Volume 51 Issue 3 | IOVS

Mouse Experimental Myopia Has Features of Primate Myopia Free

Tatiana V. Tkatchenko; Yimin Shen; Andrei V. Tkatchenko

Tags: mice, myopia, primates, lens (device), lens, crystalline

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1297-1303. doi:https://doi.org/10.1167/iovs.09-4153

Soluble and Mature Amyloid Fibrils in Drusen Deposits Free

J. Mario Isas; Volker Luibl; Lincoln V. Johnson; Rakez Kayed; Ronald Wetzel; Charles G. Glabe; Ralf Langen; Jeannie Chen

Tags: amyloid fibrils, drusen, amyloid, antibodies, oligomers

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1304-1310. doi:https://doi.org/10.1167/iovs.09-4207

Biochemistry and Molecular Biology

Microarray-Based Mutation Analysis of 183 Spanish Families with Usher Syndrome Free

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Teresa Jaijo; Elena Aller; Gema García-García; María J. Aparisi; Sara Bernal; Almudena Ávila-Fernández; Isabel Barragán; Montserrat Baiget; Carmen Ayuso; Guillermo Antiñolo; Manuel Díaz-LLopis; Maigi Külm; Magdalena Beneyto; Carmen Nájera; Jose M. Millán

Tags: family, genes, genotype determination, mutation, spanish

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1311-1317. doi:https://doi.org/10.1167/iovs.09-4085

Effects of Human Recombinant PEDF Protein and PEDF-Derived Peptide 34-mer on Choroidal Neovascularization Free

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Juan Amaral; S. Patricia Becerra

Tags: choroidal neovascularization, peptides, proteins, lasers

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1318-1326. doi:https://doi.org/10.1167/iovs.09-4455

The Dependence of Retinal Degeneration Caused by the Rhodopsin P23H Mutation on Light Exposure and Vitamin A Deprivation Free

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Beatrice M. Tam; Ali Qazalbash; Hak-Choel Lee; Orson L. Moritz

Tags: light exposure, retinal degeneration, rhodopsin, vitamin a, mutation

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1327-1334. doi:https://doi.org/10.1167/iovs.09-4123

Clinical and Epidemiologic Research

Replication of a Glaucoma Candidate Gene on 5q22.1 for Intraocular Pressure in Mongolian Populations: The GENDISCAN Project Free

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Mi Kyeong Lee; Se Joon Woo; Jong-il Kim; Sung-il Cho; Ho Kim; Joohon Sung; Jeong-Sun Seo; Dong Myung Kim

Tags: candidate disease gene, glaucoma, intraocular pressure

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1335-1340. doi:https://doi.org/10.1167/iovs.09-3979

Ocular Component Growth Curves among Singaporean Children with Different Refractive Error Status Free

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Hwee-Bee Wong; David Machin; Say-Beng Tan; Tien-Yin Wong; Seang-Mei Saw

Tags: child, emmetropia, hyperopia, myopia, refractive errors

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1341-1347. doi:https://doi.org/10.1167/iovs.09-3431

Prevalence of Refractive Error in Singaporean Chinese Children: The Strabismus, Amblyopia, and Refractive Error in Young Singaporean Children (STARS) Study Free

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Mohamed Dirani; Yiong-Huak Chan; Gus Gazzard; Dana Marie Hornbeak; Seo-Wei Leo; Prabakaran Selvaraj; Brendan Zhou; Terri L. Young; Paul Mitchell; Rohit Varma; Tien Yin Wong; Seang-Mei Saw

Tags: amblyopia, child, chinese (other dialects), myopia, prevalence

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1348-1355. doi:https://doi.org/10.1167/iovs.09-3587

Cornea

Endothelial Morphometry by Image Analysis of Corneas Organ Cultured at 31°C Free

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Sophie Acquart; Philippe Gain; Min Zhao; Yann Gavet; Alexandre Defreyn; Simone Piselli; Olivier Garraud; Gilles Thuret

