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Biochemistry and Molecular Biology

Extracellular Matrix Elasticity Modulates TGF-β–Induced p38 Activation and Myofibroblast Transdifferentiation in Human Tenon Fibroblasts Free
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Tobias Meyer-ter-Vehn; Hong Han; Franz Grehn; Günther Schlunck
Tags: cell transdifferentiation, collagen, elasticity, extracellular matrix, fibroblasts
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9149-9155. doi:https://doi.org/10.1167/iovs.10-6679
Analysis and Comparison of Proteomic Profiles of Tear Fluid from Human, Cow, Sheep, and Camel Eyes Free
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Farrukh A. Shamsi; Ziyan Chen; Jingwen Liang; Kaijun Li; Ali A. Al-Rajhi; Imtiaz A. Chaudhry; Mingtao Li; Kaili Wu
Tags: camels, cattle, eye, gel, proteins
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9156-9165. doi:https://doi.org/10.1167/iovs.11-8301

Clinical and Epidemiologic Research

Quantitative Evaluation of Changes in Eyeball Shape in Emmetropization and Myopic Changes Based on Elliptic Fourier Descriptors Free
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Kotaro Ishii; Hiroyoshi Iwata; Tetsuro Oshika
Tags: eye, magnetic resonance imaging
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8585-8591. doi:https://doi.org/10.1167/iovs.11-7221
Long-Term Follow-Up of the Human Phenotype in Three Siblings with Cone Dystrophy Associated with a Homozygous p.G461R Mutation of KCNV2 Free
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Christoph Friedburg; Bernd Wissinger; Maria Schambeck; Michael Bonin; Susanne Kohl; Birgit Lorenz
Tags: cone dystrophy, electroretinography, follow-up, homozygote, mutation
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8621-8629. doi:https://doi.org/10.1167/iovs.11-8187
Rasch Analysis of the Ocular Surface Disease Index (OSDI) Free
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Bradley E. Dougherty; Jason J. Nichols; Kelly K. Nichols
Tags: dry eye syndromes, rasch model, surveys
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8630-8635. doi:https://doi.org/10.1167/iovs.11-8027
Prevalence and Characteristics of Primary Angle-Closure Diseases in a Rural Adult Chinese Population: The Handan Eye Study Free
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Yuanbo Liang; David S. Friedman; Qiang Zhou; Xiao Hui Yang; Lan Ping Sun; Lixia Guo; Dolly S. Chang; Liying Lian; Ning Li Wang; for the Handan Eye Study Group
Tags: adult, chinese people, eye, glaucoma, prevalence
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8672-8679. doi:https://doi.org/10.1167/iovs.11-7480
Independent Impact of Area-Level Socioeconomic Measures on Visual Impairment Free
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Yingfeng Zheng; Ecosse Lamoureux; Eric Finkelstein; Renyi Wu; Raghavan Lavanya; Daniel Chua; Tin Aung; Seang-Mei Saw; Tien Y. Wong
Tags: socioeconomic factors, visual impairment
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8799-8805. doi:https://doi.org/10.1167/iovs.11-7700
Can Clinical Signs of Trachoma Be Used after Multiple Rounds of Mass Antibiotic Treatment to Indicate Infection? Free
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Beatriz Munoz; Dianne Stare; Harran Mkocha; Charlotte Gaydos; Thomas Quinn; Sheila K. West
Tags: antibiotics, infections, participation in ward rounds, trachoma, community
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8806-8810. doi:https://doi.org/10.1167/iovs.11-8074
Variations in Eye Volume, Surface Area, and Shape with Refractive Error in Young Children by Magnetic Resonance Imaging Analysis Free
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Laurence S. Lim; Xianfeng Yang; Gus Gazzard; Xiaoyu Lin; Chelvin Sng; Seang-Mei Saw; Anqi Qiu
Tags: child, eye, magnetic resonance imaging, refractive errors, volume
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8878-8883. doi:https://doi.org/10.1167/iovs.11-7269
Validation and Reliability of the VF-14 Questionnaire in a German Population Free
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Peggy Pei-Chia Chiang; Eva Fenwick; Manjula Marella; Robert Finger; Ecosse Lamoureux
Tags: german, questionnaires, reliability, visual impairment, vision
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8919-8926. doi:https://doi.org/10.1167/iovs.11-7702
Phenotypic and Genotypic Characterization of Coagulase Negative Staphylococci (CoNS) Other than Staphylococcus epidermidis Isolated from Ocular Infections Free
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Abhijith R Makki; Savitri Sharma; Aparna Duggirala; K. Prashanth; Prashant Garg; Taraprasad Das
Tags: coagulase, eye infections, genotype, phenotype, staphylococcus
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9018-9022. doi:https://doi.org/10.1167/iovs.11-7777
Associations between Genetic Polymorphisms of Insulin-like Growth Factor Axis Genes and Risk for Age-Related Macular Degeneration Free
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Chung-Jung Chiu; Yvette P. Conley; Michael B. Gorin; Gary Gensler; Chao-Qiang Lai; Fu Shang; Allen Taylor
Tags: age-related macular degeneration, genes, insulin-like growth factor i, insulin-like-growth factor i receptor, polymorphism
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9099-9107. doi:https://doi.org/10.1167/iovs.11-7782
Association between Ocular Dominance and Spherical/Astigmatic Anisometropia, Age, and Sex: Analysis of 10,264 Myopic Individuals Free
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Stephan J. Linke; Julio Baviera; Gur Munzer; Johannes Steinberg; Gisbert Richard; Toam Katz
Tags: anisometropia, eye, ocular dominance, astigmatism
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9166-9173. doi:https://doi.org/10.1167/iovs.11-8131

