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Editorial

The Impact of IOVS Free
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David C. Beebe
Tags: community, eye, half-life, journal impact factor, ophthalmology
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 6015. doi:https://doi.org/10.1167/iovs.14-15572

Research Highlight

Heterozygous Coding ZNF469 Variants Enriched in New Zealand Patients With Isolated Keratoconus Free
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Elfride De Baere
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5636. doi:https://doi.org/10.1167/iovs.14-15486
Sirt1, A Negative Regulator of Matrix Metalloproteinase-9 in Diabetic Retinopathy Free
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Mojca Globočnik Petrovič
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5661. doi:https://doi.org/10.1167/iovs.14-14874

Anatomy and Pathology/Oncology

Schlemm's Canal Expands After Trabeculectomy in Patients With Primary Angle–Closure Glaucoma Free
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Jiaxu Hong; Yujing Yang; Anji Wei; Sophie X. Deng; Xiangmei Kong; Junyi Chen; Michaël J. A. Girard; Jean Martial Mari; Jianjiang Xu; Xinghuai Sun
Tags: angle closure glaucoma, schlemm's canal, trabeculectomy, intraocular pressure, eye
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5637-5642. doi:https://doi.org/10.1167/iovs.14-14712
Constitutive and LPS-Induced Expression of MCP-1 and IL-8 by Human Uveal Melanocytes In Vitro and Relevant Signal Pathways Free
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Dan-Ning Hu; Mingchao Bi; David Y. Zhang; Fei Ye; Steven A. McCormick; Chi-Chao Chan
Tags: interleukin-8, monocyte chemoattractant protein-1, uvea, melanocytes, mitogen-activated protein kinases
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5760-5769. doi:https://doi.org/10.1167/iovs.14-14685
Prevalence and Implications of TERT Promoter Mutation in Uveal and Conjunctival Melanoma and in Benign and Premalignant Conjunctival Melanocytic Lesions Free
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Anna E. Koopmans; Kimberley Ober; Hendrikus J. Dubbink; Dion Paridaens; Nicole C. Naus; Stephan Belunek; Bart Krist; Edward Post; Ellen C. Zwarthoff; Annelies de Klein; Robert M. Verdijk
Tags: conjunctiva, eye melanomas, malignant melanoma of conjunctiva, mutation, precancerous conditions
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 6024-6030. doi:https://doi.org/10.1167/iovs.14-14901

Biochemistry and Molecular Biology

Activation of Dopamine D2 Receptor Is Critical for the Development of Form-Deprivation Myopia in the C57BL/6 Mouse Free
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Furong Huang; Tingting Yan; Fanjun Shi; Jianhong An; Ruozhong Xie; Fan Zheng; Yuan Li; Jiangfan Chen; Jia Qu; Xiangtian Zhou
Tags: dopamine d2 receptor, mice, myopia, mice, inbred c57bl, sulpiride
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5537-5544. doi:https://doi.org/10.1167/iovs.13-13211
The Combined Effect of Azithromycin and Insulin-Like Growth Factor-1 on Cultured Human Meibomian Gland Epithelial Cells Free
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Yang Liu; Juan Ding
Tags: azithromycin, epithelial cells, insulin-like growth factor i, meibomian gland, lipids
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5596-5601. doi:https://doi.org/10.1167/iovs.14-14782
Loss of Raf-1 Kinase Inhibitory Protein Delays Early-Onset Severe Retinal Ciliopathy in Cep290rd16 Mouse Free
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Balajikarthick Subramanian; Manisha Anand; Naheed W. Khan; Hemant Khanna
Tags: mice, pebp1 gene, proteins, ciliopathies, phenotype
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5788-5794. doi:https://doi.org/10.1167/iovs.14-14954
Elevated Plasma Pentraxin 3 Levels Are Associated With Development and Progression of Diabetic Retinopathy in Korean Patients With Type 2 Diabetes Mellitus Free
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Hyun Seung Yang; Jong Eun Woo; Sung Ju Lee; So Hyun Park; Je Moon Woo
Tags: diabetes mellitus, type 2, diabetic retinopathy, plasma, ptx3 protein, korean
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5989-5997. doi:https://doi.org/10.1167/iovs.14-14864
Deletion of Aryl Hydrocarbon Receptor AHR in Mice Leads to Subretinal Accumulation of Microglia and RPE Atrophy Free
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Soo-Young Kim; Hyun-Jin Yang; Yi-Sheng Chang; Jung-Woong Kim; Matthew Brooks; Emily Y. Chew; Wai T. Wong; Robert N. Fariss; Rivka A. Rachel; Tiziana Cogliati; Haohua Qian; Anand Swaroop
Tags: aryl hydrocarbon receptor, atrophy, mice, microglia, retina
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 6031-6040. doi:https://doi.org/10.1167/iovs.14-15091

