Volume 45 Issue 12 | IOVS

Anatomy and Pathology/Oncology

Laminin Isoforms in Human Extraocular Muscles Free

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Daniel Kjellgren; Lars-Eric Thornell; Ismo Virtanen; Fatima Pedrosa-Domellöf

Tags: blood capillaries, laminin, muscle, muscle of orbit, protein isoforms

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4233-4239. doi:https://doi.org/10.1167/iovs.04-0456

Expression and Possible Function of IL-2 and IL-15 Receptors on Human Uveal Melanoma Cells Free

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Yu-Guang He; Elizabeth Mayhew; Jessamee Mellon; Jerry Y. Niederkorn

Tags: aldesleukin, interleukin-15, uveal melanoma, melanoma, apoptosis

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4240-4246. doi:https://doi.org/10.1167/iovs.04-0599

EpCAM Expression in Retinoblastoma: A Novel Molecular Target for Therapy Free

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Subramanian Krishnakumar; Adithi Mohan; Kandalam Mallikarjuna; Nalini Venkatesan; Jyotirmay Biswas; Mahesh Palanivelu Shanmugam; Lifen Ren-Heidenreich

Tags: epcam gene, molecular target, neoplasms, retinoblastoma

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4247-4250. doi:https://doi.org/10.1167/iovs.04-0591

Neurally Selected Embryonic Stem Cells Induce Tumor Formation after Long-Term Survival following Engraftment into the Subretinal Space Free

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Stefan Arnhold; Helmut Klein; Irina Semkova; Klaus Addicks; Ulrich Schraermeyer

Tags: embryonic stem cells, engraftment, neoplasms, transplantation

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4251-4255. doi:https://doi.org/10.1167/iovs.03-1108

Biochemistry and Molecular Biology

Variant Phenotypes of Incomplete Achromatopsia in Two Cousins with GNAT2 Gene Mutations Free

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Thomas Rosenberg; Britta Baumann; Susanne Kohl; Eberhart Zrenner; Arne Lund Jorgensen; Bernd Wissinger

Tags: achromatopsia, cousin, mutation, phenotype, retinal cone

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4256-4262. doi:https://doi.org/10.1167/iovs.04-0317

A Novel Mutation in the ELOVL4 Gene Causes Autosomal Dominant Stargardt-like Macular Dystrophy Free

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Alessandra Maugeri; Francoise Meire; Carel B. Hoyng; Carolien Vink; Nicole Van Regemorter; Goutam Karan; Zhenglin Yang; Frans P. M. Cremers; Kang Zhang

Tags: genes, macular dystrophy, mutation, transfection, fusion proteins

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4263-4267. doi:https://doi.org/10.1167/iovs.04-0078

Clinical and Epidemiologic Research

Prevalence of Refractive Errors in a Rural South Indian Population Free

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Prema Raju; S. Ve Ramesh; Hemamalini Arvind; Ronnie George; Mani Baskaran; Pradeep G. Paul; Govindasamy Kumaramanickavel; Catherine McCarty; Lingam Vijaya

Tags: prevalence, refractive errors, myopia, hyperopia

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4268-4272. doi:https://doi.org/10.1167/iovs.04-0221

Female Reproductive Factors and Eye Disease in a Rural South Indian Population: The Aravind Comprehensive Eye Survey Free

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Praveen K. Nirmalan; Joanne Katz; Alan L. Robin; Rengappa Ramakrishnan; Ramasamy Krishnadas; Ravilla D. Thulasiraj; James M. Tielsch

Tags: eye, eye diseases, reproductive history, surveys, endogenous estrogens

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4273-4276. doi:https://doi.org/10.1167/iovs.04-0285

Cornea

Role of ErbB2 in Corneal Epithelial Wound Healing Free

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Ke-Ping Xu; April Riggs; Yu Ding; Fu-Shin X. Yu

Tags: cornea, epidermal growth factor receptors, epithelium, genes, erbb-2, receptor, erbb-2

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4277-4283. doi:https://doi.org/10.1167/iovs.04-0119

Modulation of Corneal Epithelial Cell Functions by the Neutrophil-Derived Inflammatory Mediator CAP37 Free

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H. Anne Pereira; Xin Ruan; Melva L. Gonzalez; Irina Tsyshevskaya-Hoover; James Chodosh

