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Research Highlight

Quantifying Structures in the Ocular Fundus Free
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Douglas R. Anderson; Claude Burgoyne
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4531. doi:https://doi.org/10.1167/iovs.12-10253

Anatomy and Pathology/Oncology

JARID1B Protein Expression and Prognostic Implications in Uveal Melanoma Free
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Patrik Radberger; Agatha Radberger; Vladimir J. N. Bykov; Stefan Seregard; Mario A. Economou
Tags: melanoma, neoplasms, proteins, uveal melanoma
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4442-4449. doi:https://doi.org/10.1167/iovs.11-9296
Impact of Repeated Topical-Loaded Manganese-Enhanced MRI on the Mouse Visual System Free
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Shu-Wei Sun; Tiffany Thiel; Hsiao-Fang Liang
Tags: magnetic resonance imaging, manganese, mice, optic nerve, visual system
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4699-4709. doi:https://doi.org/10.1167/iovs.12-9715

Biochemistry and Molecular Biology

Ceramide Kinase-Like (CERKL) Interacts with Neuronal Calcium Sensor Proteins in the Retina in a Cation-Dependent Manner Free
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Mariela J. Nevet; Sharon Vekslin; Alexander M. Dizhoor; Elena V. Olshevskaya; Rotem Tidhar; Anthony H. Futerman; Tamar Ben-Yosef
Tags: calcium, cations, ceramides, phosphotransferases, proteins
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4565-4574. doi:https://doi.org/10.1167/iovs.12-9770
Leber's Hereditary Optic Neuropathy Is Associated with the T3866C Mutation in Mitochondrial ND1 Gene in Three Han Chinese Families Free
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Xiangtian Zhou; Yaping Qian; Juanjuan Zhang; Yi Tong; Pingping Jiang; Min Liang; Xianning Dai; Huihui Zhou; Fuxin Zhao; Yanchun Ji; Jun Qin Mo; Jia Qu; Min-Xin Guan
Tags: cell lines, chinese (other dialects), chinese people, dna, mitochondrial, family
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4586-4594. doi:https://doi.org/10.1167/iovs.11-9109
Surface Chemistry Study of the Interactions of Pharmaceutical Ingredients with Human Meibum Films Free
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Georgi A. Georgiev; Norihiko Yokoi; Slavyana Ivanova; Rumen Krastev; Zdravko Lalchev
Tags: bacterial artificial chromosomes, blood alcohol concentration, bronchioloalveolar carcinoma, compression, eyedrops
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4605-4615. doi:https://doi.org/10.1167/iovs.12-9907
Differential Expression of Fourteen Proteins between Uveal Melanoma from Patients Who Subsequently Developed Distant Metastases versus Those Who Did Not Free
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Annett Linge; Susan Kennedy; Deirdre O'Flynn; Stephen Beatty; Paul Moriarty; Michael Henry; Martin Clynes; Annemarie Larkin; Paula Meleady
Tags: proteins, uveal melanoma, fatty acid binding protein 3, neoplasm metastasis, metastasis, distant
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4634-4643. doi:https://doi.org/10.1167/iovs.11-9019
Species Variation in Small Molecule Components of Animal Vitreous Free
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Jenifer Mains; Lay Ean Tan; Tong Zhang; Louise Young; Ruiwen Shi; Clive Wilson
Tags: small molecule, vitreous body, acetylcholinesterase, oryctolagus cuniculus, body tissue
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4778-4786. doi:https://doi.org/10.1167/iovs.12-9998
Pattern of Expression of p53, Its Family Members, and Regulators during Early Ocular Development and in the Post-Mitotic Retina Free
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Linda Vuong; Daniel E. Brobst; Anisse Saadi; Ivana Ivanovic; Muayyad R. Al-Ubaidi
Tags: eye development, family, proteins, retina, polymerase chain reaction
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4821-4831. doi:https://doi.org/10.1167/iovs.11-8681

