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Research Highlight

Hexokinase 1 and Retinitis Pigmentosa: Insights Into the Retina and the Molecule Free
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J. Fielding Hejtmancik
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7165. doi:https://doi.org/10.1167/iovs.14-15621
Fluorescence Lifetime for Studying Ophthalmic Diseases in Animal Models Free
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Mikhail Y. Berezin
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7216. doi:https://doi.org/10.1167/iovs.14-15769
Twin Study Implicates Genetic Factors in Dry Eye Disease Free
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Madeleine K. M. Adams
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7284. doi:https://doi.org/10.1167/iovs.14-15745
Mice With Cholesterol in Bruch's Membrane: Have We Arrived? Free
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Christine A. Curcio
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7296. doi:https://doi.org/10.1167/iovs.14-15858
A Glimpse at the Next Generation of Biological Eye Drops for Severe Ocular Surface Disease? Free
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Alex John Shortt
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7636. doi:https://doi.org/10.1167/iovs.14-15970

Anatomy and Pathology/Oncology

The Effects of Simultaneous Dual Focus Lenses on Refractive Development in Infant Monkeys Free
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Baskar Arumugam; Li-Fang Hung; Chi-ho To; Brien Holden; Earl L. Smith, III
Tags: cercopithecidae, eye, infant, lens (device), refractive errors
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7423-7432. doi:https://doi.org/10.1167/iovs.14-14250
Eyelid Closure in Embryogenesis Is Required for Ocular Adnexa Development Free
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Qinghang Meng; Maureen Mongan; Vinicius Carreira; Hisaka Kurita; Chia-yang Liu; Winston W.-Y. Kao; Ying Xia
Tags: eye, eyelid, mice, embryologic development, ocular adnexa
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7652-7661. doi:https://doi.org/10.1167/iovs.14-15155

Biochemistry and Molecular Biology

The Novel Rho Kinase (ROCK) Inhibitor K-115: A New Candidate Drug for Neuroprotective Treatment in Glaucoma Free
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Kotaro Yamamoto; Kazuichi Maruyama; Noriko Himori; Kazuko Omodaka; Yu Yokoyama; Yukihiro Shiga; Ryu Morin; Toru Nakazawa
Tags: glaucoma, kinase inhibitors, phosphotransferases, wounds and injuries, oxidative stress
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7126-7136. doi:https://doi.org/10.1167/iovs.13-13842

Clinical and Epidemiologic Research

Clinical Characteristics of Familial and Sporadic Age-Related Macular Degeneration: Differences and Similarities Free
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Nicole T. M. Saksens; Eveline Kersten; Joannes M. M. Groenewoud; Mark J. J. P. van Grinsven; Johannes P. H. van de Ven; Clara I. Sánchez; Tina Schick; Sascha Fauser; Anneke I. den Hollander; Carel B. Hoyng; Camiel J. F. Boon
Tags: age-related macular degeneration, drusen, family, medical history, phenotype
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7085-7092. doi:https://doi.org/10.1167/iovs.14-14659
Identification of Vinculin as a Potential Plasma Marker for Age-Related Macular Degeneration Free
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Hye-Jung Kim; Se Joon Woo; Eui Jin Suh; Jeeyun Ahn; Ji Hyun Park; Hye Kyoung Hong; Ji Eun Lee; Seong Joon Ahn; Duck Jin Hwang; Ki Woong Kim; Kyu Hyung Park; Cheolju Lee
Tags: age-related macular degeneration, plasma, proteins, vinculin, plasma proteins
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7166-7176. doi:https://doi.org/10.1167/iovs.14-15168
Visual Impairment and the Incidence of Falls and Fractures Among Older People: Longitudinal Findings From the Blue Mountains Eye Study Free
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Thomas Hong; Paul Mitchell; George Burlutsky; Chameen Samarawickrama; Jie Jin Wang
Tags: fractures, visual impairment, older adult, eye, incidence
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7589-7593. doi:https://doi.org/10.1167/iovs.14-14262
Lifetime Exposure to Ambient Ultraviolet Radiation and the Risk for Cataract Extraction and Age-Related Macular Degeneration: The Alienor Study Free
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Cécile Delcourt; Audrey Cougnard-Grégoire; Mathieu Boniol; Isabelle Carrière; Jean-François Doré; Marie-Noëlle Delyfer; Marie-Bénédicte Rougier; Mélanie Le Goff; Jean-François Dartigues; Pascale Barberger-Gateau; Jean-François Korobelnik
Tags: age-related macular degeneration, cataract, cataract surgery, ultraviolet rays, sunlight
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7619-7627. doi:https://doi.org/10.1167/iovs.14-14471