Tags: corneal epithelial cells, neutrophils, flow cytometry, cell adhesion molecules, chemotaxis

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4284-4292. doi:https://doi.org/10.1167/iovs.03-1052

Experimental Dry Eye Stimulates Production of Inflammatory Cytokines and MMP-9 and Activates MAPK Signaling Pathways on the Ocular Surface Free

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Lihui Luo; De-Quan Li; Amish Doshi; William Farley; Rosa M. Corrales; Stephen C. Pflugfelder

Tags: cytokine, dry eye syndromes, gelatinase b, mice, mitogen-activated protein kinases

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4293-4301. doi:https://doi.org/10.1167/iovs.03-1145

Stimulation of Matrix Metalloproteinases by Hyperosmolarity via a JNK Pathway in Human Corneal Epithelial Cells Free

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De-Quan Li; Zhuo Chen; Xiu Jun Song; Lihui Luo; Stephen C. Pflugfelder

Tags: corneal epithelial cells, doxycycline, gelatinase b, hyperosmolar hyperglycemia, matrix metalloproteinases

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4302-4311. doi:https://doi.org/10.1167/iovs.04-0299

Corneal Aberrations before and after Small-Incision Cataract Surgery Free

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Antonio Guirao; Jaime Tejedor; Pablo Artal

Tags: astigmatism, cataract surgery, cornea, surgical procedures, operative, coma

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4312-4319. doi:https://doi.org/10.1167/iovs.04-0693

Induction of Epithelial Progenitors In Vitro from Mouse Embryonic Stem Cells and Application for Reconstruction of Damaged Cornea in Mice Free

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Ryusuke Homma; Hideshi Yoshikawa; Mitsuhiro Takeno; Manae S. Kurokawa; Chieko Masuda; Erika Takada; Kazuo Tsubota; Satoki Ueno; Noboru Suzuki

Tags: cornea, embryonic stem cells, epithelium, mice, reconstructive surgical procedures

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4320-4326. doi:https://doi.org/10.1167/iovs.04-0044

Developmentally Regulated Expression of KLF6 in the Mouse Cornea and Lens Free

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Hiroshi Nakamura; Frédéric Chiambaretta; Joel Sugar; Vincent Sapin; Beatrice Y. J. T. Yue

Tags: cornea, lens (device), lens, crystalline, mice, embryo

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4327-4332. doi:https://doi.org/10.1167/iovs.04-0353

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Optotype and Grating Visual Acuity in Patients with Ocular and Cerebral Visual Impairment Free

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Peter Stiers; Ria Vanderkelen; Erik Vandenbussche

Tags: brain, visual acuity, visual impairment, child, cortical blindness

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4333-4339. doi:https://doi.org/10.1167/iovs.03-0822

Tissue Adhesives for a Sutureless Fadenoperation: An Experimental Study in a Rabbit Model Free

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Edward Tonelli, Jr; Henderson Celestino de Almeida; Eduardo Alves Bambirra

Tags: adhesives, experimental study, muscle, oryctolagus cuniculus, surgical procedures, operative

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4340-4345. doi:https://doi.org/10.1167/iovs.04-0049

Glaucoma

Prediction of Visual Field Progression in Glaucoma Free

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Kouros Nouri-Mahdavi; Douglas Hoffman; Douglas Gaasterland; Joseph Caprioli

Tags: follow-up, glaucoma, visual fields, linear regression, eye

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4346-4351. doi:https://doi.org/10.1167/iovs.04-0204

Regional Optic Nerve Damage in Experimental Mouse Glaucoma Free

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Fumihiko Mabuchi; Makoto Aihara; Mason R. Mackey; James D. Lindsey; Robert N. Weinreb

Tags: glaucoma, mice, optic nerve, axon, optic disk

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4352-4358. doi:https://doi.org/10.1167/iovs.04-0355

Variants in Optineurin Gene and Their Association with Tumor Necrosis Factor-α Polymorphisms in Japanese Patients with Glaucoma Free

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Tomoyo Funayama; Karin Ishikawa; Yuichiro Ohtake; Tomihiko Tanino; Daijiro Kurosaka; Itaru Kimura; Kotaro Suzuki; Hidenao Ideta; Kenji Nakamoto; Noriko Yasuda; Takuro Fujimaki; Akira Murakami; Ryo Asaoka; Yoshihiro Hotta; Hidenobu Tanihara; Takashi Kanamoto; Hiromu Mishima; Takeo Fukuchi; Haruki Abe; Takeshi Iwata; Naoki Shimada; Jun Kudoh; Nobuyoshi Shimizu; Yukihiko Mashima

