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Anatomy and Pathology/Oncology

Lacrimal Gland Involvement in Graft-Versus-Host Disease: A Murine Model Free
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Adam S. Hassan; Shawn G. Clouthier; James L. M. Ferrara; Alexandra Stepan; Shahzad I. Mian; Amjad Z. Ahmad; Victor M. Elner
Tags: graft-versus-host disease, lacrimal gland, histopathology tests
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2692-2697. doi:https://doi.org/10.1167/iovs.05-0040
Shape of the Retinal Surface in Emmetropia and Myopia Free
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David A. Atchison; Nicola Pritchard; Katrina L. Schmid; Dion H. Scott; Catherine E. Jones; James M. Pope
Tags: emmetropia, eye, myopia, retina, sclera
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2698-2707. doi:https://doi.org/10.1167/iovs.04-1506

Biochemistry and Molecular Biology

Expression of the IGF System in Normal and Diabetic Transgenic (mRen-2)27 Rat Eye Free
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Philip B. Bergman; Christina J. Moravski; Stephanie R. Edmondson; Vincenzo C. Russo; Leon A. Bach; Jennifer L. Wilkinson-Berka; George A. Werther
Tags: animals, transgenic, diabetes mellitus, eye, rna, messenger, insulin-like growth factor i
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2708-2715. doi:https://doi.org/10.1167/iovs.04-0921
Oligodendrocyte Dysfunction after Induction of Experimental Anterior Optic Nerve Ischemia Free
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Nitza Goldenberg-Cohen; Yan Guo; Frank Margolis; Yoram Cohen; Neil R. Miller; Steven L. Bernstein
Tags: demyelination, eye, ischemia, mice, neurons
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2716-2725. doi:https://doi.org/10.1167/iovs.04-0547
Identification of a Novel Splice Site Mutation of the CSPG2 Gene in a Japanese Family with Wagner Syndrome Free
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Tatsuro Miyamoto; Hiroshi Inoue; Yukiko Sakamoto; Eiji Kudo; Takeshi Naito; Takako Mikawa; Yoichi Mikawa; Yasushi Isashiki; Dai Osabe; Shuichi Shinohara; Hiroshi Shiota; Mitsuo Itakura
Tags: family, genes, japanese, wagner syndrome, splice-site mutation
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2726-2735. doi:https://doi.org/10.1167/iovs.05-0057
Pigment Epithelium–Derived Factor Is a Substrate for Matrix Metalloproteinase Type 2 and Type 9: Implications for Downregulation in Hypoxia Free
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Luigi Notari; Amanda Miller; Alfredo Martínez; Juan Amaral; Meihua Ju; Gregory Robinson; Lois E. H. Smith; S. Patricia Becerra
Tags: gelatinase a, hypoxia, matrix metalloproteinases, pigment, proteins
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2736-2747. doi:https://doi.org/10.1167/iovs.04-1489

Clinical and Epidemiologic Research

Distribution of Ocular Biometric Parameters and Refraction in a Population-Based Study of Australian Children Free
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Elvis Ojaimi; Kathryn A. Rose; Ian G. Morgan; Wayne Smith; Frank J. Martin; Annette Kifley; Dana Robaei; Paul Mitchell
Tags: anterior chamber of eye, biometry, child, cornea, refraction
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2748-2754. doi:https://doi.org/10.1167/iovs.04-1324
Converting to SITA-Standard from Full-Threshold Visual Field Testing in the Follow-up Phase of a Clinical Trial Free
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David C. Musch; Brenda W. Gillespie; Bonnie M. Motyka; Leslie M. Niziol; Richard P. Mills; Paul R. Lichter
Tags: follow-up, laboratory test finding, visual field testing, glaucoma, depression, post-stroke
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2755-2759. doi:https://doi.org/10.1167/iovs.05-0006
The Changing Prevalence of Myopia in Young Adults: A 13-Year Series of Population-Based Prevalence Surveys Free
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Yosefa Bar Dayan; Avi Levin; Yair Morad; Itamar Grotto; Rachel Ben-David; Avishai Goldberg; Erez Onn; Isaac Avni; Yehezkel Levi; Oren Gil Benyamini
Tags: myopia, prevalence, surveys, young adult
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2760-2765. doi:https://doi.org/10.1167/iovs.04-0260

