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Anatomy and Pathology/Oncology

The Response to Visual Form Deprivation Differs with Age in Marmosets Free
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David Troilo; Debora L. Nickla
Tags: callithrix, cornea, eye, myopia, vitreous body
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 1873-1881. doi:https://doi.org/10.1167/iovs.04-1422

Biochemistry and Molecular Biology

Identification of Novel Murine- and Human-Specific RPGRIP1 Splice Variants with Distinct Expression Profiles and Subcellular Localization Free
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Xinrong Lu; Paulo A. Ferreira
Tags: protein isoforms, retina, antibodies, exons, body tissue
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 1882-1890. doi:https://doi.org/10.1167/iovs.04-1286
Identification of Novel RPGR ORF15 Mutations in X-linked Progressive Cone-Rod Dystrophy (XLCORD) Families Free
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Neil D. Ebenezer; Michel Michaelides; Sharon A. Jenkins; Isabelle Audo; Andrew R. Webster; Michael E. Cheetham; Andrew Stockman; Eamonn R. Maher; John R. Ainsworth; John R. Yates; Keith Bradshaw; Graham E. Holder; Anthony T. Moore; Alison J. Hardcastle
Tags: family, mutation, progressive cone-rod dystrophy, x-linked inheritance, retinitis pigmentosa
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 1891-1898. doi:https://doi.org/10.1167/iovs.04-1482

Clinical and Epidemiologic Research

Corneal Asphericity and Apical Curvature in Children: A Cross-sectional and Longitudinal Evaluation Free
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William R. Davis; Thomas W. Raasch; G. Lynn Mitchell; Donald O. Mutti; Karla Zadnik
Tags: child, cornea, refractive errors, anterior chamber of eye
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 1899-1906. doi:https://doi.org/10.1167/iovs.04-0558
The 5-Year Incidence and Risk Factors for Age-Related Maculopathy in a General Japanese Population: The Hisayama Study Free
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Miho Miyazaki; Yutaka Kiyohara; Ayako Yoshida; Mitsuo Iida; Yoshiaki Nose; Tatsuro Ishibashi
Tags: age-related macular degeneration, incidence, japanese, risk factors, smoking
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 1907-1910. doi:https://doi.org/10.1167/iovs.04-0923
Self-Reported Dry Eye Disease across Refractive Modalities Free
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Jason J. Nichols; Corrie Ziegler; G. Lynn Mitchell; Kelly K. Nichols
Tags: dry eye syndromes, self-report, contact lenses, signs and symptoms, gender
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 1911-1914. doi:https://doi.org/10.1167/iovs.04-1294

Cornea

Accuracy of Zernike Polynomials in Characterizing Optical Aberrations and the Corneal Surface of the Eye Free
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Luis Alberto Carvalho
Tags: cornea, eye, optics
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 1915-1926. doi:https://doi.org/10.1167/iovs.04-1222
LPA and S1P Increase Corneal Epithelial and Endothelial Cell Transcellular Resistance Free
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Fei Yin; Mitchell A. Watsky
Tags: cornea, endothelial cells, endothelium, epithelium, actins
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 1927-1933. doi:https://doi.org/10.1167/iovs.04-1256
Inheritance of a Novel COL8A2 Mutation Defines a Distinct Early-Onset Subtype of Fuchs Corneal Dystrophy Free
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John D. Gottsch; Olof H. Sundin; Sammy H. Liu; Albert S. Jun; Karl W. Broman; Walter J. Stark; Elizabeth C. L. Vito; Amol K. Narang; John M. Thompson; Malcolm Magovern
Tags: family, genetic inheritance, hereditary corneal dystrophy, mutation, cornea
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 1934-1939. doi:https://doi.org/10.1167/iovs.04-0937
Increased Expression of Inflammatory Cytokines and Matrix Metalloproteinases in Pseudophakic Corneal Edema Free
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Yochai Shoshani; Jacob Pe’er; Victoria Doviner; Joseph Frucht-Pery; Abraham Solomon
Tags: cornea, corneal edema, cytokine, matrix metalloproteinases, tumor necrosis factors
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 1940-1947. doi:https://doi.org/10.1167/iovs.04-1203
Changes in Collagen Orientation and Distribution in Keratoconus Corneas Free
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Keith M. Meek; Stephen J. Tuft; Yifei Huang; Paulvinder S. Gill; Sally Hayes; Richard H. Newton; Anthony J. Bron
Tags: collagen, cornea, diagnostic radiologic examination, keratoconus, roentgen rays
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 1948-1956. doi:https://doi.org/10.1167/iovs.04-1253
In Vivo and In Vitro Expression of Connexins in the Human Corneal Epithelium Free
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Daniel L. Shurman; Lisa Glazewski; Anna Gumpert; James D. Zieske; Gabriele Richard
Tags: corneal epithelium, gap junction protein, calcium
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 1957-1965. doi:https://doi.org/10.1167/iovs.04-1364
Characterization of Tetracycline-Inducible Bitransgenic Krt12rtTA/+/tet-O-LacZ Mice Free
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Tai-ichiro Chikama; Yasuhito Hayashi; Chia-Yang Liu; Noriko Terai; Kazuto Terai; Candace W.-C. Kao; Li Wang; Miyuki Hayashi; Teruo Nishida; Philip Sanford; Tom Doestchman; Winston W.-Y. Kao
Tags: doxycycline, galactosidase, mice, tetracycline, cornea
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 1966-1972. doi:https://doi.org/10.1167/iovs.04-1464

