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Anatomy and Pathology/Oncology

Peripheral Refraction in Normal Infant Rhesus Monkeys Free
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Li-Fang Hung; Ramkumar Ramamirtham; Juan Huang; Ying Qiao-Grider; Earl L. Smith, III
Tags: cercopithecidae, eye, hyperopia, infant, macaca mulatta
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3747-3757. doi:https://doi.org/10.1167/iovs.07-1493

Biochemistry and Molecular Biology

Transcriptional Regulation of the Human α6 Integrin Gene by the Transcription Factor NFI during Corneal Wound Healing Free
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Manon Gaudreault; François Vigneault; Marie-Eve Gingras; Steeve Leclerc; Patrick Carrier; Lucie Germain; Sylvain L. Guérin
Tags: cornea, dna, genes, integrins, transcription factor
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3758-3767. doi:https://doi.org/10.1167/iovs.08-1913
A Genome-wide Scan Maps a Novel High Myopia Locus to 5p15 Free
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Ching Yan Lam; Pancy O. S. Tam; Dorothy S. P. Fan; Bao Jian Fan; Dan Yi Wang; Coral W. S. Lee; Chi Pui Pang; Dennis S. C. Lam
Tags: genome, myopia, maps
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3768-3778. doi:https://doi.org/10.1167/iovs.07-1126
On the Lipid Composition of Human Meibum and Tears: Comparative Analysis of Nonpolar Lipids Free
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Igor A. Butovich
Tags: lipids, high pressure liquid chromatography procedure
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3779-3789. doi:https://doi.org/10.1167/iovs.08-1889
Trefoil Factor TFF1-Induced Protection of Conjunctival Cells from Apoptosis at Premitochondrial and Postmitochondrial Levels Free
PDF
Nelly Buron; Leslie Guery; Catherine Creuzot-Garcher; Pierre-Olivier Lafontaine; Alain Bron; Marie-Christine Rio; Eric Solary
Tags: apoptosis, burkina faso, conjunctiva, immunoblotting, peptides
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3790-3798. doi:https://doi.org/10.1167/iovs.07-1270
Allelic Copy Number Variation in FSCN2 Detected Using Allele-Specific Genotyping and Multiplex Real-Time PCRs Free
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Zi-Bing Jin; Michiko Mandai; Kohei Homma; Chie Ishigami; Yasuhiko Hirami; Nobuhisa Nao-i; Masayo Takahashi
Tags: alleles, copy number polymorphism, genes, genotype determination, mutation
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3799-3805. doi:https://doi.org/10.1167/iovs.07-1656
ATM Gene Variants in Patients with Idiopathic Perifoveal Telangiectasia Free
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Irene A. Barbazetto; Miia Room; Nicholas A. Yannuzzi; Gaetano R. Barile; Joanna E. Merriam; Anne M. C. Bardal; K. Bailey Freund; Lawrence A. Yannuzzi; Rando Allikmets
Tags: atm gene, telangiectasis
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3806-3811. doi:https://doi.org/10.1167/iovs.07-1357
Duplication and Divergence of Zebrafish CRALBP Genes Uncovers Novel Role for RPE- and Müller-CRALBP in Cone Vision Free
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Ross Collery; Sarah McLoughlin; Victor Vendrell; Jennifer Finnegan; John W. Crabb; John C. Saari; Breandán N. Kennedy
Tags: genes, retinal cone, vision, zebrafish
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3812-3820. doi:https://doi.org/10.1167/iovs.08-1957
Accelerated Accumulation of Lipofuscin Pigments in the RPE of a Mouse Model for ABCA4-Mediated Retinal Dystrophies following Vitamin A Supplementation Free
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Roxana A. Radu; Quan Yuan; Jane Hu; Jennifer H. Peng; Marcia Lloyd; Steven Nusinowitz; Dean Bok; Gabriel H. Travis
Tags: lipofuscin, mice, pigment, vitamin a, retinal dystrophies
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3821-3829. doi:https://doi.org/10.1167/iovs.07-1470
Decreased Levels of the RNA Splicing Factor Prpf3 in Mice and Zebrafish Do Not Cause Photoreceptor Degeneration Free
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John J. Graziotto; Chris F. Inglehearn; Michael A. Pack; Eric A. Pierce
Tags: mice, photoreceptors, rna splicing, tissue degeneration, zebrafish
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3830-3838. doi:https://doi.org/10.1167/iovs.07-1483