Cornea

Neurotransmitter Influence on Human Meibomian Gland Epithelial Cells Free
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Wendy R. Kam; David A. Sullivan
Tags: epithelial cells, meibomian gland, neurotransmitters, forskolin, 1-methyl-3-isobutylxanthine
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8543-8548. doi:https://doi.org/10.1167/iovs.11-8113
Role of the IL-6 Classic- and Trans-Signaling Pathways in Corneal Sterile Inflammation and Wound Healing Free
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Nobuyuki Ebihara; Akira Matsuda; Shinji Nakamura; Hironori Matsuda; Akira Murakami
Tags: cornea, corneal epithelial cells, fibroblasts, inflammation, interleukin-6
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8549-8557. doi:https://doi.org/10.1167/iovs.11-7956
Oxidative Stress in Keratoconus? Free
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Emma Arnal; Cristina Peris-Martínez; Jose Luis Menezo; Siv Johnsen-Soriano; Francisco Javier Romero
Tags: antioxidants, cornea, keratoconus, oxidative stress, lipid peroxidation
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8592-8597. doi:https://doi.org/10.1167/iovs.11-7732
Increased Proliferation and Replicative Lifespan of Isolated Human Corneal Endothelial Cells with l-Ascorbic acid 2-phosphate Free
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Nobuyuki Shima; Miwa Kimoto; Masahiro Yamaguchi; Satoru Yamagami
Tags: ambulatory surgery center, cornea, endothelial cells, life span, phosphates
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8711-8717. doi:https://doi.org/10.1167/iovs.11-7592
Corneal Penetration of Topical and Subconjunctival Bevacizumab Free
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Mohammad H. Dastjerdi; Zahra Sadrai; Daniel R. Saban; Qiang Zhang; Reza Dana
Tags: bevacizumab, cornea
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8718-8723. doi:https://doi.org/10.1167/iovs.11-7871
Effect of Controlled Adverse Chamber Environment Exposure on Tear Functions in Silicon Hydrogel and Hydrogel Soft Contact Lens Wearers Free
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Takashi Kojima; Yukihiro Matsumoto; Osama M. A. Ibrahim; Tais Hitomi Wakamatsu; Miki Uchino; Kazumi Fukagawa; Junko Ogawa; Murat Dogru; Kazuno Negishi; Kazuo Tsubota
Tags: contact lenses, hydrophilic, evaporation, hydrogel, osmolar concentration, silicon
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8811-8817. doi:https://doi.org/10.1167/iovs.10-6841
Nonlinear Optical Macroscopic Assessment of 3-D Corneal Collagen Organization and Axial Biomechanics Free
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Moritz Winkler; Dongyul Chai; Shelsea Kriling; Chyong Jy Nien; Donald J. Brown; Bryan Jester; Tibor Juhasz; James V. Jester
Tags: collagen, cornea, biomechanics, optics, surgical flaps
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8818-8827. doi:https://doi.org/10.1167/iovs.11-8070
Reproducibility of Cornea Measurements in Anterior Segment OCT Images of Normal Eyes and Eyes with Bullous Keratopathy Analyzed with the Zhongshan Assessment Program Free
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Joy B. Chan; Leonard H. Yuen; Elaine H. Huang; Hla M. Htoon; Mingguang He; Tin Aung; Donald T. Tan; Jodhbir S. Mehta
Tags: bullous keratopathy, cornea, eye, software
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8884-8890. doi:https://doi.org/10.1167/iovs.10-6411
Vision-Related Quality of Life in Patients with Ocular Chemical Burns Free
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Qihua Le; Yan Chen; Xin Wang; Yimin Li; Jiaxu Hong; Jianjiang Xu
Tags: chemical eye burns, quality of life, vision, wounds and injuries, eye
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8951-8956. doi:https://doi.org/10.1167/iovs.11-8355
FGF-2– and TGF-β1–Induced Downregulation of Lumican and Keratocan in Activated Corneal Keratocytes by JNK Signaling Pathway Free
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Jian Chen; Julie Wong-Chong; Nirmala SundarRaj
Tags: cornea, down-regulation, fibroblast growth factor 2, keratocytes, signal pathway
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8957-8964. doi:https://doi.org/10.1167/iovs.11-8078
Equivalence of Biomechanical Changes Induced by Rapid and Standard Corneal Cross-linking, Using Riboflavin and Ultraviolet Radiation Free
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Silvia Schumacher; Lydia Oeftiger; Michael Mrochen
Tags: corneal collagen cross-linking, riboflavin, ultraviolet rays, cornea, cross-linking
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9048-9052. doi:https://doi.org/10.1167/iovs.11-7818
Doxycycline Enhances the Inhibitory Effects of Bevacizumab on Corneal Neovascularization and Prevents Its Side Effects Free
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Wenru Su; Zhanrong Li; Yongping Li; Miaoli Lin; Lin Yao; Yi Liu; Zixin He; Chuanbin Wu; Dan Liang
Tags: adverse effects, bevacizumab, burns, choroidal neovascularization, cornea
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9108-9115. doi:https://doi.org/10.1167/iovs.11-7255
Patient-Specific Computational Modeling of Keratoconus Progression and Differential Responses to Collagen Cross-linking Free
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Abhijit Sinha Roy; William J. Dupps, Jr
Tags: cornea, corneal collagen cross-linking, retinal cone, keratoconus, eye
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9174-9187. doi:https://doi.org/10.1167/iovs.11-7395
A Novel Mechanism of Increased Infections in Contact Lens Wearers Free
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Gabriel M. Gordon; Navid Moradshahi; Shinwu Jeong; Christianne Lane; M. Elizabeth Fini
Tags: contact lenses, infections, rose bengal, contact lens solutions
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9188-9194. doi:https://doi.org/10.1167/iovs.11-7658
Endothelial Cell Decay after Descemet's Stripping Automated Endothelial Keratoplasty and Top Hat Penetrating Keratoplasty Free
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Bart T. H. Van Dooren; Isabelle E. Y. Saelens; Isabel Bleyen; Paul G. H. Mulder; Marjolijn C. Bartels; Gabriel Van Rij
Tags: descemet stripping endothelial keratoplasty, endothelial cells, endothelium, keratoplasty, keratoplasty, penetrating
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9226-9231. doi:https://doi.org/10.1167/iovs.11-8107
Cross-Linking with Ultraviolet-A and Riboflavin Reduces Corneal Permeability Free
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Jay M. Stewart; On-Tat Lee; Fergus F. Wong; David S. Schultz; Ricardo Lamy
Tags: cornea, corneal collagen cross-linking, cross-linking, permeability, riboflavin
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9275-9278. doi:https://doi.org/10.1167/iovs.11-8155