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Atypical Composition and Ultrastructure of Proteoglycans in the Mouse Corneal Stroma Free
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Robert D. Young; Debbie Tudor; Anthony J. Hayes; Briedgeen Kerr; Yasutaka Hayashida; Kohji Nishida; Keith M. Meek; Bruce Caterson; Andrew J. Quantock
Tags: atypical, cornea, corneal stroma, mice, phosphatidylglycerols
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 1973-1978. doi:https://doi.org/10.1167/iovs.04-1309
Eye Movements in Chorea-Acanthocytosis Free
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Libe Gradstein; Adrian Danek; Jordan Grafman; Edmond J. FitzGibbon
Tags: chorea acanthocytosis syndrome, eye movement, saccades, velocity, eye
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 1979-1987. doi:https://doi.org/10.1167/iovs.04-0539

Glaucoma

CB2 Cannabinoid Receptors in Trabecular Meshwork Cells Mediate JWH015-Induced Enhancement of Aqueous Humor Outflow Facility Free
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Lichun Zhong; Lijun Geng; YaFatou Njie; Wenke Feng; Zhao-Hui Song
Tags: aqueous humor, cannabinoid receptors, suidae, trabecular meshwork, mitogen-activated protein kinases
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 1988-1992. doi:https://doi.org/10.1167/iovs.04-0651
Genetic Polymorphisms in the Angiotensin II Receptor Gene and Their Association with Open-Angle Glaucoma in a Japanese Population Free
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Kouhei Hashizume; Yukihiko Mashima; Tomoyo Fumayama; Yuichiro Ohtake; Itaru Kimura; Kazuhide Yoshida; Karin Ishikawa; Noriko Yasuda; Takuro Fujimaki; Ryo Asaoka; Takahisa Koga; Takashi Kanamoto; Takeo Fukuchi; Koichi Miyaki
Tags: genes, genotype, glaucoma, intraocular pressure, japanese
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 1993-2001. doi:https://doi.org/10.1167/iovs.04-1100
Early Adult-Onset POAG Linked to 15q11-13 Using Ordered Subset Analysis Free
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R. Rand Allingham; Janey L. Wiggs; Elizabeth R. Hauser; Karen R. Larocque-Abramson; Cecilia Santiago-Turla; Bob Broomer; Elizabeth A. Del Bono; Felicia L. Graham; Jonathan L. Haines; Margaret A. Pericak-Vance; Michael A. Hauser
Tags: adult, family, open-angle glaucoma
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2002-2005. doi:https://doi.org/10.1167/iovs.04-1477
Prostaglandin Analogues and Mouse Intraocular Pressure: Effects of Tafluprost, Latanoprost, Travoprost, and Unoprostone, Considering 24-Hour Variation Free
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Takashi Ota; Hiroshi Murata; Ei-ichiro Sugimoto; Makoto Aihara; Makoto Araie
Tags: intraocular pressure, latanoprost, mice, prostaglandins, synthetic, tafluprost
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2006-2011. doi:https://doi.org/10.1167/iovs.04-1527
Macular Segmentation with Optical Coherence Tomography Free
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Hiroshi Ishikawa; Daniel M. Stein; Gadi Wollstein; Siobahn Beaton; James G. Fujimoto; Joel S. Schuman
Tags: eye, glaucoma, optical coherence tomography, image quality
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2012-2017. doi:https://doi.org/10.1167/iovs.04-0335
Prolonged Antiscarring Effects of Ilomastat and MMC after Experimental Glaucoma Filtration Surgery Free
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Tina T. L. Wong; Anna L. Mead; Peng T. Khaw
Tags: blister, filtering surgery, glaucoma, postoperative care, cicatrix
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2018-2022. doi:https://doi.org/10.1167/iovs.04-0820
Selective Upregulation of the A3 Adenosine Receptor in Eyes with Pseudoexfoliation Syndrome and Glaucoma Free
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Ursula Schlötzer-Schrehardt; Matthias Zenkel; Ulrich Decking; Daniela Haubs; Friedrich E. Kruse; Anselm Jünemann; Miguel Coca-Prados; Gottfried O. H. Naumann
Tags: adenosine, adenosine receptors, eye, glaucoma, up-regulation (physiology)
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2023-2034. doi:https://doi.org/10.1167/iovs.04-0915
Activation of the Epidermal Growth Factor Receptor in Optic Nerve Astrocytes Leads to Early and Transient Induction of Cyclooxygenase-2 Free
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Xu Zhang; Arthur H. Neufeld
Tags: astrocytes, cyclooxygenase-2, cyclooxygenase-2 inhibitors, epidermal growth factor receptors, optic nerve
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2035-2041. doi:https://doi.org/10.1167/iovs.04-1473

