Select a back issue
Select a back issue
  • Alerts
    User Alerts
    You are adding an alert for:
    Investigative Ophthalmology & Visual Science
    You will receive an email whenever new content is published in the Investigative Ophthalmology & Visual Science. You can manage this and all other alerts in My Account
    The alert will be sent to:
    ×
    This feature is available to authenticated users only.
    Sign In or Create an Account ×

Research Highlight

Quantifying Structures in the Ocular Fundus Free
PDF
Douglas R. Anderson; Claude Burgoyne
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4531. doi:https://doi.org/10.1167/iovs.12-10253

Anatomy and Pathology/Oncology

JARID1B Protein Expression and Prognostic Implications in Uveal Melanoma Free
PDF
Patrik Radberger; Agatha Radberger; Vladimir J. N. Bykov; Stefan Seregard; Mario A. Economou
Tags: melanoma, neoplasms, proteins, uveal melanoma
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4442-4449. doi:https://doi.org/10.1167/iovs.11-9296
Impact of Repeated Topical-Loaded Manganese-Enhanced MRI on the Mouse Visual System Free
PDF
Shu-Wei Sun; Tiffany Thiel; Hsiao-Fang Liang
Tags: magnetic resonance imaging, manganese, mice, optic nerve, visual system
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4699-4709. doi:https://doi.org/10.1167/iovs.12-9715

Biochemistry and Molecular Biology

Ceramide Kinase-Like (CERKL) Interacts with Neuronal Calcium Sensor Proteins in the Retina in a Cation-Dependent Manner Free
PDF
Mariela J. Nevet; Sharon Vekslin; Alexander M. Dizhoor; Elena V. Olshevskaya; Rotem Tidhar; Anthony H. Futerman; Tamar Ben-Yosef
Tags: calcium, cations, ceramides, phosphotransferases, proteins
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4565-4574. doi:https://doi.org/10.1167/iovs.12-9770
Leber's Hereditary Optic Neuropathy Is Associated with the T3866C Mutation in Mitochondrial ND1 Gene in Three Han Chinese Families Free
PDF
Xiangtian Zhou; Yaping Qian; Juanjuan Zhang; Yi Tong; Pingping Jiang; Min Liang; Xianning Dai; Huihui Zhou; Fuxin Zhao; Yanchun Ji; Jun Qin Mo; Jia Qu; Min-Xin Guan
Tags: cell lines, chinese (other dialects), chinese people, dna, mitochondrial, family
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4586-4594. doi:https://doi.org/10.1167/iovs.11-9109
Surface Chemistry Study of the Interactions of Pharmaceutical Ingredients with Human Meibum Films Free
PDF
Georgi A. Georgiev; Norihiko Yokoi; Slavyana Ivanova; Rumen Krastev; Zdravko Lalchev
Tags: bacterial artificial chromosomes, blood alcohol concentration, bronchioloalveolar carcinoma, compression, eyedrops
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4605-4615. doi:https://doi.org/10.1167/iovs.12-9907
Differential Expression of Fourteen Proteins between Uveal Melanoma from Patients Who Subsequently Developed Distant Metastases versus Those Who Did Not Free
PDF
Annett Linge; Susan Kennedy; Deirdre O'Flynn; Stephen Beatty; Paul Moriarty; Michael Henry; Martin Clynes; Annemarie Larkin; Paula Meleady
Tags: proteins, uveal melanoma, fatty acid binding protein 3, neoplasm metastasis, metastasis, distant
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4634-4643. doi:https://doi.org/10.1167/iovs.11-9019
Species Variation in Small Molecule Components of Animal Vitreous Free
PDF
Jenifer Mains; Lay Ean Tan; Tong Zhang; Louise Young; Ruiwen Shi; Clive Wilson
Tags: small molecule, vitreous body, acetylcholinesterase, oryctolagus cuniculus, body tissue
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4778-4786. doi:https://doi.org/10.1167/iovs.12-9998
Pattern of Expression of p53, Its Family Members, and Regulators during Early Ocular Development and in the Post-Mitotic Retina Free
PDF
Linda Vuong; Daniel E. Brobst; Anisse Saadi; Ivana Ivanovic; Muayyad R. Al-Ubaidi
Tags: eye development, family, proteins, retina, polymerase chain reaction
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4821-4831. doi:https://doi.org/10.1167/iovs.11-8681