Cornea

Transethnic Replication of Association of CTG18.1 Repeat Expansion of TCF4 Gene With Fuchs' Corneal Dystrophy in Chinese Implies Common Causal Variant Free
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Chao Xing; Xin Gong; Imran Hussain; Chiea-Chuen Khor; Donald T. H. Tan; Tin Aung; Jodhbir S. Mehta; Eranga N. Vithana; V. Vinod Mootha
Tags: alleles, chinese (other dialects), chinese people, genes, hereditary corneal dystrophy
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7073-7078. doi:https://doi.org/10.1167/iovs.14-15390
Establishing PAX6 as a Biomarker to Detect Early Loss of Ocular Phenotype in Human Patients With Sjögren's Syndrome Free
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Nancy A. McNamara; Marianne Gallup; Travis C. Porco
Tags: biological markers, dry eye syndromes, inflammation, phenotype, sjogren's syndrome
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7079-7084. doi:https://doi.org/10.1167/iovs.14-14828
Antimicrobial Role of Human Meibomian Lipids at the Ocular Surface Free
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Poonam Mudgil
Tags: antimicrobials, lipids
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7272-7277. doi:https://doi.org/10.1167/iovs.14-15512
Neuron J is a Rapid and Reliable Open Source Tool for Evaluating Corneal Nerve Density in Herpes Simplex Keratitis Free
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Paul Cottrell; Sohail Ahmed; Catherine James; James Hodson; Peter J. McDonnell; Saaeha Rauz; Geraint P. Williams
Tags: cornea, keratitis, herpetic, neurons, reliability
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7312-7320. doi:https://doi.org/10.1167/iovs.14-15140
Intrastromal Delivery of Bevacizumab Using Microneedles to Treat Corneal Neovascularization Free
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Yoo C. Kim; Hans E. Grossniklaus; Henry F. Edelhauser; Mark R. Prausnitz
Tags: bevacizumab, corneal neovascularization
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7376-7386. doi:https://doi.org/10.1167/iovs.14-15257
Correlation Between Human Tear Cytokine Levels and Cellular Corneal Changes in Patients With Bacterial Keratitis by In Vivo Confocal Microscopy Free
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Takefumi Yamaguchi; Bernardo M. Calvacanti; Andrea Cruzat; Yureeda Qazi; Shizu Ishikawa; Akinori Osuka; James Lederer; Pedram Hamrah
Tags: cornea, cytokine, bacterial keratitis, microscopy, confocal, neurons
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7457-7466. doi:https://doi.org/10.1167/iovs.14-15411
In Vivo Evidence of Porcine Cornea Anisotropy Using Supersonic Shear Wave Imaging Free
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Thu-Mai Nguyen; Jean-Francois Aubry; Mathias Fink; Jeremy Bercoff; Mickael Tanter
Tags: anisotropy, cornea, diagnostic imaging, suidae
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7545-7552. doi:https://doi.org/10.1167/iovs.14-15127
Human Corneal Stromal Stem Cells Exhibit Survival Capacity Following Isolation From Stored Organ–Culture Corneas Free
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Alvena K. Kureshi; James L. Funderburgh; Julie T. Daniels
Tags: cornea, keratocytes, language morphology, mesenchymal stem cells, morphology
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7583-7588. doi:https://doi.org/10.1167/iovs.14-14448
Optical Coherence Tomography and Confocal Microscopy Following Three Different Protocols of Corneal Collagen-Crosslinking in Keratoconus Free
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Nacim Bouheraoua; Lea Jouve; Mohamed El Sanharawi; Otman Sandali; Cyrille Temstet; Patrick Loriaut; Elena Basli; Vincent Borderie; Laurent Laroche
Tags: cornea, corneal collagen cross-linking, keratoconus, microscopy, confocal, optical coherence tomography
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7601-7609. doi:https://doi.org/10.1167/iovs.14-15662
Cell Surface Markers of Functional Phenotypic Corneal Endothelial Cells Free
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Naoki Okumura; Hiroatsu Hirano; Ryohei Numata; Makiko Nakahara; Morio Ueno; Junji Hamuro; Shigeru Kinoshita; Noriko Koizumi
Tags: 5'-nucleotidase, chronic exertional compartment syndrome, cornea, endothelial cells, phenotype
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7610-7618. doi:https://doi.org/10.1167/iovs.14-14980
Effects of Mesenchymal Stem/Stromal Cells on Cultures of Corneal Epithelial Progenitor Cells With Ethanol Injury Free
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Joo Youn Oh; Jung Hwa Ko; Mee Kum Kim; Won Ryang Wee
Tags: cornea, epithelium, ethanol, stem cells, stromal cells
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7628-7635. doi:https://doi.org/10.1167/iovs.14-15424

