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Anatomy and Pathology/Oncology

Bevacizumab Suppression of Establishment of Micrometastases in Experimental Ocular Melanoma Free
PDF
Hua Yang; Martine J. Jager; Hans E. Grossniklaus
Tags: bevacizumab, eye melanomas, micrometastasis, uveal melanoma, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 2835-2842. doi:https://doi.org/10.1167/iovs.09-4755

Biochemistry and Molecular Biology

Detection and Quantification of Tear Phospholipids and Cholesterol in Contact Lens Deposits: The Effect of Contact Lens Material and Lens Care Solution Free
PDF
Jennifer T. Saville; Zhenjun Zhao; Mark D. P. Willcox; Stephen J. Blanksby; Todd W. Mitchell
Tags: cholesterol, contact lenses, lens (device), lens, crystalline, lipids
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 2843-2851. doi:https://doi.org/10.1167/iovs.09-4609
Mutation Discovered in a Feline Model of Human Congenital Retinal Blinding Disease Free
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Marilyn Menotti-Raymond; Koren Holland Deckman; Victor David; Jaimie Myrkalo; Stephen J. O'Brien; Kristina Narfström
Tags: cats, mutation, adaptive testing, genes
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 2852-2859. doi:https://doi.org/10.1167/iovs.09-4261
Gelatinase Expression in Retinoblastoma: Modulation of LHBETATAG Retinal Tumor Development by Anecortave Acetate Free
PDF
M. Livia Bajenaru; Yolanda Piña; Timothy G. Murray; Colleen M. Cebulla; William Feuer; Maria-Elena Jockovich; Maria-Encarna Marin Castaño
Tags: anecortave, gelatinases, neoplasms, retinal neoplasms, retinoblastoma
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 2860-2864. doi:https://doi.org/10.1167/iovs.09-4500
Inhibition of Matrix Metalloproteinase Activity in the Chick Sclera and Its Effect on Myopia Development Free
PDF
Hsin-Hua Liu; Alex Gentle; Andrew I. Jobling; Neville A. McBrien
Tags: catabolism, collagen, matrix metalloproteinases, myopia, sclera
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 2865-2871. doi:https://doi.org/10.1167/iovs.09-4322

Clinical and Epidemiologic Research

Blood Pressure, Perfusion Pressure, and Open-Angle Glaucoma: The Los Angeles Latino Eye Study Free
PDF
Farnaz Memarzadeh; Mei Ying-Lai; Jessica Chung; Stanley P. Azen; Rohit Varma; Los Angeles Latino Eye Study Group
Tags: blood pressure, eye, hispanics or latinos, open-angle glaucoma, perfusion
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 2872-2877. doi:https://doi.org/10.1167/iovs.08-2956
The Psychometric Validity of the NEI VFQ-25 for Use in a Low-Vision Population Free
PDF
Manjula Marella; Konrad Pesudovs; Jill E. Keeffe; Patricia M. O'Connor; Gwyneth Rees; Ecosse L. Lamoureux
Tags: psychometrics, rasch model, validity of results, visual impairment, weight measurement scales
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 2878-2884. doi:https://doi.org/10.1167/iovs.09-4494
Profile of Refractive Errors in Cerebral Palsy: Impact of Severity of Motor Impairment (GMFCS) and CP Subtype on Refractive Outcome Free
PDF
Kathryn J. Saunders; Julie-Anne Little; Julie F. McClelland; A. Jonathan Jackson
Tags: motor deficits, refractive errors, cerebral palsy
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 2885-2890. doi:https://doi.org/10.1167/iovs.09-4670
Vision-Specific Distress and Depressive Symptoms in People with Vision Impairment Free
PDF
Gwyneth Rees; Hui Wen Tee; Manjula Marella; Eva Fenwick; Mohamed Dirani; Ecosse L. Lamoureux
Tags: depressive disorders, vision, visual impairment
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 2891-2896. doi:https://doi.org/10.1167/iovs.09-5080
Dietary Carbohydrate in Relation to Cortical and Nuclear Lens Opacities in the Melbourne Visual Impairment Project Free
PDF
Chung-Jung Chiu; Luba Robman; Catherine Anne McCarty; Bickol Nanjan Mukesh; Allison Hodge; Hugh Ringland Taylor; Allen Taylor
Tags: carbohydrates, cataract, dietary carbohydrates, visual impairment, cortical cataract
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 2897-2905. doi:https://doi.org/10.1167/iovs.08-2824
The Relationship between Demodex and Ocular Discomfort Free
PDF
Seok Hyun Lee; Yeoun Sook Chun; Jae Hoon Kim; Eung Suk Kim; Jae Chan Kim
Tags: bacteria, eye, eye manifestations, eyelid, prevalence
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 2906-2911. doi:https://doi.org/10.1167/iovs.09-4850