Clinical and Epidemiologic Research

Objective Optical Quality and Intraocular Scattering in Myopic Adults Free
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Huamao Miao; Mi Tian; Li He; Jing Zhao; Xiaofen Mo; Xingtao Zhou
Tags: adult, optics, myopia, eye
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5582-5587. doi:https://doi.org/10.1167/iovs.14-14362
Association Between Blood Cadmium Level and Age-Related Macular Degeneration in a Representative Korean Population Free
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Eun Chul Kim; Eunyoung Cho; Donghyun Jee
Tags: cadmium, korean, age-related macular degeneration
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5702-5710. doi:https://doi.org/10.1167/iovs.14-14774
Generational Difference of Refractive Error and Risk Factors in the Handan Offspring Myopia Study Free
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Zhong Lin; Tie Ying Gao; Balamurali Vasudevan; Vishal Jhanji; Kenneth J. Ciuffreda; Peng Zhang; Lei Li; Guang Yun Mao; Ning Li Wang; Yuan Bo Liang
Tags: child, myopia, parent, refractive errors, risk factors
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5711-5717. doi:https://doi.org/10.1167/iovs.13-13693
Accounting for Standard Errors of Vision-Specific Latent Trait in Regression Models Free
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Wan Ling Wong; Xiang Li; Jialiang Li; Tien Yin Wong; Ching-Yu Cheng; Ecosse L. Lamoureux
Tags: regression analysis, standard error, vision, rasch model
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5848-5854. doi:https://doi.org/10.1167/iovs.14-14195
Sunlight Exposure, Pigmentation, and Incident Age-Related Macular Degeneration Free
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Barbara E. K. Klein; Kerri P. Howard; Sudha K. Iyengar; Theru A. Sivakumaran; Kristin J. Meyers; Karen J. Cruickshanks; Ronald Klein
Tags: age-related macular degeneration, eye, eye color, hair color, pigmentation
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5855-5861. doi:https://doi.org/10.1167/iovs.14-14602

