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Research Highlight

Does Emmetropization Need Rods? Free
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Frank Schaeffel
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6280. doi:https://doi.org/10.1167/iovs.14-15524
For a Better Understanding of Scleral Contact Lens–Related Pathophysiology Free
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Langis Michaud
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6430. doi:https://doi.org/10.1167/iovs.14-15564
A Functional Approach to Examine the Role of HTRA1 Versus ARMS2 in AMD Free
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Yingbin Fu
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6524. doi:https://doi.org/10.1167/iovs.14-15670
Enhancing Reliability of the Laser-Induced Choroidal Neovascularization Mouse Model: Insights From a New Study Free
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Jing Chen
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6535. doi:https://doi.org/10.1167/iovs.14-15615
What to do About Racial Disparities in Access to Glasses Among Children in the US? Free
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Nathan Congdon
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 7006. doi:https://doi.org/10.1167/iovs.14-15793

Anatomy and Pathology/Oncology

Elastin Development-Associated Extracellular Matrix Constituents of Subepithelial Connective Tissue in Human Pterygium Free
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Consuelo Pérez-Rico; Gemma Pascual; Sandra Sotomayor; Ángel Asúnsolo; Alberto Cifuentes; Natalio García-Honduvilla; Julia Buján
Tags: connective tissue, elastin, extracellular matrix, proteins, pterygium
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6309-6318. doi:https://doi.org/10.1167/iovs.14-14214
Axial Eye Growth and Refractive Error Development Can Be Modified by Exposing the Peripheral Retina to Relative Myopic or Hyperopic Defocus Free
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Alexandra Benavente-Pérez; Ann Nour; David Troilo
Tags: contact lenses, eye, lens (device), refractive errors, retina
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6765-6773. doi:https://doi.org/10.1167/iovs.14-14524

Biochemistry and Molecular Biology

Modeling of Human Uveal Melanoma in Zebrafish Xenograft Embryos Free
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Wietske van der Ent; Claudia Burrello; Amina F. A. S. Teunisse; Bruce R. Ksander; Pieter A. van der Velden; Martine J. Jager; Aart G. Jochemsen; B. Ewa Snaar-Jagalska
Tags: cell lines, dasatinib, embryo, transplantation, heterologous, uveal melanoma
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6612-6622. doi:https://doi.org/10.1167/iovs.14-15202

Clinical and Epidemiologic Research

Genetic Variants Associated With Severe Retinopathy of Prematurity in Extremely Low Birth Weight Infants Free
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M. Elizabeth Hartnett; Margaux A. Morrison; Silvia Smith; Tammy L. Yanovitch; Terri L. Young; Tarah Colaizy; Allison Momany; John Dagle; Waldemar A. Carlo; Erin A. S. Clark; Grier Page; Jeff Murray; Margaret M. DeAngelis; C. Michael Cotten
Tags: brain-derived neurotrophic factor, cohort studies, extremely low birth weight infant, genes, genetics
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6194-6203. doi:https://doi.org/10.1167/iovs.14-14841
Does Cigarette Smoking Alter the Risk of Pterygium? A Systematic Review and Meta-Analysis Free
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Shi Song Rong; Yi Peng; Yuan Bo Liang; Di Cao; Vishal Jhanji
Tags: meta-analysis, pterygium, smoking, systematic reviews
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6235-6243. doi:https://doi.org/10.1167/iovs.14-15046
A Longitudinal Study of Age-Related Changes in Intraocular Pressure: The Kangbuk Samsung Health Study Free
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Di Zhao; Myung Hun Kim; Roberto Pastor-Barriuso; Yoosoo Chang; Seungho Ryu; Yiyi Zhang; Sanjay Rampal; Hocheol Shin; Joon Mo Kim; David S. Friedman; Eliseo Guallar; Juhee Cho
Tags: health, intraocular pressure, longitudinal studies
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6244-6250. doi:https://doi.org/10.1167/iovs.14-14151
The Contributions of Near Work and Outdoor Activity to the Correlation Between Siblings in the Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) Study Free
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Lisa A. Jones-Jordan; Loraine T. Sinnott; Nicholas D. Graham; Susan A. Cotter; Robert N. Kleinstein; Ruth E. Manny; Donald O. Mutti; J. Daniel Twelker; Karla Zadnik; for the CLEERE Study Group
Tags: ethnic group, refractive errors, relationship - sibling, optometry, universities
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6333-6339. doi:https://doi.org/10.1167/iovs.14-14640
Prevalence of Age-Related Macular Degeneration in an Elderly Urban Chinese Population in China: The Jiangning Eye Study Free
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Hehua Ye; Qi Zhang; Xiaohong Liu; Xuan Cai; Wenjing Yu; Siyi Yu; Tianyu Wang; Wuyi Lu; Xiang Li; Haiying Jin; Yiqian Hu; Xiaoli Kang; Peiquan Zhao
Tags: age-related macular degeneration, china, chinese (other dialects), chinese people, eye
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6374-6380. doi:https://doi.org/10.1167/iovs.14-14899
Car Driving Performance in Hemianopia: An On-Road Driving Study Free
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Gera A. de Haan; Bart J. M. Melis-Dankers; Wiebo H. Brouwer; Ruud A. Bredewoud; Oliver Tucha; Joost Heutink
Tags: automobile driving, hemianopsia, visual fields, dutch, scotoma
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6482-6489. doi:https://doi.org/10.1167/iovs.14-14042
The Relationship Between Diabetic Retinopathy and Diabetic Nephropathy in a Population-Based Study in Korea (KNHANES V-2, 3) Free
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Won June Lee; Lucia Sobrin; Min Jeong Lee; Min Ho Kang; Mincheol Seong; Heeyoon Cho
Tags: diabetes mellitus, diabetic nephropathy, diabetic retinopathy, kidney diseases, korea
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6547-6553. doi:https://doi.org/10.1167/iovs.14-15001
Quantitative Analysis of Functional Changes Caused by Pinhole Glasses Free
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Won Soo Kim; In Ki Park; Yeoun Sook Chun
Tags: eyeglasses, visual acuity, pupil size
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6679-6685. doi:https://doi.org/10.1167/iovs.14-14801
Decreased Retinal Capillary Flow Is Not a Mediator of the Protective Myopia–Diabetic Retinopathy Relationship Free
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Ryan Eyn Kidd Man; Muhammad Bayu Sasongko; Jing Xie; William J. Best; Jonathan E. Noonan; Tiffany Ching Shen Lo; Jie Jin Wang; Chi D. Luu; Ecosse L. Lamoureux
Tags: blood capillaries, diabetes mellitus, diabetic retinopathy, eye, fluid flow
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6901-6907. doi:https://doi.org/10.1167/iovs.14-15137
Racial Disparities in Uncorrected and Undercorrected Refractive Error in the United States Free
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Mary Qiu; Sophia Y. Wang; Kuldev Singh; Shan C. Lin
Tags: racial disparities, refractive errors, ethnic group
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6996-7005. doi:https://doi.org/10.1167/iovs.13-12662