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Sustained Neuroprotection From a Single Intravitreal Injection of PGJ2 in a Nonhuman Primate Model of Nonarteritic Anterior Ischemic Optic Neuropathy Free
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Neil R. Miller; Mary A. Johnson; Theresa Nolan; Yan Guo; Alexander M. Bernstein; Steven L. Bernstein
Tags: eye, intravitreal injections, neuroprotection, nonarteritic anterior ischemic optic neuropathy, primates
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7047-7056. doi:https://doi.org/10.1167/iovs.14-14063
Severe, Early Axonal Degeneration Following Experimental Anterior Ischemic Optic Neuropathy Free
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Gun Ho Lee; Madison P. Stanford; Mohammad A. Shariati; Jeffrey H. Ma; Yaping Joyce Liao
Tags: annexins, anterior ischemic optic neuropathy, axon, mice, optic neuropathy, ischemic
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7111-7118. doi:https://doi.org/10.1167/iovs.14-14603
Degradation of Swept-Parameter VEP Responses by Neutral Density Filters in Amblyopic and Normal Subjects Free
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Amanda L. Ely; Joel M. Weinstein; Jade M. Price; Jason T. Gillon; Marianne E. Boltz; Stephen F. Mowery; Ardalan Aminlari; Rick O. Gilmore; Albert Y. Cheung
Tags: amblyopia, eye, catabolism, evoked potentials, visual, filters
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7248-7255. doi:https://doi.org/10.1167/iovs.14-15052
Macular Choroidal Thickness in Unilateral Amblyopic Children Free
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Jinling Xu; Jingwei Zheng; Shujuan Yu; Zuhua Sun; Weiwei Zheng; Peng Qu; Yuanyuan Chen; Wuhe Chen; Xinping Yu
Tags: amblyopia, child, eye
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7361-7368. doi:https://doi.org/10.1167/iovs.14-14439

Genetics

A Dominant Mutation in Hexokinase 1 (HK1) Causes Retinitis Pigmentosa Free
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Lori S. Sullivan; Daniel C. Koboldt; Sara J. Bowne; Steven Lang; Susan H. Blanton; Elizabeth Cadena; Cheryl E. Avery; Richard A. Lewis; Kaylie Webb-Jones; Dianna H. Wheaton; David G. Birch; Razck Coussa; Huanan Ren; Irma Lopez; Christina Chakarova; Robert K. Koenekoop; Charles A. Garcia; Robert S. Fulton; Richard K. Wilson; George M. Weinstock; Stephen P. Daiger
Tags: genes, hexokinase, mutation, retinitis pigmentosa, family
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7147-7158. doi:https://doi.org/10.1167/iovs.14-15419
A Missense Mutation in HK1 Leads to Autosomal Dominant Retinitis Pigmentosa Free
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Feng Wang; Yandong Wang; Bin Zhang; Li Zhao; Vera Lyubasyuk; Keqing Wang; Mingchu Xu; Yumei Li; Frances Wu; Cindy Wen; Paul S. Bernstein; Danni Lin; Susanna Zhu; Hui Wang; Kang Zhang; Rui Chen
Tags: genetic linkage analysis, missense mutation, mutation, retinitis pigmentosa, whole exome sequencing
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7159-7164. doi:https://doi.org/10.1167/iovs.14-15520
The Heritability of Dry Eye Disease in a Female Twin Cohort Free
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Jelle Vehof; Bin Wang; Diana Kozareva; Pirro G. Hysi; Harold Snieder; Christopher J. Hammond
Tags: cohort studies, dry eye syndromes, twins, signs and symptoms
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7278-7283. doi:https://doi.org/10.1167/iovs.14-15200
Comprehensive Replication of the Relationship Between Myopia-Related Genes and Refractive Errors in a Large Japanese Cohort Free
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Munemitsu Yoshikawa; Kenji Yamashiro; Masahiro Miyake; Maho Oishi; Yumiko Akagi-Kurashige; Kyoko Kumagai; Isao Nakata; Hideo Nakanishi; Akio Oishi; Norimoto Gotoh; Ryo Yamada; Fumihiko Matsuda; Nagahisa Yoshimura; for the Nagahama Study Group
Tags: cohort studies, genes, japanese, myopia, refractive errors
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7343-7354. doi:https://doi.org/10.1167/iovs.14-15105
Contribution of Mutation Load to the Intrafamilial Genetic Heterogeneity in a Large Cohort of Spanish Retinal Dystrophies Families Free
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Rocío Sánchez-Alcudia; Marta Cortón; Almudena Ávila-Fernández; Olga Zurita; Sorina D. Tatu; Raquel Pérez-Carro; Patricia Fernandez-San Jose; Miguel Ángel Lopez-Martinez; Francisco J. del Castillo; Jose M. Millan; Fiona Blanco-Kelly; Blanca García-Sandoval; Maria Isabel Lopez-Molina; Rosa Riveiro-Alvarez; Carmen Ayuso
Tags: cohort studies, family, genes, genetic heterogeneity, mutation
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7562-7571. doi:https://doi.org/10.1167/iovs.14-14938
Genetic Association of TCF4 Intronic Polymorphisms, CTG18.1 and rs17089887, With Fuchs' Endothelial Corneal Dystrophy in an Indian Population Free
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Gargi Gouranga Nanda; Biswajit Padhy; Sujata Samal; Sujata Das; Debasmita Pankaj Alone
Tags: endothelium, genetics, hereditary corneal dystrophy, introns, polymorphism
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7674-7680. doi:https://doi.org/10.1167/iovs.14-15297