Clinical and Epidemiologic Research

A New Epidemiological Aid in Deciding Whether to Continue or Stop a Treatment Free
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Mari Elshout; Margriet I. van der Reis; Carroll A. B. Webers; Ellen C. La Heij; Fred Hendrikse; Jan S. A. G. Schouten
Tags: visual acuity, follow-up, intraocular pressure, convergence insufficiency, weight measurement scales
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4331-4336. doi:https://doi.org/10.1167/iovs.11-9242
The Association between Time Spent Outdoors and Myopia Using a Novel Biomarker of Outdoor Light Exposure Free
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Justin C. Sherwin; Alex W. Hewitt; Minas T. Coroneo; Lisa S. Kearns; Lyn R. Griffiths; David A. Mackey
Tags: biological markers, conjunctiva, myopia, autofluorescence, light exposure
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4363-4370. doi:https://doi.org/10.1167/iovs.11-8677
Prevalence and Associated Risk Factors of Myopic Maculopathy in Elderly Chinese: The Shihpai Eye Study Free
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Shih-Jen Chen; Ching-Yu Cheng; An-Fei Li; Kai-Ling Peng; Pesus Chou; Shih-Hwa Chiou; Wen-Ming Hsu
Tags: chinese people, eye, macular disorders, older adult, prevalence
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4868-4873. doi:https://doi.org/10.1167/iovs.12-9919
Topography of Geographic Atrophy in Age-Related Macular Degeneration Free
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Matthias M. Mauschitz; Sofia Fonseca; Petrus Chang; Arno P. Göbel; Monika Fleckenstein; Glenn J. Jaffe; Frank G. Holz; Steffen Schmitz-Valckenberg; for the GAP Study Group
Tags: atrophy, age-related macular degeneration
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4932-4939. doi:https://doi.org/10.1167/iovs.12-9711
The Heritability of Macular Response to Supplemental Lutein and Zeaxanthin: A Classic Twin Study Free
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Christopher J. Hammond; S. H. Melissa Liew; Frederik J. Van Kuijk; Stephen Beatty; John M. Nolan; Tim D. Spector; Clare E. Gilbert
Tags: carotenoids, lutein, twin studies, twins, diet
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4963-4968. doi:https://doi.org/10.1167/iovs.12-9618
Devising Two-Stage and Multistage Phase II Studies on Systemic Adjuvant Therapy for Uveal Melanoma Free
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John Whitehead; Svetlana Tishkovskaya; Jemma O'Connor; Bertil Damato
Tags: adjuvant therapy, phase 2 clinical trials, sample size, uveal melanoma, research design
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4986-4989. doi:https://doi.org/10.1167/iovs.12-9858
Myopia Control with Orthokeratology Contact Lenses in Spain: Refractive and Biometric Changes Free
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Jacinto Santodomingo-Rubido; César Villa-Collar; Bernard Gilmartin; Ramón Gutiérrez-Ortega
Tags: biometry, myopia, orthokeratology, orthokeratology contact lenses, spain
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 5060-5065. doi:https://doi.org/10.1167/iovs.11-8005

Cornea

Anti-Inflammatory Effects of Alpha Linolenic Acid on Human Corneal Epithelial Cells Free
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Nir Erdinest; Or Shmueli; Yoni Grossman; Haim Ovadia; Abraham Solomon
Tags: alpha-linolenic acid, anti-inflammatory agents, corneal epithelial cells, cytokine, interleukin-6
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4396-4406. doi:https://doi.org/10.1167/iovs.12-9724
Changes in Diadenosine Polyphosphates during Alignment-Fit and Orthokeratology Rigid Gas Permeable Lens Wear Free
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Gonzalo Carracedo; José Manuel González-Méijome; Jesús Pintor
Tags: lens (device), lens, crystalline, muscle rigidity, orthokeratology, polyphosphates
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4426-4432. doi:https://doi.org/10.1167/iovs.11-9342
Semaphorin 7a Links Nerve Regeneration and Inflammation in the Cornea Free
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Abed Namavari; Shweta Chaudhary; Okan Ozturk; Jin-Hong Chang; Lisette Yco; Snehal Sonawane; Neelima Katam; Vishakha Khanolkar; Joelle Hallak; Joy Sarkar; Sandeep Jain
Tags: cornea, nerve regeneration, semaphorins, inflammation
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4575-4585. doi:https://doi.org/10.1167/iovs.12-9760
Analysis of Comparison of Human Meibomian Lipid Films and Mixtures with Cholesteryl Esters In Vitro Films using High Resolution Color Microscopy Free
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Thomas J. Millar; P. Ewen King-Smith
Tags: cholesterol esters, color, lipids
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4710-4719. doi:https://doi.org/10.1167/iovs.12-10022
uPA Binding to PAI-1 Induces Corneal Myofibroblast Differentiation on Vitronectin Free
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Lingyan Wang; Christine M. Ly; Chun-Ying Ko; Erin E. Meyers; Daniel A. Lawrence; Audrey M. Bernstein
Tags: plasminogen activator inhibitor 1, urokinase, vitronectin, cornea, integrins
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4765-4775. doi:https://doi.org/10.1167/iovs.12-10042
Anterior Chamber Dimensions and Posterior Corneal Arc Length in Malay Eyes: An Anterior Segment Optical Coherence Tomography Study Free
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Deborah K. L. Tan; Wesley Chong; Wan Ting Tay; Leonard H. Yuen; Mingguang He; Tin Aung; Donald T. H. Tan; Tien Yin Wong; Jodhbir S. Mehta
Tags: anterior chamber of eye, cornea, eye, optical coherence tomography
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4860-4867. doi:https://doi.org/10.1167/iovs.12-9787
The Relationship between Subbasal Nerve Morphology and Corneal Sensation in Ocular Surface Disease Free
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Antoine Labbé; Haiyan Alalwani; Charles Van Went; Emmanuelle Brasnu; Dan Georgescu; Christophe Baudouin
Tags: cornea, language morphology, morphology, neurons, sensory perception
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4926-4931. doi:https://doi.org/10.1167/iovs.11-8708
Abnormalities of Stromal Structure in the Bullous Keratopathy Cornea Identified by Second Harmonic Generation Imaging Microscopy Free
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Naoyuki Morishige; Norihiro Yamada; Xu Zhang; Yukiko Morita; Naoyuki Yamada; Kazuhiro Kimura; Atsushi Takahara; Koh-Hei Sonoda
Tags: bullous keratopathy, cornea, diagnostic imaging, edema, harmonics
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4998-5003. doi:https://doi.org/10.1167/iovs.12-10214
Corneal Biomechanical Properties from Two-Dimensional Corneal Flap Extensiometry: Application to UV-Riboflavin Cross-Linking Free
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Sabine Kling; Harilaos Ginis; Susana Marcos
Tags: cornea, corneal collagen cross-linking, riboflavin, surgical flaps, 5-lipoxygenase-activating protein
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 5010-5015. doi:https://doi.org/10.1167/iovs.12-9583
SERPINA3K Protects against Oxidative Stress via Modulating ROS Generation/Degradation and KEAP1-NRF2 Pathway in the Corneal Epithelium Free
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Tong Zhou; Rongrong Zong; Zhoujing Zhang; Chengpeng Zhu; Fangyu Pan; Xinye Xiao; Zhen Liu; Hui He; Jian-xing Ma; Zuguo Liu; Yueping Zhou
Tags: antioxidants, catabolism, corneal epithelium, oxidative stress, western blotting
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 5033-5043. doi:https://doi.org/10.1167/iovs.12-9729
iTRAQ Quantitative Proteomics in the Analysis of Tears in Dry Eye Patients Free
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Sruthi Srinivasan; Mirunalni Thangavelu; Liwen Zhang; Kari B. Green; Kelly K. Nichols
Tags: dry eye syndromes, proteins, proteomics, muramidase
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 5052-5059. doi:https://doi.org/10.1167/iovs.11-9022
Changes in Mouse Corneal Epithelial Innervation with Age Free
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Cun Wang; Ting Fu; Chaoyong Xia; Zhijie Li
Tags: cornea, epithelium, mice, nerve fibers, nerve supply
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 5077-5084. doi:https://doi.org/10.1167/iovs.12-9704