Cornea

Expression Analysis of the Transmembrane Mucin MUC20 in Human Corneal and Conjunctival Epithelia Free
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Ashley M. Woodward; Pablo Argüeso
Tags: conjunctiva, cornea, mucins
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6132-6138. doi:https://doi.org/10.1167/iovs.14-15269
Functional Impact of ZEB1 Mutations Associated With Posterior Polymorphous and Fuchs' Endothelial Corneal Dystrophies Free
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Duk-Won D. Chung; Ricardo F. Frausto; Lydia B. Ann; Michelle S. Jang; Anthony J. Aldave
Tags: endothelium, hereditary corneal dystrophy, missense mutation, mutation, proteins
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6159-6166. doi:https://doi.org/10.1167/iovs.14-15247
SLURP-1 Modulates Corneal Homeostasis by Serving as a Soluble Scavenger of Urokinase-Type Plasminogen Activator Free
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Sudha Swamynathan; Shivalingappa K. Swamynathan
Tags: cornea, urokinase, urokinase plasminogen activator receptor, homeostasis, binding (molecular function)
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6251-6261. doi:https://doi.org/10.1167/iovs.14-15107
Ocular Surface Injury Induces Inflammation in the Brain: In Vivo and Ex Vivo Evidence of a Corneal–Trigeminal Axis Free
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Giulio Ferrari; Fabio Bignami; Chiara Giacomini; Eleonora Capitolo; Giancarlo Comi; Linda Chaabane; Paolo Rama
Tags: alkalies, burns, cornea, inflammation, trigeminal ganglion
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6289-6300. doi:https://doi.org/10.1167/iovs.14-13984
Oxygen Diffusion and Edema With Modern Scleral Rigid Gas Permeable Contact Lenses Free
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Vicente Compañ; Cristina Oliveira; Marcel Aguilella-Arzo; Sergio Mollá; Sofia C. Peixoto-de-Matos; José M. González-Méijome
Tags: cornea, edema, lens (device), lens, crystalline, oxygen
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6421-6429. doi:https://doi.org/10.1167/iovs.14-14038
The Effect of Preservatives and Antiglaucoma Treatments on the Ocular Surface of Mice With Dry Eye Free
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Stefano Barabino; Sophie Antonelli; Nicolas Cimbolini; Virginie Mauro; Marielle Bouzin
Tags: conjunctiva, cornea, dry eye syndromes, mice, travoprost
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6499-6504. doi:https://doi.org/10.1167/iovs.14-14548
Vitronectin: A Migration and Wound Healing Factor for Human Corneal Epithelial Cells Free
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Sharron Chow; Nick Di Girolamo
Tags: cornea, corneal epithelial cells, vitronectin, wound closure, wound healing
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6590-6600. doi:https://doi.org/10.1167/iovs.14-15054
Ocular Forward Light Scattering and Corneal Backward Light Scattering in Patients With Dry Eye Free
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Shizuka Koh; Naoyuki Maeda; Chikako Ikeda; Sanae Asonuma; Hayato Mitamura; Yoshinori Oie; Takeshi Soma; Motokazu Tsujikawa; Satoshi Kawasaki; Kohji Nishida
Tags: cornea, dry eye syndromes, eye
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6601-6606. doi:https://doi.org/10.1167/iovs.14-15125
Mesenchymal Stem Cells Home to Inflamed Ocular Surface and Suppress Allosensitization in Corneal Transplantation Free
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Masahiro Omoto; Kishore R. Katikireddy; Alexandra Rezazadeh; Thomas H. Dohlman; Sunil K. Chauhan
Tags: alloimmunity, cornea, keratoplasty, mesenchymal stem cells, mice
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6631-6638. doi:https://doi.org/10.1167/iovs.14-15413
Keratocytes Create Stromal Spaces to Promote Corneal Neovascularization Via MMP13 Expression Free
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Jing Ma; Dan Zhou; Meihua Fan; He Wang; Caihong Huang; Zhaoqiang Zhang; Yang Wu; Wei Li; Yongxiong Chen; Zuguo Liu
Tags: alkalies, burns, cornea, corneal neovascularization, keratocytes
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6691-6703. doi:https://doi.org/10.1167/iovs.14-14746
Comparison of Aqueous Levels of Inflammatory Mediators Between Toxic Anterior Segment Syndrome and Endotoxin-Induced Uveitis Animal Models Free
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Youngsub Eom; Dong Yeol Lee; Bo-Ram Kang; Jeong-Hwa Heo; Kyung-Ho Shin; Hyo Myung Kim; Jong Suk Song
Tags: animal model, endotoxins, inflammation mediators, toxic anterior segment syndrome, uveitis
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6704-6710. doi:https://doi.org/10.1167/iovs.14-15051
Upregulation of Bone Morphogenetic Protein-1/Mammalian Tolloid and Procollagen C-Proteinase Enhancer-1 in Corneal Scarring Free
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Francois Malecaze; Dawiyat Massoudi; Pierre Fournié; Cyrielle Tricoire; Myriam Cassagne; Marilyne Malbouyres; David J. S. Hulmes; Catherine Moali; Stephane D. Galiacy
Tags: cicatrix, cornea, endopeptidases, enhancer of transcription, mammals
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6712-6721. doi:https://doi.org/10.1167/iovs.13-13800
Vitelline Membrane Outer Layer 1 Homolog Interacts With Lysozyme C and Promotes the Stabilization of Tear Film Free
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Zhe Wang; Ziyan Chen; Qian Yang; Yibo Jiang; Liping Lin; Xialin Liu; Kaili Wu
Tags: muramidase, stabilization, tear film finding, vitelline membrane, proteins
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6722-6727. doi:https://doi.org/10.1167/iovs.14-14491
NK1 Receptor Antagonists as a New Treatment for Corneal Neovascularization Free
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Fabio Bignami; Chiara Giacomini; Anna Lorusso; Andrea Aramini; Paolo Rama; Giulio Ferrari
Tags: alkalies, antagonists, burns, cornea, corneal neovascularization
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6783-6794. doi:https://doi.org/10.1167/iovs.14-14553
Dry Eye-Induced CCR7+CD11b+ Cell Lymph Node Homing Is Induced by COX-2 Activities Free
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Yong Woo Ji; Yuri Seo; Wungrak Choi; Areum Yeo; Hyemi Noh; Eung Kweon Kim; Hyung Keun Lee
Tags: cyclooxygenase-2, cyclooxygenase-2 inhibitors, macrophage-1 antigen, cornea, interleukin-17
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6829-6838. doi:https://doi.org/10.1167/iovs.14-14744
R-spondin1 Regulates Cell Proliferation of Corneal Endothelial Cells via the Wnt3a/β-Catenin Pathway Free
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Naoki Okumura; Takahiro Nakamura; EunDuck P. Kay; Makiko Nakahara; Shigeru Kinoshita; Noriko Koizumi
Tags: cell proliferation, chronic exertional compartment syndrome, cornea, rspo1 gene, endothelial cells
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6861-6869. doi:https://doi.org/10.1167/iovs.14-14091
Biocompatibility and Functionality of a Tissue-Engineered Living Corneal Stroma Transplanted in the Feline Eye Free
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Marie Boulze Pankert; Benjamin Goyer; Fatma Zaguia; Myriam Bareille; Marie-Claude Perron; Xinling Liu; J. Douglas Cameron; Stéphanie Proulx; Isabelle Brunette
Tags: body tissue, cats, cornea, corneal stroma, eye
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6908-6920. doi:https://doi.org/10.1167/iovs.14-14720
The Acetylcholine Signaling Network of Corneal Epithelium and Its Role in Regulation of Random and Directional Migration of Corneal Epithelial Cells Free
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Alex I. Chernyavsky; Valentin Galitovskiy; Igor B. Shchepotin; James V. Jester; Sergei A. Grando
Tags: acetylcholine, cholinergic agents, chronic exertional compartment syndrome, cornea, regulation
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6921-6933. doi:https://doi.org/10.1167/iovs.14-14667
Human Limbal Mesenchymal Cells Support the Growth of Human Corneal Epithelial Stem/Progenitor Cells Free
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Martin N. Nakatsu; Sheyla González; Hua Mei; Sophie X. Deng
Tags: cornea, epithelium, mesenchymal stem cells, stem cells, chief complaint
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6953-6959. doi:https://doi.org/10.1167/iovs.14-14999
Exposure of a Corneal Epithelial Cell Line (hTCEpi) to Demodex-Associated Bacillus Proteins Results in an Inflammatory Response Free
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Frederick W. McMahon; Clair Gallagher; Niamh O'Reilly; Martin Clynes; Finbarr O'Sullivan; Kevin Kavanagh
Tags: bacillus, proteins, cornea, corneal epithelial cells
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 7019-7028. doi:https://doi.org/10.1167/iovs.14-15018

