Volume 51 Issue 1 | IOVS

State of the Journal Free

Paul L. Kaufman

Tags: color, diagnostic imaging, journal impact factor, lens (device), vision

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 1. doi:https://doi.org/10.1167/iovs.09-4980

Analysis of p53 Mutations and the Expression of p53 and p21^WAF1/CIP1 Protein in 15 Cases of Sebaceous Carcinoma of the Eyelid Free

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Kunihiro Kiyosaki; Chisato Nakada; Naoki Hijiya; Yoshiyuki Tsukamoto; Keiko Matsuura; Kazuo Nakatsuka; Tsutomu Daa; Shigeo Yokoyama; Masamoto Imaizumi; Masatsugu Moriyama

Tags: eyelid, mutation, proteins, sebaceous adenocarcinoma, tp53 gene

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 7-11. doi:https://doi.org/10.1167/iovs.09-4127

Proteomics of Uveal Melanomas Suggests HSP-27 as a Possible Surrogate Marker of Chromosome 3 Loss Free

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Sarah E. Coupland; Henrik Vorum; Nakul Mandal; Helen Kalirai; Bent Honoré; Steen Fiil Urbak; Sarah L. Lake; Justyna Dopierala; Bertil Damato

Tags: chromosomes, human, pair 3, monosomy, proteins, uveal melanoma, vimentin

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 12-20. doi:https://doi.org/10.1167/iovs.09-3913

Analysis of Postnatal Eye Development in the Mouse with High-Resolution Small Animal Magnetic Resonance Imaging Free

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Tatiana V. Tkatchenko; Yimin Shen; Andrei V. Tkatchenko

Tags: eye, eye development, magnetic resonance imaging, mice

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 21-27. doi:https://doi.org/10.1167/iovs.08-2767

Constitutive Overexpression of Pigment Epithelium–Derived Factor Inhibition of Ocular Melanoma Growth and Metastasis Free

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Hua Yang; Hans E. Grossniklaus

Tags: epithelium, eye melanomas, melanoma, mice, neoplasm metastasis

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 28-34. doi:https://doi.org/10.1167/iovs.09-4138

Biochemistry and Molecular Biology

ERK- and Akt-Dependent Neuroprotection by Erythropoietin (EPO) against Glyoxal-AGEs via Modulation of Bcl-xL, Bax, and BAD Free

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Jianfeng Shen; Yalan Wu; Jing-Ying Xu; Jingfa Zhang; Stephen H. Sinclair; Myron Yanoff; Guoxu Xu; Weiye Li; Guo-Tong Xu

Tags: bcl-xl protein, glyoxal, neuroprotection, proto-oncogene proteins c-akt, erythropoietin

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 35-46. doi:https://doi.org/10.1167/iovs.09-3544

Brittle Cornea Syndrome Associated with a Missense Mutation in the Zinc-Finger 469 Gene Free

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Anne E. Christensen; Per M. Knappskog; Marit Midtbø; Clara G. Gjesdal; Jonas Mengel-From; Niels Morling; Eyvind Rødahl; Helge Boman

Tags: ehlers-danlos syndrome 6b, genes, missense mutation, zinc fingers, mutation

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 47-52. doi:https://doi.org/10.1167/iovs.09-4251

Association of Neovascular Age-Related Macular Degeneration with Specific Gene Expression Patterns in Peripheral White Blood Cells Free

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Michal Lederman; Avraham Weiss; Itay Chowers

Tags: exudative age-related macular degeneration, gene expression, leukocytes, single nucleotide polymorphism, genotype determination

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 53-58. doi:https://doi.org/10.1167/iovs.08-3019

The Involvement of Complement Factor B and Complement Component C2 in an Indian Cohort with Age-Related Macular Degeneration Free

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Inderjeet Kaur; Saritha Katta; Rajeev K. Reddy; Raja Narayanan; Annie Mathai; Ajit B. Majji; Subhabrata Chakrabarti

Tags: age-related macular degeneration, cohort studies, complement 2, complement factor b, single nucleotide polymorphism

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 59-63. doi:https://doi.org/10.1167/iovs.09-4135

Inhibition of JAK2/STAT3-Mediated VEGF Upregulation under High Glucose Conditions by PEDF through a Mitochondrial ROS Pathway In Vitro Free

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Zhi Zheng; Haibing Chen; Hui Zhao; Kun Liu; Dawei Luo; Yongdong Chen; Yihui Chen; Xiaolu Yang; Qing Gu; Xun Xu

Tags: glucose, mitochondria, stat3 protein, up-regulation (physiology), vascular endothelial growth factor a

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 64-71. doi:https://doi.org/10.1167/iovs.09-3511