Cornea

Biomechanical Properties of Keratoconus Suspect Eyes Free
PDF
Alain Saad; Yara Lteif; Elodie Azan; Damien Gatinel
Tags: eye, keratoconus
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 2912-2916. doi:https://doi.org/10.1167/iovs.09-4304
Responses of Cultured Human Keratocytes and Myofibroblasts to Ethyl Pyruvate: A Microarray Analysis of Gene Expression Free
PDF
Stephen A. K. Harvey; Emily Guerriero; Nahthai Charukamnoetkanok; Jordan Piluek; Joel S. Schuman; Nirmala SundarRaj
Tags: genes, keratocytes, myofibroblasts, pyruvates, gene expression
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 2917-2927. doi:https://doi.org/10.1167/iovs.09-4498
Glucose-6-phosphate-dehydrogenase Deficiency as a Risk Factor for Pterygium Free
PDF
Enrico Peiretti; Antonella Mandas; Pierluigi Cocco; Claudia Norfo; Claudia Abete; Fabrizio Angius; Alessandra Pani; Sarah Vascellari; Guido Del Fiacco; Dolores Cannas; Giacomo Diaz; Sandra Dessì; Maurizio Fossarello
Tags: glucosephosphate dehydrogenase, pterygium, risk factors, lipids, oxidative stress
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 2928-2935. doi:https://doi.org/10.1167/iovs.09-4426
Changes in Corneal Collagen Architecture during Mouse Postnatal Development Free
PDF
Jack Sheppard; Sally Hayes; Craig Boote; Marcela Votruba; Keith M. Meek
Tags: collagen, cornea, diagnostic radiologic examination, mice, roentgen rays
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 2936-2942. doi:https://doi.org/10.1167/iovs.09-4612
Effect of EGF-Induced HDAC6 Activation on Corneal Epithelial Wound Healing Free
PDF
Jie Wang; Andrew Lin; Luo Lu
Tags: cell motility, cornea, epithelium, tubulin, wound healing
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 2943-2948. doi:https://doi.org/10.1167/iovs.09-4639
Enzymatic Quantification of Cholesterol and Cholesterol Esters from Silicone Hydrogel Contact Lenses Free
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Andrew D. Pucker; Mirunalni Thangavelu; Jason J. Nichols
Tags: cholesterol, cholesterol esters, contact lenses, hydrogel, lens (device)
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 2949-2954. doi:https://doi.org/10.1167/iovs.08-3368
Release of Interleukins 6 and 8 Induced by Zymosan and Mediated by MAP Kinase and NF-κB Signaling Pathways in Human Corneal Fibroblasts Free
PDF
Norimasa Nomi; Kazuhiro Kimura; Teruo Nishida
Tags: cornea, fibroblasts, interleukin-6, interleukin-8, interleukins
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 2955-2959. doi:https://doi.org/10.1167/iovs.09-4823
Duct System of the Rabbit Lacrimal Gland: Structural Characteristics and Role in Lacrimal Secretion Free
PDF
Chuanqing Ding; Leili Parsa; Prachi Nandoskar; Ping Zhao; Kaijin Wu; Yanru Wang
Tags: bodily secretions, fluorescent antibody technique, lacrimal gland, oryctolagus cuniculus, reverse transcriptase polymerase chain reaction
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 2960-2967. doi:https://doi.org/10.1167/iovs.09-4687