Genetics

Direct-to-Consumer Personal Genome Testing for Age-Related Macular Degeneration Free
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Gabriëlle H. S. Buitendijk; Najaf Amin; Albert Hofman; Cornelia M. van Duijn; Johannes R. Vingerling; Caroline C. W. Klaver
Tags: age-related macular degeneration, dna, genetic screening, genome, genotype determination
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6167-6174. doi:https://doi.org/10.1167/iovs.14-15142
Dependable and Efficient Clinical Utility of Target Capture-Based Deep Sequencing in Molecular Diagnosis of Retinitis Pigmentosa Free
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Jing Wang; Victor W. Zhang; Yanming Feng; Xia Tian; Fang-Yuan Li; Cavatina Truong; Guoli Wang; Pei-Wen Chiang; Richard A. Lewis; Lee-Jun C. Wong
Tags: genes, massively-parallel genome sequencing, molecular diagnostic techniques, mutation, retinitis pigmentosa
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6213-6223. doi:https://doi.org/10.1167/iovs.14-14936
Genetic Determinants of Age-Related Macular Degeneration in Diverse Populations From the PAGE Study Free
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Nicole A. Restrepo; Kylee L. Spencer; Robert Goodloe; Tiana A. Garrett; Gerardo Heiss; Petra Bůžková; Neal Jorgensen; Richard A. Jensen; Tara C. Matise; Lucia A. Hindorff; Barbara E. K. Klein; Ronald Klein; Tien Y. Wong; Ching-Yu Cheng; Belinda K. Cornes; E.-Shyong Tai; Marylyn D. Ritchie; Jonathan L. Haines; Dana C. Crawford
Tags: age-related macular degeneration, genetics, lipids, meta-analysis, perfluorocarbon-associated gas exchange
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6839-6850. doi:https://doi.org/10.1167/iovs.14-14246
The Phenotypic Variability of Retinal Dystrophies Associated With Mutations in CRX, With Report of a Novel Macular Dystrophy Phenotype Free
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Sarah Hull; Gavin Arno; Vincent Plagnol; Sarah Chamney; Isabelle Russell-Eggitt; Dorothy Thompson; Simon C. Ramsden; Graeme C. M. Black; Anthony Robson; Graham E. Holder; Anthony T. Moore; Andrew R. Webster
Tags: macular dystrophy, mutation, phenotype, retinal dystrophies, family
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6934-6944. doi:https://doi.org/10.1167/iovs.14-14715
Mutation Screening of Mitochondrial DNA as Well as OPA1 and OPA3 in a Chinese Cohort With Suspected Hereditary Optic Atrophy Free
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Jieqiong Chen; Ke Xu; Xiaohui Zhang; Feng Jiang; Lijuan Liu; Bing Dong; Yanfan Ren; Yang Li
Tags: cohort studies, dead on arrival, dna, mitochondrial, mutation, optic atrophy, autosomal dominant
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6987-6995. doi:https://doi.org/10.1167/iovs.14-14953