Functional Role of Proteolytic Processing of Recombinant Myocilin in Self-Aggregation Free

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José-Daniel Aroca-Aguilar; Francisco Martínez-Redondo; Francisco Sánchez-Sánchez; Miguel Coca-Prados; Julio Escribano

Tags: myoc gene, recombinant proteins

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 72-78. doi:https://doi.org/10.1167/iovs.09-4118

ARMS2 Is a Constituent of the Extracellular Matrix Providing a Link between Familial and Sporadic Age-Related Macular Degenerations Free

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Elod Kortvely; Stefanie M. Hauck; Gabriele Duetsch; Christian J. Gloeckner; Elisabeth Kremmer; Claudia S. Alge-Priglinger; Cornelia A. Deeg; Marius Ueffing

Tags: extracellular matrix, eye, macular degeneration, proteins, yeast one/two-hybrid system

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 79-88. doi:https://doi.org/10.1167/iovs.09-3850

Clinical and Epidemiologic Research

Oligocone Trichromacy: Clinical and Molecular Genetic Investigations Free

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Mette K. G. Andersen; Nynne L. B. Christoffersen; Birgit Sander; Carsten Edmund; Michael Larsen; Tanja Grau; Bernd Wissinger; Susanne Kohl; Thomas Rosenberg

Tags: achromatopsia, color vision, electroretinography, genetics, molecular, retinal cone

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 89-95. doi:https://doi.org/10.1167/iovs.09-3988

Association of the Lumican Gene Functional 3′-UTR Polymorphism with High Myopia Free

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Hui-Ju Lin; Yung-Jen Kung; Ying-Ju Lin; Jim J. C. Sheu; Bing-Hung Chen; Yu-Ching Lan; Chih-Ho Lai; Yu-An Hsu; Lei Wan; Fuu Jen Tsai

Tags: genes, myopia, polymorphism, single nucleotide polymorphism, genotype

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 96-102. doi:https://doi.org/10.1167/iovs.09-3612

Distribution and Determinants of Ocular Biometric Parameters in an Asian Population: The Singapore Malay Eye Study Free

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Laurence Shen Lim; Seang-Mei Saw; V. Swetha E. Jeganathan; Wan Ting Tay; Tin Aung; Louis Tong; Paul Mitchell; Tien Yin Wong

Tags: asian, biometry, eye, singapore, chief complaint

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 103-109. doi:https://doi.org/10.1167/iovs.09-3553

Impact of Cataract Screening Outreach in Rural China Free

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Mingzhi Zhang; Jing Wu; Liping Li; Daocheng Xu; Dennis S. C. Lam; Jack Lee; Sian Griffiths; Nathan Congdon

Tags: cataract, china, outreach, screening, cataract surgery

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 110-114. doi:https://doi.org/10.1167/iovs.09-4190

Early Childhood Refractive Error and Parental History of Myopia as Predictors of Myopia Free

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Lisa A. Jones-Jordan; Loraine T. Sinnott; Ruth E. Manny; Susan A. Cotter; Robert N. Kleinstein; Donald O. Mutti; J. Daniel Twelker; Karla Zadnik; the Collaborative Longitudinal Evaluation of Ethnicity and Refractive Error (CLEERE) Study Group

Tags: child, family history, myopia, parent, refractive errors

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 115-121. doi:https://doi.org/10.1167/iovs.08-3210

Cornea

Changes in Corneal Epithelial Layer Inflammatory Cells in Aqueous Tear–Deficient Dry Eye Free

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Hui Lin; Wei Li; Nuo Dong; Wensheng Chen; Jing Liu; Lelei Chen; Hongxia Yuan; Zhixin Geng; Zuguo Liu

Tags: cornea, corneal epithelium, dry eye syndromes, epithelium, inflammatory cells

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 122-128. doi:https://doi.org/10.1167/iovs.09-3629

Mechanisms of Corneal Tissue Cross-linking in Response to Treatment with Topical Riboflavin and Long-Wavelength Ultraviolet Radiation (UVA) Free

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A. Scott McCall; Stefan Kraft; Henry F. Edelhauser; George W. Kidder; Richard R. Lundquist; Helen E. Bradshaw; Zinaida Dedeic; Megan J. C. Dionne; Ethan M. Clement; Gary W. Conrad

Tags: body tissue, cornea, cross-linking, riboflavin, ultraviolet a radiation

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 129-138. doi:https://doi.org/10.1167/iovs.09-3738

Role of Periostin and Interleukin-4 in Recurrence of Pterygia Free

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Chuan-Hui Kuo; Dai Miyazaki; Keiko Yakura; Kaoru Araki-Sasaki; Yoshitsugu Inoue