Cornea

Decreased DJ-1 Leads to Impaired Nrf2-Regulated Antioxidant Defense and Increased UV-A–Induced Apoptosis in Corneal Endothelial Cells Free
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Cailing Liu; Yuming Chen; Irene E. Kochevar; Ula V. Jurkunas
Tags: antioxidants, apoptosis, chronic exertional compartment syndrome, cornea, down-regulation
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5551-5560. doi:https://doi.org/10.1167/iovs.14-14580
Increased Corneal Epithelial Permeability After Overnight Sleep Free
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Tiana Leung; Yixiu Zhou; Heather M. French; Meng C. Lin
Tags: awakening, cornea, epithelium, permeability, sleep
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5718-5722. doi:https://doi.org/10.1167/iovs.14-14259
The Effect of Standard and High-Fluence Corneal Cross-Linking (CXL) on Cornea and Limbus Free
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Olivier Richoz; David Tabibian; Arthur Hammer; François Majo; Michael Nicolas; Farhad Hafezi
Tags: cornea, corneal collagen cross-linking
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5783-5787. doi:https://doi.org/10.1167/iovs.14-14695
Comparative Transcriptomic Analysis of Cultivated Limbal Epithelium and Donor Corneal Tissue Reveals Altered Wound Healing Gene Expression Free
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Clair Gallagher; Colin Clarke; Sinéad T. Aherne; Kishore R. Katikireddy; Padraig Doolan; Vincent Lynch; Sandra Shaw; Andra Bobart-Hone; Conor Murphy; Martin Clynes; William Power; Finbarr O'Sullivan
Tags: body tissue, cornea, donors, epithelium, gene expression
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5795-5805. doi:https://doi.org/10.1167/iovs.14-14664
Tear Menisci After Laser In Situ Keratomileusis With Mechanical Microkeratome and Femtosecond Laser Free
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Wenjia Xie; Dong Zhang; Jia Chen; Jing Liu; Ye Yu; Liang Hu
Tags: femtosecond pulsed lasers, keratomileusis, laser in situ, knee meniscus, surgical procedures, operative, surgical flaps
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5806-5812. doi:https://doi.org/10.1167/iovs.13-13669
Serine Protease Inhibitor A3K Suppressed the Formation of Ocular Surface Squamous Metaplasia in a Mouse Model of Experimental Dry Eye Free
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Zhirong Lin; Yueping Zhou; Yuqian Wang; Tong Zhou; Jie Li; Pingping Luo; Hui He; Huping Wu; Zuguo Liu
Tags: bronchioloalveolar carcinoma, cornea, dry eye syndromes, metaplasia, mice
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5813-5820. doi:https://doi.org/10.1167/iovs.13-13546
Hyperosmolar Tears Enhance Cooling Sensitivity of the Corneal Nerves in Rats: Possible Neural Basis for Cold-Induced Dry Eye Pain Free
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Harumitsu Hirata; Mark I. Rosenblatt
Tags: cold sensation, cornea, dry eye syndromes, hyperosmolality, hyperosmolar hyperglycemia
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5821-5833. doi:https://doi.org/10.1167/iovs.14-14642
Time Course of Changes in Tear Meniscus Radius and Blink Rate After Instillation of Artificial Tears Free
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Stefan Bandlitz; Christine Purslow; Paul J. Murphy; Heiko Pult
Tags: ocular lubricants, time factors
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5842-5847. doi:https://doi.org/10.1167/iovs.14-14844
CCR7 Is Critical for the Induction and Maintenance of Th17 Immunity in Dry Eye Disease Free
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Shilpa Kodati; Sunil K. Chauhan; Yihe Chen; Thomas H. Dohlman; Parisa Karimian; Daniel Saban; Reza Dana
Tags: antibodies, atrial premature complexes, cornea, dry eye syndromes, immunity
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5871-5877. doi:https://doi.org/10.1167/iovs.14-14481
Pseudomonas aeruginosa Infectious Keratitis in a High Oxygen Transmissible Rigid Contact Lens Rabbit Model Free
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Cynthia Wei; Meifang Zhu; W. Matthew Petroll; Danielle M. Robertson
Tags: contact lenses, cornea, infections, keratitis, lens (device)
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5890-5899. doi:https://doi.org/10.1167/iovs.14-14235
The Resolvin D1 Analogue Controls Maturation of Dendritic Cells and Suppresses Alloimmunity in Corneal Transplantation Free
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Jing Hua; Yiping Jin; Yihe Chen; Takenori Inomata; HyunSoo Lee; Sunil K. Chauhan; Nicos A. Petasis; Charles N. Serhan; Reza Dana
Tags: alloimmunity, cornea, dendritic cells, keratoplasty, t-lymphocytes
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5944-5951. doi:https://doi.org/10.1167/iovs.14-14356
Mesothelial Cells: A Cellular Surrogate for Tissue Engineering of Corneal Endothelium Free
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Christian C. Lachaud; Felipe Soria; Natalia Escacena; Elena Quesada-Hernández; Abdelkrim Hmadcha; Jorge Alió; Bernat Soria
Tags: cardiac support procedures, chronic exertional compartment syndrome, corneal endothelium, mast-cell sarcoma, mesothelial cells
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5967-5978. doi:https://doi.org/10.1167/iovs.14-14706
Mosaicking the Subbasal Nerve Plexus by Guided Eye Movements Free
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Stephan Allgeier; Susanne Maier; Ralf Mikut; Sabine Peschel; Klaus-Martin Reichert; Oliver Stachs; Bernd Köhler
Tags: cornea, eye movement, mosaicism, neurons, single nucleotide polymorphism
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 6082-6089. doi:https://doi.org/10.1167/iovs.14-14698
Comprehensive Assessment of Genetic Variants Within TCF4 in Fuchs' Endothelial Corneal Dystrophy Free
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Eric D. Wieben; Ross A. Aleff; Bruce W. Eckloff; Elizabeth J. Atkinson; Saurabh Baheti; Sumit Middha; William L. Brown; Sanjay V. Patel; Jean-Pierre A. Kocher; Keith H. Baratz
Tags: endothelium, genes, genetics, hereditary corneal dystrophy
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 6101-6107. doi:https://doi.org/10.1167/iovs.14-14958
The Role of Toll-Like Receptor 4 in Corneal Epithelial Wound Healing Free
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Medi Eslani; Asadolah Movahedan; Neda Afsharkhamseh; Herve Sroussi; Ali R. Djalilian
Tags: cornea, epithelium, toll-like receptor 4, wound healing
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 6108-6115. doi:https://doi.org/10.1167/iovs.14-14736