Glaucoma

A Theoretical Model to Allow Prediction of the CSF Pressure From Observations of the Retinal Venous Pulse Free
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Peter S. Stewart; Oliver E. Jensen; Alexander J. E. Foss
Tags: cerebrospinal fluid pressure, intraocular pressure, models, theoretical, venous pulse, eye
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6319-6323. doi:https://doi.org/10.1167/iovs.14-14331
Age-Related Differences in Longitudinal Structural Change by Spectral-Domain Optical Coherence Tomography in Early Experimental Glaucoma Free
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Hongli Yang; Lin He; Stuart K. Gardiner; Juan Reynaud; Galen Williams; Christy Hardin; Nicholas G. Strouthidis; J. Crawford Downs; Brad Fortune; Claude F. Burgoyne
Tags: eye, glaucoma, intraocular pressure, optic disk, optical coherence tomography
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6409-6420. doi:https://doi.org/10.1167/iovs.14-14156
Nerve Fiber Layer Thinning Lags Retinal Ganglion Cell Density Following Crush Axonopathy Free
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Gustavo C. Munguba; Sanja Galeb; Yuan Liu; David C. Landy; Daisy Lam; Andrew Camp; Sinthia Samad; Mary L. Tapia; Richard K. Lee
Tags: axonal neuropathy, diagnostic imaging, mice, nerve fibers, retina
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6505-6513. doi:https://doi.org/10.1167/iovs.14-14525
Changes in Scleral Collagen Organization in Murine Chronic Experimental Glaucoma Free
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Jacek K. Pijanka; Elizabeth C. Kimball; Mary E. Pease; Ahmed Abass; Thomas Sorensen; Thao D. Nguyen; Harry A. Quigley; Craig Boote
Tags: collagen, diagnostic radiologic examination, glaucoma, mice, roentgen rays
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6554-6564. doi:https://doi.org/10.1167/iovs.14-15047
Evaluation of Acquired Color Vision Deficiency in Glaucoma Using the Rabin Cone Contrast Test Free
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Yuichi Niwa; Sanae Muraki; Fumiyuki Naito; Takayuki Minamikawa; Masahito Ohji
Tags: color vision defect, glaucoma, retinal cone, glaucoma screening
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6686-6690. doi:https://doi.org/10.1167/iovs.14-14079
Outcomes of Laser Peripheral Iridotomy in Angle Closure Subgroups According to Anterior Segment Optical Coherence Tomography Parameters Free
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Seungbong Han; Kyung Rim Sung; Kyoung Sub Lee; Ji Wook Hong
Tags: eye, laser iridotomy, optical coherence tomography
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6795-6801. doi:https://doi.org/10.1167/iovs.14-14714
The Relationship Between Retinal Nerve Fiber Layer Thickness and Optic Nerve Head Neuroretinal Rim Tissue in Glaucoma Free
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Nimesh B. Patel; Michael Sullivan-Mee; Ronald S. Harwerth
Tags: glaucoma, optic disk, retinal nerve fiber layer, primates, eye
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6802-6816. doi:https://doi.org/10.1167/iovs.14-14191
Astrocyte Processes Label for Filamentous Actin and Reorient Early Within the Optic Nerve Head in a Rat Glaucoma Model Free
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Shandiz Tehrani; Elaine C. Johnson; William O. Cepurna; John C. Morrison
Tags: actins, astrocytes, glaucoma, optic disk, raised intraocular pressure
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6945-6952. doi:https://doi.org/10.1167/iovs.14-14969

Immunology and Microbiology

Caveolin-1 Increases Proinflammatory Chemoattractants and Blood–Retinal Barrier Breakdown but Decreases Leukocyte Recruitment in Inflammation Free
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Xiaoman Li; Xiaowu Gu; Timothy M. Boyce; Min Zheng; Alaina M. Reagan; Hui Qi; Nawajes Mandal; Alex W. Cohen; Michelle C. Callegan; Daniel J. J. Carr; Michael H. Elliott
Tags: blood-retinal barrier, caveolins, chemotactic factors, inflammation, leukocytes
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6224-6234. doi:https://doi.org/10.1167/iovs.14-14613
Interleukin 17 Regulates Mer Tyrosine Kinase–Positive Cells in Pseudomonas aeruginosa Keratitis Free
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Cui Li; Sharon A. McClellan; Ronald Barrett; Linda D. Hazlett
Tags: infections, interleukin-17, mice, mice, inbred c57bl, cornea
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6886-6900. doi:https://doi.org/10.1167/iovs.14-14522

Lens

Molecular Mechanism of Formation of Cortical Opacity in CRYAAN101D Transgenic Mice Free
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Shylaja M. Hegde; Kiran Srivastava; Ekta Tiwary; Om P. Srivastava
Tags: lens (device), lens, crystalline, mice, transgenic
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6398-6408. doi:https://doi.org/10.1167/iovs.14-14623
Connexin46fs380 Causes Progressive Cataracts Free
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Viviana M. Berthoud; Peter J. Minogue; Helena Yu; Joseph I. Snabb; Eric C. Beyer
Tags: cataract, heterozygote, homozygote, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6639-6648. doi:https://doi.org/10.1167/iovs.14-15012

