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Anatomy and Pathology/Oncology

Regulation of Ocular Angiogenesis by Notch Signaling: Implications in Neovascular Age-Related Macular Degeneration Free
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Iqbal Ahmad; Sudha Balasubramanian; Carolina B. Del Debbio; Sowmya Parameswaran; Allen R. Katz; Carol Toris; Robert N. Fariss
Tags: angiogenesis, choroidal neovascularization, exudative age-related macular degeneration, signal transduction, regulation
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 2868-2878. doi:https://doi.org/10.1167/iovs.10-6608
Imaging Lid-Parallel Conjunctival Folds with OCT and Comparing Its Grading with the Slit Lamp Classification in Dry Eye Patients and Normal Subjects Free
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Amarilla Veres; Beáta Tapasztó; Krisztina Kosina-Hagyó; Gábor Márk Somfai; János Németh
Tags: diagnostic imaging, dry eye syndromes, slit lamps, conjunctiva, signs and symptoms
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 2945-2951. doi:https://doi.org/10.1167/iovs.10-5505
Interleukin-1β Increases Baseline Expression and Secretion of Interleukin-6 by Human Uveal Melanocytes In Vitro via the p38 MAPK/NF-κB Pathway Free
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Dan-Ning Hu; Min Chen; David Y. Zhang; Fei Ye; Steven A. McCormick; Chi-Chao Chan
Tags: bodily secretions, interleukin-6, ulnar-mammary syndrome, mitogen-activated protein kinase p38
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3767-3774. doi:https://doi.org/10.1167/iovs.10-6908

Biochemistry and Molecular Biology

Structural Organization and Expression Pattern of the Canine RPGRIP1 Isoforms in Retinal Tissue Free
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Tatyana Kuznetsova; Barbara Zangerl; Orly Goldstein; Gregory M. Acland; Gustavo D. Aguirre
Tags: body tissue, dog, domestic, exons, protein isoforms, genes
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 2989-2998. doi:https://doi.org/10.1167/iovs.10-6094
Role of miR-204 in the Regulation of Apoptosis, Endoplasmic Reticulum Stress Response, and Inflammation in Human Trabecular Meshwork Cells Free
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Guorong Li; Coralia Luna; Jianming Qiu; David L. Epstein; Pedro Gonzalez
Tags: apoptosis, endoplasmic reticulum, genes, inflammation, polymerase chain reaction
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 2999-3007. doi:https://doi.org/10.1167/iovs.10-6708
Inhibition of TGFBIp Expression by Lithium: Implications for TGFBI-Linked Corneal Dystrophy Therapy Free
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Seung-Il Choi; Bong-Yoon Kim; Shorafidinkhuja Dadakhujaev; James V. Jester; Hyunmi Ryu; Tae-im Kim; Eung Kweon Kim
Tags: cornea, fibroblasts, hereditary corneal dystrophy, lithium
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3293-3300. doi:https://doi.org/10.1167/iovs.10-6405
Inhibition of Mdm2 Sensitizes Human Retinal Pigment Epithelial Cells to Apoptosis Free
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Sujoy Bhattacharya; Ramesh M. Ray; Edward Chaum; Dianna A. Johnson; Leonard R. Johnson
Tags: apoptosis, retinal pigment cell, proteins
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3368-3380. doi:https://doi.org/10.1167/iovs.10-6991
Rod Outer Segment Retinol Formation Is Independent of Abca4, Arrestin, Rhodopsin Kinase, and Rhodopsin Palmitylation Free
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Lorie R. Blakeley; Chunhe Chen; Ching-Kang Chen; Jeannie Chen; Rosalie K. Crouch; Gabriel H. Travis; Yiannis Koutalos
Tags: arrestin, kinetics, rhodopsin, vitamin a, phosphotransferases
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3483-3491. doi:https://doi.org/10.1167/iovs.10-6694
Rod Outer Segment Retinol Formation Is Independent of Abca4, Arrestin, Rhodopsin Kinase, and Rhodopsin Palmitylation Free
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Lorie R. Blakeley; Chunhe Chen; Ching-Kang Chen; Jeannie Chen; Rosalie K. Crouch; Gabriel H. Travis; Yiannis Koutalos
Tags: arrestin, kinetics, rhodopsin, vitamin a, phosphotransferases
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3483-3491. doi:https://doi.org/10.1167/iovs.10-6694
Mitochondrial DNA Damage and Repair in RPE Associated with Aging and Age-Related Macular Degeneration Free
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Haijiang Lin; Haifeng Xu; Fong-Qi Liang; Hao Liang; Praveena Gupta; Anna N. Havey; Michael E. Boulton; Bernard F. Godley
Tags: dna, mitochondrial, retinal pigment cell, age-related macular degeneration, aging
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3521-3529. doi:https://doi.org/10.1167/iovs.10-6163
Interactive Expressions of HtrA1 and VEGF in Human Vitreous Humors and Fetal RPE Cells Free
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Tsz Kin Ng; Gary H. F. Yam; Wei Qi Chen; Vincent Y. W. Lee; Haoyu Chen; Li Jia Chen; Kwong Wai Choy; Zhenglin Yang; Chi Pui Pang
Tags: fetus, htra1 gene, retinal pigment cell, vascular endothelial growth factor a, vitreous body
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3706-3712. doi:https://doi.org/10.1167/iovs.10-6773
Deletion of the p85α Regulatory Subunit of Phosphoinositide 3-Kinase in Cone Photoreceptor Cells Results in Cone Photoreceptor Degeneration Free
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Ivana Ivanovic; Robert E. Anderson; Yun Z. Le; Steven J. Fliesler; David M. Sherry; Raju V. S. Rajala
Tags: mice, phosphoinositide 3-kinase, retinal cone, 1-phosphatidylinositol 3-kinase, tissue degeneration
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3775-3783. doi:https://doi.org/10.1167/iovs.10-7139

Clinical and Epidemiologic Research

Prevalence and Risk Factors for Refractive Errors in Indians: The Singapore Indian Eye Study (SINDI) Free
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Chen-Wei Pan; Tien-Yin Wong; Raghavan Lavanya; Ren-Yi Wu; Ying-Feng Zheng; Xiao-Yu Lin; Paul Mitchell; Tin Aung; Seang-Mei Saw
Tags: eye, myopia, prevalence, refractive errors, risk factors
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3166-3173. doi:https://doi.org/10.1167/iovs.10-6210
What Reduction in Standard Automated Perimetry Variability Would Improve the Detection of Visual Field Progression? Free
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Andrew Turpin; Allison M. McKendrick
Tags: perimetry, visual fields
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3237-3245. doi:https://doi.org/10.1167/iovs.10-6255
Determinants of Perimacular Inner Retinal Layer Thickness in Normal Eyes Measured by Fourier-Domain Optical Coherence Tomography Free
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Na Rae Kim; Ji Hyun Kim; Junwon Lee; Eun Suk Lee; Gong Je Seong; Chan Yun Kim
Tags: eye, optical coherence tomography, cornea, optic disk, demography
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3413-3418. doi:https://doi.org/10.1167/iovs.10-6648
Determinants of Macular Pigment Optical Density and Its Relation to Age-Related Maculopathy: Results from the Muenster Aging and Retina Study (MARS) Free
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Martha Dietzel; Meike Zeimer; Britta Heimes; Birte Claes; Daniel Pauleikhoff; Hans-Werner Hense
Tags: age-related macular degeneration, aging, eye, mars, motor agitation and retardation scale
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3452-3457. doi:https://doi.org/10.1167/iovs.10-6713
Test–Retest Variability of Reading Performance Metrics Using MNREAD in Patients with Age-Related Macular Degeneration Free
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Praveen J. Patel; Fred K. Chen; Lyndon Da Cruz; Gary S. Rubin; Adnan Tufail
Tags: age-related macular degeneration, performance measurement, reading (activity)
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3854-3859. doi:https://doi.org/10.1167/iovs.10-6601
Systematic Investigation of the Relationship between High Myopia and Polymorphisms of the MMP2, TIMP2, and TIMP3 Genes by a DNA Pooling Approach Free
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Kim Hung Leung; Wai Chi Yiu; Maurice K. H. Yap; Po Wah Ng; Wai Yan Fung; Pak Chung Sham; Shea Ping Yip
Tags: dna, gelatinase a, genes, myopia, single nucleotide polymorphism
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3893-3900. doi:https://doi.org/10.1167/iovs.11-7286