Clinical and Epidemiologic Research

A New Epidemiological Aid in Deciding Whether to Continue or Stop a Treatment Free
PDF
Mari Elshout; Margriet I. van der Reis; Carroll A. B. Webers; Ellen C. La Heij; Fred Hendrikse; Jan S. A. G. Schouten
Tags: visual acuity, follow-up, intraocular pressure, convergence insufficiency, weight measurement scales
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4331-4336. doi:https://doi.org/10.1167/iovs.11-9242
The Association between Time Spent Outdoors and Myopia Using a Novel Biomarker of Outdoor Light Exposure Free
PDF
Justin C. Sherwin; Alex W. Hewitt; Minas T. Coroneo; Lisa S. Kearns; Lyn R. Griffiths; David A. Mackey
Tags: biological markers, conjunctiva, myopia, autofluorescence, light exposure
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4363-4370. doi:https://doi.org/10.1167/iovs.11-8677
Prevalence and Associated Risk Factors of Myopic Maculopathy in Elderly Chinese: The Shihpai Eye Study Free
PDF
Shih-Jen Chen; Ching-Yu Cheng; An-Fei Li; Kai-Ling Peng; Pesus Chou; Shih-Hwa Chiou; Wen-Ming Hsu
Tags: chinese people, eye, macular disorders, older adult, prevalence
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4868-4873. doi:https://doi.org/10.1167/iovs.12-9919
Topography of Geographic Atrophy in Age-Related Macular Degeneration Free
PDF
Matthias M. Mauschitz; Sofia Fonseca; Petrus Chang; Arno P. Göbel; Monika Fleckenstein; Glenn J. Jaffe; Frank G. Holz; Steffen Schmitz-Valckenberg; for the GAP Study Group
Tags: atrophy, age-related macular degeneration
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4932-4939. doi:https://doi.org/10.1167/iovs.12-9711
The Heritability of Macular Response to Supplemental Lutein and Zeaxanthin: A Classic Twin Study Free
PDF
Christopher J. Hammond; S. H. Melissa Liew; Frederik J. Van Kuijk; Stephen Beatty; John M. Nolan; Tim D. Spector; Clare E. Gilbert
Tags: carotenoids, lutein, twin studies, twins, diet
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4963-4968. doi:https://doi.org/10.1167/iovs.12-9618
Devising Two-Stage and Multistage Phase II Studies on Systemic Adjuvant Therapy for Uveal Melanoma Free
PDF
John Whitehead; Svetlana Tishkovskaya; Jemma O'Connor; Bertil Damato
Tags: adjuvant therapy, phase 2 clinical trials, sample size, uveal melanoma, research design
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4986-4989. doi:https://doi.org/10.1167/iovs.12-9858
Myopia Control with Orthokeratology Contact Lenses in Spain: Refractive and Biometric Changes Free
PDF
Jacinto Santodomingo-Rubido; César Villa-Collar; Bernard Gilmartin; Ramón Gutiérrez-Ortega
Tags: biometry, myopia, orthokeratology, orthokeratology contact lenses, spain
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 5060-5065. doi:https://doi.org/10.1167/iovs.11-8005

Cornea

Anti-Inflammatory Effects of Alpha Linolenic Acid on Human Corneal Epithelial Cells Free
PDF
Nir Erdinest; Or Shmueli; Yoni Grossman; Haim Ovadia; Abraham Solomon
Tags: alpha-linolenic acid, anti-inflammatory agents, corneal epithelial cells, cytokine, interleukin-6
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4396-4406. doi:https://doi.org/10.1167/iovs.12-9724
Changes in Diadenosine Polyphosphates during Alignment-Fit and Orthokeratology Rigid Gas Permeable Lens Wear Free
PDF
Gonzalo Carracedo; José Manuel González-Méijome; Jesús Pintor
Tags: lens (device), lens, crystalline, muscle rigidity, orthokeratology, polyphosphates
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4426-4432. doi:https://doi.org/10.1167/iovs.11-9342
Semaphorin 7a Links Nerve Regeneration and Inflammation in the Cornea Free
PDF
Abed Namavari; Shweta Chaudhary; Okan Ozturk; Jin-Hong Chang; Lisette Yco; Snehal Sonawane; Neelima Katam; Vishakha Khanolkar; Joelle Hallak; Joy Sarkar; Sandeep Jain
Tags: cornea, nerve regeneration, semaphorins, inflammation
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4575-4585. doi:https://doi.org/10.1167/iovs.12-9760
Analysis of Comparison of Human Meibomian Lipid Films and Mixtures with Cholesteryl Esters In Vitro Films using High Resolution Color Microscopy Free
PDF
Thomas J. Millar; P. Ewen King-Smith
Tags: cholesterol esters, color, lipids
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4710-4719. doi:https://doi.org/10.1167/iovs.12-10022
uPA Binding to PAI-1 Induces Corneal Myofibroblast Differentiation on Vitronectin Free
PDF
Lingyan Wang; Christine M. Ly; Chun-Ying Ko; Erin E. Meyers; Daniel A. Lawrence; Audrey M. Bernstein
Tags: plasminogen activator inhibitor 1, urokinase, vitronectin, cornea, integrins
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4765-4775. doi:https://doi.org/10.1167/iovs.12-10042
Anterior Chamber Dimensions and Posterior Corneal Arc Length in Malay Eyes: An Anterior Segment Optical Coherence Tomography Study Free
PDF
Deborah K. L. Tan; Wesley Chong; Wan Ting Tay; Leonard H. Yuen; Mingguang He; Tin Aung; Donald T. H. Tan; Tien Yin Wong; Jodhbir S. Mehta
Tags: anterior chamber of eye, cornea, eye, optical coherence tomography
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4860-4867. doi:https://doi.org/10.1167/iovs.12-9787
The Relationship between Subbasal Nerve Morphology and Corneal Sensation in Ocular Surface Disease Free
PDF
Antoine Labbé; Haiyan Alalwani; Charles Van Went; Emmanuelle Brasnu; Dan Georgescu; Christophe Baudouin
Tags: cornea, language morphology, morphology, neurons, sensory perception
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4926-4931. doi:https://doi.org/10.1167/iovs.11-8708
Abnormalities of Stromal Structure in the Bullous Keratopathy Cornea Identified by Second Harmonic Generation Imaging Microscopy Free
PDF
Naoyuki Morishige; Norihiro Yamada; Xu Zhang; Yukiko Morita; Naoyuki Yamada; Kazuhiro Kimura; Atsushi Takahara; Koh-Hei Sonoda
Tags: bullous keratopathy, cornea, diagnostic imaging, edema, harmonics
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4998-5003. doi:https://doi.org/10.1167/iovs.12-10214
Corneal Biomechanical Properties from Two-Dimensional Corneal Flap Extensiometry: Application to UV-Riboflavin Cross-Linking Free
PDF
Sabine Kling; Harilaos Ginis; Susana Marcos
Tags: cornea, corneal collagen cross-linking, riboflavin, surgical flaps, 5-lipoxygenase-activating protein
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 5010-5015. doi:https://doi.org/10.1167/iovs.12-9583
SERPINA3K Protects against Oxidative Stress via Modulating ROS Generation/Degradation and KEAP1-NRF2 Pathway in the Corneal Epithelium Free
PDF
Tong Zhou; Rongrong Zong; Zhoujing Zhang; Chengpeng Zhu; Fangyu Pan; Xinye Xiao; Zhen Liu; Hui He; Jian-xing Ma; Zuguo Liu; Yueping Zhou
Tags: antioxidants, catabolism, corneal epithelium, oxidative stress, western blotting
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 5033-5043. doi:https://doi.org/10.1167/iovs.12-9729
iTRAQ Quantitative Proteomics in the Analysis of Tears in Dry Eye Patients Free
PDF
Sruthi Srinivasan; Mirunalni Thangavelu; Liwen Zhang; Kari B. Green; Kelly K. Nichols
Tags: dry eye syndromes, proteins, proteomics, muramidase
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 5052-5059. doi:https://doi.org/10.1167/iovs.11-9022
Changes in Mouse Corneal Epithelial Innervation with Age Free
PDF
Cun Wang; Ting Fu; Chaoyong Xia; Zhijie Li
Tags: cornea, epithelium, mice, nerve fibers, nerve supply
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 5077-5084. doi:https://doi.org/10.1167/iovs.12-9704