Glaucoma

Neural Stem Cell–Based Intraocular Administration of Ciliary Neurotrophic Factor Attenuates the Loss of Axotomized Ganglion Cells in Adult Mice Free
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Kai Flachsbarth; Katharina Kruszewski; Gila Jung; Wanda Jankowiak; Kristoffer Riecken; Lars Wagenfeld; Gisbert Richard; Boris Fehse; Udo Bartsch
Tags: ciliary neurotrophic factor, mice, neural stem cells, adult, ganglia
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7029-7039. doi:https://doi.org/10.1167/iovs.14-15266
Induction of Trabecular Meshwork Cells From Induced Pluripotent Stem Cells Free
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Qiong J. Ding; Wei Zhu; Amy C. Cook; Kristin R. Anfinson; Budd A. Tucker; Markus H. Kuehn
Tags: pluripotent stem cells, trabecular meshwork, cell culture techniques, glaucoma, myoc gene
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7065-7072. doi:https://doi.org/10.1167/iovs.14-14800
Human Scleral Structural Stiffness Increases More Rapidly With Age in Donors of African Descent Compared to Donors of European Descent Free
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Massimo A. Fazio; Rafael Grytz; Jeffrey S. Morris; Luigi Bruno; Christopher A. Girkin; J. Crawford Downs
Tags: continental population groups, donors, sclera, eye
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7189-7198. doi:https://doi.org/10.1167/iovs.14-14894
Relationship Between Macular Inner Retinal Layer Thickness and Corresponding Retinal Sensitivity in Normal Eyes Free
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Makoto Araie; Hitomi Saito; Atsuo Tomidokoro; Hiroshi Murata; Aiko Iwase
Tags: eye, glaucoma, refraction
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7199-7205. doi:https://doi.org/10.1167/iovs.14-14964
Cerebral Microinfarcts in Primary Open-Angle Glaucoma Correlated With DTI-Derived Integrity of Optic Radiation Free
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Johannes Schoemann; Tobias Engelhorn; Simone Waerntges; Arnd Doerfler; Ahmed El-Rafei; Georg Michelson
Tags: brain, open-angle glaucoma, optic radiation, personal integrity
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7241-7247. doi:https://doi.org/10.1167/iovs.14-14919
A Comprehensive Model for Correcting RNFL Readings of Varying Signal Strengths in Cirrus Optical Coherence Tomography Free
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David J. Russell; Shamis Fallah; Christopher J. Loer; Robert H. Riffenburgh
Tags: reading (activity), retinal nerve fiber layer, optical coherence tomography
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7297-7302. doi:https://doi.org/10.1167/iovs.14-14993
Influence of the Disc–Fovea Angle on Limits of RNFL Variability and Glaucoma Discrimination Free
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Navid Amini; Sara Nowroozizadeh; Nila Cirineo; Sharon Henry; Ted Chang; Tom Chou; Anne L. Coleman; Joseph Caprioli; Kouros Nouri-Mahdavi
Tags: fovea centralis, glaucoma, retinal nerve fiber layer, eye
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7332-7342. doi:https://doi.org/10.1167/iovs.14-14962
Asymmetry of Habitual 24-Hour Intraocular Pressure Rhythm in Glaucoma Patients Free
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John H. K. Liu; Robert N. Weinreb
Tags: glaucoma, intraocular pressure, rhythm, eye
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7398-7402. doi:https://doi.org/10.1167/iovs.14-14464
Anterior Segment Optical Coherence Tomography Parameters in Phacomorphic Angle Closure and Mature Cataracts Free
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Mohammadreza Mansouri; Farshid Ramezani; Sasan Moghimi; Ali Tabatabaie; Fatemeh Abdi; Mingguang He; Shan C. Lin
Tags: cataract, eye, optical coherence tomography, risk factors, lens, crystalline