Glaucoma

Protein Macroarray Profiling of Serum Autoantibodies in Pseudoexfoliation Glaucoma Free
PDF
Edward W. Dervan; Hong Chen; Su Ling Ho; Nikola Brummel; Jasmin Schmid; David Toomey; Margarita Haralambova; Edith Gould; Deborah M. Wallace; Jochen H. M. Prehn; Colm J. O'Brien; Derek Murphy
Tags: autoantibodies, exfoliation syndrome, proteins, antigens, dna, complementary
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 2968-2975. doi:https://doi.org/10.1167/iovs.09-4898
Modulation of Inflammatory Markers by miR-146a during Replicative Senescence in Trabecular Meshwork Cells Free
PDF
Guorong Li; Coralia Luna; Jianming Qiu; David L. Epstein; Pedro Gonzalez
Tags: cellular senescence, inflammatory markers, micrornas, plasminogen activator inhibitor 1, trabecular meshwork
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 2976-2985. doi:https://doi.org/10.1167/iovs.09-4874
Neuroprotective Effect of Upregulated Sonic Hedgehog in Retinal Ganglion Cells Following Chronic Ocular Hypertension Free
PDF
Jihong Wu; Shenghai Zhang; Xinghuai Sun
Tags: neuroprotective effect, ocular hypertension, retinal ganglion cells, shh gene
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 2986-2992. doi:https://doi.org/10.1167/iovs.09-4151
Use of EyeCam for Imaging the Anterior Chamber Angle Free
PDF
Shamira A. Perera; Mani Baskaran; David S. Friedman; Tin A. Tun; Hla M. Htoon; Rajesh S. Kumar; Tin Aung
Tags: anterior chamber of eye, diagnostic imaging, gonioscopy, eye
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 2993-2997. doi:https://doi.org/10.1167/iovs.09-4418
Influence of Height, Weight, and Body Mass Index on Optic Disc Parameters Free
PDF
Yingfeng Zheng; Carol Y. L. Cheung; Tien Y. Wong; Paul Mitchell; Tin Aung
Tags: body mass index procedure, body weight, optic disk, weight (force)
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 2998-3002. doi:https://doi.org/10.1167/iovs.09-4470
Retinal Cell Responses to Elevated Intraocular Pressure: A Gene Array Comparison between the Whole Retina and Retinal Ganglion Cell Layer Free
PDF
Ying Guo; William O. Cepurna; Jennifer A. Dyck; Tom A. Doser; Elaine C. Johnson; John C. Morrison
Tags: genes, glaucoma, raised intraocular pressure, retina, retinal ganglion cells
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3003-3018. doi:https://doi.org/10.1167/iovs.09-4663
Time-Dependent Effects of Focal Retinal Ischemia on Axonal Cytoskeleton Proteins Free
PDF
Chandrakumar Balaratnasingam; William H. Morgan; Louise Bass; Min Kang; Stephen J. Cringle; Dao-Yi Yu
Tags: cytoskeleton, did not receive therapy or drug, ischemia, proteins, retinal ischemia
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3019-3028. doi:https://doi.org/10.1167/iovs.09-4692
Development of a Gene Therapy Virus with a Glucocorticoid-Inducible MMP1 for the Treatment of Steroid Glaucoma Free
PDF
Maria-Grazia Spiga; Teresa Borrás
Tags: glucocorticoids, interstitial collagenase, steroids, viruses
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3029-3041. doi:https://doi.org/10.1167/iovs.09-4918
Treatment of Sheep Steroid–Induced Ocular Hypertension with a Glucocorticoid-Inducible MMP1 Gene Therapy Virus Free
PDF
Rosana Gerometta; Maria-Grazia Spiga; Teresa Borrás; Oscar A. Candia
Tags: glucocorticoids, interstitial collagenase, ocular hypertension, sheep, steroids
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3042-3048. doi:https://doi.org/10.1167/iovs.09-4920
Calpain Activation in Experimental Glaucoma Free
PDF
Wei Huang; John Fileta; Ian Rawe; Juan Qu; Cynthia L. Grosskreutz
Tags: calpain, cytokinesis, glaucoma, raised intraocular pressure, calcineurin
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3049-3054. doi:https://doi.org/10.1167/iovs.09-4364
Association of POAG Risk Factors and the Thr377Met MYOC Mutation in an Isolated Greek Population Free
PDF
Mary K. Wirtz; John R. Samples; Victoria Toumanidou; Jac Charlesworth; Dimitrios G. Mikropoulos; Konstantinos Kaltsos; Athanasios Economou; Antonios Dimopoulos; Irene N. Georgiadou; Georgios Moumtzis; Athanasios Papanastasiou; Patricia L. Kramer; Tom Dyer; John Blangero; Anastasios G. P. Konstas
Tags: mutation, myoc gene, open-angle glaucoma, risk factors, greek
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3055-3060. doi:https://doi.org/10.1167/iovs.09-4652