Clinical and Epidemiologic Research

Heritability of the Severity of Diabetic Retinopathy: The FIND-Eye Study Free
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Nedal H. Arar; Barry I. Freedman; Sharon G. Adler; Sudha K. Iyengar; Emily Y. Chew; Mathew D. Davis; Scott G. Satko; Donald W. Bowden; Ravi Duggirala; Robert C. Elston; Xiuxing Guo; Robert L. Hanson; Robert P. Igo, Jr; Eli Ipp; Paul L. Kimmel; William C. Knowler; Julio Molineros; Robert G. Nelson; Madeleine V. Pahl; Shannon R. E. Quade; Rebekah S. Rasooly; Jerome I. Rotter; Mohammed F. Saad; Marina Scavini; Jeffrey R. Schelling; John R. Sedor; Vallabh O. Shah; Philip G. Zager; Hanna E. Abboud
Tags: diabetes mellitus, diabetes mellitus, type 2, diabetic retinopathy, eye, kidney diseases
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3839-3845. doi:https://doi.org/10.1167/iovs.07-1633
The Prevalence and Types of Glaucoma in Malay People: The Singapore Malay Eye Study Free
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Sunny Y. Shen; Tien Y. Wong; Paul J. Foster; Jing-Liang Loo; Mohamad Rosman; Seng-Chee Loon; Wan Ling Wong; Seang-Mei Saw; Tin Aung
Tags: eye, glaucoma, prevalence, singapore, open-angle glaucoma
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3846-3851. doi:https://doi.org/10.1167/iovs.08-1759
Cornea Biomechanical Characteristics and Their Correlates with Refractive Error in Singaporean Children Free
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Laurence Lim; Gus Gazzard; Yiong-Huak Chan; Allan Fong; Aachal Kotecha; Ee-Ling Sim; Donald Tan; Louis Tong; Seang-Mei Saw
Tags: child, cornea, refractive errors
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3852-3857. doi:https://doi.org/10.1167/iovs.07-1670
Myopia and the Urban Environment: Findings in a Sample of 12-Year-Old Australian School Children Free
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Jenny M. Ip; Kathryn A. Rose; Ian G. Morgan; George Burlutsky; Paul Mitchell
Tags: child, myopia, school-age child
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3858-3863. doi:https://doi.org/10.1167/iovs.07-1451
Oral Supplementation of Lutein/Zeaxanthin and Omega-3 Long Chain Polyunsaturated Fatty Acids in Persons Aged 60 Years or Older, with or without AMD Free
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Lynn L. Huang; Hanna R. Coleman; Jonghyeon Kim; Francisco de Monasterio; Wai T. Wong; Rosemary L. Schleicher; Frederick L. Ferris, III; Emily Y. Chew
Tags: lutein, polyunsaturated fatty acids, omega-3 fatty acids
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3864-3869. doi:https://doi.org/10.1167/iovs.07-1420