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Effects of Induced Monocular Blur versus Anisometropic Amblyopia on Saccades, Reaching, and Eye-Hand Coordination Free
PDF
Ewa Niechwiej-Szwedo; Sean A. Kennedy; Linda Colpa; Manokaraananthan Chandrakumar; Herbert C. Goltz; Agnes M. F. Wong
Tags: amblyopia, anisometropic amblyopia, eye-hand coordination, saccades, eye
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4354-4362. doi:https://doi.org/10.1167/iovs.12-9855
Three-Dimensional Display-Induced Transient Myopia and the Difference in Myopic Shift between Crossed and Uncrossed Disparities Free
PDF
Young-Woo Suh; Jaeryung Oh; Hyo-Myung Kim; Yoonae A Cho; Jong-Suk Song
Tags: myopia transient, uncrossed disparity, myopia, refractive errors, crossed disparity
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 5029-5032. doi:https://doi.org/10.1167/iovs.12-9588

Genetics

Retinal Phenotypes in Patients Homozygous for the G1961E Mutation in the ABCA4 Gene Free
PDF
Tomas R. Burke; Gerald A. Fishman; Jana Zernant; Carl Schubert; Stephen H. Tsang; R. Theodore Smith; Radha Ayyagari; Robert K. Koenekoop; Allison Umfress; Maria Laura Ciccarelli; Alfonso Baldi; Alessandro Iannaccone; Frans P. M. Cremers; Caroline C. W. Klaver; Rando Allikmets
Tags: genes, homozygote, mutation, phenotype
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4458-4467. doi:https://doi.org/10.1167/iovs.11-9166
Genome-Wide Analysis of Central Corneal Thickness in Primary Open-Angle Glaucoma Cases in the NEIGHBOR and GLAUGEN Consortia Free
PDF
Megan Ulmer; Jun Li; Brian L. Yaspan; Ayse Bilge Ozel; Julia E. Richards; Sayoko E. Moroi; Felicia Hawthorne; Donald L. Budenz; David S. Friedman; Douglas Gaasterland; Jonathan Haines; Jae H. Kang; Richard Lee; Paul Lichter; Yutao Liu; Louis R. Pasquale; Margaret Pericak-Vance; Anthony Realini; Joel S. Schuman; Kuldev Singh; Douglas Vollrath; Robert Weinreb; Gadi Wollstein; Donald J. Zack; Kang Zhang; Terri Young; R. Rand Allingham; Janey L. Wiggs; Allison Ashley-Koch; Michael A. Hauser
Tags: cornea, genome-wide association study, open-angle glaucoma
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4468-4474. doi:https://doi.org/10.1167/iovs.12-9784
A Novel GUCY2D Mutation, V933A, Causes Central Areolar Choroidal Dystrophy Free
PDF
Anne E. Hughes; Weihua Meng; Andrew J. Lotery; Declan T. Bradley
Tags: mutation, family
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4748-4753. doi:https://doi.org/10.1167/iovs.12-10061
A Genotype-Phenotype Comparison of ADAMTSL4 and FBN1 in Isolated Ectopia Lentis Free
PDF
Aman Chandra; Jose A. Aragon-Martin; Kathryn Hughes; Sabiha Gati; M. Ashwin Reddy; Charu Deshpande; Graham Cormack; Anne H. Child; David G. Charteris; Gavin Arno
Tags: ectopia lentis, genotype, mutation, phenotype, cornea
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4889-4896. doi:https://doi.org/10.1167/iovs.12-9874
Association of C2 and CFB Polymorphisms with Anterior Uveitis Free
PDF
Ming-ming Yang; Timothy Y. Y. Lai; Pancy O. S. Tam; Sylvia W. Y. Chiang; Tsz Kin Ng; Ke Liu; Chi Pui Pang
Tags: polymorphism, single nucleotide polymorphism, uveitis, anterior, hla-b27 antigen, haplotypes
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4969-4974. doi:https://doi.org/10.1167/iovs.12-9478
Genetic Factors for Choroidal Neovascularization Associated with High Myopia Free
PDF
Nicolas Leveziel; Yi Yu; Robyn Reynolds; Albert Tai; Weihua Meng; Violaine Caillaux; Patrick Calvas; Bernard Rosner; François Malecaze; Eric H. Souied; Johanna M. Seddon
Tags: choroidal neovascularization, genetic aspects, myopia, single nucleotide polymorphism
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 5004-5009. doi:https://doi.org/10.1167/iovs.12-9538