Immunology and Microbiology

Antifibrotic Effect of Pirfenidone on Orbital Fibroblasts of Patients with Thyroid-Associated Ophthalmopathy by Decreasing TIMP-1 and Collagen Levels Free
PDF
Hyunmi Kim; Youn-Hee Choi; Soo Jung Park; Sang Yeul Lee; Sung Joo Kim; Ilo Jou; Koung Hoon Kook
Tags: fibroblasts, graves' ophthalmopathy, pirfenidone, tissue-inhibitor of metalloproteinase-1, collagen
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3061-3066. doi:https://doi.org/10.1167/iovs.09-4257
Immune Responses to Interphotoreceptor Retinoid-Binding Protein and S-Antigen in Behçet's Patients with Uveitis Free
PDF
Masaru Takeuchi; Yoshihiko Usui; Yoko Okunuki; Lina Zhang; Juan Ma; Naoyuki Yamakawa; Takaaki Hattori; Takeshi Kezuka; Jun-ichi Sakai; Hiroshi Goto
Tags: antigens, behcet syndrome, cytokine, immune response, uveitis
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3067-3075. doi:https://doi.org/10.1167/iovs.09-4313
TSLP and Downstream Molecules in Experimental Mouse Allergic Conjunctivitis Free
PDF
Xiaofen Zheng; Ping Ma; Cintia S. de Paiva; Matthew A. Cunningham; Cindy S. Hwang; Stephen C. Pflugfelder; De-Quan Li
Tags: allergic conjunctivitis, mice, thymic stromal lymphopoietin, molecule, dendritic cells
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3076-3082. doi:https://doi.org/10.1167/iovs.09-4122
Desiccating Stress Promotion of Th17 Differentiation by Ocular Surface Tissues through a Dendritic Cell-Mediated Pathway Free
PDF
Xiaofen Zheng; Cintia S. de Paiva; De-Quan Li; William J. Farley; Stephen C. Pflugfelder
Tags: body tissue, conjunctiva, cornea, cytokine, dendrites
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3083-3091. doi:https://doi.org/10.1167/iovs.09-3838
The Role of TLR2, TRL3, TRL4, and TRL9 Signaling in the Pathogenesis of Autoimmune Disease in a Retinal Autoimmunity Model Free
PDF
Jiazhu Fang; Dan Fang; Phyllis B. Silver; Feng Wen; Bing Li; Xiangrong Ren; Qing Lin; Rachel R. Caspi; Shao Bo Su
Tags: autoimmune diseases, autoimmunity, immunization, mice, pathogenesis
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3092-3099. doi:https://doi.org/10.1167/iovs.09-4754
The Impact of Inoculation Parameters on the Pathogenesis of Contact Lens–Related Infectious Keratitis Free
PDF
Connie Tam; James J. Mun; David J. Evans; Suzanne M. J. Fleiszig
Tags: contact lenses, cornea, keratitis, lens (device), lens, crystalline
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3100-3106. doi:https://doi.org/10.1167/iovs.09-4593

Lens

Age-Dependent Deamidation of Lifelong Proteins in the Human Lens Free
PDF
Peter G. Hains; Roger J. W. Truscott
Tags: crystallins, lens, crystalline, proteins, lens (device)
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3107-3114. doi:https://doi.org/10.1167/iovs.09-4308