Low Vision

Developing the Impact of Vision Impairment–Very Low Vision (IVI-VLV) Questionnaire as Part of the LoVADA Protocol Free
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Robert P. Finger; Betty Tellis; Julie Crewe; Jill E. Keeffe; Lauren N. Ayton; Robyn H. Guymer
Tags: questionnaires, visual impairment, blindness
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6150-6158. doi:https://doi.org/10.1167/iovs.14-14731

Multidisciplinary Ophthalmic Imaging

In Vivo Imaging of a New Indocyanine Green Micelle Formulation in an Animal Model of Laser-Induced Choroidal Neovascularization Free
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Johanna Meyer; Alexander Cunea; Dagmar Sonntag-Bensch; Pia Welker; Kai Licha; Frank G. Holz; Steffen Schmitz-Valckenberg
Tags: animal model, choroidal neovascularization, diagnostic imaging, dyes, fluorescence
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6204-6212. doi:https://doi.org/10.1167/iovs.13-13617
In Vivo Three-Dimensional Characterization of the Healthy Human Lamina Cribrosa With Adaptive Optics Spectral-Domain Optical Coherence Tomography Free
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Zach Nadler; Bo Wang; Joel S. Schuman; R. Daniel Ferguson; Ankit Patel; Daniel X. Hammer; Richard A. Bilonick; Hiroshi Ishikawa; Larry Kagemann; Ian A. Sigal; Gadi Wollstein
Tags: cribriform plate, optical coherence tomography, optics, eye, diameter
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6459-6466. doi:https://doi.org/10.1167/iovs.14-15177
Repeatability of Peripapillary Retinal Nerve Fiber Layer and Inner Retinal Thickness Among Two Spectral Domain Optical Coherence Tomography Devices Free
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Juliane Matlach; Martin Wagner; Uwe Malzahn; Winfried Göbel
Tags: optical coherence tomography, retinal nerve fiber layer, glaucoma
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6536-6546. doi:https://doi.org/10.1167/iovs.14-15072
Use of Anterior Segment Optical Coherence Tomography to Predict Corneal Graft Rejection in Small Animal Models Free
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Yu-Chi Liu; Nyein Chan Lwin; Nicole Shu Wen Chan; Jodhbir S. Mehta
Tags: animal model, inflammation, keratoplasty, optical coherence tomography, rejection (psychology)
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6736-6741. doi:https://doi.org/10.1167/iovs.14-14475
The Association Between the Foveal Avascular Zone and Retinal Thickness Free
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Toco Y. P. Chui; Dean A. VanNasdale; Ann E. Elsner; Stephen A. Burns
Tags: blood capillaries, diagnostic imaging, diameter, eye, meridians
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6870-6877. doi:https://doi.org/10.1167/iovs.14-15446

Nantotechnology and Regenerative Medicine

Retinal Regeneration Following OCT-Guided Laser Injury in Zebrafish Free
PDF
Rose M. DiCicco; Brent A. Bell; Charles Kaul; Joe G. Hollyfield; Bela Anand-Apte; Brian D. Perkins; Yuankai K. Tao; Alex Yuan
Tags: laser injuries, lasers, light coagulation, zebrafish, diagnostic imaging
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6281-6288. doi:https://doi.org/10.1167/iovs.14-14724

Physiology and Pharmacology

DA-6034–Induced Mucin Secretion Via Ca2+-Dependent Pathways Through P2Y Receptor Stimulation Free
PDF
Hun Lee; Eung Kweon Kim; Ji Yeon Kim; Yu-Mi Yang; Dong Min Shin; Kyung Koo Kang; Tae-im Kim
Tags: bodily secretions, conjunctival epithelial cells, mucins, proteins
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6565-6574. doi:https://doi.org/10.1167/iovs.14-13875