Tags: interleukin-4, pterygium, recurrence, fibroblasts

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 139-143. doi:https://doi.org/10.1167/iovs.09-4022

Conjunctival In Vivo Confocal Scanning Laser Microscopy in Patients with Sjögren Syndrome Free

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Tais Hitomi Wakamatsu; Enrique Adan Sato; Yukihiro Matsumoto; Osama M. A. Ibrahim; Murat Dogru; Minako Kaido; Reiko Ishida; Kazuo Tsubota

Tags: conjunctiva, microscopy, confocal scanning laser, sjogren's syndrome, microscopy, confocal, epithelium

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 144-150. doi:https://doi.org/10.1167/iovs.08-2722

Functional Role of Thymic Stromal Lymphopoietin in Chronic Allergic Keratoconjunctivitis Free

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Akira Matsuda; Nobuyuki Ebihara; Norihiko Yokoi; Satoshi Kawasaki; Hidetoshi Tanioka; Tsutomu Inatomi; Rene de Waal Malefyt; Junji Hamuro; Shigeru Kinoshita; Akira Murakami

Tags: thymic stromal lymphopoietin, rna, messenger, keratoconjunctivitis

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 151-155. doi:https://doi.org/10.1167/iovs.09-4183

A Novel Method for Pachymetry Mapping of Human Precorneal Tear Film Using Pentacam with Fluorescein Free

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Hong Zhuang; Xingtao Zhou; Jianjiang Xu

Tags: fluorescein, optical pachymetry, tear film finding, dry eye syndromes, eye

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 156-159. doi:https://doi.org/10.1167/iovs.08-3265

Genetic Dependence of Central Corneal Thickness among Inbred Strains of Mice Free

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Geoffrey D. Lively; Bing Jiang; Adam Hedberg-Buenz; Bo Chang; Greg E. Petersen; Kai Wang; Markus H. Kuehn; Michael G. Anderson

Tags: cornea, genetics, mice, mice, inbred strains, optical pachymetry

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 160-171. doi:https://doi.org/10.1167/iovs.09-3429

Prevention of UV-Induced Damage to the Anterior Segment Using Class I UV-Absorbing Hydrogel Contact Lenses Free

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Heather L. Chandler; Kathleen S. Reuter; Loraine T. Sinnott; Jason J. Nichols

Tags: contact lenses, cornea, eye, hydrogel, lens, crystalline

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 172-178. doi:https://doi.org/10.1167/iovs.09-3996

Evidence for Facial Nerve–Independent Mechanisms of Blinking in the Rat Free

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James T. Heaton; Jeffrey Kowaleski; Colin Edwards; Christopher Smitson; Tessa A. Hadlock

Tags: blinking, cornea, facial nerve, health, rats

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 179-182. doi:https://doi.org/10.1167/iovs.08-3371

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Effects of Elevated Thyroid Hormone on Adult Rabbit Extraocular Muscles Free

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Andrew R. Harrison; Michael S. Lee; Linda K. McLoon

Tags: adult, muscle of orbit, oryctolagus cuniculus, protein isoforms, thyroid hormones

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 183-191. doi:https://doi.org/10.1167/iovs.09-3681

Perimysial Fibroblasts of Extraocular Muscle, as Unique as the Muscle Fibers Free

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Linda L. Kusner; Andrew Young; Steven Tjoe; Patrick Leahy; Henry J. Kaminski

Tags: coculture techniques, dna microarrays, fibroblasts, muscle fibers, muscle of orbit

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 192-200. doi:https://doi.org/10.1167/iovs.08-2857

Relationship between Static Ocular Counterroll and Bielschowsky Head Tilt Phenomenon Free

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Ichiro Hamasaki; Satoshi Hasebe; Takashi Furuse; Hiroshi Ohtsuki

Tags: eye, hypertropia, muscle, paralysis, surgery specialty

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 201-206. doi:https://doi.org/10.1167/iovs.08-3035

Glaucoma

The Microbead Occlusion Model: A Paradigm for Induced Ocular Hypertension in Rats and Mice Free

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Rebecca M. Sappington; Brian J. Carlson; Samuel D. Crish; David J. Calkins

Tags: eye, intraocular pressure, mice, microspheres, ocular hypertension

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 207-216. doi:https://doi.org/10.1167/iovs.09-3947

Evaluation of Retinal Nerve Fiber Layer Progression in Glaucoma: A Study on Optical Coherence Tomography Guided Progression Analysis Free

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Christopher Kai-shun Leung; Carol Yim Lui Cheung; Robert N. Weinreb; Kunliang Qiu; Shu Liu; Haitao Li; Guihua Xu; Ning Fan; Chi Pui Pang; Kwok Kay Tse; Dennis Shun Chiu Lam

