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Anatomy and Pathology/Oncology

Subconjunctival Topotecan in Fibrin Sealant in the Treatment of Transgenic Murine Retinoblastoma Free
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Janet Y. Tsui; Clifton Dalgard; Kurtis R. Van Quill; Linda Lee; Hans E. Grossniklaus; Henry F. Edelhauser; Joan M. O'Brien
Tags: animals, transgenic, eye, fibrin tissue adhesive, neoplasms, retinoblastoma
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 490-496. doi:https://doi.org/10.1167/iovs.07-0653
Involvement of PI3K/Akt Signaling Pathway in Hepatocyte Growth Factor–Induced Migration of Uveal Melanoma Cells Free
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Mao Ye; Danning Hu; Lili Tu; Xiangtian Zhou; Fan Lu; Bin Wen; Wencan Wu; Yi Lin; Zhonglou Zhou; Jia Qu
Tags: 1-phosphatidylinositol 3-kinase, akt signaling pathway, hepatocyte growth factor, met gene, proto-oncogene proteins c-akt
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 497-504. doi:https://doi.org/10.1167/iovs.07-0975
Monosomy of Chromosome 3 and an Inflammatory Phenotype Occur Together in Uveal Melanoma Free
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Willem Maat; Long V. Ly; Ekaterina S. Jordanova; Didi de Wolff-Rouendaal; Nicoline E. Schalij-Delfos; Martine J. Jager
Tags: chromosomes, human, pair 3, monosomy, phenotype, uveal melanoma, neoplasms
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 505-510. doi:https://doi.org/10.1167/iovs.07-0786

Biochemistry and Molecular Biology

Expression Profiling after Retinal Detachment and Reattachment: A Possible Role for Aquaporin-0 Free
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Rafal Farjo; Ward M. Peterson; Muna I. Naash
Tags: gene expression profiling, genes, mice, molecular profiling, retina
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 511-521. doi:https://doi.org/10.1167/iovs.07-1013
Interaction between Bevacizumab and Murine VEGF-A: A Reassessment Free
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Lanlan Yu; Xiumin Wu; Zhiyong Cheng; Chingwei V. Lee; Jennifer LeCouter; Claudio Campa; Germaine Fuh; Henry Lowman; Napoleone Ferrara
Tags: bevacizumab, vascular endothelial growth factor a, monoclonal antibodies
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 522-527. doi:https://doi.org/10.1167/iovs.07-1175

Clinical and Epidemiologic Research

Visual Impairment, Causes of Vision Loss, and Falls: The Singapore Malay Eye Study Free
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Ecosse L. Lamoreux; Elaine Chong; Jie Jin Wang; Seang Mei Saw; Tin Aung; Paul Mitchell; Tien Yin Wong
Tags: blindness, eye, singapore, visual impairment
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 528-533. doi:https://doi.org/10.1167/iovs.07-1036
The Role of Educational Attainment in Refraction: The Genes in Myopia (GEM) Twin Study Free
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Mohamed Dirani; Sri N. Shekar; Paul N. Baird
Tags: educational status, myopia, refraction, twin studies, genes
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 534-538. doi:https://doi.org/10.1167/iovs.07-1123