Tags: cornea, endothelium

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1356-1364. doi:https://doi.org/10.1167/iovs.08-3103

Differential Relative Sulfation of Keratan Sulfate Glycosaminoglycan in the Chick Cornea during Embryonic Development Free

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Melody Liles; Barbara P. Palka; Anthony Harris; Briedgeen Kerr; Clare Hughes; Robert D. Young; Keith M. Meek; Bruce Caterson; Andrew J. Quantock

Tags: collagen, cornea, embryologic development, glycosaminoglycans, keratan sulfate

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1365-1372. doi:https://doi.org/10.1167/iovs.09-4004

Nanoscale Topography–Induced Modulation of Fundamental Cell Behaviors of Rabbit Corneal Keratocytes, Fibroblasts, and Myofibroblasts Free

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Simon A. Pot; Sara J. Liliensiek; Kathern E. Myrna; Ellison Bentley; James V. Jester; Paul F. Nealey; Christopher J. Murphy

Tags: cornea, fibroblasts, keratocytes, myofibroblasts, oryctolagus cuniculus

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1373-1381. doi:https://doi.org/10.1167/iovs.09-4074

Human Corneal Fibrosis: An In Vitro Model Free

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Dimitris Karamichos; Xiaoqing Q. Guo; Audrey E. K. Hutcheon; James D. Zieske

Tags: cornea, fibrosis, fibril, fibroblasts, collagen

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1382-1388. doi:https://doi.org/10.1167/iovs.09-3860

Effect of Mitomycin C on IL-1R Expression, IL-1–Related Hepatocyte Growth Factor Secretion and Corneal Epithelial Cell Migration Free

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Tsan-Chi Chen; Shu-Wen Chang

Tags: bodily secretions, cornea, corneal epithelial cells, fibroblasts, hepatocyte growth factor

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1389-1396. doi:https://doi.org/10.1167/iovs.09-3494

An In Vivo Confocal Microscopy and Impression Cytology Analysis of Goblet Cells in Patients with Chemical Burns Free

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Qi-hua Le; Wen-tao Wang; Jia-xu Hong; Xing-huai Sun; Tian-yu Zheng; Wen-qing Zhu; Jian-jiang Xu

Tags: chemical burns, cytology, goblet cells, microscopy, confocal, conjunctiva

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1397-1400. doi:https://doi.org/10.1167/iovs.09-3886

McMonnies Questionnaire: Enhancing Screening for Dry Eye Syndromes with Rasch Analysis Free

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Vijaya K. Gothwal; Konrad Pesudovs; Thomas A. Wright; Charles W. McMonnies

Tags: dry eye syndromes, questionnaires, rasch model, screening

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1401-1407. doi:https://doi.org/10.1167/iovs.09-4180

Corneal Reconstruction with Tissue-Engineered Cell Sheets Composed of Human Immature Dental Pulp Stem Cells Free

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José Álvaro Pereira Gomes; Bábyla Geraldes Monteiro; Gustavo Barreto Melo; Ricardo Luiz Smith; Marcelo Cavenaghi Pereira da Silva; Nelson Foresto Lizier; Alexandre Kerkis; Humberto Cerruti; Irina Kerkis

Tags: body tissue, cornea, dental pulp, reconstructive surgical procedures, stem cells

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1408-1414. doi:https://doi.org/10.1167/iovs.09-4029

Cytoskeletal and Cell Adhesion Defects in Wounded and Pax6 ^+/− Corneal Epithelia Free

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Jingxing Ou; Christina Lowes; J. Martin Collinson

Tags: cornea, corneal epithelium, cytoskeleton, mice, cell adhesion

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1415-1423. doi:https://doi.org/10.1167/iovs.09-4023

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Electrophysiological and Histologic Assessment of Retinal Ganglion Cell Fate in a Mouse Model for OPA1-Associated Autosomal Dominant Optic Atrophy Free

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Peter Heiduschka; Sven Schnichels; Nico Fuhrmann; Sabine Hofmeister; Ulrich Schraermeyer; Bernd Wissinger; Marcel V. Alavi