Tags: glaucoma, optical coherence tomography, retinal nerve fiber layer, trend

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 217-222. doi:https://doi.org/10.1167/iovs.09-3468

Inhibition of RhoA Signaling with Increased Bves in Trabecular Meshwork Cells Free

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Patricia K. Russ; Asher I. Kupperman; Sai-Han Presley; Frederick R. Haselton; Min S. Chang

Tags: rhoa gtp-binding protein, signal transduction, trabecular meshwork

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 223-230. doi:https://doi.org/10.1167/iovs.09-3539

The Effect of Trabeculectomy on Ocular Pulse Amplitude Free

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Christophe Breusegem; Steffen Fieuws; Thierry Zeyen; Ingeborg Stalmans

Tags: intraocular pressure, trabeculectomy, eye

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 231-235. doi:https://doi.org/10.1167/iovs.09-3712

Self-complementary AAV Virus (scAAV) Safe and Long-term Gene Transfer in the Trabecular Meshwork of Living Rats and Monkeys Free

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LaKisha K. Buie; Carol A. Rasmussen; Eric C. Porterfield; Vinod S. Ramgolam; Vivian W. Choi; Silva Markovic-Plese; Richard J. Samulski; Paul L. Kaufman; Teresa Borrás

Tags: cercopithecidae, rats, trabecular meshwork, viruses, gene transfer techniques

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 236-248. doi:https://doi.org/10.1167/iovs.09-3847

Heterozygous Loss-of-Function Variants in CYP1B1 Predispose to Primary Open-Angle Glaucoma Free

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Francesca Pasutto; Gabriela Chavarria-Soley; Christian Y. Mardin; Karin Michels-Rautenstrauss; Magnus Ingelman-Sundberg; Lorena Fernández-Martínez; Bernhard H. F. Weber; Bernd Rautenstrauss; André Reis

Tags: heterozygote, mutation, open-angle glaucoma

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 249-254. doi:https://doi.org/10.1167/iovs.09-3880

Functional and Structural Changes in a Canine Model of Hereditary Primary Angle-Closure Glaucoma Free

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Sinisa D. Grozdanic; Helga Kecova; Matthew M. Harper; Wijitha Nilaweera; Markus H. Kuehn; Randy H. Kardon

Tags: angle closure glaucoma, dog, domestic, electroretinography, glaucoma, intraocular pressure

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 255-263. doi:https://doi.org/10.1167/iovs.09-4081

Clinical Evaluation of the Proper Orthogonal Decomposition Framework for Detecting Glaucomatous Changes in Human Subjects Free

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Madhusudhanan Balasubramanian; Christopher Bowd; Robert N. Weinreb; Gianmarco Vizzeri; Luciana M. Alencar; Pamela A. Sample; Neil O'Leary; Linda M. Zangwill

Tags: antidepressive agents, tricyclic, glaucoma, trichloroacetic acid, follow-up, eye

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 264-271. doi:https://doi.org/10.1167/iovs.08-2014

Peripheral Vascular Endothelial Dysfunction in Glaucomatocyclitic Crisis: A Preliminary Study Free

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Su-Chin Shen; Wan-Jing Ho; Shiu-Chen Wu; Kuang-Hui Yu; Hsin-Chiung Lin; Yu-Sheng Lin; Pei-Kwei Tsay; Pao-Hsien Chu

Tags: endothelial dysfunction, endothelium, glaucomatocyclitic crisis, inflammation, antibodies

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 272-276. doi:https://doi.org/10.1167/iovs.09-3849

Involvement of Platelet Coagulation and Inflammation in the Endothelium of Schlemm's Canal Free

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Yukiko Watanabe; Teruhiko Hamanaka; Tamiko Takemura; Akira Murakami

Tags: antibodies, blood coagulation, blood platelets, endothelial cells, immunohistochemistry

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 277-283. doi:https://doi.org/10.1167/iovs.08-3279

ACS67, a Hydrogen Sulfide–Releasing Derivative of Latanoprost Acid, Attenuates Retinal Ischemia and Oxidative Stress to RGC-5 Cells in Culture Free

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Neville N. Osborne; Dan Ji; Aman S. Abdul Majid; Rebecca J. Fawcett; Anna Sparatore; Piero Del Soldato

Tags: hydrogen sulfide, ischemia, latanoprost, oxidative stress, physiologic reperfusion

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 284-294. doi:https://doi.org/10.1167/iovs.09-3999

Correlation between Local Stress and Strain and Lamina Cribrosa Connective Tissue Volume Fraction in Normal Monkey Eyes Free