Cornea

Hyperosmolarity-Induced Cornification of Human Corneal Epithelial Cells Is Regulated by JNK MAPK Free
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Zhuo Chen; Louis Tong; Zhijie Li; Kyung-Chul Yoon; Hong Qi; William Farley; De-Quan Li; Stephen C. Pflugfelder
Tags: corneal epithelial cells, keratinization, mitogen-activated protein kinases, mosmol, osmosis
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 539-549. doi:https://doi.org/10.1167/iovs.07-0569
Use of Poloxamers for Deswelling of Organ-Cultured Corneas Free
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Min Zhao; Gilles Thuret; Simone Piselli; Aurelien Pipparelli; Sophie Acquart; Michel Peoc’h; Jean-Marc Dumollard; Philippe Gain
Tags: cornea, dextran, endothelium, poloxamer, histology
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 550-559. doi:https://doi.org/10.1167/iovs.07-1037
Corneal Involvement in Rheumatoid Arthritis: An In Vivo Confocal Study Free
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Edoardo Villani; Daniela Galimberti; Francesco Viola; Chiara Mapelli; Nicoletta Del Papa; Roberto Ratiglia
Tags: cornea, rheumatoid arthritis, microscopy, confocal
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 560-564. doi:https://doi.org/10.1167/iovs.07-0893
Delayed Disruption of Barrier Function in Cultured Human Corneal Epithelial Cells Induced by Tumor Necrosis Factor-α in a Manner Dependent on NF-κB Free
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Kazuhiro Kimura; Shinichiro Teranishi; Ken Fukuda; Koji Kawamoto; Teruo Nishida
Tags: corneal epithelial cells, curcumin, immunoblotting, tumor necrosis, tumor necrosis factors
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 565-571. doi:https://doi.org/10.1167/iovs.07-0419

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Frequency and Severity of Visual Sensory and Motor Deficits in Children with Cerebral Palsy: Gross Motor Function Classification Scale Free
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Fatema Ghasia; Janice Brunstrom; Mae Gordon; Lawrence Tychsen
Tags: cerebral palsy, child, motor deficits, motor function, strabismus
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 572-580. doi:https://doi.org/10.1167/iovs.07-0525
Horizontal and Vertical Look and Stare Optokinetic Nystagmus Symmetry in Healthy Adult Volunteers Free
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Christopher M. Knapp; Irene Gottlob; Rebecca J. McLean; Frank A. Proudlock
Tags: adult, eye, nystagmus, optokinetic, voluntary workers, velocity
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 581-588. doi:https://doi.org/10.1167/iovs.07-0773
The Effect of Aging on Torsional Optokinetic Nystagmus Free
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Shegufta J. Farooq; Irene Gottlob; Sherwin Benskin; Frank A. Proudlock
Tags: aging, eye movement, nystagmus, optokinetic, velocity, eye
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 589-593. doi:https://doi.org/10.1167/iovs.07-0899
The Effect of Amblyopia on Fine Motor Skills in Children Free
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Ann L. Webber; Joanne M. Wood; Glen A. Gole; Brian Brown
Tags: amblyopia, child, fine motor skills, strabismus
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 594-603. doi:https://doi.org/10.1167/iovs.07-0869
Saccade Dynamics before, during, and after Saccadic Adaptation in Humans Free
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Thérèse Collins; Arslan Semroud; Eric Orriols; Karine Doré-Mazars
Tags: saccades, velocity, deceleration
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 604-612. doi:https://doi.org/10.1167/iovs.07-0753

Glaucoma

Dependency of Intraocular Pressure Elevation and Glaucomatous Changes in DBA/2J and DBA/2J-Rj Mice Free
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Michael Scholz; Thomas Buder; Silke Seeber; Edyta Adamek; Cord-Michael Becker; Elke Lütjen-Drecoll
Tags: eye, glaucoma, intraocular pressure, mice
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 613-621. doi:https://doi.org/10.1167/iovs.07-0745
Tissue Transglutaminase Expression and Activity in Normal and Glaucomatous Human Trabecular Meshwork Cells and Tissues Free
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Tara Tovar-Vidales; Rouel Roque; Abbot F. Clark; Robert J. Wordinger
Tags: body tissue, glaucoma, proteins, transglutaminases, trabecular meshwork
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 622-628. doi:https://doi.org/10.1167/iovs.07-0835
Response of Human Trabecular Meshwork Cells to Topographic Cues on the Nanoscale Level Free
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Paul Russell; Joshua Z. Gasiorowski; Paul F. Nealy; Christopher J. Murphy
Tags: cues, dexamethasone, rna, messenger, trabecular meshwork, myoc gene
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 629-635. doi:https://doi.org/10.1167/iovs.07-1192