Physiology and Pharmacology

The Safety of Intraocular Linezolid in Rabbits Free
PDF
Sara L. Duke; Leila I. Kump; Yang Yuan; William W. West; Andrew J. Sachs; Neena B. Haider; Eyal Margalit
Tags: linezolid, oryctolagus cuniculus, safety, eye
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3115-3119. doi:https://doi.org/10.1167/iovs.09-4244
An In Vitro Intact Globe Expansion Method for Evaluation of Cross-linking Treatments Free
PDF
Matthew S. Mattson; Joyce Huynh; Meredith Wiseman; Marco Coassin; Julia A. Kornfield; Daniel M. Schwartz
Tags: cornea, eye, cross-linking, riboflavin, sclera
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3120-3128. doi:https://doi.org/10.1167/iovs.09-4001
Hydrostatic Pressure–Induced Release of Stored Calcium in Cultured Rat Optic Nerve Head Astrocytes Free
PDF
Amritlal Mandal; Mohammad Shahidullah; Nicholas A. Delamere
Tags: calcium, hydrostatic pressure, astrocytes, optic disk
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3129-3138. doi:https://doi.org/10.1167/iovs.09-4614
Effects of Sildenafil and Tadalafil on Intraocular Pressure in Sheep: Implications for Aqueous Humor Dynamics Free
PDF
Rosana Gerometta; Lawrence J. Alvarez; Oscar A. Candia
Tags: intraocular pressure, sheep, sildenafil, tadalafil, aqueous humor
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3139-3144. doi:https://doi.org/10.1167/iovs.09-4862
Aqueous Humor Dynamics during the Day and Night in Juvenile and Adult Rabbits Free
PDF
Min Zhao; Joseph J. Hejkal; Carl B. Camras; Carol B. Toris
Tags: adult, aqueous humor, child, intraocular pressure, oryctolagus cuniculus
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3145-3151. doi:https://doi.org/10.1167/iovs.09-4415

Retina

Comparison between Macular Pigment Optical Density Measurements Using Two-Wavelength Autofluorescence and Heterochromatic Flicker Photometry Techniques Free
PDF
Renata Canovas; Verônica Castro Lima; Patricia Garcia; Chiara Morini; Tiago S. Prata; Richard B. Rosen
Tags: autofluorescence, optics, photometry, photopsia, pigment
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3152-3156. doi:https://doi.org/10.1167/iovs.09-3608
Aqueous Humor Levels of Hepatocyte Growth Factor in Retinitis Pigmentosa Free
PDF
David Salom; Manuel Diaz-Llopis; Arturo Quijada; Salvador García-Delpech; Patricia Udaondo; F. Javier Romero; Jose Maria Millan; J. Fernando Arevalo
Tags: aqueous humor, hepatocyte growth factor, retinitis pigmentosa
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3157-3161. doi:https://doi.org/10.1167/iovs.09-4390
Physicochemical Properties Affecting Retinal Drug/Coumarin-6 Delivery from Nanocarrier Systems via Eyedrop Administration Free
PDF
Yuta Inokuchi; Kohei Hironaka; Takuya Fujisawa; Yuichi Tozuka; Kazuhiro Tsuruma; Masamitsu Shimazawa; Hirofumi Takeuchi; Hideaki Hara
Tags: coumarins, eyedrops, fluorescence, liposomes, retina
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3162-3170. doi:https://doi.org/10.1167/iovs.09-4697
Automated Quantification and Topographical Distribution of the Whole Population of S- and L-Cones in Adult Albino and Pigmented Rats Free
PDF
Arturo Ortín-Martínez; Manuel Jiménez-López; Francisco M. Nadal-Nicolás; Manuel Salinas-Navarro; Luis Alarcón-Martínez; Yves Sauvé; Maria Paz Villegas-Pérez; Manuel Vidal-Sanz; Marta Agudo-Barriuso
Tags: retinal cone, retina, albinism, rats
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3171-3183. doi:https://doi.org/10.1167/iovs.09-4861
Monoscopic versus Stereoscopic Retinal Photography for Grading Diabetic Retinopathy Severity Free
PDF
Helen K. Li; Larry D. Hubbard; Ronald P. Danis; Adol Esquivel; Jose F. Florez-Arango; Elizabeth A. Krupinski
Tags: diabetic retinopathy, eye, photography
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3184-3192. doi:https://doi.org/10.1167/iovs.09-4886
Effect of Robo1 on Retinal Pigment Epithelial Cells and Experimental Proliferative Vitreoretinopathy Free
PDF
Lvzhen Huang; Yongsheng Xu; Wenzhen Yu; Yingjie Li; Liqun Chu; Jianqiang Dong; Xiaoxin Li
Tags: retinal pigment cell, rna, small interfering, vitreoretinopathy, proliferative, transfection
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3193-3204. doi:https://doi.org/10.1167/iovs.09-3779
Prevalence and Systemic Risk Factors for Retinal Vein Occlusion in a General Japanese Population: The Hisayama Study Free
PDF
Miho Yasuda; Yutaka Kiyohara; Satoshi Arakawa; Yasuaki Hata; Koji Yonemoto; Yasufumi Doi; Mitsuo Iida; Tatsuro Ishibashi
Tags: hematocrit, hypertension, japanese, prevalence, retinal vein occlusion
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3205-3209. doi:https://doi.org/10.1167/iovs.09-4453
Retinal Adaptability Loss in Serous Retinal Detachment with Central Serous Chorioretinopathy Free
PDF
Yoshiaki Shimada; Daisuke Imai; Yuriko Ota; Kaname Kanai; Keisuke Mori; Koichiro Murayama; Shin Yoneya
Tags: adaptability, central serous chorioretinopathy, exudative retinal detachment, eye, synthetic cannabinoids
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3210-3215. doi:https://doi.org/10.1167/iovs.09-4637