Cornea

Vascular Endothelial Growth Factor Mediates Corneal Nerve Repair Free
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Charles Q. Yu; Min Zhang; Krisztina I. Matis; Charles Kim; Mark I. Rosenblatt
Tags: cornea, vascular endothelial growth factor a, neurons, repair of nerve, trigeminal ganglion
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3870-3878. doi:https://doi.org/10.1167/iovs.07-1418
Characterization and Comparison of Intercellular Adherent Junctions Expressed by Human Corneal Endothelial Cells In Vivo and In Vitro Free
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Ying-Ting Zhu; Yasutaka Hayashida; Ahmad Kheirkhah; Hua He; Szu-Yu Chen; Scheffer C. G. Tseng
Tags: adherent junction, cornea, endothelial cells, cadherins, n-cadherins
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3879-3886. doi:https://doi.org/10.1167/iovs.08-1693
Tissue-Engineered Recombinant Human Collagen-Based Corneal Substitutes for Implantation: Performance of Type I versus Type III Collagen Free
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Kimberley Merrett; Per Fagerholm; Christopher R. McLaughlin; Subhadra Dravida; Neil Lagali; Naoshi Shinozaki; Mitchell A. Watsky; Rejean Munger; Yasuhiro Kato; Fengfu Li; Christopher J. Marmo; May Griffith
Tags: body tissue, collagen, collagen type iii, cornea, implantation procedure
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3887-3894. doi:https://doi.org/10.1167/iovs.07-1348
Innervation of Tissue-Engineered Recombinant Human Collagen-Based Corneal Substitutes: A Comparative In Vivo Confocal Microscopy Study Free
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Neil Lagali; May Griffith; Per Fagerholm; Kimberley Merrett; Melissa Huynh; Rejean Munger
Tags: body tissue, collagen, cornea, microscopy, confocal, nerve supply
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3895-3902. doi:https://doi.org/10.1167/iovs.07-1354
A Rapid Separation of Two Distinct Populations of Mouse Corneal Epithelial Cells with Limbal Stem Cell Characteristics by Centrifugation on Percoll Gradient Free
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Magdalena Krulova; Katerina Pokorna; Anna Lencova; Jan Fric; Alena Zajicova; Martin Filipec; John V. Forrester; Vladimir Holan
Tags: centrifugation, corneal epithelial cells, mice, stem cells, phenotype
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3903-3908. doi:https://doi.org/10.1167/iovs.08-1987
Differential Suppression of Vascular Permeability and Corneal Angiogenesis by Nonsteroidal Anti-inflammatory Drugs Free
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Pouya Pakneshan; Amy E. Birsner; Irit Adini; Christian M. Becker; Robert J. D'Amato
Tags: anti-inflammatory agents, non-steroidal, corneal neovascularization, vascular endothelial growth factor a, vascular permeability, fibroblast growth factor 2
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3909-3913. doi:https://doi.org/10.1167/iovs.07-1527
Fine Structure of the Interface between the Anterior Limiting Lamina and the Anterior Stromal Fibrils of the Human Cornea Free
PDF
Jessica H. Mathew; Jan P. G. Bergmanson; Michael J. Doughty
Tags: cornea, fibril
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3914-3918. doi:https://doi.org/10.1167/iovs.07-0707
A Viscoelastic Biomechanical Model of the Cornea Describing the Effect of Viscosity and Elasticity on Hysteresis Free
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Dianne H. Glass; Cynthia J. Roberts; Alan S. Litsky; Paul A. Weber
Tags: cornea, elasticity, hysteresis, viscosity, stress
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3919-3926. doi:https://doi.org/10.1167/iovs.07-1321

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

The Effect of Acute Superior Oblique Palsy on Vertical Pursuit in Monkeys Free
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Jing Tian; Xiaoyan Shan; Howard S. Ying; Mark F. Walker; Rafael J. Tamargo; David S. Zee
Tags: cercopithecidae, eye, fourth cranial nerve palsy, standard operating procedure, velocity
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3927-3932. doi:https://doi.org/10.1167/iovs.08-1699
Initiation and Stability of Pursuit Eye Movements in Simulated Retinal Prosthesis at Different Implant Locations Free
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Lin Wang; Liancheng Yang; Gislin Dagnelie
Tags: eye movement, implants, prostheses, pursuit eye movement, vision
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3933-3939. doi:https://doi.org/10.1167/iovs.07-1346
Temporal Instability in Amblyopic Vision: Relationship to a Displacement Map of Visual Space Free
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Ruxandra Sireteanu; Claudia C. Bäumer; Adrian Iftime
Tags: amblyopia, vision, perception, eye
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3940-3954. doi:https://doi.org/10.1167/iovs.07-0351