Immunology and Microbiology

Differential Expression of Chemokine Receptors on Uveal Melanoma Cells and Their Metastases Free
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Haochuan Li; Hassan Alizadeh; Jerry Y. Niederkorn
Tags: chemokine receptors, cxcr4 receptors, neoplasm metastasis, uveal melanoma, liver
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 636-643. doi:https://doi.org/10.1167/iovs.07-1035
Developmental Changes in Conjunctiva-Associated Lymphoid Tissue of the Rabbit Free
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Charlette Cain; Thomas E. Phillips
Tags: conjunctiva, hair follicle, latex, lymphoid tissue, oryctolagus cuniculus
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 644-649. doi:https://doi.org/10.1167/iovs.07-0856

Lens

TGFβ-Induced Contraction Is Not Promoted by Fibronectin-Fibronectin Receptor Interaction, or αSMA Expression Free
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Lucy Jean Dawes; Julie Ann Eldred; Ian Kevin Anderson; Matthew Sleeman; John R. Reddan; George Duncan; Ian Michael Wormstone
Tags: fibronectins, proteins, rna, small interfering, gene expression, integrins
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 650-661. doi:https://doi.org/10.1167/iovs.07-0586

Physiology and Pharmacology

Simultaneous but Not Prior Inhibition of VEGF165 Enhances the Efficacy of Photodynamic Therapy in Multiple Models of Ocular Neovascularization Free
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Meihua Ju; Carolina Mailhos; John Bradley; Tracy Dowie; Mary Ganley; Gary Cook; Perry Calias; Norbert Lange; Anthony P. Adamis; David T. Shima; Gregory S. Robinson
Tags: cornea, neovascularization, pathologic, pegaptanib, photochemotherapy, sodium
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 662-670. doi:https://doi.org/10.1167/iovs.07-0195
Protection against Oxidant-Induced Apoptosis by Exogenous Glutathione in Leber Hereditary Optic Neuropathy Cybrids Free
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Anna Ghelli; Anna Maria Porcelli; Claudia Zanna; Andrea Martinuzzi; Valerio Carelli; Michela Rugolo
Tags: glutathione, optic atrophy, hereditary, leber, oxidants, rotenone, apoptosis
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 671-676. doi:https://doi.org/10.1167/iovs.07-0880
Activation of Store-Operated Ca2+ Channels in Trabecular Meshwork Cells Free
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Elena Abad; Gisela Lorente; Núria Gavara; Miguel Morales; Arcadi Gual; Xavier Gasull
Tags: endothelin-1, trabecular meshwork, agonists, calcium, egtazic acid
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 677-686. doi:https://doi.org/10.1167/iovs.07-1080