Glaucoma

Detection of Localized Retinal Nerve Fiber Layer Defects with Posterior Pole Asymmetry Analysis of Spectral Domain Optical Coherence Tomography Free
PDF
Je Hyun Seo; Tae-Woo Kim; Robert N. Weinreb; Ki Ho Park; Seok Hwan Kim; Dong Myung Kim
Tags: glaucoma, optical coherence tomography, retinal nerve fiber layer, sensitivity and specificity, photography
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4347-4353. doi:https://doi.org/10.1167/iovs.12-9673
Thickness, Phase Retardation, Birefringence, and Reflectance of the Retinal Nerve Fiber Layer in Normal and Glaucomatous Non-Human Primates Free
PDF
Jordan Dwelle; Shuang Liu; Bingqing Wang; Austin McElroy; Derek Ho; Mia K. Markey; Thomas Milner; H. Grady Rylander, III
Tags: birefringence, glaucoma, primates, retinal nerve fiber layer, eye
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4380-4395. doi:https://doi.org/10.1167/iovs.11-9130
The Effects of Peripapillary Atrophy on the Diagnostic Ability of Stratus and Cirrus OCT in the Analysis of Optic Nerve Head Parameters and Disc Size Free
PDF
Sun Young Kim; Hae-Young L. Park; Chan Kee Park
Tags: atrophy, glaucoma, optic disk, retinal nerve fiber layer, eye
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4475-4484. doi:https://doi.org/10.1167/iovs.12-9682
Glaucoma Progression in Eyes with a History of Refractive Corneal Surgery Free
PDF
Yoon Jeon Kim; Sung-Cheol Yun; Jung Hwa Na; Hung Won Tchah; Jong Jin Jung; Kyung Rim Sung
Tags: eye, glaucoma, medical history, operative procedure on cornea, surgical ocular refractive procedure
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4485-4489. doi:https://doi.org/10.1167/iovs.12-9862
Reproducibility of Macular, Retinal Nerve Fiber Layer, and ONH Measurements by OCT in Rhesus Monkeys: The Beijing Intracranial and Intraocular Pressure (iCOP) Study Free
PDF
Zheng Zhang; Diya Yang; Jinhong Sang; Ruowu Hou; Kegao Liu; Zhen Li; Xiaobin Xie; Jost B. Jonas; Ningli Wang
Tags: cercopithecidae, eye, intraocular pressure, macaca mulatta, optic disk
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4505-4509. doi:https://doi.org/10.1167/iovs.12-9439
Measurement of Optic Disc Size and Rim Area with Spectral-Domain OCT and Scanning Laser Ophthalmoscopy Free
PDF
Sasan Moghimi; Hamid Hosseini; Jay Riddle; Gina Yoo Lee; Elena Bitrian; JoAnn Giaconi; Joseph Caprioli; Kouros Nouri-Mahdavi
Tags: diagnostic imaging, eye, magnification, optic disk, scanning laser ophthalmoscopy
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4519-4530. doi:https://doi.org/10.1167/iovs.11-8362
Perturbation of Hyaluronan Synthesis in the Trabecular Meshwork and the Effects on Outflow Facility Free
PDF
Kate E. Keller; Ying Ying Sun; Yong-Feng Yang; John M. Bradley; Ted S. Acott
Tags: enzyme-linked immunosorbent assay, eye, genes, hyaluronan, lentivirus
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4616-4625. doi:https://doi.org/10.1167/iovs.12-9500
Rac1 Inhibition Prevents Tissue Contraction and MMP Mediated Matrix Remodeling in the Conjunctiva Free
PDF
Victoria E. Tovell; Chi Y. Chau; Peng T. Khaw; Maryse Bailly
Tags: body tissue, collagen, conjunctiva, gel, interstitial collagenase
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4682-4691. doi:https://doi.org/10.1167/iovs.11-8577
Wide 3-Dimensional Macular Ganglion Cell Complex Imaging with Spectral-Domain Optical Coherence Tomography in Glaucoma Free
PDF
Satoshi Morooka; Masanori Hangai; Masayuki Nukada; Noriko Nakano; Kohei Takayama; Yugo Kimura; Tadamichi Akagi; Hanako Ohashi Ikeda; Atsushi Nonaka; Nagahisa Yoshimura
Tags: diagnostic imaging, ganglia, glaucoma, optical coherence tomography, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4805-4812. doi:https://doi.org/10.1167/iovs.12-9870
Characteristics of Optic Disc Morphology in Glaucoma Patients with Parafoveal Scotoma Compared to Peripheral Scotoma Free
PDF
Kyoung In Jung; Hae-Young L. Park; Chan Kee Park
Tags: glaucoma, language morphology, morphology, optic disk, parafoveal region
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4813-4820. doi:https://doi.org/10.1167/iovs.12-9908
Induction and Mechanism of Apoptosis by Hydroxycamptothecin in Human Tenon's Capsule Fibroblasts Free
PDF
Wei Tang; Yujie Zhang; Chaoxu Qian; Zhilan Yuan; Jun Du
Tags: apoptosis, caspase-3, fibroblasts, tenon's capsule, caspase-8
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4874-4880. doi:https://doi.org/10.1167/iovs.11-8968
Association of Genetic Variants in the TMCO1 Gene with Clinical Parameters Related to Glaucoma and Characterization of the Protein in the Eye Free
PDF
Shiwani Sharma; Kathryn P. Burdon; Glyn Chidlow; Sonja Klebe; April Crawford; David P. Dimasi; Alpana Dave; Sarah Martin; Shahrbanou Javadiyan; John P. M. Wood; Robert Casson; Patrick Danoy; Kim Griggs; Alex W. Hewitt; John Landers; Paul Mitchell; David A. Mackey; Jamie E. Craig
Tags: eye, genes, genetics, glaucoma, proteins
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4917-4925. doi:https://doi.org/10.1167/iovs.11-9047
Connective Tissue Growth Factor–Mediated Upregulation of Neuromedin U Expression in Trabecular Meshwork Cells and its Role in Homeostasis of Aqueous Humor Outflow Free
PDF
Padma Iyer; Rupalatha Maddala; Padmanabhan P. Pattabiraman; Ponugoti Vasantha Rao
Tags: connective tissue growth factor, aqueous humor, actins, proteins
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4952-4962. doi:https://doi.org/10.1167/iovs.12-9681
Structure-Function Relationship of the Macular Visual Field Sensitivity and the Ganglion Cell Complex Thickness in Glaucoma Free
PDF
Jung Hwa Na; Michael S. Kook; Youngrok Lee; Seunghee Baek
Tags: ganglia, glaucoma, visual fields, optic disk
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 5044-5051. doi:https://doi.org/10.1167/iovs.11-9401