Glaucoma

Lovastatin Inhibits TGF-β–Induced Myofibroblast Transdifferentiation in Human Tenon Fibroblasts Free
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Tobias Meyer-ter-Vehn; Barbara Katzenberger; Hong Han; Franz Grehn; Günther Schlunck
Tags: lovastatin, fibroblasts, myofibroblasts, cell transdifferentiation
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3955-3960. doi:https://doi.org/10.1167/iovs.07-1610
Cultured Porcine Trabecular Meshwork Cells Display Altered Lysosomal Function When Subjected to Chronic Oxidative Stress Free
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Paloma B. Liton; Yizhi Lin; Coralia Luna; Guorong Li; Pedro Gonzalez; David L. Epstein
Tags: oxidative stress, suidae, trabecular meshwork, proteins
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3961-3969. doi:https://doi.org/10.1167/iovs.08-1915
Analysis of HRT Images: Comparison of Reference Planes Free
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Alessandro Poli; Nicholas G. Strouthidis; Tuan A. Ho; David F. Garway-Heath
Tags: eye, follow-up, glaucoma, heidelberg retina tomograph, ocular hypertension
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3970-3975. doi:https://doi.org/10.1167/iovs.08-1764
Association of LOXL1 Gene Polymorphisms with Pseudoexfoliation in the Japanese Free
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Mineo Ozaki; Kelvin Y. C. Lee; Eranga N. Vithana; Victor H. Yong; Anbupalam Thalamuthu; Takanori Mizoguchi; Anandalakshmi Venkatraman; Tin Aung
Tags: genes, japanese, polymorphism, single nucleotide polymorphism, alleles
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3976-3980. doi:https://doi.org/10.1167/iovs.08-1805
Interactions between Trabecular Meshwork Cells and Lens Epithelial Cells: A Possible Mechanism in Infantile Aphakic Glaucoma Free
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Inbal Michael; Michael Shmoish; David S. Walton; Shulamit Levenberg
Tags: coculture techniques, gene expression, glaucoma, lens epithelial cell, proteins
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3981-3987. doi:https://doi.org/10.1167/iovs.08-1674

Immunology and Microbiology

Soluble gp130, an Antagonist of IL-6 Transsignaling, Is Elevated in Uveitis Aqueous Humor Free
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Diana Simon; Alastair K. O. Denniston; Paul J. Tomlins; Graham R. Wallace; Saaeha Rauz; Mike Salmon; Philip I. Murray; S. John Curnow
Tags: antagonists, aqueous humor, interleukin-6, uveitis, cytokine
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3988-3991. doi:https://doi.org/10.1167/iovs.08-1953
Regulation of the Receptor for TNFα, TNFR1, in Human Conjunctival Epithelial Cells Free
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Ellen B. Cook; James L. Stahl; Frank M. Graziano; Neal P. Barney
Tags: chemoembolization, therapeutic, conjunctiva, conjunctival epithelial cells, epithelial cells, intercellular adhesion molecule 1
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3992-3998. doi:https://doi.org/10.1167/iovs.08-1873
Ocular Regulatory T Cells Distinguish Monophasic from Recurrent Autoimmune Uveitis Free
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Yan Ke; Guomin Jiang; Deming Sun; Henry J. Kaplan; Hui Shao
Tags: antigens, cd25, autoimmune diseases, autoimmunity, eye, recurrence
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3999-4007. doi:https://doi.org/10.1167/iovs.07-1468
The B Subunit of Escherichia coli Heat-Labile Enterotoxin Inhibits Th1 but Not Th17 Cell Responses in Established Experimental Autoimmune Uveoretinitis Free
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Ben J. E. Raveney; Claire Richards; Marie-Laure Aknin; David A. Copland; Bronwen R. Burton; Emma Kerr; Lindsay B. Nicholson; Neil A. Williams; Andrew D. Dick
Tags: autoimmune diseases, autoimmunity, enterotoxins, escherichia coli, eye
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 4008-4017. doi:https://doi.org/10.1167/iovs.08-1848
Neutrophils Protect the Retina of the Injected Eye from Infection after Anterior Chamber Inoculation of HSV-1 in BALB/c Mice Free
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Mei Zheng; Mark A. Fields; Yi Liu; Heather Cathcart; Elizabeth Richter; Sally S. Atherton
Tags: eye, human herpesvirus 1, infections, mice, neutrophils
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 4018-4025. doi:https://doi.org/10.1167/iovs.08-1914
HVEM and Nectin-1 Are the Major Mediators of Herpes Simplex Virus 1 (HSV-1) Entry into Human Conjunctival Epithelium Free
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Jihan Akhtar; Vaibhav Tiwari; Myung-Jin Oh; Maria Kovacs; Aarti Jani; S. Krisztian Kovacs; Tibor Valyi-Nagy; Deepak Shukla
Tags: antibodies, human herpesvirus 1, conjunctival epithelium, viruses, entry of virus into host cell
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 4026-4035. doi:https://doi.org/10.1167/iovs.08-1807