Retina

Impact of Diabetic Retinopathy on Quantitative Retinal Nerve Fiber Layer Measurement and Glaucoma Screening Free
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Hirokazu Takahashi; Etsuo Chihara
Tags: diabetes mellitus, diabetic retinopathy, eye, glaucoma, glaucoma screening
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 687-692. doi:https://doi.org/10.1167/iovs.07-0655
Interleukin Gene Polymorphisms in Age-Related Macular Degeneration Free
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Yi-Yu Tsai; Jane-Ming Lin; Lei Wan; Hui-Ju Lin; Yushin Tsai; Cheng-Chun Lee; Chang-Hai Tsai; Fuu-Jen Tsai; Sung-Huei Tseng
Tags: age-related macular degeneration, genes, interleukin-8, interleukins, polymorphism
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 693-698. doi:https://doi.org/10.1167/iovs.07-0125
Retinal Arteriolar Hemodynamic Response to a Combined Isocapnic Hyperoxia and Glucose Provocation in Early Sight-Threatening Diabetic Retinopathy Free
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Edward D. Gilmore; Chris Hudson; Ravi K. Nrusimhadevara; Rowena Ridout; Patricia T. Harvey; Mark Mandelcorn; Wai-Ching Lam; Robert G. Devenyi
Tags: diabetic retinopathy, glucose, hyperoxia, hemodynamics, vision
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 699-705. doi:https://doi.org/10.1167/iovs.07-0339
High Susceptibility to Experimental Myopia in a Mouse Model with a Retinal ON Pathway Defect Free
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Machelle T. Pardue; Amanda E. Faulkner; Alcides Fernandes; Hang Yin; Frank Schaeffel; Robert W. Williams; Nikita Pozdeyev; P. Michael Iuvone
Tags: disease susceptibility, mice, myopia, refractive errors, eye
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 706-712. doi:https://doi.org/10.1167/iovs.07-0643
Intrinsic Signals from Human Cone Photoreceptors Free
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Kate Grieve; Austin Roorda
Tags: diagnostic imaging, retinal cone, noise, retina
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 713-719. doi:https://doi.org/10.1167/iovs.07-0837
Sildenafil (Viagra) Evokes Retinal Arteriolar Dilation: Dual Pathways via NOS Activation and Phosphodiesterase Inhibition Free
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Zhaoxu Yuan; Travis W. Hein; Robert H. Rosa, Jr; Lih Kuo
Tags: dilatation, pathologic, phosphoric diester hydrolase, sildenafil, arteriole
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 720-725. doi:https://doi.org/10.1167/iovs.07-1208
Characterization of Azurocidin as a Permeability Factor in the Retina: Involvement in VEGF-Induced and Early Diabetic Blood-Retinal Barrier Breakdown Free
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Dimitra Skondra; Kousuke Noda; Lama Almulki; Faryan Tayyari; Sonja Frimmel; Toru Nakazawa; Ivana K. Kim; Souska Zandi; Kennard L. Thomas; Joan W. Miller; Evangelos S. Gragoudas; Ali Hafezi-Moghadam
Tags: aprotinin, blood-retinal barrier, diabetes mellitus, retina, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 726-731. doi:https://doi.org/10.1167/iovs.07-0405
Intravitreal Injection of Erythropoietin Protects both Retinal Vascular and Neuronal Cells in Early Diabetes Free
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Jingfa Zhang; Yalan Wu; Ying Jin; Fei Ji; Stephen H. Sinclair; Yan Luo; Guoxu Xu; Luo Lu; Wei Dai; Myron Yanoff; Weiye Li; Guo-Tong Xu
Tags: diabetes mellitus, diabetes mellitus, type 2, intravitreal injections, erythropoietin receptors, erythropoietin
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 732-742. doi:https://doi.org/10.1167/iovs.07-0721
Complement-Associated Deposits in the Human Retina Free
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Aditya Seth; Jing Cui; Eleanor To; Melissa Kwee; Joanne Matsubara
Tags: body tissue, cd36 antigens, complement membrane attack complex, complement system proteins, donors
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 743-750. doi:https://doi.org/10.1167/iovs.07-1072
Cone Dystrophy with Supernormal Rod Response Is Strictly Associated with Mutations in KCNV2 Free
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Bernd Wissinger; Susann Dangel; Herbert Jägle; Lars Hansen; Britta Baumann; Günther Rudolph; Christiane Wolf; Michael Bonin; Katja Koeppen; Thomas Ladewig; Susanne Kohl; Eberhart Zrenner; Thomas Rosenberg
Tags: cone dystrophy, mutation, rod photoreceptors, genes, screening
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 751-757. doi:https://doi.org/10.1167/iovs.07-0471
Influence of Intraoperative Course on Visual Outcome after an RPE–Choroid Translocation Free
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Kristel Maaijwee; Tom Missotten; Paul Mulder; Jan C. van Meurs
Tags: choroid, intraoperative care, surgical procedures, operative, translocation (genetics), surgery specialty
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 758-761. doi:https://doi.org/10.1167/iovs.07-0510