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology

Quantifying Nystagmus in Infants and Young Children: Relation between Foveation and Visual Acuity Deficit Free
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Joost Felius; Valeria L. N. Fu; Eileen E. Birch; Richard W. Hertle; Reed M. Jost; Vidhya Subramanian
Tags: child, eye movement, infant, pathologic nystagmus, visual acuity
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8724-8731. doi:https://doi.org/10.1167/iovs.11-7760

Genetics

Complement Factor D in Age-Related Macular Degeneration Free
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Chloe M. Stanton; John R.W. Yates; Anneke I. den Hollander; Johanna M. Seddon; Anand Swaroop; Dwight Stambolian; Sascha Fauser; Carel Hoyng; Yi Yu; Kanda Atsuhiro; Kari Branham; Mohammad Othman; Wei Chen; Elod Kortvely; Kevin Chalmers; Caroline Hayward; Anthony T. Moore; Baljean Dhillon; Marius Ueffing; Alan F. Wright
Tags: age-related macular degeneration, complement factor d, copy number polymorphism, genes, genetics
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8828-8834. doi:https://doi.org/10.1167/iovs.11-7933
High-Throughput Retina-Array for Screening 93 Genes Involved in Inherited Retinal Dystrophy Free
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Jin Song; Nizar Smaoui; Radha Ayyagari; David Stiles; Sonia Benhamed; Ian M. MacDonald; Stephen P. Daiger; Santa J. Tumminia; Fielding Hejtmancik; Xinjing Wang
Tags: genes, hereditary retinal dystrophy, polymerase chain reaction, retina, screening
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9053-9060. doi:https://doi.org/10.1167/iovs.11-7978