Tags: mice, optic atrophy, autosomal dominant, retinal ganglion cells

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1424-1431. doi:https://doi.org/10.1167/iovs.09-3606

Decreased Gray Matter Concentration in the Lateral Geniculate Nuclei in Human Amblyopes Free

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Gareth R. Barnes; Xingfeng Li; Benjamin Thompson; Krishna D. Singh; Serge O. Dumoulin; Robert F. Hess

Tags: amblyopia, cell nucleus, gray matter, mass or substance concentration per volume, visual cortex

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1432-1438. doi:https://doi.org/10.1167/iovs.09-3931

Timing of Corticosteroid Therapy Is Critical to Prevent Retinal Ganglion Cell Loss in Experimental Optic Neuritis Free

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Mahasweta Dutt; Philomela Tabuena; Elvira Ventura; Abdolmohamad Rostami; Kenneth S. Shindler

Tags: dexamethasone, glucocorticoids, optic neuritis, retinal ganglion cells, mice

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1439-1445. doi:https://doi.org/10.1167/iovs.09-4009

Glaucoma

Macular and Peripapillary Retinal Nerve Fiber Layer Measurements by Spectral Domain Optical Coherence Tomography in Normal-Tension Glaucoma Free

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Mincheol Seong; Kyung Rim Sung; Eun Hee Choi; Sung Yong Kang; Jung Woo Cho; Tae Woong Um; Yoon Jeon Kim; Seong Bae Park; Hun Eui Hong; Michael S. Kook

Tags: antigens, cd59, eye, glaucoma, low tension glaucoma, optical coherence tomography

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1446-1452. doi:https://doi.org/10.1167/iovs.09-4258

Aqueous Humor Outflow Facility by Tonography Does Not Change with Body Position Free

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Deepan Selvadurai; David Hodge; Arthur J. Sit

Tags: aqueous humor, intraocular pressure, sitting position, eye, supine position

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1453-1457. doi:https://doi.org/10.1167/iovs.09-4058

Visual Field Progression Differences between Normal-Tension and Exfoliative High-Tension Glaucoma Free

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Kristy G. Ahrlich; Carlos Gustavo V. De Moraes; Christopher C. Teng; Tiago S. Prata; Celso Tello; Robert Ritch; Jeffrey M. Liebmann

Tags: eye, glaucoma, intraocular pressure, visual fields

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1458-1463. doi:https://doi.org/10.1167/iovs.09-3806

A Comparison of Optic Nerve Head Morphology Viewed by Spectral Domain Optical Coherence Tomography and by Serial Histology Free

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Nicholas G. Strouthidis; Jonathan Grimm; Galen A. Williams; Grant A. Cull; David J. Wilson; Claude F. Burgoyne

Tags: histology, optic disk, optical coherence tomography, language morphology, morphology

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1464-1474. doi:https://doi.org/10.1167/iovs.09-3984

Inhibition of Cell Proliferation of Tenon's Capsule Fibroblast by S-Phase Kinase-Interacting Protein 2 Targeting SiRNA through Increasing p27 Protein Level Free

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Feng Wang; Lin Xin Qi; Ying Su; Qing Hui Yan; Yan Teng

Tags: cell proliferation, proteins, rna, small interfering, fibroblasts, tenon's capsule

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1475-1482. doi:https://doi.org/10.1167/iovs.09-4363

Spatiotemporal Characterization of Optic Nerve Degeneration after Chronic Hypoperfusion in the Rat Free

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Glyn Chidlow; Matthew C. Holman; John P. M. Wood; Robert J. Casson

Tags: hypoperfusion, immunohistochemistry, infarction, optic disk, optic nerve

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1483-1497. doi:https://doi.org/10.1167/iovs.09-4603

Clinical Evaluation of the Aqueous Outflow System in Primary Open-Angle Glaucoma for Canaloplasty Free

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Matthias C. Grieshaber; Ané Pienaar; Jan Olivier; Robert Stegmann