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Effects of Induced Monocular Blur versus Anisometropic Amblyopia on Saccades, Reaching, and Eye-Hand Coordination Free
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Ewa Niechwiej-Szwedo; Sean A. Kennedy; Linda Colpa; Manokaraananthan Chandrakumar; Herbert C. Goltz; Agnes M. F. Wong
Tags: amblyopia, anisometropic amblyopia, eye-hand coordination, saccades, eye
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4354-4362. doi:https://doi.org/10.1167/iovs.12-9855
Three-Dimensional Display-Induced Transient Myopia and the Difference in Myopic Shift between Crossed and Uncrossed Disparities Free
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Young-Woo Suh; Jaeryung Oh; Hyo-Myung Kim; Yoonae A Cho; Jong-Suk Song
Tags: myopia transient, uncrossed disparity, myopia, refractive errors, crossed disparity
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 5029-5032. doi:https://doi.org/10.1167/iovs.12-9588

Genetics

Retinal Phenotypes in Patients Homozygous for the G1961E Mutation in the ABCA4 Gene Free
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Tomas R. Burke; Gerald A. Fishman; Jana Zernant; Carl Schubert; Stephen H. Tsang; R. Theodore Smith; Radha Ayyagari; Robert K. Koenekoop; Allison Umfress; Maria Laura Ciccarelli; Alfonso Baldi; Alessandro Iannaccone; Frans P. M. Cremers; Caroline C. W. Klaver; Rando Allikmets
Tags: genes, homozygote, mutation, phenotype
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4458-4467. doi:https://doi.org/10.1167/iovs.11-9166
Genome-Wide Analysis of Central Corneal Thickness in Primary Open-Angle Glaucoma Cases in the NEIGHBOR and GLAUGEN Consortia Free
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Megan Ulmer; Jun Li; Brian L. Yaspan; Ayse Bilge Ozel; Julia E. Richards; Sayoko E. Moroi; Felicia Hawthorne; Donald L. Budenz; David S. Friedman; Douglas Gaasterland; Jonathan Haines; Jae H. Kang; Richard Lee; Paul Lichter; Yutao Liu; Louis R. Pasquale; Margaret Pericak-Vance; Anthony Realini; Joel S. Schuman; Kuldev Singh; Douglas Vollrath; Robert Weinreb; Gadi Wollstein; Donald J. Zack; Kang Zhang; Terri Young; R. Rand Allingham; Janey L. Wiggs; Allison Ashley-Koch; Michael A. Hauser
Tags: cornea, genome-wide association study, open-angle glaucoma
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4468-4474. doi:https://doi.org/10.1167/iovs.12-9784
A Novel GUCY2D Mutation, V933A, Causes Central Areolar Choroidal Dystrophy Free
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Anne E. Hughes; Weihua Meng; Andrew J. Lotery; Declan T. Bradley
Tags: mutation, family
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4748-4753. doi:https://doi.org/10.1167/iovs.12-10061
A Genotype-Phenotype Comparison of ADAMTSL4 and FBN1 in Isolated Ectopia Lentis Free
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Aman Chandra; Jose A. Aragon-Martin; Kathryn Hughes; Sabiha Gati; M. Ashwin Reddy; Charu Deshpande; Graham Cormack; Anne H. Child; David G. Charteris; Gavin Arno
Tags: ectopia lentis, genotype, mutation, phenotype, cornea
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4889-4896. doi:https://doi.org/10.1167/iovs.12-9874
Association of C2 and CFB Polymorphisms with Anterior Uveitis Free
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Ming-ming Yang; Timothy Y. Y. Lai; Pancy O. S. Tam; Sylvia W. Y. Chiang; Tsz Kin Ng; Ke Liu; Chi Pui Pang
Tags: polymorphism, single nucleotide polymorphism, uveitis, anterior, hla-b27 antigen, haplotypes
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4969-4974. doi:https://doi.org/10.1167/iovs.12-9478
Genetic Factors for Choroidal Neovascularization Associated with High Myopia Free
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Nicolas Leveziel; Yi Yu; Robyn Reynolds; Albert Tai; Weihua Meng; Violaine Caillaux; Patrick Calvas; Bernard Rosner; François Malecaze; Eric H. Souied; Johanna M. Seddon
Tags: choroidal neovascularization, genetic aspects, myopia, single nucleotide polymorphism
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 5004-5009. doi:https://doi.org/10.1167/iovs.12-9538