Glaucoma

Anterior Chamber Angle Imaging with Swept-Source Optical Coherence Tomography: An Investigation on Variability of Angle Measurement Free
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Shu Liu; Marco Yu; Cong Ye; Dennis S. C. Lam; Christopher Kai-shun Leung
Tags: anterior chamber of eye, diagnostic imaging, optical coherence tomography, transient ischemic attack, sclera
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8598-8603. doi:https://doi.org/10.1167/iovs.11-7507
Gene Expression Changes in Steroid-Induced IOP Elevation in Bovine Trabecular Meshwork Free
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John Danias; Rosana Gerometta; Yongchao Ge; Lizhen Ren; Lampros Panagis; Thomas W. Mittag; Oscar A. Candia; Steven M. Podos
Tags: cattle, gene expression, intraocular pressure, steroids, genes
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8636-8645. doi:https://doi.org/10.1167/iovs.11-7563
Relationships between Visual Field Sensitivity and Spectral Absorption Properties of the Neuroretinal Rim in Glaucoma by Multispectral Imaging Free
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Jonathan Denniss; Ingo Schiessl; Vincent Nourrit; Cecilia H. Fenerty; Ramesh Gautam; David B. Henson
Tags: diagnostic imaging, glaucoma, neuroretinal rim, process of absorption, visual fields
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8732-8738. doi:https://doi.org/10.1167/iovs.11-8302
Longitudinal and Simultaneous Imaging of Retinal Ganglion Cells and Inner Retinal Layers in a Mouse Model of Glaucoma Induced by N-Methyl-d-Aspartate Free
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Noriko Nakano; Hanako Ohashi Ikeda; Masanori Hangai; Yuki Muraoka; Yoshinobu Toda; Akira Kakizuka; Nagahisa Yoshimura
Tags: aspartate, diagnostic imaging, eye, glaucoma, mice
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8754-8762. doi:https://doi.org/10.1167/iovs.10-6654
Autoreactive Antibodies and Loss of Retinal Ganglion Cells in Rats Induced by Immunization with Ocular Antigens Free
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Panagiotis Laspas; Oliver W. Gramlich; Harald D. Müller; Clemens S. Cuny; Philip F. Gottschling; Norbert Pfeiffer; H. Burkhard Dick; Stephanie C. Joachim; Franz H. Grus
Tags: antibodies, antigens, immunization, optic nerve, body tissue
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8835-8848. doi:https://doi.org/10.1167/iovs.10-6889
Histopathology of the Trabecular Meshwork and Schlemm's Canal in Primary Angle-Closure Glaucoma Free
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Teruhiko Hamanaka; Katsuaki Kasahara; Tamiko Takemura
Tags: angle closure glaucoma, epilepsy, temporal lobe, eye, histopathology tests, lupus erythematosus tumidus
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8849-8861. doi:https://doi.org/10.1167/iovs.11-7591
Measurement of Ocular Fundus Pulsation in Healthy Subjects Using a Novel Fourier-Domain Optical Coherence Tomography Free
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Kanwarpal Singh; Carolyne Dion; Marcelo Wajszilber; Tsuneyuki Ozaki; Mark R. Lesk; Santiago Costantino
Tags: cornea, optical coherence tomography, retina, eye, voluntary workers
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8927-8932. doi:https://doi.org/10.1167/iovs.11-7854
IOP-Induced Lamina Cribrosa Deformation and Scleral Canal Expansion: Independent or Related? Free
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Ian A. Sigal; Hongli Yang; Michael D. Roberts; Jonathan L. Grimm; Claude F. Burgoyne; Shaban Demirel; J. Crawford Downs
Tags: cribriform plate, intraocular pressure, sclera, eye
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9023-9032. doi:https://doi.org/10.1167/iovs.11-8183
Egr1 Expression Is Induced Following Glatiramer Acetate Immunotherapy in Rodent Models of Glaucoma and Alzheimer's Disease Free
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Sharon Bakalash; Michael Pham; Yosef Koronyo; Brenda C. Salumbides; Andrei Kramerov; Hillary Seidenberg; Dror Berel; Keith L. Black; Maya Koronyo-Hamaoui
Tags: alzheimer's disease, egr1 gene, genes, glatiramer acetate, glaucoma
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9033-9046. doi:https://doi.org/10.1167/iovs.11-7498

Immunology and Microbiology

Substance P in the Corneal Stroma Regulates the Severity of Herpetic Stromal Keratitis Lesions Free
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Brandon S Twardy; Rudragouda Channappanavar; Susmit Suvas
Tags: cornea, human herpesvirus 1, substance p, corneal stroma, stromal keratitis
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8604-8613. doi:https://doi.org/10.1167/iovs.11-8089
Following EAU Recovery There Is an Associated MC5r-Dependent APC Induction of Regulatory Immunity in the Spleen Free
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Darren J. Lee; Andrew W. Taylor
Tags: atrial premature complexes, immunity, mice, recovery of function, spleen
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8862-8867. doi:https://doi.org/10.1167/iovs.11-8153
Multiplex Sequencing of Seven Ocular Herpes Simplex Virus Type-1 Genomes: Phylogeny, Sequence Variability, and SNP Distribution Free
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Aaron W. Kolb; Marie Adams; Eric L. Cabot; Mark Craven; Curtis R. Brandt
Tags: genome, proteins, single nucleotide polymorphism, human herpesvirus 1, eye infection herpes simplex
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9061-9073. doi:https://doi.org/10.1167/iovs.11-7812
Active Immunization with Pneumolysin versus 23-Valent Polysaccharide Vaccine for Streptococcus pneumoniae Keratitis Free
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Erin W. Norcross; Melissa E. Sanders; Quincy C. Moore, III; Sidney D. Taylor; Nathan A. Tullos; Rhonda R. Caston; Sherrina N. Dixon; Moon H. Nahm; Robert L. Burton; Hilary Thompson; Larry S. McDaniel; Mary E. Marquart
Tags: cornea, immunization, immunization, active, infections, keratitis
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9232-9243. doi:https://doi.org/10.1167/iovs.10-6968