Cornea

The Controlled-Environment Chamber: A New Mouse Model of Dry Eye Free
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Stefano Barabino; LinLing Shen; Lu Chen; Saadia Rashid; Maurizio Rolando; M. Reza Dana
Tags: conjunctiva, controlled environment, cornea, dry eye syndromes, fluorescein stain method
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2766-2771. doi:https://doi.org/10.1167/iovs.04-1326
Differential Modulation of Allergic Eye Disease by Chronic and Acute Ascaris Infection Free
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Lisa Schopf; Stefano Luccioli; Virgilio Bundoc; Paul Justice; Chi-Chao Chan; Brittany J. Wetzel; Hillary H. Norris; Joseph F. Urban, Jr; Andrea Keane-Myers
Tags: antigens, ascariasis, conjunctiva, eosinophils, eye diseases
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2772-2780. doi:https://doi.org/10.1167/iovs.04-0899
Nitric Oxide and cGMP Mediate α1D-Adrenergic Receptor–Stimulated Protein Secretion and p42/p44 MAPK Activation in Rat Lacrimal Gland Free
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Robin R. Hodges; Marie A. Shatos; Rachel S. Tarko; Joanna Vrouvlianis; Jian Gu; Darlene A. Dartt
Tags: agonists, cyclic gmp, lacrimal gland, mitogen-activated protein kinases, nitric oxide synthase
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2781-2789. doi:https://doi.org/10.1167/iovs.05-0022

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Superior Oblique Muscle Layers in Monkeys and Humans Free
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Reika Kono; Vadims Poukens; Joseph L. Demer
Tags: cercopithecidae, superior oblique muscle, magnetic resonance imaging, orbit, muscle
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2790-2799. doi:https://doi.org/10.1167/iovs.04-1147
Kinematics of Vertical Saccades during the Yaw Vestibulo-ocular Reflex in Humans Free
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Benjamin T. Crane; Junru Tian; Joseph L. Demer
Tags: eye, reflex, vestibulo-ocular, saccades, velocity, yaws
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2800-2809. doi:https://doi.org/10.1167/iovs.05-0147
Binocular Summation of Detection and Resolution Thresholds in the Central Visual Field Using Parallel-Line Targets Free
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Akemi Wakayama; Chota Matsumoto; Yoshikazu Shimomura
Tags: summation, visual fields
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2810-2815. doi:https://doi.org/10.1167/iovs.04-1421

Glaucoma

Clinical Features and Course of Patients with Glaucoma with the E50K Mutation in the Optineurin Gene Free
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Tin Aung; Tayebeh Rezaie; Koji Okada; Ananth C. Viswanathan; Anne H. Child; Glen Brice; Shomi S. Bhattacharya; Ordan J. Lehmann; Mansoor Sarfarazi; Roger A. Hitchings
Tags: genes, glaucoma, mutation, optn gene, visual fields
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2816-2822. doi:https://doi.org/10.1167/iovs.04-1133
Laser Scanning Tomography of the Optic Nerve Head in a Normal Elderly Population: The Bridlington Eye Assessment Project Free
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Stephen A. Vernon; Matthew J. Hawker; Gerard Ainsworth; Jonathan G. Hillman; Hamish K. MacNab; Harminder S. Dua
Tags: eye, lasers, older adult, optic disk, tomography
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2823-2828. doi:https://doi.org/10.1167/iovs.05-0087
Hypophosphorylation of Aqueous Humor sCD44 and Primary Open-Angle Glaucoma Free
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Paul A. Knepper; Adam M. Miller; John Choi; Robert D. Wertz; Michael J. Nolan; William Goossens; Susan Whitmer; Beatrice Y. J. T. Yue; Robert Ritch; Jeffrey M. Liebmann; R. Rand Allingham; John R. Samples
Tags: aqueous humor, open-angle glaucoma, phosphorylation, cd44 antigens, antibodies
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2829-2837. doi:https://doi.org/10.1167/iovs.04-1472
Analysis of GDx-VCC Polarimetry Data by Wavelet-Fourier Analysis across Glaucoma Stages Free
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Edward A. Essock; Yufeng Zheng; Pinakin Gunvant
Tags: eye, glaucoma
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2838-2847. doi:https://doi.org/10.1167/iovs.04-1156
Primary Trabecular Meshwork Cells Incubated in Human Aqueous Humor Differ from Cells Incubated in Serum Supplements Free
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Michael P. Fautsch; Kyle G. Howell; Anne M. Vrabel; M. Cristine Charlesworth; David C. Muddiman; Douglas H. Johnson
Tags: aqueous humor, ascorbic acid, culture media, conditioned, hypertension, proteins
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2848-2856. doi:https://doi.org/10.1167/iovs.05-0101
Changes in Gene Expression by Trabecular Meshwork Cells in Response to Mechanical Stretching Free
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Vasavi Vittal; Anastasia Rose; Kate E. Gregory; Mary J. Kelley; Ted S. Acott
Tags: gene expression, genes, stretching exercises, trabecular meshwork, proteins
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2857-2868. doi:https://doi.org/10.1167/iovs.05-0075