Tags: fluorescein, gastroesophageal reflux disease, open-angle glaucoma, intraocular pressure, gonioscopy

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1498-1504. doi:https://doi.org/10.1167/iovs.09-4327

Immunology and Microbiology

Killer Cell Immunoglobulin-like Receptors in HLA-B27–Associated Acute Anterior Uveitis, with and without Axial Spondyloarthropathy Free

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Ralph D. Levinson; Tammy M. Martin; Lihui Luo; Elham Ashouri; James T. Rosenbaum; Justine R. Smith; Carrie R. Austin; Joseph R. Lutt; Raja Rajalingam

Tags: hla-b27 antigen, human leukocyte antigens, receptors, kir, spondylarthropathies, uveitis, anterior

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1505-1510. doi:https://doi.org/10.1167/iovs.09-4232

A Murine Model of Contact Lens–Associated Fusarium Keratitis Free

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Yan Sun; Jyotsna Chandra; Pranab Mukherjee; Loretta Szczotka-Flynn; Mahmoud A. Ghannoum; Eric Pearlman

Tags: biofilms, contact lenses, fusarium, keratitis, mice

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1511-1516. doi:https://doi.org/10.1167/iovs.09-4237

A Fungal pH-Responsive Signaling Pathway Regulating Aspergillus Adaptation and Invasion into the Cornea Free

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Xia Hua; Xiaoyong Yuan; Kirk R. Wilhelmus

Tags: aspergillus, cornea, signal transduction pathways, polyanalgesic consensus panel

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1517-1523. doi:https://doi.org/10.1167/iovs.09-4348

IL-33 Shifts Macrophage Polarization, Promoting Resistance against Pseudomonas aeruginosa Keratitis Free

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Linda D. Hazlett; Sharon A. McClellan; Ronald P. Barrett; Xi Huang; Yunfan Zhang; Minhao Wu; Nico van Rooijen; Elizabeth Szliter

Tags: cornea, cytokine, il1rl1 gene, immunohistochemistry, infections

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1524-1532. doi:https://doi.org/10.1167/iovs.09-3983

M Cell–Targeted Ocular Immunization: Effect on Immunoglobulins in Tears, Feces, and Serum Free

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Thomas E. Phillips; Jeremy Sharp; Kay Rodgers; Hongshan Liu

Tags: antigens, feces, galveston orientation and amnesia test, immunization, immunoglobulin a

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1533-1539. doi:https://doi.org/10.1167/iovs.09-4491

Lens

Cell Fate and Differentiation of the Developing Ocular Lens Free

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Teri M. S. Greiling; Masamoto Aose; John I. Clark

Tags: lens (device), lens, crystalline, zebrafish, embryo, diagnostic imaging

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1540-1546. doi:https://doi.org/10.1167/iovs.09-4388

Natural Course of Elschnig Pearl Formation and Disappearance Free

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Oliver Findl; Thomas Neumayer; Nino Hirnschall; Wolf Buehl

Tags: eye, follow-up, lens (device), after-cataract, lens, crystalline

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1547-1553. doi:https://doi.org/10.1167/iovs.09-3989

Morphology and Accommodative Function of the Vitreous Zonule in Human and Monkey Eyes Free

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Elke Lütjen-Drecoll; Paul L. Kaufman; Rainer Wasielewski; Lin Ting-Li; Mary Ann Croft

Tags: cercopithecidae, eye, language morphology, morphology, ultrasound biomicroscopy

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1554-1564. doi:https://doi.org/10.1167/iovs.09-4008

Posttranslational Modifications of the Bovine Lens Beaded Filament Proteins Filensin and CP49 Free

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Zhen Wang; Joy E. Obidike; Kevin L. Schey

Tags: cattle, lens (device), lens, crystalline, peptides, protein processing, post-translational

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1565-1574. doi:https://doi.org/10.1167/iovs.09-4565

Physiology and Pharmacology

Barrier Dysfunction of the Corneal Endothelium in Response to TNF-α: Role of p38 MAP Kinase Free