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7403-7409. doi:https://doi.org/10.1167/iovs.14-14748
Canonical Wnt Signaling Regulates Extracellular Matrix Expression in the Trabecular Meshwork Free
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Guadalupe Villarreal, Jr; Ayan Chatterjee; Sarah S. Oh; Dong-Jin Oh; Min Hyung Kang; Douglas J. Rhee
Tags: extracellular matrix, lithium chloride, proteins, signal transduction, trabecular meshwork
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7433-7440. doi:https://doi.org/10.1167/iovs.13-12652
Influences of the Inner Retinal Sublayers and Analytical Areas in Macular Scans by Spectral-Domain OCT on the Diagnostic Ability of Early Glaucoma Free
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Yusuke Nakatani; Tomomi Higashide; Shinji Ohkubo; Kazuhisa Sugiyama
Tags: glaucoma
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7479-7485. doi:https://doi.org/10.1167/iovs.14-15530
Acetylation Preserves Retinal Ganglion Cell Structure and Function in a Chronic Model of Ocular Hypertension Free
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Oday Alsarraf; Jie Fan; Mohammad Dahrouj; C. James Chou; Phillip W. Yates; Craig E. Crosson
Tags: acetylation, histone deacetylase, ocular hypertension, retina, retinal ganglion cells
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7486-7493. doi:https://doi.org/10.1167/iovs.14-14792
Identification of Adult Stem Cells in Schwalbe's Line Region of the Primate Eye Free
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Barbara M. Braunger; Bahar Ademoglu; Sebastian E. Koschade; Rudolf Fuchshofer; B'Ann T. Gabelt; Julie A. Kiland; Elizabeth A. Hennes-Beann; Kevin G. Brunner; Paul L. Kaufman; Ernst R. Tamm
Tags: adult, bromodeoxyuridine, eye, line of schwalbe, primates
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7499-7507. doi:https://doi.org/10.1167/iovs.14-14872
In Vivo Testing of a Novel Adjustable Glaucoma Drainage Device Free
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Adan Villamarin; Nikos Stergiopulos; Stéphane Bigler; André Mermoud; Alexandre Moulin; Sylvain Roy
Tags: glaucoma drainage implants, intraocular pressure, eye
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7520-7524. doi:https://doi.org/10.1167/iovs.14-14563
Clustering Visual Field Test Points Based on Rates of Progression to Improve the Prediction of Future Damage Free
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Kazunori Hirasawa; Hiroshi Murata; Hiroyo Hirasawa; Chihiro Mayama; Ryo Asaoka
Tags: glaucoma, visual field testing
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7681-7685. doi:https://doi.org/10.1167/iovs.14-15040

Immunology and Microbiology

Role of Bax in Death of Uninfected Retinal Cells During Murine Cytomegalovirus Retinitis Free
PDF
Juan Mo; Brendan Marshall; Jason Covar; Nancy Y. Zhang; Sylvia B. Smith; Sally S. Atherton; Ming Zhang
Tags: apoptosis, caspase-3, cytomegalovirus retinitis, eye, mice
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7137-7146. doi:https://doi.org/10.1167/iovs.14-15404
Hyaluronic Acid Induces COX-2 Expression via CD44 in Orbital Fibroblasts From Patients With Thyroid-Associated Ophthalmopathy Free
PDF
Hun Sub Lim; Keum Ok Back; Hee Ja Kim; Youn-Hee Choi; Young Mi Park; Koung Hoon Kook
Tags: cd44 antigens, cyclooxygenase-2, fibroblasts, graves' ophthalmopathy, hyaluronic acid
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7441-7450. doi:https://doi.org/10.1167/iovs.14-14873
Experimental Autoimmune Uveoretinitis (EAU)-Related Tissue Damage and Angiogenesis Is Reduced in CCL2−/−CX3CR1gfp/gfp Mice Free
PDF
Jiawu Zhao; Mei Chen; Heping Xu
Tags: angiogenesis, autoimmune diseases, mice, monocyte chemoattractant protein-1, tissue damage
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7572-7582. doi:https://doi.org/10.1167/iovs.14-15495