Tags: genes, genotype determination, glaucoma, japanese, open-angle glaucoma

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4359-4367. doi:https://doi.org/10.1167/iovs.03-1403

Prostaglandin FP Agonists Alter Metalloproteinase Gene Expression in Sclera Free

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Robert N. Weinreb; James D. Lindsey; George Marchenko; Natalia Marchenko; Mila Angert; Alex Strongin

Tags: agonists, latanoprost, metalloproteases, polymerase chain reaction, prostaglandins

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4368-4377. doi:https://doi.org/10.1167/iovs.04-0413

Finite Element Modeling of Optic Nerve Head Biomechanics Free

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Ian A. Sigal; John G. Flanagan; Inka Tertinegg; C. Ross Ethier

Tags: biomechanics, intraocular pressure, optic disk, sclera, body tissue

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4378-4387. doi:https://doi.org/10.1167/iovs.04-0133

Three-Dimensional Reconstruction of Normal and Early Glaucoma Monkey Optic Nerve Head Connective Tissues Free

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Claude F. Burgoyne; J. Crawford Downs; Anthony J. Bellezza; Richard T. Hart

Tags: cercopithecidae, connective tissue, eye, glaucoma, optic disk

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4388-4399. doi:https://doi.org/10.1167/iovs.04-0022

Lens

Cl⁻ Influx into Rat Cortical Lens Fiber Cells Is Mediated by a Cl⁻ Conductance That Is Not ClC-2 or -3 Free

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Kevin F. Webb; B. Rachelle Merriman-Smith; Jonelle K. Stobie; Joerg Kistler; Paul J. Donaldson

Tags: lens (device), lens, crystalline

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4400-4408. doi:https://doi.org/10.1167/iovs.04-0205

Physiology and Pharmacology

Identification and Spatiotemporal Characterization of Spontaneous Ca²⁺ Sparks and Global Ca²⁺ Oscillations in Retinal Arteriolar Smooth Muscle Cells Free

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Tim M. Curtis; James Tumelty; Jennine Dawicki; C. Norman Scholfield; J. Graham McGeown

Tags: arteriole, myocytes, smooth muscle, diagnostic imaging, smooth muscle

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4409-4414. doi:https://doi.org/10.1167/iovs.04-0719

Intraocular Pressure in Zebrafish: Comparison of Inbred Strains and Identification of a Reduced Melanin Mutant with Raised IOP Free

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Brian A. Link; Matthew P. Gray; Richard S. Smith; Simon W. M. John

Tags: intraocular pressure, melanins, raised intraocular pressure, zebrafish, mammals

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4415-4422. doi:https://doi.org/10.1167/iovs.04-0557

Aquaporin-Dependent Water Permeation at the Mouse Ocular Surface: In Vivo Microfluorimetric Measurements in Cornea and Conjunctiva Free

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Marc H. Levin; A. S. Verkman

Tags: conjunctiva, cornea, mice, permeability, water

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4423-4432. doi:https://doi.org/10.1167/iovs.04-0816

Retina

A Homozygosity-Based Search for Mutations in Patients with Autosomal Recessive Retinitis Pigmentosa, Using Microsatellite Markers Free

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Hiroyuki Kondo; Minghui Qin; Atsushi Mizota; Mineo Kondo; Hideyuki Hayashi; Ken Hayashi; Kenji Oshima; Tomoko Tahira; Kenshi Hayashi

Tags: genes, homozygote, mutation, retinitis pigmentosa, microsatellite repeats

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4433-4439. doi:https://doi.org/10.1167/iovs.04-0544

Integration between Abutting Retinas: Role of Glial Structures and Associated Molecules at the Interface Free

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Yiqin Zhang; Agnieszka K. Kardaszewska; Theo van Veen; Uwe Rauch; Maria-Thereza R. Perez

Tags: molecule, retina, transplantation

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4440-4449. doi:https://doi.org/10.1167/iovs.04-0165

Microarray Analysis of the Failure of Filtering Blebs in a Rat Model of Glaucoma Filtering Surgery Free