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Mahesh Shivanna; Gangaraju Rajashekhar; Sangly P. Srinivas

Tags: mitogen-activated protein kinase p38, tumor necrosis factors, corneal endothelium

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1575-1582. doi:https://doi.org/10.1167/iovs.09-4343

Divergent Roles of Nitric Oxide and Rho Kinase in Vasomotor Regulation of Human Retinal Arterioles Free

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Travis W. Hein; Robert H. Rosa, Jr; Zhaoxu Yuan; Elizabeth Roberts; Lih Kuo

Tags: arteriole, endothelin-1, nitric oxide, phosphotransferases, regulation

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1583-1590. doi:https://doi.org/10.1167/iovs.09-4391

cAMP/PKA-Dependent Increases in Ca Sparks, Oscillations and SR Ca Stores in Retinal Arteriolar Myocytes after Exposure to Vasopressin Free

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Owen Jeffries; Mary K. McGahon; Peter Bankhead; Maria Manfredi Lozano; C. Norman Scholfield; Tim M. Curtis; J. Graham McGeown

Tags: arteriole, caffeine, cyclic amp, forskolin, muscle cells

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1591-1598. doi:https://doi.org/10.1167/iovs.09-4401

Effect of Acute Increase in Blood Pressure on Intraocular Pressure in Pigs and Humans Free

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Hugo Castejon; Christophe Chiquet; Olivier Savy; Jean-Philippe Baguet; Hafid Khayi; Renaud Tamisier; Lionel Bourdon; Jean-Paul Romanet

Tags: blood pressure, intraocular pressure, squatting ability, suidae, hyperventilation

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1599-1605. doi:https://doi.org/10.1167/iovs.09-4215

Pharmacokinetics of Bevacizumab and Its Effect on Vascular Endothelial Growth Factor after Intravitreal Injection of Bevacizumab in Macaque Eyes Free

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Taichiro Miyake; Osamu Sawada; Masashi Kakinoki; Tomoko Sawada; Hajime Kawamura; Kazumasa Ogasawara; Masahito Ohji

Tags: bevacizumab, eye, intravitreal injections, macaca, pharmacokinetics

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1606-1608. doi:https://doi.org/10.1167/iovs.09-4140

Intraocular Pressure during a Very High Altitude Climb Free

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Martina M. Bosch; Daniel Barthelmes; Tobias M. Merz; Frederic Truffer; Pascal B. Knecht; Benno Petrig; Konrad E. Bloch; Urs Hefti; Gregor Schubiger; Klara Landau

Tags: high altitude, intraocular pressure

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1609-1613. doi:https://doi.org/10.1167/iovs.09-4306

Episcleral Venous Pressure Responses to Topical Nitroprusside and N-Nitro-l-arginine Methyl Ester Free

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David O. Zamora; Jeffrey W. Kiel

Tags: arginine, esters, fluid flow, intraocular pressure, nitroprusside sodium

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1614-1620. doi:https://doi.org/10.1167/iovs.09-4530

Retina

Retinal Basement Membrane Abnormalities and the Retinopathy of Alport Syndrome Free

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Judy Savige; John Liu; Delia Cabrera DeBuc; James T. Handa; Gregory S. Hageman; Yan Yan Wang; John D. Parkin; Brendan Vote; Rob Fassett; Shirley Sarks; Deb Colville

Tags: basement membrane, hereditary nephritis, retina, retinal diseases

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1621-1627. doi:https://doi.org/10.1167/iovs.08-3323

Mutation- and Tissue-Specific Alterations of RPGR Transcripts Free

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Fabian Schmid; Esther Glaus; Frans P. M. Cremers; Barbara Kloeckener-Gruissem; Wolfgang Berger; John Neidhardt

Tags: body tissue, exons, mutation, protein isoforms, cell lines

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1628-1635. doi:https://doi.org/10.1167/iovs.09-4031

Sustained Mechanical Release of Dexamethasone Sodium Phosphate from a Foldable Capsular Vitreous Body Free