Glaucoma

Detection of Localized Retinal Nerve Fiber Layer Defects with Posterior Pole Asymmetry Analysis of Spectral Domain Optical Coherence Tomography Free
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Je Hyun Seo; Tae-Woo Kim; Robert N. Weinreb; Ki Ho Park; Seok Hwan Kim; Dong Myung Kim
Tags: glaucoma, optical coherence tomography, retinal nerve fiber layer, sensitivity and specificity, photography
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4347-4353. doi:https://doi.org/10.1167/iovs.12-9673
Thickness, Phase Retardation, Birefringence, and Reflectance of the Retinal Nerve Fiber Layer in Normal and Glaucomatous Non-Human Primates Free
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Jordan Dwelle; Shuang Liu; Bingqing Wang; Austin McElroy; Derek Ho; Mia K. Markey; Thomas Milner; H. Grady Rylander, III
Tags: birefringence, glaucoma, primates, retinal nerve fiber layer, eye
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4380-4395. doi:https://doi.org/10.1167/iovs.11-9130
The Effects of Peripapillary Atrophy on the Diagnostic Ability of Stratus and Cirrus OCT in the Analysis of Optic Nerve Head Parameters and Disc Size Free
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Sun Young Kim; Hae-Young L. Park; Chan Kee Park
Tags: atrophy, glaucoma, optic disk, retinal nerve fiber layer, eye
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4475-4484. doi:https://doi.org/10.1167/iovs.12-9682
Glaucoma Progression in Eyes with a History of Refractive Corneal Surgery Free
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Yoon Jeon Kim; Sung-Cheol Yun; Jung Hwa Na; Hung Won Tchah; Jong Jin Jung; Kyung Rim Sung
Tags: eye, glaucoma, medical history, operative procedure on cornea, surgical ocular refractive procedure
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4485-4489. doi:https://doi.org/10.1167/iovs.12-9862
Reproducibility of Macular, Retinal Nerve Fiber Layer, and ONH Measurements by OCT in Rhesus Monkeys: The Beijing Intracranial and Intraocular Pressure (iCOP) Study Free
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Zheng Zhang; Diya Yang; Jinhong Sang; Ruowu Hou; Kegao Liu; Zhen Li; Xiaobin Xie; Jost B. Jonas; Ningli Wang
Tags: cercopithecidae, eye, intraocular pressure, macaca mulatta, optic disk
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4505-4509. doi:https://doi.org/10.1167/iovs.12-9439
Measurement of Optic Disc Size and Rim Area with Spectral-Domain OCT and Scanning Laser Ophthalmoscopy Free
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Sasan Moghimi; Hamid Hosseini; Jay Riddle; Gina Yoo Lee; Elena Bitrian; JoAnn Giaconi; Joseph Caprioli; Kouros Nouri-Mahdavi
Tags: diagnostic imaging, eye, magnification, optic disk, scanning laser ophthalmoscopy
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4519-4530. doi:https://doi.org/10.1167/iovs.11-8362
Perturbation of Hyaluronan Synthesis in the Trabecular Meshwork and the Effects on Outflow Facility Free
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Kate E. Keller; Ying Ying Sun; Yong-Feng Yang; John M. Bradley; Ted S. Acott
Tags: enzyme-linked immunosorbent assay, eye, genes, hyaluronan, lentivirus
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4616-4625. doi:https://doi.org/10.1167/iovs.12-9500
Rac1 Inhibition Prevents Tissue Contraction and MMP Mediated Matrix Remodeling in the Conjunctiva Free
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Victoria E. Tovell; Chi Y. Chau; Peng T. Khaw; Maryse Bailly
Tags: body tissue, collagen, conjunctiva, gel, interstitial collagenase
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4682-4691. doi:https://doi.org/10.1167/iovs.11-8577
Wide 3-Dimensional Macular Ganglion Cell Complex Imaging with Spectral-Domain Optical Coherence Tomography in Glaucoma Free
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Satoshi Morooka; Masanori Hangai; Masayuki Nukada; Noriko Nakano; Kohei Takayama; Yugo Kimura; Tadamichi Akagi; Hanako Ohashi Ikeda; Atsushi Nonaka; Nagahisa Yoshimura
Tags: diagnostic imaging, ganglia, glaucoma, optical coherence tomography, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4805-4812. doi:https://doi.org/10.1167/iovs.12-9870
Characteristics of Optic Disc Morphology in Glaucoma Patients with Parafoveal Scotoma Compared to Peripheral Scotoma Free
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Kyoung In Jung; Hae-Young L. Park; Chan Kee Park
Tags: glaucoma, language morphology, morphology, optic disk, parafoveal region
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4813-4820. doi:https://doi.org/10.1167/iovs.12-9908
Induction and Mechanism of Apoptosis by Hydroxycamptothecin in Human Tenon's Capsule Fibroblasts Free
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Wei Tang; Yujie Zhang; Chaoxu Qian; Zhilan Yuan; Jun Du
Tags: apoptosis, caspase-3, fibroblasts, tenon's capsule, caspase-8
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4874-4880. doi:https://doi.org/10.1167/iovs.11-8968
Association of Genetic Variants in the TMCO1 Gene with Clinical Parameters Related to Glaucoma and Characterization of the Protein in the Eye Free
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Shiwani Sharma; Kathryn P. Burdon; Glyn Chidlow; Sonja Klebe; April Crawford; David P. Dimasi; Alpana Dave; Sarah Martin; Shahrbanou Javadiyan; John P. M. Wood; Robert Casson; Patrick Danoy; Kim Griggs; Alex W. Hewitt; John Landers; Paul Mitchell; David A. Mackey; Jamie E. Craig
Tags: eye, genes, genetics, glaucoma, proteins
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4917-4925. doi:https://doi.org/10.1167/iovs.11-9047
Connective Tissue Growth Factor–Mediated Upregulation of Neuromedin U Expression in Trabecular Meshwork Cells and its Role in Homeostasis of Aqueous Humor Outflow Free
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Padma Iyer; Rupalatha Maddala; Padmanabhan P. Pattabiraman; Ponugoti Vasantha Rao
Tags: connective tissue growth factor, aqueous humor, actins, proteins
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4952-4962. doi:https://doi.org/10.1167/iovs.12-9681
Structure-Function Relationship of the Macular Visual Field Sensitivity and the Ganglion Cell Complex Thickness in Glaucoma Free
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Jung Hwa Na; Michael S. Kook; Youngrok Lee; Seunghee Baek
Tags: ganglia, glaucoma, visual fields, optic disk
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 5044-5051. doi:https://doi.org/10.1167/iovs.11-9401