Cornea

Clusterin Promotes Corneal Epithelial Cell Growth through Upregulation of Hepatocyte Growth Factor by Mesenchymal Cells In Vitro Free
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Naoko Okada; Tetsuya Kawakita; Kenji Mishima; Ichiro Saito; Hideyuki Miyashita; Satoru Yoshida; Shigeto Shimmura; Kazuo Tsubota
Tags: clu gene, clusterin, cornea, corneal epithelial cells, epithelial cells
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 2905-2910. doi:https://doi.org/10.1167/iovs.10-6348
A Clinical Description of Ocular Response Analyzer Measurements Free
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William Lau; David Pye
Tags: cornea, intraocular pressure
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 2911-2916. doi:https://doi.org/10.1167/iovs.10-6763
Time-Lapse In Vivo Imaging of Corneal Angiogenesis: The Role of Inflammatory Cells in Capillary Sprouting Free
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Beatrice Bourghardt Peebo; Per Fagerholm; Catharina Traneus-Röckert; Neil Lagali
Tags: blood capillaries, corneal neovascularization, diagnostic imaging, inflammatory cells, macrophage-1 antigen
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3060-3068. doi:https://doi.org/10.1167/iovs.10-6101
Characteristics of Straylight in Normal Young Myopic Eyes and Changes before and after LASIK Free
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Jing Li; Yan Wang
Tags: eye, keratomileusis, laser in situ, postoperative care
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3069-3073. doi:https://doi.org/10.1167/iovs.10-6270
The Pharmacologic Assessment of A Novel Lymphocyte Function-Associated Antigen-1 Antagonist (SAR 1118) for the Treatment of Keratoconjunctivitis Sicca in Dogs Free
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Christopher J. Murphy; Ellison Bentley; Paul E. Miller; Kim McIntyre; Gary Leatherberry; Richard Dubielzig; Elizabeth Giuliano; Cecil P. Moore; Thomas E. Phillips; Peter B. Smith; Elizabeth Prescott; Jacqueline M. Miller; Peter Thomas; Randall Scagliotti; Doug Esson; Tom Gadek; Charles A. O'Neill
Tags: antagonists, conjunctiva, cytokine, dog, domestic, eye
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3174-3180. doi:https://doi.org/10.1167/iovs.09-5078
Role of β-Pix in Corneal Epithelial Cell Migration on Fibronectin Free
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Kazuhiro Kimura; Shinichiro Teranishi; Tomoko Orita; Hongyan Zhou; Teruo Nishida
Tags: corneal epithelial cells, fibronectins, rna, small interfering
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3181-3186. doi:https://doi.org/10.1167/iovs.10-5684
Hyperosmotic Stress-Induced Corneal Epithelial Cell Death through Activation of Polo-like Kinase 3 and c-Jun Free
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Ling Wang; Wei Dai; Luo Lu
Tags: corneal epithelial cells, stress, protein-serine-threonine kinases
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3200-3206. doi:https://doi.org/10.1167/iovs.10-6485
Changes in Corneal Biomechanics and Applanation Tonometry with Induced Corneal Swelling Free
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William Lau; David Pye
Tags: cornea, edema, eye, applanation tonometry, biomechanics
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3207-3214. doi:https://doi.org/10.1167/iovs.10-6754
Biliverdin Rescues the HO-2 Null Mouse Phenotype of Unresolved Chronic Inflammation Following Corneal Epithelial Injury Free
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Lars Bellner; Jesse Wolstein; Kiran A. Patil; Michael W. Dunn; Michal Laniado-Schwartzman
Tags: biliverdine, cornea, epithelium, wounds and injuries
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3246-3253. doi:https://doi.org/10.1167/iovs.10-6219
Identification of P2X3 and P2X7 Purinergic Receptors Activated by ATP in Rat Lacrimal Gland Free
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Robin R. Hodges; Joanna Vrouvlianis; Rachel Scott; Darlene A. Dartt
Tags: lacrimal gland, protein secretion, purinoceptor, receptors, purinergic p2x
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3254-3263. doi:https://doi.org/10.1167/iovs.10-7042
Impaired Epithelial Wound Healing and EGFR Signaling Pathways in the Corneas of Diabetic Rats Free
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Keping Xu; Fu-Shin X. Yu
Tags: cornea, diabetes mellitus, epidermal growth factor receptors, epithelium, rats
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3301-3308. doi:https://doi.org/10.1167/iovs.10-5670
Cholinergic Agonists Activate P2X7 Receptors to Stimulate Protein Secretion by the Rat Lacrimal Gland Free
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Darlene A. Dartt; Robin R. Hodges
Tags: cholinergic agonists, lacrimal gland, protein secretion, agonists, cholinergic receptors
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3381-3390. doi:https://doi.org/10.1167/iovs.11-7210
Entrapment of Conjunctival Goblet Cells by Desiccation-Induced Cornification Free
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Rosa Maria Corrales; Cintia Sade de Paiva; De-Quan Li; William Johnson Farley; Johanna Tukler Henriksson; Jan Per Gustav Bergmanson; Stephen Carl Pflugfelder
Tags: conjunctiva, desiccation, entrapment (morphologic abnormality), goblet cells, keratinization
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3492-3499. doi:https://doi.org/10.1167/iovs.10-5782
Ocular Surface Health during 30-Day Continuous Wear: Rigid Gas-Permeable versus Silicone Hydrogel Hyper-O2 Transmitted Contact Lenses Free
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Meng C. Lin; Thao N. Yeh; Andrew D. Graham; Tan Truong; Carol Hsiao; Guan Wei; Audrey Louie
Tags: contact lenses, epithelium, hydrogel, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3530-3538. doi:https://doi.org/10.1167/iovs.10-6025
Corneal Thickness Changes in Hyperopic Orthokeratology Measured by Optical Pachometry Free
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Paul Gifford; Ahmed Alharbi; Helen A. Swarbrick
Tags: cornea, lens (device), lens, crystalline, orthokeratology, optics
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3648-3653. doi:https://doi.org/10.1167/iovs.10-6323
Simulation of the Impact of Refractive Surgery Ablative Laser Pulses with a Flying-Spot Laser Beam on Intrasurgery Corneal Temperature Free
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Mario Shraiki; Samuel Arba-Mosquera
Tags: cornea, lasers, surgical ocular refractive procedure, temperature, ablation
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3713-3722. doi:https://doi.org/10.1167/iovs.10-6706
Topographic Thickness of Bowman's Layer Determined by Ultra-High Resolution Spectral Domain–Optical Coherence Tomography Free
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Aizhu Tao; Jianhua Wang; Qi Chen; Meixiao Shen; Fan Lu; Sander R. Dubovy; Mohamed Abou Shousha
Tags: bowman's layer, cornea, optical coherence tomography, epithelium, meridians
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3901-3907. doi:https://doi.org/10.1167/iovs.09-4748