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Yaqin Liu; Qicheng Ke; Jiajia Chen; Zhichong Wang; Zhiyong Xie; Zhaoxin Jiang; Jian Ge; Qianying Gao

Tags: dexamethasone, vitreous body, high pressure liquid chromatography procedure, vitreous substitute

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1636-1642. doi:https://doi.org/10.1167/iovs.09-4134

A Novel Haplotype with the R345W Mutation in the EFEMP1 Gene Associated with Autosomal Dominant Drusen in a Japanese Family Free

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Tomokazu Takeuchi; Takaaki Hayashi; Matthew Bedell; Kang Zhang; Hisashi Yamada; Hiroshi Tsuneoka

Tags: drusen, family, genes, haplotypes, japanese

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1643-1650. doi:https://doi.org/10.1167/iovs.09-4497

Photoreceptor Inner/Outer Segment Defect Imaging by Spectral Domain OCT and Visual Prognosis after Macular Hole Surgery Free

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Jaeryung Oh; William E. Smiddy; Harry W. Flynn, Jr; Giovanni Gregori; Brandon Lujan

Tags: diagnostic imaging, diameter, eye, macular holes, photoreceptors

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1651-1658. doi:https://doi.org/10.1167/iovs.09-4420

Protective Effect of Clusterin on Blood–Retinal Barrier Breakdown in Diabetic Retinopathy Free

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Jeong-Hun Kim; Jin Hyoung Kim; Young Suk Yu; Bon Hong Min; Kyu-Won Kim

Tags: clusterin, diabetes mellitus, diabetic retinopathy, endothelial cells, proteins

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1659-1665. doi:https://doi.org/10.1167/iovs.09-3615

Role of Multifocal Electroretinography in the Diagnosis of Idiopathic Macular Hole Free

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Rita Tuzson; Balázs Varsanyi; Balázs Vince Nagy; Balázs Lesch; Rita Vámos; János Németh; Ágnes Farkas; Mária Ferencz

Tags: eye, macular holes, electroretinography

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1666-1670. doi:https://doi.org/10.1167/iovs.09-4375

Effects on Choroidal Neovascularization after Anti-VEGF Upload Using Intravitreal Ranibizumab, as Determined by Spectral Domain-Optical Coherence Tomography Free

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Carsten Framme; Georgios Panagakis; Reginald Birngruber

Tags: anti-vascular endothelial growth factor therapy, choroidal neovascularization, ranibizumab, tomography, optics

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1671-1676. doi:https://doi.org/10.1167/iovs.09-4496

A Novel Nonradioactive Method to Evaluate Vascular Barrier Breakdown and Leakage Free

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George Trichonas; Akrivi Manola; Yuki Morizane; Aristomenis Thanos; Xanthi Koufomichali; Thanos D. Papakostas; Sandra Montezuma; Lucy Young; Joan W. Miller; Evangelos Gragoudas; Demetrios Vavvas

Tags: antibodies, buffers, diabetes mellitus, enzyme-linked immunosorbent assay, eye

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1677-1682. doi:https://doi.org/10.1167/iovs.09-4193

A Novel Nonradioactive Method to Evaluate Vascular Barrier Breakdown and Leakage Free

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George Trichonas; Akrivi Manola; Yuki Morizane; Aristomenis Thanos; Xanthi Koufomichali; Thanos D. Papakostas; Sandra Montezuma; Lucy Young; Joan W. Miller; Evangelos Gragoudas; Demetrios Vavvas

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1677-1682. doi:https://doi.org/10.1167/iovs.09-4193

Retinal Glial (Müller) Cells: Sensing and Responding to Tissue Stretch Free

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Niclas Lindqvist; Qing Liu; Joachim Zajadacz; Kristian Franze; Andreas Reichenbach

Tags: body tissue, retina, stress, mechanical, fibroblast growth factor 2, calcium

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1683-1690. doi:https://doi.org/10.1167/iovs.09-4159

Noninvasive Visualization and Analysis of Parafoveal Capillaries in Humans Free

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Johnny Tam; Joy A. Martin; Austin Roorda