Low Vision

Barriers to Low Vision Rehabilitation: The Montreal Barriers Study Free
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Olga Overbury; Walter Wittich
Tags: blind rehabilitation therapy, montreal, rehabilitation, visual impairment, patient referral
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8933-8938. doi:https://doi.org/10.1167/iovs.11-8116

Multidisciplinary Ophthalmic Imaging

Suboptimal Image Focus Broadens Retinal Vessel Caliber Measurement Free
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Charles S. Chandler; Sapna Gangaputra; Larry D. Hubbard; Nicola J. Ferrier; Thomas W. Pauli; Qian Peng; Dennis W. Thayer; Ronald P. Danis, Jr
Tags: retinal vascular caliber, diameter, blurry vision
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8558-8561. doi:https://doi.org/10.1167/iovs.11-7917
Ocular Surface Epithelial Thickness Evaluation with Spectral-Domain Optical Coherence Tomography Free
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Marlène Francoz; Issouf Karamoko; Christophe Baudouin; Antoine Labbé
Tags: complement membrane attack complex, conjunctiva, epithelium, mac protocol, mdc protocol
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9116-9123. doi:https://doi.org/10.1167/iovs.11-7988

Physiology and Pharmacology

Human Retinal Pigment Epithelium Cells as Functional Models for the RPE In Vivo Free
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Zsolt Ablonczy; Mohammad Dahrouj; Peter H. Tang; Yueying Liu; Kumar Sambamurti; Alan D. Marmorstein; Craig E. Crosson
Tags: bodily secretions, retinal pigment epithelium, retinoids, vascular endothelial growth factor a, retinal pigment cell
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8614-8620. doi:https://doi.org/10.1167/iovs.11-8021
Ocular Responses and Visual Performance after Emergent Acceleration Stress Free
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Ming-Ling Tsai; Chi-Ting Horng; Chun-Cheng Liu; Pochuen Shieh; Chun-Ling Hung; Da-Wen Lu; Shang-Yi Chiang; Yi-Cheng Wu; Wen-Yaw Chiou
Tags: stress
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8680-8685. doi:https://doi.org/10.1167/iovs.11-7589
In Vivo Gene Expression Profiling of Retina Postintravitreal Injections of Dexamethasone and Triamcinolone at Clinically Relevant Time Points for Patient Care Free
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Zeljka Smit-McBride; Sara P. Modjtahedi; Christopher T. Cessna; David G. Telander; Leonard M. Hjelmeland; Lawrence S. Morse
Tags: genes, retina, signal transduction, dexamethasone, steroids
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8965-8978. doi:https://doi.org/10.1167/iovs.10-7084