Immunology and Microbiology

Characterization of Fusarium Keratitis Outbreak Isolates: Contribution of Biofilms to Antimicrobial Resistance and Pathogenesis Free
PDF
Pranab K. Mukherjee; Jyotsna Chandra; Changping Yu; Yan Sun; Eric Pearlman; Mahmoud A. Ghannoum
Tags: biofilms, disease outbreaks, fusarium, keratitis, pathogenesis
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4450-4457. doi:https://doi.org/10.1167/iovs.12-9848
Decreased IL-27 Expression in Association with an Increased Th17 Response in Vogt-Koyanagi-Harada Disease Free
PDF
Chaokui Wang; Yuan Tian; Bo Lei; Xiang Xiao; Zi Ye; Fuzhen Li; Aize Kijlstra; Peizeng Yang
Tags: interleukin-27, uveomeningoencephalitic syndrome, interleukin-17, enzyme-linked immunosorbent assay
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4668-4675. doi:https://doi.org/10.1167/iovs.12-9863
Virological Analysis in Patients with Human Herpes Virus 6–Associated Ocular Inflammatory Disorders Free
PDF
Sunao Sugita; Norio Shimizu; Ken Watanabe; Manabu Ogawa; Kazuichi Maruyama; Norio Usui; Manabu Mochizuki
Tags: dna, eye, hhv-6, inflammatory disorders, polymerase chain reaction
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4692-4698. doi:https://doi.org/10.1167/iovs.12-10095
Efficacy of Intravitreal Administrations of Linezolid in an Experimental Model of S. aureus –Related Endophthalmitis Free
PDF
Maher Saleh; Sophie Lefèvre; Niyazi Acar; Tristan Bourcier; Luc Marcellin; Gilles Prévost; Audrey Subilia; David Gaucher; François Jehl
Tags: endophthalmitis, linezolid, eye, intravitreal injections, vitreous body
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4832-4841. doi:https://doi.org/10.1167/iovs.11-8417

Low Vision

The Prevalence and Causes of Visual Impairment in an Elderly Chinese Bai Ethnic Rural Population: The Yunnan Minority Eye Study Free
PDF
Jun Li; Hua Zhong; Ning Cai; Tinghao Luo; Juanjuan Li; Xiaodan Su; Xun Li; Xuan Qiu; Yongming Yang; Yuansheng Yuan; Minbin Yu
Tags: chinese (other dialects), chinese people, eye, older adult, prevalence
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4498-4504. doi:https://doi.org/10.1167/iovs.12-9429
National Eye Institute Visual Function Questionnaire or Indian Vision Function Questionnaire for Visually Impaired: A Conundrum Free
PDF
Vijaya K. Gothwal; Shailaja P. Reddy; Rebecca Sumalini; Seelam Bharani; Deepak K. Bagga
Tags: eye, questionnaires, rasch model, vision, precision
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4730-4738. doi:https://doi.org/10.1167/iovs.11-8776