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Functional Imaging of Human Extraocular Muscles In Head Tilt Dependent Hypertropia Free
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Joseph L. Demer; Jennifer Kung; Robert A. Clark
Tags: functional imaging, hypertropia, magnetic resonance imaging, muscle of orbit, orbit
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3023-3031. doi:https://doi.org/10.1167/iovs.10-6596
Spontaneous Interblink Time Distributions in Patients with Graves' Orbitopathy and Normal Subjects Free
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Denny Garcia; Carolina Trindade Pinto; José Carlos Barbosa; Antonio A. V. Cruz
Tags: blinking, artifacts
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3419-3424. doi:https://doi.org/10.1167/iovs.10-7060
Oscillatory Eye Movements Resembling Pendular Nystagmus in Normal Juvenile Macaques Free
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Natsuko Shichinohe; Graham Barnes; Teppei Akao; Sergei Kurkin; Junko Fukushima; Manabu Kase; R. John Leigh; Tim Belton; Kikuro Fukushima
Tags: cercopithecidae, child, eye movement, pendular nystagmus, velocity
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3458-3467. doi:https://doi.org/10.1167/iovs.10-5903
The Effect of Lens-Induced Anisometropia on Accommodation and Vergence during Human Visual Development Free
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Shrikant R. Bharadwaj; T. Rowan Candy
Tags: anisometropia, lens (device), lens, crystalline, visual accommodation, eye
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3595-3603. doi:https://doi.org/10.1167/iovs.10-6214
Occlusive IOLs for Intractable Diplopia Demonstrate a Novel Near-Infrared Window of Transmission for SLO/OCT Imaging and Clinical Assessment Free
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Imran H. Yusuf; Stuart N. Peirson; C. K. Patel
Tags: diagnostic imaging, diplopia, lens (device), lens, crystalline, eye
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3737-3743. doi:https://doi.org/10.1167/iovs.10-6767
Heartbeat-Induced Axial Motion Artifacts in Optical Coherence Tomography Measurements of the Retina Free
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Roy de Kinkelder; Jeroen Kalkman; Dirk J. Faber; Olaf Schraa; Pauline H. B. Kok; Frank D. Verbraak; Ton G. van Leeuwen
Tags: artifacts, motion, optical coherence tomography, retina, diagnostic imaging
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3908-3913. doi:https://doi.org/10.1167/iovs.10-6738

Genetics

Screening of SPATA7 in Patients with Leber Congenital Amaurosis and Severe Childhood-Onset Retinal Dystrophy Reveals Disease-Causing Mutations Free
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Donna S. Mackay; Louise A. Ocaka; Arundhati Dev Borman; Panagiotis I. Sergouniotis; Robert H. Henderson; Phillip Moradi; Anthony G. Robson; Dorothy A. Thompson; Andrew R. Webster; Anthony T. Moore
Tags: child, leber's amaurosis, mutation, retinal dystrophies, screening
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3032-3038. doi:https://doi.org/10.1167/iovs.10-7025
Copy Number Variations in Candidate Genes in Neovascular Age-Related Macular Degeneration Free
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Melissa M. Liu; Elvira Agrón; Emily Chew; Catherine Meyerle; Frederick L. Ferris, III; Chi-Chao Chan; Jingsheng Tuo
Tags: candidate disease gene, copy number polymorphism, exudative age-related macular degeneration, genes, dna
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3129-3135. doi:https://doi.org/10.1167/iovs.10-6735
A Novel Locus for Congenital Simple Microphthalmia Family Mapping to 17p12-q12 Free
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Zhengmao Hu; Changhong Yu; Jingzhi Li; Yiqiang Wang; Deyuan Liu; Xinying Xiang; Wei Su; Qian Pan; Lixin Xie; Kun Xia
Tags: family, microphthalmos, haplotypes, genome
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3425-3429. doi:https://doi.org/10.1167/iovs.10-6747
A Functional Polymorphism at 3′UTR of the PAX6 Gene May Confer Risk for Extreme Myopia in the Chinese Free
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Chung-Ling Liang; Edward Hsi; Ku-Chung Chen; Yun-Ru Pan; Yung-Song Wang; Suh-Hang Hank Juo
Tags: chinese (other dialects), chinese people, genes, myopia, polymorphism
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3500-3505. doi:https://doi.org/10.1167/iovs.10-5859
Cellular Expression and siRNA-Mediated Interference of Rhodopsin cis-Acting Splicing Mutants Associated with Autosomal Dominant Retinitis Pigmentosa Free
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Imma Hernan; María José Gamundi; Ester Planas; Emma Borràs; Miquel Maseras; Miguel Carballo
Tags: proteins, retinitis pigmentosa, rhodopsin, rna splicing, rna, small interfering
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3723-3729. doi:https://doi.org/10.1167/iovs.10-6933
Vitamin D Receptor (VDR) and Group-Specific Component (GC, Vitamin D–Binding Protein) Polymorphisms in Myopia Free
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Donald O. Mutti; Margaret E. Cooper; Ecaterina Dragan; Lisa A. Jones-Jordan; Melissa D. Bailey; Mary L. Marazita; Jeffrey C. Murray; Karla Zadnik; the CLEERE Study Group
Tags: myopia, polymorphism, vitamin d3 receptor, vitamin d-binding protein, single nucleotide polymorphism
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3818-3824. doi:https://doi.org/10.1167/iovs.10-6534