Retinal Cell Biology

Minimal Effects of VEGF and Anti-VEGF Drugs on the Permeability or Selectivity of RPE Tight Junctions Free
PDF
Shaomin Peng; Ron A. Adelman; Lawrence J. Rizzolo
Tags: tight junctions, vascular endothelial growth factor a, anti-vascular endothelial growth factor therapy, permeability
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3216-3225. doi:https://doi.org/10.1167/iovs.09-4162
Molecular and Biochemical Characterization of Folate Transport Proteins in Retinal Müller Cells Free
PDF
B. Renee Bozard; Preethi S. Ganapathy; Jennifer Duplantier; Barbara Mysona; Yonju Ha; Penny Roon; Robert Smith; I. David Goldman; Puttur Prasad; Pamela M. Martin; Vadivel Ganapathy; Sylvia B. Smith
Tags: carrier proteins, folic acid, mice, proteins, slc46a1 gene
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3226-3235. doi:https://doi.org/10.1167/iovs.09-4833
Involvement of P2X7 Receptors in the Hypoxia-Induced Death of Rat Retinal Neurons Free
PDF
Tetsuya Sugiyama; Hidehiro Oku; Maho Shibata; Masayuki Fukuhara; Hideyo Yoshida; Tsunehiko Ikeda
Tags: hypoxia, neurons, antagonists
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3236-3243. doi:https://doi.org/10.1167/iovs.09-4192
The Zebrafish Galectin Drgal1-L2 Is Expressed by Proliferating Müller Glia and Photoreceptor Progenitors and Regulates the Regeneration of Rod Photoreceptors Free
PDF
Sonya E. L. Craig; Ryan Thummel; Hafiz Ahmed; Gerardo R. Vasta; David R. Hyde; Peter F. Hitchcock
Tags: neuroglia, photoreceptors, proteins, rod photoreceptors, second language
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3244-3252. doi:https://doi.org/10.1167/iovs.09-4879
Inhibition of Cytokine Signaling in Human Retinal Endothelial Cells through Downregulation of Sphingomyelinases by Docosahexaenoic Acid Free
PDF
Madalina Opreanu; Todd A. Lydic; Gavin E. Reid; Kelly M. McSorley; Walter J. Esselman; Julia V. Busik
Tags: cytokine, docosahexaenoic acids, endothelial cells, signal transduction, down-regulation
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3253-3263. doi:https://doi.org/10.1167/iovs.09-4731
Photoreceptor Degeneration, Azoospermia, Leukoencephalopathy, and Abnormal RPE Cell Function in Mice Expressing an Early Stop Mutation in CLCN2 Free
PDF
Malia M. Edwards; Caralina Marín de Evsikova; Gayle B. Collin; Elaine Gifford; Jiang Wu; Wanda L. Hicks; Carrie Whiting; Nicholas H. Varvel; Nicole Maphis; Bruce T. Lamb; Jürgen K. Naggert; Patsy M. Nishina; Neal S. Peachey
Tags: azoospermia, homozygote, leukoencephalopathies, mice, mutation
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3264-3272. doi:https://doi.org/10.1167/iovs.09-4887
Antipermeability Function of PEDF Involves Blockade of the MAP Kinase/GSK/β-Catenin Signaling Pathway and uPAR Expression Free
PDF
Jinling Yang; Elia J. Duh; Ruth B. Caldwell; M. Ali Behzadian
Tags: mitogen-activated protein kinases, signal pathway, signal transduction pathways, urokinase plasminogen activator receptor, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3273-3280. doi:https://doi.org/10.1167/iovs.08-2878
Retinoic Acid Receptor (RAR)-α Is Not Critically Required for Mediating Retinoic Acid Effects in the Developing Mouse Retina Free
PDF
Laura Cammas; Frédéric Trensz; Abdeljalil Jellali; Norbert B. Ghyselinck; Michel J. Roux; Pascal Dollé
Tags: eye, mice, neural retina, retina, retinoic acid receptor
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3281-3290. doi:https://doi.org/10.1167/iovs.09-3769
Reduced Nitro-oxidative Stress and Neural Cell Death Suggests a Protective Role for Microglial Cells in TNFα−/− Mice in Ischemic Retinopathy Free
PDF
Laura Stevenson; Nuria Matesanz; Liza Colhoun; Kevin Edgar; Adrian Devine; Tom A. Gardiner; Denise M. McDonald
Tags: ischemia, mice, retina, retinal diseases, microglia
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3291-3299. doi:https://doi.org/10.1167/iovs.09-4344