Immunology and Microbiology

Characterization of Fusarium Keratitis Outbreak Isolates: Contribution of Biofilms to Antimicrobial Resistance and Pathogenesis Free
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Pranab K. Mukherjee; Jyotsna Chandra; Changping Yu; Yan Sun; Eric Pearlman; Mahmoud A. Ghannoum
Tags: biofilms, disease outbreaks, fusarium, keratitis, pathogenesis
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4450-4457. doi:https://doi.org/10.1167/iovs.12-9848
Decreased IL-27 Expression in Association with an Increased Th17 Response in Vogt-Koyanagi-Harada Disease Free
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Chaokui Wang; Yuan Tian; Bo Lei; Xiang Xiao; Zi Ye; Fuzhen Li; Aize Kijlstra; Peizeng Yang
Tags: interleukin-27, uveomeningoencephalitic syndrome, interleukin-17, enzyme-linked immunosorbent assay
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4668-4675. doi:https://doi.org/10.1167/iovs.12-9863
Virological Analysis in Patients with Human Herpes Virus 6–Associated Ocular Inflammatory Disorders Free
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Sunao Sugita; Norio Shimizu; Ken Watanabe; Manabu Ogawa; Kazuichi Maruyama; Norio Usui; Manabu Mochizuki
Tags: dna, eye, hhv-6, inflammatory disorders, polymerase chain reaction
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4692-4698. doi:https://doi.org/10.1167/iovs.12-10095
Efficacy of Intravitreal Administrations of Linezolid in an Experimental Model of S. aureus –Related Endophthalmitis Free
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Maher Saleh; Sophie Lefèvre; Niyazi Acar; Tristan Bourcier; Luc Marcellin; Gilles Prévost; Audrey Subilia; David Gaucher; François Jehl
Tags: endophthalmitis, linezolid, eye, intravitreal injections, vitreous body
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4832-4841. doi:https://doi.org/10.1167/iovs.11-8417

Low Vision

The Prevalence and Causes of Visual Impairment in an Elderly Chinese Bai Ethnic Rural Population: The Yunnan Minority Eye Study Free
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Jun Li; Hua Zhong; Ning Cai; Tinghao Luo; Juanjuan Li; Xiaodan Su; Xun Li; Xuan Qiu; Yongming Yang; Yuansheng Yuan; Minbin Yu
Tags: chinese (other dialects), chinese people, eye, older adult, prevalence
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4498-4504. doi:https://doi.org/10.1167/iovs.12-9429
National Eye Institute Visual Function Questionnaire or Indian Vision Function Questionnaire for Visually Impaired: A Conundrum Free
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Vijaya K. Gothwal; Shailaja P. Reddy; Rebecca Sumalini; Seelam Bharani; Deepak K. Bagga
Tags: eye, questionnaires, rasch model, vision, precision
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4730-4738. doi:https://doi.org/10.1167/iovs.11-8776