Glaucoma

Distortion of Axonal Cytoskeleton: An Early Sign of Glaucomatous Damage Free
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Xiangrun Huang; Wei Kong; Ye Zhou; Giovanni Gregori
Tags: actins, cytoskeleton, glaucoma, retina, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 2879-2888. doi:https://doi.org/10.1167/iovs.10-5929
Elasticity-Dependent Modulation of TGF-β Responses in Human Trabecular Meshwork Cells Free
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Hong Han; Thomas Wecker; Franz Grehn; Günther Schlunck
Tags: elasticity, proteins, trabecular meshwork, extracellular matrix, gel
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 2889-2896. doi:https://doi.org/10.1167/iovs.10-6640
Dexamethasone-Associated Cross-Linked Actin Network Formation in Human Trabecular Meshwork Cells Involves β3 Integrin Signaling Free
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Mark S. Filla; Marie K. Schwinn; Amanda K. Nosie; Ross W. Clark; Donna M. Peters
Tags: dexamethasone, integrins, actins, signal transduction, trabecular meshwork
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 2952-2959. doi:https://doi.org/10.1167/iovs.10-6618
Dynamic Imaging of Axonal Transport in Living Retinal Ganglion Cells In Vitro Free
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Yuji Takihara; Masaru Inatani; Hideki Hayashi; Naoki Adachi; Keiichiro Iwao; Toshihiro Inoue; Minako Iwao; Hidenobu Tanihara
Tags: axonal transport, brain-derived neurotrophic factor, diagnostic imaging, retinal ganglion cells, axon
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3039-3045. doi:https://doi.org/10.1167/iovs.10-6435
Evaluation of Pirfenidone as a New Postoperative Antiscarring Agent in Experimental Glaucoma Surgery Free
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Hua Zhong; Guoying Sun; Xianchai Lin; Kaili Wu; Minbin Yu
Tags: blister, glaucoma surgery, pirfenidone, postoperative care, surgical procedures, operative
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3136-3142. doi:https://doi.org/10.1167/iovs.10-6240
Use of an Adult Rat Retinal Explant Model for Screening of Potential Retinal Ganglion Cell Neuroprotective Therapies Free
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Natalie D. Bull; Thomas V. Johnson; Guncha Welsapar; Nicholas W. DeKorver; Stanislav I. Tomarev; Keith R. Martin
Tags: adult, neuroprotection, retinal ganglion cells, screening, pharmaceutical preparations
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3309-3320. doi:https://doi.org/10.1167/iovs.10-6873
Coordinated Regulation of Extracellular Matrix Synthesis by the MicroRNA-29 Family in the Trabecular Meshwork Free
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Guadalupe Villarreal, Jr; Dong-Jin Oh; Min Hyung Kang; Douglas J. Rhee
Tags: extracellular matrix, family, micrornas, mir29a gene, regulation
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3391-3397. doi:https://doi.org/10.1167/iovs.10-6165
Lack of Association between Glaucoma and Macular Choroidal Thickness Measured with Enhanced Depth-Imaging Optical Coherence Tomography Free
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Jean-Claude Mwanza; Jessica T. Hochberg; Michael R. Banitt; William J. Feuer; Donald L. Budenz
Tags: diagnostic imaging, glaucoma, optical coherence tomography
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3430-3435. doi:https://doi.org/10.1167/iovs.10-6600
Ocular Pathology Relevant to Glaucoma in a Gja1 Jrt/+ Mouse Model of Human Oculodentodigital Dysplasia Free
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Edmund Tsui; Kathleen A. Hill; Alex M. Laliberte; Daniel Paluzzi; Ilia Kisilevsky; Qing Shao; J. Godfrey Heathcote; Dale W. Laird; Gerald M. Kidder; Cindy M. L. Hutnik
Tags: connexin 43, glaucoma, mice, oculo-dento-digital syndrome, eye
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3539-3547. doi:https://doi.org/10.1167/iovs.10-6399
Comparison of the In Vitro Tolerance and In Vivo Efficacy of Traditional Timolol Maleate Eye Drops versus New Formulations with Bioadhesive Polymers Free
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Vanessa Andrés-Guerrero; Marta Vicario-de-la-Torre; Irene T. Molina-Martínez; José Manuel Benítez-del-Castillo; Julián García-Feijoo; Rocío Herrero-Vanrell
Tags: eyedrops, intraocular pressure, polymers, timolol, tuberculosis
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3548-3556. doi:https://doi.org/10.1167/iovs.10-6338
Cross-talk between miR-29 and Transforming Growth Factor-Betas in Trabecular Meshwork Cells Free
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Coralia Luna; Guorong Li; Jianming Qiu; David L. Epstein; Pedro Gonzalez
Tags: genes, polymerase chain reaction, trabecular meshwork, transfection, down-regulation
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3567-3572. doi:https://doi.org/10.1167/iovs.10-6448
Postnatal Elongation of Eye Size in DBA/2J Mice Compared with C57BL/6J Mice: In Vivo Analysis with Whole-Eye OCT Free
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Tsung-Han Chou; Omer P. Kocaoglu; David Borja; Marco Ruggeri; Stephen R. Uhlhorn; Fabrice Manns; Vittorio Porciatti
Tags: eye, mice, mice, inbred c57bl, intraocular pressure
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3604-3612. doi:https://doi.org/10.1167/iovs.10-6340
Quantification of Deficits in Spatial Visual Function of Mouse Models for Glaucoma Free
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Stephanie L. Burroughs; Simon Kaja; Peter Koulen
Tags: glaucoma, intraocular pressure, mice, vision, contrast sensitivity
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3654-3659. doi:https://doi.org/10.1167/iovs.10-7106
Connective Tissue Growth Factor Is Increased in Pseudoexfoliation Glaucoma Free
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John G. Browne; Su Ling Ho; Rosemary Kane; Noelynn Oliver; Abbot. F. Clark; Colm J. O'Brien; John K. Crean
Tags: connective tissue growth factor, exfoliation syndrome
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3660-3666. doi:https://doi.org/10.1167/iovs.10-5209
The Effect of Induced Intraocular Straylight on Perimetric Tests Free
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Ciara Bergin; Tony Redmond; Neil Nathwani; Gay Mary Verdon-Roe; David P. Crabb; Roger S. Anderson; David F. Garway-Heath
Tags: cataract, perimetry, filters
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3676-3682. doi:https://doi.org/10.1167/iovs.10-6642
Comparing Corneal Variables in Healthy Subjects and Patients with Primary Open-Angle Glaucoma Free
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Federico Saenz-Frances; Julian Garcia-Feijó; Luis Jañez; Lara Borrego-Sanz; Jose M. Martinez de la Casa; Ana Fernandez-Vidal; Carmen Mendez-Hernández; Enrique Santos-Bueso; Juan Reche-Frutos; Julian Garcia-Sánchez
Tags: cornea, open-angle glaucoma, glaucoma
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3683-3688. doi:https://doi.org/10.1167/iovs.10-6660
Low-Luminance Contrast Stimulation Is Optimal for Early Detection of Glaucoma Using Multifocal Visual Evoked Potentials Free
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Hemamalini Arvind; Alexander Klistorner; John Grigg; Stuart L. Graham
Tags: evoked potentials, visual, glaucoma, luminance, early diagnosis, human leukocyte antigens
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3744-3750. doi:https://doi.org/10.1167/iovs.10-6057

Immunology and Microbiology

Topical Flagellin-Mediated Innate Defense against Candida albicans Keratitis Free
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Nan Gao; Ashok Kumar; Hui Guo; Xinyi Wu; Michelle Wheater; Fu-Shin X. Yu
Tags: cornea, flagellin, keratitis, mice
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3074-3082. doi:https://doi.org/10.1167/iovs.10-5928
NKT Cell Exacerbation of Liver Metastases Arising from Melanomas Transplanted into Either the Eyes or Spleens of Mice Free
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Wanhua Yang; Haochuan Li; Elizabeth Mayhew; Jessamee Mellon; Peter W. Chen; Jerry Y. Niederkorn
Tags: liver, liver metastases, melanoma, mice, natural killer cells
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3094-3102. doi:https://doi.org/10.1167/iovs.10-7067
Mesenchymal Stem Cells Ameliorate Experimental Autoimmune Uveoretinitis by Comprehensive Modulation of Systemic Autoimmunity Free
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Xiaomin Zhang; Xinjun Ren; Guangda Li; Chunna Jiao; Lei Zhang; Shaozhen Zhao; Jiantao Wang; Zhong Chao Han; Xiaorong Li
Tags: autoimmunity, cytokine, immunization, mesenchymal stem cells, rats
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3143-3152. doi:https://doi.org/10.1167/iovs.10-6334
Role of Wall Teichoic Acids in Staphylococcus aureus Endophthalmitis Free
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Takashi Suzuki; Jennifer Campbell; Jonathan G. Swoboda; Suzanne Walker; Michael S. Gilmore
Tags: endophthalmitis, staphylococcus aureus, teichoic acids, vitreous body, killing
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3187-3192. doi:https://doi.org/10.1167/iovs.10-6558
Pharmacological Cholinergic Blockade Stimulates Inflammatory Cytokine Production and Lymphocytic Infiltration in the Mouse Lacrimal Gland Free
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John D. Pitcher, III; Cintia S. De Paiva; Flavia S. A. Pelegrino; Andrew J. McClellan; Jagdeep K. Raince; Solherny B. Pangelinan; Ehsan Rahimy; William J. Farley; Michael E. Stern; De-Quan Li; Stephen C. Pflugfelder
Tags: cholinergic agents, cytokine, lacrimal gland, mice, pharmacology
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3221-3227. doi:https://doi.org/10.1167/iovs.09-4212
Blockade of Interleukin-6 Signaling Suppresses Not Only Th17 but Also Interphotoreceptor Retinoid Binding Protein–Specific Th1 by Promoting Regulatory T Cells in Experimental Autoimmune U... Free
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Hiroshi Haruta; Nobuyuki Ohguro; Minoru Fujimoto; Satoshi Hohki; Fumitaka Terabe; Satoshi Serada; Shintaro Nomura; Kohji Nishida; Tadamitsu Kishimoto; Tetsuji Naka
Tags: autoimmune diseases, inflammation, interleukin-6, mice, regulatory t-lymphocytes
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3264-3271. doi:https://doi.org/10.1167/iovs.10-6272
Engagement of TLR2 Reverses the Suppressor Function of Conjunctiva CD4+CD25+ Regulatory T Cells and Promotes Herpes Simplex Virus Epitope-Specific CD4+CD25− Effector T Cell Responses Free
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Gargi Dasgupta; Aziz Alami Chentoufi; Sylvaine You; Payam Falatoonzadeh; Lourie Ann A. Urbano; Ayesha Akhtarmalik; Kimberly Nguyen; Lilit Ablabutyan; Anthony B. Nesburn; Lbachir BenMohamed
Tags: antigens, cd25, conjunctiva, ligands, toll-like receptor 2, t-lymphocytes
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3321-3333. doi:https://doi.org/10.1167/iovs.10-6522
Upregulation of Antibody Response to Heat Shock Proteins and Tissue Antigens in an Ocular Ischemia Model Free
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Stephanie C. Joachim; Martin B. Wax; Nils Boehm; Desiree R. Dirk; Norbert Pfeiffer; Franz H. Grus
Tags: antibodies, antibody formation, antigens, body tissue, heat-shock proteins
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3468-3474. doi:https://doi.org/10.1167/iovs.10-5763
Punctate Inner Choroidopathy and Multifocal Choroiditis with Panuveitis Share Haplotypic Associations with IL10 and TNF Loci Free
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Denize Atan; Samantha Fraser-Bell; Jarka Plskova; Lucia Kuffová; Aideen Hogan; Adnan Tufail; Dara J. Kilmartin; John V. Forrester; Jeff L. Bidwell; Andrew D. Dick; Amanda J. Churchill
Tags: choroid diseases, choroiditis, interleukin-10, panuveitis, syndrome
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3573-3581. doi:https://doi.org/10.1167/iovs.10-6743