Visual Neuroscience

The Mouse Model of Down Syndrome Ts65Dn Presents Visual Deficits as Assessed by Pattern Visual Evoked Potentials Free
PDF
Jonah Jacob Scott-McKean; Bo Chang; Ronald E. Hurd; Steven Nusinowitz; Cecilia Schmidt; Muriel T. Davisson; Alberto C. S. Costa
Tags: down syndrome, evoked potentials, visual, mice, electroretinography
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3300-3308. doi:https://doi.org/10.1167/iovs.09-4465

Visual Psychophysics and Physiological Optics

The Sensitivity of the 2- to 4-Month-Old Human Infant Accommodation System Free
PDF
Jingyun Wang; T. Rowan Candy
Tags: infant, visual accommodation, adult
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3309-3317. doi:https://doi.org/10.1167/iovs.09-4667
Measurement of the Time Course of Optical Quality and Visual Deterioration during Tear Break-Up Free
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Haixia Liu; Larry Thibos; Carolyn G. Begley; Arthur Bradley
Tags: optics, time factors, tear film finding, contact lenses
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 3318-3326. doi:https://doi.org/10.1167/iovs.09-4831

Clinical Trials

Blood–Retinal Barrier Glycerol Permeability in Diabetic Macular Edema and Healthy Eyes: Estimations from Macular Volume Changes after Peroral Glycerol Free
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Dorte Nellemann Thornit; Carl Martin Vinten; Birgit Sander; Henrik Lund-Andersen; Morten la Cour
Tags: diabetes mellitus, diabetic macular edema, glycerol, permeability, volume
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 2827-2834. doi:https://doi.org/10.1167/iovs.09-4172

Review

The Mouse Retina as an Angiogenesis Model Free
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Andreas Stahl; Kip M. Connor; Przemyslaw Sapieha; Jing Chen; Roberta J. Dennison; Nathan M. Krah; Molly R. Seaward; Keirnan L. Willett; Christopher M. Aderman; Karen I. Guerin; Jing Hua; Chatarina Löfqvist; Ann Hellström; Lois E. H. Smith
Tags: angiogenesis, mice, retina, neovascularization, pathologic
Investigative Ophthalmology & Visual Science June 2010, Vol.51, 2813-2826. doi:https://doi.org/10.1167/iovs.10-5176
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