Lens

An In Vitro Evaluation of the Anew Zephyr Open-Bag IOL in the Prevention of Posterior Capsule Opacification Using a Human Capsular Bag Model Free
PDF
Julie A. Eldred; David J. Spalton; I. Michael Wormstone
Tags: after-cataract, prevention, eye
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7057-7064. doi:https://doi.org/10.1167/iovs.14-15302
Expression of the HSF4 DNA Binding Domain-EGFP Hybrid Gene Recreates Early Childhood Lamellar Cataract in Transgenic Mice Free
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Rajendra K. Gangalum; Zhe Jing; Ankur M. Bhat; Josh Lee; Yoshiko Nagaoka; Sophie X. Deng; Meisheng Jiang; Suraj P. Bhat
Tags: animals, transgenic, cataract, cell nucleus, child, dna
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7227-7240. doi:https://doi.org/10.1167/iovs.14-14594

Multidisciplinary Ophthalmic Imaging

Ultra-Widefield Fluorescein Angiographic Findings in Patients With Recurrent Vitreous Hemorrhage After Diabetic Vitrectomy Free
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Dong Yoon Kim; June-Gone Kim; Yoon Jeon Kim; Soo Geun Joe; Joo Yong Lee
Tags: angiogram, diabetes mellitus, fluorescein, recurrence, vitrectomy
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7040-7046. doi:https://doi.org/10.1167/iovs.14-15112
Retinal Sensitivity Is Reduced in Patients With Obstructive Sleep Apnea Free
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Blanca Ferrandez; Antonio Ferreras; Pilar Calvo; Beatriz Abadia; Paolo Fogagnolo; Yaowu Wang; Jose M. Marin; Michele Iester
Tags: obstructive sleep apnea, visual fields, glaucoma, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7119-7125. doi:https://doi.org/10.1167/iovs.14-14389
Change in Drusen Area Over Time Compared Using Spectral-Domain Optical Coherence Tomography and Color Fundus Imaging Free
PDF
Giovanni Gregori; Zohar Yehoshua; Carlos Alexandre de Amorim Garcia Filho; SriniVas R. Sadda; Renata Portella Nunes; William J. Feuer; Philip J. Rosenfeld
Tags: color, diagnostic imaging, drusen, optical coherence tomography
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7662-7668. doi:https://doi.org/10.1167/iovs.14-15273
Automated Analysis of Angle Closure From Anterior Chamber Angle Images Free
PDF
Mani Baskaran; Jun Cheng; Shamira A. Perera; Tin A. Tun; Jiang Liu; Tin Aung
Tags: anterior chamber of eye, gonioscopy
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7669-7673. doi:https://doi.org/10.1167/iovs.14-14852
Peripapillary Rat Sclera Investigated In Vivo With Polarization-Sensitive Optical Coherence Tomography Free
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Bernhard Baumann; Sabine Rauscher; Martin Glösmann; Erich Götzinger; Michael Pircher; Stanislava Fialová; Marion Gröger; Christoph K. Hitzenberger
Tags: diagnostic imaging, eye, optical coherence tomography, sclera, birefringence
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7686-7696. doi:https://doi.org/10.1167/iovs.14-15037

Physiology and Pharmacology

CoQ10-Containing Eye Drops Prevent UVB-Induced Cornea Cell Damage and Increase Cornea Wound Healing by Preserving Mitochondrial Function Free
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Rita Mencucci; Eleonora Favuzza; Carlotta Boccalini; Andrea Lapucci; Roberta Felici; Francesco Resta; Alberto Chiarugi; Leonardo Cavone
Tags: coenzyme q10, cornea, eyedrops, mitochondria, ophthalmic solutions
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7266-7271. doi:https://doi.org/10.1167/iovs.14-15306
Targeted Delivery of Antiglaucoma Drugs to the Supraciliary Space Using Microneedles Free
PDF
Yoo C. Kim; Henry F. Edelhauser; Mark R. Prausnitz
Tags: antiglaucoma agents, brimonidine, eye, intraocular pressure, oryctolagus cuniculus
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7387-7397. doi:https://doi.org/10.1167/iovs.14-14651
Effects of Dopaminergic Agents on Progression of Naturally Occurring Myopia in Albino Guinea Pigs (Cavia porcellus) Free
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Liqin Jiang; Keli Long; Frank Schaeffel; Xiangtian Zhou; Yibo Zheng; Huangfang Ying; Fan Lu; William K. Stell; Jia Qu
Tags: albinism, caviidae, dopamine, myopia, eye
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7508-7519. doi:https://doi.org/10.1167/iovs.14-14294
Transcriptomic Profiling Explains Racial Disparities in Pterygium Patients Treated With Doxycycline Free
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Ignacio M. Larrayoz; Óscar Rúa; Sara Velilla; Alfredo Martínez
Tags: doxycycline, pterygium, hispanics or latinos, european continental ancestry group, racial disparities
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7553-7561. doi:https://doi.org/10.1167/iovs.14-14951