Multidisciplinary Ophthalmic Imaging

Patterns of Ganglion Cell Complex and Nerve Fiber Layer Loss in Nonarteritic Ischemic Optic Neuropathy by Fourier-Domain Optical Coherence Tomography Free
PDF
Divya Aggarwal; Ou Tan; David Huang; Alfredo A. Sadun
Tags: ganglia, nerve fibers, nonarteritic anterior ischemic optic neuropathy, non-arteritic ischemic optic neuropathy, optical coherence tomography
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4539-4545. doi:https://doi.org/10.1167/iovs.11-9300
Spatial Correlation between Hyperpigmentary Changes on Color Fundus Photography and Hyperreflective Foci on SDOCT in Intermediate AMD Free
PDF
Francisco A. Folgar; Jessica H. Chow; Sina Farsiu; Wai T. Wong; Stefanie G. Schuman; Rachelle V. O'Connell; Katrina P. Winter; Emily Y. Chew; Thomas S. Hwang; Sunil K. Srivastava; Molly W. Harrington; Traci E. Clemons; Cynthia A. Toth
Tags: color, drusen, eye, fundus photography, hyperpigmentation
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4626-4633. doi:https://doi.org/10.1167/iovs.12-9813
Does Optic Nerve Head Size Variation Affect Circumpapillary Retinal Nerve Fiber Layer Thickness Measurement by Optical Coherence Tomography? Free
PDF
David Huang; Vikas Chopra; Ake Tzu-Hui Lu; Ou Tan; Brian Francis; Rohit Varma; Advanced Imaging for Glaucoma Study (AIGS) Group
Tags: magnification, optic disk, retinal nerve fiber layer, optical coherence tomography
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4990-4997. doi:https://doi.org/10.1167/iovs.11-8214

Nantotechnology and Regenerative Medicine

Cell Therapy Modulates Expression of Tax1-Binding Protein 1 and Synaptotagmin IV in a Model of Optic Nerve Lesion Free
PDF
Louise A. Mesentier-Louro; Juliana Coronel; Camila Zaverucha-do-Valle; Andre Mencalha; Bruno D. Paredes; Eliana Abdelhay; Rosalia Mendez-Otero; Marcelo F. Santiago
Tags: cell therapy, optic nerve, proteins, retina, gene expression
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4720-4729. doi:https://doi.org/10.1167/iovs.11-8198

Physiology and Pharmacology

Comparison of Choroidal and Optic Nerve Head Blood Flow Regulation during Changes in Ocular Perfusion Pressure Free
PDF
Doreen Schmidl; Agnes Boltz; Semira Kaya; Rene Werkmeister; Nikolaus Dragostinoff; Michael Lasta; Elzbieta Polska; Gerhard Garhöfer; Leopold Schmetterer
Tags: exercise, isometric, fluid flow, intraocular pressure, optic disk, perfusion
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4337-4346. doi:https://doi.org/10.1167/iovs.11-9055
Effects of Palmitoylethanolamide on Aqueous Humor Outflow Free
PDF
Akhilesh Kumar; Zhuanhong Qiao; Pritesh Kumar; Zhao-Hui Song
Tags: adenoviruses, antagonists, aqueous humor, mitogen-activated protein kinases, phosphorylation
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4416-4425. doi:https://doi.org/10.1167/iovs.11-9294
Targeted Administration into the Suprachoroidal Space Using a Microneedle for Drug Delivery to the Posterior Segment of the Eye Free
PDF
Samirkumar R. Patel; Damian E. Berezovsky; Bernard E. McCarey; Vladimir Zarnitsyn; Henry F. Edelhauser; Mark R. Prausnitz
Tags: drug delivery systems, drug delivery, targeted, eye, oryctolagus cuniculus, fluorescence
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4433-4441. doi:https://doi.org/10.1167/iovs.12-9872
Methylene Blue Protects Primary Rat Retinal Ganglion Cells from Cellular Senescence Free
PDF
Donald R. Daudt, III; Brett Mueller; Yong H. Park; Yi Wen; Thomas Yorio
Tags: cell survival, cellular senescence, cytochrome c oxidase, ethidium, hypoxia
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4657-4667. doi:https://doi.org/10.1167/iovs.12-9734
Retinal Vein Pulsation Is in Phase with Intracranial Pressure and Not Intraocular Pressure Free
PDF
William H. Morgan; Christopher R. P. Lind; Samuel Kain; Naeem Fatehee; Arul Bala; Dao-Yi Yu
Tags: central retinal vein, intracranial pressure, intraocular pressure, cardiac cycle
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4676-4681. doi:https://doi.org/10.1167/iovs.12-9837
Neuroprotective Effects of Nonfeminizing Estrogens in Retinal Photoreceptor Neurons Free
PDF
Everett Nixon; James W. Simpkins
Tags: cell survival, estrogen, glutamate, glutamates, neurons
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4739-4747. doi:https://doi.org/10.1167/iovs.12-9517
β-LGND2, an ERβ Selective Agonist, Inhibits Pathologic Retinal Neovascularization Free
PDF
Anand Giddabasappa; Jeetendra R. Eswaraka; Christina M. Barrett; Matthew N. Bauler; Zhongzhi Wu; Muralimohan Yepuru; Duane D. Miller; James T. Dalton
Tags: agonists, angiogenesis, hypoxia, mice, neovascularization, pathologic
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 5066-5075. doi:https://doi.org/10.1167/iovs.12-9627
The Effective Add Inherent in 2-Zone Negative Lenses Inhibits Eye Growth in Myopic Young Chicks Free
PDF
Yue Liu; Christine Wildsoet
Tags: eye, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 5085-5093. doi:https://doi.org/10.1167/iovs.12-9628