Physiology and Pharmacology

The Anti-inflammatory Effects of Curcuma longa and Berberis aristata in Endotoxin-Induced Uveitis in Rabbits Free
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Suresh Kumar Gupta; Renu Agarwal; Sushma Srivastava; Puneet Agarwal; Shyam Sunder Agrawal; Rohit Saxena; Niranjan Galpalli
Tags: anti-inflammatory agents, berberis (plant), curcuma, endotoxins, oryctolagus cuniculus
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 4036-4040. doi:https://doi.org/10.1167/iovs.07-1186
Human Transscleral Albumin Permeability and the Effect of Topographical Location and Donor Age Free
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Owen A. Anderson; Timothy L. Jackson; Jasmin K. Singh; Ali A. Hussain; John Marshall
Tags: albumins, donors, permeability, sclera
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 4041-4045. doi:https://doi.org/10.1167/iovs.07-1660
Estimation of Ocular Rigidity Based on Measurement of Pulse Amplitude Using Pneumotonometry and Fundus Pulse Using Laser Interferometry in Glaucoma Free
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Anton Hommer; Gabriele Fuchsjäger-Mayrl; Hemma Resch; Clemens Vass; Gerhard Garhofer; Leopold Schmetterer
Tags: glaucoma, interferometry, muscle rigidity, open-angle glaucoma, intraocular pressure
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 4046-4050. doi:https://doi.org/10.1167/iovs.07-1342