Tags: blood capillaries, parafoveal region

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1691-1698. doi:https://doi.org/10.1167/iovs.09-4483

Retinal Cell Biology

Increased Synthesis of Leukotrienes in the Mouse Model of Diabetic Retinopathy Free

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Ramaprasad Talahalli; Simona Zarini; Nader Sheibani; Robert C. Murphy; Rose A. Gubitosi-Klug

Tags: diabetic retinopathy, leukotriene b4, leukotrienes, mice, diabetes mellitus

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1699-1708. doi:https://doi.org/10.1167/iovs.09-3557

Role of IL-6 in Angiotensin II–Induced Retinal Vascular Inflammation Free

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Modesto Rojas; Wenbo Zhang; Dexter L. Lee; Maritza J. Romero; Doan T. Nguyen; Mohamed Al-Shabrawey; Nai-Tse Tsai; Gregory I. Liou; Michael W. Brands; Robert W. Caldwell; Ruth B. Caldwell

Tags: angiotensin ii, inflammation, interleukin-6, mice

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1709-1718. doi:https://doi.org/10.1167/iovs.09-3375

Developmental Changes of Cone Opsin Expression but Not Retinal Morphology in the Hypothyroid Pax8 Knockout Mouse Free

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Anika Glaschke; Martin Glösmann; Leo Peichl

Tags: hypothyroidism, mice, opsin, retinal cone, retina

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1719-1727. doi:https://doi.org/10.1167/iovs.09-3592

Effect of G Protein–Coupled Receptor Kinase 1 (Grk1) Overexpression on Rod Photoreceptor Cell Viability Free

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Tiffany Whitcomb; Keisuke Sakurai; Bruce M. Brown; Joyce E. Young; Lowell Sheflin; Cynthia Dlugos; Cheryl M. Craft; Vladimir J. Kefalov; Shahrokh C. Khani

Tags: g-protein-coupled receptor kinases, mice, protein overexpression, retina, rhodopsin

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1728-1737. doi:https://doi.org/10.1167/iovs.09-4499

Restricted Localization of Ponli, a Novel Zebrafish MAGUK-Family Protein, to the Inner Segment Interface Areas between Green, Red, and Blue Cones Free

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Jian Zou; Xiaojun Yang; Xiangyun Wei

Tags: family, proteins, retinal cone, zebrafish, photoreceptors

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1738-1746. doi:https://doi.org/10.1167/iovs.09-4520

Neurotrophic Effect of a Novel TrkB Agonist on Retinal Ganglion Cells Free

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Ying Hu; Seongeun Cho; Jeffrey L. Goldberg

Tags: agonists, antibodies, brain-derived neurotrophic factor, neurotrophic tyrosine kinase receptor type 2, retinal ganglion cells

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1747-1754. doi:https://doi.org/10.1167/iovs.09-4450

A Role for Omega-3 Polyunsaturated Fatty Acid Supplements in Diabetic Neuropathy Free

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Peter Yee; Anne E. Weymouth; Erica L. Fletcher; Algis J. Vingrys

Tags: diabetes mellitus, diabetes mellitus, type 2, diet, omega-3 fatty acids, rod photoreceptors

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1755-1764. doi:https://doi.org/10.1167/iovs.09-3792

Glyceraldehyde-3-Phosphate Dehydrogenase in Retinal Microvasculature: Implications for the Development and Progression of Diabetic Retinopathy Free

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Sally Madsen-Bouterse; Ghulam Mohammad; Renu A. Kowluru

Tags: diabetic retinopathy, endothelial cells, glucose, glyceraldehyde-3-phosphate dehydrogenases, retinal vasculature

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1765-1772. doi:https://doi.org/10.1167/iovs.09-4171

Defective Formation of the Inner Limiting Membrane in Laminin β2- and γ3-Null Mice Produces Retinal Dysplasia Free

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Germán Pinzón-Duarte; Gerard Daly; Yong N. Li; Manuel Koch; William J. Brunken