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Wnt and Extraocular Muscle Sparing in Amyotrophic Lateral Sclerosis Free
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Linda K. McLoon; Vahid M. Harandi; Thomas Brännström; Peter M. Andersen; Jing-Xia Liu
Tags: adult, amyotrophic lateral sclerosis, axon, limb, mice
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5482-5496. doi:https://doi.org/10.1167/iovs.14-14886
Age- and Stereovision-Dependent Eye–Hand Coordination Deficits in Children With Amblyopia and Abnormal Binocularity Free
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Simon Grant; Catherine Suttle; Dean R. Melmoth; Miriam L. Conway; John J. Sloper
Tags: amblyopia, child, eye-hand coordination, eye
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5687-5701. doi:https://doi.org/10.1167/iovs.14-14745
HE3286 Reduces Axonal Loss and Preserves Retinal Ganglion Cell Function in Experimental Optic Neuritis Free
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Reas S. Khan; Kimberly Dine; Esteban Luna; Clarence Ahlem; Kenneth S. Shindler
Tags: inflammation, mice, optic nerve, optic neuritis, retinal ganglion cells
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5744-5751. doi:https://doi.org/10.1167/iovs.14-14672

Genetics

Molecular Diagnostic Testing by eyeGENE: Analysis of Patients With Hereditary Retinal Dystrophy Phenotypes Involving Central Vision Loss Free
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Akhila Alapati; Kerry Goetz; John Suk; Mili Navani; Amani Al-Tarouti; Thiran Jayasundera; Santa J. Tumminia; Pauline Lee; Radha Ayyagari
Tags: blindness, diagnostic techniques and procedures, genes, hereditary retinal dystrophy, mutation
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5510-5521. doi:https://doi.org/10.1167/iovs.14-14359
Generation and Characterization of a Murine Model of Bietti Crystalline Dystrophy Free
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Catherine M. Lockhart; Mariko Nakano; Allan E. Rettie; Edward J. Kelly
Tags: crystal structure, lipids, mice, diagnostic imaging, plasma
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5572-5581. doi:https://doi.org/10.1167/iovs.13-13717
Mitochondrial Haplogroups Are Associated With Severity of Diabetic Retinopathy Free
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Christopher B. Estopinal; Isaac M. Chocron; Megan B. Parks; Emily A. Wade; Rachel M. Roberson; L. Goodwin Burgess; Milam A. Brantley, Jr; David C. Samuels
Tags: cohort studies, diabetes mellitus, type 2, diabetic retinopathy, mitochondria, diabetes mellitus
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5589-5595. doi:https://doi.org/10.1167/iovs.14-15149
Mutations in the Zinc Finger Protein Gene, ZNF469, Contribute to the Pathogenesis of Keratoconus Free
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Andrea L. Vincent; Charlotte A. Jordan; Murray J. Cadzow; Tony R. Merriman; Charles N. McGhee
Tags: genes, keratoconus, mutation, pathogenesis, proteins
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5629-5635. doi:https://doi.org/10.1167/iovs.14-14532
Native American Ancestry Is Associated With Severe Diabetic Retinopathy in Latinos Free
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Xiaoyi Gao; W. James Gauderman; Paul Marjoram; Mina Torres; Yii-Der I. Chen; Kent D. Taylor; Jerome I. Rotter; Rohit Varma
Tags: diabetic retinopathy, genetics, hispanics or latinos, native americans, diabetes mellitus, type 2
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 6041-6045. doi:https://doi.org/10.1167/iovs.14-15044