Immunology and Microbiology

Bacterial Transmission from Contact Lenses to Porcine Corneas: An Ex Vivo Study Free
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Pit B. J. Vermeltfoort; Theo G. van Kooten; Gerda M. Bruinsma; Anneke M. M. Hooymans; Henny C. van der Mei; Henk J. Busscher
Tags: capillary leak syndrome, contact lenses, cornea, de lange syndrome, suidae
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2042-2046. doi:https://doi.org/10.1167/iovs.04-1401
Infection of Retinal Neurons during Murine Cytomegalovirus Retinitis Free
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Ming Zhang; Hua Xin; Penny Roon; Sally S. Atherton
Tags: cytomegalovirus retinitis, eye, gamma-aminobutyric acid, glial fibrillary acidic protein, infections
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2047-2055. doi:https://doi.org/10.1167/iovs.05-0005
Administration of a Peptide Inhibitor of α4-Integrin Inhibits the Development of Experimental Autoimmune Uveitis Free
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Andrea P. Martín; Luciana Vieira de Moraes; Carlos E. Tadokoro; Alessandra G. Commodaro; Enrique Urrets-Zavalia; Gabriel A. Rabinovich; Julio Urrets-Zavalia; Luiz V. Rizzo; Horacio M. Serra
Tags: autoimmune diseases, autoimmunity, integrins, peptides, uveitis
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2056-2063. doi:https://doi.org/10.1167/iovs.04-0418
Effects of Toxin Production in a Murine Model of Staphylococcus aureus Keratitis Free
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Dalia O. Girgis; Gregory D. Sloop; Julian M. Reed; Richard J. O’Callaghan
Tags: eye, keratitis, mice, toxins, infections
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2064-2070. doi:https://doi.org/10.1167/iovs.04-0897