Retinal Cell Biology

Expression of Osteopontin in the Rat Retina: Effects of Excitotoxic and Ischemic Injuries Free
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Glyn Chidlow; John P. M. Wood; Jim Manavis; Neville N. Osborne; Robert J. Casson
Tags: ischemia, osteopontin, retina, wounds and injuries, rna, messenger
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 762-771. doi:https://doi.org/10.1167/iovs.07-0726
Restoration of Lysosomal pH in RPE Cells from Cultured Human and ABCA4−/− Mice: Pharmacologic Approaches and Functional Recovery Free
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Ji Liu; Wennan Lu; David Reigada; Jonathan Nguyen; Alan M. Laties; Claire H. Mitchell
Tags: mice, pharmacology, retinal pigment cell, recovery of function, tamoxifen
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 772-780. doi:https://doi.org/10.1167/iovs.07-0675
Retardation of Photoreceptor Degeneration in the Detached Retina of rd1 Mouse Free
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Hiroki Kaneko; Koji M. Nishiguchi; Makoto Nakamura; Shu Kachi; Hiroko Terasaki
Tags: eye, mice, photoreceptors, retinal detachment, tissue degeneration
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 781-787. doi:https://doi.org/10.1167/iovs.07-0715
A Novel Serum-Free Method for Culturing Human Prenatal Retinal Pigment Epithelial Cells Free
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David M. Gamm; J. Nicholas Melvan; Rebecca L. Shearer; Isabel Pinilla; Grzegorz Sabat; Clive N. Svendsen; Lynda S. Wright
Tags: prenatal care, proteins, retinal pigment cell, fibroblast growth factor 2
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 788-799. doi:https://doi.org/10.1167/iovs.07-0777
The Protective Effect of Functional Connexin43 Channels on a Human Epithelial Cell Line Exposed to Oxidative Stress Free
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Cindy M. L. Hutnik; Cady E. Pocrnich; Hong Liu; Dale W. Laird; Qing Shao
Tags: connexin 43, oxidative stress, cell death
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 800-806. doi:https://doi.org/10.1167/iovs.07-0717

Visual Neuroscience

Local Neuroretinal Function during Acute Hypoxia in Healthy Older People Free
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Beatrix Feigl; Ian B. Stewart; Brian Brown; Andrew J. Zele
Tags: hypoxia, older adult
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 807-813. doi:https://doi.org/10.1167/iovs.07-0994
The Cone Electroretinogram in Retinopathy of Prematurity Free
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Anne B. Fulton; Ronald M. Hansen; Anne Moskowitz
Tags: electroretinography, retinal cone, retinopathy of prematurity, rod photoreceptors
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 814-819. doi:https://doi.org/10.1167/iovs.07-1226

Visual Psychophysics and Physiological Optics

Mild Hypoxia Impairs Chromatic Sensitivity in the Mesopic Range Free
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Desmond M. Connolly; John L. Barbur; Sarah L. Hosking; Ian R. Moorhead
Tags: hypoxia, color, luminance, inspiration, respiration
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 820-827. doi:https://doi.org/10.1167/iovs.07-1004
Nonlinear Mixed-Effects Modeling of MNREAD Data Free
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Sing-Hang Cheung; Christopher S. Kallie; Gordon E. Legge; Allen M. Y. Cheong
Tags: limb, reading speed, seizures, emmetropia, fitting curve to data
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 828-835. doi:https://doi.org/10.1167/iovs.07-0555
Additivity of Near Work–Induced Transient Myopia and Its Decay Characteristics in Different Refractive Groups Free
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Balamurali Vasudevan; Kenneth J. Ciuffreda
Tags: myopia, myopia transient, premenstrual syndrome, reading (activity), eye
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 836-841. doi:https://doi.org/10.1167/iovs.07-0197

Research Opportunities

Report from the NEI/FDA Ophthalmic Clinical Trial Design and Endpoints Symposium* Free
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Karl G. Csaky; Elaine A. Richman; Frederick L. Ferris, III
Tags: eye, surrogate endpoints, united states food and drug administration, visual acuity
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 479-489. doi:https://doi.org/10.1167/iovs.07-1132

Erratum

Erratum in: Sideslip of the Medial Rectus Muscle during Vertical Eye Rotation Free
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Kyoung-Min Lee; Annie P. Lai; James Brodale; Arthur Jampolsky
Investigative Ophthalmology & Visual Science February 2008, Vol.49, 527. doi:
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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