doi:https://doi.org/10.1167/iovs.13-13217
Effect of Diabetic Macular Edema on Peripapillary Retinal Nerve Fiber Layer Thickness Profiles Free
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Duck Jin Hwang; Eun Ji Lee; Sang Yoon Lee; Kyu Hyung Park; Se Joon Woo
Tags: diabetic macular edema, retinal nerve fiber layer, bevacizumab
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4213-4219. doi:https://doi.org/10.1167/iovs.13-13776
The Prevalence and Incidence of Epiretinal Membranes in Eyes With Inactive Extramacular CMV Retinitis Free
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Igor Kozak; Vijay Vaidya; Mark L. Van Natta; Jeong W. Pak; K. Patrick May; Jennifer E. Thorne; for the Studies of the Ocular Complications of AIDS Research Group
Tags: cytomegalovirus retinitis, epiretinal membrane, eye, incidence, prevalence
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4304-4312. doi:https://doi.org/10.1167/iovs.14-14479
Retinal Topography of Myopic Eyes: A Spectral-Domain Optical Coherence Tomography Study Free
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In Kyung Oh; Jaeryung Oh; Kyung-Sook Yang; Kyung Ho Lee; Seong-Woo Kim; Kuhl Huh
Tags: eye, optical coherence tomography, myopia
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4313-4319. doi:https://doi.org/10.1167/iovs.14-14277
Mitigation of Oxygen-Induced Retinopathy in α2β1 Integrin-Deficient Mice Free
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Aasakiran Madamanchi; Megan Capozzi; Ling Geng; Zhengzhi Li; Richard D. Friedman; S. Kent Dickeson; John S. Penn; Mary M. Zutter
Tags: integrins, mice, oxygen, retinal diseases, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4338-4347. doi:https://doi.org/10.1167/iovs.14-14061
Suppression of Choroidal Neovascularization Through Inhibition of APE1/Ref-1 Redox Activity Free
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Yue Li; Xiuli Liu; Tongrong Zhou; Mark R. Kelley; Paul A. Edwards; Hua Gao; Xiaoxi Qiao
Tags: choroidal neovascularization, oxidation-reduction, angiogenesis, bevacizumab, in situ nick-end labeling
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4461-4469. doi:https://doi.org/10.1167/iovs.14-14451
Protective and Antioxidant Effects of PPARα in the Ischemic Retina Free
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Elizabeth Moran; Lexi Ding; Zhongxiao Wang; Rui Cheng; Qian Chen; Robert Moore; Yusuke Takahashi; Jian-xing Ma
Tags: antioxidants, exhaled nitric oxide, in situ nick-end labeling, ischemia, retina
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4568-4576. doi:https://doi.org/10.1167/iovs.13-13127

Retinal Cell Biology

The Role of Cytochrome P450 Epoxygenases in Retinal Angiogenesis Free
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Megan E. Capozzi; Gary W. McCollum; John S. Penn
Tags: angiogenesis, astrocytes, cytochrome p450, hypoxia, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4253-4260. doi:https://doi.org/10.1167/iovs.14-14216
Cyclic Stretch and Hypertension Increase Retinal Succinate: Potential Mechanisms for Exacerbation of Ocular Neovascularization by Mechanical Stress Free
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Hirofumi Kinoshita; Kiyoshi Suzuma; Toshihide Maki; Yuki Maekawa; Makiko Matsumoto; Mao Kusano; Masafumi Uematsu; Takashi Kitaoka
Tags: hypertension, succinates, neovascularization, pathologic
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4320-4326. doi:https://doi.org/10.1167/iovs.13-13839
High Glucose Alters Cx43 Expression and Gap Junction Intercellular Communication in Retinal MĂĽller Cells: Promotes MĂĽller Cell and Pericyte Apoptosis Free
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Tetsuya Muto; Thomas Tien; Dongjoon Kim; Vijay P. Sarthy; Sayon Roy
Tags: apoptosis, connexin 43, pericytes, coculture techniques, gap junction protein
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4327-4337. doi:https://doi.org/10.1167/iovs.14-14606
Regulation of Intrinsic Axon Growth Ability at Retinal Ganglion Cell Growth Cones Free
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Michael B. Steketee; Carly Oboudiyat; Richard Daneman; Ephraim Trakhtenberg; Philip Lamoureux; Jessica E. Weinstein; Steve Heidemann; Ben A. Barres; Jeffrey L. Goldberg
Tags: axon, growth cones, retinal ganglion cells, regulation, growth rate
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4369-4377. doi:https://doi.org/10.1167/iovs.14-13882
Endogenous Fluorophores Enable Two-Photon Imaging of the Primate Eye Free
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Grazyna Palczewska; Marcin Golczak; David R. Williams; Jennifer J. Hunter; Krzysztof Palczewski
Tags: diagnostic imaging, eye, photons, primates, retina
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4438-4447. doi:https://doi.org/10.1167/iovs.14-14395
New Mouse Retinal Stroke Model Reveals Direction-Selective Circuit Damage Linked to Permanent Optokinetic Response Loss Free
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Sandrine Joly; Anna Guzik-Kornacka; Martin E. Schwab; Vincent Pernet
Tags: cerebrovascular accident, ischemia, ischemic stroke, mice, physiologic reperfusion
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4476-4489. doi:https://doi.org/10.1167/iovs.14-14521
Cluap1 is Essential for Ciliogenesis and Photoreceptor Maintenance in the Vertebrate Eye Free
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Chanjae Lee; John B. Wallingford; Jeffrey M. Gross
Tags: photoreceptors, vertebrates, eye, tissue degeneration, cilia
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4585-4592. doi:https://doi.org/10.1167/iovs.14-14888
The Role of Thrombin in Proliferative Vitreoretinopathy Free
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Jeroen Bastiaans; Jan C. van Meurs; Verena C. Mulder; Nicole M. A. Nagtzaam; Marja Smits-te Nijenhuis; Diana C. M. Dufour-van den Goorbergh; P. Martin van Hagen; Herbert Hooijkaas; Willem A. Dik
Tags: chemokines, cytokine, growth factor, thrombin, vitreoretinopathy, proliferative
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4659-4666. doi:https://doi.org/10.1167/iovs.14-14818
Decreased Proteasomal Activity Causes Photoreceptor Degeneration in Mice Free
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Ryo Ando; Kousuke Noda; Utano Tomaru; Mamoru Kamoshita; Yoko Ozawa; Shoji Notomi; Toshio Hisatomi; Mika Noda; Atsuhiro Kanda; Tatsuro Ishibashi; Masanori Kasahara; Susumu Ishida
Tags: animal model, mice, photoreceptors, tissue degeneration, aging
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4682-4690. doi:https://doi.org/10.1167/iovs.13-13272