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Michael D. Roberts; Yi Liang; Ian A. Sigal; Jonathan Grimm; Juan Reynaud; Anthony Bellezza; Claude F. Burgoyne; J. Crawford Downs

Tags: cercopithecidae, connective tissue, eye, sclera, stress

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 295-307. doi:https://doi.org/10.1167/iovs.09-4016

Ocular Gene Transfer of Active TGF-β Induces Changes in Anterior Segment Morphology and Elevated IOP in Rats Free

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Jennifer V. Robertson; Elizabeth Golesic; Jack Gauldie; Judith A. West-Mays

Tags: eye, gene transfer techniques, language morphology, morphology, raised intraocular pressure

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 308-318. doi:https://doi.org/10.1167/iovs.09-3380

Silent Substitution Stimulation of S-cone Pathway and L- and M-cone Pathway in Glaucoma Free

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Patrick Bessler; Sascha Klee; Ulrich Kellner; Jens Haueisen

Tags: glaucoma, retinal cone

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 319-326. doi:https://doi.org/10.1167/iovs.09-3467

Combined Application of BDNF to the Eye and Brain Enhances Ganglion Cell Survival and Function in the Cat after Optic Nerve Injury Free

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Arthur J. Weber; Suresh Viswanáthan; Chidambaram Ramanathan; Christine D. Harman

Tags: adaptive testing, brain, brain-derived neurotrophic factor, cats, cell survival

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 327-334. doi:https://doi.org/10.1167/iovs.09-3740

Cirrus High-Definition Optical Coherence Tomography Compared with Stratus Optical Coherence Tomography in Glaucoma Diagnosis Free

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Javier Moreno-Montañés; Natalia Olmo; Aurora Alvarez; Noelia García; Javier Zarranz-Ventura

Tags: glaucoma, optical coherence tomography, retinal nerve fiber layer, eye

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 335-343. doi:https://doi.org/10.1167/iovs.08-2988

Expression of Podoplanin and Other Lymphatic Markers in the Human Anterior Eye Segment Free

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Kerstin Birke; Elke Lütjen-Drecoll; Dontscho Kerjaschki; Marco T. Birke

Tags: anterior eyeball segment, body tissue, eye, immune reconstitution inflammatory syndrome, iris

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 344-354. doi:https://doi.org/10.1167/iovs.08-3307

Estimating Normative Limits of Heidelberg Retina Tomograph Optic Disc Rim Area with Quantile Regression Free

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Paul H. Artes; David P. Crabb

Tags: eye, glaucoma, heidelberg retina tomograph, magnetic resonance angiography, mineralocorticoid receptor antagonists

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 355-361. doi:https://doi.org/10.1167/iovs.08-3354

Immunology and Microbiology

Bacterial Susceptibility to Topical Antimicrobials and Clinical Outcome in Bacterial Keratitis Free

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Stephen Kaye; Stephen Tuft; Timothy Neal; Derek Tole; John Leeming; Francisco Figueiredo; Malcolm Armstrong; Peter McDonnell; Andrew Tullo; Christopher Parry

Tags: antimicrobials, bacterial keratitis, disease susceptibility, treatment outcome, keratitis

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 362-368. doi:https://doi.org/10.1167/iovs.09-3933

In Vivo Imaging of Ocular MCMV Infection Free

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Martin S. Zinkernagel; Claire Petitjean; Peter Fleming; Holly R. Chinnery; Ian J. Constable; Paul G. McMenamin; Mariapia A. Degli-Esposti

Tags: diagnostic imaging, infections, retina

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 369-374. doi:https://doi.org/10.1167/iovs.09-4083

Kininogen in Autoimmune Uveitis: Decrease in Peripheral Blood Stream versus Increase in Target Tissue Free

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Johanna K. Zipplies; Stefanie M. Hauck; Stephanie Schoeffmann; Barbara Amann; Christiaan H. van der Meijden; Manfred Stangassinger; Marius Ueffing; Cornelia A. Deeg

Tags: autoimmune diseases, autoimmunity, body tissue, proteins, uveitis

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 375-382. doi:https://doi.org/10.1167/iovs.09-4094

Contribution of CD4⁺CD25⁺ T Cells to the Regression Phase of Experimental Autoimmune Uveoretinitis Free

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Min Sun; Peizeng Yang; Liping Du; Hongyan Zhou; Xiangrong Ren; Aize Kijlstra

Tags: antigens, cd25, autoimmune diseases, t-lymphocytes, regulatory t-lymphocytes, mice

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 383-389. doi:https://doi.org/10.1167/iovs.09-3514