Retina

Does Functional Vision Behave Differently in Low-Vision Patients with Diabetic Retinopathy?—A Case-Matched Study Free
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Lohrasb Ahmadian; Robert Massof
Tags: diabetic retinopathy, vision, visual impairment
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 4051-4057. doi:https://doi.org/10.1167/iovs.07-1507
Influence of a Quantitative Trait Locus on Mouse Chromosome 19 to the Light-Adapted Electroretinogram Free
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Alison L. Reynolds; Michael Danciger; G. Jane Farrar; Peter Humphries; Paul F. Kenna
Tags: electroretinography, mice, quantitative trait loci, chromosomes, human, pair 19
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 4058-4063. doi:https://doi.org/10.1167/iovs.07-1620
Plus Disease in Retinopathy of Prematurity: Development of Composite Images by Quantification of Expert Opinion Free
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Michael F. Chiang; Rony Gelman; Steven L. Williams; Joo-Yeon Lee; Daniel S. Casper; M. Elena Martinez-Perez; John T. Flynn
Tags: computers, expert opinion, retinopathy of prematurity, diameter
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 4064-4070. doi:https://doi.org/10.1167/iovs.07-1524
Neuroprotective Effect of Intravitreal Triamcinolone Acetonide against Photoreceptor Apoptosis in a Rabbit Model of Subretinal Hemorrhage Free
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Robert B. Bhisitkul; Bryan J. Winn; On-Tat Lee; Joshua Wong; Daniel de Souza Pereira; Travis C. Porco; Xining He; Paul Hahn; Joshua L. Dunaief
Tags: apoptosis, hemorrhage, oryctolagus cuniculus, photoreceptors, triamcinolone acetonide
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 4071-4077. doi:https://doi.org/10.1167/iovs.08-1892
Connective Tissue Growth Factor as a Mediator of Intraocular Fibrosis Free
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Shikun He; Youxin Chen; Rima Khankan; Ernesto Barron; Richard Burton; DanHong Zhu; Stephen J. Ryan; Noelynn Oliver; David R. Hinton
Tags: connective tissue growth factor, fibrosis, oryctolagus cuniculus
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 4078-4088. doi:https://doi.org/10.1167/iovs.07-1302
Collagen Distribution in the Human Vitreoretinal Interface Free
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Theodorus L. Ponsioen; Marja J. A. van Luyn; Roelofje J. van der Worp; Jan C. van Meurs; Johanna M. M. Hooymans; Leonoor I. Los
Tags: collagen, retina, vitreous body
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 4089-4095. doi:https://doi.org/10.1167/iovs.07-1456
Syndromic Choroideremia: Sublocalization of Phenotypes Associated with Martin-Probst Deafness Mental Retardation Syndrome Free
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Charlotte M. Poloschek; Barbara Kloeckener-Gruissem; Lutz L. Hansen; Michael Bach; Wolfgang Berger
Tags: choroideremia, family, hearing loss, intellectual disability, phenotype
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 4096-4104. doi:https://doi.org/10.1167/iovs.08-2044
Identification and Functional Characterization of a Novel Rhodopsin Mutation Associated with Autosomal Dominant CSNB Free
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Christina Zeitz; Alecia K. Gross; Dorothee Leifert; Barbara Kloeckener-Gruissem; Suzanne D. McAlear; Johannes Lemke; John Neidhardt; Wolfgang Berger
Tags: mutation, night blindness, congenital stationary, rhodopsin, transducin, opsin
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 4105-4114. doi:https://doi.org/10.1167/iovs.08-1717
A Novel Rabbit Model for Studying RPE Transplantation Free
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Lidan Cong; Dawei Sun; Zhongyu Zhang; Wanqiu Jiao; Lawrence J. Rizzolo; Shaomin Peng
Tags: newborn, oryctolagus cuniculus, retinal pigment cell, transplantation
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 4115-4125. doi:https://doi.org/10.1167/iovs.08-1976
Evaluation of Adenovirus-Delivered Human CD59 as a Potential Therapy for AMD in a Model of Human Membrane Attack Complex Formation on Murine RPE Free
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Kasmir Ramo; Siobhan M. Cashman; Rajendra Kumar-Singh
Tags: adenovirus infections, adenoviruses, antigens, cd59, complement membrane attack complex, mice
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 4126-4136. doi:https://doi.org/10.1167/iovs.08-2025
High-Resolution Spectral Domain-OCT Imaging in Geographic Atrophy Associated with Age-Related Macular Degeneration Free
PDF
Monika Fleckenstein; Peter Charbel Issa; Hans-Martin Helb; Steffen Schmitz-Valckenberg; Robert P. Finger; Hendrik P. N. Scholl; Karin U. Loeffler; Frank G. Holz
Tags: age-related macular degeneration, atrophic condition of skin, atrophy, diagnostic imaging, eye
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 4137-4144. doi:https://doi.org/10.1167/iovs.08-1967