Glaucoma

Differential Effects of Caveolin-1 and -2 Knockdown on Aqueous Outflow and Altered Extracellular Matrix Turnover in Caveolin-Silenced Trabecular Meshwork Cells Free
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Mini Aga; John M. Bradley; Rohan Wanchu; Yong-feng Yang; Ted S. Acott; Kate E. Keller
Tags: catabolism, caveolins, extracellular matrix, fibronectins, perfusion
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5497-5509. doi:https://doi.org/10.1167/iovs.14-14519
Transgenic Mice Expressing Mutated Tyr437His Human Myocilin Develop Progressive Loss of Retinal Ganglion Cell Electrical Responsiveness and Axonopathy With Normal IOP Free
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Tsung-Han Chou; Stanislav Tomarev; Vittorio Porciatti
Tags: axonal neuropathy, intraocular pressure, mice, mice, transgenic, mutation
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5602-5609. doi:https://doi.org/10.1167/iovs.14-14793
Posterior Pole Asymmetry Analyses of Retinal Thickness of Upper and Lower Sectors and Their Association With Peak Retinal Nerve Fiber Layer Thickness in Healthy Young Eyes Free
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Takehiro Yamashita; Taiji Sakamoto; Naoko Kakiuchi; Minoru Tanaka; Yuya Kii; Kumiko Nakao
Tags: eye, retinal nerve fiber layer, fovea centralis, nose
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5673-5678. doi:https://doi.org/10.1167/iovs.13-13828
A Topographical Relationship Between Visual Field Defects and Optic Radiation Changes in Glaucoma Free
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Megha Kaushik; Stuart L. Graham; Chenyu Wang; Alexander Klistorner
Tags: glaucoma, optic radiation, scotoma, visual field defects
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5770-5775. doi:https://doi.org/10.1167/iovs.14-14733
Validating the Sumi Quality of Life Questionnaire With Rasch Analysis Free
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Hiroyo Hirasawa; Hiroshi Murata; Chihiro Mayama; Ryo Asaoka
Tags: disability, questionnaires, rasch model, quality of life, glaucoma
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5776-5782. doi:https://doi.org/10.1167/iovs.14-14390
Anatomic Changes in Schlemm's Canal and Collector Channels in Normal and Primary Open-Angle Glaucoma Eyes Using Low and High Perfusion Pressures Free
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Cheryl R. Hann; Andrew J. Vercnocke; Michael D. Bentley; Steven M. Jorgensen; Michael P. Fautsch
Tags: eye, open-angle glaucoma, perfusion, pressure-physical agent, schlemm's canal
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5834-5841. doi:https://doi.org/10.1167/iovs.14-14128
Photoplethysmographic Measurement of Various Retinal Vascular Pulsation Parameters and Measurement of the Venous Phase Delay Free
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William H. Morgan; Martin L. Hazelton; Brigid D. Betz-Stablein; Dao-Yi Yu; Christopher R. P. Lind; Vignesh Ravichandran; Philip H. House
Tags: retinal vessels, cardiac cycle, eye, harmonics, glaucoma
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5998-6006. doi:https://doi.org/10.1167/iovs.14-15104
Choroidal Thickness and Primary Open-Angle Glaucoma: A Cross-Sectional Study and Meta-Analysis Free
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Wei Wang; Xiulan Zhang
Tags: meta-analysis, open-angle glaucoma
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 6007-6014. doi:https://doi.org/10.1167/iovs.14-14996

Immunology and Microbiology

Long-Term Therapeutic Effects of Mesenchymal Stem Cells Compared to Dexamethasone on Recurrent Experimental Autoimmune Uveitis of Rats Free
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Lingjun Zhang; Hui Zheng; Hui Shao; Hong Nian; Yan Zhang; Lingling Bai; Chang Su; Xun Liu; Lijie Dong; Xiaorong Li; Xiaomin Zhang
Tags: autoimmune diseases, autoimmunity, dexamethasone, rats, recurrence
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5561-5571. doi:https://doi.org/10.1167/iovs.14-14788
Restoring Conjunctival Tolerance by Topical Nuclear Factor–κB Inhibitors Reduces Preservative-Facilitated Allergic Conjunctivitis in Mice Free
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Mauricio Guzmán; Florencia Sabbione; María Laura Gabelloni; Silvia Vanzulli; Analía Silvina Trevani; Mirta Nilda Giordano; Jeremías Gastón Galletti
Tags: allergic conjunctivitis, benzalkonium chloride, conjunctiva, eyedrops, mice
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 6116-6126. doi:https://doi.org/10.1167/iovs.14-14075

Low Vision

Baseline Risk Factors for Incidence of Blindness in a South Indian Population: The Chennai Eye Disease Incidence Study Free
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Lingam Vijaya; Rashima Asokan; Manish Panday; Nikhil S. Choudhari; Sathyamangalam Ve Ramesh; Lokapavani Velumuri; Sachi Devi Boddupalli; Govindan T. Sunil; Ronnie George
Tags: blindness, eye diseases, risk factors, india, incidence
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5545-5550. doi:https://doi.org/10.1167/iovs.14-14614