In Vivo Performance of Melimine as an Antimicrobial Coating for Contact Lenses in Models of CLARE and CLPU Free

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Nerida Cole; Emma B. H. Hume; Ajay K. Vijay; Padmaja Sankaridurg; Naresh Kumar; Mark D. P. Willcox

Tags: antimicrobials, contact lenses, lens (device), lens, crystalline, eye

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 390-395. doi:https://doi.org/10.1167/iovs.09-4068

Lens

Identification of Vimentin as a Novel Target of HSF4 in Lens Development and Cataract by Proteomic Analysis Free

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Lisha Mou; Jing-Ying Xu; Weiye Li; Xia Lei; Yalan Wu; Guoxu Xu; Xiangyin Kong; Guo-Tong Xu

Tags: cataract, lens (device), lens, crystalline, mice, vimentin

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 396-404. doi:https://doi.org/10.1167/iovs.09-3772

Physiology and Pharmacology

The Effects of a Flexible Visual Acuity–Driven Ranibizumab Treatment Regimen in Age-Related Macular Degeneration: Outcomes of a Drug and Disease Model Free

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Frank G. Holz; Jean-François Korobelnik; Paolo Lanzetta; Paul Mitchell; Ursula Schmidt-Erfurth; Sebastian Wolf; Sabri Markabi; Heinz Schmidli; Andreas Weichselberger

Tags: disease models, ranibizumab, treatment protocols, visual acuity, age-related macular degeneration

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 405-412. doi:https://doi.org/10.1167/iovs.09-3813

Identification of a Novel Sodium-Coupled Oligopeptide Transporter (SOPT2) in Mouse and Human Retinal Pigment Epithelial Cells Free

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Paresh P. Chothe; Santoshanand V. Thakkar; Jaya P. Gnana-Prakasam; Sudha Ananth; David R. Hinton; Ram Kannan; Sylvia B. Smith; Pamela M. Martin; Vadivel Ganapathy

Tags: enkephalin, leucine-2-alanine, membrane transport proteins, mice, oligopeptides, opioid peptide

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 413-420. doi:https://doi.org/10.1167/iovs.09-4048

The PI3K/Akt and mTOR/P70S6K Signaling Pathways in Human Uveal Melanoma Cells: Interaction with B-Raf/ERK Free

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Narjes Babchia; Armelle Calipel; Frédéric Mouriaux; Anne-Marie Faussat; Frédéric Mascarelli

Tags: 1-phosphatidylinositol 3-kinase, cell proliferation, mtor serine-threonine kinases, phosphoinositide 3-kinase, proto-oncogene proteins c-akt

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 421-429. doi:https://doi.org/10.1167/iovs.09-3974

Involvement of OCTN2 in the Transport of Acetyl-l-Carnitine across the Inner Blood–Retinal Barrier Free

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Masanori Tachikawa; Yoko Takeda; Masatoshi Tomi; Ken-ichi Hosoya

Tags: biological transport, carnitine, blood-retinal barrier, retina

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 430-436. doi:https://doi.org/10.1167/iovs.09-4080

Reduced Myocilin Expression in Cultured Monkey Trabecular Meshwork Cells Induced by a Selective Glucocorticoid Receptor Agonist: Comparison with Steroids Free

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Bruce A. Pfeffer; Charu A. DeWitt; Mercedes Salvador-Silva; Megan E. Cavet; Francisco J. López; Keith W. Ward

Tags: agonists, cercopithecidae, glucocorticoid receptors, myoc gene, proteins

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 437-446. doi:https://doi.org/10.1167/iovs.09-4202

Retina

The Structural Relationship between the Microvasculature, Neurons, and Glia in the Human Retina Free

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Paula K. Yu; Chandrakumar Balaratnasingam; William H. Morgan; Stephen J. Cringle; Ian L. McAllister; Dao-Yi Yu

Tags: donors, eye, microvascular network, neuroglia, neurons

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 447-458. doi:https://doi.org/10.1167/iovs.09-3978

Stimulation of Axon Regeneration in the Mature Optic Nerve by Intravitreal Application of the Toll-like Receptor 2 Agonist Pam₃Cys Free

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Thomas G. Hauk; Marco Leibinger; Adrienne Müller; Anastasia Andreadaki; Uwe Knippschild; Dietmar Fischer

Tags: agonists, axon, intravitreal injections, optic nerve, toll-like receptor 2

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 459-464. doi:https://doi.org/10.1167/iovs.09-4203

Three-Dimensional Profile of Macular Retinal Thickness in Normal Japanese Eyes Free