Lens

Impairment of Visual Acuity and Reading Performance and the Relationship with Cataract Type and Density Free
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Eva Stifter; Stefan Sacu; Thomas Benesch; Herbert Weghaupt
Tags: cataract, reading (activity), visual acuity, impairment
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2071-2075. doi:https://doi.org/10.1167/iovs.04-0890
Studies of Tyrosine Phosphorylation and Src Family Tyrosine Kinases in the Lens Epithelium Free
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Shigeo Tamiya; Nicholas A. Delamere
Tags: lens epithelium, phosphorylation, phosphotransferases, src-family kinases, tyrosine
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2076-2081. doi:https://doi.org/10.1167/iovs.04-1199
Upregulation of Heat Shock Protein Expression by Proteasome Inhibition: An Antiapoptotic Mechanism in the Lens Free
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Niranjan Awasthi; B. J. Wagner
Tags: antiapoptotic agents, heat-shock proteins, multicatalytic endopeptidase complex, proteasome inhibitors, lens, crystalline
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2082-2091. doi:https://doi.org/10.1167/iovs.05-0002
Curcumin and Turmeric Delay Streptozotocin-Induced Diabetic Cataract in Rats Free
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Palla Suryanarayana; Megha Saraswat; Tiruvalluru Mrudula; T. Prasanna Krishna; Kamala Krishnaswamy; G. Bhanuprakash Reddy
Tags: cataract, curcumin, diabetic cataract, rats, streptozocin
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2092-2099. doi:https://doi.org/10.1167/iovs.04-1304
Mutations in βB3-Crystallin Associated with Autosomal Recessive Cataract in Two Pakistani Families Free
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S. Amer Riazuddin; Afshan Yasmeen; Wenliang Yao; Yuri V. Sergeev; Qingjiong Zhang; Fareeha Zulfiqar; Assad Riaz; Sheikh Riazuddin; J. Fielding Hejtmancik
Tags: autosomal recessive inheritance, cataract, crystallins, family, mutation
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2100-2106. doi:https://doi.org/10.1167/iovs.04-1481
Methionine Sulfoxide Reductases B1, B2, and B3 Are Present in the Human Lens and Confer Oxidative Stress Resistance to Lens Cells Free
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Maria A. Marchetti; Gresin O. Pizarro; Daphna Sagher; Candida DeAmicis; Nathan Brot; J. Fielding Hejtmancik; Herbert Weissbach; Marc Kantorow
Tags: lens (device), lens cell, lens, crystalline, methionine, oxidative stress
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2107-2112. doi:https://doi.org/10.1167/iovs.05-0018

Physiology and Pharmacology

Requisite Roles of A2A Receptors, Nitric Oxide, and KATP Channels in Retinal Arteriolar Dilation in Response to Adenosine Free
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Travis W. Hein; Zhaoxu Yuan; Robert H. Rosa, Jr; Lih Kuo
Tags: adenosine, dilatation, pathologic, nitric oxide, arteriole
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2113-2119. doi:https://doi.org/10.1167/iovs.04-1438

Retina

In Vitro Multispectral Diffuse Reflectance Measurements of the Porcine Fundus Free
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David A. Salyer; Karen Twietmeyer; Neil Beaudry; Sreenivasa Basavanthappa; Robert I. Park; Russell Chipman
Tags: eye, light, lighting, suidae
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2120-2124. doi:https://doi.org/10.1167/iovs.04-1020
Intravitreous Injection of a Membrane Depolarization Agent Causes Retinal Degeneration Via Matrix Metalloproteinase-9 Free
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Raghuveer S. Mali; Mei Cheng; Shravan K. Chintala
Tags: depolarization, gelatinase b, intravitreal injections, potassium chloride, retinal degeneration
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2125-2132. doi:https://doi.org/10.1167/iovs.04-1376
Activation of the Mitochondrial Apoptotic Pathway in a Rat Model of Central Retinal Artery Occlusion Free
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Yi Zhang; Chang-Ho Cho; La-ongsri Atchaneeyasakul; Trevor McFarland; Binoy Appukuttan; J. Timothy Stout
Tags: central retinal artery occlusion, mitochondria, ischemia, cytochrome c, cytosol
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2133-2139. doi:https://doi.org/10.1167/iovs.04-1235
φC31 Integrase Confers Genomic Integration and Long-Term Transgene Expression in Rat Retina Free
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Thomas W. Chalberg; Hilary L. Genise; Douglas Vollrath; Michele P. Calos
Tags: dna, genome, integrase, retina, transgenes
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2140-2146. doi:https://doi.org/10.1167/iovs.04-1252
Transcorneal Electrical Stimulation Rescues Axotomized Retinal Ganglion Cells by Activating Endogenous Retinal IGF-1 System Free
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Takeshi Morimoto; Tomomitsu Miyoshi; Satoshi Matsuda; Yasuo Tano; Takashi Fujikado; Yutaka Fukuda
Tags: insulin-like growth factor i, electric stimulation, retina
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2147-2155. doi:https://doi.org/10.1167/iovs.04-1339
Cone-like Morphological, Molecular, and Electrophysiological Features of the Photoreceptors of the Nrl Knockout Mouse Free
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Lauren L. Daniele; Concepcion Lillo; Arkady L. Lyubarsky; Sergei S. Nikonov; Nancy Philp; Alan J. Mears; Anand Swaroop; David S. Williams; Edward N. Pugh, Jr
Tags: photoreceptors, retinal cone, mice, retina
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2156-2167. doi:https://doi.org/10.1167/iovs.04-1427
Anastomotic Vessels Remain Viable after Photodynamic Therapy in Primate Models of Choroidal Neovascularization Free
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Mark H. Criswell; Thomas A. Ciulla; Lisa A. Lowseth; Ward Small; Ronald P. Danis; Dennis L. Carson
Tags: anastomosis, surgical, choroidal neovascularization, lasers, light coagulation, photochemotherapy
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2168-2174. doi:https://doi.org/10.1167/iovs.04-1442