Lens

Molecular Characterization of the Cystine/Glutamate Exchanger and the Excitatory Amino Acid Transporters in the Rat Lens Free
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Julie Lim; Yee Chai Lam; Joerg Kistler; Paul J. Donaldson
Tags: cystine, excitatory amino acids, glutamate, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2869-2877. doi:https://doi.org/10.1167/iovs.05-0156

Retina

Monocarboxylate Transporter Expression Remains Unchanged during the Development of Diabetic Retinal Neuropathy in the Rat Free
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Christopher J. Layton; Glyn Chidlow; Robert J. Casson; John P. M. Wood; Mark Graham; Neville N. Osborne
Tags: diabetes mellitus, monocarboxylic acid transporters, neuropathy, retina
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2878-2885. doi:https://doi.org/10.1167/iovs.04-1458
Eye-Movement Training for Reading in Patients with Age-Related Macular Degeneration Free
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William Seiple; Janet P. Szlyk; Timothy McMahon; Jose Pulido; Gerald A. Fishman
Tags: eye movement, reading (activity), training, exercise, saccades
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2886-2896. doi:https://doi.org/10.1167/iovs.04-1296
Retinoid X Receptor γ Is Necessary to Establish the S-opsin Gradient in Cone Photoreceptors of the Developing Mouse Retina Free
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Melanie R. Roberts; Anita Hendrickson; Christopher R. McGuire; Thomas A. Reh
Tags: mice, opsin, retina, retinal cone, retinoid x receptor
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2897-2904. doi:https://doi.org/10.1167/iovs.05-0093
Targeted Disruption of FSCN2 Gene Induces Retinopathy in Mice Free
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Shunji Yokokura; Yuko Wada; Shigeyasu Nakai; Hajime Sato; Ryoji Yao; Hitomi Yamanaka; Sioko Ito; Yoshiko Sagara; Mayumi Takahashi; Yukie Nakamura; Makoto Tamai; Tetsuo Noda
Tags: genes, mice, retinal diseases, retina
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2905-2915. doi:https://doi.org/10.1167/iovs.04-0856
The RAGE Axis in Early Diabetic Retinopathy Free
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Gaetano R. Barile; Sophia I. Pachydaki; Samir R. Tari; Song E. Lee; Christine M. Donmoyer; Wanchao Ma; Ling Ling Rong; Loredana G. Buciarelli; Thoralf Wendt; Heidi Hörig; Barry I. Hudson; Wu Qu; Alan D. Weinberg; Shi Fang Yan; Ann Marie Schmidt
Tags: diabetic retinopathy, mice, rage, retina, hyperglycemic agents
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2916-2924. doi:https://doi.org/10.1167/iovs.04-1409
Suppression of Ocular Inflammation in Endotoxin-Induced Uveitis by Blocking the Angiotensin II Type 1 Receptor Free
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Norihiro Nagai; Yuichi Oike; Kousuke Noda; Takashi Urano; Yoshiaki Kubota; Yoko Ozawa; Hajime Shinoda; Takashi Koto; Kei Shinoda; Makoto Inoue; Kazuo Tsubota; Kenji Yamashiro; Toshio Suda; Susumu Ishida