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Douglas W. Esson; Michael P. Popp; Li Liu; Gregory S. Schultz; Mark B. Sherwood

Tags: blister, filtering surgery, gene expression, genes, glaucoma

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4450-4462. doi:https://doi.org/10.1167/iovs.04-0375

Focal Adhesion Kinase Overexpression Induces Enhanced Pathological Retinal Angiogenesis Free

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Lori J. Kornberg; Lynn C. Shaw; Polyxenie E. Spoerri; Sergio Caballero; Maria B. Grant

Tags: angiogenesis, endothelial cells, focal adhesions, phosphotransferases, protein overexpression

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4463-4469. doi:https://doi.org/10.1167/iovs.03-1201

Fundus Autofluorescence and Fundus Perimetry in the Junctional Zone of Geographic Atrophy in Patients with Age-Related Macular Degeneration Free

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Steffen Schmitz-Valckenberg; Stefan Bültmann; Jens Dreyhaupt; Almut Bindewald; Frank G. Holz; Klaus Rohrschneider

Tags: age-related macular degeneration, atrophy, fundus autofluorescence imaging, perimetry, eye

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4470-4476. doi:https://doi.org/10.1167/iovs.03-1311

Aquaporin-4 Gene Disruption in Mice Protects against Impaired Retinal Function and Cell Death after Ischemia Free

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Tong Da; A. S. Verkman

Tags: cell death, genes, ischemia, mice, water channels

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4477-4483. doi:https://doi.org/10.1167/iovs.04-0940

The Minnesota Grading System of Eye Bank Eyes for Age-Related Macular Degeneration Free

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Timothy W. Olsen; Xiao Feng

Tags: age-related macular degeneration, eye, eye banks, grading system, body tissue

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4484-4490. doi:https://doi.org/10.1167/iovs.04-0342

Stimulation of Neovascularization by the Anti-angiogenic Factor PEDF Free

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Rajendra S. Apte; Ramon A. Barreiro; Elia Duh; Olga Volpert; Thomas A. Ferguson

Tags: angiogenesis, choroidal neovascularization, endothelial cells, lasers, mice

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4491-4497. doi:https://doi.org/10.1167/iovs.04-0172

Genetic Linkage of Snowflake Vitreoretinal Degeneration to Chromosome 2q36 Free

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Xiaodong Jiao; Robert Ritter, III; J. Fielding Hejtmancik; Albert O. Edwards

Tags: chromosomes, genetic linkage, tissue degeneration, family, dna

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4498-4503. doi:https://doi.org/10.1167/iovs.04-0722

Differences in Pulsatile Ocular Blood Flow among Three Classifications of Diabetic Retinopathy Free

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Howard I. Savage; Jason W. Hendrix; David C. Peterson; Heather Young; Charles P. Wilkinson

Tags: diabetes mellitus, diabetic retinopathy, retinal diseases, vascular flow, nonproliferative diabetic retinopathy

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4504-4509. doi:https://doi.org/10.1167/iovs.04-0077

Contrast Sensitivity Deficits in Inferred Magnocellular and Parvocellular Pathways in Retinitis Pigmentosa Free

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Kenneth R. Alexander; Claire S. Barnes; Gerald A. Fishman; Joel Pokorny; Vivianne C. Smith

Tags: contrast sensitivity, retinitis pigmentosa, spatial frequency

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4510-4519. doi:https://doi.org/10.1167/iovs.04-0188

Iris Pigment Epithelium Attachment to Aged Submacular Human Bruch’s Membrane Free

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Hiroshi Itaya; Vamsi Gullapalli; Ilene K. Sugino; Makoto Tamai; Marco A. Zarbin

Tags: bruch's basal membrane, epithelium, interprofessional education, iris, pigment

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4520-4528. doi:https://doi.org/10.1167/iovs.04-0684

Taurine Uptake by Human Retinal Pigment Epithelium: Implications for the Transport of Small Solutes between the Choroid and the Outer Retina Free

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Jost Hillenkamp; Ali A. Hussain; Timothy L. Jackson; Joanna R. Cunningham; John Marshall

Tags: biological transport, choroid, taurine, retina, retinal pigment epithelium

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4529-4534. doi:https://doi.org/10.1167/iovs.04-0919

Retinal Cell Biology

Müller Cell Production of Insulin-like Growth Factor–Binding Proteins In Vitro: Modulation with Phenotype and Growth Factor Stimulation Free