Retina

Retinas of the Diurnal Rodent Arvicanthis ansorgei Are Highly Resistant to Experimentally Induced Stress and Degeneration Free
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Domitille L. Boudard; Niyazi Acar; Lionel Bretillon; David Hicks
Tags: retina, rodentia, tissue degeneration, stress
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8686-8700. doi:https://doi.org/10.1167/iovs.11-8162
Diabetic Retinopathy and Damage to Mitochondrial Structure and Transport Machinery Free
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Qing Zhong; Renu A. Kowluru
Tags: biological transport, diabetes mellitus, diabetic retinopathy, mitochondria, proteins
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8739-8746. doi:https://doi.org/10.1167/iovs.11-8045
Morphologic Choroidal and Scleral Changes at the Macula in Tilted Disc Syndrome with Staphyloma Using Optical Coherence Tomography Free
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Ichiro Maruko; Tomohiro Iida; Yukinori Sugano; Hiroshi Oyamada; Tetsuju Sekiryu
Tags: macula densa, macula lutea, optical coherence tomography, sclera, staphyloma
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8763-8768. doi:https://doi.org/10.1167/iovs.11-8195
Effects of Age, Sex, and Axial Length on the Three-Dimensional Profile of Normal Macular Layer Structures Free
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Sotaro Ooto; Masanori Hangai; Atsuo Tomidokoro; Hitomi Saito; Makoto Araie; Tomohiro Otani; Shoji Kishi; Kenji Matsushita; Naoyuki Maeda; Motohiro Shirakashi; Haruki Abe; Shinji Ohkubo; Kazuhisa Sugiyama; Aiko Iwase; Nagahisa Yoshimura
Tags: eye, fovea centralis, macula densa, macula lutea, retinal nerve fiber layer
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8769-8779. doi:https://doi.org/10.1167/iovs.11-8388
Association of Elastin Gene Polymorphism to Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy Free
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Kenji Yamashiro; Keisuke Mori; Isao Nakata; Takashi Tsuchihashi; Kuniko Horie-Inoue; Hideo Nakanishi; Akitaka Tsujikawa; Masaaki Saito; Tomohiro Iida; Ryo Yamada; Fumihiko Matsuda; Satoshi Inoue; Takuya Awata; Shin Yoneya; Nagahisa Yoshimura
Tags: age-related macular degeneration, eln gene, polymorphism, vascular diseases, single nucleotide polymorphism
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8780-8784. doi:https://doi.org/10.1167/iovs.11-8205
Age-Related Retinal Function Changes in Albino and Pigmented Rats Free
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Jason Charng; Christine T. O. Nguyen; Bang V. Bui; Algis J. Vingrys
Tags: aging, albinism, electroretinography, photoreceptors, rats
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8891-8899. doi:https://doi.org/10.1167/iovs.11-7602
Logarithmic Transformation of Spectral-Domain Optical Coherence Tomography Data in Uveitis-Associated Macular Edema Free
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John F. Payne; Beau B. Bruce; Lyndon B. K. Lee; Steven Yeh
Tags: edema, optical coherence tomography, uveitis, visual acuity
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8939-8943. doi:https://doi.org/10.1167/iovs.11-8193
Vasoinhibin Gene Transfer by Adenoassociated Virus Type 2 Protects against VEGF- and Diabetes-Induced Retinal Vasopermeability Free
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Mayda Ramírez; Zhijian Wu; Bibiana Moreno-Carranza; Michael C. Jeziorski; Edith Arnold; Nundehui Díaz-Lezama; Gonzalo Martínez de la Escalera; Peter Colosi; Carmen Clapp
Tags: diabetes mellitus, gene transfer techniques, spatial vectors, vascular endothelial growth factor a, viruses
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8944-8950. doi:https://doi.org/10.1167/iovs.11-8190
Persistent Inhibition of Oxygen-Induced Retinal Neovascularization by Anthrax Lethal Toxin Free
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Jennifer L. Bromberg-White; Elissa Boguslawski; Daniel Hekman; Eric Kort; Nicholas S. Duesbery
Tags: anthrax disease, cytokine, mice, mitogen-activated protein kinases, oxygen
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8979-8992. doi:https://doi.org/10.1167/iovs.11-7651
Lamellar Macular Hole: A Clinicopathologic Correlation of Surgically Excised Epiretinal Membranes Free
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Barbara Parolini; Ricarda G. Schumann; Matteo G. Cereda; Christos Haritoglou; Grazia Pertile
Tags: epiretinal membrane, macular holes, surgical procedures, operative, tissue membrane, collagen
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9074-9083. doi:https://doi.org/10.1167/iovs.11-8227
Microglia-Mediated IGF-I Neuroprotection in the rd10 Mouse Model of Retinitis Pigmentosa Free
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Ana I. Arroba; Noemí Álvarez-Lindo; Nico van Rooijen; Enrique J. de la Rosa
Tags: insulin-like growth factor i, mice, microglia, neuroprotection, retinitis pigmentosa
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9124-9130. doi:https://doi.org/10.1167/iovs.11-7736
Automated Discovery and Quantification of Image-Based Complex Phenotypes: A Twin Study of Drusen Phenotypes in Age-Related Macular Degeneration Free
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Gwenole Quellec; Stephen R. Russell; Johanna M. Seddon; Robyn Reynolds; Todd Scheetz; Vinit B. Mahajan; Edwin M. Stone; Michael D. Abràmoff
Tags: drusen, phenotype, twins, age-related macular degeneration, twin studies
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9195-9206. doi:https://doi.org/10.1167/iovs.10-6793
Disease Course of Patients with Unilateral Pigmentary Retinopathy Free
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Emorfily Potsidis; Eliot L. Berson; Michael A. Sandberg
Tags: disease progression, eye, retinitis pigmentosa, electroretinography, visual fields
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9244-9249. doi:https://doi.org/10.1167/iovs.11-7892
X-Linked Retinoschisis: RS1 Mutation Severity and Age Affect the ERG Phenotype in a Cohort of 68 Affected Male Subjects Free
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Kristen Bowles; Catherine Cukras; Amy Turriff; Yuri Sergeev; Susan Vitale; Ronald A. Bush; Paul A. Sieving
Tags: cohort studies, electroretinography, mutation, phenotype, x-linked retinoschisis
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9250-9256. doi:https://doi.org/10.1167/iovs.11-8115
Disruption of the Retinal Parafoveal Capillary Network in Type 2 Diabetes before the Onset of Diabetic Retinopathy Free
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Johnny Tam; Kavita P. Dhamdhere; Pavan Tiruveedhula; Silvestre Manzanera; Shirin Barez; Marcus A. Bearse, Jr; Anthony J. Adams; Austin Roorda
Tags: blood capillaries, diabetes mellitus, type 2, diabetic retinopathy, parafoveal region
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9257-9266. doi:https://doi.org/10.1167/iovs.11-8481
Central Retinal Function as Measured by the Multifocal Electroretinogram and Flicker Perimetry in Early Age-Related Macular Degeneration Free
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Thomas J. Gin; Chi D. Luu; Robyn H. Guymer
Tags: age-related macular degeneration, electroretinography, perimetry, photopsia, eye
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9267-9274. doi:https://doi.org/10.1167/iovs.11-8517