Tags: endotoxins, eye inflammation, intercellular adhesion molecule 1, receptor, angiotensin, type 1, telmisartan
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2925-2931. doi:https://doi.org/10.1167/iovs.04-1476
A System for Inducible Gene Expression in Retinal Ganglion Cells Free
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John B. Kerrison; Elia J. Duh; Yilin Yu; Deborah C. Otteson; Donald J. Zack
Tags: doxycycline, galactosidase, gene expression, mice, retina
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2932-2939. doi:https://doi.org/10.1167/iovs.04-1237
Autofluorescence Characteristics of Normal Foveas and Reconstruction of Foveal Autofluorescence from Limited Data Subsets Free
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R. Theodore Smith; Jan P. Koniarek; Jackie Chan; Takayuki Nagasaki; Janet R. Sparrow; Kevin Langton
Tags: autofluorescence, reconstructive surgical procedures, fovea centralis, eye, pixel
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2940-2946. doi:https://doi.org/10.1167/iovs.04-0778
Prolactins Are Natural Inhibitors of Angiogenesis in the Retina Free
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Jorge Aranda; José C. Rivera; Michael C. Jeziorski; Juan Riesgo-Escovar; Gabriel Nava; Fernándo López-Barrera; Hugo Quiróz-Mercado; Peter Berger; Gonzalo Martínez de la Escalera; Carmen Clapp
Tags: angiogenesis, retina, rna, small interfering, antibodies, angiogenesis inhibitors
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2947-2953. doi:https://doi.org/10.1167/iovs.05-0173
Drug Intervention Can Correct Subnormal Retinal Oxygenation Response in Experimental Diabetic Retinopathy Free
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Bruce A. Berkowitz; Robin Roberts; Hongmei Luan; Jamie Peysakhov; Deborah L. Knoerzer; Jane R. Connor; Thomas C. Hohman
Tags: alcohol intervention, alveolar ventilation function, cell respiration, diabetes mellitus, diabetic retinopathy
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2954-2960. doi:https://doi.org/10.1167/iovs.05-0132
Retinal Contraction and Metamorphopsia Scores in Eyes with Idiopathic Epiretinal Membrane Free
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Eiko Arimura; Chota Matsumoto; Sachiko Okuyama; Sonoko Takada; Shigeki Hashimoto; Yoshikazu Shimomura
Tags: epiretinal membrane, eye, metamorphopsias
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2961-2966. doi:https://doi.org/10.1167/iovs.04-1104
Contrast Response Properties of Magnocellular and Parvocellular Pathways in Retinitis Pigmentosa Assessed by the Visual Evoked Potential Free
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Kenneth R. Alexander; Aruna S. Rajagopalan; William Seiple; Vance M. Zemon; Gerald A. Fishman
Tags: evoked potentials, visual, luminance, retinitis pigmentosa
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2967-2973. doi:https://doi.org/10.1167/iovs.05-0231