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Sotaro Ooto; Masanori Hangai; Atsushi Sakamoto; Atsuo Tomidokoro; Makoto Araie; Tomohiro Otani; Shoji Kishi; Kenji Matsushita; Naoyuki Maeda; Motohiro Shirakashi; Haruki Abe; Hisashi Takeda; Kazuhisa Sugiyama; Hitomi Saito; Aiko Iwase; Nagahisa Yoshimura

Tags: eye, japanese, diameter, diagnostic imaging, nose

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 465-473. doi:https://doi.org/10.1167/iovs.09-4047

Intravitreal Crystalline Drug Delivery for Intraocular Proliferation Diseases Free

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Lingyun Cheng; Karl Hostetler; Nadya Valiaeva; Ajay Tammewar; William R. Freeman; James Beadle; Dirk-Uwe Bartsch; Kathy Aldern; Iryna Falkenstein

Tags: cerebral palsy, ceruloplasmin, cleft palate, crystal structure, drug delivery systems

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 474-481. doi:https://doi.org/10.1167/iovs.09-3672

Correlation between Retinal Oscillatory Potentials and Retinal Vascular Caliber in Type 2 Diabetes Free

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Chi D. Luu; Joshua A. Szental; Shu-Yen Lee; Raghavan Lavanya; Tien Y. Wong

Tags: diabetes mellitus, type 2, retinal vascular caliber, electroretinography, nonproliferative diabetic retinopathy, diameter

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 482-486. doi:https://doi.org/10.1167/iovs.09-4069

Protection of the Retina by Rapid Diffusion of Hydrogen: Administration of Hydrogen-Loaded Eye Drops in Retinal Ischemia–Reperfusion Injury Free

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Hideaki Oharazawa; Tsutomu Igarashi; Takashi Yokota; Hiroaki Fujii; Hisaharu Suzuki; Mitsuru Machide; Hiroshi Takahashi; Shigeo Ohta; Ikuroh Ohsawa

Tags: eyedrops, retina, retinal ischemia, hydrogen, reperfusion injury

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 487-492. doi:https://doi.org/10.1167/iovs.09-4089

In Vivo Analysis of Cone Survival in Mice Free

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Susanne C. Beck; Karin Schaeferhoff; Stylianos Michalakis; M. Dominik Fischer; Gesine Huber; Norman Rieger; Olaf Riess; Bernd Wissinger; Martin Biel; Michael Bonin; Mathias W. Seeliger; Naoyuki Tanimoto

Tags: mice, retinal cone

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 493-497. doi:https://doi.org/10.1167/iovs.09-4003

Oscillation of Angiogenesis with Vascular Dropout in Diabetic Retinopathy by VESsel GENeration Analysis (VESGEN) Free

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Patricia Parsons-Wingerter; Krishnan Radhakrishnan; Mary B. Vickerman; Peter K. Kaiser

Tags: angiogenesis, blood vessels, diabetic retinopathy, nonproliferative diabetic retinopathy, trees (plant)

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 498-507. doi:https://doi.org/10.1167/iovs.09-3968

Retinal Cell Biology

Suppression of ICAM-1 in Retinal and Choroidal Endothelial Cells by Plasmid Small-Interfering RNAs In Vivo Free

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Yoshio Hirano; Eiji Sakurai; Akihisa Matsubara; Yuichiro Ogura

Tags: intercellular adhesion molecule 1, plasmids, rna, small interfering

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 508-515. doi:https://doi.org/10.1167/iovs.09-3457

Using neurogenin to Reprogram Chick RPE to Produce Photoreceptor-like Neurons Free

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Xiumei Li; Wenxin Ma; Yehong Zhuo; Run-Tao Yan; Shu-Zhen Wang

Tags: epithelium, photoreceptors, pigment, embryo, genes

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 516-525. doi:https://doi.org/10.1167/iovs.09-3822

Valproic Acid–Mediated Neuroprotection and Regeneration in Injured Retinal Ganglion Cells Free

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Julia Biermann; Philippe Grieshaber; Ulrich Goebel; Gottfried Martin; Solon Thanos; Simone Di Giovanni; Wolf Alexander Lagrèze

Tags: valproic acid

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 526-534. doi:https://doi.org/10.1167/iovs.09-3903

Inhibition of Protein Kinase C Is Not Sufficient to Prevent or Reverse Effects of VEGF₁₆₅ on Claudin-1 and Permeability in Microvascular Retinal Endothelial Cells Free

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Heidrun L. Deissler; Helmut Deissler; Gabriele E. Lang

Tags: endothelial cells, permeability, vascular endothelial growth factor a, protein kinase c, ranibizumab

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 535-542. doi:https://doi.org/10.1167/iovs.09-3917