Retinal Cell Biology

Reprogramming Progeny Cells of Embryonic RPE to Produce Photoreceptors: Development of Advanced Photoreceptor Traits under the Induction of neuroD Free
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Lina Liang; Run-Tao Yan; Xiumei Li; Melissa Chimento; Shu-Zhen Wang
Tags: child, embryo, offspring, photoreceptors, diagnostic imaging
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 4145-4153. doi:https://doi.org/10.1167/iovs.07-1380
In Vivo Protection against Retinal Neurodegeneration by Sigma Receptor 1 Ligand (+)-Pentazocine Free
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Sylvia B. Smith; Jennifer Duplantier; Ying Dun; Barbara Mysona; Penny Roon; Pamela M. Martin; Vadivel Ganapathy
Tags: ligands, mice, pentazocine, receptors, sigma, nerve degeneration
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 4154-4161. doi:https://doi.org/10.1167/iovs.08-1824
Characteristics of Bone Marrow–Derived Microglia in the Normal and Injured Retina Free
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Hiroki Kaneko; Koji M. Nishiguchi; Makoto Nakamura; Shu Kachi; Hiroko Terasaki
Tags: microglia, retina, bone marrow, retinal detachment
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 4162-4168. doi:https://doi.org/10.1167/iovs.08-1738
Ex Vivo Dynamic Imaging of Retinal Microglia Using Time-Lapse Confocal Microscopy Free
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Jung Eun Lee; Katharine J. Liang; Robert N. Fariss; Wai T. Wong
Tags: diagnostic imaging, microglia, microscopy, confocal, laser injuries, wounds and injuries
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 4169-4176. doi:https://doi.org/10.1167/iovs.08-2076
RhoA and Its Role in Synaptic Structural Plasticity of Isolated Salamander Photoreceptors Free
PDF
Aurora M. Fontainhas; Ellen Townes-Anderson
Tags: photoreceptors, rhoa gtp-binding protein, rod photoreceptors, retinal cone
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 4177-4187. doi:https://doi.org/10.1167/iovs.07-1580
Attenuation of Vision Loss and Delay in Apoptosis of Photoreceptors Induced by Proinsulin in a Mouse Model of Retinitis Pigmentosa Free
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Silvia Corrochano; Rima Barhoum; Patricia Boya; Ana I. Arroba; Natalia Rodríguez-Muela; Violeta Gómez-Vicente; Fátima Bosch; Flora de Pablo; Pedro de la Villa; Enrique J. de la Rosa
Tags: blindness, history of present illness, mice, photoreceptors, proinsulin
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 4188-4194. doi:https://doi.org/10.1167/iovs.08-2182
MCP-1 Deficiency Delays Regression of Pathologic Retinal Neovascularization in a Model of Ischemic Retinopathy Free
PDF
Michael H. Davies; Andrew J. Stempel; Michael R. Powers
Tags: mice, monocyte chemoattractant protein-1, retinal diseases, retinal neovascularization, ischemia
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 4195-4202. doi:https://doi.org/10.1167/iovs.07-1491
Mitochondrial DNA Oxidative Damage Triggering Mitochondrial Dysfunction and Apoptosis in High Glucose-Induced HRECs Free
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Lin Xie; Xiaobo Zhu; Yiqun Hu; Tao Li; Yi Gao; Yu Shi; Shibo Tang
Tags: apoptosis, dna, mitochondrial, glucose, mitochondria, pathophysiology
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 4203-4209. doi:https://doi.org/10.1167/iovs.07-1364

Visual Psychophysics and Physiological Optics

Use of Visual Search in the Assessment of Pattern-Related Visual Stress (PRVS) and Its Alleviation by Colored Filters Free
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Peter M. Allen; James M. Gilchrist; Jarrod Hollis
Tags: reading (activity), stress, visual search, filters, reaction time
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 4210-4218. doi:https://doi.org/10.1167/iovs.07-1587

Clinical Trials

Quantification of Metamorphopsia in Patients with Macular Hole Free
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Kristian Krøyer; Ulrik Christensen; Michael Larsen; Morten la Cour
Tags: macular holes, metamorphopsias, health disparity
Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3741-3746. doi:https://doi.org/10.1167/iovs.07-1452

Erratum

ERRATUM Free
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Investigative Ophthalmology & Visual Science September 2008, Vol.49, 3811. doi:
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