Retinal Cell Biology

Effects of Oxidized and Glycated LDL on Gene Expression in Human Retinal Capillary Pericytes Free
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Weiwei Song; Jeremy L. Barth; Yongxin Yu; Kangmo Lu; Azar Dashti; Yan Huang; Cynthia K. Gittinger; W. Scott Argraves; Timothy J. Lyons
Tags: genes, low-density lipoproteins, pericytes, suidae, gene expression
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2974-2982. doi:https://doi.org/10.1167/iovs.04-1505
Retinal-Cell–Conditioned Medium Prevents TNF-α-Induced Apoptosis of Purified Ganglion Cells Free
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Céline Fuchs; Valérie Forster; Elise Balse; José-Alain Sahel; Serge Picaud; Luc-Henri Tessier
Tags: cell culture techniques, culture media, conditioned, ischemia, tumor necrosis factors, longitudinal relaxation rate
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2983-2991. doi:https://doi.org/10.1167/iovs.04-1177
Identification of Sequential Events and Factors Associated with Microglial Activation, Migration, and Cytotoxicity in Retinal Degeneration in rd Mice Free
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Hui-yang Zeng; Xiu-an Zhu; Cheng Zhang; Li-Ping Yang; Le-meng Wu; Mark O. M. Tso
Tags: cytotoxicity, mice, photoreceptors, retina, retinal degeneration
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2992-2999. doi:https://doi.org/10.1167/iovs.05-0118
Identification of P2Y Receptor Subtypes in Human Müller Glial Cells by Physiology, Single Cell RT-PCR, and Immunohistochemistry Free
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Julia E. Fries; Iwona M. Goczalik; Thomas H. Wheeler-Schilling; Konrad Kohler; Elke Guenther; Sebastian Wolf; Peter Wiedemann; Andreas Bringmann; Andreas Reichenbach; Mike Francke; Thomas Pannicke
Tags: immunohistochemistry, neuroglia, physiology, reverse transcriptase polymerase chain reaction, polymerase chain reaction
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 3000-3007. doi:https://doi.org/10.1167/iovs.05-0043

Visual Psychophysics and Physiological Optics

A Residual Deficit for Global Motion Processing after Acuity Recovery in Deprivation Amblyopia Free
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Thomas Constantinescu; Laura Schmidt; Richard Watson; Robert F. Hess
Tags: deprivation amblyopia, motion, recovery of function, eye, amblyopia
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 3008-3012. doi:https://doi.org/10.1167/iovs.05-0242

Clinical Trials

Preschool Vision Screening Tests Administered by Nurse Screeners Compared with Lay Screeners in the Vision in Preschoolers Study Free
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Tags: child, nurses, preschool child, screening, screening test
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2639-2648. doi:https://doi.org/10.1167/iovs.05-0141

Lecture

Introducing Simon John, the 2004 Recipient of the Cogan Award Free
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Richard S. Smith
Tags: awards and prizes
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2649. doi:https://doi.org/10.1167/iovs.04-1069
Mechanistic Insights into Glaucoma Provided by Experimental Genetics The Cogan Lecture Free
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Simon W. M. John
Tags: glaucoma, mice, genetics, intraocular pressure
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2650-2661. doi:https://doi.org/10.1167/iovs.05-0205
Introducing Harry A. Quigley, the 2004 Recipient of the Friedenwald Award Free
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Douglas R. Anderson
Tags: awards and prizes
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2662. doi:https://doi.org/10.1167/iovs.04-1068
Glaucoma: Macrocosm to Microcosm The Friedenwald Lecture Free
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Harry A. Quigley
Tags: glaucoma, risk factors, death
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2663-2670. doi:https://doi.org/10.1167/iovs.04-1070
Introducing Charlotte Remé, the 2004 Recipient of the Proctor Medal Free
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François Delori
Tags: attention, autophagy, eye, love, photoreceptors
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2671. doi:https://doi.org/10.1167/iovs.04-1094
The Dark Side of Light: Rhodopsin and the Silent Death of Vision The Proctor Lecture Free
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Charlotte E. Remé
Tags: apoptosis, rhodopsin, vision, proteins, retina
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2672-2682. doi:https://doi.org/10.1167/iovs.04-1095
Introducing David H. Abramson, the 2004 Recipient of the Weisenfeld Award Free
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Barrett G. Haik
Tags: awards and prizes
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2683. doi:https://doi.org/10.1167/iovs.04-1067
Retinoblastoma in the 20th Century: Past Success and Future Challenges The Weisenfeld Lecture Free
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David H. Abramson
Tags: cancer, retinoblastoma, radiation
Investigative Ophthalmology & Visual Science August 2005, Vol.46, 2684-2691. doi:https://doi.org/10.1167/iovs.04-1462
Copyright © 2025 Association for Research in Vision and Ophthalmology.
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