Multidisciplinary Ophthalmic Imaging

Patterns of Ganglion Cell Complex and Nerve Fiber Layer Loss in Nonarteritic Ischemic Optic Neuropathy by Fourier-Domain Optical Coherence Tomography Free
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Divya Aggarwal; Ou Tan; David Huang; Alfredo A. Sadun
Tags: ganglia, nerve fibers, nonarteritic anterior ischemic optic neuropathy, non-arteritic ischemic optic neuropathy, optical coherence tomography
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4539-4545. doi:https://doi.org/10.1167/iovs.11-9300
Spatial Correlation between Hyperpigmentary Changes on Color Fundus Photography and Hyperreflective Foci on SDOCT in Intermediate AMD Free
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Francisco A. Folgar; Jessica H. Chow; Sina Farsiu; Wai T. Wong; Stefanie G. Schuman; Rachelle V. O'Connell; Katrina P. Winter; Emily Y. Chew; Thomas S. Hwang; Sunil K. Srivastava; Molly W. Harrington; Traci E. Clemons; Cynthia A. Toth
Tags: color, drusen, eye, fundus photography, hyperpigmentation
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4626-4633. doi:https://doi.org/10.1167/iovs.12-9813
Does Optic Nerve Head Size Variation Affect Circumpapillary Retinal Nerve Fiber Layer Thickness Measurement by Optical Coherence Tomography? Free
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David Huang; Vikas Chopra; Ake Tzu-Hui Lu; Ou Tan; Brian Francis; Rohit Varma; Advanced Imaging for Glaucoma Study (AIGS) Group
Tags: magnification, optic disk, retinal nerve fiber layer, optical coherence tomography
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4990-4997. doi:https://doi.org/10.1167/iovs.11-8214

Nantotechnology and Regenerative Medicine

Cell Therapy Modulates Expression of Tax1-Binding Protein 1 and Synaptotagmin IV in a Model of Optic Nerve Lesion Free
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Louise A. Mesentier-Louro; Juliana Coronel; Camila Zaverucha-do-Valle; Andre Mencalha; Bruno D. Paredes; Eliana Abdelhay; Rosalia Mendez-Otero; Marcelo F. Santiago
Tags: cell therapy, optic nerve, proteins, retina, gene expression
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4720-4729. doi:https://doi.org/10.1167/iovs.11-8198

Physiology and Pharmacology

Comparison of Choroidal and Optic Nerve Head Blood Flow Regulation during Changes in Ocular Perfusion Pressure Free
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Doreen Schmidl; Agnes Boltz; Semira Kaya; Rene Werkmeister; Nikolaus Dragostinoff; Michael Lasta; Elzbieta Polska; Gerhard Garhöfer; Leopold Schmetterer
Tags: exercise, isometric, fluid flow, intraocular pressure, optic disk, perfusion
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4337-4346. doi:https://doi.org/10.1167/iovs.11-9055
Effects of Palmitoylethanolamide on Aqueous Humor Outflow Free
PDF
Akhilesh Kumar; Zhuanhong Qiao; Pritesh Kumar; Zhao-Hui Song
Tags: adenoviruses, antagonists, aqueous humor, mitogen-activated protein kinases, phosphorylation
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4416-4425. doi:https://doi.org/10.1167/iovs.11-9294
Targeted Administration into the Suprachoroidal Space Using a Microneedle for Drug Delivery to the Posterior Segment of the Eye Free
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Samirkumar R. Patel; Damian E. Berezovsky; Bernard E. McCarey; Vladimir Zarnitsyn; Henry F. Edelhauser; Mark R. Prausnitz
Tags: drug delivery systems, drug delivery, targeted, eye, oryctolagus cuniculus, fluorescence
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4433-4441. doi:https://doi.org/10.1167/iovs.12-9872
Methylene Blue Protects Primary Rat Retinal Ganglion Cells from Cellular Senescence Free
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Donald R. Daudt, III; Brett Mueller; Yong H. Park; Yi Wen; Thomas Yorio
Tags: cell survival, cellular senescence, cytochrome c oxidase, ethidium, hypoxia
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4657-4667. doi:https://doi.org/10.1167/iovs.12-9734
Retinal Vein Pulsation Is in Phase with Intracranial Pressure and Not Intraocular Pressure Free
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William H. Morgan; Christopher R. P. Lind; Samuel Kain; Naeem Fatehee; Arul Bala; Dao-Yi Yu
Tags: central retinal vein, intracranial pressure, intraocular pressure, cardiac cycle
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4676-4681. doi:https://doi.org/10.1167/iovs.12-9837
Neuroprotective Effects of Nonfeminizing Estrogens in Retinal Photoreceptor Neurons Free
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Everett Nixon; James W. Simpkins
Tags: cell survival, estrogen, glutamate, glutamates, neurons
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4739-4747. doi:https://doi.org/10.1167/iovs.12-9517
β-LGND2, an ERβ Selective Agonist, Inhibits Pathologic Retinal Neovascularization Free
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Anand Giddabasappa; Jeetendra R. Eswaraka; Christina M. Barrett; Matthew N. Bauler; Zhongzhi Wu; Muralimohan Yepuru; Duane D. Miller; James T. Dalton
Tags: agonists, angiogenesis, hypoxia, mice, neovascularization, pathologic
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 5066-5075. doi:https://doi.org/10.1167/iovs.12-9627
The Effective Add Inherent in 2-Zone Negative Lenses Inhibits Eye Growth in Myopic Young Chicks Free
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Yue Liu; Christine Wildsoet
Tags: eye, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 5085-5093. doi:https://doi.org/10.1167/iovs.12-9628