Retinal Cell Biology

Soluble Forms of EphrinB2 and EphB4 Reduce Retinal Neovascularization in a Model of Proliferative Retinopathy Free
PDF
David O. Zamora; Michael H. Davies; Stephen R. Planck; James T. Rosenbaum; Michael R. Powers
Tags: diabetic retinopathy, ephrins, hyperoxia, mice, oxygen
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2175-2182. doi:https://doi.org/10.1167/iovs.04-0983
Stimulation of P2X7 Receptors Elevates Ca2+ and Kills Retinal Ganglion Cells Free
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Xiulan Zhang; Mei Zhang; Alan M. Laties; Claire H. Mitchell
Tags: cell death, ganglia, killing, retinal ganglion cells, agonists
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2183-2191. doi:https://doi.org/10.1167/iovs.05-0052
MPP5 Recruits MPP4 to the CRB1 Complex in Photoreceptors Free
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Albena Kantardzhieva; Ilse Gosens; Svetlana Alexeeva; Ingrid M. Punte; Inge Versteeg; Elmar Krieger; Carla A. Neefjes-Mol; Anneke I. den Hollander; Stef J. F. Letteboer; Jan Klooster; Frans P. M. Cremers; Ronald Roepman; Jan Wijnholds
Tags: photoreceptors, proteins, retina, mice, yeast one/two-hybrid system
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2192-2201. doi:https://doi.org/10.1167/iovs.04-1417
Embryonic Synthesis of the Inner Limiting Membrane and Vitreous Body Free
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Willi Halfter; Sucai Dong; Barbara Schurer; Colleen Ring; Gregory J. Cole; Andrew Eller
Tags: embryo, eye, proteins, rna, messenger, vitreous body
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2202-2209. doi:https://doi.org/10.1167/iovs.04-1419
The Ins2Akita Mouse as a Model of Early Retinal Complications in Diabetes Free
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Alistair J. Barber; David A. Antonetti; Timothy S. Kern; Chad E. N. Reiter; Rohit S. Soans; J. Kyle Krady; Steven W. Levison; Thomas W. Gardner; Sarah K. Bronson
Tags: diabetes mellitus, diabetes mellitus, type 2, mice, retina, hyperglycemia
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2210-2218. doi:https://doi.org/10.1167/iovs.04-1340

Visual Psychophysics and Physiological Optics

Spatial Frequency Sensitivity Differences between Adults of Good and Poor Reading Ability Free
PDF
Geoffrey R. Patching; Timothy R. Jordan
Tags: adult, reading ability, spatial frequency, visual acuity
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2219-2224. doi:https://doi.org/10.1167/iovs.03-1247
Improving the Design of the Letter Contrast Sensitivity Test Free
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Aries Arditi
Tags: contrast sensitivity test
Investigative Ophthalmology & Visual Science June 2005, Vol.46, 2225-2229. doi:https://doi.org/10.1167/iovs.04-1198
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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