Translational

Up-Regulation of VEGF by Retinoic Acid During Hyperoxia Prevents Retinal Neovascularization and Retinopathy Free
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Liya Wang; Pingling Shi; Zhongzhong Xu; Jing Li; Yanting Xie; Kenneth Mitton; Kimberly Drenser; Qi Yan
Tags: mice, retinal diseases, retinal neovascularization, tretinoin, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4276-4287. doi:https://doi.org/10.1167/iovs.14-14170
The Oral Iron Chelator Deferiprone Protects Against Systemic Iron Overload–Induced Retinal Degeneration in Hepcidin Knockout Mice Free
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Delu Song; Liangliang Zhao; Yafeng Li; Majda Hadziahmetovic; Ying Song; John Connelly; Michael Spino; Joshua L. Dunaief
Tags: deferiprone, hepcidin, iron chelating agents, iron overload, mice
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4525-4532. doi:https://doi.org/10.1167/iovs.14-14568

Visual Neuroscience

Examination of VLC-PUFA–Deficient Photoreceptor Terminals Free
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Lea D. Bennett; Blake R. Hopiavuori; Richard S. Brush; Michael Chan; Matthew J. Van Hook; Wallace B. Thoreson; Robert E. Anderson
Tags: mice, photoreceptors, polyunsaturated fatty acids, rod photoreceptors, retina
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4063-4072. doi:https://doi.org/10.1167/iovs.14-13997
Full-field Chromatic Pupillometry for the Assessment of the Postillumination Pupil Response Driven by Melanopsin-Containing Retinal Ganglion Cells Free
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Shaobo Lei; Herbert C. Goltz; Mano Chandrakumar; Agnes M. F. Wong
Tags: melanopsin, pupil reaction, pupillometry, retinal ganglion cells
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4496-4503. doi:https://doi.org/10.1167/iovs.14-14103
Relation Between Macular Retinal Ganglion Cell/Inner Plexiform Layer Thickness and Multifocal Electroretinogram Measures in Experimental Glaucoma Free
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Xunda Luo; Nimesh B. Patel; Lakshmi P. Rajagopalan; Ronald S. Harwerth; Laura J. Frishman
Tags: electroretinography, glaucoma, retinal ganglion cells, eye, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4512-4524. doi:https://doi.org/10.1167/iovs.14-13937

Review

The Role of the MRTF-A/SRF Pathway in Ocular Fibrosis Free
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Cynthia Yu-Wai-Man; Richard Treisman; Maryse Bailly; Peng Tee Khaw
Tags: fibrosis, cicatrix
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4560-4567. doi:https://doi.org/10.1167/iovs.14-14692

Letters to the Editor

Predicting and Preventing Visual Impairment and Blindness by Incorporating Individual Progression Velocity in Glaucoma Care Free
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Christiaan Wesselink; Nomdo M. Jansonius
Tags: blindness, glaucoma, velocity, visual impairment
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4470-4474. doi:https://doi.org/10.1167/iovs.14-14755
Author Response: Predicting and Preventing Visual Impairment and Blindness by Incorporating Individual Progression Velocity in Glaucoma Care Free
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Luke J. Saunders; Richard A. Russell; James F. Kirwan; Andrew I. McNaught; David P. Crabb
Tags: blindness, glaucoma, velocity, visual impairment
Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4475. doi:https://doi.org/10.1167/iovs.14-15049

Erratum

Erratum Free
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Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4041. doi:https://doi.org/10.1167/iovs.13-13387a
Erratum Free
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Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4164. doi:https://doi.org/10.1167/iovs.14-14166a
Erratum Free
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Investigative Ophthalmology & Visual Science July 2014, Vol.55, 4394. doi:https://doi.org/10.1167/iovs.13-12888b
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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