Retina

Layer-Specific Manganese-Enhanced MRI of the Retina in Light and Dark Adaptation Free
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Bryan H. De La Garza; Guang Li; Yen-Yu I. Shih; Timothy Q. Duong
Tags: dark adaptation, magnetic resonance imaging, manganese, retina, eye
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4352-4358. doi:https://doi.org/10.1167/iovs.11-8826
A Phage Display-Based Approach to Investigate Abnormal Neovessels of the Retina Free
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Magdalena Staniszewska; Xiaolin Gu; Carmelo Romano; Andrius Kazlauskas
Tags: bacteriophages, retina, peptides
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4371-4379. doi:https://doi.org/10.1167/iovs.12-9690
Correlation between Photoreceptor Layer Integrity and Visual Function in Patients with Stargardt Disease: Implications for Gene Therapy Free
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Francesco Testa; Settimio Rossi; Andrea Sodi; Ilaria Passerini; Valentina Di Iorio; Michele Della Corte; Sandro Banfi; Enrico Maria Surace; Ugo Menchini; Alberto Auricchio; Francesca Simonelli
Tags: electroretinography, gene therapy, personal integrity, photoreceptors, stargardt's disease
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4409-4415. doi:https://doi.org/10.1167/iovs.11-8201
Quantitative Evaluation of Papilledema from Stereoscopic Color Fundus Photographs Free
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Li Tang; Randy H. Kardon; Jui-Kai Wang; Mona K. Garvin; Kyungmoo Lee; Michael D. Abràmoff
Tags: color, fundus photography, optic disk, papilledema, volume
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4490-4497. doi:https://doi.org/10.1167/iovs.12-9803
Quantitative Analyses of High-Resolution 3D MR Images of Highly Myopic Eyes to Determine Their Shapes Free
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Muka Moriyama; Kyoko Ohno-Matsui; Toshio Modegi; Junichi Kondo; Yoichi Takahashi; Makoto Tomita; Takashi Tokoro; Ikuo Morita
Tags: eye, software
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4510-4518. doi:https://doi.org/10.1167/iovs.12-9426
Oxidative and Endoplasmic Reticulum Stresses Mediate Apoptosis Induced by Modified LDL in Human Retinal Müller Cells Free
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Mingyuan Wu; Shihe Yang; Michael H. Elliott; Dongxu Fu; Kenneth Wilson; Jing Zhang; Mei Du; Junping Chen; Timothy Lyons
Tags: apoptosis, low-density lipoproteins, suidae, stress, cell death
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4595-4604. doi:https://doi.org/10.1167/iovs.12-9910
Long-Term Characterization of Retinal Degeneration in rd1 and rd10 Mice Using Spectral Domain Optical Coherence Tomography Free
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Mark E. Pennesi; Keith V. Michaels; Sienna S. Magee; Anastasiya Maricle; Sean P. Davin; Anupam K. Garg; Michael J. Gale; Daniel C. Tu; Yuquan Wen; Laura R. Erker; Peter J. Francis
Tags: diagnostic imaging, mice, optical coherence tomography, retinal degeneration, retina
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4644-4656. doi:https://doi.org/10.1167/iovs.12-9611
Double Concentric Autofluorescence Ring in NR2E3-p.G56R-Linked Autosomal Dominant Retinitis Pigmentosa Free
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Pascal Escher; Hoai V. Tran; Veronika Vaclavik; Francois X. Borruat; Daniel F. Schorderet; Francis L. Munier
Tags: autofluorescence, family, retinitis pigmentosa, eye, pigment
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4754-4764. doi:https://doi.org/10.1167/iovs.11-8693
Progressive Retinal Degeneration in Transgenic Mice with Overexpression of Endothelin-1 in Vascular Endothelial Cells Free
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Xue-Song Mi; Xu Zhang; Qian Feng; Amy Cheuk Yin Lo; Sookja Kim Chung; Kwok-Fai So
Tags: endothelin-1, mice, retina, retinal degeneration, protein overexpression
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4842-4851. doi:https://doi.org/10.1167/iovs.12-9999
Profiles of Macular Pigment Optical Density and Their Changes Following Supplemental Lutein and Zeaxanthin: New Results from the LUNA Study Free
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Meike Zeimer; Martha Dietzel; Hans Werner Hense; Britta Heimes; Ulrike Austermann; Daniel Pauleikhoff
Tags: eye, laparoscopic uterosacral nerve ablation, lutein, optics, pigment
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4852-4859. doi:https://doi.org/10.1167/iovs.12-9713
Proliferative Vitreoretinopathy in the Swine–A New Model Free
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Kazuhiko Umazume; Yoreh Barak; Kevin McDonald; LanHsin Liu; Henry J. Kaplan; Shigeo Tamiya
Tags: epiretinal membrane, eye, retinal pigment cell, suidae, vitreoretinopathy, proliferative
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4910-4916. doi:https://doi.org/10.1167/iovs.12-9768
The 1D4 Antibody Labels Outer Segments of Long Double Cone But Not Rod Photoreceptors in Zebrafish Free
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Jun Yin; Jan Brocher; Bastian Linder; Anja Hirmer; Husvinee Sundaramurthi; Utz Fischer; Christoph Winkler
Tags: antibodies, retinal cone, rod photoreceptors, zebrafish, animals, transgenic
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4943-4951. doi:https://doi.org/10.1167/iovs.12-9511