Retina

The External Limiting Membrane in Early-Onset Stargardt Disease Free
PDF
Winston Lee; Kalev Nõupuu; Maris Oll; Tobias Duncker; Tomas Burke; Jana Zernant; Srilaxmi Bearelly; Stephen H. Tsang; Janet R. Sparrow; Rando Allikmets
Tags: embryonic lethal mutation, stargardt's disease, tissue membrane
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6139-6149. doi:https://doi.org/10.1167/iovs.14-15126
Bioactive Lysophospholipids Generated by Hepatic Lipase Degradation of Lipoproteins Lead to Complement Activation via the Classical Pathway Free
PDF
Wanchao Ma; David C. Paik; Gaetano R. Barile
Tags: catabolism, complement activation, hepatic lipase, lipoproteins, low-density lipoproteins
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6187-6193. doi:https://doi.org/10.1167/iovs.14-14352
Visually-Driven Ocular Growth in Mice Requires Functional Rod Photoreceptors Free
PDF
Han na Park; Seema B. Jabbar; Christopher C. Tan; Curran S. Sidhu; Jane Abey; Fazila Aseem; Gregor Schmid; P. Michael Iuvone; Machelle T. Pardue
Tags: dopamine, mice, rod photoreceptors, eye, myopia
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6272-6279. doi:https://doi.org/10.1167/iovs.14-14648
CNGB3-Achromatopsia Clinical Trial With CNTF: Diminished Rod Pathway Responses With No Evidence of Improvement in Cone Function Free
PDF
Wadih M. Zein; Brett G. Jeffrey; Henry E. Wiley; Amy E. Turriff; Santa J. Tumminia; Weng Tao; Ronald A. Bush; Dario Marangoni; Rong Wen; Lisa L. Wei; Paul A. Sieving
Tags: achromatopsia, ciliary neurotrophic factor, retinal cone, rod photoreceptors, implants
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6301-6308. doi:https://doi.org/10.1167/iovs.14-14860
Prognostic Value of Multifocal Electroretinography and Optical Coherence Tomography in Eyes Undergoing Panretinal Photocoagulation for Diabetic Retinopathy Free
PDF
Ying Zhu; Ting Zhang; Ke-yan Wang; Ge-zhi Xu
Tags: diabetic retinopathy, electroretinography, eye, optical coherence tomography, panretinal photocoagulation
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6358-6364. doi:https://doi.org/10.1167/iovs.14-14704
IκB Kinase-β Inhibitor IMD-0354 Beneficially Suppresses Retinal Vascular Permeability in Streptozotocin-Induced Diabetic Mice Free
PDF
Anton Lennikov; Miki Hiraoka; Akira Abe; Shigeaki Ohno; Tomoyuki Fujikawa; Akiko Itai; Hiroshi Ohguro
Tags: diabetes mellitus, mice, phosphotransferases, streptozocin, vascular permeability
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6365-6373. doi:https://doi.org/10.1167/iovs.14-14671
Comparison Between Multifocal Electroretinography and Microperimetry in Age-Related Macular Degeneration Free
PDF
Zhichao Wu; Lauren N. Ayton; Robyn H. Guymer; Chi D. Luu
Tags: age-related macular degeneration, electroretinography, visual acuity
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6431-6439. doi:https://doi.org/10.1167/iovs.14-14407
Macular Choroidal Thicknesses in Healthy Adults—Relationship With Ocular and Demographic Factors Free
PDF
Colin S. H. Tan; Kai Xiong Cheong
Tags: adult, demography, eye, linear regression, macula densa
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6452-6458. doi:https://doi.org/10.1167/iovs.13-13771
Overexpression of HtrA1 and Exposure to Mainstream Cigarette Smoke Leads to Choroidal Neovascularization and Subretinal Deposits in Aged Mice Free
PDF
Mao Nakayama; Daisuke Iejima; Masakazu Akahori; Junzo Kamei; Asako Goto; Takeshi Iwata
Tags: choroidal neovascularization, cigarette smoke, htra1 gene, mice, protein overexpression
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6514-6523. doi:https://doi.org/10.1167/iovs.14-14453
Reliability of the Mouse Model of Choroidal Neovascularization Induced by Laser Photocoagulation Free
PDF
Stephen H. Poor; Yubin Qiu; Elizabeth S. Fassbender; Siyuan Shen; Amber Woolfenden; Andrea Delpero; Yong Kim; Natasha Buchanan; Thomas C. Gebuhr; Shawn M. Hanks; Erik L. Meredith; Bruce D. Jaffee; Thaddeus P. Dryja
Tags: choroidal neovascularization, lasers, light coagulation, mice, reliability
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6525-6534. doi:https://doi.org/10.1167/iovs.14-15067
Retinal Layer Measurements After Successful Macula-Off Retinal Detachment Repair Using Optical Coherence Tomography Free
PDF
Marcel N. Menke; Jens H. Kowal; Pascal Dufour; Ute E. Wolf-Schnurrbusch; Lala Ceklic; Carsten Framme; Sebastian Wolf
Tags: detached retina repairs, macula densa, macula lutea, optical coherence tomography, surgical procedures, operative
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6575-6579. doi:https://doi.org/10.1167/iovs.14-14412
Longitudinal Changes in Retinal Nerve Fiber Layer Thickness After Vitrectomy for Epiretinal Membrane Free
PDF
Sung-Bok Lee; Yong-Il Shin; Young-Joon Jo; Jung-Yeul Kim
Tags: epiretinal membrane, eye, retinal nerve fiber layer, vitrectomy
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6607-6611. doi:https://doi.org/10.1167/iovs.14-14196
A Quantitative Approach to Identify Morphological Features Relevant for Visual Function in Ranibizumab Therapy of Neovascular AMD Free
PDF
Philipp Roberts; Tamara Jasmin Mittermueller; Alessio Montuoro; Florian Sulzbacher; Marion Munk; Stefan Sacu; Ursula Schmidt-Erfurth
Tags: embryonic lethal mutation, exudative age-related macular degeneration, ranibizumab, vision, visual acuity
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6623-6630. doi:https://doi.org/10.1167/iovs.14-14293
Quantification of the Changes in the Openness of the Major Temporal Arcade in Retinal Fundus Images of Preterm Infants With Plus Disease Free
PDF
Faraz Oloumi; Rangaraj M. Rangayyan; Anna L. Ells
Tags: infant, infant, premature, significance, retina
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6728-6735. doi:https://doi.org/10.1167/iovs.13-13640
Inner Retinal Optic Neuropathy: Vitreomacular Surgery–Associated Disruption of the Inner Retina Free
PDF
Billy X. Pan; Kenneth M. Yee; Fred N. Ross-Cisneros; Alfredo A. Sadun; Jerry Sebag
Tags: optic nerve disorders, retina, surgical procedures, operative, repeat surgery
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6756-6764. doi:https://doi.org/10.1167/iovs.14-15235
Flicker Light–Induced Retinal Vasodilation Is Unaffected by Inhibition of Epoxyeicosatrienoic Acids and Prostaglandins in Humans Free
PDF
Jonathan E. Noonan; Gregory J. Dusting; Thanh T. Nguyen; Alicia J. Jenkins; Ryan E. K. Man; William J. Best; Daniel A. Dias; Nirupama S. Jayasinghe; Ute Roessner; Ecosse L. Lamoureux
Tags: fluconazole, phosphatidylglycerols, photopsia, prostaglandins, vasodilation
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 7007-7013. doi:https://doi.org/10.1167/iovs.14-14947