Multidisciplinary Ophthalmic Imaging

Automated Volumetric Analysis of Interface Fluid in Descemet Stripping Automated Endothelial Keratoplasty Using Intraoperative Optical Coherence Tomography Free
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David Xu; William J. Dupps, Jr; Sunil K. Srivastava; Justis P. Ehlers
Tags: cornea, descemet stripping endothelial keratoplasty, endothelium, intraoperative care, keratoplasty
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5610-5615. doi:https://doi.org/10.1167/iovs.14-14346
Magic Angle–Enhanced MRI of Fibrous Microstructures in Sclera and Cornea With and Without Intraocular Pressure Loading Free
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Leon C. Ho; Ian A. Sigal; Ning-Jiun Jan; Alexander Squires; Zion Tse; Ed X. Wu; Seong-Gi Kim; Joel S. Schuman; Kevin C. Chan
Tags: body tissue, cornea, eye, intraocular pressure, magnetic resonance imaging
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5662-5672. doi:https://doi.org/10.1167/iovs.14-14561

Nantotechnology and Regenerative Medicine

Repair of Canine Medial Orbital Bone Defects With miR-31–Modified Bone Marrow Mesenchymal Stem Cells Free
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Yuan Deng; Huifang Zhou; Ping Gu; Xianqun Fan
Tags: bone marrow, dog, domestic, mesenchymal stem cells, x-ray microtomography, zygomatic bones
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 6016-6023. doi:https://doi.org/10.1167/iovs.14-14977

Physiology and Pharmacology

Vascular Dysfunction in Ocular Blood Flow Regulation: Impact of Reactive Oxygen Species in an Experimental Setup Free
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Lars Wagenfeld; Sonja Weiss; Maren Klemm; Gisbert Richard; Oliver Zeitz
Tags: adenosine triphosphatases, endothelium, membrane potentials, pathophysiology, reactive oxygen species
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5531-5536. doi:https://doi.org/10.1167/iovs.14-14032
Effect of Tanshinone IIA in an In Vitro Model of Graves' Orbitopathy Free
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Soolienah Rhiu; Min Kyung Chae; Eun Jig Lee; Jong Bok Lee; Jin Sook Yoon
Tags: fibroblasts
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5900-5910. doi:https://doi.org/10.1167/iovs.14-14008