Tags: laminin, retina, mice, retinal dysplasia, tissue membrane

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1773-1782. doi:https://doi.org/10.1167/iovs.09-4645

Differential Roles of Matrix Metalloproteinase-9 and -2, Depending on Proliferation or Differentiation of Retinoblastoma Cells Free

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Jeong Hun Kim; Jin Hyoung Kim; Chang Sik Cho; Hyoung Oh Jun; Dong Hun Kim; Young Suk Yu; Kyu-Won Kim

Tags: gelatinase a, gelatinase b, retinoblastoma

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1783-1788. doi:https://doi.org/10.1167/iovs.09-3990

Visual Neuroscience

Expression and Biophysical Characterization of Voltage-Gated Sodium Channels in Axons and Growth Cones of the Regenerating Optic Nerve Free

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Andreas Feigenspan; Karin Dedek; Katrin Schlich; Reto Weiler; Solon Thanos

Tags: axon, biophysics, growth cones, optic nerve, voltage

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1789-1799. doi:https://doi.org/10.1167/iovs.09-4113

Clinical Trials

Effect of Dorzolamide and Timolol on Ocular Pressure: Blood Flow Relationship in Patients with Primary Open-Angle Glaucoma and Ocular Hypertension Free

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Gabriele Fuchsjäger-Mayrl; Michael Georgopoulos; Anton Hommer; Günther Weigert; Berthold Pemp; Clemens Vass; Gerhard Garhöfer; Leopold Schmetterer

Tags: dorzolamide/timolol, ocular hypertension, open-angle glaucoma, vascular flow, timolol

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1289-1296. doi:https://doi.org/10.1167/iovs.09-3827

Lecture

Introducing Samuel M. Wu, the 2009 Recipient of the Friedenwald Award Free

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Frank Werblin

Tags: awards and prizes, retina, retinal diseases

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1263. doi:https://doi.org/10.1167/iovs.09-4480

Synaptic Organization of the Vertebrate Retina: General Principles and Species-Specific VariationsThe Friedenwald Lecture Free

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Samuel M. Wu

Tags: biopharmaceutics classification system, retina, retinal cone, vertebrates, synapses

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1264-1274. doi:https://doi.org/10.1167/iovs.09-4396

Introducing Joe G. Hollyfield, the 2009 Recipient of the Proctor Medal Free

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Robert E. Anderson

Tags: eye, high schools, mothers, professors, vision

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1275. doi:https://doi.org/10.1167/iovs.09-4481

Age-Related Macular Degeneration: The Molecular Link between Oxidative Damage, Tissue-Specific Inflammation and Outer Retinal DiseaseThe Proctor Lecture Free

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Joe G. Hollyfield

Tags: age-related macular degeneration, body tissue, inflammation, retinal diseases, mice

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1276-1281. doi:https://doi.org/10.1167/iovs.09-4478

Introducing Marie E. Burns, the 2009 Recipient of the Cogan Award Free

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King-Wai Yau

Tags: awards and prizes, burns

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1282. doi:https://doi.org/10.1167/iovs.09-4479

Deactivation Mechanisms of Rod Phototransduction: The Cogan Lecture Free

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Marie E. Burns

Tags: phototransduction, recovery of function, rod photoreceptors, rhodopsin

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1283-1288. doi:https://doi.org/10.1167/iovs.09-4366

Erratum

Errata for Fleckenstein et al., Concordance of Disease Progression in Bilateral Geographic Atrophy Due to AMD Free

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Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1800. doi:https://doi.org/10.1167/iovs.09-3547a

Errata for Vitart et al., Heritabilities of Ocular Biometrical Traits in Two Croatian Isolates with Extended Pedigrees Free

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Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1800. doi:https://doi.org/10.1167/iovs.09-3720a

Obituary

Remembering Steven M. Podos, MD, 1937–2009 Free

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Oscar A. Candia

Investigative Ophthalmology & Visual Science March 2010, Vol.51, 1261-1262. doi:https://doi.org/10.1167/iovs.10-5204

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