Retinal Cell Biology

Interphotoreceptor Retinoid-Binding Protein (IRBP) Promotes Retinol Uptake and Release by Rat Müller Cells (rMC-1) In Vitro: Implications for the Cone Visual Cycle Free
PDF
Brandi S. Betts-Obregon; Federico Gonzalez-Fernandez; Andrew T. Tsin
Tags: culture media, conditioned, proteins, retinal cone, retinoids, vitamin a
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6265-6271. doi:https://doi.org/10.1167/iovs.14-14721
Caspase-9 Mediates Photoreceptor Death After Blunt Ocular Trauma Free
PDF
Richard J. Blanch; Zubair Ahmed; Adam R. Thompson; Nsikan Akpan; David R. J. Snead; Martin Berry; Carol M. Troy; Robert A. H. Scott; Ann Logan
Tags: caspase-9, ocular trauma, photoreceptors, wounds and injuries, caspases
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6350-6357. doi:https://doi.org/10.1167/iovs.13-13708
Endoglin Promotes Angiogenesis in Cell- and Animal-Based Models of Retinal Neovascularization Free
PDF
Joshua M. Barnett; Sandra Suarez; Gary W. McCollum; John S. Penn
Tags: angiogenesis, hypoxia, retinal neovascularization, rats, anti-vascular endothelial growth factor therapy
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6490-6498. doi:https://doi.org/10.1167/iovs.14-14945
γδ T Cells as a Major Source of IL-17 Production During Age-Dependent RPE Degeneration Free
PDF
Zhenyang Zhao; Pei Xu; Zuliang Jie; Yiqin Zuo; Bo Yu; Lynn Soong; Jiaren Sun; Yan Chen; Jiyang Cai
Tags: diet, heart failure, interleukin-17, mice, tissue degeneration
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6580-6589. doi:https://doi.org/10.1167/iovs.14-15166
Interleukin-18 Induces Retinal Pigment Epithelium Degeneration in Mice Free
PDF
Ryo Ijima; Hiroki Kaneko; Fuxiang Ye; Yosuke Nagasaka; Kei Takayama; Keiko Kataoka; Shu Kachi; Takeshi Iwase; Hiroko Terasaki
Tags: interleukin-18, mice, tissue degeneration, retinal pigment epithelium
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6673-6678. doi:https://doi.org/10.1167/iovs.14-15367
PEDF Improves Mitochondrial Function in RPE Cells During Oxidative Stress Free
PDF
Yuan He; Kar Wah Leung; Yuan Ren; Jinzhi Pei; Jian Ge; Joyce Tombran-Tink
Tags: mitochondria, oxidative stress, retinal pigment cell
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6742-6755. doi:https://doi.org/10.1167/iovs.14-14696
Characterization of Oxygen-Induced Retinopathy in Mice Carrying an Inactivating Point Mutation in the Catalytic Site of ADAM15 Free
PDF
Thorsten Maretzky; Carl P. Blobel; Victor Guaiquil
Tags: catalytic domain, mice, oxygen, point mutation, retinal diseases
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6774-6782. doi:https://doi.org/10.1167/iovs.14-14472
Role of Metallothioneins 1 and 2 in Ocular Neovascularization Free
PDF
Shinsuke Nakamura; Masamitsu Shimazawa; Yuki Inoue; Shinsuke Takata; Yasushi Ito; Kazuhiro Tsuruma; Tsunehiko Ikeda; Akiko Honda; Masahiko Satoh; Hideaki Hara
Tags: metallothionein, mice, neovascularization, pathologic, vascular endothelial growth factor a, vitreous body
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6851-6860. doi:https://doi.org/10.1167/iovs.14-14545
Retinal Mitochondrial DNA Mismatch Repair in the Development of Diabetic Retinopathy, and Its Continued Progression After Termination of Hyperglycemia Free
PDF
Manish Mishra; Renu A. Kowluru
Tags: diabetic retinopathy, dna, mitochondrial, hyperglycemia, mismatch, mismatch repair
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6960-6967. doi:https://doi.org/10.1167/iovs.14-15020
Interleukin-17 Induces Angiogenesis in Human Choroidal Endothelial Cells In Vitro Free
PDF
Ying Chen; Murui Zhong; Liang Liang; Fengjuan Gu; Hui Peng
Tags: chronic exertional compartment syndrome, endothelial cells, interleukin-17, rhoa gtp-binding protein, angiogenesis
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6968-6975. doi:https://doi.org/10.1167/iovs.14-15029

Translational

The Demethylating Agent 5-Aza Reduces the Growth, Invasiveness, and Clonogenicity of Uveal and Cutaneous Melanoma Free
PDF
Fatemeh Rajaii; Laura Asnaghi; Raymond Enke; Shannath L. Merbs; James T. Handa; Charles G. Eberhart
Tags: azacitidine, malignant melanoma, cutaneous, melanoma, demethylating agents, uvea
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6178-6186. doi:https://doi.org/10.1167/iovs.14-13933

Visual Neuroscience

Evaluation of Visual Structural and Functional Factors That Predict the Development of Multiple Sclerosis in Clinically Isolated Syndrome Patients Free
PDF
Consuelo Pérez-Rico; Lucia Ayuso-Peralta; Lluisa Rubio-Pérez; Isabel Roldán-Díaz; Juan Arévalo-Serrano; Dolores Jiménez-Jurado; Román Blanco
Tags: clinically isolated syndrome, eye, multiple sclerosis
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6127-6131. doi:https://doi.org/10.1167/iovs.14-14807
The Effect of Spectral Property and Intensity of Light on Natural Refractive Development and Compensation to Negative Lenses in Guinea Pigs Free
PDF
Wentao Li; Weizhong Lan; Shiqi Yang; Yunru Liao; Qinglin Xu; Lixia Lin; Zhikuan Yang
Tags: caviidae, lens (device), lens, crystalline, light intensity, refraction
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6324-6332. doi:https://doi.org/10.1167/iovs.13-13802
Visuocortical Function in Infants With a History of Neonatal Jaundice Free
PDF
Chuan Hou; Anthony M. Norcia; Ashima Madan; William V. Good
Tags: bilirubin, infant, jaundice, medical history, neonatal jaundice
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6443-6449. doi:https://doi.org/10.1167/iovs.14-14261
Photophobia and Abnormally Sustained Pupil Responses in a Mouse Model of Bradyopsia Free
PDF
Adisa Kuburas; Stewart Thompson; Nikolai O. Artemyev; Randy H. Kardon; Andrew F. Russo
Tags: mice, photophobia, pupil, mice, knockout
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6878-6885. doi:https://doi.org/10.1167/iovs.14-14784
White Matter Consequences of Retinal Receptor and Ganglion Cell Damage Free
PDF
Shumpei Ogawa; Hiromasa Takemura; Hiroshi Horiguchi; Masahiko Terao; Tomoki Haji; Franco Pestilli; Jason D. Yeatman; Hiroshi Tsuneoka; Brian A. Wandell; Yoichiro Masuda
Tags: cell injury, diffusion, ganglia, optic atrophy, hereditary, leber, optic radiation
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6976-6986. doi:https://doi.org/10.1167/iovs.14-14737