Retina

Retinal Ischemia/Reperfusion Injury Is Mediated by Toll-like Receptor 4 Activation of NLRP3 Inflammasomes Free
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Yun Qi; Min Zhao; Yujing Bai; Lvzhen Huang; Wenzhen Yu; Zongmei Bian; Mingwei Zhao; Xiaoxin Li
Tags: inflammasomes, toll-like receptor 4, wounds and injuries, retina, retinal ischemia
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5466-5475. doi:https://doi.org/10.1167/iovs.14-14380
Flicker-Induced Retinal Arteriole Dilation Is Reduced by Ambient Lighting Free
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Jonathan E. Noonan; Gregory J. Dusting; Thanh T. Nguyen; Ryan E. K. Man; William J. Best; Ecosse L. Lamoureux
Tags: arteriole, dilatation, pathologic, lighting, photopsia
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5476-5481. doi:https://doi.org/10.1167/iovs.14-14940
Wnt Modulators in the Aqueous Humor Are Associated With Outer Retinal Damage Severity in Patients With Neovascular Age-Related Macular Degeneration Free
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Kyu Hyung Park; Ae Jin Choi; Jeehyun Yoon; Daehan Lim; Se Joon Woo; Sang Jun Park; Hyung Chan Kim; Hyewon Chung
Tags: aqueous humor, enzyme-linked immunosorbent assay, exudative age-related macular degeneration, hypertension, retina
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5522-5530. doi:https://doi.org/10.1167/iovs.14-14566
Fundus Autofluorescence and Photoreceptor Cell Rosettes in Mouse Models Free
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Erin Flynn; Keiko Ueda; Emily Auran; Jack M. Sullivan; Janet R. Sparrow
Tags: fundus autofluorescence imaging, mice, photoreceptors, high pressure liquid chromatography procedure
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5643-5652. doi:https://doi.org/10.1167/iovs.14-14136
Choroidal and Retinal Thickening in Severe Preeclampsia Free
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Aakriti Garg; Ronald J. Wapner; Cande V. Ananth; Elizabeth Dale; Stephen H. Tsang; Winston Lee; Rando Allikmets; Srilaxmi Bearelly
Tags: diagnostic imaging, pre-eclampsia, severe pre-eclampsia, protein electrophoresis, serum, postpartum period
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5723-5729. doi:https://doi.org/10.1167/iovs.14-14143
A Prospective Longitudinal Study of Retinal Structure and Function in Achromatopsia Free
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Jonathan Aboshiha; Adam M. Dubis; Jill Cowing; Rachel T. A. Fahy; Venki Sundaram; James W. Bainbridge; Robin R. Ali; Alfredo Dubra; Marko Nardini; Andrew R. Webster; Anthony T. Moore; Gary Rubin; Joseph Carroll; Michel Michaelides
Tags: achromatopsia, follow-up, fundus autofluorescence imaging, natural history, prospective studies
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5733-5743. doi:https://doi.org/10.1167/iovs.14-14937
Beraprost Sodium, a Stable Prostacyclin Analogue, Elicits Dilation of Isolated Porcine Retinal Arterioles: Roles of eNOS and Potassium Channels Free
PDF
Shinji Ono; Taiji Nagaoka; Tsuneaki Omae; Ichiro Tanano; Takayuki Kamiya; Shinichi Otani; Akihiro Ishibazawa; Akitoshi Yoshida
Tags: arteriole, dilatation, pathologic, epoprostenol, nitric oxide synthase, potassium channel
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5752-5759. doi:https://doi.org/10.1167/iovs.14-14902
The Staining Pattern of Brilliant Blue G During Macular Hole Surgery: A Clinicopathologic Study Free
PDF
David H. W. Steel; Christiana Dinah; Haifa Magdi; Kathryn White; Jon Rees
Tags: body tissue, brilliant blue g, postoperative care, repair of hole of macula lutea, vitreous body
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5924-5931. doi:https://doi.org/10.1167/iovs.14-14809
High-Resolution Imaging of Photoreceptors in Macular Microholes Free
PDF
Sotaro Ooto; Masanori Hangai; Kohei Takayama; Naoko Ueda-Arakawa; Yukiko Makiyama; Masaaki Hanebuchi; Nagahisa Yoshimura
Tags: diagnostic imaging, eye, fovea centralis, photoreceptors, retinal cone
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5932-5943. doi:https://doi.org/10.1167/iovs.13-13792
In Vivo Adaptive Optics Imaging of the Temporal Raphe and Its Relationship to the Optic Disc and Fovea in the Human Retina Free
PDF
Gang Huang; Thomas J. Gast; Stephen A. Burns
Tags: diagnostic imaging, fovea centralis, optic disk, optics, retina
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5952-5961. doi:https://doi.org/10.1167/iovs.14-14893
Mathematical Analysis of the Normal Anatomy of the Aging Fovea Free
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Brooke Nesmith; Akash Gupta; Taylor Strange; Yuval Schaal; Shlomit Schaal
Tags: aging, fovea centralis, mathematics
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5962-5966. doi:https://doi.org/10.1167/iovs.14-15278
Association of Focal Choroidal Excavation With Age-Related Macular Degeneration Free
PDF
Yoshimasa Kuroda; Akitaka Tsujikawa; Sotaro Ooto; Kenji Yamashiro; Akio Oishi; Hideo Nakanishi; Kyoko Kumagai; Masayuki Hata; Shigeta Arichika; Abdallah A. Ellabban; Nagahisa Yoshimura
Tags: age-related macular degeneration, choroidal neovascularization, eye, functional capacity evaluation, fundus photography
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 6046-6054. doi:https://doi.org/10.1167/iovs.14-14723
Response of Inner Retinal Oxygen Extraction Fraction to Light Flicker Under Normoxia and Hypoxia in Rat Free
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Pang-yu Teng; Justin Wanek; Norman P. Blair; Mahnaz Shahidi
Tags: hypoxia, oxygen extraction, photopsia, oxygen
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 6055-6058. doi:https://doi.org/10.1167/iovs.13-13811
Longitudinal Structure/Function Analysis in Reticular Pseudodrusen Free
PDF
Florian Alten; Peter Heiduschka; Christoph R. Clemens; Nicole Eter
Tags: electroretinography, eye, follow-up, fovea centralis, phenotype
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 6073-6081. doi:https://doi.org/10.1167/iovs.13-13804