Retinal Cell Biology

Hypoxia-Regulated Retinal Glial Cell–Specific Promoter for Potential Gene Therapy in Disease Free
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Howard M. Prentice; Manas R Biswal; C. Kathleen Dorey; Janet C. Blanks
Tags: glial fibrillary acidic protein, hypoxia, gene therapy, neuroglia
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8562-8570. doi:https://doi.org/10.1167/iovs.10-6835
Expression and Functional Roles of Caspase-5 in Inflammatory Responses of Human Retinal Pigment Epithelial Cells Free
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Zong-Mei Bian; Susan G. Elner; Hemant Khanna; Carlos A. Murga-Zamalloa; Suresh Patil; Victor M. Elner
Tags: caspases, caspase-1
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8646-8656. doi:https://doi.org/10.1167/iovs.11-7570
High Glucose Induces Mitochondrial Morphology and Metabolic Changes in Retinal Pericytes Free
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Kyle Trudeau; Anthony J. A. Molina; Sayon Roy
Tags: glucose, language morphology, metabolic disturbance, mitochondria, morphology
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8657-8664. doi:https://doi.org/10.1167/iovs.11-7934
Role of Connective Tissue Growth Factor in the Retinal Vasculature during Development and Ischemia Free
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Liya Pi; Huiming Xia; Jianwen Liu; Anitha K. Shenoy; William W. Hauswirth; Edward W. Scott
Tags: connective tissue growth factor, ischemia, proteins, retinal vasculature
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8701-8710. doi:https://doi.org/10.1167/iovs.11-7870
Induction of Retinal Pigment Epithelial Cells from Monkey iPS Cells Free
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Satoshi Okamoto; Masayo Takahashi
Tags: cercopithecidae, retinal pigment cell
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8785-8790. doi:https://doi.org/10.1167/iovs.11-8129
Role of Mitochondria Biogenesis in the Metabolic Memory Associated with the Continued Progression of Diabetic Retinopathy and Its Regulation by Lipoic Acid Free
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Julia M. Santos; Renu A. Kowluru
Tags: diabetic retinopathy, mitochondria, origin of life, thioctic acid, memory
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8791-8798. doi:https://doi.org/10.1167/iovs.11-8203
Ectopic Proliferation Contributes to Retinal Dysplasia in the Juvenile Zebrafish patched2 Mutant Eye Free
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Jonathan Bibliowicz; Jeffrey M. Gross
Tags: child, retina, retinal dysplasia, zebrafish, eye
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8868-8877. doi:https://doi.org/10.1167/iovs.11-8033
The Sand Rat, Psammomys obesus, Develops Type 2 Diabetic Retinopathy Similar to Humans Free
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Tounès Saïdi; Sihem Mbarek; Samy Omri; Francine Behar-Cohen; Rafika Ben Chaouacha-Chekir; David Hicks
Tags: diabetes mellitus, diabetic retinopathy, proteins, retina, silicon dioxide
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8993-9004. doi:https://doi.org/10.1167/iovs.11-8423
Retinal Pericytes Inhibit Activated T Cell Proliferation Free
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Zhidan Tu; Yan Li; Dawn S. Smith; Nader Sheibani; Suber Huang; Timothy Kern; Feng Lin
Tags: pericytes, t-lymphocytes
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9005-9010. doi:https://doi.org/10.1167/iovs.11-8008
A Novel Bisretinoid of Retina Is an Adduct on Glycerophosphoethanolamine Free
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Kazunori Yamamoto; Kee Dong Yoon; Keiko Ueda; Masaru Hashimoto; Janet R. Sparrow
Tags: energy absorbance, eye, mice, oxidation, retina
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9084-9090. doi:https://doi.org/10.1167/iovs.11-8632
Insight into the Role of Ca2+-Binding Protein 5 in Vesicle Exocytosis Free
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Izabela Sokal; Françoise Haeseleer
Tags: myosins, proteins, retina, pc12 cells, exocytosis
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9131-9141. doi:https://doi.org/10.1167/iovs.11-8246
Roles of AMP-Activated Protein Kinase in Diabetes-Induced Retinal Inflammation Free
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Shunsuke Kubota; Yoko Ozawa; Toshihide Kurihara; Mariko Sasaki; Kenya Yuki; Seiji Miyake; Kousuke Noda; Susumu Ishida; Kazuo Tsubota
Tags: aica ribonucleotide, diabetes mellitus, diabetes mellitus, type 2, resveratrol, inflammation
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9142-9148. doi:https://doi.org/10.1167/iovs.11-8041
Polarized Distribution of Heme Transporters in Retinal Pigment Epithelium and Their Regulation in the Iron-Overload Disease Hemochromatosis Free
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Jaya P. Gnana-Prakasam; Sushma K. Reddy; Rajalakshmi Veeranan-Karmegam; Sylvia B. Smith; Pamela M. Martin; Vadivel Ganapathy
Tags: heme, hemochromatosis, iron overload, membrane transport proteins, mice
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9279-9286. doi:https://doi.org/10.1167/iovs.11-8264