Retinal Cell Biology

Sleeping Beauty Transposon-Mediated Transfection of Retinal and Iris Pigment Epithelial Cells Free
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Sandra Johnen; Zsuzsanna Izsvák; Michael Stöcker; Nina Harmening; Anna Katharina Salz; Peter Walter; Gabriele Thumann
Tags: dna transposons, immune reconstitution inflammatory syndrome, interprofessional education, pigment, sleep
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4787-4796. doi:https://doi.org/10.1167/iovs.12-9951
Mitochondria DNA Replication and DNA Methylation in the Metabolic Memory Associated with Continued Progression of Diabetic Retinopathy Free
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Shikha Tewari; Qing Zhong; Julia M Santos; Renu A Kowluru
Tags: diabetic retinopathy, dna methylation, dna, mitochondrial, memory, polymerase chain reaction
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4881-4888. doi:https://doi.org/10.1167/iovs.12-9732
Mitochondrial Inhibition in Rat Retinal Cell Cultures as a Model of Metabolic Compromise: Mechanisms of Injury and Neuroprotection Free
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John P. M. Wood; Teresa Mammone; Glyn Chidlow; Tim Greenwell; Robert J. Casson
Tags: cell culture techniques, mass or substance concentration per volume, mechanism of injury, mitochondria, neuroglia
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4897-4909. doi:https://doi.org/10.1167/iovs.11-9171
Effects of Proinflammatory Cytokines on the Claudin-19 Rich Tight Junctions of Human Retinal Pigment Epithelium Free
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Shaomin Peng; Geliang Gan; Veena S. Rao; Ron A. Adelman; Lawrence J. Rizzolo
Tags: cytokine, tight junctions, retinal pigment epithelium, culture media
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 5016-5028. doi:https://doi.org/10.1167/iovs.11-8311

Translational

Refractive Lenticule Re-Implantation after Myopic ReLEx: A Feasibility Study of Stromal Restoration after Refractive Surgery in a Rabbit Model Free
PDF
Romesh I. Angunawela; Andri K. Riau; Shyam S. Chaurasia; Donald T. Tan; Jodhbir S. Mehta
Tags: cornea, oryctolagus cuniculus, surgical ocular refractive procedure, surgical replantation, feasibility studies
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4975-4985. doi:https://doi.org/10.1167/iovs.12-10170

Visual Neuroscience

Circadian and Wake-Dependent Effects on the Pupil Light Reflex in Response to Narrow-Bandwidth Light Pulses Free
PDF
Mirjam Münch; Lorette Léon; Sylvain V. Crippa; Aki Kawasaki
Tags: blue light, drowsiness, melanopsin, melatonin, pupil
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4546-4555. doi:https://doi.org/10.1167/iovs.12-9494

Visual Psychophysics and Physiological Optics

Visual Performance with Wave Aberration Correction after Penetrating, Deep Anterior Lamellar, or Endothelial Keratoplasty Free
PDF
Seth M. Pantanelli; Ramkumar Sabesan; Steven S. T. Ching; Geunyoung Yoon; Holly B. Hindman
Tags: contrast sensitivity, descemet stripping endothelial keratoplasty, endothelium, keratoplasty, optics
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4797-4804. doi:https://doi.org/10.1167/iovs.12-10003

Clinical Trials

Evaluations of Tear Protein Markers in Dry Eye Disease: Repeatability of Measurement and Correlation with Disease Free
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Jing-Feng Huang; Yi Zhang; Kay D. Rittenhouse; Eve H. Pickering; Michael T. McDowell
Tags: dry eye syndromes, proteins, interleukin-8, eye
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4556-4564. doi:https://doi.org/10.1167/iovs.11-9054

Letters to the Editor

Is Drusen Area Really So Important? Free
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Gui-shuang Ying
Tags: drusen
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4407-4408. doi:https://doi.org/10.1167/iovs.12-10032
Accuracy, Validity, and Reliability of the Infrared Optical Head Tracker (IOHT) Free
PDF
Siamak Sabour; Fariba Ghassemi
Tags: optics, reliability, validity of results
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4776. doi:https://doi.org/10.1167/iovs.12-10324
An Analysis of the Use of Multiple Comparison Corrections in Ophthalmology Research Free
PDF
Carrie Huisingh; Gerald McGwin, Jr
Tags: ophthalmology
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4777. doi:https://doi.org/10.1167/iovs.12-10336
Author Response: The Association between Glaucoma Prevalence and Supplementation with the Oxidants Calcium and Iron Free
PDF
Kuldev Singh; Sophia Y. Wang; Shan C. Lin
Tags: calcium, glaucoma, iron, oxidants, prevalence
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4940. doi:https://doi.org/10.1167/iovs.12-10433
The Association between Glaucoma Prevalence and Supplementation with the Oxidants Calcium and Iron Free
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Yahya Shaikh; Fei Yu; Anne L. Coleman
Tags: calcium, glaucoma, iron, oxidants, prevalence
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4941-4942. doi:https://doi.org/10.1167/iovs.12-10315

Erratum

Erratum Free
PDF
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 5076. doi:https://doi.org/10.1167/iovs.11-8114a
Erratum Free
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Investigative Ophthalmology & Visual Science July 2012, Vol.53, 5094. doi:https://doi.org/10.1167/iovs.11-9110a
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