Lens

A Class I (Senofilcon A) Soft Contact Lens Prevents UVB-Induced Ocular Effects, Including Cataract, in the Rabbit In Vivo Free
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Frank J. Giblin; Li-Ren Lin; Victor R. Leverenz; Loan Dang
Tags: cataract, contact lenses, hydrophilic, lens (device), lens, crystalline, oryctolagus cuniculus
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3667-3675. doi:https://doi.org/10.1167/iovs.10-6885
Intermediate Filaments Regulate Tissue Size and Stiffness in the Murine Lens Free
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Douglas S. Fudge; John V. McCuaig; Shannon Van Stralen; John F. Hess; Huan Wang; Richard T. Mathias; Paul G. FitzGerald
Tags: lens (device), lens, crystalline, body tissue, intermediate filaments
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3860-3867. doi:https://doi.org/10.1167/iovs.10-6231

Low Vision

The Impact of Vision Impairment on Vision-Specific Quality of Life in Germany Free
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Robert P. Finger; Eva Fenwick; Manjula Marella; Mohammed Dirani; Frank G. Holz; Peggy Pei-Chia Chiang; Ecosse L. Lamoureux
Tags: german, germany, quality of life, vision, visual impairment
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3613-3619. doi:https://doi.org/10.1167/iovs.10-7127

Multidisciplinary Ophthalmic Imaging

Noninvasive Topical Loading for Manganese-Enhanced MRI of the Mouse Visual System Free
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Shu-Wei Sun; Bruce Campbell; Chantal Lunderville; Eric Won; Hsiao-Fang Liang
Tags: administration, topical, eye, magnetic resonance imaging, manganese, mice
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3914-3920. doi:https://doi.org/10.1167/iovs.10-6363

Nantotechnology and Regenerative Medicine

Characterization of Ocular Tissues Using Microindentation and Hertzian Viscoelastic Models Free
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Lawrence Yoo; Jason Reed; Andrew Shin; Jennifer Kung; James K. Gimzewski; Vadims Poukens; Robert A. Goldberg; Ronald Mancini; Mehryar Taban; Ronald Moy; Joseph L. Demer
Tags: body tissue, cattle, immune reconstitution inflammatory syndrome
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3475-3482. doi:https://doi.org/10.1167/iovs.10-6867

Physiology and Pharmacology

Treatment of Experimental Anterior and Intermediate Uveitis by a Dexamethasone Intravitreal Implant Free
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Corine R. Ghosn; Yong Li; Werhner C. Orilla; Ton Lin; Larry Wheeler; James A. Burke; Michael R. Robinson; Scott M. Whitcup
Tags: dexamethasone, eye, histopathology tests, implants, inflammation
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 2917-2923. doi:https://doi.org/10.1167/iovs.10-5939
VEGF-Induced Retinal Angiogenic Signaling Is Critically Dependent on Ca2+ Signaling by Ca2+/Calmodulin-Dependent Protein Kinase II Free
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Elayappan Banumathi; Anna O'Connor; Sangiliyandi Gurunathan; David A. Simpson; J. Graham McGeown; Tim M. Curtis
Tags: angiogenesis, vascular endothelial growth factor a, signal transduction, calcium-calmodulin-dependent protein kinases, calmodulin
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3103-3111. doi:https://doi.org/10.1167/iovs.10-6574
Cellular Localization of Glutamate and Glutamine Metabolism and Transport Pathways in the Rat Ciliary Epithelium Free
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Rebecca G. Hu; Julie C. Lim; Michael Kalloniatis; Paul J. Donaldson
Tags: ciliary epithelium, glutamate, glutamates, glutamine, biological transport
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3345-3353. doi:https://doi.org/10.1167/iovs.10-6422
The Role of the Prostaglandin EP4 Receptor in the Regulation of Human Outflow Facility Free
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Lindsay H. Millard; David F. Woodward; W. Daniel Stamer
Tags: agonists, cyclic amp, eye, prostaglandins, regulation
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3506-3513. doi:https://doi.org/10.1167/iovs.10-6510
Sonoporation Enhances Chemotherapeutic Efficacy in Retinoblastoma Cells In Vitro Free
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Nahyoung G. Lee; Jesse L. Berry; Tom C. Lee; Annie T. Wang; Scott Honowitz; A. Linn Murphree; Neeta Varshney; David R. Hinton; Amani A. Fawzi
Tags: cell survival, chemotherapy regimen, doxorubicin, retinoblastoma, ultrasonography
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3868-3873. doi:https://doi.org/10.1167/iovs.10-6501
Endothelin 1 Stimulates Ca2+-Sparks and Oscillations in Retinal Arteriolar Myocytes via IP3R and RyR-Dependent Ca2+ Release Free
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James Tumelty; Kevin Hinds; Peter Bankhead; Neil J. McGeown; C. Norman Scholfield; Tim M. Curtis; J. Graham McGeown
Tags: arteriole, endothelin-1, muscle cells, ryanodine receptors, signal transduction
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3874-3879. doi:https://doi.org/10.1167/iovs.10-6029