Retina

Quantitative SD-OCT Imaging Biomarkers as Indicators of Age-Related Macular Degeneration Progression Free
PDF
Luis de Sisternes; Noah Simon; Robert Tibshirani; Theodore Leng; Daniel L. Rubin
Tags: age-related macular degeneration, biological markers, diagnostic imaging, drusen, eye
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7093-7103. doi:https://doi.org/10.1167/iovs.14-14918
Reliability and Determinants of Retinal Vessel Oximetry Measurements in Healthy Eyes Free
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WanFen Yip; Rosalynn Siantar; Shamira A. Perera; Nia Milastuti; Kee Ka Ho; Bernard Tan; Tien Yin Wong; Carol Y. Cheung
Tags: eye, oximetry, reliability, retinal vessels
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7104-7110. doi:https://doi.org/10.1167/iovs.13-13854
Structural and Genetic Assessment of the ABCA4-Associated Optical Gap Phenotype Free
PDF
Kalev Nõupuu; Winston Lee; Jana Zernant; Stephen H. Tsang; Rando Allikmets
Tags: genetics, optics, phenotype
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7217-7226. doi:https://doi.org/10.1167/iovs.14-14674
Mice That Produce ApoB100 Lipoproteins in the RPE Do Not Develop Drusen yet Are Still a Valuable Experimental System Free
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Masashi Fujihara; Marisol Cano; James T. Handa
Tags: drusen, lipoproteins, mice, bruch's basal membrane, lipids
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7285-7295. doi:https://doi.org/10.1167/iovs.14-15195
Mechanisms of Endothelial to Mesenchymal Transition in the Retina in Diabetes Free
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Yanan Cao; Biao Feng; Shali Chen; Yanhui Chu; Subrata Chakrabarti
Tags: diabetes mellitus, endothelium, glucose, retina, rna, messenger
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7321-7331. doi:https://doi.org/10.1167/iovs.14-15167
Comprehensive Molecular Diagnosis of a Large Cohort of Japanese Retinitis Pigmentosa and Usher Syndrome Patients by Next-Generation Sequencing Free
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Maho Oishi; Akio Oishi; Norimoto Gotoh; Ken Ogino; Koichiro Higasa; Kei Iida; Yukiko Makiyama; Satoshi Morooka; Fumihiko Matsuda; Nagahisa Yoshimura
Tags: cohort studies, genes, japanese, massively-parallel genome sequencing, molecular diagnostic techniques
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7369-7375. doi:https://doi.org/10.1167/iovs.14-15458
Macular Measurements Using Spectral-Domain Optical Coherence Tomography in Chinese Myopic Children Free
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Si Chen; Bingsong Wang; Ning Dong; Xiaofang Ren; Tuohong Zhang; Lin Xiao
Tags: child, chinese (other dialects), chinese people, optical coherence tomography, volume
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7410-7416. doi:https://doi.org/10.1167/iovs.14-13894
A Comparison of Progressive Loss of the Ellipsoid Zone (EZ) Band in Autosomal Dominant and X-Linked Retinitis Pigmentosa Free
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Cindy X. Cai; Kirsten G. Locke; Rithambara Ramachandran; David G. Birch; Donald C. Hood
Tags: retinitis pigmentosa, x-linked inheritance
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7417-7422. doi:https://doi.org/10.1167/iovs.14-15013
Factors Influencing the Shear Rate Acting on Silicone Oil to Cause Silicone Oil Emulsification Free
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Yau Kei Chan; Ning Cheung; David Wong
Tags: emulsification, eye, silicone oils, velocity, viscosity
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7451-7456. doi:https://doi.org/10.1167/iovs.14-14572
Foveal Sparing in Stargardt Disease Free
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Ramon A. C. van Huet; Nathalie M. Bax; Sarah C. Westeneng-Van Haaften; Muhamad Muhamad; Marijke N. Zonneveld-Vrieling; Lies H. Hoefsloot; Frans P. M. Cremers; Camiel J. F. Boon; B. Jeroen Klevering; Carel B. Hoyng
Tags: atrophy, fovea centralis, stargardt's disease, mutation, eye
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7467-7478. doi:https://doi.org/10.1167/iovs.13-13825
Influence of Axial Length on Thickness Measurements Using Spectral-Domain Optical Coherence Tomography Free
PDF
Tobias Röck; Karl Ulrich Bartz-Schmidt; Matthias Bramkamp; Daniel Röck
Tags: eye, implants, optical coherence tomography
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7494-7498. doi:https://doi.org/10.1167/iovs.14-14043
New Wrinkles in Retinal Densitometry Free
PDF
Benjamin D. Masella; Jennifer J. Hunter; David R. Williams
Tags: densitometry, recovery of function, rhodopsin, skin wrinkling, pigment
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7525-7534. doi:https://doi.org/10.1167/iovs.13-13795
Rod Photopigment Kinetics After Photodisruption of the Retinal Pigment Epithelium Free
PDF
Benjamin D. Masella; Jennifer J. Hunter; David R. Williams
Tags: densitometry, kinetics, photodisruption, photoreceptors, retinal pigment epithelium
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7535-7544. doi:https://doi.org/10.1167/iovs.13-13796
Contrast Sensitivity and Foveal Microstructure Following Vitrectomy for Epiretinal Membrane Free
PDF
Yoshimi Sugiura; Fumiki Okamoto; Yoshifumi Okamoto; Takahiro Hiraoka; Tetsuro Oshika
Tags: contrast sensitivity, epiretinal membrane, postoperative care, visual acuity, vitrectomy
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7594-7600. doi:https://doi.org/10.1167/iovs.14-14035