Retina

Layer-Specific Manganese-Enhanced MRI of the Retina in Light and Dark Adaptation Free
PDF
Bryan H. De La Garza; Guang Li; Yen-Yu I. Shih; Timothy Q. Duong
Tags: dark adaptation, magnetic resonance imaging, manganese, retina, eye
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4352-4358. doi:https://doi.org/10.1167/iovs.11-8826
A Phage Display-Based Approach to Investigate Abnormal Neovessels of the Retina Free
PDF
Magdalena Staniszewska; Xiaolin Gu; Carmelo Romano; Andrius Kazlauskas
Tags: bacteriophages, retina, peptides
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4371-4379. doi:https://doi.org/10.1167/iovs.12-9690
Correlation between Photoreceptor Layer Integrity and Visual Function in Patients with Stargardt Disease: Implications for Gene Therapy Free
PDF
Francesco Testa; Settimio Rossi; Andrea Sodi; Ilaria Passerini; Valentina Di Iorio; Michele Della Corte; Sandro Banfi; Enrico Maria Surace; Ugo Menchini; Alberto Auricchio; Francesca Simonelli
Tags: electroretinography, gene therapy, personal integrity, photoreceptors, stargardt's disease
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4409-4415. doi:https://doi.org/10.1167/iovs.11-8201
Quantitative Evaluation of Papilledema from Stereoscopic Color Fundus Photographs Free
PDF
Li Tang; Randy H. Kardon; Jui-Kai Wang; Mona K. Garvin; Kyungmoo Lee; Michael D. Abràmoff
Tags: color, fundus photography, optic disk, papilledema, volume
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4490-4497. doi:https://doi.org/10.1167/iovs.12-9803
Quantitative Analyses of High-Resolution 3D MR Images of Highly Myopic Eyes to Determine Their Shapes Free
PDF
Muka Moriyama; Kyoko Ohno-Matsui; Toshio Modegi; Junichi Kondo; Yoichi Takahashi; Makoto Tomita; Takashi Tokoro; Ikuo Morita
Tags: eye, software
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4510-4518. doi:https://doi.org/10.1167/iovs.12-9426
Oxidative and Endoplasmic Reticulum Stresses Mediate Apoptosis Induced by Modified LDL in Human Retinal Müller Cells Free
PDF
Mingyuan Wu; Shihe Yang; Michael H. Elliott; Dongxu Fu; Kenneth Wilson; Jing Zhang; Mei Du; Junping Chen; Timothy Lyons
Tags: apoptosis, low-density lipoproteins, suidae, stress, cell death
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4595-4604. doi:https://doi.org/10.1167/iovs.12-9910
Long-Term Characterization of Retinal Degeneration in rd1 and rd10 Mice Using Spectral Domain Optical Coherence Tomography Free
PDF
Mark E. Pennesi; Keith V. Michaels; Sienna S. Magee; Anastasiya Maricle; Sean P. Davin; Anupam K. Garg; Michael J. Gale; Daniel C. Tu; Yuquan Wen; Laura R. Erker; Peter J. Francis
Tags: diagnostic imaging, mice, optical coherence tomography, retinal degeneration, retina
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4644-4656. doi:https://doi.org/10.1167/iovs.12-9611
Double Concentric Autofluorescence Ring in NR2E3-p.G56R-Linked Autosomal Dominant Retinitis Pigmentosa Free
PDF
Pascal Escher; Hoai V. Tran; Veronika Vaclavik; Francois X. Borruat; Daniel F. Schorderet; Francis L. Munier
Tags: autofluorescence, family, retinitis pigmentosa, eye, pigment
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4754-4764. doi:https://doi.org/10.1167/iovs.11-8693
Progressive Retinal Degeneration in Transgenic Mice with Overexpression of Endothelin-1 in Vascular Endothelial Cells Free
PDF
Xue-Song Mi; Xu Zhang; Qian Feng; Amy Cheuk Yin Lo; Sookja Kim Chung; Kwok-Fai So
Tags: endothelin-1, mice, retina, retinal degeneration, protein overexpression
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4842-4851. doi:https://doi.org/10.1167/iovs.12-9999
Profiles of Macular Pigment Optical Density and Their Changes Following Supplemental Lutein and Zeaxanthin: New Results from the LUNA Study Free
PDF
Meike Zeimer; Martha Dietzel; Hans Werner Hense; Britta Heimes; Ulrike Austermann; Daniel Pauleikhoff
Tags: eye, laparoscopic uterosacral nerve ablation, lutein, optics, pigment
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4852-4859. doi:https://doi.org/10.1167/iovs.12-9713
Proliferative Vitreoretinopathy in the Swine–A New Model Free
PDF
Kazuhiko Umazume; Yoreh Barak; Kevin McDonald; LanHsin Liu; Henry J. Kaplan; Shigeo Tamiya
Tags: epiretinal membrane, eye, retinal pigment cell, suidae, vitreoretinopathy, proliferative
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4910-4916. doi:https://doi.org/10.1167/iovs.12-9768
The 1D4 Antibody Labels Outer Segments of Long Double Cone But Not Rod Photoreceptors in Zebrafish Free
PDF
Jun Yin; Jan Brocher; Bastian Linder; Anja Hirmer; Husvinee Sundaramurthi; Utz Fischer; Christoph Winkler
Tags: antibodies, retinal cone, rod photoreceptors, zebrafish, animals, transgenic
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4943-4951. doi:https://doi.org/10.1167/iovs.12-9511