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Jeffery L. King; Clyde Guidry

Tags: growth factor, insulin-like growth-factor-binding proteins, phenotype

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4535-4542. doi:https://doi.org/10.1167/iovs.04-0447

Retinopathy in Monkeys with Spontaneous Type 2 Diabetes Free

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Sahng Y. Kim; Mary A. Johnson; D. Scott McLeod; Theresa Alexander; Tsuyoshi Otsuji; Scott M. Steidl; Barbara C. Hansen; Gerard A. Lutty

Tags: cercopithecidae, diabetes mellitus, diabetes mellitus, type 2, hypertension, retina

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4543-4553. doi:https://doi.org/10.1167/iovs.04-0519

Expression of Class-3 Semaphorins and Their Receptors in the Neonatal and Adult Rat Retina Free

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Fred de Winter; Qi Cui; Natalie Symons; Joost Verhaagen; Alan R. Harvey

Tags: adult, retina, semaphorins, rna, messenger

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4554-4562. doi:https://doi.org/10.1167/iovs.04-0173

FAS-Mediated Apoptosis and Its Relation to Intrinsic Pathway Activation in an Experimental Model of Retinal Detachment Free

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David N. Zacks; Qiong-Duan Zheng; Ying Han; Rita Bakhru; Joan W. Miller

Tags: apoptosis, caspase-9, retinal detachment, tumor necrosis factor ligand superfamily member 6

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4563-4569. doi:https://doi.org/10.1167/iovs.04-0598

Otx2 Homeobox Gene Induces Photoreceptor-Specific Phenotypes in Cells Derived from Adult Iris and Ciliary Tissue Free

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Tadamichi Akagi; Michiko Mandai; Sotaro Ooto; Yasuhiko Hirami; Fumitaka Osakada; Ryoichiro Kageyama; Nagahisa Yoshimura; Masayo Takahashi

Tags: adult, body tissue, immune reconstitution inflammatory syndrome, iris, phenotype

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4570-4575. doi:https://doi.org/10.1167/iovs.04-0697

Susceptibilities to and Mechanisms of Excitotoxic Cell Death of Adult Mouse Inner Retinal Neurons in Dissociated Culture Free

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Xianmin Luo; Akemichi Baba; Toshio Matsuda; Carmelo Romano

Tags: adult, agonists, cell death, mice, neurons

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4576-4582. doi:https://doi.org/10.1167/iovs.04-0166

Involvement of Protein Kinase CK2 in Angiogenesis and Retinal Neovascularization Free

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Alexander V. Ljubimov; Sergio Caballero; Annette M. Aoki; Lorenzo A. Pinna; Maria B. Grant; Raquel Castellon

Tags: angiogenesis, growth factor, protein kinase, retinal neovascularization, emodin

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4583-4591. doi:https://doi.org/10.1167/iovs.04-0686

Visual Neuroscience

Paired-Flash Identification of Rod and Cone Dysfunction in the Diabetic Rat Free

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Joanna A. Phipps; Erica L. Fletcher; Algis J. Vingrys

Tags: diabetes mellitus, pathophysiology, retinal cone, rod photoreceptors, streptozocin

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4592-4600. doi:https://doi.org/10.1167/iovs.04-0842

Visual Psychophysics and Physiological Optics

Adaptive Optics Simulation of Intraocular Lenses with Modified Spherical Aberration Free

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Patricia A. Piers; Enrique J. Fernandez; Silvestre Manzanera; Sverker Norrby; Pablo Artal

Tags: contrast sensitivity, intraocular lens implant device, optics, green light, eye

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4601-4610. doi:https://doi.org/10.1167/iovs.04-0234

Rapid Quantification of Adult and Developing Mouse Spatial Vision Using a Virtual Optomotor System Free

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Glen T. Prusky; Nazia M. Alam; Steven Beekman; Robert M. Douglas

Tags: adult, mice, spatial vision, visual thresholds

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4611-4616. doi:https://doi.org/10.1167/iovs.04-0541

Index

Thank You to Reviewers Free

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Tags: betula, calculi, christianity, neurobehavioral disorder associated with prenatal alcohol exposure, potassium hydroxide

Investigative Ophthalmology & Visual Science December 2004, Vol.45, 4617-4622. doi:

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