Visual Neuroscience

Retinal Pathway Origins of the Pattern Electroretinogram (PERG) Free
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Xunda Luo; Laura J. Frishman
Tags: electroretinography, erg protein, human, glaucoma, macaca
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8571-8584. doi:https://doi.org/10.1167/iovs.11-8376
Visual Cortical Function in Very Low Birth Weight Infants without Retinal or Cerebral Pathology Free
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Chuan Hou; Anthony M. Norcia; Ashima Madan; Solina Tith; Rashi Agarwal; William V. Good
Tags: brain, infant, infant, premature, infant, very low birth weight, pathology
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9091-9098. doi:https://doi.org/10.1167/iovs.11-7458

Visual Psychophysics and Physiological Optics

Functional Loss in the Magnocellular and Parvocellular Pathways in Patients with Optic Neuritis Free
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Dingcai Cao; Andrew J. Zele; Joel Pokorny; David Y. Lee; Leonard V. Messner; Christopher Diehl; Susan Ksiazek
Tags: optic neuritis
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8900-8907. doi:https://doi.org/10.1167/iovs.11-7644
The Perceptual Consequences of Interocular Suppression in Amblyopia Free
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Goro Maehara; Benjamin Thompson; Behzad Mansouri; Reza Farivar; Robert F. Hess
Tags: amblyopia, eye, luminance, perception
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9011-9017. doi:https://doi.org/10.1167/iovs.11-7748

Clinical Trials

Miniaturized High-Intensity Focused Ultrasound Device in Patients with Glaucoma: A Clinical Pilot Study Free
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Florent Aptel; Thomas Charrel; Cyril Lafon; Fabrice Romano; Jean-Yves Chapelon; Esther Blumen-Ohana; Jean-Philippe Nordmann; Philippe Denis
Tags: glaucoma, high-intensity focused ultrasound, intraocular pressure, pilot projects, ultrasound biomicroscopy
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8747-8753. doi:https://doi.org/10.1167/iovs.11-8137
Central Areolar Choroidal Dystrophy (CACD) and Age-Related Macular Degeneration (AMD): Differentiating Characteristics in Multimodal Imaging Free
PDF
Dženita Smailhodzic; Monika Fleckenstein; Thomas Theelen; Camiel J. F. Boon; Ramon A. C. van Huet; Johannes P. H. van de Ven; Anneke I. Den Hollander; Steffen Schmitz-Valckenberg; Carel B. Hoyng; Bernhard H. F. Weber; Frank G. Holz; B. Jeroen Klevering
Tags: age-related macular degeneration, atrophy, diagnostic imaging, eye, atrophic condition of skin
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8908-8918. doi:https://doi.org/10.1167/iovs.11-7926
Supplementation with All Three Macular Carotenoids: Response, Stability, and Safety Free
PDF
Eithne E. Connolly; Stephen Beatty; James Loughman; Alan N. Howard; Michael S. Louw; John M. Nolan
Tags: carotenoids, safety, lutein, pathology, clinical
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9207-9217. doi:https://doi.org/10.1167/iovs.11-8025
New Grading Criteria Allow for Earlier Detection of Geographic Atrophy in Clinical Trials Free
PDF
Hilary Smolen Brader; Gui-shuang Ying; E. Revell Martin; Maureen G. Maguire; the Complications of Age-Related Macular Degeneration Prevention Trial (CAPT) Research Group
Tags: atrophy, diagnostic imaging, color, reliability
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9218-9225. doi:https://doi.org/10.1167/iovs.11-7493

Perspective

Beyond AREDS: Is There a Place for Antioxidant Therapy in the Prevention/Treatment of Eye Disease? Free
PDF
Renu A. Kowluru; Qing Zhong
Tags: antioxidants, diabetic retinopathy, eye diseases, prevention, diabetes mellitus
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 8665-8671. doi:https://doi.org/10.1167/iovs.10-6768

Letters to the Editor

VEGF and PEDF Secretion in ARPE-19 and fhRPE Cells Free
PDF
Ram Kannan; Parameswaran G. Sreekumar; David R. Hinton
Tags: bodily secretions, vascular endothelial growth factor a
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9047. doi:https://doi.org/10.1167/iovs.11-8737
Predictors of Visual Acuity in Macular Edema Free
PDF
Jay Kumar Chhablani; William Freeman
Tags: edema, visual acuity
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9287. doi:https://doi.org/10.1167/iovs.11-8750
Will the BEAT-ROP Study Results Really Beat ROP? Free
PDF
Seemant Raizada; Jamal Al Kandari; Khalid Al Sabti
Tags: research outcome
Investigative Ophthalmology & Visual Science November 2011, Vol.52, 9288-9289. doi:https://doi.org/10.1167/iovs.11-8479
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