Retinal Cell Biology

Sleeping Beauty Transposon-Mediated Transfection of Retinal and Iris Pigment Epithelial Cells Free
PDF
Sandra Johnen; Zsuzsanna Izsvák; Michael Stöcker; Nina Harmening; Anna Katharina Salz; Peter Walter; Gabriele Thumann
Tags: dna transposons, immune reconstitution inflammatory syndrome, interprofessional education, pigment, sleep
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4787-4796. doi:https://doi.org/10.1167/iovs.12-9951
Mitochondria DNA Replication and DNA Methylation in the Metabolic Memory Associated with Continued Progression of Diabetic Retinopathy Free
PDF
Shikha Tewari; Qing Zhong; Julia M Santos; Renu A Kowluru
Tags: diabetic retinopathy, dna methylation, dna, mitochondrial, memory, polymerase chain reaction
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4881-4888. doi:https://doi.org/10.1167/iovs.12-9732
Mitochondrial Inhibition in Rat Retinal Cell Cultures as a Model of Metabolic Compromise: Mechanisms of Injury and Neuroprotection Free
PDF
John P. M. Wood; Teresa Mammone; Glyn Chidlow; Tim Greenwell; Robert J. Casson
Tags: cell culture techniques, mass or substance concentration per volume, mechanism of injury, mitochondria, neuroglia
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4897-4909. doi:https://doi.org/10.1167/iovs.11-9171
Effects of Proinflammatory Cytokines on the Claudin-19 Rich Tight Junctions of Human Retinal Pigment Epithelium Free
PDF
Shaomin Peng; Geliang Gan; Veena S. Rao; Ron A. Adelman; Lawrence J. Rizzolo
Tags: cytokine, tight junctions, retinal pigment epithelium, culture media
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 5016-5028. doi:https://doi.org/10.1167/iovs.11-8311

Translational

Refractive Lenticule Re-Implantation after Myopic ReLEx: A Feasibility Study of Stromal Restoration after Refractive Surgery in a Rabbit Model Free
PDF
Romesh I. Angunawela; Andri K. Riau; Shyam S. Chaurasia; Donald T. Tan; Jodhbir S. Mehta
Tags: cornea, oryctolagus cuniculus, surgical ocular refractive procedure, surgical replantation, feasibility studies
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4975-4985. doi:https://doi.org/10.1167/iovs.12-10170

Visual Neuroscience

Circadian and Wake-Dependent Effects on the Pupil Light Reflex in Response to Narrow-Bandwidth Light Pulses Free
PDF
Mirjam Münch; Lorette Léon; Sylvain V. Crippa; Aki Kawasaki
Tags: blue light, drowsiness, melanopsin, melatonin, pupil
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4546-4555. doi:https://doi.org/10.1167/iovs.12-9494

Visual Psychophysics and Physiological Optics

Visual Performance with Wave Aberration Correction after Penetrating, Deep Anterior Lamellar, or Endothelial Keratoplasty Free
PDF
Seth M. Pantanelli; Ramkumar Sabesan; Steven S. T. Ching; Geunyoung Yoon; Holly B. Hindman
Tags: contrast sensitivity, descemet stripping endothelial keratoplasty, endothelium, keratoplasty, optics
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4797-4804. doi:https://doi.org/10.1167/iovs.12-10003

Clinical Trials

Evaluations of Tear Protein Markers in Dry Eye Disease: Repeatability of Measurement and Correlation with Disease Free
PDF
Jing-Feng Huang; Yi Zhang; Kay D. Rittenhouse; Eve H. Pickering; Michael T. McDowell
Tags: dry eye syndromes, proteins, interleukin-8, eye
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4556-4564. doi:https://doi.org/10.1167/iovs.11-9054

Letters to the Editor

Is Drusen Area Really So Important? Free
PDF
Gui-shuang Ying
Tags: drusen
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4407-4408. doi:https://doi.org/10.1167/iovs.12-10032
Accuracy, Validity, and Reliability of the Infrared Optical Head Tracker (IOHT) Free
PDF
Siamak Sabour; Fariba Ghassemi
Tags: optics, reliability, validity of results
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4776. doi:https://doi.org/10.1167/iovs.12-10324
An Analysis of the Use of Multiple Comparison Corrections in Ophthalmology Research Free
PDF
Carrie Huisingh; Gerald McGwin, Jr
Tags: ophthalmology
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4777. doi:https://doi.org/10.1167/iovs.12-10336
Author Response: The Association between Glaucoma Prevalence and Supplementation with the Oxidants Calcium and Iron Free
PDF
Kuldev Singh; Sophia Y. Wang; Shan C. Lin
Tags: calcium, glaucoma, iron, oxidants, prevalence
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4940. doi:https://doi.org/10.1167/iovs.12-10433
The Association between Glaucoma Prevalence and Supplementation with the Oxidants Calcium and Iron Free
PDF
Yahya Shaikh; Fei Yu; Anne L. Coleman
Tags: calcium, glaucoma, iron, oxidants, prevalence
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 4941-4942. doi:https://doi.org/10.1167/iovs.12-10315

Erratum

Erratum Free
PDF
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 5076. doi:https://doi.org/10.1167/iovs.11-8114a
Erratum Free
PDF
Investigative Ophthalmology & Visual Science July 2012, Vol.53, 5094. doi:https://doi.org/10.1167/iovs.11-9110a
Copyright © 2025 Association for Research in Vision and Ophthalmology.
×
×

This PDF is available to Subscribers Only

Sign in or purchase a subscription to access this content. ×

You must be signed into an individual account to use this feature.

×