Retina

Naloxone Ameliorates Retinal Lesions in Ccl2/Cx3cr1 Double-Deficient Mice via Modulation of Microglia Free
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Defen Shen; Xiaoguang Cao; Lian Zhao; Jingsheng Tuo; Wai T. Wong; Chi-Chao Chan
Tags: mice, microglia, monocyte chemoattractant protein-1, naloxone
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 2897-2904. doi:https://doi.org/10.1167/iovs.10-6114
Intraocular Toxicity and Pharmacokinetics of Candesartan in a Rabbit Model Free
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Ji Eun Lee; Dae Won Lim; Hyun Jun Park; Jong Hun Shin; Seung Min Lee; Boo Sup Oum
Tags: candesartan cilexetil, oryctolagus cuniculus, pharmacokinetics, toxic effect, eye
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 2924-2929. doi:https://doi.org/10.1167/iovs.10-5850
Smad4 Is Required Predominantly in the Developmental Processes Dependent on the BMP Branch of the TGF-β Signaling System in the Embryonic Mouse Retina Free
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Deepa Murali; Motoko Kawaguchi-Niida; Chu-Xia Deng; Yasuhide Furuta
Tags: embryo, mice, retina, signal transduction, smad4 gene
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 2930-2937. doi:https://doi.org/10.1167/iovs.10-5940
Knockdown of the Zebrafish Ortholog of the Retinitis Pigmentosa 2 (RP2) Gene Results in Retinal Degeneration Free
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Xinhua Shu; Zhiqiang Zeng; Philippe Gautier; Alan Lennon; Milica Gakovic; Michael E. Cheetham; E. Elizabeth Patton; Alan F. Wright
Tags: genes, retinal degeneration, retinitis pigmentosa, zebrafish, phenotype
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 2960-2966. doi:https://doi.org/10.1167/iovs.10-6800
Computational Quantification of Complex Fundus Phenotypes in Age-Related Macular Degeneration and Stargardt Disease Free
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Gwenole Quellec; Stephen R. Russell; Todd E. Scheetz; Edwin M. Stone; Michael D. Abràmoff
Tags: age-related macular degeneration, drusen, phenotype, pixel, stargardt's disease
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 2976-2981. doi:https://doi.org/10.1167/iovs.10-6232
Response of Retinal Vessels and Retrobulbar Hemodynamics to Intravitreal Anti-VEGF Treatment in Eyes with Branch Retinal Vein Occlusion Free
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Stefan Sacu; Berthold Pemp; Günther Weigert; Gerlinde Matt; Gerhard Garhofer; Christian Pruente; Leopold Schmetterer; Ursula Schmidt-Erfurth
Tags: anti-vascular endothelial growth factor therapy, eye, hemodynamics, ranibizumab, retinal vessels
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3046-3050. doi:https://doi.org/10.1167/iovs.10-5842
Integration of a Spectral Domain Optical Coherence Tomography System into a Surgical Microscope for Intraoperative Imaging Free
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Justis P. Ehlers; Yuankai K. Tao; Sina Farsiu; Ramiro Maldonado; Joseph A. Izatt; Cynthia A. Toth
Tags: diagnostic imaging, intraoperative care, operating microscopes, optical coherence tomography, surgical procedures, operative
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3153-3159. doi:https://doi.org/10.1167/iovs.10-6720
Vasomotor Effect of Intravitreal Juxta-arteriolar Injection of l-Lactate on the Retinal Arterioles after Acute Branch Retinal Vein Occlusion in Minipigs Free
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Efstratios Mendrinos; Ioannis K. Petropoulos; Georgios Mangioris; Miltiadis K. Tsilimbaris; Domniki N. Papadopoulou; Aliki Geka; Constantin J. Pournaras
Tags: arteriole, lactates, swine, miniature, venous retinal branch occlusion, diameter
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3215-3220. doi:https://doi.org/10.1167/iovs.10-6888
A QTL on Chromosome 10 Modulates Cone Photoreceptor Number in the Mouse Retina Free
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Irene E. Whitney; Mary A. Raven; Lu Lu; Robert W. Williams; Benjamin E. Reese
Tags: mice, quantitative trait loci, retina, retinal cone, chromosomes, human, pair 10
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3228-3236. doi:https://doi.org/10.1167/iovs.10-6693
Validation of the National Eye Institute Visual Function Questionnaire-25 (NEI VFQ-25) in Age-Related Macular Degeneration Free
PDF
Peggy Orr; Anne M. Rentz; Mary Kay Margolis; Dennis A. Revicki; Chantal M. Dolan; Shoshana Colman; Jennifer T. Fine; Neil M. Bressler
Tags: age-related macular degeneration, contrast sensitivity, eye, questionnaires, reading speed
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3354-3359. doi:https://doi.org/10.1167/iovs.10-5645
Decreased Circulation in the Feline Choriocapillaris Underlying Retinal Photocoagulation Lesions Free
PDF
Christine J. Lee; Jennifer H. Smith; Jennifer J. Kang-Mieler; Ewa Budzynski; Robert A. Linsenmeier
Tags: adaptive testing, cats, light coagulation, microspheres, retina
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3398-3403. doi:https://doi.org/10.1167/iovs.10-6560
Expression of Complement Component 3 (C3) from an Adenovirus Leads to Pathology in the Murine Retina Free
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Siobhan M. Cashman; Akshata Desai; Kasmir Ramo; Rajendra Kumar-Singh
Tags: adenoviruses, complement 3, eye, retina, mice
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3436-3445. doi:https://doi.org/10.1167/iovs.10-6002
Focal Macular Electroretinogram in Macular Edema Secondary to Central Retinal Vein Occlusion Free
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Ken Ogino; Akitaka Tsujikawa; Hajime Nakamura; Kazuaki Miyamoto; Tomoaki Murakami; Yuki Muraoka; Yumiko Kurashige; Nagahisa Yoshimura
Tags: central retinal vein occlusion, edema, electroretinography, eye
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3514-3520. doi:https://doi.org/10.1167/iovs.10-7142
Early-Onset, Slow Progression of Cone Photoreceptor Dysfunction and Degeneration in CNG Channel Subunit CNGB3 Deficiency Free
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Jianhua Xu; Lynsie Morris; Steven J. Fliesler; David M. Sherry; Xi-Qin Ding
Tags: mice, pathophysiology, retinal cone, tissue degeneration, opsin
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3557-3566. doi:https://doi.org/10.1167/iovs.10-6358
Response of Retinal Connexin43 to Optic Nerve Injury Free
PDF
Shenton S. L. Chew; Cameron S. Johnson; Colin R. Green; Helen V. Danesh-Meyer
Tags: connexin 43, optic nerve injuries, wounds and injuries
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3620-3629. doi:https://doi.org/10.1167/iovs.10-6318
Expression and Iron-Dependent Regulation of Succinate Receptor GPR91 in Retinal Pigment Epithelium Free
PDF
Jaya P. Gnana-Prakasam; Sudha Ananth; Puttur D. Prasad; Ming Zhang; Sally S. Atherton; Pamela M. Martin; Sylvia B. Smith; Vadivel Ganapathy
Tags: cytomegalovirus infections, iron, mice, regulation, retina
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3751-3758. doi:https://doi.org/10.1167/iovs.10-6722
A Potential Role for Angiopoietin 2 in the Regulation of the Blood–Retinal Barrier in Diabetic Retinopathy Free
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Sampathkumar Rangasamy; Ramprasad Srinivasan; Joann Maestas; Paul G. McGuire; Arup Das
Tags: angiopoietins, blood-retinal barrier, cadherins, diabetes mellitus, diabetic retinopathy
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3784-3791. doi:https://doi.org/10.1167/iovs.10-6386
Edaravone, an ROS Scavenger, Ameliorates Photoreceptor Cell Death after Experimental Retinal Detachment Free
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Mi In Roh; Yusuke Murakami; Aristomenis Thanos; Demetrios G. Vavvas; Joan W. Miller
Tags: photoreceptors, retina, retinal detachment, monocyte chemoattractant protein-1, caspases
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3825-3831. doi:https://doi.org/10.1167/iovs.10-6797
In Vivo Evaluation of Laser-Induced Choroidal Neovascularization Using Spectral-Domain Optical Coherence Tomography Free
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Andrea Giani; Aristomenis Thanos; Mi In Roh; Edward Connolly; George Trichonas; Ivana Kim; Evangelos Gragoudas; Demetrios Vavvas; Joan W. Miller
Tags: choroidal neovascularization, lasers, optical coherence tomography
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3880-3887. doi:https://doi.org/10.1167/iovs.10-6266