Retinal Cell Biology

The Mitochondrial Complex I Inhibitor Rotenone Induces Endoplasmic Reticulum Stress and Activation of GSK-3β in Cultured Rat Retinal Cells Free
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Guoge Han; Robert J. Casson; Glyn Chidlow; John P. M. Wood
Tags: rotenone, stress, neuroglia, mitochondria
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5616-5628. doi:https://doi.org/10.1167/iovs.14-14371
Sirt1, a Negative Regulator of Matrix Metalloproteinase-9 in Diabetic Retinopathy Free
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Renu A. Kowluru; Julia M. Santos; Qing Zhong
Tags: diabetic retinopathy, gelatinase b, diabetes mellitus, retina, glucose
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5653-5660. doi:https://doi.org/10.1167/iovs.14-14383
TAK1 Inhibition Accelerates Cellular Senescence of Retinal Pigment Epithelial Cells Free
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Zeev Dvashi; Yaron Green; Ayala Pollack
Tags: aging, cellular senescence, older adult, phosphotransferases, retinal pigment cell
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5679-5686. doi:https://doi.org/10.1167/iovs.14-14349
NF-κB–Mediated Nitric Oxide Production and Activation of Caspase-3 Cause Retinal Ganglion Cell Death in the Hypoxic Neonatal Retina Free
PDF
Gurugirijha Rathnasamy; Viswanathan Sivakumar; Parakalan Rangarajan; Wallace S. Foulds; Eng Ang Ling; Charanjit Kaur
Tags: caspase-3, hypoxia, retina, nitric oxide, apoptosis
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5878-5889. doi:https://doi.org/10.1167/iovs.13-13718
Egr-1 mRNA Expression Is a Marker for the Direction of Mammalian Ocular Growth Free
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Regan S. Ashby; Guang Zeng; Amelia J. Leotta; Dennis Y. Tse; Sally A. McFadden
Tags: guinea, lens (device), lens, crystalline, mammals, myopia
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5911-5921. doi:https://doi.org/10.1167/iovs.13-11708
Systemic Administration of the Antioxidant/Iron Chelator α-Lipoic Acid Protects Against Light-Induced Photoreceptor Degeneration in the Mouse Retina Free
PDF
Liangliang Zhao; Chenguang Wang; Delu Song; Yafeng Li; Ying Song; Guanfang Su; Joshua L. Dunaief
Tags: antioxidants, iron chelating agents, mice, photoreceptors, retina
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5979-5988. doi:https://doi.org/10.1167/iovs.14-15025
Loss of Outer Retinal Neurons and Circuitry Alterations in the DBA/2J Mouse Free
PDF
Laura Fernández-Sánchez; Luis Pérez de Sevilla Müller; Nicholas C. Brecha; Nicolás Cuenca
Tags: horizontal cells, mice, neurons, photoreceptors, retina
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 6059-6072. doi:https://doi.org/10.1167/iovs.14-14421
Endocytosis of Tight Junctions Caveolin Nitrosylation Dependent Is Improved by Cocoa Via Opioid Receptor on RPE Cells in Diabetic Conditions Free
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Mariana Aparecida B. Rosales; Kamila Cristina Silva; Diego A. Duarte; Franco Aparecido Rossato; José B. Lopes de Faria; Jacqueline M. Lopes de Faria
Tags: caveolins, cocoa, diabetes mellitus, endocytosis, opioid receptor
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 6090-6100. doi:https://doi.org/10.1167/iovs.14-14234

Visual Psychophysics and Physiological Optics

Effects of Pupil Center Shift on Ocular Aberrations Free
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David A. Atchison; Ankit Mathur
Tags: pupil, refraction
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5862-5870. doi:https://doi.org/10.1167/iovs.14-14212

Letters to the Editor

Caveats to Obtaining Retinal Topography With Optical Coherence Tomography Free
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Anthony N. Kuo; Oscar Carrasco-Zevallos; Cynthia A. Toth; Joseph A. Izatt
Tags: optical coherence tomography
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5730-5731. doi:https://doi.org/10.1167/iovs.14-15212
Author Response: Caveats to Obtaining Retinal Topography With Optical Coherence Tomography Free
PDF
Jaeryung Oh
Tags: optical coherence tomography
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5732. doi:https://doi.org/10.1167/iovs.14-15386
Relationship Between Foveal Cone Specialization and Pit Morphology in Albinism Free
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Alan D. Springer
Tags: albinism, language morphology, morphology, retinal cone
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5922. doi:https://doi.org/10.1167/iovs.14-15383
Author Response: Relationship Between Foveal Cone Specialization and Pit Morphology in Albinism Free
PDF
Melissa A. Wilk; Alfredo Dubra; Christine A. Curcio; Murray H. Brilliant; C. Gail Summers; Joseph Carroll
Tags: albinism, language morphology, morphology, retinal cone
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5923. doi:https://doi.org/10.1167/iovs.14-15470

Erratum

Erratum Free
PDF
Investigative Ophthalmology & Visual Science September 2014, Vol.55, 5588. doi:https://doi.org/10.1167/iovs.13-13166a
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