Visual Psychophysics and Physiological Optics

Dark-Adaptation Functions in Molecularly Confirmed Achromatopsia and the Implications for Assessment in Retinal Therapy Trials Free
PDF
Jonathan Aboshiha; Vy Luong; Jill Cowing; Adam M. Dubis; James W. Bainbridge; Robin R. Ali; Andrew R. Webster; Anthony T. Moore; Frederick W. Fitzke; Michel Michaelides
Tags: achromatopsia, dark adaptation
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6340-6349. doi:https://doi.org/10.1167/iovs.14-14910
High-Resolution Adaptive Optics Retinal Imaging of Cellular Structure in Choroideremia Free
PDF
Jessica I. W. Morgan; Grace Han; Eva Klinman; William M. Maguire; Daniel C. Chung; Albert M. Maguire; Jean Bennett
Tags: choroideremia, diagnostic imaging, retina, retinal cone, mosaicism
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6381-6397. doi:https://doi.org/10.1167/iovs.13-13454
Nature of the Visual Loss in Observers With Leber's Congenital Amaurosis Caused by Specific Mutations in RPE65 Free
PDF
Caterina Ripamonti; G. Bruce Henning; Robin R. Ali; James W. Bainbridge; Scott J. Robbie; Venki Sundaram; Vy A. Luong; L. Ingeborgh van den Born; Ingele Casteels; Thomy J. L. de Ravel; Anthony T. Moore; Andrew Stockman
Tags: blindness, contrast sensitivity, eye, flicker fusion, leber's amaurosis
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6817-6828. doi:https://doi.org/10.1167/iovs.14-14923
Amplitude of Accommodation in Type 1 Diabetes Free
PDF
Adnan; Nathan Efron; Ankit Mathur; Katie Edwards; Nicola Pritchard; Marwan Suheimat; David A. Atchison
Tags: diabetes mellitus, diabetes mellitus, type 1, diabetes mellitus, type 2, visual accommodation
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 7014-7018. doi:https://doi.org/10.1167/iovs.14-15376

Clinical Trials

Factors Affecting Perceptual Thresholds in a Suprachoroidal Retinal Prosthesis Free
PDF
Mohit N. Shivdasani; Nicholas C. Sinclair; Peter N. Dimitrov; Mary Varsamidis; Lauren N. Ayton; Chi D. Luu; Thushara Perera; Hugh J. McDermott; Peter J. Blamey
Tags: implantation procedure, polarity, retina, visual prosthesis, accommodation phosphene
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6467-6481. doi:https://doi.org/10.1167/iovs.14-14396

Perspective

Consensus Statement on the Immunohistochemical Detection of Ocular Lymphatic Vessels Free
PDF
Falk Schroedl; Alexandra Kaser-Eichberger; Simona L. Schlereth; Felix Bock; Birgit Regenfuss; Herbert A. Reitsamer; Gerard A. Lutty; Kazuichi Maruyama; Lu Chen; Elke Lütjen-Drecoll; Reza Dana; Dontscho Kerjaschki; Kari Alitalo; Maria Egle De Stefano; Barbara M. Junghans; Ludwig M. Heindl; Claus Cursiefen
Tags: consensus, lymphatic vessels
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6440-6442. doi:https://doi.org/10.1167/iovs.14-15638

Lecture

Introducing Krzysztof Palczewski, the 2014 Recipient of the Friedenwald Award Free
PDF
Arthur S. Polans
Tags: awards and prizes
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6649-6650. doi:https://doi.org/10.1167/iovs.14-14843
Chemistry and Biology of the Initial Steps in Vision: The Friedenwald Lecture Free
PDF
Krzysztof Palczewski
Tags: proteins, retinoids, rhodopsin, science of chemistry, vision
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6651-6672. doi:https://doi.org/10.1167/iovs.14-15502

Letters to the Editor

Optic Neuropathy Secondary to Spontaneous Intracranial Hypotension (SIH) as Related to Experimental Primate Model Free
PDF
Sylvia L. Groth; Michael S. Lee; Alexander M. McKinney; Bahram Mokri
Tags: intracranial hypotension, optic nerve disorders, primates
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6175-6176. doi:https://doi.org/10.1167/iovs.14-15255
Author Response: Optic Neuropathy Secondary to Spontaneous Intracranial Hypotension (SIH) as Related to Experimental Primate Model Free
PDF
Diya Yang; Jidi Fu; Ruowu Hou; Kegao Liu; Jost B. Jonas; Huaizhou Wang; Weiwei Chen; Zhen Li; Jinghong Sang; Zheng Zhang; Sumeng Liu; Yiwen Cao; Xiaobin Xie; Ruojin Ren; Qingjun Lu; Robert N. Weinreb; Ningli Wang
Tags: intracranial hypotension, optic nerve disorders, primates
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6177. doi:https://doi.org/10.1167/iovs.14-15477
Geographic Atrophy and Cardiovascular Disease Free
PDF
R. Theodore Smith
Tags: atrophy, cardiovascular diseases
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6262. doi:https://doi.org/10.1167/iovs.14-15387
Author Response: Geographic Atrophy and Cardiovascular Disease Free
PDF
Monika Fleckenstein; Steffen Schmitz-Valckenberg; Frank G. Holz
Tags: atrophy, cardiovascular diseases
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6263-6264. doi:https://doi.org/10.1167/iovs.14-15598
Concerns About Peer Review Process Free
PDF
Thomas J. Millar
Tags: peer review
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6450. doi:https://doi.org/10.1167/iovs.14-15377
Author Response: Concerns About Peer Review Process Free
PDF
Jean-Marie A. Parel
Tags: peer review
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6451. doi:https://doi.org/10.1167/iovs.14-15591

Erratum

Erratum Free
PDF
Investigative Ophthalmology & Visual Science October 2014, Vol.55, 6711. doi:https://doi.org/10.1167/iovs.12-11490a
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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