Retinal Cell Biology

Fluorescence Lifetime Imaging of the Ocular Fundus in Mice Free
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Chantal Dysli; Muriel Dysli; Volker Enzmann; Sebastian Wolf; Martin S. Zinkernagel
Tags: diagnostic imaging, fluorescence, mice, ophthalmoscopy, retina
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7206-7215. doi:https://doi.org/10.1167/iovs.14-14445
Epigenetic Modifications of Keap1 Regulate Its Interaction With the Protective Factor Nrf2 in the Development of Diabetic Retinopathy Free
PDF
Manish Mishra; Qing Zhong; Renu A. Kowluru
Tags: diabetes mellitus, diabetic retinopathy, epigenetics, glucose, protective factors
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7256-7265. doi:https://doi.org/10.1167/iovs.14-15193

Visual Psychophysics and Physiological Optics

Genotype-Dependent Variability in Residual Cone Structure in Achromatopsia: Toward Developing Metrics for Assessing Cone Health Free
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Adam M. Dubis; Robert F. Cooper; Jonathan Aboshiha; Christopher S. Langlo; Venki Sundaram; Benjamin Liu; Frederick Collison; Gerald A. Fishman; Anthony T. Moore; Andrew R. Webster; Alfredo Dubra; Joseph Carroll; Michel Michaelides
Tags: achromatopsia, diagnostic imaging, genotype, health, personal integrity
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7303-7311. doi:https://doi.org/10.1167/iovs.14-14225

Clinical Trials

Myopia Control With Positively Aspherized Progressive Addition Lenses: A 2-Year, Multicenter, Randomized, Controlled Trial Free
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Satoshi Hasebe; Jiang Jun; Saulius R. Varnas
Tags: lens (device), myopia, papillon-lefevre disease, pediatric advanced life support, periarterial lymphatic sheath
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7177-7188. doi:https://doi.org/10.1167/iovs.12-11462

Review

Transgenic Mouse Models of Corneal Neovascularization: New Perspectives for Angiogenesis Research Free
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Jakob Nikolas Kather; Jens Kroll
Tags: angiogenesis, cornea, mice, mice, transgenic, animals, transgenic
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7637-7651. doi:https://doi.org/10.1167/iovs.14-15430

New Developments in Vision Research

The RD5000 Database: Facilitating Clinical, Genetic, and Therapeutic Studies on Inherited Retinal Diseases Free
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Ramon A. C. van Huet; Clasien J. Oomen; Astrid S. Plomp; Maria M. van Genderen; B. Jeroen Klevering; Reinier O. Schlingemann; Caroline C. W. Klaver; L. Ingeborgh van den Born; Frans P. M. Cremers; the RD5000 Study Group
Tags: genetics, retinal diseases
Investigative Ophthalmology & Visual Science November 2014, Vol.55, 7355-7360. doi:https://doi.org/10.1167/iovs.14-15317
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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