Retinal Cell Biology

Differential Effects of Rapamycin on Rods and Cones During Light-Induced Stress in Albino Mice Free
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Kannan Kunchithapautham; Beth Coughlin; John J. Lemasters; Bärbel Rohrer
Tags: rapamycin, mice, stress, albinism, photoreceptors, vertebrate
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 2967-2975. doi:https://doi.org/10.1167/iovs.10-6278
Dicer Plays Essential Roles for Retinal Development by Regulation of Survival and Differentiation Free
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Atsumi Iida; Toru Shinoe; Yukihiro Baba; Hiroyuki Mano; Sumiko Watanabe
Tags: antigens, differentiation, apoptosis, electroporation, immunohistochemistry, mice
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3008-3017. doi:https://doi.org/10.1167/iovs.10-6428
A Novel Specific Application of Pyruvate Protects the Mouse Retina against White Light Damage: Differential Stabilization of HIF-1α and HIF-2α Free
PDF
Hao Ren; Ning-Yu Liu; Xiao-Feng Song; Yun-Sheng Ma; Xiao-Yue Zhai
Tags: pyruvates, retina, stabilization, mice, white light
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3112-3118. doi:https://doi.org/10.1167/iovs.10-5605
The Loss of Vacuolar Protein Sorting 11 (vps11) Causes Retinal Pathogenesis in a Vertebrate Model of Syndromic Albinism Free
PDF
Jennifer L. Thomas; Thomas S. Vihtelic; Aaron D. denDekker; Gregory Willer; Xixia Luo; Taylor R. Murphy; Ronald G. Gregg; David R. Hyde; Ryan Thummel
Tags: albinism, platinum, proteins, zebrafish, vacuole
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3119-3128. doi:https://doi.org/10.1167/iovs.10-5957
Activation of Formyl Peptide Receptor-1 Enhances Restitution of Human Retinal Pigment Epithelial Cell Monolayer under Electric Fields Free
PDF
Xiao-Guang Zhang; Yan-Nian Hui; Xiao-Feng Huang; Hong-Jun Du; Jian Zhou; Ji-Xian Ma
Tags: fetal restitution, osteopathic manipulation, facilitated positional release, peptides, retinal pigment cell, rna, messenger
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3160-3165. doi:https://doi.org/10.1167/iovs.10-5156
Suppression of Choroidal Neovascularization and Quantitative and Qualitative Inhibition of VEGF and CCL2 by Heparin Free
PDF
Daisuke Tomida; Koji M. Nishiguchi; Keiko Kataoka; Tetsuhiro R. Yasuma; Eiji Iwata; Ruka Uetani; Shu Kachi; Hiroko Terasaki
Tags: choroidal neovascularization, heparin, monocyte chemoattractant protein-1, vascular endothelial growth factor a, lasers
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3193-3199. doi:https://doi.org/10.1167/iovs.10-6737
Suppression of Choroidal Neovascularization by Vasohibin-1, a Vascular Endothelium–Derived Angiogenic Inhibitor Free
PDF
Ryosuke Wakusawa; Toshiaki Abe; Hajime Sato; Hikaru Sonoda; Masaaki Sato; Yuuichi Mitsuda; Tomoaki Takakura; Tomi Fukushima; Hideyuki Onami; Nobuhiro Nagai; Yumi Ishikawa; Kohji Nishida; Yasufumi Sato
Tags: choroidal neovascularization, lasers, eye, angiogenesis, mice
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3272-3280. doi:https://doi.org/10.1167/iovs.10-6295
Effects of Ischemia–Reperfusion on Physiological Properties of Müller Glial Cells in the Porcine Retina Free
PDF
Antje Wurm; Ianors Iandiev; Susann Uhlmann; Peter Wiedemann; Andreas Reichenbach; Andreas Bringmann; Thomas Pannicke
Tags: ischemia, neuroglia, physiologic reperfusion, reperfusion therapy, retina
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3360-3367. doi:https://doi.org/10.1167/iovs.10-6901
Photobiomodulation Protects the Retina from Light-Induced Photoreceptor Degeneration Free
PDF
Rizalyn Albarracin; Janis Eells; Krisztina Valter
Tags: photoreceptors, retina, tissue degeneration
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3582-3592. doi:https://doi.org/10.1167/iovs.10-6664
Activation of AMP-Activated Protein Kinase Prevents Lipotoxicity in Retinal Pericytes Free
PDF
José M. Cacicedo; Sunun Benjachareonwong; Eva Chou; Norito Yagihashi; Neil B. Ruderman; Yasuo Ido
Tags: aica ribonucleotide, ampk, ceramides, palmitates, pericytes
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3630-3639. doi:https://doi.org/10.1167/iovs.10-5784
Functional Characterization of Bestrophin-1 Missense Mutations Associated with Autosomal Recessive Bestrophinopathy Free
PDF
Alice E. Davidson; Ian D. Millar; Rosemary Burgess-Mullan; Geoffrey J. Maher; Jill E. Urquhart; Peter D. Brown; Graeme C. M. Black; Forbes D. C. Manson
Tags: autosomal recessive inheritance, catabolism, missense mutation, mutation, transfection
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3730-3736. doi:https://doi.org/10.1167/iovs.10-6707
Novel Role of Mitochondrial Matrix Metalloproteinase-2 in the Development of Diabetic Retinopathy Free
PDF
Ghulam Mohammad; Renu A. Kowluru
Tags: chaperonin 60, diabetic retinopathy, gelatinase a, mitochondria, connexin 43
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3832-3841. doi:https://doi.org/10.1167/iovs.10-6368
Nicotine Increases the VEGF/PEDF Ratio in Retinal Pigment Epithelium: A Possible Mechanism for CNV in Passive Smokers with AMD Free
PDF
Marianne Pons; Maria E. Marin-Castaño
Tags: choroidal neovascularization, nicotine, retinal pigment cell, smoking, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3842-3853. doi:https://doi.org/10.1167/iovs.10-6254

Visual Neuroscience

Histamine Elevates Free Intracellular Calcium in Mouse Retinal Dopaminergic Cells via H1-Receptors Free
PDF
Renata Frazão; Douglas G. McMahon; Walter Schunack; Proleta Datta; Ruth Heidelberger; David W. Marshak
Tags: calcium, dopamine, histamine, mice
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3083-3088. doi:https://doi.org/10.1167/iovs.10-6160
Loss of the Low-Frequency Component of the Global-Flash Multifocal Electroretinogram in Primate Eyes with Experimental Glaucoma Free
PDF
Xunda Luo; Nimesh B. Patel; Ronald S. Harwerth; Laura J. Frishman
Tags: electroretinography, eye, glaucoma, optic nerve head component response, erg protein, human
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3792-3804. doi:https://doi.org/10.1167/iovs.10-6667

Visual Psychophysics and Physiological Optics

Chinese Character Recognition Using Simulated Phosphene Maps Free
PDF
Ying Zhao; Yanyu Lu; Chuanqing Zhou; Yao Chen; Qiushi Ren; Xinyu Chai
Tags: accommodation phosphene, chief complaint, chinese (other dialects), chinese people, maps
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3404-3412. doi:https://doi.org/10.1167/iovs.09-4234
Three-Dimensional Magnetic Resonance Imaging of the Phakic Crystalline Lens during Accommodation Free
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Amy L. Sheppard; C. John Evans; Krish D. Singh; James S. Wolffsohn; Mark C. M. Dunne; Leon N. Davies
Tags: 3d mri, lens, crystalline, magnetic resonance imaging, visual accommodation, lens (device)
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3689-3697. doi:https://doi.org/10.1167/iovs.10-6805