Soluble EphB4 Inhibition of PDGF-Induced RPE Migration In Vitro Free

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Shikun He; S. Ram Kumar; Peng Zhou; Valery Krasnoperov; Stephen J. Ryan; Parkash S. Gill; David R. Hinton

Tags: platelet-derived growth factor, retinal pigment cell, phosphorylation, retinal pigment epithelium, mitogen-activated protein kinases

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 543-552. doi:https://doi.org/10.1167/iovs.09-3475

Apical-to-Basolateral Transcytosis of Photoreceptor Outer Segments Induced by Lipid Peroxidation Products in Human Retinal Pigment Epithelial Cells Free

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Tim U. Krohne; Frank G. Holz; Jürgen Kopitz

Tags: lipid peroxidation, photoreceptors, proteins, retinal pigment cell, transcytosis

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 553-560. doi:https://doi.org/10.1167/iovs.09-3755

Protective Effect of Clusterin from Oxidative Stress–Induced Apoptosis in Human Retinal Pigment Epithelial Cells Free

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Jeong Hun Kim; Jin Hyoung Kim; Hyoung Oh Jun; Young Suk Yu; Bon Hong Min; Kyu Hyung Park; Kyu-Won Kim

Tags: apoptosis, clusterin, oxidative stress, retinal pigment cell, caspase-3

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 561-566. doi:https://doi.org/10.1167/iovs.09-3774

Visual Neuroscience

Topical Mydriatics Affect Light-Evoked Retinal Responses in Anesthetized Mice Free

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Deb Kumar Mojumder; Theodore G. Wensel

Tags: electroretinography, mice, mydriatics, mydriasis

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 567-576. doi:https://doi.org/10.1167/iovs.09-4168

Flicker ERGs Representing Chromaticity and Luminance Signals Free

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Jan Kremers; Anderson Raiol Rodrigues; Luiz Carlos de Lima Silveira; Manoel da Silva Filho

Tags: luminance, photopsia, retinal cone

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 577-587. doi:https://doi.org/10.1167/iovs.09-3899

Visual Psychophysics and Physiological Optics

A New Interocular Suppression Technique for Measuring Sensory Eye Dominance Free

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Eunice Yang; Randolph Blake; James E. McDonald, II

Tags: eye, ocular dominance

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 588-593. doi:https://doi.org/10.1167/iovs.08-3076

Onset and Progression of With-the-Rule Astigmatism in Children with Infantile Nystagmus Syndrome Free

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Jingyun Wang; Lauren M. Wyatt; Joost Felius; David R. Stager, Jr; David R. Stager, Sr; Eileen E. Birch; Harold E. Bedell

Tags: albinism, astigmatism, child, pathologic nystagmus, syndrome

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 594-601. doi:https://doi.org/10.1167/iovs.09-3599

Dichoptic Multifocal Pupillography Reveals Afferent Visual Field Defects in Early Type 2 Diabetes Free

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Andrew Bell; Andrew C. James; Maria Kolic; Rohan W. Essex; Ted Maddess

Tags: diabetes mellitus, type 2, scotoma, visual field defects, eye

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 602-608. doi:https://doi.org/10.1167/iovs.09-3659

Optical Characterization of Bangerter Foils Free

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Guillermo M. Pérez; Steven M. Archer; Pablo Artal

Tags: optics, filters, amblyopia

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 609-613. doi:https://doi.org/10.1167/iovs.09-3726

Age-Related Changes in Accommodative Dynamics from Preschool to Adulthood Free

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Heather A. Anderson; Adrian Glasser; Ruth E. Manny; Karla K. Stuebing

Tags: adult, preschools, visual accommodation, velocity

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 614-622. doi:https://doi.org/10.1167/iovs.09-3653

Three-Dimensional Optokinetic Eye Movements in the C57BL/6J Mouse Free

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Bart van Alphen; Beerend H. J. Winkelman; Maarten A. Frens

Tags: eye movement, mice, mice, inbred c57bl, eye, pupil

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 623-630. doi:https://doi.org/10.1167/iovs.09-4072

Clinical Trials

Effects of Antioxidants (AREDS Medication) on Ocular Blood Flow and Endothelial Function in an Endotoxin-Induced Model of Oxidative Stress in Humans Free

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Berthold Pemp; Elzbieta Polska; Katharina Karl; Michael Lasta; Alexander Minichmayr; Gerhard Garhofer; Michael Wolzt; Leopold Schmetterer

Tags: antioxidants, endothelium, endotoxins, oxidative stress, pharmaceutical preparations

Investigative Ophthalmology & Visual Science January 2010, Vol.51, 2-6. doi:https://doi.org/10.1167/iovs.09-3888

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