Clinical Trials

Evaluation of Retinal Function and Flicker Light-Induced Retinal Vascular Response in Normotensive Patients with Diabetes without Retinopathy Free
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Amélie Lecleire-Collet; Isabelle Audo; Mounir Aout; Jean-François Girmens; Rénata Sofroni; Ali Erginay; Jean-François Le Gargasson; Saddek Mohand-Saïd; Taly Meas; Pierre-Jean Guillausseau; Eric Vicaut; Michel Paques; Pascale Massin
Tags: diabetes mellitus, diabetes mellitus, type 2, electroretinography, photopsia, retinal diseases
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 2861-2867. doi:https://doi.org/10.1167/iovs.10-5960
Reading Rehabilitation of Individuals with AMD: Relative Effectiveness of Training Approaches Free
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William Seiple; Patricia Grant; Janet P. Szlyk
Tags: reading (activity), rehabilitation, training, reading speed
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 2938-2944. doi:https://doi.org/10.1167/iovs.10-6137
Multivariate Analyses of Inflammatory Cytokines in Eyes with Branch Retinal Vein Occlusion: Relationships to Bevacizumab Treatment Free
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Shuzo Kaneda; Dai Miyazaki; Shin-ichi Sasaki; Keiko Yakura; Yuki Terasaka; Ken-ichiro Miyake; Yoshifumi Ikeda; Taisaku Funakoshi; Takashi Baba; Atsushi Yamasaki; Yoshitsugu Inoue
Tags: bevacizumab, cytokine, eye, venous retinal branch occlusion, interleukin-8
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 2982-2988. doi:https://doi.org/10.1167/iovs.10-6299
Genomic Identification of Significant Targets in Ciliochoroidal Melanoma Free
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Tara A. McCannel; Barry L. Burgess; Stanley F. Nelson; Ascia Eskin; Bradley R. Straatsma
Tags: genome, melanoma, genes, cancer
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3018-3022. doi:https://doi.org/10.1167/iovs.10-5864
Contrast Sensitivity Outcomes in the ABC Trial: A Randomized Trial of Bevacizumab for Neovascular Age-Related Macular Degeneration Free
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Praveen J. Patel; Fred K. Chen; Lyndon Da Cruz; Gary S. Rubin; Adnan Tufail; for the ABC Trial Study Group
Tags: abc trial, bevacizumab, contrast sensitivity, exudative age-related macular degeneration, randomized controlled trial
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3089-3093. doi:https://doi.org/10.1167/iovs.10-6208
Cone Photoreceptor Abnormalities Correlate with Vision Loss in Patients with Stargardt Disease Free
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Yingming Chen; Kavitha Ratnam; Sanna M. Sundquist; Brandon Lujan; Radha Ayyagari; V. Harini Gudiseva; Austin Roorda; Jacque L. Duncan
Tags: retinal cone, stargardt's disease, blindness, atrophy
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3281-3292. doi:https://doi.org/10.1167/iovs.10-6538
Predictors of Short-Term Visual Outcome after Anti-VEGF Therapy of Macular Edema due to Central Retinal Vein Occlusion Free
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Ute E. K. Wolf-Schnurrbusch; Ramzi Ghanem; Simon P. Rothenbuehler; Volker Enzmann; Carsten Framme; Sebastian Wolf
Tags: anti-vascular endothelial growth factor therapy, central retinal vein occlusion, edema, embryonic lethal mutation, eye
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3334-3337. doi:https://doi.org/10.1167/iovs.10-6097
Reproducibility of Retinal Nerve Fiber Layer Thickness Measurements Using the Eye Tracker and the Retest Function of Spectralis SD-OCT in Glaucomatous and Healthy Control Eyes Free
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Stefan J. Langenegger; Jens Funk; Marc Töteberg-Harms
Tags: eye, glaucoma, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3338-3344. doi:https://doi.org/10.1167/iovs.10-6611
Early Multifocal Electroretinogram Findings during Intravitreal Ranibizumab Treatment for Neovascular Age-Related Macular Degeneration Free
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Claudio Campa; Richard Hagan; Jayashree N. Sahni; Malcolm C. Brown; Nicholas A. V. Beare; Heinrich Heimann; Simon P. Harding
Tags: electroretinography, exudative age-related macular degeneration, ranibizumab
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3446-3451. doi:https://doi.org/10.1167/iovs.10-6588
Comparison of In Vivo Confocal Microscopic Findings between epi-LASIK Procedures with Different Management of the Epithelial Flaps Free
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Wei-Li Chen; Elizabeth P. Shen; Yi-Ting Hsieh; Po-Ting Yeh; Tsung-Jen Wang; Fung-Rong Hu
Tags: cornea, epithelium, keratomileusis, laser in situ, microscopy, confocal, surgical flaps
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3640-3647. doi:https://doi.org/10.1167/iovs.10-6390
Overexpression of Matrix Metalloproteinase-1 (MMP-1) and MMP-3 in Superior Limbic Keratoconjunctivitis Free
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Yi-Chen Sun; Cheng-Hsiang Hsiao; Wei-Li Chen; Fung-Rong Hu
Tags: interstitial collagenase, stromelysin 1, superior limbic keratoconjunctivitis, tissue-inhibitor of metalloproteinase-1, conjunctiva
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3701-3705. doi:https://doi.org/10.1167/iovs.10-6324
Fundus Autofluorescence and Spectral-Domain Optical Coherence Tomography Characteristics in a Rapidly Progressing Form of Geographic Atrophy Free
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Monika Fleckenstein; Steffen Schmitz-Valckenberg; Christine Martens; Sebastian Kosanetzky; Christian K. Brinkmann; Gregory S. Hageman; Frank G. Holz
Tags: atrophy, fundus autofluorescence imaging, optical coherence tomography, eye, atrophic condition of skin
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3761-3766. doi:https://doi.org/10.1167/iovs.10-7021
Human Meibum Lipid Conformation and Thermodynamic Changes with Meibomian-Gland Dysfunction Free
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Douglas Borchman; Gary N. Foulks; Marta C. Yappert; James Bell; Emily Wells; Shantanu Neravetla; Victoria Greenstone
Tags: body temperature, lipids, temperature, meibomian gland, molecular conformation
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3805-3817. doi:https://doi.org/10.1167/iovs.10-6514

Review

AAV and Compacted DNA Nanoparticles for the Treatment of Retinal Disorders: Challenges and Future Prospects Free
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Zongchao Han; Shannon M. Conley; Muna I. Naash
Tags: dna, gene expression, gene therapy, nanoparticles, retinal diseases
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3051-3059. doi:https://doi.org/10.1167/iovs.10-6916

New Developments in Vision Research

Cold Thermoreceptors, Unexpected Players in Tear Production and Ocular Dryness Sensations Free
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Carlos Belmonte; Juana Gallar
Tags: cold sensation, common cold, sensory perception, thermoreceptors, cornea
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3888-3892. doi:https://doi.org/10.1167/iovs.09-5119

Letters to the Editor

Role of Higher Dietary Carbohydrate Intake in Cataract Development Free
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Ciro Costagliola; Lucio Lobefalo; Pier Enrico Gallenga
Tags: cataract, dietary carbohydrates
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3593. doi:https://doi.org/10.1167/iovs.11-7312
Author Response: Role of Higher Dietary Carbohydrate Intake in Cataract Development Free
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Chung-Jung Chiu; Allen Taylor
Tags: cataract, dietary carbohydrates
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3594. doi:https://doi.org/10.1167/iovs.11-7614
Surface and Volume Changes in the Lens during Accommodation Free
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Oscar A. Candia
Tags: lens (device), lens, crystalline, visual accommodation, volume
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3698. doi:https://doi.org/10.1167/iovs.11-7371
Three-Dimensional Magnetic Imaging of the Phakic Crystalline Lens During Accommodation Free
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Norman S. Levy
Tags: diagnostic imaging, lens, crystalline, visual accommodation
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3699-3700. doi:https://doi.org/10.1167/iovs.11-7385
Frequency-Doubling Technology and Parasol Cells Free
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Ted Maddess
Tags: technology
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3759. doi:https://doi.org/10.1167/iovs.11-7405
Author Response: Frequency-Doubling Technology and Parasol Cells Free
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William H. Swanson; Hao Sun; Barry B. Lee; Dingcai Cao
Tags: technology
Investigative Ophthalmology & Visual Science May 2011, Vol.52, 3759-3760. doi:https://doi.org/10.1167/iovs.11-7468
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